Cyba (cytochrome b-245, alpha polypeptide) - Rat Genome Database

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Gene: Cyba (cytochrome b-245, alpha polypeptide) Mus musculus
Analyze
Symbol: Cyba
Name: cytochrome b-245, alpha polypeptide
RGD ID: 734175
MGI Page MGI
Description: Predicted to enable SH3 domain binding activity; electron transfer activity; and protein heterodimerization activity. Predicted to contribute to superoxide-generating NAD(P)H oxidase activity. Involved in innate immune response. Acts upstream of or within positive regulation of mucus secretion; reactive oxygen species metabolic process; and regulation of release of sequestered calcium ion into cytosol. Located in endosome. Part of NADPH oxidase complex. Is expressed in several structures, including genitourinary system; hemolymphoid system; inner ear; limb; and liver. Human ortholog(s) of this gene implicated in artery disease (multiple); asthma; chronic obstructive pulmonary disease; and phagocyte bactericidal dysfunction (multiple). Orthologous to human CYBA (cytochrome b-245 alpha chain).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: b558; cytochrome b(558) alpha chain; cytochrome b-245 light chain; cytochrome b558 subunit alpha; cytochrome beta-558; neutrophil cytochrome b 22 kDa polypeptide; nmf333; p22 phagocyte B-cytochrome; p22 phox; p22-phox; p22phox; superoxide-generating NADPH oxidase light chain subunit
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398123,151,510 - 123,159,679 (-)NCBIGRCm39mm39
GRCm39 Ensembl8123,151,515 - 123,159,669 (-)Ensembl
GRCm388122,424,771 - 122,432,940 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8122,424,776 - 122,432,930 (-)EnsemblGRCm38mm10GRCm38
MGSCv378124,948,671 - 124,956,840 (-)NCBIGRCm37mm9NCBIm37
MGSCv368125,310,866 - 125,319,017 (-)NCBImm8
Celera8126,653,882 - 126,662,049 (-)NCBICelera
Cytogenetic Map8E1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1-naphthyl isothiocyanate  (ISO)
11-deoxycorticosterone  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-amino-2-deoxy-D-galactopyranose  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-hydroxypropanoic acid  (ISO)
3-chloropropane-1,2-diol  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxy-TEMPO  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (EXP)
acetamide  (ISO)
aflatoxin B1  (ISO)
AICA ribonucleotide  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP,ISO)
aminoguanidine  (ISO)
amlodipine  (ISO)
ammonium chloride  (ISO)
anagliptin  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antirheumatic drug  (ISO)
apocynin  (EXP,ISO)
aristolochic acid  (ISO)
Aroclor 1254  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atorvastatin calcium  (ISO)
benzo[a]pyrene  (EXP,ISO)
beta-D-glucosamine  (ISO)
bezafibrate  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bortezomib  (ISO)
butan-1-ol  (ISO)
Butylparaben  (ISO)
C60 fullerene  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
candesartan  (ISO)
canrenoic acid  (ISO)
carbon nanotube  (EXP)
chloropicrin  (ISO)
choline  (EXP)
chromium(6+)  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
cobalt dichloride  (EXP)
cocaine  (EXP)
crocidolite asbestos  (EXP)
Cuprizon  (ISO)
cyclosporin A  (ISO)
cytarabine  (ISO)
D-glucose  (ISO)
daunorubicin  (ISO)
DDE  (ISO)
decabromodiphenyl ether  (ISO)
dehydroepiandrosterone  (ISO)
Deoxycorticosterone acetate  (EXP)
dextran sulfate  (EXP)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibenziodolium  (EXP)
diclofenac  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
enalapril  (EXP)
endosulfan  (ISO)
eplerenone  (ISO)
ethanol  (EXP,ISO)
farrerol  (ISO)
fenamidone  (EXP)
flavonoids  (ISO)
folic acid  (EXP)
furan  (ISO)
genistein  (EXP,ISO)
gentamycin  (ISO)
ginsenoside Re  (EXP)
glucose  (ISO)
GW 6471  (ISO)
hexadecanoic acid  (ISO)
