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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:hydroxycoumarin
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Accession:CHEBI:37912 term browser browse the term
Definition:Any coumarin carrying at least one hydroxy substituent.
Synonyms:related_synonym: hydroxycoumarins
 alt_id: CHEBI:24691;   CHEBI:24692


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4-hydroxy-3-(2-hydroxy-3-oxo-1-phenylbutyl)-2H-chromen-2-one term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2c65 cytochrome P450, family 2, subfamily c, polypeptide 65 multiple interactions ISO 10-hydroxywarfarin binds to and results in decreased activity of CYP2C9 protein; 10-hydroxywarfarin inhibits the reaction [[CYP2C9 protein results in increased hydroxylation of Warfarin] which results in increased chemical synthesis of 7-hydroxywarfarin]; [10-hydroxywarfarin binds to and results in increased activity of NR1I2 protein] which results in increased expression of CYP2C9 mRNA; [CYP2C9 gene polymorphism affects the metabolism of Warfarin] which affects the abundance of 10-hydroxywarfarin CTD PMID:20429590 PMID:20735727 PMID:27539372 NCBI chr19:39,049,450...39,082,392
Ensembl chr19:39,049,459...39,082,388 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO 10-hydroxywarfarin binds to and results in increased activity of NR1I2 protein; [10-hydroxywarfarin binds to and results in increased activity of NR1I2 protein] which results in increased expression of CYP2C9 mRNA; [10-hydroxywarfarin binds to and results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA CTD PMID:20735727 NCBI chr16:38,068,711...38,115,211
Ensembl chr16:38,068,685...38,115,186 		JBrowse link
G Ugt2b34 UDP glucuronosyltransferase 2 family, polypeptide B34 multiple interactions ISO 10-hydroxywarfarin binds to and results in decreased activity of UGT2B7 protein; 10-hydroxywarfarin inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Zidovudine]; [10-hydroxywarfarin binds to and results in decreased activity of UGT2B7 protein] which results in decreased glucuronidation of Zidovudine CTD PMID:25393417 NCBI chr 5:87,037,613...87,054,805
Ensembl chr 5:87,037,626...87,054,796 		JBrowse link
4-hydroxy-3-[1-(4-hydroxyphenyl)-3-oxobutyl]-2H-chromen-2-one term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2c65 cytochrome P450, family 2, subfamily c, polypeptide 65 multiple interactions ISO 4'-hydroxywarfarin binds to and results in decreased activity of CYP2C9 protein; 4'-hydroxywarfarin inhibits the reaction [[CYP2C9 protein results in increased hydroxylation of Warfarin] which results in increased chemical synthesis of 7-hydroxywarfarin]; [4'-hydroxywarfarin binds to and results in increased activity of NR1I2 protein] which results in increased expression of CYP2C9 mRNA; [CYP2C9 gene polymorphism affects the metabolism of Warfarin] which affects the abundance of 4'-hydroxywarfarin CTD PMID:20429590 PMID:20735727 PMID:27539372 NCBI chr19:39,049,450...39,082,392
Ensembl chr19:39,049,459...39,082,388 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO 4'-hydroxywarfarin binds to and results in increased activity of NR1I2 protein; [4'-hydroxywarfarin binds to and results in increased activity of NR1I2 protein] which results in increased expression of CYP2C9 mRNA; [4'-hydroxywarfarin binds to and results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA CTD PMID:20735727 NCBI chr16:38,068,711...38,115,211
Ensembl chr16:38,068,685...38,115,186 		JBrowse link
G Ugt2b34 UDP glucuronosyltransferase 2 family, polypeptide B34 multiple interactions ISO 4'-hydroxywarfarin binds to and results in decreased activity of UGT2B7 protein; 4'-hydroxywarfarin inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Zidovudine]; [4'-hydroxywarfarin binds to and results in decreased activity of UGT2B7 protein] which results in decreased glucuronidation of Zidovudine CTD PMID:25393417 NCBI chr 5:87,037,613...87,054,805
Ensembl chr 5:87,037,626...87,054,796 		JBrowse link
4-hydroxycoumarin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrm1 adhesion regulating molecule 1 26S proteasome ubiquitin receptor decreases expression EXP 4-hydroxycoumarin results in decreased expression of ADRM1 mRNA CTD PMID:18492274 NCBI chr 2:179,813,381...179,818,076
Ensembl chr 2:179,813,278...179,818,079 		JBrowse link
G Glo1 glyoxalase 1 decreases activity ISO 4-hydroxycoumarin analog results in decreased activity of GLO1 protein CTD PMID:33989593 NCBI chr17:30,811,835...30,831,633
Ensembl chr17:30,803,910...30,845,845 		JBrowse link
G Ptk2 PTK2 protein tyrosine kinase 2 decreases phosphorylation EXP 4-hydroxycoumarin results in decreased phosphorylation of PTK2 protein CTD PMID:18492274 NCBI chr15:73,076,951...73,297,192
Ensembl chr15:73,076,951...73,295,129 		JBrowse link
G Pxn paxillin decreases expression
decreases phosphorylation
affects localization		 EXP 4-hydroxycoumarin results in decreased expression of PXN mRNA alternative form; 4-hydroxycoumarin results in decreased expression of PXN protein alternative form
4-hydroxycoumarin results in decreased phosphorylation of PXN protein
4-hydroxycoumarin affects the localization of PXN protein		 CTD PMID:18492274 NCBI chr 5:115,630,035...115,694,046
Ensembl chr 5:115,644,735...115,694,046 		JBrowse link
G Rac1 Rac family small GTPase 1 decreases expression EXP 4-hydroxycoumarin results in decreased expression of RAC1 protein CTD PMID:18492274 NCBI chr 5:143,491,236...143,513,786
Ensembl chr 5:143,489,389...143,513,791 		JBrowse link
G Ugt1a6b UDP glucuronosyltransferase 1 family, polypeptide A6B affects metabolic processing
increases metabolic processing		 ISO UGT1A6 gene polymorphism affects the metabolism of 4-hydroxycoumarin
UGT1A6 protein results in increased metabolism of 4-hydroxycoumarin		 CTD PMID:9429234 NCBI chr 1:88,030,979...88,146,720
Ensembl chr 1:88,030,974...88,146,725 		JBrowse link
G Vkorc1 vitamin K epoxide reductase complex, subunit 1 decreases activity
multiple interactions		 ISO 4-hydroxycoumarin results in decreased activity of VKORC1 protein
4-hydroxycoumarin inhibits the reaction [VKORC1 protein results in increased reduction of Vitamin K 1]		 CTD PMID:29581108 NCBI chr 7:127,492,235...127,494,833
Ensembl chr 7:127,485,399...127,494,626
Ensembl chr 7:127,485,399...127,494,626 		JBrowse link
G Vkorc1l1 vitamin K epoxide reductase complex, subunit 1-like 1 multiple interactions
decreases activity		 ISO 4-hydroxycoumarin inhibits the reaction [VKORC1L1 protein results in increased reduction of Vitamin K 1]
4-hydroxycoumarin results in decreased activity of VKORC1L1 protein		 CTD PMID:29581108 NCBI chr 5:129,970,950...130,015,533
Ensembl chr 5:129,970,811...130,015,533 		JBrowse link
4-methylumbelliferone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg2 ATP binding cassette subfamily G member 2 (Junior blood group) affects export EXP ABCG2 protein affects the export of Hymecromone analog CTD PMID:15598971 NCBI chr 6:58,561,476...58,669,436
Ensembl chr 6:58,561,508...58,672,661 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions EXP Hymecromone inhibits the reaction [Dietary Fats results in decreased expression of ADIPOQ protein] CTD PMID:24661945 NCBI chr16:22,965,286...22,976,718
Ensembl chr16:22,965,286...22,976,778 		JBrowse link
G Cat catalase multiple interactions EXP Hymecromone inhibits the reaction [Dietary Fats results in decreased activity of CAT protein] CTD PMID:24661945 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions EXP Hymecromone inhibits the reaction [Dietary Fats results in increased activity of CYP2E1 protein] CTD PMID:24661945 NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900 		JBrowse link
G Sult5a1 sulfotransferase family 5A, member 1 increases sulfation EXP SULT1A1 protein results in increased sulfation of Hymecromone CTD PMID:11181495 NCBI chr 8:123,869,582...123,885,170
Ensembl chr 8:123,866,931...123,885,054 		JBrowse link
G Trp53 transformation related protein 53 affects activity ISO Hymecromone affects the activity of TP53 protein; Hymecromone metabolite affects the activity of TP53 protein CTD PMID:35435491 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase 1 family, polypeptide A1 multiple interactions
increases metabolic processing
increases activity
increases glucuronidation		 ISO [UGT1A1 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; [UGT1A1 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; belinostat inhibits the reaction [[UGT1A1 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; belinostat inhibits the reaction [UGT1A1 protein results in increased glucuronidation of Hymecromone]; Diclofenac inhibits the reaction [[UGT1A1 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; Diclofenac inhibits the reaction [UGT1A1 protein results in increased glucuronidation of Hymecromone]; Estradiol promotes the reaction [UGT1A1 protein results in increased glucuronidation of Hymecromone]; licochalcone A inhibits the reaction [Hymecromone results in increased activity of UGT1A1 protein]; osimertinib inhibits the reaction [UGT1A1 protein results in increased glucuronidation of Hymecromone]; pterostilbene inhibits the reaction [[UGT1A1 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide] CTD PMID:15378558 PMID:15593333 PMID:15802387 PMID:26875642 PMID:31812603 More... NCBI chr 1:88,139,681...88,147,724
Ensembl chr 1:88,139,681...88,146,719 		JBrowse link
G Ugt1a10 UDP glycosyltransferase 1 family, polypeptide A10 increases glucuronidation
increases activity
multiple interactions		 ISO UGT1A10 protein results in increased glucuronidation of Hymecromone
Hymecromone results in increased activity of UGT1A10 protein
[UGT1A10 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; licochalcone A inhibits the reaction [Hymecromone results in increased activity of UGT1A10 protein]		 CTD PMID:15802387 PMID:22265884 PMID:25393417 PMID:26875642 PMID:33290829 NCBI chr 1:87,983,133...88,147,724
Ensembl chr 1:87,983,110...88,146,726 		JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases metabolic processing
multiple interactions
increases glucuronidation
increases activity		 ISO UGT1A3 protein results in increased metabolism of Hymecromone
[UGT1A3 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; [UGT1A3 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; Androsterone inhibits the reaction [[UGT1A3 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; Androsterone inhibits the reaction [UGT1A3 protein results in increased glucuronidation of Hymecromone]; belinostat inhibits the reaction [[UGT1A3 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; belinostat inhibits the reaction [UGT1A3 protein results in increased glucuronidation of Hymecromone]; licochalcone A inhibits the reaction [Hymecromone results in increased activity of UGT1A3 protein]; pterostilbene inhibits the reaction [[UGT1A3 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]		 CTD PMID:15802387 PMID:26875642 PMID:31812603 PMID:33290829 NCBI chr 1:88,128,333...88,147,724
Ensembl chr 1:88,128,323...88,146,719 		JBrowse link
G Ugt1a6a UDP glucuronosyltransferase 1 family, polypeptide A6A increases glucuronidation EXP UGT1A6A protein results in increased glucuronidation of Hymecromone CTD PMID:8068691 NCBI chr 1:88,062,531...88,147,724
Ensembl chr 1:88,062,531...88,146,719 		JBrowse link
G Ugt1a6b UDP glucuronosyltransferase 1 family, polypeptide A6B multiple interactions
increases metabolic processing
increases activity
affects metabolic processing
increases glucuronidation		 ISO [UGT1A6 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; [UGT1A6 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; belinostat inhibits the reaction [[UGT1A6 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; belinostat inhibits the reaction [UGT1A6 protein results in increased glucuronidation of Hymecromone]; bisphenol A inhibits the reaction [UGT1A6 protein results in increased glucuronidation of Hymecromone]; Diclofenac inhibits the reaction [[UGT1A6 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; Diclofenac inhibits the reaction [UGT1A6 protein results in increased glucuronidation of Hymecromone]; licochalcone A inhibits the reaction [Hymecromone results in increased activity of UGT1A6 protein]; pterostilbene inhibits the reaction [[UGT1A6 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]
UGT1A6 gene polymorphism affects the metabolism of Hymecromone		 CTD PMID:9429234 PMID:15802387 PMID:18214896 PMID:25393417 PMID:26875642 More... NCBI chr 1:88,030,979...88,146,720
Ensembl chr 1:88,030,974...88,146,725 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase 1 family, polypeptide A9 increases glucuronidation
increases metabolic processing
