Rad50 (RAD50 double strand break repair protein) - Rat Genome Database

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Gene: Rad50 (RAD50 double strand break repair protein) Mus musculus
Analyze
Symbol: Rad50
Name: RAD50 double strand break repair protein
RGD ID: 733900
MGI Page MGI
Description: Predicted to enable several functions, including ATP hydrolysis activity; DNA binding activity; and protein serine/threonine kinase activator activity. Predicted to contribute to 3'-5' exonuclease activity; DNA helicase activity; and single-stranded DNA endodeoxyribonuclease activity. Acts upstream of or within chromosome organization involved in meiotic cell cycle and regulation of mitotic cell cycle. Located in pronucleus. Part of Mre11 complex. Is expressed in several structures, including aorta; genitourinary system; hemolymphoid system gland; liver; and lung. Human ortholog(s) of this gene implicated in transitional cell carcinoma. Orthologous to human RAD50 (RAD50 double strand break repair protein).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: DNA repair protein RAD50; Mr; mRad50; Mrell; Rad; RAD50 homolog; Rad50l
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391153,540,346 - 53,598,146 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1153,540,346 - 53,598,146 (-)EnsemblGRCm39 Ensembl
GRCm381153,649,519 - 53,707,319 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1153,649,519 - 53,707,319 (-)EnsemblGRCm38mm10GRCm38
MGSCv371153,463,021 - 53,520,821 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361153,492,993 - 53,550,720 (-)NCBIMGSCv36mm8
Celera1158,229,063 - 58,286,859 (-)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1131.98NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(S)-nicotine  (EXP,ISO)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
1,3-dinitrobenzene  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-methylcholine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroperoxycyclophosphamide  (ISO)
4-hydroxyphenyl retinamide  (EXP)
6-propyl-2-thiouracil  (ISO)
acrolein  (ISO)
aflatoxin B1  (EXP)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amitrole  (ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
amphibole asbestos  (ISO)
arecoline  (ISO)
Aroclor 1254  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (EXP)
arsenous acid  (ISO)
atrazine  (ISO)
benzene  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (ISO)
Brevetoxin B  (ISO)
bromoacetate  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP,ISO)
calcium dichloride  (ISO)
camptothecin  (ISO)
carbamazepine  (ISO)
chloroprene  (ISO)
chlorpyrifos  (EXP)
chromium(6+)  (ISO)
cisplatin  (EXP,ISO)
clorgyline  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
diclofenac  (ISO)
disodium selenite  (ISO)
erlotinib hydrochloride  (ISO)
fenofibrate  (ISO)
fenvalerate  (ISO)
ferric oxide  (EXP)
flavone  (ISO)
folic acid  (EXP)
FR900359  (ISO)
hydrogen peroxide  (ISO)
indole-3-methanol  (ISO)
isocyanates  (EXP)
ivermectin  (ISO)
kojic acid  (EXP)
L-ascorbic acid  (EXP)
lipopolysaccharide  (ISO)
lycopene  (ISO)
methimazole  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
Monobutylphthalate  (ISO)
monocrotaline  (EXP)
myristicin  (ISO)
N,N-dimethylformamide  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
nickel dichloride  (ISO)
nicotine  (EXP,ISO)
O-methyleugenol  (ISO)
oxybenzone  (ISO)
ozone  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenytoin  (EXP)
piperonyl butoxide  (ISO)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
potassium chromate  (ISO)
Ptaquiloside  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
retinyl acetate  (EXP)
rifampicin  (EXP)
rotenone  (ISO)
silicon dioxide  (ISO)
silver atom  (EXP)
silver(0)  (EXP)
sodium arsenite  (EXP,ISO)
sulfadimethoxine  (ISO)
tamibarotene  (ISO)
testosterone enanthate  (ISO)
tetrachloroethene  (ISO)
thapsigargin  (EXP)
thioacetamide  (ISO)
thiram  (ISO)
titanium dioxide  (EXP)
triphenyl phosphate  (ISO)
triptonide  (EXP)
