Slc4a1 (solute carrier family 4 (anion exchanger), member 1) - Rat Genome Database

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Gene: Slc4a1 (solute carrier family 4 (anion exchanger), member 1) Mus musculus
Analyze
Symbol: Slc4a1
Name: solute carrier family 4 (anion exchanger), member 1
RGD ID: 11309
MGI Page MGI
Description: Enables anion transmembrane transporter activity; ankyrin binding activity; and hemoglobin binding activity. Involved in chloride transport. Acts upstream of or within several processes, including bicarbonate transport; negative regulation of glycolytic process through fructose-6-phosphate; and pH elevation. Located in basolateral plasma membrane; cortical cytoskeleton; and cytoplasmic side of plasma membrane. Is expressed in several structures, including blood; cardiovascular system; liver; lung; and metanephros. Used to study hereditary spherocytosis type 4 and renal tubular acidosis. Human ortholog(s) of this gene implicated in congenital hemolytic anemia; hereditary spherocytosis; hereditary spherocytosis type 4; malaria; and renal tubular acidosis. Orthologous to human SLC4A1 (solute carrier family 4 member 1 (Diego blood group)).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Ae; AE 1; Ae1; anion exchange protein 1; anion exchanger 1; band 3 anion transport protein; CD233; Empb; Empb3; erythrocyte membrane protein band 3; l11Jus; l11Jus51; MEB3; solute carrier family 4 member 1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911102,239,646 - 102,256,107 (-)NCBIGRCm39mm39
GRCm39 Ensembl11102,239,650 - 102,257,029 (-)Ensembl
GRCm3811102,348,820 - 102,365,281 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11102,348,824 - 102,366,203 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711102,210,134 - 102,226,595 (-)NCBIGRCm37mm9NCBIm37
MGSCv3611102,164,917 - 102,181,205 (-)NCBImm8
Celera11114,058,195 - 114,074,658 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1166.29NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (EXP)
1-naphthyl isothiocyanate  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-butoxyethanol  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-diisothiocyano-trans-stilbene-2,2'-disulfonic acid  (ISO)
4,4'-dinitrostilbene-2,2'-disulfonic acid  (ISO)
4,4'-sulfonyldiphenol  (EXP)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
aconitine  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (ISO)
aristolochic acid  (ISO)
atorvastatin calcium  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
benzo[e]pyrene  (ISO)
Benzo[ghi]perylene  (EXP)
Benzo[k]fluoranthene  (EXP)
beta-naphthoflavone  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (ISO)
C60 fullerene  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (EXP)
CGP 52608  (ISO)
cholesterol  (ISO)
cisplatin  (EXP)
clofibrate  (EXP)
copper(II) sulfate  (ISO)
D-glucose  (ISO)
D-penicillamine  (ISO)
dexamethasone  (ISO)
dextran sulfate  (EXP)
dibenz[a,h]anthracene  (EXP)
dibutyl phthalate  (EXP)
dichloroacetic acid  (EXP)
diclofenac  (EXP)
dioxygen  (EXP,ISO)
dipyridamole  (ISO)
folic acid  (EXP)
furan  (ISO)
furans  (ISO)
gentamycin  (ISO)
glucose  (ISO)
hydrogen peroxide  (ISO)
lead diacetate  (ISO)
metformin  (ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
methoxychlor  (ISO)
methyl isocyanate  (ISO)
monosodium L-glutamate  (ISO)
N-acetyl-L-cysteine  (ISO)
N-ethyl-N-nitrosourea  (EXP)
Niflumic acid  (ISO)
nitrofen  (ISO)
oxaliplatin  (ISO)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenformin  (ISO)
phenobarbital  (EXP)
pirinixic acid  (ISO)
potassium atom  (ISO)
potassium dichromate  (EXP)
resveratrol  (ISO)
rotenone  (EXP,ISO)
selenous acid  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (EXP)
sodium arsenite  (ISO)
sodium atom  (ISO)
sodium hydrogencarbonate  (ISO)
sulfates  (EXP,ISO)
tebuconazole  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
titanium dioxide  (EXP)
topotecan  (ISO)
trichloroethene  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
triptonide  (EXP)
tungsten  (EXP)
valdecoxib  (ISO)
valproic acid  (ISO)
vancomycin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Modulation of clinical expression and band 3 deficiency in hereditary spherocytosis. Alloisio N, etal., Blood. 1997 Jul 1;90(1):414-20.