increases activity
multiple interactions		 ISO UGT1A9 protein results in increased glucuronidation of Hymecromone
UGT1A9 protein results in increased metabolism of Hymecromone
Hymecromone results in increased activity of UGT1A9 protein
[UGT1A9 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; [UGT1A9 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; Diclofenac inhibits the reaction [[UGT1A9 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; Diclofenac inhibits the reaction [UGT1A9 protein results in increased glucuronidation of Hymecromone]; licochalcone A inhibits the reaction [Hymecromone results in increased activity of UGT1A9 protein]; pterostilbene inhibits the reaction [[UGT1A9 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]		 CTD PMID:15378558 PMID:15802387 PMID:26875642 PMID:31812603 PMID:33290829 NCBI chr 1:87,998,501...88,147,724
Ensembl chr 1:87,998,522...88,146,719 		JBrowse link
G Ugt2a1 UDP glucuronosyltransferase 2 family, polypeptide A1 increases glucuronidation ISO UGT2A1 protein results in increased glucuronidation of Hymecromone CTD PMID:21164388 NCBI chr 5:87,607,349...87,638,730
Ensembl chr 5:87,607,349...87,638,730 		JBrowse link
G Ugt2b1 UDP glucuronosyltransferase 2 family, polypeptide B1 increases glucuronidation
increases activity
multiple interactions
increases metabolic processing		 ISO UGT2B1 protein results in increased glucuronidation of Hymecromone
UGT2B17 protein results in increased glucuronidation of Hymecromone
Hymecromone results in increased activity of UGT2B17 protein
[UGT2B17 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; licochalcone A inhibits the reaction [Hymecromone results in increased activity of UGT2B17 protein]
UGT2B17 protein results in increased metabolism of Hymecromone		 CTD PMID:8302279 PMID:8798464 PMID:26875642 PMID:33290829 NCBI chr 5:87,064,498...87,074,362
Ensembl chr 5:87,064,497...87,074,389 		JBrowse link
G Ugt2b34 UDP glucuronosyltransferase 2 family, polypeptide B34 multiple interactions
increases glucuronidation
increases metabolic processing
increases activity		 ISO [UGT2B7 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; [UGT2B7 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; Androsterone inhibits the reaction [[UGT2B7 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; Androsterone inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Hymecromone]; belinostat inhibits the reaction [[UGT2B7 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; belinostat inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Hymecromone]; licochalcone A inhibits the reaction [Hymecromone results in increased activity of UGT2B7 protein]; pterostilbene inhibits the reaction [[UGT2B7 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide] CTD PMID:26875642 PMID:31812603 PMID:33290829 NCBI chr 5:87,037,613...87,054,805
Ensembl chr 5:87,037,626...87,054,796 		JBrowse link
4-methylumbelliferone beta-D-glucuronide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ugt1a1 UDP glucuronosyltransferase 1 family, polypeptide A1 multiple interactions ISO [UGT1A1 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; [UGT1A1 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; belinostat inhibits the reaction [[UGT1A1 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; Diclofenac inhibits the reaction [[UGT1A1 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; pterostilbene inhibits the reaction [[UGT1A1 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide] CTD PMID:31812603 PMID:33290829 NCBI chr 1:88,139,681...88,147,724
Ensembl chr 1:88,139,681...88,146,719 		JBrowse link
G Ugt1a10 UDP glycosyltransferase 1 family, polypeptide A10 multiple interactions ISO [UGT1A10 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide CTD PMID:33290829 NCBI chr 1:87,983,133...88,147,724
Ensembl chr 1:87,983,110...88,146,726 		JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 multiple interactions ISO [UGT1A3 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; [UGT1A3 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; Androsterone inhibits the reaction [[UGT1A3 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; belinostat inhibits the reaction [[UGT1A3 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; pterostilbene inhibits the reaction [[UGT1A3 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide] CTD PMID:31812603 PMID:33290829 NCBI chr 1:88,128,333...88,147,724
Ensembl chr 1:88,128,323...88,146,719 		JBrowse link
G Ugt1a6b UDP glucuronosyltransferase 1 family, polypeptide A6B multiple interactions ISO [UGT1A6 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; [UGT1A6 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; belinostat inhibits the reaction [[UGT1A6 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; Diclofenac inhibits the reaction [[UGT1A6 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; pterostilbene inhibits the reaction [[UGT1A6 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide] CTD PMID:31812603 PMID:33290829 NCBI chr 1:88,030,979...88,146,720
Ensembl chr 1:88,030,974...88,146,725 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase 1 family, polypeptide A9 multiple interactions ISO [UGT1A9 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; [UGT1A9 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; Diclofenac inhibits the reaction [[UGT1A9 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; pterostilbene inhibits the reaction [[UGT1A9 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide] CTD PMID:31812603 PMID:33290829 NCBI chr 1:87,998,501...88,147,724
Ensembl chr 1:87,998,522...88,146,719 		JBrowse link
G Ugt2b1 UDP glucuronosyltransferase 2 family, polypeptide B1 multiple interactions ISO [UGT2B17 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide CTD PMID:33290829 NCBI chr 5:87,064,498...87,074,362
Ensembl chr 5:87,064,497...87,074,389 		JBrowse link
G Ugt2b34 UDP glucuronosyltransferase 2 family, polypeptide B34 multiple interactions ISO [UGT2B7 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; [UGT2B7 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; Androsterone inhibits the reaction [[UGT2B7 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; belinostat inhibits the reaction [[UGT2B7 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; pterostilbene inhibits the reaction [[UGT2B7 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide] CTD PMID:31812603 PMID:33290829 NCBI chr 5:87,037,613...87,054,805
Ensembl chr 5:87,037,626...87,054,796 		JBrowse link
4-methylumbelliferone sulfate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc22a19 solute carrier family 22 (organic anion transporter), member 19 multiple interactions ISO 4-methylumbelliferyl sulfate inhibits the reaction [SLC22A19 protein affects the transport of estrone sulfate]; 4-methylumbelliferyl sulfate inhibits the reaction [SLC22A9 protein affects the transport of estrone sulfate] CTD PMID:16079298 PMID:18441515 NCBI chr19:7,650,440...7,688,675
Ensembl chr19:7,650,426...7,688,675 		JBrowse link
4-methylumbelliferyl acetate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Calr calreticulin increases activity ISO 4-methylumbelliferyl acetate results in increased activity of CALR protein CTD PMID:20188080 NCBI chr 8:85,568,717...85,573,560
Ensembl chr 8:85,568,479...85,573,563 		JBrowse link
G Ces1d carboxylesterase 1D increases hydrolysis
multiple interactions		 ISO CES1 protein results in increased hydrolysis of 4-methylumbelliferyl acetate
Atropine inhibits the reaction [CES1 protein results in increased hydrolysis of 4-methylumbelliferyl acetate]; Cocaine inhibits the reaction [CES1 protein results in increased hydrolysis of 4-methylumbelliferyl acetate]; tropacocaine inhibits the reaction [CES1 protein results in increased hydrolysis of 4-methylumbelliferyl acetate]		 CTD PMID:9311626 NCBI chr 8:93,892,700...93,924,432
Ensembl chr 8:93,892,696...93,924,466 		JBrowse link
G Ces2h carboxylesterase 2H increases hydrolysis ISO CES2 protein results in increased hydrolysis of 4-methylumbelliferyl acetate CTD PMID:9169443 NCBI chr 8:105,727,462...105,747,042
Ensembl chr 8:105,727,485...105,747,810 		JBrowse link
G Txn1 thioredoxin 1 increases activity ISO 4-methylumbelliferyl acetate results in increased activity of TXN protein CTD PMID:24103856 NCBI chr 4:57,943,373...57,956,411
Ensembl chr 4:57,943,373...57,956,411 		JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO 4-methylumbelliferyl acetate results in increased expression of VEGFA protein CTD PMID:24103856 NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295 		JBrowse link
4-methylumbelliferyl beta-D-galactoside term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Car12 carbonic anhydrase 12 decreases activity ISO 4-methylumbelliferyl-galactopyranoside analog results in decreased activity of CA12 protein CTD PMID:22077347 NCBI chr 9:66,619,026...66,674,127
Ensembl chr 9:66,620,968...66,674,127 		JBrowse link
G Car9 carbonic anhydrase 9 decreases activity ISO 4-methylumbelliferyl-galactopyranoside analog results in decreased activity of CA9 protein CTD PMID:22077347 NCBI chr 4:43,507,026...43,513,729
Ensembl chr 4:43,506,966...43,513,729 		JBrowse link
4-methylumbelliferyl beta-D-glucoside term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gaa glucosidase, alpha, acid multiple interactions
increases metabolic processing		 ISO GAA gene SNP inhibits the reaction [GAA protein results in increased metabolism of 4-methylumbelliferyl glucoside] CTD PMID:21963784 NCBI chr11:119,158,789...119,176,284
Ensembl chr11:119,158,713...119,176,280 		JBrowse link
7,8-diacetoxy-4-methylcoumarin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2l1 BCL2-like 1 decreases expression ISO 7,8-diacetoxy-4-methylcoumarin results in decreased expression of BCL2L1 protein CTD PMID:19061872 NCBI chr 2:152,600,652...152,673,632
Ensembl chr 2:152,622,588...152,673,648 		JBrowse link
G Calr calreticulin multiple interactions
increases activity		 ISO 7,8-diacetoxy-4-methylcoumarin promotes the reaction [CALR protein results in increased acetylation of NOS1 protein]
7,8-diacetoxy-4-methylcoumarin results in increased activity of CALR protein		 CTD PMID:20188080 PMID:24103856 NCBI chr 8:85,568,717...85,573,560
Ensembl chr 8:85,568,479...85,573,563 		JBrowse link
G Casp3 caspase 3 increases activity ISO 7,8-diacetoxy-4-methylcoumarin results in increased activity of CASP3 protein CTD PMID:19061872 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Casp9 caspase 9 increases activity ISO 7,8-diacetoxy-4-methylcoumarin results in increased activity of CASP9 protein CTD PMID:19061872 NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287 		JBrowse link
G Cycs cytochrome c, somatic affects localization ISO 7,8-diacetoxy-4-methylcoumarin affects the localization of CYCS protein CTD PMID:19061872 NCBI chr 6:50,539,543...50,543,549
Ensembl chr 6:50,539,543...50,543,518 		JBrowse link
G Nos1 nitric oxide synthase 1, neuronal multiple interactions ISO 7,8-diacetoxy-4-methylcoumarin promotes the reaction [CALR protein results in increased acetylation of NOS1 protein] CTD PMID:24103856 NCBI chr 5:118,004,904...118,096,905
Ensembl chr 5:117,919,097...118,096,905 		JBrowse link
G Nos2 nitric oxide synthase 2, inducible increases expression ISO 7,8-diacetoxy-4-methylcoumarin results in increased expression of NOS2 CTD PMID:24103856 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080 		JBrowse link
G Nos3 nitric oxide synthase 3, endothelial cell increases expression ISO 7,8-diacetoxy-4-methylcoumarin results in increased expression of NOS3 CTD PMID:24103856 NCBI chr 5:24,569,772...24,589,472
Ensembl chr 5:24,569,808...24,589,472 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO 7,8-diacetoxy-4-methylcoumarin results in decreased expression of PTGS2 protein CTD PMID:19061872 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978 		JBrowse link
G Rac1 Rac family small GTPase 1 decreases expression ISO DAMTC decreases expression of RAC1 protein in non-small cell lung cancer cells RGD PMID:23059821 RGD:155791641 NCBI chr 5:143,491,236...143,513,786
Ensembl chr 5:143,489,389...143,513,791 		JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions ISO 7,8-diacetoxy-4-methylcoumarin inhibits the reaction [TNF protein affects the localization of RELA protein] CTD PMID:19061872 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO 7,8-diacetoxy-4-methylcoumarin inhibits the reaction [TNF protein affects the localization of RELA protein] CTD PMID:19061872 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Trp53 transformation related protein 53 increases expression ISO 7,8-diacetoxy-4-methylcoumarin results in increased expression of TP53 protein CTD PMID:19061872 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699 		JBrowse link