hydrochlorothiazide  (ISO)
hydrogen peroxide  (ISO)
iron dextran  (ISO)
isobutanol  (ISO)
isoprenaline  (ISO)
ketamine  (EXP)
L-ascorbic acid  (ISO)
L-methionine  (EXP)
Lasiocarpine  (ISO)
lipopolysaccharide  (EXP,ISO)
loganin  (EXP)
lutein  (EXP)
manidipine  (ISO)
menadione  (EXP)
mercury dichloride  (ISO)
metformin  (ISO)
methanol  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
N-acetyl-L-cysteine  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosomorpholine  (ISO)
N-Nitrosopyrrolidine  (ISO)
naringin  (ISO)
nebivolol  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
nicotinamide  (ISO)
nicotinic acid  (ISO)
O-methyleugenol  (ISO)
ochratoxin A  (ISO)
olmesartan  (ISO)
oxalic acid  (ISO)
oxycodone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
paricalcitol  (EXP)
phencyclidine  (EXP)
phenethyl caffeate  (ISO)
phenol  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pioglitazone  (EXP,ISO)
pirinixic acid  (EXP)
potassium chromate  (ISO)
pravastatin  (ISO)
probenecid  (ISO)
progesterone  (EXP)
quercetin  (ISO)
rac-lactic acid  (ISO)
ramipril  (EXP,ISO)
reactive oxygen species  (ISO)
resveratrol  (EXP,ISO)
rosuvastatin calcium  (ISO)
rotenone  (EXP,ISO)
SB 203580  (EXP)
silicon dioxide  (ISO)
simvastatin  (ISO)
sirolimus  (ISO)
sirtinol  (ISO)
sodium arsenite  (ISO)
sodium chloride  (EXP,ISO)
sodium fluoride  (ISO)
Soman  (ISO)
streptozocin  (ISO)
sunitinib  (ISO)
superoxide  (ISO)
tacrolimus hydrate  (ISO)
tamibarotene  (ISO)
tamoxifen  (EXP)
tebuconazole  (ISO)
telmisartan  (EXP,ISO)
testosterone  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
trandolapril  (ISO)
triphenyl phosphate  (ISO)
triphenylstannane  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
vinclozolin  (ISO)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to amino acid stimulus  (ISO)
cellular response to angiotensin  (ISO)
cellular response to gamma radiation  (ISO)
cellular response to glucose stimulus  (ISO)
cellular response to L-glutamine  (ISO)
cellular response to mechanical stimulus  (ISO)
cellular response to organic cyclic compound  (ISO)
cellular response to organic substance  (ISO)
cellular response to tumor necrosis factor  (ISO)
cytochrome complex assembly  (ISO)
establishment of localization in cell  (IMP)
hydrogen peroxide biosynthetic process  (ISO)
inflammatory response  (ISO)
innate immune response  (IMP,ISO)
mucus secretion  (IMP)
negative regulation of glomerular filtration by angiotensin  (ISO)
positive regulation of blood pressure  (ISO)
positive regulation of cell growth  (ISO)
positive regulation of defense response to bacterium  (ISO)
positive regulation of endothelial cell proliferation  (ISO)
positive regulation of interleukin-6 production  (ISO)
positive regulation of mucus secretion  (IMP)
positive regulation of NAD(P)H oxidase activity  (ISO)
positive regulation of oxygen metabolic process  (IMP)
positive regulation of phagocytosis  (ISO)
positive regulation of reactive oxygen species biosynthetic process  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of superoxide anion generation  (ISO)
positive regulation of toll-like receptor 2 signaling pathway  (ISO)
positive regulation of tumor necrosis factor production  (ISO)
reactive oxygen species metabolic process  (IMP)
regulation of release of sequestered calcium ion into cytosol  (IMP)
respiratory burst  (ISO)
response to activity  (ISO)
response to aldosterone  (ISO)
response to hypoxia  (ISO)
response to interleukin-1  (ISO)
response to nutrient levels  (ISO)
response to xenobiotic stimulus  (ISO)
smooth muscle hypertrophy  (ISO)
superoxide anion generation  (IBA,ISO)
superoxide metabolic process  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
2. Expression of two temporally distinct microglia-related gene clusters after spinal cord injury. Byrnes KR, etal., Glia. 2006 Mar;53(4):420-33.