2. Cardiac hypertrophy in anion exchanger 1-null mutant mice with severe hemolytic anemia. Alvarez BV, etal., Am J Physiol Heart Circ Physiol. 2007 Mar;292(3):H1301-12. Epub 2006 Oct 20.
3. Pathogenic autoantibodies in the NZB mouse are specific for erythrocyte band 3 protein. Barker RN, etal., Eur J Immunol. 1993 Jul;23(7):1723-6.
4. Regulation of the basolateral chloride/base exchangers AE1 and SLC26A7 in the kidney collecting duct in potassium depletion. Barone S, etal., Nephrol Dial Transplant. 2007 Dec;22(12):3462-70. Epub 2007 Sep 5.
5. Monovalent cation leaks in human red cells caused by single amino-acid substitutions in the transport domain of the band 3 chloride-bicarbonate exchanger, AE1. Bruce LJ, etal., Nat Genet. 2005 Nov;37(11):1258-63. Epub 2005 Oct 9.
6. dRTA and hemolytic anemia: first detailed description of SLC4A1 A858D mutation in homozygous state. Fawaz NA, etal., Eur J Haematol. 2012 Apr;88(4):350-5. doi: 10.1111/j.1600-0609.2011.01739.x. Epub 2012 Jan 4.
7. Mature erythrocyte membrane homeostasis is compromised by loss of the GATA1-FOG1 interaction. Hasegawa A, etal., Blood. 2012 Mar 15;119(11):2615-23. doi: 10.1182/blood-2011-09-382473. Epub 2012 Jan 25.
8. Expression of rat kidney anion exchanger 1 in type A intercalated cells in metabolic acidosis and alkalosis. Huber S, etal., Am J Physiol. 1999 Dec;277(6 Pt 2):F841-9.
9. Duplication of 10 nucleotides in the erythroid band 3 (AE1) gene in a kindred with hereditary spherocytosis and band 3 protein deficiency (band 3PRAGUE). Jarolim P, etal., J Clin Invest. 1994 Jan;93(1):121-30.
10. Deletion in erythrocyte band 3 gene in malaria-resistant Southeast Asian ovalocytosis. Jarolim P, etal., Proc Natl Acad Sci U S A. 1991 Dec 15;88(24):11022-6.
11. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
12. Oxidation as a possible mechanism of cellular aging: vitamin E deficiency causes premature aging and IgG binding to erythrocytes. Kay MM, etal., Proc Natl Acad Sci U S A. 1986 Apr;83(8):2463-7.
13. Tropical distal renal tubular acidosis: clinical and epidemiological studies in 78 patients. Khositseth S, etal., QJM. 2012 Sep;105(9):861-77. doi: 10.1093/qjmed/hcs139.
14. Abnormalities of ion-exchange proteins of the red cell membrane in iron deficiency anemia. Li JY, etal., Chin Med J (Engl). 1992 Feb;105(2):116-9.
15. Band 3 Campinas: a novel splicing mutation in the band 3 gene (AE1) associated with hereditary spherocytosis, hyperactivity of Na+/Li+ countertransport and an abnormal renal bicarbonate handling. Lima PR, etal., Blood. 1997 Oct 1;90(7):2810-8.
16. Band 3 Chur: a variant associated with band 3-deficient hereditary spherocytosis and substitution in a highly conserved position of transmembrane segment 11. Maillet P, etal., Br J Haematol. 1995 Dec;91(4):804-10.
17. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
18. MGDs mouse GO annotations MGD data from the GO Consortium
19. MGD IEA MGD IEA
20. The calcineurin inhibitor FK506 (tacrolimus) is associated with transient metabolic acidosis and altered expression of renal acid-base transport proteins. Mohebbi N, etal., Am J Physiol Renal Physiol. 2009 Aug;297(2):F499-509. doi: 10.1152/ajprenal.90489.2008. Epub 2009 May 13.
21. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
22. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
23. Irreversible AE1 tyrosine phosphorylation leads to membrane vesiculation in G6PD deficient red cells. Pantaleo A, etal., PLoS One. 2011 Jan 5;6(1):e15847. doi: 10.1371/journal.pone.0015847.