G Txn1 thioredoxin 1 increases expression
increases activity		 ISO 7,8-diacetoxy-4-methylcoumarin results in increased expression of TXN mRNA
7,8-diacetoxy-4-methylcoumarin results in increased activity of TXN protein		 CTD PMID:24103856 NCBI chr 4:57,943,373...57,956,411
Ensembl chr 4:57,943,373...57,956,411 		JBrowse link
G Txnip thioredoxin interacting protein decreases expression ISO 7,8-diacetoxy-4-methylcoumarin results in decreased expression of TXNIP mRNA CTD PMID:24103856 NCBI chr 3:96,465,273...96,469,173
Ensembl chr 3:96,465,273...96,469,199 		JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO 7,8-diacetoxy-4-methylcoumarin results in increased expression of TXNRD1 mRNA CTD PMID:24103856 NCBI chr10:82,669,785...82,733,558
Ensembl chr10:82,669,785...82,733,546 		JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO 7,8-diacetoxy-4-methylcoumarin results in increased expression of VEGFA mRNA; 7,8-diacetoxy-4-methylcoumarin results in increased expression of VEGFA protein CTD PMID:24103856 NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295 		JBrowse link
7,8-dihydroxycoumarin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin multiple interactions ISO daphnetin inhibits the reaction [Benzene results in decreased expression of ALB protein] CTD PMID:33749080 NCBI chr 5:90,608,729...90,624,461
Ensembl chr 5:90,608,756...90,624,461 		JBrowse link
G Bax BCL2-associated X protein multiple interactions ISO
EXP		 alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [daphnetin inhibits the reaction [Lipopolysaccharides results in increased expression of BAX protein]]; daphnetin inhibits the reaction [Lipopolysaccharides results in increased expression of BAX protein]; daphnetin inhibits the reaction [sodium arsenite results in increased expression of BAX protein]; REG3A protein inhibits the reaction [daphnetin inhibits the reaction [Lipopolysaccharides results in increased expression of BAX protein]]
daphnetin inhibits the reaction [Dextran Sulfate results in increased expression of BAX protein]		 CTD PMID:30738023 PMID:37209277 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions ISO
EXP		 alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide promotes the reaction [daphnetin inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]]; daphnetin inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]; daphnetin inhibits the reaction [sodium arsenite results in decreased expression of BCL2 protein]; REG3A protein inhibits the reaction [daphnetin inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]]
daphnetin inhibits the reaction [Dextran Sulfate results in decreased expression of BCL2 protein]		 CTD PMID:30738023 PMID:37209277 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO
EXP		 alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide promotes the reaction [daphnetin inhibits the reaction [Lipopolysaccharides results in increased cleavage of CASP3 protein]]; daphnetin inhibits the reaction [Lipopolysaccharides results in increased cleavage of CASP3 protein]; REG3A protein inhibits the reaction [daphnetin inhibits the reaction [Lipopolysaccharides results in increased cleavage of CASP3 protein]]
daphnetin inhibits the reaction [Dextran Sulfate results in increased cleavage of CASP3 protein]		 CTD PMID:37209277 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO daphnetin inhibits the reaction [Benzene results in increased expression of CYP2E1 mRNA] CTD PMID:33749080 NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO daphnetin results in increased expression of GCLC protein CTD PMID:30738023 NCBI chr 9:77,661,817...77,701,771
Ensembl chr 9:77,661,817...77,701,767 		JBrowse link
G Gclm glutamate-cysteine ligase, modifier subunit increases expression ISO daphnetin results in increased expression of GCLM protein CTD PMID:30738023 NCBI chr 3:122,039,206...122,060,864
Ensembl chr 3:122,039,206...122,064,381 		JBrowse link
G Gpt glutamic pyruvic transaminase, soluble multiple interactions ISO daphnetin inhibits the reaction [Benzene results in increased expression of GPT protein] CTD PMID:33749080 NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions		 ISO daphnetin results in increased expression of HMOX1 protein
[sodium arsenite co-treated with daphnetin] results in increased expression of HMOX1 protein; NFE2L2 protein affects the reaction [daphnetin results in increased expression of HMOX1 protein]		 CTD PMID:30738023 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP		 daphnetin inhibits the reaction [Benzene results in increased expression of IL1B protein]
daphnetin inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein]
alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide promotes the reaction [daphnetin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]]; daphnetin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]; REG3A protein inhibits the reaction [daphnetin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]]		 CTD PMID:33749080 PMID:37209277 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il2 interleukin 2 multiple interactions ISO daphnetin inhibits the reaction [Benzene results in increased expression of IL2 protein] CTD PMID:33749080 NCBI chr 3:37,174,862...37,180,103
Ensembl chr 3:37,174,672...37,180,108 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP		 daphnetin inhibits the reaction [Benzene results in increased expression of IL6 protein]
alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide promotes the reaction [daphnetin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]]; daphnetin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; REG3A protein inhibits the reaction [daphnetin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]]
daphnetin inhibits the reaction [Dextran Sulfate results in increased expression of IL6 protein]		 CTD PMID:33749080 PMID:37209277 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Jak2 Janus kinase 2 multiple interactions ISO alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide promotes the reaction [daphnetin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of JAK2 protein]]; daphnetin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of JAK2 protein]; REG3A protein inhibits the reaction [daphnetin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of JAK2 protein]] CTD PMID:37209277 NCBI chr19:29,229,006...29,290,495
Ensembl chr19:29,229,228...29,290,480 		JBrowse link
G Keap1 kelch-like ECH-associated protein 1 decreases expression ISO daphnetin results in decreased expression of KEAP1 protein CTD PMID:30738023 NCBI chr 9:21,141,026...21,150,628
Ensembl chr 9:21,141,026...21,150,657 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 increases phosphorylation ISO daphnetin results in increased phosphorylation of MAPK1 protein CTD PMID:30738023 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 increases phosphorylation ISO daphnetin results in increased phosphorylation of MAPK3 protein CTD PMID:30738023 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991 		JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 multiple interactions ISO [sodium arsenite co-treated with daphnetin] results in increased expression of NFE2L2 protein; daphnetin results in increased expression of and affects the localization of NFE2L2 protein; NFE2L2 protein affects the reaction [daphnetin results in increased expression of HMOX1 protein] CTD PMID:30738023 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985 		JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 increases expression ISO daphnetin results in increased expression of NQO1 protein CTD PMID:30738023 NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838 		JBrowse link
G Ocln occludin multiple interactions EXP daphnetin inhibits the reaction [Dextran Sulfate results in decreased expression of OCLN protein] CTD PMID:37209277 NCBI chr13:100,633,012...100,689,226
Ensembl chr13:100,633,015...100,689,226 		JBrowse link
G Reg3b regenerating islet-derived 3 beta multiple interactions ISO daphnetin inhibits the reaction [Lipopolysaccharides results in increased expression of REG3A protein]; REG3A protein inhibits the reaction [daphnetin inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]]; REG3A protein inhibits the reaction [daphnetin inhibits the reaction [Lipopolysaccharides results in increased cleavage of CASP3 protein]]; REG3A protein inhibits the reaction [daphnetin inhibits the reaction [Lipopolysaccharides results in increased expression of BAX protein]]; REG3A protein inhibits the reaction [daphnetin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of JAK2 protein]]; REG3A protein inhibits the reaction [daphnetin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT3 protein]]; REG3A protein inhibits the reaction [daphnetin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]]; REG3A protein inhibits the reaction [daphnetin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]]; REG3A protein inhibits the reaction [daphnetin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]] CTD PMID:37209277 NCBI chr 6:78,347,868...78,350,449
Ensembl chr 6:78,347,640...78,350,449 		JBrowse link
G S1pr1 sphingosine-1-phosphate receptor 1 multiple interactions ISO daphnetin inhibits the reaction [Benzene results in increased expression of S1PR1 mRNA] CTD PMID:33749080 NCBI chr 3:115,504,082...115,508,704
Ensembl chr 3:115,504,082...115,508,721 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide promotes the reaction [daphnetin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT3 protein]]; daphnetin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT3 protein]; REG3A protein inhibits the reaction [daphnetin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT3 protein]] CTD PMID:37209277 NCBI chr11:100,777,632...100,830,447
Ensembl chr11:100,775,924...100,830,366 		JBrowse link
G Tjp1 tight junction protein 1 multiple interactions EXP daphnetin inhibits the reaction [Dextran Sulfate results in decreased expression of TJP1 protein] CTD PMID:37209277 NCBI chr 7:64,945,913...65,177,629
Ensembl chr 7:64,945,913...65,177,529 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP		 daphnetin inhibits the reaction [Benzene results in increased expression of TNF protein]
daphnetin inhibits the reaction [Dextran Sulfate results in increased expression of TNF protein]
alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide promotes the reaction [daphnetin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; daphnetin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; REG3A protein inhibits the reaction [daphnetin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]		 CTD PMID:33749080 PMID:37209277 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
7-ethoxycoumarin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases metabolic processing ISO CYP2E1 protein results in increased metabolism of 7-ethoxycoumarin CTD PMID:18385292 NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900 		JBrowse link
7-Hydroxywarfarin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2c65 cytochrome P450, family 2, subfamily c, polypeptide 65 affects abundance
multiple interactions
increases chemical synthesis
decreases activity		 ISO CYP2C9 gene polymorphism affects the abundance of 7-hydroxywarfarin
10-hydroxywarfarin inhibits the reaction [[CYP2C9 protein results in increased hydroxylation of Warfarin] which results in increased chemical synthesis of 7-hydroxywarfarin]; 4'-hydroxywarfarin inhibits the reaction [[CYP2C9 protein results in increased hydroxylation of Warfarin] which results in increased chemical synthesis of 7-hydroxywarfarin]; 6-hydroxywarfarin inhibits the reaction [[CYP2C9 protein results in increased hydroxylation of Warfarin] which results in increased chemical synthesis of 7-hydroxywarfarin]; 7-hydroxywarfarin inhibits the reaction [[CYP2C9 protein results in increased hydroxylation of Warfarin] which results in increased chemical synthesis of 6-hydroxywarfarin]; 8-hydroxywarfarin inhibits the reaction [[CYP2C9 protein results in increased hydroxylation of Warfarin] which results in increased chemical synthesis of 7-hydroxywarfarin]; [[Ticrynafen results in decreased activity of CYP2C9 protein] which affects the metabolism of Warfarin analog] which affects the abundance of 7-hydroxywarfarin; [CYP2C9 gene polymorphism affects the metabolism of Warfarin] which affects the abundance of 7-hydroxywarfarin; [CYP2C9 protein results in increased hydroxylation of Warfarin] which results in increased chemical synthesis of 7-hydroxywarfarin; [CYP2C9 protein results in increased metabolism of Warfarin] which results in increased chemical synthesis of 7-hydroxywarfarin