3. NIACIN AMELIORATES OXIDATIVE STRESS, INFLAMMATION, PROTEINURIA, AND HYPERTENSION IN RATS WITH CHRONIC RENAL FAILURE. Cho KH, etal., Am J Physiol Renal Physiol. 2009 May 6.
4. Cytochrome b558-negative, autosomal recessive chronic granulomatous disease: two new mutations in the cytochrome b558 light chain of the NADPH oxidase (p22-phox). de Boer M, etal., Am J Hum Genet. 1992 Nov;51(5):1127-35.
5. Oxidative stress contributes to pulmonary hypertension in the transgenic (mRen2)27 rat. DeMarco VG, etal., Am J Physiol Heart Circ Physiol. 2008 Jun;294(6):H2659-68. Epub 2008 Apr 18.
6. Human neutrophil cytochrome b light chain (p22-phox). Gene structure, chromosomal location, and mutations in cytochrome-negative autosomal recessive chronic granulomatous disease. Dinauer MC, etal., J Clin Invest 1990 Nov;86(5):1729-37.
7. Expression of p22-phox and gp91-phox, essential components of NADPH oxidase, increases after myocardial infarction. Fukui T, etal., Biochem Biophys Res Commun. 2001 Mar;281(5):1200-6.
8. Role of kallistatin in prevention of cardiac remodeling after chronic myocardial infarction. Gao L, etal., Lab Invest. 2008 Nov;88(11):1157-66. Epub 2008 Sep 1.
9. The p22 phox A640G gene polymorphism but not the C242T gene variation is associated with coronary heart disease in younger individuals. Gardemann A, etal., Atherosclerosis. 1999 Aug;145(2):315-23.
10. [Expression of WAVE1 and p22phox in children with acute lymphocytic leukemia and the relationship of WAVE1 with oxidative stress]. He YL, etal., Zhongguo Dang Dai Er Ke Za Zhi. 2009 Feb;11(2):88-92.
11. Haplotype analysis of the NADPH oxidase p22 phox gene in patients with bronchial asthma. Izakovicova Holla L, etal., Int Arch Allergy Immunol. 2009;148(1):73-80. Epub 2008 Aug 21.
12. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
13. Role of AT1 receptors and NAD(P)H oxidase in diabetes-aggravated ischemic brain injury. Kusaka I, etal., Am J Physiol Heart Circ Physiol. 2004 Jun;286(6):H2442-51.
14. Genetic polymorphisms and susceptibility to lung disease. Lee PL, etal., J Negat Results Biomed. 2006 Apr 11;5:5.
15. Relationship between reduced nicotinamide adenine dinucleotide phosphate oxidase subunit p22phox gene polymorphism and obstructive sleep apnea-hypopnea syndrome in the Chinese Han population. Liu HG, etal., Chin Med J (Engl). 2009 Jun 20;122(12):1369-74.
16. [Nicotinamide-adenine dinucleotide phosphate oxidase p22phox expression in induced sputum cells for patients with obstructive sleep apnea hypopnea syndrome.] Liu HG, etal., Zhonghua Jie He He Hu Xi Za Zhi. 2010 Feb;33(2):118-22.
17. Relation between development of nephropathy and the p22phox C242T and receptor for advanced glycation end product G1704T gene polymorphisms in type 2 diabetic patients. Matsunaga-Irie S, etal., Diabetes Care. 2004 Feb;27(2):303-7.