24. Mouse MP Annotation Import Pipeline RGD automated import pipeline
25. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
26. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
27. Monoclonal antibodies recognizing epitopes on the extracellular face and intracellular N-terminus of the human erythrocyte anion transporter (band 3) and their application to the analysis of South East Asian ovalocytes. Smythe JS, etal., Blood. 1995 May 15;85(10):2929-36.
28. Targeted disruption of the murine erythroid band 3 gene results in spherocytosis and severe haemolytic anaemia despite a normal membrane skeleton. Southgate CD, etal., Nat Genet. 1996 Oct;14(2):227-30.
29. Distal renal tubular acidosis in mice lacking the AE1 (band3) Cl-/HCO3- exchanger (slc4a1). Stehberger PA, etal., J Am Soc Nephrol. 2007 May;18(5):1408-18. Epub 2007 Apr 4.
30. Natural antiband 3 antibodies in patients with sickle cell disease. Villaescusa R, etal., C R Biol. 2013 Mar;336(3):173-6. doi: 10.1016/j.crvi.2012.09.002. Epub 2012 Oct 12.
31. Promoter polymorphism of the anion-exchange protein 1 associated with severe malarial anemia and fatality. von Kalckreuth V, etal., J Infect Dis. 2006 Oct 1;194(7):949-57. Epub 2006 Aug 30.
Additional References at PubMed
PMID:1581325   PMID:1794058   PMID:2042971   PMID:2268683   PMID:2377456   PMID:2410791   PMID:2479548   PMID:2542243   PMID:2713407   PMID:3015590   PMID:3036795   PMID:3182834  
PMID:3478298   PMID:3478687   PMID:3840489   PMID:7522566   PMID:7592657   PMID:7812009   PMID:7894173   PMID:8081002   PMID:8449498   PMID:8704215   PMID:8798454   PMID:8808627  
PMID:8833256   PMID:8977242   PMID:9227323   PMID:9422766   PMID:9490702   PMID:9716609   PMID:10349636   PMID:10358158   PMID:10491632   PMID:10772878   PMID:10922068   PMID:11042159  
PMID:11076861   PMID:11498539   PMID:11591653   PMID:11831035   PMID:12388412   PMID:12477932   PMID:12669066   PMID:12832463   PMID:12933803   PMID:12955145   PMID:14612590   PMID:15007064  
PMID:15070709   PMID:15238261   PMID:15328023   PMID:15489334   PMID:16077082   PMID:16141072   PMID:16141073   PMID:16466971   PMID:16728274   PMID:17079272   PMID:17251326   PMID:17300687  
PMID:17382523   PMID:17690150   PMID:17696498   PMID:17715300   PMID:17785581   PMID:17855646   PMID:18094026   PMID:18329299   PMID:18480299   PMID:18524950   PMID:18554416   PMID:18663336  
PMID:18698006   PMID:18723693   PMID:18799693   PMID:19521566   PMID:19567882   PMID:19704006   PMID:19855135   PMID:20011118   PMID:20056793   PMID:20346715   PMID:20347762   PMID:20576809  
PMID:20696915   PMID:20833366   PMID:21267068   PMID:21455273   PMID:21649639   PMID:21677750   PMID:21873635   PMID:21873807   PMID:22147703   PMID:22226968   PMID:22452706   PMID:23383138  
PMID:23610411   PMID:23704941   PMID:23878365   PMID:24159174   PMID:25012180   PMID:25778531   PMID:25972512   PMID:27518902   PMID:27582101   PMID:27688804   PMID:27848995   PMID:27932475  
PMID:28378742   PMID:28701737   PMID:29237740   PMID:31536436   PMID:32023452   PMID:34354145  


Genomics

Comparative Map Data
Slc4a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911102,239,646 - 102,256,107 (-)NCBIGRCm39mm39
GRCm39 Ensembl11102,239,650 - 102,257,029 (-)Ensembl
GRCm3811102,348,820 - 102,365,281 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11102,348,824 - 102,366,203 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711102,210,134 - 102,226,595 (-)NCBIGRCm37mm9NCBIm37
MGSCv3611102,164,917 - 102,181,205 (-)NCBImm8
Celera11114,058,195 - 114,074,658 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1166.29NCBI
SLC4A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381744,248,390 - 44,268,135 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1744,248,390 - 44,268,141 (-)EnsemblGRCh38hg38GRCh38
GRCh371742,325,758 - 42,345,503 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361739,682,566 - 39,700,993 (-)NCBINCBI36hg18NCBI36
Build 341739,682,565 - 39,700,993NCBI
Celera1739,034,465 - 39,054,210 (-)NCBI
Cytogenetic Map17q21.31NCBI
HuRef1738,089,106 - 38,108,850 (-)NCBIHuRef
CHM1_11742,561,259 - 42,581,020 (-)NCBICHM1_1
T2T-CHM13v2.01745,101,499 - 45,121,240 (-)NCBI