CYP2C9 protein results in increased chemical synthesis of 7-hydroxywarfarin
7-hydroxywarfarin results in decreased activity of CYP2C9 protein		 CTD PMID:19408964 PMID:20429590 PMID:25986145 PMID:27539372 PMID:31854189 NCBI chr19:39,049,450...39,082,392
Ensembl chr19:39,049,459...39,082,388 		JBrowse link
G Ugt2b34 UDP glucuronosyltransferase 2 family, polypeptide B34 multiple interactions ISO 7-hydroxywarfarin binds to and results in decreased activity of UGT2B7 protein; 7-hydroxywarfarin inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Zidovudine]; [7-hydroxywarfarin binds to and results in decreased activity of UGT2B7 protein] which results in decreased glucuronidation of Zidovudine CTD PMID:25393417 NCBI chr 5:87,037,613...87,054,805
Ensembl chr 5:87,037,626...87,054,796 		JBrowse link
G Vkorc1 vitamin K epoxide reductase complex, subunit 1 affects abundance ISO VKORC1 gene polymorphism affects the abundance of 7-hydroxywarfarin CTD PMID:25986145 NCBI chr 7:127,492,235...127,494,833
Ensembl chr 7:127,485,399...127,494,626
Ensembl chr 7:127,485,399...127,494,626 		JBrowse link
acenocoumarol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B member 1A affects response to substance ISO ABCB1 gene polymorphism affects the susceptibility to Acenocoumarol CTD PMID:18021343 NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575 		JBrowse link
G Apoe apolipoprotein E affects response to substance ISO APOE gene polymorphism affects the susceptibility to Acenocoumarol CTD PMID:15861030 NCBI chr 7:19,430,169...19,434,326
Ensembl chr 7:19,430,034...19,433,113 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 affects metabolic processing ISO CYP1A1 protein affects the metabolism of Acenocoumarol CTD PMID:11918509 NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 affects metabolic processing ISO CYP1A2 protein affects the metabolism of Acenocoumarol CTD PMID:11918509 NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986 		JBrowse link
G Cyp2c38 cytochrome P450, family 2, subfamily c, polypeptide 38 affects metabolic processing ISO CYP2C19 protein affects the metabolism of Acenocoumarol CTD PMID:11918509 NCBI chr19:39,379,109...39,451,519
Ensembl chr19:39,378,000...39,451,519 		JBrowse link
G Cyp2c52-ps cytochrome P450, family 2, subfamily c, polypeptide 52, pseudogene affects response to substance ISO CYP2C18 gene polymorphism affects the susceptibility to Acenocoumarol CTD PMID:19578179 NCBI chr19:38,965,106...38,992,071
Ensembl chr19:38,965,091...38,991,733 		JBrowse link
G Cyp2c65 cytochrome P450, family 2, subfamily c, polypeptide 65 increases metabolic processing
increases response to substance
affects response to substance
affects metabolic processing		 ISO CYP2C9 protein results in increased metabolism of Acenocoumarol
CYP2C9 protein results in increased susceptibility to Acenocoumarol
CYP2C9 gene polymorphism affects the susceptibility to Acenocoumarol; CYP2C9 gene SNP affects the susceptibility to Acenocoumarol
CYP2C9 protein affects the metabolism of Acenocoumarol		 CTD PMID:11918509 PMID:15213846 PMID:16869821 PMID:16878445 PMID:18021343 More... NCBI chr19:39,049,450...39,082,392
Ensembl chr19:39,049,459...39,082,388 		JBrowse link
G F10 coagulation factor X decreases activity ISO Acenocoumarol results in decreased activity of F10 protein CTD PMID:3490277 NCBI chr 8:13,087,308...13,106,676
Ensembl chr 8:13,087,308...13,106,676 		JBrowse link
G F2 coagulation factor II decreases activity ISO Acenocoumarol results in decreased activity of F2 protein CTD PMID:3490277 NCBI chr 2:91,442,742...91,466,799
Ensembl chr 2:91,455,665...91,466,759 		JBrowse link
G F5 coagulation factor V decreases activity ISO Acenocoumarol results in decreased activity of F5 protein CTD PMID:3490277 NCBI chr 1:163,979,396...164,048,539
Ensembl chr 1:163,979,407...164,047,846 		JBrowse link
G F7 coagulation factor VII decreases activity ISO Acenocoumarol results in decreased activity of F7 protein CTD PMID:3490277 NCBI chr 8:13,075,499...13,085,809
Ensembl chr 8:13,076,034...13,085,809 		JBrowse link
G F9 coagulation factor IX decreases activity ISO Acenocoumarol results in decreased activity of F9 protein CTD PMID:3490277 NCBI chr  X:59,044,675...59,076,120
Ensembl chr  X:59,044,824...59,076,119 		JBrowse link
G Ggcx gamma-glutamyl carboxylase increases activity ISO Acenocoumarol results in increased activity of GGCX protein CTD PMID:3490277 NCBI chr 6:72,391,262...72,407,696
Ensembl chr 6:72,391,291...72,407,695 		JBrowse link
G Vkorc1 vitamin K epoxide reductase complex, subunit 1 decreases response to substance
decreases activity
multiple interactions
affects response to substance
increases response to substance		 ISO VKORC1 promoter polymorphism results in decreased susceptibility to Acenocoumarol; VKORC1 protein polymorphism results in decreased susceptibility to Acenocoumarol
Acenocoumarol results in decreased activity of VKORC1 protein
Acenocoumarol inhibits the reaction [VKORC1 protein results in increased reduction of Vitamin K 1]
VKORC1 gene polymorphism affects the susceptibility to Acenocoumarol; VKORC1 gene SNP affects the susceptibility to Acenocoumarol; VKORC1 intron SNP affects the susceptibility to Acenocoumarol; VKORC1 polymorphism affects the susceptibility to Acenocoumarol; VKORC1 protein polymorphism affects the susceptibility to Acenocoumarol
VKORC1 protein results in increased susceptibility to Acenocoumarol		 CTD PMID:16201835 PMID:16611310 PMID:16869821 PMID:17036862 PMID:18698879 More... NCBI chr 7:127,492,235...127,494,833
Ensembl chr 7:127,485,399...127,494,626
Ensembl chr 7:127,485,399...127,494,626 		JBrowse link
G Vkorc1l1 vitamin K epoxide reductase complex, subunit 1-like 1 multiple interactions
decreases activity		 ISO Acenocoumarol inhibits the reaction [VKORC1L1 protein results in increased reduction of Vitamin K 1]
Acenocoumarol results in decreased activity of VKORC1L1 protein		 CTD PMID:29581108 NCBI chr 5:129,970,950...130,015,533
Ensembl chr 5:129,970,811...130,015,533 		JBrowse link
auraptene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B member 1A multiple interactions ISO aurapten promotes the reaction [ABCB1 protein results in increased hydrolysis of Adenosine Triphosphate]; aurapten promotes the reaction [ABCB1 protein results in increased import of Daunorubicin] CTD PMID:18955043 NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575 		JBrowse link
G Ccna2 cyclin A2 affects expression ISO aurapten affects the expression of CCNA2 mRNA CTD PMID:23320178 NCBI chr 3:36,619,014...36,627,187
Ensembl chr 3:36,619,014...36,626,299 		JBrowse link
G Ccnb2 cyclin B2 affects expression ISO aurapten affects the expression of CCNB2 mRNA CTD PMID:23320178 NCBI chr 9:70,314,971...70,328,836
Ensembl chr 9:70,314,974...70,328,829 		JBrowse link
G Cdc45 cell division cycle 45 affects expression ISO aurapten affects the expression of CDC45 mRNA CTD PMID:23320178 NCBI chr16:18,599,202...18,632,371
Ensembl chr16:18,599,197...18,630,737 		JBrowse link
G Cdk1 cyclin dependent kinase 1 affects expression ISO aurapten affects the expression of CDK1 mRNA CTD PMID:23320178 NCBI chr10:69,170,976...69,188,742
Ensembl chr10:69,170,976...69,188,768 		JBrowse link
G Cdkn2b cyclin dependent kinase inhibitor 2B affects expression ISO aurapten affects the expression of CDKN2B mRNA CTD PMID:23320178 NCBI chr 4:89,224,526...89,229,269
Ensembl chr 4:89,224,536...89,229,276 		JBrowse link
G Cdkn2c cyclin dependent kinase inhibitor 2C affects expression ISO aurapten affects the expression of CDKN2C mRNA CTD PMID:23320178 NCBI chr 4:109,518,073...109,523,953
Ensembl chr 4:109,518,073...109,524,386 		JBrowse link
G Chek1 checkpoint kinase 1 affects expression ISO aurapten affects the expression of CHEK1 mRNA CTD PMID:23320178 NCBI chr 9:36,619,935...36,637,897
Ensembl chr 9:36,619,778...36,638,361 		JBrowse link
G Chek2 checkpoint kinase 2 affects expression ISO aurapten affects the expression of CHEK2 mRNA CTD PMID:23320178 NCBI chr 5:110,987,668...111,022,006
Ensembl chr 5:110,987,845...111,022,011 		JBrowse link
G Ctnnb1 catenin beta 1 decreases expression ISO aurapten results in decreased expression of CTNNB1 protein mutant form CTD PMID:16012713 NCBI chr 9:120,762,466...120,789,573
Ensembl chr 9:120,758,282...120,789,573 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO aurapten inhibits the reaction [DDT results in increased expression of CYP1A1 mRNA]; aurapten inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] CTD PMID:20865247 NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 affects expression ISO aurapten affects the expression of DDIT3 mRNA CTD PMID:23320178 NCBI chr10:127,126,662...127,132,160
Ensembl chr10:127,126,643...127,132,157
Ensembl chr10:127,126,643...127,132,157 		JBrowse link
G Dusp1 dual specificity phosphatase 1 affects expression ISO aurapten affects the expression of DUSP1 mRNA CTD PMID:23320178 NCBI chr17:26,724,565...26,727,446
Ensembl chr17:26,724,564...26,781,102 		JBrowse link
G E2f1 E2F transcription factor 1 affects expression ISO aurapten affects the expression of E2F1 mRNA CTD PMID:23320178 NCBI chr 2:154,401,320...154,411,812
Ensembl chr 2:154,401,327...154,411,812 		JBrowse link
G E2f2 E2F transcription factor 2 affects expression ISO aurapten affects the expression of E2F2 mRNA CTD PMID:23320178 NCBI chr 4:135,899,585...135,923,368
Ensembl chr 4:135,899,705...135,923,368 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible 45 alpha affects expression ISO aurapten affects the expression of GADD45A mRNA CTD PMID:23320178 NCBI chr 6:67,012,080...67,014,391
Ensembl chr 6:67,012,080...67,014,441 		JBrowse link
G Jun jun proto-oncogene affects expression ISO aurapten affects the expression of JUN mRNA CTD PMID:23320178 NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459 		JBrowse link
G Kif20b kinesin family member 20B affects expression ISO aurapten affects the expression of KIF20B mRNA CTD PMID:23320178 NCBI chr19:34,899,735...34,953,150
Ensembl chr19:34,899,761...34,953,145 		JBrowse link
G Mcm3 minichromosome maintenance complex component 3 affects expression ISO aurapten affects the expression of MCM3 mRNA CTD PMID:23320178 NCBI chr 1:20,873,188...20,890,536
Ensembl chr 1:20,873,192...20,890,536 		JBrowse link
G Mcm6 minichromosome maintenance complex component 6 affects expression ISO aurapten affects the expression of MCM6 mRNA CTD PMID:23320178 NCBI chr 1:128,259,312...128,287,442
Ensembl chr 1:128,259,327...128,287,401 		JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 affects response to substance EXP NFE2L2 protein affects the susceptibility to aurapten CTD PMID:19150646 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO aurapten inhibits the reaction [DDT results in increased expression of PTGS2 mRNA]; aurapten inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PTGS2 mRNA] CTD PMID:20865247 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978 		JBrowse link
G Uhrf1 ubiquitin-like, containing PHD and RING finger domains, 1 affects expression ISO aurapten affects the expression of UHRF1 mRNA CTD PMID:23320178 NCBI chr17:56,610,405...56,630,486
Ensembl chr17:56,610,321...56,630,486 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO aurapten inhibits the reaction [DDT results in increased expression of VEGFA mRNA]; aurapten inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of VEGFA mRNA] CTD PMID:20865247 NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295 		JBrowse link
Coumachlor term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Vkorc1 vitamin K epoxide reductase complex, subunit 1 multiple interactions
decreases activity		 ISO coumachlor inhibits the reaction [VKORC1 protein results in increased reduction of Vitamin K 1]; coumachlor inhibits the reaction [VKORC1 protein results in increased reduction of vitamin K1 oxide]
coumachlor results in decreased activity of VKORC1 protein		 CTD PMID:29581108 NCBI chr 7:127,492,235...127,494,833
Ensembl chr 7:127,485,399...127,494,626
Ensembl chr 7:127,485,399...127,494,626 		JBrowse link
G Vkorc1l1 vitamin K epoxide reductase complex, subunit 1-like 1 decreases activity
multiple interactions		 ISO coumachlor results in decreased activity of VKORC1L1 protein
coumachlor inhibits the reaction [VKORC1L1 protein results in increased reduction of Vitamin K 1]; coumachlor inhibits the reaction [VKORC1L1 protein results in increased reduction of vitamin K1 oxide]		 CTD PMID:29581108 NCBI chr 5:129,970,950...130,015,533
Ensembl chr 5:129,970,811...130,015,533 		JBrowse link
coumaphos term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity ISO Coumaphos metabolite results in decreased activity of ACHE protein; Coumaphos results in decreased activity of ACHE protein CTD PMID:30625376 PMID:33844597 NCBI chr 5:137,286,516...137,292,728