troglitazone  (EXP,ISO)
trovafloxacin  (EXP)
usnic acid  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)
wortmannin  (ISO)
zinc pyrithione  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal airway resistance  (IAGP)
abnormal bone marrow cell morphology/development  (IAGP)
abnormal CD4-positive, alpha beta T cell morphology  (IAGP)
abnormal cell cycle checkpoint function  (IAGP)
abnormal developmental patterning  (IAGP)
abnormal DNA methylation  (IAGP)
abnormal fertility/fecundity  (IAGP)
abnormal gait  (IAGP)
abnormal gametogenesis  (IAGP)
abnormal hematopoietic stem cell morphology  (IAGP)
abnormal hematopoietic system morphology/development  (IAGP)
abnormal hematopoietic system physiology  (IAGP)
abnormal hepatocyte morphology  (IAGP)
abnormal immune system cell morphology  (IAGP)
abnormal immune system organ morphology  (IAGP)
abnormal intestine morphology  (IAGP)
abnormal pro-B cell morphology  (IAGP)
abnormal seminiferous tubule morphology  (IAGP)
abnormal sperm number  (IAGP)
abnormal spermatogenesis  (IAGP)
abnormal spleen morphology  (IAGP)
abnormal T-helper 1 physiology  (IAGP)
abnormal T-helper 2 physiology  (IAGP)
abnormal testis morphology  (IAGP)
abnormal testis size  (IAGP)
abnormal thymus morphology  (IAGP)
absent bone marrow cell  (IAGP)
anemia  (IAGP)
chromosome breakage  (IAGP)
decreased airway responsiveness  (IAGP)
decreased apoptosis  (IAGP)
decreased B cell number  (IAGP)
decreased body weight  (IAGP)
decreased bone marrow cell number  (IAGP)
decreased cell proliferation  (IAGP)
decreased double-negative T cell number  (IAGP)
decreased embryo size  (IAGP)
decreased hepatocyte proliferation  (IAGP)
decreased IgE level  (IAGP)
decreased immature B cell number  (IAGP)
decreased inflammatory response  (IAGP)
decreased interferon-gamma secretion  (IAGP)
decreased interleukin-13 secretion  (IAGP)
decreased interleukin-4 secretion  (IAGP)
decreased interleukin-5 secretion  (IAGP)
decreased litter size  (IAGP)
decreased macrophage cell number  (IAGP)
decreased pre-B cell number  (IAGP)
decreased pro-B cell number  (IAGP)
decreased T cell number  (IAGP)
embryonic growth arrest  (IAGP)
embryonic lethality between implantation and somite formation, complete penetrance  (IAGP)
female infertility  (IAGP)
hydrocephaly  (IAGP)
impaired hematopoiesis  (IAGP)
increased cellular sensitivity to gamma-irradiation  (IAGP)
increased cellular sensitivity to ionizing radiation  (IAGP)
increased foot pad pigmentation  (IAGP)
increased hepatoblastoma incidence  (IAGP)
increased interleukin-13 secretion  (IAGP)
increased interleukin-4 secretion  (IAGP)
increased interleukin-5 secretion  (IAGP)
increased late pro-B cell number  (IAGP)
increased leukemia incidence  (IAGP)
increased liver adenoma incidence  (IAGP)
increased liver tumor incidence  (IAGP)
increased lymphoma incidence  (IAGP)
increased macrophage cell number  (IAGP)
increased skin pigmentation  (IAGP)
increased T cell derived lymphoma incidence  (IAGP)
increased tail pigmentation  (IAGP)
increased tumor latency  (IAGP)
lethality throughout fetal growth and development, incomplete penetrance  (IAGP)
liver hypoplasia  (IAGP)
male infertility  (IAGP)
ovary atrophy  (IAGP)
pancytopenia  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
premature death  (IAGP)
prenatal lethality, complete penetrance  (IAGP)
reduced female fertility  (IAGP)
small testis  (IAGP)
spleen hyperplasia  (IAGP)
testicular atrophy  (IAGP)
thrombocytopenia  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Altered expression of DNA double-strand break detection and repair proteins in breast carcinomas. Angele S, etal., Histopathology. 2003 Oct;43(4):347-53.
2. ATM protein kinase: the linchpin of cellular defenses to stress. Bhatti S, etal., Cell Mol Life Sci. 2011 Sep;68(18):2977-3006. doi: 10.1007/s00018-011-0683-9. Epub 2011 May 2.
3. RAD50 and NBS1 are breast cancer susceptibility genes associated with genomic instability. Heikkinen K, etal., Carcinogenesis. 2006 Aug;27(8):1593-9. Epub 2006 Feb 12.