18. MGDs mouse GO annotations MGD data from the GO Consortium
19. Preliminary characterisation of the promoter of the human p22(phox) gene: identification of a new polymorphism associated with hypertension. Moreno MU, etal., FEBS Lett. 2003 May 8;542(1-3):27-31.
20. Pivotal Advance: Eosinophilia in the MES rat strain is caused by a loss-of-function mutation in the gene for cytochrome b(-245), alpha polypeptide (Cyba). Mori M, etal., J Leukoc Biol. 2009 Sep;86(3):473-8. doi: 10.1189/jlb.1108715. Epub 2009 Apr 30.
21. The role of NADPH oxidase in chronic intermittent hypoxia-induced pulmonary hypertension in mice. Nisbet RE, etal., Am J Respir Cell Mol Biol. 2009 May;40(5):601-9. Epub 2008 Oct 23.
22. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
23. Apocynin restores endothelial dysfunction in streptozotocin diabetic rats through regulation of nitric oxide synthase and NADPH oxidase expressions. Olukman M, etal., J Diabetes Complications. 2010 Mar 10.
24. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
25. Uremia induces abnormal oxygen consumption in tubules and aggravates chronic hypoxia of the kidney via oxidative stress. Palm F, etal., Am J Physiol Renal Physiol. 2010 Aug;299(2):F380-6. doi: 10.1152/ajprenal.00175.2010. Epub 2010 Jun 2.
26. Tumor necrosis factor-alpha induces endothelial dysfunction in the prediabetic metabolic syndrome. Picchi A, etal., Circ Res. 2006 Jul 7;99(1):69-77. Epub 2006 Jun 1.
27. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
28. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
29. [Polymorphism -930A > G of the cytochrome b gene is a novel genetic marker of predisposition to bronchial asthma] Polonikov AV, etal., Ter Arkh. 2009;81(3):31-5.
30. Mouse MP Annotation Import Pipeline RGD automated import pipeline
31. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
32. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
33. Asymmetric dimethylarginine in angiotensin II-induced hypertension. Sasser JM, etal., Am J Physiol Regul Integr Comp Physiol. 2010 Mar;298(3):R740-6. Epub 2009 Dec 16.
34. Possible role of exogenous cAMP to improve vascular endothelial dysfunction in hypertensive rats. Shah DI and Singh M, Fundam Clin Pharmacol. 2006 Dec;20(6):595-604.
35. Association of gene polymorphisms with coronary artery disease in individuals with or without nonfamilial hypercholesterolemia. Shimokata K, etal., Atherosclerosis. 2004 Jan;172(1):167-73.
36. Characterization of six novel mutations in CYBA: the gene causing autosomal recessive chronic granulomatous disease. Teimourian S, etal., Br J Haematol. 2008 Jun;141(6):848-51. Epub 2008 Apr 18.
37. BN.MES-Cyba(mes) congenic rats manifest focal necrosis with eosinophilic infiltration in the liver without blood eosinophilia. Tomozawa H, etal., Exp Anim. 2010;59(4):469-78.
38. Genes for difference in eosinophilic phenotype between MES and BN.MES-Cyba(mes) rats are on chromosomes 9, 5, and 1. Tomozawa H, etal., Exp Anim. 2011;60(2):151-60.
39. CYP1A1, CYP1A2 and CYBA gene polymorphisms associated with oxidative stress in COPD. Vibhuti A, etal., Clin Chim Acta. 2010 Apr 2;411(7-8):474-80. Epub 2010 Jan 18.
40. [Effect of danzhi jiangtang capsule combined exercise on the protein expression of NADPH oxidase p22phox in pancreatic tissues of diabetic rats]. Wu YJ, etal., Zhongguo Zhong Xi Yi Jie He Za Zhi. 2013 May;33(5):641-5.