Ensembl chr 5:137,285,781...137,292,728 		JBrowse link
G Ar androgen receptor multiple interactions ISO Coumaphos inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein] CTD PMID:33049310 NCBI chr  X:97,192,363...97,366,824
Ensembl chr  X:97,192,375...97,366,821 		JBrowse link
G Esr1 estrogen receptor 1 (alpha) multiple interactions ISO Coumaphos binds to and results in increased activity of ESR1 protein CTD PMID:33049310 NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614 		JBrowse link
G Esr2 estrogen receptor 2 (beta) multiple interactions ISO Coumaphos binds to and results in increased activity of ESR2 protein CTD PMID:33049310 NCBI chr12:76,167,193...76,224,033
Ensembl chr12:76,167,193...76,224,033 		JBrowse link
G Gpat3 glycerol-3-phosphate acyltransferase 3 increases expression ISO Coumaphos results in increased expression of GPAT3 mRNA CTD PMID:26198647 NCBI chr 5:100,994,095...101,046,968
Ensembl chr 5:100,993,579...101,046,968 		JBrowse link
G Lif leukemia inhibitory factor increases expression ISO Coumaphos results in increased expression of LIF mRNA CTD PMID:26198647 NCBI chr11:4,207,587...4,222,514
Ensembl chr11:4,207,557...4,222,514 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO
EXP		 Coumaphos binds to and results in increased activity of NR1I2 protein CTD PMID:33049310 NCBI chr16:38,068,711...38,115,211
Ensembl chr16:38,068,685...38,115,186 		JBrowse link
G Pparg peroxisome proliferator activated receptor gamma multiple interactions EXP
ISO		 Coumaphos binds to and results in increased activity of PPARG protein CTD PMID:33049310 NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360 		JBrowse link
G Rara retinoic acid receptor, alpha increases activity ISO Coumaphos results in increased activity of RARA protein CTD PMID:20143881 NCBI chr11:98,818,626...98,865,768
Ensembl chr11:98,818,644...98,865,768 		JBrowse link
G Slc7a11 solute carrier family 7 (cationic amino acid transporter, y+ system), member 11 increases expression ISO Coumaphos results in increased expression of SLC7A11 mRNA CTD PMID:26198647 NCBI chr 3:50,319,385...50,403,947
Ensembl chr 3:49,846,975...50,398,063 		JBrowse link
G Thrb thyroid hormone receptor beta multiple interactions ISO Coumaphos binds to and results in increased activity of THRB protein CTD PMID:33049310 NCBI chr14:4,429,599...4,810,538
Ensembl chr14:4,431,611...4,809,435 		JBrowse link
G Trp53 transformation related protein 53 affects activity ISO Coumaphos metabolite affects the activity of TP53 protein CTD PMID:35435491 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699 		JBrowse link
Coumatetralyl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Vkorc1 vitamin K epoxide reductase complex, subunit 1 decreases response to substance
multiple interactions
decreases activity		 EXP
ISO		 VKORC1 protein polymorphism results in decreased susceptibility to coumatetralyl
coumatetralyl inhibits the reaction [VKORC1 protein results in increased reduction of Vitamin K 1]
coumatetralyl results in decreased activity of VKORC1 protein		 CTD PMID:27117082 PMID:29581108 NCBI chr 7:127,492,235...127,494,833
Ensembl chr 7:127,485,399...127,494,626
Ensembl chr 7:127,485,399...127,494,626 		JBrowse link
G Vkorc1l1 vitamin K epoxide reductase complex, subunit 1-like 1 decreases activity
multiple interactions		 ISO coumatetralyl results in decreased activity of VKORC1L1 protein
coumatetralyl inhibits the reaction [VKORC1L1 protein results in increased reduction of Vitamin K 1]		 CTD PMID:29581108 NCBI chr 5:129,970,950...130,015,533
Ensembl chr 5:129,970,811...130,015,533 		JBrowse link
dicoumarol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c19 aldo-keto reductase family 1, member C19 decreases activity EXP Dicumarol results in decreased activity of AKR1C19 protein CTD PMID:15930748 NCBI chr13:4,283,499...4,298,360
Ensembl chr13:4,278,699...4,302,842 		JBrowse link
G Akr1c6 aldo-keto reductase family 1, member C6 decreases activity ISO Dicumarol results in decreased activity of AKR1C6 protein CTD PMID:16788056 NCBI chr13:4,484,354...4,507,529
Ensembl chr13:4,484,305...4,507,876 		JBrowse link
G Alb albumin affects binding ISO Dicumarol binds to ALB protein CTD PMID:62049 NCBI chr 5:90,608,729...90,624,461
Ensembl chr 5:90,608,756...90,624,461 		JBrowse link
G Atm ataxia telangiectasia mutated multiple interactions ISO Dicumarol inhibits the reaction [2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone analog results in increased expression of ATM protein modified form] CTD PMID:26630137 NCBI chr 9:53,348,422...53,448,125
Ensembl chr 9:53,350,449...53,448,040 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO [aminochrome 1 co-treated with Dicumarol] results in increased activity of CASP3 protein; Dicumarol promotes the reaction [Doxorubicin results in increased activity of CASP3 protein]; Progesterone inhibits the reaction [Dicumarol promotes the reaction [Doxorubicin results in increased activity of CASP3 protein]]
Dicumarol inhibits the reaction [2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone analog results in decreased expression of CASP3 protein]		 CTD PMID:21427056 PMID:21947872 PMID:26630137 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Cat catalase decreases response to substance
multiple interactions		 ISO CAT protein results in decreased susceptibility to Dicumarol
[Dopamine co-treated with Dicumarol] results in increased expression of CAT mRNA		 CTD PMID:11299314 PMID:17040906 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505 		JBrowse link
G Cd86 CD86 antigen multiple interactions ISO [Dicumarol results in decreased activity of NQO1 protein] inhibits the reaction [Eugenol results in increased expression of CD86 protein] CTD PMID:21742781 NCBI chr16:36,389,318...36,486,439
Ensembl chr16:36,424,231...36,486,443 		JBrowse link
G Cdkn1a cyclin dependent kinase inhibitor 1A multiple interactions ISO Dicumarol inhibits the reaction [diaziquone results in increased expression of CDKN1A mRNA]; Dicumarol inhibits the reaction [Nicotinamide Mononucleotide inhibits the reaction [Hydrogen Peroxide results in increased expression of CDKN1A protein]]; Dicumarol inhibits the reaction [RB1CC1 protein results in increased expression of CDKN1A protein] CTD PMID:9343371 PMID:16061648 PMID:37640247 NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701 		JBrowse link
G Cdkn2a cyclin dependent kinase inhibitor 2A multiple interactions ISO Dicumarol inhibits the reaction [Nicotinamide Mononucleotide inhibits the reaction [Hydrogen Peroxide results in increased expression of CDKN2A protein]] CTD PMID:37640247 NCBI chr 4:89,192,710...89,212,856
Ensembl chr 4:89,192,708...89,212,890 		JBrowse link
G Cxcl15 C-X-C motif chemokine ligand 15 multiple interactions ISO Dicumarol inhibits the reaction [Ozone results in increased expression of CXCL8 mRNA] CTD PMID:19059883 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926 		JBrowse link
G Cycs cytochrome c, somatic multiple interactions ISO [aminochrome 1 co-treated with Dicumarol] affects the localization of CYCS protein CTD PMID:21427056 NCBI chr 6:50,539,543...50,543,549
Ensembl chr 6:50,539,543...50,543,518 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO Dicumarol promotes the reaction [CYP2E1 protein results in increased reduction of tirapazamine]
Dicumarol inhibits the reaction [[CYP2E1 protein co-treated with Paraquat] results in increased expression of KLF6 protein]; Dicumarol inhibits the reaction [[CYP2E1 protein co-treated with Vitamin K 3] results in increased expression of KLF6 protein]		 CTD PMID:7710944 PMID:22486562 NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900 		JBrowse link
G Drd5 dopamine receptor D5 increases expression ISO Dicumarol results in increased expression of DRD5 mRNA CTD PMID:18522901 NCBI chr 5:38,476,742...38,479,868
Ensembl chr 5:38,476,710...38,479,861 		JBrowse link
G Fabp1 fatty acid binding protein 1, liver multiple interactions ISO Dicoumarol inhibits the reaction [3-(p-azidobenzyl)-4-hydroxycoumarin binds to Fabp1 protein] RGD PMID:1939124 RGD:1626448 NCBI chr 6:71,176,863...71,182,018
Ensembl chr 6:71,176,811...71,182,007 		JBrowse link
G Gpr35 G protein-coupled receptor 35 multiple interactions ISO Dicumarol binds to and results in increased activity of GPR35 protein CTD PMID:20919992 NCBI chr 1:92,875,774...92,913,984
Ensembl chr 1:92,878,587...92,914,113 		JBrowse link
G Hspa5 heat shock protein 5 multiple interactions ISO Dicumarol inhibits the reaction [1-nitropyrene results in increased expression of HSPA5 protein] CTD PMID:19460413 NCBI chr 2:34,662,102...34,666,541
Ensembl chr 2:34,661,982...34,667,559 		JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions ISO Dicumarol inhibits the reaction [IGF1 protein results in increased phosphorylation of JUN protein] CTD PMID:11278392 NCBI chr10:87,694,127...87,772,909
Ensembl chr10:87,694,127...87,772,904 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Dicumarol inhibits the reaction [IL1B protein results in increased expression of TP53 protein] CTD PMID:17959154 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Jun jun proto-oncogene multiple interactions ISO Dicumarol inhibits the reaction [IGF1 protein results in increased phosphorylation of JUN protein]; Dicumarol inhibits the reaction [TNF protein results in increased phosphorylation of JUN protein] CTD PMID:11278392 PMID:17669387 NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459 		JBrowse link
G Klf6 Kruppel-like transcription factor 6 multiple interactions ISO Dicumarol inhibits the reaction [[CYP2E1 protein co-treated with Paraquat] results in increased expression of KLF6 protein]; Dicumarol inhibits the reaction [[CYP2E1 protein co-treated with Vitamin K 3] results in increased expression of KLF6 protein] CTD PMID:22486562 NCBI chr13:5,911,488...5,920,392
Ensembl chr13:5,911,481...5,920,393 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions ISO Dicumarol inhibits the reaction [TNF protein results in increased phosphorylation of MAPK1 protein] CTD PMID:17669387 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317 		JBrowse link
G Mapk10 mitogen-activated protein kinase 10 multiple interactions
decreases activity		 ISO Dicumarol inhibits the reaction [Anisomycin results in increased activity of MAPK10 protein]; Dicumarol inhibits the reaction [Sorbitol results in increased activity of MAPK10 protein]; Dicumarol inhibits the reaction [TRAF2 protein results in increased activity of MAPK10 protein]; NQO1 protein inhibits the reaction [Dicumarol results in decreased activity of MAPK10 protein] CTD PMID:10531305 NCBI chr 5:103,056,413...103,359,200
Ensembl chr 5:103,055,814...103,359,200 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions ISO Dicumarol inhibits the reaction [TNF protein results in increased phosphorylation of MAPK3 protein] CTD PMID:17669387 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO Dicumarol inhibits the reaction [Adenosine Diphosphate results in increased phosphorylation of MAPK8 protein]; Dicumarol inhibits the reaction [arsenic trioxide results in increased activity of MAPK8 protein] CTD PMID:14701702 PMID:24466103 NCBI chr14:33,099,855...33,169,213
Ensembl chr14:33,099,855...33,169,115 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions ISO Dicumarol inhibits the reaction [Adenosine Diphosphate results in increased phosphorylation of MAPK9 protein] CTD PMID:24466103 NCBI chr11:49,737,558...49,777,248
Ensembl chr11:49,737,578...49,777,248 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO Dicumarol inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of MMP9 protein]; Dicumarol inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]; hydroquinone inhibits the reaction [Dicumarol inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of MMP9 protein]] CTD PMID:17669387 NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770 		JBrowse link
G Mt1 metallothionein 1 multiple interactions EXP Dicumarol inhibits the reaction [Cadmium Chloride results in increased expression of MT1 mRNA]; Dicumarol inhibits the reaction [zinc chloride results in increased expression of MT1 mRNA]; Dicumarol inhibits the reaction [Zinc Sulfate results in increased expression of MT1 mRNA] CTD PMID:11551972 PMID:15142038 NCBI chr 8:94,905,214...94,906,955
Ensembl chr 8:94,905,710...94,906,955 		JBrowse link
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 multiple interactions ISO Dicumarol inhibits the reaction [Lipopolysaccharides results in increased activity of NFKB1 protein]; Dicumarol inhibits the reaction [TNF protein results in increased activity of NFKB1 protein] CTD PMID:10531305 NCBI chr 3:135,290,416...135,397,422