4. Regulation of homologous recombination in eukaryotes. Heyer WD, etal., Annu Rev Genet. 2010;44:113-39. doi: 10.1146/annurev-genet-051710-150955.
5. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
6. Antibody-array technique reveals overexpression of important DNA-repair proteins during cardiac ischemic preconditioning. Mathur P, etal., J Mol Cell Cardiol. 2005 Jan;38(1):99-102.
7. MGDs mouse GO annotations MGD data from the GO Consortium
8. MGD IEA MGD IEA
9. Microsatellite instability and mutation analysis of candidate genes in urothelial cell carcinomas of upper urinary tract. Mongiat-Artus P, etal., Oncogene. 2006 Mar 30;25(14):2113-8.
10. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
11. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. Mouse MP Annotation Import Pipeline RGD automated import pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Overexpressed human RAD50 exhibits cell death in a p21(WAF1/CIP1)-dependent manner: its potential utility in local gene therapy of tumor. Shin BA, etal., Cell Growth Differ. 2001 May;12(5):243-54.
17. Hepatoprotective effects and mechanisms of dehydrocavidine in rats with carbon tetrachloride-induced hepatic fibrosis. Wang T, etal., J Ethnopharmacol. 2011 Oct 31;138(1):76-84. doi: 10.1016/j.jep.2011.08.039. Epub 2011 Aug 24.
18. DNA damage: a trigger of innate immunity but a requirement for adaptive immune homeostasis. Xu Y Nat Rev Immunol. 2006 Apr;6(4):261-70.
Additional References at PubMed
PMID:8910585   PMID:9149945   PMID:10349636   PMID:10377422   PMID:10464095   PMID:10655497   PMID:10704283   PMID:10922068   PMID:11042159   PMID:11076861   PMID:12208847   PMID:12477932  
PMID:14610273   PMID:15378057   PMID:15489334   PMID:15507491   PMID:15589174   PMID:15608641   PMID:15615879   PMID:15734743   PMID:15880101   PMID:15965469   PMID:16141072   PMID:16141073  
PMID:16357220   PMID:17429352   PMID:17500065   PMID:17982445   PMID:18171670   PMID:18381424   PMID:18411308   PMID:18854157   PMID:19001091   PMID:19221393   PMID:19633670   PMID:19667071  
PMID:19910469   PMID:20086180   PMID:20483988   PMID:21267068   PMID:21677273   PMID:21677750   PMID:21725061   PMID:21873635   PMID:22027841   PMID:22369660   PMID:22771806   PMID:23248301  
PMID:23569250   PMID:23643835   PMID:23665500   PMID:23937658   PMID:24344331   PMID:24457600   PMID:24532689   PMID:24613343   PMID:24777530   PMID:25601756   PMID:26280532   PMID:26365490  
PMID:26512707   PMID:26961797   PMID:27034005   PMID:27746211   PMID:27878828   PMID:28132936   PMID:28671696   PMID:28819025   PMID:29091030   PMID:29459677   PMID:29709199   PMID:30017584  
PMID:30657944   PMID:32665583   PMID:33230847   PMID:33524014   PMID:33654053   PMID:35920200   PMID:36114006   PMID:36178098   PMID:38512324  


Genomics

Comparative Map Data
Rad50
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391153,540,346 - 53,598,146 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1153,540,346 - 53,598,146 (-)EnsemblGRCm39 Ensembl
GRCm381153,649,519 - 53,707,319 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1153,649,519 - 53,707,319 (-)EnsemblGRCm38mm10GRCm38
MGSCv371153,463,021 - 53,520,821 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361153,492,993 - 53,550,720 (-)NCBIMGSCv36mm8
Celera1158,229,063 - 58,286,859 (-)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1131.98NCBI
RAD50
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385132,556,977 - 132,646,349 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5132,556,019 - 132,646,349 (+)EnsemblGRCh38hg38GRCh38
GRCh375131,892,669 - 131,982,041 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365131,920,529 - 132,007,498 (+)NCBINCBI36Build 36hg18NCBI36
Build 345131,920,528 - 132,007,492NCBI
Celera5128,022,732 - 128,110,444 (+)NCBICelera
Cytogenetic Map5q31.1NCBI
HuRef5127,084,875 - 127,172,627 (+)NCBIHuRef
CHM1_15131,325,888 - 131,413,608 (+)NCBICHM1_1
T2T-CHM13v2.05133,076,780 - 133,166,151 (+)NCBIT2T-CHM13v2.0
Rad50
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81038,310,147 - 38,362,100 (-)NCBIGRCr8