41. Genetic studies of three Japanese patients with p22-phox-deficient chronic granulomatous disease: detection of a possible common mutant CYBA allele in Japan and a genotype-phenotype correlation in these patients. Yamada M, etal., Br J Haematol. 2000 Mar;108(3):511-7.
42. Protective role of pigment epithelium-derived factor (PEDF) in early phase of experimental diabetic retinopathy. Yoshida Y, etal., Diabetes Metab Res Rev. 2009 Oct;25(7):678-86.
Additional References at PubMed
PMID:2597164   PMID:9507200   PMID:10349636   PMID:10447107   PMID:10922068   PMID:11042159   PMID:11076861   PMID:12477932   PMID:14610273   PMID:14651853   PMID:15123630   PMID:15345488  
PMID:15471976   PMID:15489334   PMID:15731028   PMID:15782199   PMID:15850784   PMID:16141072   PMID:16141073   PMID:16602821   PMID:16973969   PMID:17140397   PMID:17443690   PMID:18182394  
PMID:18287559   PMID:18292807   PMID:18417717   PMID:18665154   PMID:18799693   PMID:19136702   PMID:19201887   PMID:19283362   PMID:19641494   PMID:19755709   PMID:20195241   PMID:20454568  
PMID:21212270   PMID:21282379   PMID:21551061   PMID:21677136   PMID:21677750   PMID:21873635   PMID:22075471   PMID:23248154   PMID:24035466   PMID:24185898   PMID:24486509   PMID:24550188  
PMID:24739962   PMID:26036345   PMID:26108185   PMID:26297224   PMID:27117405   PMID:27689697   PMID:27863990   PMID:28138551   PMID:28351984   PMID:28510479   PMID:28729471   PMID:30062795  
PMID:30755476   PMID:30938680   PMID:31919083   PMID:32000019   PMID:32483169   PMID:33052238   PMID:34085299   PMID:34445407  


Genomics

Comparative Map Data
Cyba
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398123,151,510 - 123,159,679 (-)NCBIGRCm39mm39
GRCm39 Ensembl8123,151,515 - 123,159,669 (-)Ensembl
GRCm388122,424,771 - 122,432,940 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8122,424,776 - 122,432,930 (-)EnsemblGRCm38mm10GRCm38
MGSCv378124,948,671 - 124,956,840 (-)NCBIGRCm37mm9NCBIm37
MGSCv368125,310,866 - 125,319,017 (-)NCBImm8
Celera8126,653,882 - 126,662,049 (-)NCBICelera
Cytogenetic Map8E1NCBI
CYBA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381688,643,289 - 88,651,053 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1688,643,275 - 88,651,083 (-)EnsemblGRCh38hg38GRCh38
GRCh371688,709,697 - 88,717,461 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361687,237,198 - 87,244,958 (-)NCBINCBI36hg18NCBI36
Build 341687,237,198 - 87,244,950NCBI
Celera1673,779,369 - 73,787,129 (-)NCBI
Cytogenetic Map16q24.2NCBI
HuRef1674,403,728 - 74,411,523 (-)NCBIHuRef
CHM1_11690,120,999 - 90,128,842 (-)NCBICHM1_1
T2T-CHM13v2.01694,711,169 - 94,718,983 (-)NCBI
Cyba
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21950,487,598 - 50,495,669 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1950,487,597 - 50,495,721 (-)Ensembl
Rnor_6.01955,249,634 - 55,257,824 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1955,249,616 - 55,257,876 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01965,959,818 - 65,967,224 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41952,713,150 - 52,721,609 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11952,718,030 - 52,726,490 (-)NCBI
Celera1949,727,142 - 49,735,154 (-)NCBICelera
Cytogenetic Map19q12NCBI
LOC102004641
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555412,569,727 - 2,574,118 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555412,570,843 - 2,573,822 (-)NCBIChiLan1.0ChiLan1.0
LOC100986914
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11689,016,349 - 89,024,719 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1689,016,349 - 89,024,719 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01669,356,396 - 69,364,225 (-)NCBIMhudiblu_PPA_v0panPan3
CYBA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1564,692,865 - 64,701,056 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl564,692,123 - 64,704,893 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha564,703,545 - 64,711,735 (+)NCBI