Slc4a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21087,306,865 - 87,323,132 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1087,306,872 - 87,323,117 (-)Ensembl
Rnor_6.01090,296,144 - 90,312,401 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1090,296,141 - 90,312,386 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01090,084,734 - 90,101,181 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41091,454,824 - 91,471,072 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11091,470,679 - 91,479,502 (-)NCBI
Celera1086,018,849 - 86,032,669 (-)NCBICelera
Cytogenetic Map10q32.1NCBI
Slc4a1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545117,315,024 - 17,328,103 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545117,318,600 - 17,330,943 (-)NCBIChiLan1.0ChiLan1.0
SLC4A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11713,302,796 - 13,317,312 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1713,302,796 - 13,317,312 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01713,131,851 - 13,150,872 (+)NCBIMhudiblu_PPA_v0panPan3
SLC4A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1919,142,884 - 19,159,449 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl919,146,480 - 19,157,915 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha918,535,326 - 18,546,756 (+)NCBI
ROS_Cfam_1.0919,836,393 - 19,852,954 (+)NCBI
ROS_Cfam_1.0 Ensembl919,839,985 - 19,851,420 (+)Ensembl
UMICH_Zoey_3.1918,693,717 - 18,705,143 (+)NCBI
UNSW_CanFamBas_1.0918,877,006 - 18,888,427 (+)NCBI
UU_Cfam_GSD_1.0919,021,401 - 19,032,836 (+)NCBI
Slc4a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560218,460,919 - 18,477,383 (+)NCBI
SpeTri2.0NW_004936541718,577 - 727,420 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC4A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1218,957,807 - 18,974,208 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11218,957,813 - 18,975,266 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21219,180,392 - 19,196,592 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SLC4A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11662,126,370 - 62,146,192 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1662,131,709 - 62,146,182 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607732,895,386 - 32,915,473 (+)NCBIVero_WHO_p1.0
Slc4a1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624795743,646 - 752,103 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_004624795739,821 - 752,773 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
AW551993  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811102,348,971 - 102,349,055UniSTSGRCm38
MGSCv3711102,210,285 - 102,210,369UniSTSGRCm37
Celera11114,058,345 - 114,058,429UniSTS
Cytogenetic Map11DUniSTS
cM Map1162.0UniSTS
Whitehead/MRC_RH111376.8UniSTS
PMC162203P2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811102,350,200 - 102,351,162UniSTSGRCm38
MGSCv3711102,211,514 - 102,212,476UniSTSGRCm37
Celera11114,059,574 - 114,060,536UniSTS
Cytogenetic Map11DUniSTS
cM Map1162.0UniSTS
Slc4a1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811102,349,486 - 102,349,625UniSTSGRCm38
MGSCv3711102,210,800 - 102,210,939UniSTSGRCm37
Celera11114,058,860 - 114,058,999UniSTS
Cytogenetic Map11DUniSTS
cM Map1162.0UniSTS
Slc4a1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811102,355,471 - 102,355,592UniSTSGRCm38
MGSCv3711102,216,785 - 102,216,906UniSTSGRCm37
Celera11114,064,846 - 114,064,969UniSTS
Cytogenetic Map11DUniSTS
cM Map1162.0UniSTS
Slc4a1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11DUniSTS
cM Map1162.0UniSTS


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44630038113058009Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156864027114157957Mouse
27226730Tibmd1_mtibia midshaft diameter 1, 5 week (mouse)1162590826109390826Mouse
1558812Rafar_mretinoic acid induced forelimb autopod reduction (mouse)Not determined1170691198104691366Mouse
1301681Sle13_msystematic lupus erythematosus susceptibility 13 (mouse)Not determined1170691198104691366Mouse
1300651Pcyts3_mplasmacytoma susceptibility 3 (mouse)Not determined1170691198104691366Mouse
4141339Nilac2_mnicotine induced locomotor activity 2 (mouse)Not determined1170691198104691366Mouse
1301404Sbmd4_mspinal bone mineral density 4 (mouse)Not determined1172019649106019734Mouse