mRatBN7.21037,809,353 - 37,861,309 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1037,808,726 - 37,861,396 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1042,501,288 - 42,553,213 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01041,991,358 - 42,043,283 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01037,495,080 - 37,547,005 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01039,002,130 - 39,054,042 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1039,001,498 - 39,054,142 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01038,783,860 - 38,835,810 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41039,112,733 - 39,164,694 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11039,121,979 - 39,173,935 (-)NCBI
Celera1037,153,558 - 37,205,520 (-)NCBICelera
Cytogenetic Map10q22NCBI
Rad50
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554083,953,800 - 4,035,494 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554083,953,801 - 4,035,494 (+)NCBIChiLan1.0ChiLan1.0
RAD50
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24127,867,909 - 127,955,144 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15126,007,455 - 126,094,708 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05127,972,630 - 128,059,911 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15134,134,506 - 134,222,261 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5134,134,495 - 134,222,261 (+)Ensemblpanpan1.1panPan2
RAD50
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11120,836,863 - 20,928,930 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1120,836,879 - 20,928,819 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1119,500,587 - 19,730,384 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01121,484,565 - 21,714,833 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1121,622,834 - 21,714,817 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11120,203,382 - 20,433,320 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01120,051,430 - 20,280,918 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01120,693,292 - 20,923,363 (+)NCBIUU_Cfam_GSD_1.0
Rad50
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213115,536,406 - 115,761,319 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366472,543,599 - 2,637,846 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366472,546,100 - 2,637,524 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RAD50
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2134,700,817 - 134,939,189 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12134,844,460 - 134,939,188 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22140,313,725 - 140,407,469 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RAD50
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12335,375,206 - 35,458,801 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2335,375,305 - 35,458,622 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603442,481,288 - 42,568,716 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rad50
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473339,447,461 - 39,544,409 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473339,445,083 - 39,544,415 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rad50
2069 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:973
Count of miRNA genes:559
Interacting mature miRNAs:671
Transcripts:ENSMUST00000020649, ENSMUST00000124352, ENSMUST00000126121, ENSMUST00000128483, ENSMUST00000152598
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357844Si5lq5_mserum IGFBP-5 level QTL 5 (mouse)Not determined112816587362165976Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44630038113058009Mouse
1357720Kidpq1_mkidney weight percentage QTL 1 (mouse)Not determined111226863768500330Mouse
1300765Bbaa4_mB.burgdorferi-associated arthritis 4 (mouse)Not determined114618516780185262Mouse
1357851Scfq3_msubcutaneous fat pad weight QTL 3 (mouse)Not determined111226863768500330Mouse
1301788Lbw8_mlupus NZB x NZW 8 (mouse)Not determined113650328770509492Mouse
27226762Feml21_mfemur length 21, 16 week (mouse)111175000065990826Mouse
1302021Nidd1n_mnon-insulin-dependent diabetes mellitus 1 in NSY (mouse)Not determined114516587379978324Mouse
1301896Tria1_mT-cell receptor induced activation 1 (mouse)Not determined113661356570613855Mouse