ROS_Cfam_1.0564,912,202 - 64,920,393 (+)NCBI
ROS_Cfam_1.0 Ensembl564,911,577 - 64,920,464 (+)Ensembl
UMICH_Zoey_3.1564,938,335 - 64,946,503 (+)NCBI
UNSW_CanFamBas_1.0564,770,091 - 64,778,279 (+)NCBI
UU_Cfam_GSD_1.0565,176,122 - 65,184,313 (+)NCBI
LOC101967032
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934925,283,408 - 25,291,407 (+)NCBI
SpeTri2.0NW_0049366411,036,967 - 1,044,954 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CYBA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl61,015,162 - 1,021,420 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.161,015,212 - 1,021,422 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
LOC103233451
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1574,023,134 - 74,030,793 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl574,023,082 - 74,030,750 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660471,654,155 - 1,661,751 (+)NCBIVero_WHO_p1.0
LOC101717043
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624746911,842 - 919,362 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_004624746911,852 - 919,361 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
RH126425  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm388122,433,603 - 122,433,802UniSTSGRCm38
MGSCv378124,957,503 - 124,957,702UniSTSGRCm37
Celera8126,662,712 - 126,662,911UniSTS
Cytogenetic Map8E1UniSTS
Whitehead/MRC_RH81422.68UniSTS
Cyba  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map8E1UniSTS
Cytogenetic Map5B2UniSTS
Cytogenetic Map5G3UniSTS
cM Map871.04UniSTS


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357708Orq1_movulation rate QTL 1 (mouse)Not determined871740461124622354Mouse
4142023W3q5_mweight 3 weeks QTL 5 (mouse)Not determined71740461124622354Mouse
27095912Pglq14_mpelvic girdle length QTL 14, 16 week (mouse)874126628126826739Mouse
27226796Scvln16_msacral vertebrae length 2, 16 week (mouse)889726628130027694Mouse
1357494Obsty2_mobesity 2 (mouse)Not determined896245241129745061Mouse
12880431Fgf23lq2_mFGF23 serum level QTL 2 (mouse)897626632130127694Mouse
11252141Fdr2_mfat response to dietary restriction 2 (mouse)898390634130127694Mouse
1301481Lith11_mlithogenic gene 11 (mouse)Not determined898563635130127694Mouse
1302105Im1_mImmunoregulatory 1 (mouse)Not determined899828531130127694Mouse
1301080Sluc9_msusceptibility to lung cancer 9 (mouse)Not determined899828531130127694Mouse
4141435Fbtq3_mfemoral bone trait QTL 3 (mouse)Not determined8100965309130127694Mouse
1301316Dntcs1_mdental caries susceptibility 1 (mouse)Not determined8103443553127781786Mouse
11532691Sluc38_msusceptibility to lung cancer 38 (mouse)8105033977130127694Mouse
11532692Sluc38a_msusceptibility to lung cancer 38a (mouse)8105033977130127694Mouse
14746994Manh65_mmandible shape 65 (mouse)8106489629130127694Mouse
10412273Fcd1_mfunctional capillary density 1 (mouse)Not determined8110415083130127694Mouse
10412274Leci1_mleukocyte endothelial cell interactions 1 (mouse)Not determined8110415083130127694Mouse
12904938Edlmmq7_mextensor digitorum longus muscle mass QTL 7 (mouse)8111481497130127694Mouse
12904960Gmmq6_mgastrocnemius muscle mass QTL 6 (mouse)8111481497130127694Mouse
4141546Mrdq3_mmodifier of retinal degeneration QTL 3 (mouse)Not determined114439420126055880Mouse
26884375Skwq2_mskull length QTL 2, 5 week (mouse)8120726739130027694Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:166
Count of miRNA genes:153
Interacting mature miRNAs:162
Transcripts:ENSMUST00000017604