Ensembl chr 3:135,290,416...135,397,308 		JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 multiple interactions
decreases activity
decreases expression
affects response to substance		 ISO
EXP		 [aristolochic acid I co-treated with Dicumarol] results in increased expression of NQO1 protein; [Dicumarol results in decreased activity of NQO1 protein] inhibits the reaction [Eugenol results in increased expression of CD86 protein]; [Dicumarol results in decreased activity of NQO1 protein] which results in decreased susceptibility to Mitomycin; [Dicumarol results in decreased activity of NQO1 protein] which results in decreased susceptibility to Streptonigrin; aristolochic acid I inhibits the reaction [Dicumarol results in decreased activity of NQO1 protein]; Dicumarol inhibits the reaction [[arsenite results in increased expression of NQO1 protein] which results in increased susceptibility to Mitomycin]; Dicumarol inhibits the reaction [NQO1 protein results in decreased susceptibility to arsenite]; Dicumarol inhibits the reaction [NQO1 protein results in increased metabolism of Mitomycin]; Dicumarol inhibits the reaction [NQO1 protein results in increased reduction of 2,6-Dichloroindophenol]; Dicumarol inhibits the reaction [TP53 protein binds to NQO1 protein]; NQO1 protein inhibits the reaction [Dicumarol results in decreased activity of MAPK10 protein]
[Dicumarol results in decreased activity of NQO1 protein] which results in decreased activity of diaziquone; Dicumarol results in decreased activity of NQO1 protein
Dicumarol results in decreased expression of NQO1 protein
[Dicumarol results in decreased activity of NQO1 protein] which results in decreased reduction of Chromium; Dicumarol inhibits the reaction [Benzo(a)pyrene results in increased activity of NQO1 protein]; Dicumarol inhibits the reaction [NQO1 protein inhibits the reaction [Vitamin K 3 results in increased chemical synthesis of Hydrogen Peroxide]]; Dicumarol inhibits the reaction [Progesterone results in increased activity of NQO1 protein]; Dicumarol inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of NQO1 protein]
[Dicumarol results in decreased activity of NQO1 protein] which results in decreased abundance of aristolactam I; [Dicumarol results in decreased activity of NQO1 protein] which results in increased abundance of aristolochic acid I; [Dicumarol results in decreased activity of NQO1 protein] which results in increased abundance of aristolochic acid I metabolite
NQO1 protein affects the susceptibility to Dicumarol		 CTD PMID:1379126 PMID:1701346 PMID:2113030 PMID:8572925 PMID:10092053 More... NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838 		JBrowse link
G Rb1 RB transcriptional corepressor 1 increases phosphorylation ISO Dicumarol results in increased phosphorylation of RB1 protein CTD PMID:15896341 NCBI chr14:73,430,298...73,563,446
Ensembl chr14:73,421,113...73,563,262 		JBrowse link
G Rb1cc1 RB1-inducible coiled-coil 1 multiple interactions ISO Dicumarol inhibits the reaction [RB1CC1 protein results in increased expression of CDKN1A protein]; Dicumarol inhibits the reaction [RB1CC1 protein results in increased expression of TP53 protein]; Dicumarol inhibits the reaction [RB1CC1 protein results in increased stability of TP53 protein] CTD PMID:16061648 NCBI chr 1:6,284,858...6,346,599
Ensembl chr 1:6,276,421...6,346,872 		JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions ISO Dicumarol inhibits the reaction [Lipopolysaccharides results in increased activity of RELA protein]; Dicumarol inhibits the reaction [TNF protein affects the localization of RELA protein]; Dicumarol inhibits the reaction [TNF protein results in increased activity of RELA protein] CTD PMID:10531305 PMID:17669387 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158 		JBrowse link
G Slc30a1 solute carrier family 30 (zinc transporter), member 1 multiple interactions EXP Dicumarol inhibits the reaction [Cadmium Chloride results in increased expression of SLC30A1 mRNA]; Dicumarol inhibits the reaction [Zinc Sulfate results in increased expression of SLC30A1 mRNA] CTD PMID:15142038 NCBI chr 1:191,638,810...191,645,359
Ensembl chr 1:191,638,879...191,645,359 		JBrowse link
G Sod1 superoxide dismutase 1, soluble multiple interactions ISO [Dopamine co-treated with Dicumarol co-treated with Copper Sulfate] results in decreased expression of SOD1 mRNA CTD PMID:11299314 NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217 		JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial decreases response to substance
multiple interactions		 ISO SOD2 protein results in decreased susceptibility to Dicumarol
[Dopamine co-treated with Dicumarol co-treated with Copper Sulfate] results in decreased expression of SOD2 mRNA		 CTD PMID:11299314 PMID:17040906 NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Dicumarol inhibits the reaction [TNF protein affects the localization of RELA protein]; Dicumarol inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]; Dicumarol inhibits the reaction [TNF protein results in increased activity of RELA protein]; Dicumarol inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of MMP9 protein]; Dicumarol inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]; Dicumarol inhibits the reaction [TNF protein results in increased phosphorylation of JUN protein]; Dicumarol inhibits the reaction [TNF protein results in increased phosphorylation of MAPK1 protein]; Dicumarol inhibits the reaction [TNF protein results in increased phosphorylation of MAPK3 protein]; hydroquinone inhibits the reaction [Dicumarol inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of MMP9 protein]] CTD PMID:10531305 PMID:17669387 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Traf2 TNF receptor-associated factor 2 multiple interactions ISO Dicumarol inhibits the reaction [TRAF2 protein results in increased activity of MAPK10 protein] CTD PMID:10531305 NCBI chr 2:25,407,994...25,436,952
Ensembl chr 2:25,407,994...25,436,952 		JBrowse link
G Trp53 transformation related protein 53 multiple interactions
decreases expression
increases degradation		 ISO Dicumarol inhibits the reaction [2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone analog results in increased expression of TP53 protein modified form]; Dicumarol inhibits the reaction [2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone analog results in increased expression of TP53 protein]; Dicumarol inhibits the reaction [IL1B protein results in increased expression of TP53 protein]; Dicumarol inhibits the reaction [RB1CC1 protein results in increased expression of TP53 protein]; Dicumarol inhibits the reaction [RB1CC1 protein results in increased stability of TP53 protein]; Dicumarol inhibits the reaction [TP53 protein binds to NQO1 protein]
Dicumarol results in decreased expression of TP53 protein
Dicumarol results in increased degradation of TP53 protein		 CTD PMID:14634213 PMID:16061648 PMID:17959154 PMID:22692362 PMID:26630137 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699 		JBrowse link
G Vkorc1 vitamin K epoxide reductase complex, subunit 1 decreases activity
multiple interactions		 ISO Dicumarol results in decreased activity of VKORC1 protein
Dicumarol inhibits the reaction [VKORC1 protein results in increased reduction of Vitamin K 1]		 CTD PMID:29581108 NCBI chr 7:127,492,235...127,494,833
Ensembl chr 7:127,485,399...127,494,626
Ensembl chr 7:127,485,399...127,494,626 		JBrowse link
G Vkorc1l1 vitamin K epoxide reductase complex, subunit 1-like 1 multiple interactions
decreases activity		 ISO Dicumarol inhibits the reaction [VKORC1L1 protein results in increased reduction of Vitamin K 1]
Dicumarol results in decreased activity of VKORC1L1 protein		 CTD PMID:29581108 NCBI chr 5:129,970,950...130,015,533
Ensembl chr 5:129,970,811...130,015,533 		JBrowse link
esculetin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agtr1a angiotensin II receptor, type 1a multiple interactions ISO esculetin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of AGTR1A mRNA]; esculetin inhibits the reaction [Dietary Fats results in increased expression of AGTR1A mRNA] CTD PMID:28946194 NCBI chr13:30,520,339...30,566,850
Ensembl chr13:30,520,424...30,566,850 		JBrowse link
G Agtr2 angiotensin II receptor, type 2 multiple interactions ISO esculetin inhibits the reaction [Dietary Fats results in increased expression of AGTR2 mRNA]; esculetin promotes the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of AGTR2 mRNA] CTD PMID:28946194 NCBI chr  X:21,350,863...21,355,072
Ensembl chr  X:21,350,783...21,355,403 		JBrowse link
G Akt1 thymoma viral proto-oncogene 1 increases phosphorylation ISO esculetin results in increased phosphorylation of AKT1 protein CTD PMID:24995577 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318 		JBrowse link
G Alox15 arachidonate 15-lipoxygenase decreases expression ISO esculetin results in decreased expression of ALOX15 protein CTD PMID:30171828 NCBI chr11:70,234,973...70,279,465
Ensembl chr11:70,234,978...70,242,857 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases expression ISO esculetin results in increased expression of BAK1 protein CTD PMID:26388407 NCBI chr17:27,238,786...27,247,601
Ensembl chr17:27,238,784...27,247,983 		JBrowse link
G Bax BCL2-associated X protein multiple interactions
increases expression
affects expression
affects localization		 ISO [esculetin co-treated with Paclitaxel] results in increased expression of BAX protein
esculetin results in increased expression of BAX protein
esculetin affects the expression of BAX protein
esculetin affects the localization of BAX protein		 CTD PMID:16051289 PMID:19786087 PMID:24995577 PMID:26388407 PMID:31313495 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 affects expression
decreases expression		 ISO esculetin affects the expression of BCL2 protein
esculetin results in decreased expression of BCL2 protein		 CTD PMID:24995577 PMID:26388407 PMID:31313495 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Bcl2l1 BCL2-like 1 multiple interactions
decreases expression		 ISO [esculetin co-treated with Paclitaxel] results in decreased expression of BCL2L1 protein
esculetin results in decreased expression of BCL2L1 protein		 CTD PMID:16051289 PMID:26388407 NCBI chr 2:152,600,652...152,673,632
Ensembl chr 2:152,622,588...152,673,648 		JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions ISO [arsenic trioxide co-treated with esculetin] results in increased cleavage of BID protein CTD PMID:19428345 NCBI chr 6:120,870,080...120,894,074
Ensembl chr 6:120,868,891...120,893,814 		JBrowse link
G Bmp6 bone morphogenetic protein 6 multiple interactions ISO esculetin inhibits the reaction [Streptozocin results in decreased expression of BMP6 mRNA] CTD PMID:21450970 NCBI chr13:38,529,098...38,684,283
Ensembl chr13:38,529,083...38,684,278 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
increases activity		 ISO [esculetin co-treated with Paclitaxel] results in increased cleavage of and results in increased activity of CASP3 protein
esculetin results in increased cleavage of CASP3 protein
esculetin results in increased activity of CASP3 protein		 CTD PMID:16051289 PMID:24995577 PMID:26388407 PMID:31313495 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Casp7 caspase 7 increases cleavage ISO esculetin results in increased cleavage of CASP7 protein CTD PMID:31313495 NCBI chr19:56,382,640...56,430,780
Ensembl chr19:56,385,561...56,430,776 		JBrowse link
G Casp8 caspase 8 multiple interactions ISO [esculetin co-treated with Paclitaxel] results in increased cleavage of and results in increased activity of CASP8 protein CTD PMID:16051289 NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662 		JBrowse link
G Casp9 caspase 9 increases activity
increases cleavage		 ISO esculetin results in increased activity of CASP9 protein
esculetin results in increased cleavage of CASP9 protein		 CTD PMID:24995577 PMID:26388407 PMID:31313495 NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions EXP esculetin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of CCL2 protein] CTD PMID:27769711 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279 		JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO esculetin results in decreased expression of CCND1 protein CTD PMID:21600278 PMID:31313495 NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662 		JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression
multiple interactions		 ISO esculetin results in decreased expression of CDK2 protein
esculetin promotes the reaction [CDKN1A protein binds to CDK2 protein]; SB 203580 inhibits the reaction [esculetin results in decreased expression of CDK2 protein]		 CTD PMID:21600278 NCBI chr10:128,533,807...128,540,920