1301310Tmevd5_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 5 (mouse)Not determined1172726125106726289Mouse
4142348Pstc2_mperiosteal circumference 2 (mouse)Not determined1172818615106818733Mouse
10043866Adip19_madiposity 19 (mouse)Not determined1172818615106818733Mouse
11038695Par8_mpulmonary adenoma resistance 8 (mouse)1177063779111063918Mouse
1301414Heal10_mwound healing/regeneration 10 (mouse)Not determined1177437183111437322Mouse
10045616Heal25_mwound healing/regeneration 25 (mouse)Not determined1177437183111437322Mouse
10413882Moe1_mmodifier of epilepsy 1 (mouse)1177770978111771099Mouse
1301640Lore4_mloss of righting induced by ethanol 4 (mouse)Not determined1179156009107616472Mouse
14746970Manh71_mmandible shape 71 (mouse)1179416257113416257Mouse
10043865T2dm5sa_mtype 2 diabetes mellitus 5 in SMXA RI mice (mouse)Not determined1179813759104502698Mouse
1300649Crhq1_mcompensatory renal hypertrophy QTL 1 (mouse)Not determined1181574481115574636Mouse
1300766Skull16_mskull morphology 16 (mouse)Not determined1181574481115574636Mouse
10412288Carg4_mCandida albicans resistance gene 4 (mouse)Not determined1181810267115810267Mouse
1301072Eae22_mexperimental allergic encephalomyelitis 22 (mouse)Not determined1182377698116377820Mouse
14747003Mancz9_mmandible centroid size 9 (mouse)1185844911119844911Mouse
15039374Adip29_madiposity 29 (mouse)1186608320120608320Mouse
15039376Bw42_mbody weight QTL 42 (mouse)1186608320120608320Mouse
15014785Mvlq1_mmacrovesicular liver lesion QTL 1 (mouse)1186608320120608320Mouse
27226789Feml16_mfemur length 16, 10 week (mouse)1187490826121873369Mouse
10044007Hbnr14_mHeligmosomoides bakeri nematode resistance 14 (mouse)Not determined1187502600121502698Mouse
1357631Motr1_mmodifier of tubby retinal degeneration 1 (mouse)Not determined1187691198103274115Mouse
11251723Ewc5_methanol withdrawal and consumption 5 (mouse)1189869251121973369Mouse
1558753Ath19_matherosclerosis 19 (mouse)Not determined1191604608121973369Mouse
1302034Pkccl_mprotein kinase C content in lungs (mouse)Not determined1191604608121973369Mouse
10045617Heal26_mwound healing/regeneration 26 (mouse)Not determined1192939373112544554Mouse
1301095El6_mepilepsy 6 (mouse)Not determined1193229183121973369Mouse
4141939Pregq2_mpregnancy QTL 2 (mouse)Not determined1194063779118022724Mouse
27226731Tibmd4_mtibia midshaft diameter 4, 10 week (mouse)1194190826118890826Mouse
4141465Dbm2_mdiabetes modifier 2 (mouse)Not determined94437183118022724Mouse
1301958Alcp18_malcohol preference locus 18 (mouse)Not determined1195403965121973369Mouse
1300944Alcp20_malcohol preference locus 20 (mouse)Not determined1195403965121973369Mouse
1300962Cd8mts4_mCD8 memory T cell subset 4 (mouse)Not determined1196137674121973369Mouse
1301535Pas5b_mpulmonary adenoma susceptibility 5b (mouse)Not determined1196176465108806384Mouse
1301057Nidd4_mnon-insulin-dependent diabetes mellitus 4 (mouse)Not determined1196810136121973369Mouse
12910539Sstapa3_msuseptibility to Staphylococcus aureus infection 3 (mouse)1196897693110603991Mouse
1301983Berr2_mberghei resistance locus 2 (mouse)Not determined1198352609121973369Mouse
10043976Obq33_mobesity QTL 33 (mouse)Not determined1198500469121973369Mouse
10044001Alcw8_malcohol withdrawal 8 (mouse)Not determined1199254187121973369Mouse
11553867Stmm5_mskin tumor modifier of MSM 5 (mouse)11100058103121973369Mouse
11341721Rvfs2_mRift Valley fever susceptibility 2 (mouse)11100254186120887165Mouse
1301012Vispl_mvisual placing (mouse)Not determined11101022590121973369Mouse
14700693Ppiq12_mprepulse inhibition QTL 12 (mouse)11101504820114472363Mouse
14700694Ppiq13_mprepulse inhibition QTL 13 (mouse)11101504820114472363Mouse
14700695Ppiq14_mprepulse inhibition QTL 14 (mouse)11101504820114472363Mouse
14700696Ppiq15_mprepulse inhibition QTL 15 (mouse)11101504820114472363Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1209
Count of miRNA genes:596
Interacting mature miRNAs:716
Transcripts:ENSMUST00000006749, ENSMUST00000128405, ENSMUST00000145636, ENSMUST00000149993, ENSMUST00000151050