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001301284 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_007806 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AK018713 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK021200 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK078854 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK131580 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK152414 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK154184 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK171748 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK190653 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL591003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC026791 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC060635 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY005999 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CF738398 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466525 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU791539 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M31775 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000017604   ⟹   ENSMUSP00000017604
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl8123,151,515 - 123,159,669 (-)Ensembl
GRCm38.p6 Ensembl8122,424,776 - 122,432,930 (-)Ensembl
RefSeq Acc Id: ENSMUST00000212600   ⟹   ENSMUSP00000148320
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl8123,151,515 - 123,159,647 (-)Ensembl
GRCm38.p6 Ensembl8122,424,776 - 122,432,908 (-)Ensembl
RefSeq Acc Id: ENSMUST00000212822
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl8123,152,945 - 123,159,644 (-)Ensembl
GRCm38.p6 Ensembl8122,426,206 - 122,432,905 (-)Ensembl
RefSeq Acc Id: NM_001301284   ⟹   NP_001288213
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm398123,151,510 - 123,159,679 (-)NCBI
GRCm388122,424,771 - 122,432,940 (-)NCBI
Celera8126,653,882 - 126,662,049 (-)NCBI
Sequence:
RefSeq Acc Id: NM_007806   ⟹   NP_031832
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm398123,151,510 - 123,159,679 (-)NCBI
GRCm388122,424,771 - 122,432,940 (-)NCBI
MGSCv378124,948,671 - 124,956,840 (-)RGD
Celera8126,653,882 - 126,662,049 (-)RGD
cM Map8 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_031832   ⟸   NM_007806
- Peptide Label: isoform 1
- UniProtKB: Q61462 (UniProtKB/Swiss-Prot),   B3VQI8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001288213   ⟸   NM_001301284
- Peptide Label: isoform 2
- UniProtKB: Q61462 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000017604   ⟸   ENSMUST00000017604
RefSeq Acc Id: ENSMUSP00000148320   ⟸   ENSMUST00000212600

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q61462-F1-model_v2 AlphaFold Q61462 1-192 view protein structure

Promoters
RGD ID:8668511
Promoter ID:EPDNEW_M12287
Type:initiation region
Name:Cyba_1
Description:Mus musculus cytochrome b-245, alpha polypeptide , transcriptvariant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm388122,432,908 - 122,432,968EPDNEW
RGD ID:6848276
Promoter ID:MM_ACW:49178
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_4Hour
Transcripts:CYBA.HSEP07-UNSPLICED
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv368124,949,956 - 124,950,456 (-)MPROMDB
RGD ID:6842741
Promoter ID:MM_KWN:55991
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_007806,   UC009NSQ.1,   UC009NSR.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv368124,954,486 - 124,957,817 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1316658 AgrOrtholog
Ensembl Genes ENSMUSG00000006519 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000017604 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000148320 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000017604 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000212600 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro Cyt_b558_asu UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:13057 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1316658 ENTREZGENE
NCBI Gene 13057 ENTREZGENE
PANTHER PTHR15168 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Cytochrom_B558a UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cyba PhenoGen
PIRSF Cytochr_b558a UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B3VQI8 ENTREZGENE, UniProtKB/TrEMBL
  CY24A_MOUSE UniProtKB/Swiss-Prot
  Q3TAM0_MOUSE UniProtKB/TrEMBL
  Q61462 ENTREZGENE
  Q8C5D4_MOUSE UniProtKB/TrEMBL
UniProt Secondary Q3U820 UniProtKB/Swiss-Prot
  Q9CWB9 UniProtKB/Swiss-Prot
  Q9D2W2 UniProtKB/Swiss-Prot