F11 (coagulation factor XI) - Rat Genome Database
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Gene: F11 (coagulation factor XI) Mus musculus
Analyze
Symbol: F11
Name: coagulation factor XI
RGD ID: 1319674
MGI Page MGI
Description: Predicted to have identical protein binding activity and serine-type aminopeptidase activity. Involved in regulation of blood coagulation. Predicted to localize to extracellular space. Is expressed in liver left lobe and liver right lobe. Used to study factor XI deficiency. Human ortholog(s) of this gene implicated in factor XI deficiency and thrombosis. Orthologous to human F11 (coagulation factor XI).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 1600027G01Rik; AI503996; Cf11; FX; FXI; plasma thromboplastin antecedent; PTA
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39845,693,696 - 45,715,092 (-)NCBIGRCm39mm39
GRCm39 Ensembl845,694,211 - 45,715,068 (-)Ensembl
GRCm38845,240,659 - 45,262,055 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl845,241,174 - 45,262,031 (-)EnsemblGRCm38mm10GRCm38
MGSCv37846,326,524 - 46,347,385 (-)NCBIGRCm37mm9NCBIm37
MGSCv36846,739,987 - 46,760,848 (-)NCBImm8
Celera847,928,261 - 47,949,034 (-)NCBICelera
Cytogenetic Map8B1.1NCBI
cM Map825.14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
1. Asakai R, etal., Proc Natl Acad Sci U S A. 1989 Oct;86(20):7667-71.
2. de Haan M, etal., Am J Med Genet. 1988 Feb;29(2):277-82.
3. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
4. Kleinschnitz C, etal., J Exp Med. 2006 Mar 20;203(3):513-8. Epub 2006 Mar 13.
5. Laudes IJ, etal., Am J Pathol. 2002 May;160(5):1867-75.
6. Li Y, etal., J Thromb Haemost. 2009 Nov;7(11):1802-8. doi: 10.1111/j.1538-7836.2009.03544.x. Epub 2009 Jul 6.
7. Lunghi B, etal., Thromb Res. 2012 Sep;130(3):563-4. doi: 10.1016/j.thromres.2012.05.004. Epub 2012 May 25.
8. Meijers JC, etal., N Engl J Med. 2000 Mar 9;342(10):696-701.
9. MGD data from the GO Consortium
10. Nobukata H, etal., Toxicol Lett. 1999 Jan 11;104(1-2):93-101.
11. Norris LA, Best Pract Res Clin Obstet Gynaecol. 2003 Jun;17(3):369-83.
12. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
13. OMIM Disease Annotation Pipeline
14. Pipeline to import KEGG annotations from KEGG into RGD
15. Pipeline to import SMPDB annotations from SMPDB into RGD
16. RGD automated import pipeline
17. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. RGD automated import pipeline for gene-chemical interactions