Ensembl chr10:128,533,808...128,540,900 		JBrowse link
G Cdk4 cyclin dependent kinase 4 decreases expression
multiple interactions		 ISO esculetin results in decreased expression of CDK4 protein
esculetin promotes the reaction [CDKN1A protein binds to CDK4 protein]; SB 203580 inhibits the reaction [esculetin results in decreased expression of CDK4 protein]		 CTD PMID:21600278 NCBI chr10:126,899,404...126,903,157
Ensembl chr10:126,899,403...126,903,789 		JBrowse link
G Cdkn1a cyclin dependent kinase inhibitor 1A multiple interactions
increases expression		 ISO esculetin promotes the reaction [CDKN1A protein binds to CDK2 protein]; esculetin promotes the reaction [CDKN1A protein binds to CDK4 protein]; SB 203580 inhibits the reaction [esculetin results in increased expression of CDKN1A protein] CTD PMID:21600278 PMID:31313495 NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701 		JBrowse link
G Cdkn1b cyclin dependent kinase inhibitor 1B increases expression ISO esculetin results in increased expression of CDKN1B protein CTD PMID:31313495 NCBI chr 6:134,897,364...134,902,488
Ensembl chr 6:134,897,364...134,902,476 		JBrowse link
G Comt catechol-O-methyltransferase increases methylation ISO COMT protein results in increased methylation of esculetin CTD PMID:11160877 NCBI chr16:18,225,632...18,247,006
Ensembl chr16:18,225,636...18,245,602 		JBrowse link
G Cycs cytochrome c, somatic multiple interactions ISO [arsenic trioxide co-treated with esculetin] affects the localization of CYCS protein; [esculetin co-treated with Paclitaxel] affects the localization of CYCS protein CTD PMID:16051289 PMID:19428345 NCBI chr 6:50,539,543...50,543,549
Ensembl chr 6:50,539,543...50,543,518 		JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO [esculetin co-treated with Paclitaxel] results in increased expression of FAS protein CTD PMID:16051289 NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172 		JBrowse link
G Fasl Fas ligand multiple interactions ISO [esculetin co-treated with Paclitaxel] results in increased expression of FASLG protein CTD PMID:16051289 NCBI chr 1:161,608,260...161,616,064
Ensembl chr 1:161,608,258...161,616,064 		JBrowse link
G Fasn fatty acid synthase multiple interactions EXP esculetin promotes the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of FASN mRNA] CTD PMID:27769711 NCBI chr11:120,696,784...120,715,992
Ensembl chr11:120,696,672...120,715,373 		JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO esculetin inhibits the reaction [Streptozocin results in increased expression of FN1 mRNA]; esculetin inhibits the reaction [Streptozocin results in increased expression of FN1 protein] CTD PMID:21450970 NCBI chr 1:71,624,632...71,692,439
Ensembl chr 1:71,624,679...71,692,359 		JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 multiple interactions EXP esculetin promotes the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased activity of G6PC1 protein] CTD PMID:27769711 NCBI chr11:101,258,542...101,268,729
Ensembl chr11:101,258,387...101,268,729 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP esculetin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of IL6 mRNA]; esculetin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of IL6 protein] CTD PMID:27769711 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions
increases phosphorylation		 ISO [esculetin co-treated with Paclitaxel] results in decreased expression of MAPK1 protein; esculetin results in decreased phosphorylation of and results in decreased activity of MAPK1 protein
esculetin results in increased phosphorylation of MAPK1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [esculetin results in increased phosphorylation of MAPK1 protein]; SB 203580 inhibits the reaction [esculetin results in increased phosphorylation of MAPK1 protein]		 CTD PMID:16051289 PMID:21600278 PMID:24995577 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317 		JBrowse link
G Mapk14 mitogen-activated protein kinase 14 multiple interactions ISO [esculetin co-treated with Paclitaxel] results in decreased expression of MAPK14 protein; esculetin results in decreased phosphorylation of and results in decreased activity of MAPK14 protein CTD PMID:16051289 NCBI chr17:28,910,316...28,967,379
Ensembl chr17:28,910,303...28,967,380 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions
increases phosphorylation		 ISO [esculetin co-treated with Paclitaxel] results in decreased expression of MAPK3 protein; esculetin results in decreased phosphorylation of and results in decreased activity of MAPK3 protein
esculetin results in increased phosphorylation of MAPK3 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [esculetin results in increased phosphorylation of MAPK3 protein]; SB 203580 inhibits the reaction [esculetin results in increased phosphorylation of MAPK3 protein]		 CTD PMID:16051289 PMID:21600278 PMID:24995577 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions
increases phosphorylation
increases expression		 ISO [esculetin co-treated with Paclitaxel] results in increased expression of MAPK8 protein
esculetin results in increased phosphorylation of MAPK8 protein
esculetin results in increased expression of MAPK8 protein		 CTD PMID:16051289 PMID:19786087 NCBI chr14:33,099,855...33,169,213
Ensembl chr14:33,099,855...33,169,115 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions
increases expression		 ISO [esculetin co-treated with Paclitaxel] results in increased expression of MAPK9 protein
esculetin results in increased expression of MAPK9 protein		 CTD PMID:16051289 NCBI chr11:49,737,558...49,777,248
Ensembl chr11:49,737,578...49,777,248 		JBrowse link
G Mmp13 matrix metallopeptidase 13 multiple interactions ISO esculetin inhibits the reaction [Streptozocin results in increased expression of MMP13 mRNA] CTD PMID:21450970 NCBI chr 9:7,272,514...7,283,333
Ensembl chr 9:7,272,514...7,283,331 		JBrowse link
G Myd88 myeloid differentiation primary response gene 88 multiple interactions EXP esculetin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of MYD88 mRNA] CTD PMID:27769711 NCBI chr 9:119,165,000...119,169,084
Ensembl chr 9:119,165,000...119,170,477 		JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 increases localization
affects localization		 ISO esculetin results in increased localization of NFE2L2 protein
esculetin affects the localization of NFE2L2 protein		 CTD PMID:20933534 PMID:30171828 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985 		JBrowse link
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 affects localization ISO esculetin affects the localization of NFKB1 protein CTD PMID:30171828 NCBI chr 3:135,290,416...135,397,422
Ensembl chr 3:135,290,416...135,397,308 		JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions EXP esculetin promotes the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA] CTD PMID:16212885 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080 		JBrowse link
G Nos3 nitric oxide synthase 3, endothelial cell multiple interactions ISO esculetin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of NOS3 mRNA]; esculetin inhibits the reaction [Dietary Fats results in decreased expression of NOS3 mRNA] CTD PMID:28946194 NCBI chr 5:24,569,772...24,589,472
Ensembl chr 5:24,569,808...24,589,472 		JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 multiple interactions
increases expression		 ISO esculetin results in increased expression of and results in increased activity of NQO1 protein
esculetin results in increased expression of NQO1 mRNA		 CTD PMID:20933534 NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 increases cleavage ISO esculetin results in increased cleavage of PARP1 protein CTD PMID:26388407 PMID:31313495 NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819 		JBrowse link
G Pparg peroxisome proliferator activated receptor gamma multiple interactions ISO
EXP		 esculetin inhibits the reaction [Streptozocin results in decreased expression of PPARG protein]; esculetin inhibits the reaction [Streptozocin results in increased expression of PPARG protein]
esculetin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of PPARG mRNA]		 CTD PMID:21450970 PMID:27769711 NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360 		JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) affects localization ISO esculetin affects the localization of RELA protein CTD PMID:30171828 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158 		JBrowse link
G Sod1 superoxide dismutase 1, soluble affects expression ISO esculetin affects the expression of SOD1 protein CTD PMID:30171828 NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217 		JBrowse link
G Sp1 trans-acting transcription factor 1 decreases expression ISO esculetin results in decreased expression of SP1 protein CTD PMID:31313495 NCBI chr15:102,314,751...102,344,839
Ensembl chr15:102,314,578...102,344,839 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO esculetin inhibits the reaction [Streptozocin results in increased expression of TGFB1 protein] CTD PMID:21450970 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions EXP esculetin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of TLR4 mRNA] CTD PMID:27769711 NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP esculetin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of TNF mRNA]; esculetin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of TNF protein] CTD PMID:27769711 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Tnfrsf10b tumor necrosis factor receptor superfamily, member 10b increases expression ISO esculetin results in increased expression of TNFRSF10A protein CTD PMID:19786087 NCBI chr14:70,004,921...70,021,860
Ensembl chr14:70,004,921...70,021,860 		JBrowse link
G Trp53 transformation related protein 53 increases degradation
increases expression		 ISO esculetin results in increased degradation of TP53 protein
esculetin results in increased expression of TP53 protein		 CTD PMID:14634213 PMID:31313495 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699 		JBrowse link
G Usp16 ubiquitin specific peptidase 16 multiple interactions ISO esculetin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of USP16 mRNA]; esculetin inhibits the reaction [Dietary Fats results in increased expression of USP16 mRNA] CTD PMID:28946194 NCBI chr16:87,251,833...87,280,403
Ensembl chr16:87,251,591...87,280,405 		JBrowse link
G Usp22 ubiquitin specific peptidase 22 multiple interactions ISO esculetin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of USP22 mRNA]; esculetin inhibits the reaction [Dietary Fats results in increased expression of USP22 mRNA] CTD PMID:28946194 NCBI chr11:61,042,607...61,065,885
Ensembl chr11:61,042,611...61,065,881 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO esculetin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of VCAM1 mRNA]; esculetin inhibits the reaction [Dietary Fats results in increased expression of VCAM1 mRNA] CTD PMID:28946194 NCBI chr 3:115,903,669...115,923,337
Ensembl chr 3:115,903,598...115,923,337 		JBrowse link
ethyl biscoumacetate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F10 coagulation factor X multiple interactions
decreases expression		 ISO Vitamin K 3 inhibits the reaction [Ethyl Biscoumacetate results in decreased expression of F10 protein] CTD PMID:6768192 NCBI chr 8:13,087,308...13,106,676
Ensembl chr 8:13,087,308...13,106,676 		JBrowse link
fraxetin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 thymoma viral proto-oncogene 1 multiple interactions
decreases phosphorylation		 EXP
ISO		 fraxetin inhibits the reaction [Isoflurane results in decreased phosphorylation of AKT1 protein]
fraxetin results in decreased phosphorylation of AKT1 protein		 CTD PMID:34553399 PMID:37867445 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318 		JBrowse link
G Bax BCL2-associated X protein decreases expression
increases expression
increases expression 		ISO fraxetin results in decreased expression of BAX protein
fraxetin results in increased expression of BAX mRNA; fraxetin results in increased expression of BAX protein
Fraxetin increases expression of BAX protein in colorectum		 CTD
RGD		 PMID:15996779 PMID:37867445 PMID:32504672 RGD:125097526 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 decreases expression ISO Fraxetin decreases expression of BCL2 protein in colorectum
fraxetin results in decreased expression of BCL2 mRNA; fraxetin results in decreased expression of BCL2 protein		 CTD
RGD		 PMID:37867445 PMID:32504672 RGD:125097526 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Casp3 caspase 3 decreases activity