4141470Egq4_mearly growth QTL 4 (mouse)Not determined1226863768500330Mouse
1301426Desp2_mdespair 2 (mouse)Not determined112870858162708700Mouse
4142109W10q2_mweight 10 weeks QTL 2 (mouse)Not determined1226863768500330Mouse
4141853Skmw17_mskeletal muscle weight 17 (mouse)Not determined113708094171081064Mouse
1357878Mastr_mmodifier of astrocytoma (mouse)Not determined114570858189818733Mouse
13208559Wght10_mweight 10 (mouse)11395000088890826Mouse
13524840Ppiq9a_mprepulse inhibition QTL 9a (mouse)115249438586494385Mouse
13208558Lgth12_mbody length 12 (mouse)11395000094890826Mouse
26884401Huml4_mhumerus length 4, 10 week (mouse)111155000068490826Mouse
10053687Eae6_msusceptibility to experimental allergic encephalomyelitis 6 (mouse)Not determined111778196668500330Mouse
13208569Bmiq10_mbody mass index QTL 10 (mouse)113589082784890826Mouse
27226798Scvln18_msacral vertebrae length 2, 16 week (mouse)11325000060690826Mouse
4141582Lgaq1_mlate growth adjusted QTL 1 (mouse)Not determined1226863768500330Mouse
4141966Tailq1_mtail length QTL 1 (mouse)Not determined1226863768500330Mouse
10053675Eae44b_mexperimental allergic encephalomyelitis susceptibility 44b (mouse)Not determined113995072854094448Mouse
4142475Ity2a_mimmunity to S. typhimurium 2a (mouse)Not determined113776858060402716Mouse
11532699Sluc36b_msusceptibility to lung cancer 36b (mouse)114225661776256730Mouse
11532698Sluc36a_msusceptibility to lung cancer 36a (mouse)114225661776256730Mouse
1300774Pgia7_mproteoglycan induced arthritis 7 (mouse)Not determined115339058887390737Mouse
1558945Orgwq8_morgan weight QTL 8 (mouse)Not determined111705617567078411Mouse
4142216Lgq1_mlate growth QTL 1 (mouse)Not determined1226863768500330Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11688027789019734Mouse
14746971Manh70_mmandible shape 70 (mouse)111990589053905890Mouse
13524848Ppiq7_mprepulse inhibition QTL 7 (mouse)112856914762569147Mouse
1357782Char8_mP. chabaudi malaria resistance QTL 8 (mouse)Not determined113557861669684987Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
11059563Lmr31_mleishmaniasis resistance 31 (mouse)113210057766100694Mouse
1301328Mol4_mmodifier of LPS-response 4 (mouse)Not determined113628257783481356Mouse
26884446Sklq10_mskull length QTL 10, 10 week (mouse)11325000062890826Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112180736495881231Mouse
1559002Lmrq4_mLeishmania major resistance QTL 4 (mouse)Not determined111226863769684947Mouse
1301830Ssta4_msusceptibility to Salmonella typhimurium antigens 4 (mouse)Not determined115007819184078411Mouse
4142308W6q3_mweight 6 weeks QTL 3 (mouse)Not determined111226863768500330Mouse
1357640Orq2_movulation rate QTL 2 (mouse)Not determined111226863768500330Mouse
10766457Nwa3_mNew Zealand White autoimmunity 3 (mouse)113801611572016209Mouse
4142300Ctrq3_mC. trachomatis resistance QTL 3 (mouse)Not determined114463003876854757Mouse
1357437Epfq4_mepididymal fat pad weight QTL 4 (mouse)Not determined111226863768500330Mouse
4141398Tgq22_mtriglyceride QTL 22 (mouse)Not determined2116340655163406Mouse
27226738Metcl11_mmetatarsal-calcaneal length 11, 10 week (mouse)11885000061390826Mouse
11522752Cocia18_mcocaine-induced activity, QTL 18 (mouse)113100820965008209Mouse
4141770Tcpm1_mT-cell phenotype modifier 1 (mouse)Not determined5145247953615930Mouse
1301988Bmd11_mbone mineral density 11 (mouse)Not determined114631940780319522Mouse
4141127W3q4_mweight 3 weeks QTL 4 (mouse)Not determined1226863768500330Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1912420496897826Mouse
1300713Vmbic10_mventral midbrain iron content 10 (mouse)Not determined114277262654081064Mouse
26884453Sklq16_mskull length QTL 16, 16 week (mouse)11325000072690826Mouse
10044006Hbnr13_mHeligmosomoides bakeri nematode resistance 13 (mouse)Not determined112577262659772741Mouse

Markers in Region
Rad50  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11A5-B1UniSTS
cM Map1128.9UniSTS
stSG601375  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381153,692,124 - 53,692,840UniSTSGRCm38
MGSCv371153,505,626 - 53,506,342UniSTSGRCm37
Celera1158,271,663 - 58,272,380UniSTS
Cytogenetic Map11A5-B1UniSTS