19. Sato E, etal., Am J Hematol. 2000 Apr;63(4):165-9.
20. Smith SA, etal., Crit Rev Biochem Mol Biol. 2015;50(4):326-36. doi: 10.3109/10409238.2015.1050550. Epub 2015 May 28.
21. Sokol J, etal., J Obstet Gynaecol. 2015;35(6):621-4. doi: 10.3109/01443615.2014.991284. Epub 2014 Dec 17.
22. Ventura C, etal., Thromb Haemost. 2000 Nov;84(5):833-40.
Additional References at PubMed
PMID:7613034   PMID:9242536   PMID:9518045   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11159184   PMID:11841337   PMID:12008966   PMID:12477932   PMID:15733058   PMID:15985536  
PMID:15996948   PMID:16009717   PMID:16141072   PMID:16141073   PMID:18491973   PMID:19661487   PMID:20005807   PMID:20634381   PMID:21267068   PMID:21724997   PMID:22006565   PMID:23472758  
PMID:23487423   PMID:23515926   PMID:23929304   PMID:24066149   PMID:24118982   PMID:24947525   PMID:26153520   PMID:26800563   PMID:26817955   PMID:27046148   PMID:27188843   PMID:27596064  
PMID:27913422   PMID:28148841   PMID:28492700   PMID:28677246   PMID:29207114   PMID:29365314   PMID:30591525   PMID:30898865   PMID:31125187  


Genomics

Comparative Map Data
F11
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39845,693,696 - 45,715,092 (-)NCBIGRCm39mm39
GRCm39 Ensembl845,694,211 - 45,715,068 (-)Ensembl
GRCm38845,240,659 - 45,262,055 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl845,241,174 - 45,262,031 (-)EnsemblGRCm38mm10GRCm38
MGSCv37846,326,524 - 46,347,385 (-)NCBIGRCm37mm9NCBIm37
MGSCv36846,739,987 - 46,760,848 (-)NCBImm8
Celera847,928,261 - 47,949,034 (-)NCBICelera
Cytogenetic Map8B1.1NCBI
cM Map825.14NCBI
F11
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl4186,265,945 - 186,288,806 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl4186,266,189 - 186,289,681 (+)EnsemblGRCh38hg38GRCh38
GRCh384186,265,964 - 186,290,727 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh374187,187,343 - 187,210,835 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364187,424,112 - 187,447,829 (+)NCBINCBI36hg18NCBI36
Build 344187,562,426 - 187,585,083NCBI
Celera4184,511,477 - 184,537,546 (+)NCBI
Cytogenetic Map4q35.2NCBI
HuRef4182,938,469 - 182,962,233 (+)NCBIHuRef
CHM1_14187,163,556 - 187,187,273 (+)NCBICHM1_1
F11
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21646,986,107 - 47,009,015 (+)NCBI
Rnor_6.0 Ensembl1650,179,458 - 50,201,698 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01650,179,458 - 50,201,644 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01649,902,415 - 49,924,601 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41650,276,330 - 50,298,903 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11650,287,001 - 50,298,978 (+)NCBI
Celera1644,976,615 - 44,998,530 (+)NCBICelera
Cytogenetic Map16q11NCBI
F11
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540322,811,380 - 22,830,563 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540322,811,211 - 22,830,281 (-)NCBIChiLan1.0ChiLan1.0
F11
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.14190,643,733 - 190,666,512 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4190,643,733 - 190,666,512 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v04178,436,865 - 178,459,568 (+)NCBIMhudiblu_PPA_v0panPan3
F11
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11644,469,609 - 44,492,833 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1644,469,632 - 44,540,292 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1644,956,542 - 44,972,975 (-)NCBI
ROS_Cfam_1.01646,683,089 - 46,700,923 (-)NCBI
UMICH_Zoey_3.11644,652,096 - 44,668,510 (-)NCBI
UNSW_CanFamBas_1.01645,264,846 - 45,281,307 (-)NCBI
UU_Cfam_GSD_1.01645,395,778 - 45,412,243 (-)NCBI
LOC101967202
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494334,886,563 - 34,903,578 (+)NCBI
SpeTri2.0NW_0049365543,205,539 - 3,223,228 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
F11
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl179,045,997 - 9,073,520 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1179,045,990 - 9,073,552 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
F11
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17132,180,026 - 132,207,081 (+)NCBI
ChlSab1.1 Ensembl7132,180,336 - 132,208,155 (+)Ensembl
F11
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476917,093,643 - 17,115,716 (+)NCBI

Position Markers
AI503996  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38845,241,234 - 45,241,486UniSTSGRCm38
MGSCv37846,326,588 - 46,326,840UniSTSGRCm37
Celera847,928,325 - 47,928,577UniSTS
Cytogenetic Map8A4UniSTS
Cytogenetic Map8B1.1UniSTS
Whitehead/MRC_RH8534.59UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558870Eae36_mexperimental allergic encephalomyelitis susceptibility 36 (mouse)Not determined81472316071045600Mouse
1301088Alcw6_malcohol withdrawal 6 (mouse)Not determined81501654449016701Mouse
1300912Daq19_mdirectional asymmetry QTL 19 (mouse)Not determined81501654449016701Mouse
1301298Pgia4_mproteoglycan induced arthritis 4 (mouse)Not determined81607934550079669Mouse
1301550Fembrs2_mfemur breaking strength 2 (mouse)Not determined81785394351854071Mouse
