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Gene: Rad50 (RAD50 double strand break repair protein) Mus musculus
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Symbol: Rad50
Name: RAD50 double strand break repair protein
Description: Predicted to contribute to 3'-5' exonuclease activity; DNA helicase activity; and single-stranded DNA endodeoxyribonuclease activity. Involved in chromosome organization involved in meiotic cell cycle and regulation of mitotic cell cycle. Localizes to pronucleus. Is expressed in several structures, including aorta; hemolymphoid system gland; liver; lung; and testis. Human ortholog(s) of this gene implicated in transitional cell carcinoma. Orthologous to human RAD50 (RAD50 double strand break repair protein); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; homologous recombination pathway of double-strand break repair; non-homologous end joining pathway of double-strand break repair; INTERACTS WITH (S)-nicotine; 1,2-dichloroethane; 1,2-dimethylhydrazine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: DNA repair protein RAD50; mRad50; Mrell; RAD50 homolog; Rad50l
Orthologs:
Homo sapiens (human) : RAD50 (RAD50 double strand break repair protein)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Rad50 (RAD50 double strand break repair protein)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Rad50 (RAD50 double strand break repair protein)
Pan paniscus (bonobo/pygmy chimpanzee) : RAD50 (RAD50 double strand break repair protein)
Canis lupus familiaris (dog) : RAD50 (RAD50 double strand break repair protein)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Rad50 (RAD50 double strand break repair protein)
Sus scrofa (pig) : RAD50 (RAD50 double strand break repair protein)
Chlorocebus sabaeus (African green monkey) : RAD50 (RAD50 double strand break repair protein)
Heterocephalus glaber (naked mole-rat) : Rad50 (RAD50 double strand break repair protein)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38.p6 Ensembl1153,649,519 - 53,707,319 (-)EnsemblGRCm38mm10GRCm38
GRCm381153,649,519 - 53,707,319 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371153,463,021 - 53,520,821 (-)NCBIGRCm37mm9NCBIm37
MGSCv361153,492,993 - 53,550,720 (-)NCBImm8
Celera1158,229,063 - 58,286,859 (-)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1131.98NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
Nomenclature History
 
More on Rad50
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 733900
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.