Rad50  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11A5-B1UniSTS
cM Map1128.9UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000020649   ⟹   ENSMUSP00000020649
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1153,540,346 - 53,598,146 (-)Ensembl
GRCm38.p6 Ensembl1153,649,519 - 53,707,319 (-)Ensembl
Ensembl Acc Id: ENSMUST00000124352   ⟹   ENSMUSP00000119618
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1153,574,082 - 53,598,122 (-)Ensembl
GRCm38.p6 Ensembl1153,683,255 - 53,707,295 (-)Ensembl
Ensembl Acc Id: ENSMUST00000126121
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1153,569,662 - 53,571,039 (-)Ensembl
GRCm38.p6 Ensembl1153,678,835 - 53,680,212 (-)Ensembl
Ensembl Acc Id: ENSMUST00000128483   ⟹   ENSMUSP00000120869
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1153,565,582 - 53,598,146 (-)Ensembl
GRCm38.p6 Ensembl1153,674,755 - 53,707,319 (-)Ensembl
Ensembl Acc Id: ENSMUST00000152598
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1153,582,748 - 53,585,827 (-)Ensembl
GRCm38.p6 Ensembl1153,691,921 - 53,695,000 (-)Ensembl
RefSeq Acc Id: NM_009012   ⟹   NP_033038
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391153,540,346 - 53,598,146 (-)NCBI
GRCm381153,649,519 - 53,707,319 (-)ENTREZGENE
MGSCv371153,463,021 - 53,520,821 (-)RGD
Celera1158,229,063 - 58,286,859 (-)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_033038   ⟸   NM_009012
- UniProtKB: Q9CU59 (UniProtKB/Swiss-Prot),   Q8C2T7 (UniProtKB/Swiss-Prot),   Q6PEB0 (UniProtKB/Swiss-Prot),   P70388 (UniProtKB/Swiss-Prot),   Q5SV02 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000119618   ⟸   ENSMUST00000124352
Ensembl Acc Id: ENSMUSP00000020649   ⟸   ENSMUST00000020649
Ensembl Acc Id: ENSMUSP00000120869   ⟸   ENSMUST00000128483
Protein Domains
Rad50/SbcC-type AAA   Zinc-hook

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P70388-F1-model_v2 AlphaFold P70388 1-1312 view protein structure

Promoters
RGD ID:6821693
Promoter ID:MM_KWN:7399
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000102756,   ENSMUST00000108933,   NM_009012,   OTTMUST00000012556,   OTTMUST00000071546,   UC007IWU.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361153,520,326 - 53,520,977 (-)MPROMDB
RGD ID:8674622
Promoter ID:EPDNEW_M15342
Type:initiation region
Name:Rad50_1
Description:Mus musculus RAD50 double strand break repair protein , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381153,707,317 - 53,707,377EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:109292 AgrOrtholog
Ensembl Genes ENSMUSG00000020380 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000020649 ENTREZGENE
  ENSMUST00000020649.14 UniProtKB/TrEMBL
  ENSMUST00000124352.2 UniProtKB/TrEMBL
  ENSMUST00000128483.8 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rad50/SbcC_AAA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rad50_eukaryotes UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Zn_hook_RAD50 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:19360 UniProtKB/TrEMBL
MGD MGI:109292 ENTREZGENE
NCBI Gene 19360 ENTREZGENE
PANTHER DNA REPAIR PROTEIN RAD50 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RAD50 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam AAA_23 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rad50_zn_hook UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SbcC_Walker_B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Rad50 PhenoGen
PROSITE ZN_HOOK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Rad50 coiled-coil Zn hook UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A8Y5I3_MOUSE UniProtKB/TrEMBL
  E9PUJ2_MOUSE UniProtKB/TrEMBL
  P70388 ENTREZGENE
  Q3UNL2_MOUSE UniProtKB/TrEMBL
  Q3V0R5_MOUSE UniProtKB/TrEMBL
  Q5SV02 ENTREZGENE, UniProtKB/TrEMBL
  Q6PEB0 ENTREZGENE
  Q8C2T7 ENTREZGENE
  Q99M38_MOUSE UniProtKB/TrEMBL
  Q9CU59 ENTREZGENE
  RAD50_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q6PEB0 UniProtKB/Swiss-Prot
  Q8C2T7 UniProtKB/Swiss-Prot
  Q9CU59 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-29 Rad50  RAD50 double strand break repair protein    RAD50 homolog (S. cerevisiae)  Symbol and/or name change 5135510 APPROVED