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Gene: F11 (coagulation factor XI) Mus musculus
Symbol: F11
Name: coagulation factor XI
Description: This gene encodes a glycoprotein coagulation factor that plays an important role in intrinsic pathway of blood coagulation and hemostasis. The encoded protein is an inactive zymogen that can be activated by coagulation factor XIIa, thrombin or factor XIa to generate active factor XIa protease. Mice lacking the encoded protein display a survival advantage during peritoneal sepsis and resist inflammation and bacterial accumulation upon infection with Listeria. [provided by RefSeq, Apr 2015]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 1600027G01Rik; AI503996; Cf11; FXI; plasma thromboplastin antecedent; PTA
Homo sapiens (human) : F11 (coagulation factor XI)  HGNC  Alliance
Rattus norvegicus (Norway rat) : F11 (coagulation factor XI)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : F11 (coagulation factor XI)
Pan paniscus (bonobo/pygmy chimpanzee) : F11 (coagulation factor XI)
Canis lupus familiaris (dog) : F11 (coagulation factor XI)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : F11 (coagulation factor XI)
Sus scrofa (pig) : F11 (coagulation factor XI)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38845,240,659 - 45,262,050 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37846,326,524 - 46,347,385 (-)NCBIGRCm37mm9NCBIm37
MGSCv36846,739,987 - 46,760,848 (-)NCBImm8
Celera847,928,261 - 47,949,034 (-)NCBICelera
Cytogenetic Map8 B1.1NCBI
cM Map825.14NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on F11
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1319674
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2019-06-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.