1301160Eae14_msusceptibility to experimental allergic encephalomyelitis 14 (mouse)Not determined81898786452987996Mouse
1300603Cd8ts2_mCD8 T cell subset 2 (mouse)Not determined81898786452987996Mouse
10043974Obq30_mobesity QTL 30 (mouse)Not determined82613028560130285Mouse
1357811Orq3_movulation rate QTL 3 (mouse)Not determined83201654471287993Mouse
4141437W10q14_mweight 10 weeks QTL 14 (mouse)Not determined3201654471287993Mouse
4141172W6q9_mweight 6 weeks QTL 9 (mouse)Not determined3201654471287993Mouse
4140966Egq12_mearly growth QTL 12 (mouse)Not determined3201654471287993Mouse
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832016544117238700Mouse
10043990Hbnr12_mHeligmosomoides bakeri nematode resistance 12 (mouse)Not determined83278698850837502Mouse
1301936Trigq2_mtriglyceride QTL 2 (mouse)Not determined83383736267837502Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined834642776114837007Mouse
1301139Lmr10_mleishmaniasis resistance 10 (mouse)Not determined83485394357344598Mouse
11041902Lmr10a_mleishmaniasis resistance 10a (mouse)83485394357344598Mouse
11049577Lmr10b_mleishmaniasis resistance 10b (mouse)83485394357344598Mouse
11049578Lmr10c_mleishmaniasis resistance 10c (mouse)83485394357344598Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83616300092728652Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837400000109600000Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)83970925694689598Mouse
1301544Iba3_minduction of brown adipocytes 3 (mouse)Not determined84429488078295025Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:83
Count of miRNA genes:75
Interacting mature miRNAs:76
Transcripts:ENSMUST00000034064
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000034064   ⟹   ENSMUSP00000034064
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl845,241,174 - 45,262,031 (-)Ensembl
RefSeq Acc Id: ENSMUST00000210622
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl845,250,073 - 45,262,031 (-)Ensembl
RefSeq Acc Id: NM_028066   ⟹   NP_082342
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39845,694,205 - 45,715,068 (-)NCBI
GRCm38845,241,168 - 45,262,031 (-)NCBI
MGSCv37846,326,524 - 46,347,385 (-)RGD
Celera847,928,261 - 47,949,034 (-)RGD
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006509244   ⟹   XP_006509307
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39845,693,696 - 45,715,087 (-)NCBI
GRCm38845,240,659 - 45,262,050 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006509245   ⟹   XP_006509308
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39845,693,696 - 45,708,324 (-)NCBI
GRCm38845,240,659 - 45,255,287 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011242172   ⟹   XP_011240474
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39845,693,696 - 45,706,148 (-)NCBI
GRCm38845,240,659 - 45,253,111 (-)NCBI
Sequence:
RefSeq Acc Id: XR_003947216
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39845,703,114 - 45,715,092 (-)NCBI
GRCm38845,250,077 - 45,262,055 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_082342   ⟸   NM_028066
- Peptide Label: preproprotein
- UniProtKB: Q91Y47 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006509307   ⟸   XM_006509244
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006509308   ⟸   XM_006509245
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_011240474   ⟸   XM_011242172
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSMUSP00000034064   ⟸   ENSMUST00000034064
Protein Domains
Apple   Peptidase S1

Promoters
RGD ID:8666985
Promoter ID:EPDNEW_M11523
Type:initiation region
Name:F11_1
Description:Mus musculus coagulation factor XI , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38845,261,986 - 45,262,046EPDNEW
RGD ID:6843110
Promoter ID:MM_KWN:54294
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:NM_028066
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36846,347,111 - 46,347,611 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:99481 AgrOrtholog
Ensembl Genes ENSMUSG00000031645 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000034064 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000034064 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000210622 ENTREZGENE
Gene3D-CATH 2.40.10.10 UniProtKB/Swiss-Prot
InterPro Apple UniProtKB/Swiss-Prot
  Pan_app UniProtKB/Swiss-Prot
  Peptidase_S1_PA UniProtKB/Swiss-Prot
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot
  Peptidase_S1A UniProtKB/Swiss-Prot
  Trypsin_dom UniProtKB/Swiss-Prot
  TRYPSIN_HIS UniProtKB/Swiss-Prot
  TRYPSIN_SER UniProtKB/Swiss-Prot
KEGG Report mmu:109821 UniProtKB/Swiss-Prot
MGD MGI:99481 ENTREZGENE
NCBI Gene 109821 ENTREZGENE
Pfam PAN_1 UniProtKB/Swiss-Prot
  Trypsin UniProtKB/Swiss-Prot
PhenoGen F11 PhenoGen
PRINTS APPLEDOMAIN UniProtKB/Swiss-Prot
  CHYMOTRYPSIN UniProtKB/Swiss-Prot
PROSITE APPLE UniProtKB/Swiss-Prot
  PAN UniProtKB/Swiss-Prot
  TRYPSIN_DOM UniProtKB/Swiss-Prot
  TRYPSIN_HIS UniProtKB/Swiss-Prot
  TRYPSIN_SER UniProtKB/Swiss-Prot
SMART APPLE UniProtKB/Swiss-Prot
  Tryp_SPc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50494 UniProtKB/Swiss-Prot
UniProt FA11_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q9DAT3 UniProtKB/Swiss-Prot