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_011403 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AH001857 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK010967 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK137542 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK157181 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK157833 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK157861 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK158143 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK158184 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK158243 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK158453 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK162616 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK165195 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK165267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK171662 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK171808 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK171845 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK172103 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK172316 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK172395 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK172456 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK172569 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL596258 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL954730 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY296129 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC052419 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC053429 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466558 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M29379 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  W75328 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X02677 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X03917 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000006749   ⟹   ENSMUSP00000006749
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11102,239,650 - 102,256,106 (-)Ensembl
GRCm38.p6 Ensembl11102,348,824 - 102,365,280 (-)Ensembl
RefSeq Acc Id: ENSMUST00000128405
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11102,251,021 - 102,256,073 (-)Ensembl
GRCm38.p6 Ensembl11102,360,195 - 102,365,247 (-)Ensembl
RefSeq Acc Id: ENSMUST00000145636
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11102,250,988 - 102,254,530 (-)Ensembl
GRCm38.p6 Ensembl11102,360,162 - 102,363,704 (-)Ensembl
RefSeq Acc Id: ENSMUST00000149993
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11102,249,908 - 102,251,394 (-)Ensembl
GRCm38.p6 Ensembl11102,359,082 - 102,360,568 (-)Ensembl
RefSeq Acc Id: ENSMUST00000151050
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11102,252,213 - 102,257,029 (-)Ensembl
GRCm38.p6 Ensembl11102,361,387 - 102,366,203 (-)Ensembl
RefSeq Acc Id: NM_011403   ⟹   NP_035533
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911102,239,646 - 102,256,107 (-)NCBI
GRCm3811102,348,820 - 102,365,281 (-)ENTREZGENE
MGSCv3711102,210,134 - 102,226,595 (-)RGD
Celera11114,058,195 - 114,074,658 (-)RGD
cM Map11 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_035533 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA37187 (Get FASTA)   NCBI Sequence Viewer  
  AAA37278 (Get FASTA)   NCBI Sequence Viewer  
  AAH52419 (Get FASTA)   NCBI Sequence Viewer  
  AAH53429 (Get FASTA)   NCBI Sequence Viewer  
  AAP51174 (Get FASTA)   NCBI Sequence Viewer  
  BAE23401 (Get FASTA)   NCBI Sequence Viewer  
  BAE33990 (Get FASTA)   NCBI Sequence Viewer  
  BAE34217 (Get FASTA)   NCBI Sequence Viewer  
  BAE34239 (Get FASTA)   NCBI Sequence Viewer  
  BAE34381 (Get FASTA)   NCBI Sequence Viewer  
  BAE34398 (Get FASTA)   NCBI Sequence Viewer  
  BAE34420 (Get FASTA)   NCBI Sequence Viewer  
  BAE34515 (Get FASTA)   NCBI Sequence Viewer  
  BAE36992 (Get FASTA)   NCBI Sequence Viewer  
  BAE38072 (Get FASTA)   NCBI Sequence Viewer  
  BAE38112 (Get FASTA)   NCBI Sequence Viewer  
  BAE42674 (Get FASTA)   NCBI Sequence Viewer  
  BAE42941 (Get FASTA)   NCBI Sequence Viewer  
  BAE42983 (Get FASTA)   NCBI Sequence Viewer  
  BAE43071 (Get FASTA)   NCBI Sequence Viewer  
  CAA26506 (Get FASTA)   NCBI Sequence Viewer  
  CAA27555 (Get FASTA)   NCBI Sequence Viewer  
  EDL34114 (Get FASTA)   NCBI Sequence Viewer  
  EDL34115 (Get FASTA)   NCBI Sequence Viewer  
  EDL34116 (Get FASTA)   NCBI Sequence Viewer  
  EDL34117 (Get FASTA)   NCBI Sequence Viewer  
  P04919 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_035533   ⟸   NM_011403
- UniProtKB: P04919 (UniProtKB/Swiss-Prot),   Q3TZ29 (UniProtKB/TrEMBL),   Q53ZN9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000006749   ⟸   ENSMUST00000006749
Protein Domains
Band_3_cyto   HCO3_cotransp

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P04919-F1-model_v2 AlphaFold P04919 1-929 view protein structure

Promoters
RGD ID:6822147
Promoter ID:MM_KWN:9974
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Spleen
Transcripts:OTTMUST00000014255
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3611102,222,596 - 102,223,096 (-)MPROMDB
RGD ID:6822148
Promoter ID:MM_KWN:9975
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Spleen
Transcripts:OTTMUST00000005592
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3611102,224,796 - 102,225,297 (-)MPROMDB
RGD ID:6849684
Promoter ID:EP25043
Type:initiation region
Name:MM_B3AT_2
Description:"band 3", SLC4A1 or AE1 gene.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:alternative promoter #2 of 2; 5' exon 1; site 2.; see alsoEP25042  
Tissues & Cell Lines:spleen, erythroid precursors
Experiment Methods:Nuclease protection; Primer extension
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3711102,226,451 - 102,226,511EPD
MGSCv3611102,226,451 - 102,226,511EPD
RGD ID:6849682
Promoter ID:EP25042
Type:single initiation site
Name:MM_B3AT_1
Description:"band 3", Major integral glycoprotein, SLC4A1 or AE1 gene.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:alternative promoter #1 of 2; 5' exon 1; site 1.; see alsoEP25043  
Tissues & Cell Lines:spleen, kidney
Experiment Methods:Nuclease protection; Primer extension
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3711102,226,563 - 102,226,623EPD
MGSCv3611102,226,563 - 102,226,623EPD
RGD ID:8676886
Promoter ID:EPDNEW_M16473
Type:initiation region
Name:Slc4a1_1
Description:Mus musculus solute carrier family 4 , member 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3811102,365,137 - 102,365,197EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:109393 AgrOrtholog
Ensembl Genes ENSMUSG00000006574 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000006749 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000006749 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.930.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Anion_exchange UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Anion_exchange_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Anion_exchange_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Band3_cytoplasmic_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HCO3_transpt_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HCO3_transpt_euk UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTrfase/Anion_transptr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:20533 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:109393 ENTREZGENE
NCBI Gene 20533 ENTREZGENE
PANTHER PTHR11453 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Band_3_cyto UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HCO3_cotransp UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Slc4a1 PhenoGen
PRINTS ANIONEXCHNGR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANIONEXHNGR1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HCO3TRNSPORT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ANION_EXCHANGER_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANION_EXCHANGER_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF55804 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs TIGR00834 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B3AT_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3TA19_MOUSE UniProtKB/TrEMBL
  Q3TAJ4_MOUSE UniProtKB/TrEMBL
  Q3TNH7_MOUSE UniProtKB/TrEMBL
  Q3TNL6_MOUSE UniProtKB/TrEMBL
  Q3TZ12_MOUSE UniProtKB/TrEMBL
  Q3TZ29 ENTREZGENE, UniProtKB/TrEMBL
  Q3TZG9_MOUSE UniProtKB/TrEMBL
  Q3TZJ1_MOUSE UniProtKB/TrEMBL
  Q3U065_MOUSE UniProtKB/TrEMBL
  Q53ZN9 ENTREZGENE, UniProtKB/TrEMBL