increases cleavage		 ISO fraxetin results in decreased activity of CASP3 protein
fraxetin results in increased cleavage of CASP3 protein		 CTD PMID:15996779 PMID:37867445 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Casp9 caspase 9 decreases activity ISO fraxetin results in decreased activity of CASP9 protein CTD PMID:15996779 NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287 		JBrowse link
G Cat catalase multiple interactions ISO fraxetin inhibits the reaction [Rotenone results in increased expression of and results in increased activity of CAT protein] CTD PMID:15904944 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505 		JBrowse link
G Ccna2 cyclin A2 decreases expression ISO Fraxetin decreases expression of CCNA2 protein in colorectum RGD PMID:32504672 RGD:125097526 NCBI chr 3:36,619,014...36,627,187
Ensembl chr 3:36,619,014...36,626,299 		JBrowse link
G Ccne1 cyclin E1 decreases expression ISO Fraxetin decreases expression of CCNE1 protein in colorectum RGD PMID:32504672 RGD:125097526 NCBI chr 7:37,797,409...37,806,915
Ensembl chr 7:37,797,409...37,806,959 		JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO Fraxetin decreases expression of CDK2 protein in colorectum RGD PMID:32504672 RGD:125097526 NCBI chr10:128,533,807...128,540,920
Ensembl chr10:128,533,808...128,540,900 		JBrowse link
G Cycs cytochrome c, somatic affects localization ISO fraxetin affects the localization of CYCS protein CTD PMID:15996779 NCBI chr 6:50,539,543...50,543,549
Ensembl chr 6:50,539,543...50,543,518 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO fraxetin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL6 mRNA] CTD PMID:30496664 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Jak2 Janus kinase 2 decreases phosphorylation ISO Fraxetin decreases phosphorylation of JAK2 protein in colorectum RGD PMID:32504672 RGD:125097526 NCBI chr19:29,229,006...29,290,495
Ensembl chr19:29,229,228...29,290,480 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 decreases phosphorylation ISO fraxetin results in decreased phosphorylation of MAPK8 protein CTD PMID:37867445 NCBI chr14:33,099,855...33,169,213
Ensembl chr14:33,099,855...33,169,115 		JBrowse link
G Mki67 antigen identified by monoclonal antibody Ki 67 decreases expression ISO fraxetin results in decreased expression of MKI67 protein CTD PMID:37867445 NCBI chr 7:135,291,513...135,318,286
Ensembl chr 7:135,291,513...135,318,090 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 increases cleavage ISO fraxetin results in increased cleavage of PARP1 protein CTD PMID:37867445 NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819 		JBrowse link
G Skp2 S-phase kinase-associated protein 2 decreases expression ISO Fraxetin decreases expression of SKP2 mRNA and protein in colorectum RGD PMID:32504672 RGD:125097526 NCBI chr15:9,112,070...9,155,512
Ensembl chr15:9,112,073...9,155,512 		JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial multiple interactions ISO fraxetin inhibits the reaction [Rotenone results in increased expression of and results in increased activity of SOD2 protein] CTD PMID:15904944 NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 decreases phosphorylation ISO Fraxetin decreases phosphorylation of STAT3 protein in colorectum RGD PMID:32504672 RGD:125097526 NCBI chr11:100,777,632...100,830,447
Ensembl chr11:100,775,924...100,830,366 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO fraxetin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of TNF mRNA] CTD PMID:30496664 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
novobiocin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg2 ATP binding cassette subfamily G member 2 (Junior blood group) multiple interactions
decreases activity		 ISO [Novobiocin results in decreased activity of ABCG2 protein] which results in decreased secretion of Rosuvastatin Calcium
Novobiocin inhibits the reaction [5-Methoxypsoralen results in decreased activity of ABCG2 protein]; Novobiocin inhibits the reaction [[5-Methoxypsoralen results in decreased activity of ABCG2 protein] which results in decreased export of and results in increased abundance of Mitoxantrone]; Novobiocin inhibits the reaction [[Methoxsalen results in decreased activity of ABCG2 protein] which results in decreased export of and results in increased abundance of Mitoxantrone]; Novobiocin inhibits the reaction [ABCG2 protein results in increased uptake of lucifer yellow]; Novobiocin inhibits the reaction [Methoxsalen results in decreased activity of ABCG2 protein]		 CTD PMID:19853032 PMID:29079042 PMID:32305507 PMID:35550413 NCBI chr 6:58,561,476...58,669,436
Ensembl chr 6:58,561,508...58,672,661 		JBrowse link
G Akt1 thymoma viral proto-oncogene 1 increases degradation ISO Novobiocin analog results in increased degradation of AKT1 protein CTD PMID:20711301 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318 		JBrowse link
G Cd38 CD38 antigen increases expression ISO Novobiocin results in increased expression of CD38 mRNA; Novobiocin results in increased expression of CD38 protein CTD PMID:11853877 NCBI chr 5:44,026,153...44,069,714
Ensembl chr 5:44,025,895...44,069,717 		JBrowse link
G Cdh2 cadherin 2 decreases expression ISO Novobiocin results in decreased expression of CDH2 protein CTD PMID:11853877 NCBI chr18:16,721,934...16,942,303
Ensembl chr18:16,721,934...16,942,303 		JBrowse link
G Ggt1 gamma-glutamyltransferase 1 increases activity EXP Novobiocin results in increased activity of GGT1 protein CTD PMID:1739614 NCBI chr10:75,396,910...75,422,027
Ensembl chr10:75,397,438...75,422,034 		JBrowse link
phenprocoumon term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2c65 cytochrome P450, family 2, subfamily c, polypeptide 65 affects response to substance
increases metabolic processing		 ISO CYP2C9 gene polymorphism affects the susceptibility to Phenprocoumon
CYP2C9 protein results in increased metabolism of Phenprocoumon		 CTD PMID:18698879 PMID:19082874 NCBI chr19:39,049,450...39,082,392
Ensembl chr19:39,049,459...39,082,388 		JBrowse link
G F10 coagulation factor X decreases activity ISO Phenprocoumon results in decreased activity of F10 protein CTD PMID:3490277 NCBI chr 8:13,087,308...13,106,676
Ensembl chr 8:13,087,308...13,106,676 		JBrowse link
G F2 coagulation factor II decreases activity ISO Phenprocoumon results in decreased activity of F2 protein CTD PMID:3490277 NCBI chr 2:91,442,742...91,466,799
Ensembl chr 2:91,455,665...91,466,759 		JBrowse link
G F5 coagulation factor V decreases activity ISO Phenprocoumon results in decreased activity of F5 protein CTD PMID:3490277 NCBI chr 1:163,979,396...164,048,539
Ensembl chr 1:163,979,407...164,047,846 		JBrowse link
G F7 coagulation factor VII decreases activity ISO Phenprocoumon results in decreased activity of F7 protein CTD PMID:3490277 NCBI chr 8:13,075,499...13,085,809
Ensembl chr 8:13,076,034...13,085,809 		JBrowse link
G F9 coagulation factor IX decreases activity ISO Phenprocoumon results in decreased activity of F9 protein CTD PMID:3490277 NCBI chr  X:59,044,675...59,076,120
Ensembl chr  X:59,044,824...59,076,119 		JBrowse link
G Ggcx gamma-glutamyl carboxylase increases activity ISO Phenprocoumon results in increased activity of GGCX protein CTD PMID:3490277 NCBI chr 6:72,391,262...72,407,696
Ensembl chr 6:72,391,291...72,407,695 		JBrowse link
G Hsf1 heat shock factor 1 decreases activity ISO Phenprocoumon results in decreased activity of HSF1 protein CTD PMID:34170685 NCBI chr15:76,361,562...76,385,355
Ensembl chr15:76,361,622...76,386,113 		JBrowse link
G Vkorc1 vitamin K epoxide reductase complex, subunit 1 affects response to substance
decreases activity
multiple interactions
decreases response to substance		 ISO VKORC1 gene polymorphism affects the susceptibility to Phenprocoumon; VKORC1 intron SNP affects the susceptibility to Phenprocoumon
Phenprocoumon results in decreased activity of VKORC1 protein
Phenprocoumon inhibits the reaction [VKORC1 protein results in increased reduction of Vitamin K 1]
VKORC1 protein polymorphism results in decreased susceptibility to Phenprocoumon		 CTD PMID:15536456 PMID:16201835 PMID:17036862 PMID:18698879 PMID:29581108 NCBI chr 7:127,492,235...127,494,833
Ensembl chr 7:127,485,399...127,494,626
Ensembl chr 7:127,485,399...127,494,626 		JBrowse link
G Vkorc1l1 vitamin K epoxide reductase complex, subunit 1-like 1 multiple interactions
decreases activity		 ISO Phenprocoumon inhibits the reaction [VKORC1L1 protein results in increased reduction of Vitamin K 1]
Phenprocoumon results in decreased activity of VKORC1L1 protein		 CTD PMID:29581108 NCBI chr 5:129,970,950...130,015,533
Ensembl chr 5:129,970,811...130,015,533 		JBrowse link
scoparone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 thymoma viral proto-oncogene 1 multiple interactions EXP scoparone affects the reaction [[Dietary Fats co-treated with Dietary Sugars co-treated with Diethylnitrosamine] results in increased phosphorylation of AKT1 protein] CTD PMID:37436232 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318 		JBrowse link
G Alb albumin multiple interactions EXP scoparone inhibits the reaction [[Dietary Fats co-treated with Dietary Sugars co-treated with Diethylnitrosamine] results in decreased expression of ALB protein] CTD PMID:37436232 NCBI chr 5:90,608,729...90,624,461
Ensembl chr 5:90,608,756...90,624,461 		JBrowse link
G Bax BCL2-associated X protein increases expression ISO scoparone results in increased expression of BAX protein CTD PMID:37449671 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 decreases expression ISO scoparone results in decreased expression of BCL2 protein CTD PMID:37449671 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Casp3 caspase 3 increases cleavage ISO scoparone results in increased cleavage of CASP3 protein CTD PMID:37449671 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO
EXP		 scoparone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CCL2 mRNA]; scoparone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of CCL2 protein]
scoparone inhibits the reaction [Diethylnitrosamine promotes the reaction [[Dietary Fats co-treated with Dietary Sugars] results in increased expression of CCL2 mRNA]]; scoparone inhibits the reaction [Diethylnitrosamine promotes the reaction [[Dietary Fats co-treated with Dietary Sugars] results in increased expression of CCL2 protein]]		 CTD PMID:16376386 PMID:37436232 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279 		JBrowse link
G Cdc42 cell division cycle 42 decreases expression ISO scoparone results in decreased expression of CDC42 mRNA CTD PMID:37449671 NCBI chr 4:137,047,011...137,085,007
Ensembl chr 4:137,047,007...137,085,031 		JBrowse link
G Cxcl15 C-X-C motif chemokine ligand 15 multiple interactions ISO scoparone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CXCL8 mRNA]; scoparone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of CXCL8 protein] CTD PMID:16376386 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926 		JBrowse link
G Dct dopachrome tautomerase increases expression EXP scoparone results in increased expression of DCT mRNA CTD PMID:17049123 NCBI chr14:118,250,202...118,289,658
Ensembl chr14:118,250,202...118,289,656 		JBrowse link
G Gpt glutamic pyruvic transaminase, soluble multiple interactions EXP [Dietary Sugars co-treated with Dietary Fats co-treated with scoparone] results in increased expression of GPT protein; scoparone inhibits the reaction [Diethylnitrosamine promotes the reaction [[Dietary Sugars co-treated with Dietary Fats] results in increased expression of GPT protein]] CTD PMID:37436232 NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886 		JBrowse link
G Ifnb1 interferon beta 1, fibroblast multiple interactions EXP scoparone inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Galactose] results in increased expression of IFNB1 protein] CTD PMID:23535186 NCBI chr 4:88,440,253...88,441,083
Ensembl chr 4:88,440,262...88,441,011 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP scoparone affects the reaction [[Dietary Fats co-treated with Dietary Sugars co-treated with Diethylnitrosamine] results in increased metabolism of IL1B protein] CTD PMID:37436232 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP scoparone inhibits the reaction [[Galactose co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of IL6 protein] CTD PMID:23535186 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Irf3 interferon regulatory factor 3 multiple interactions EXP scoparone inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Galactose] results in increased phosphorylation of IRF3 protein] CTD PMID:23535186 NCBI chr 7:44,647,072...44,652,272
Ensembl chr 7:44,647,072...44,652,272 		JBrowse link
G Jun jun proto-oncogene multiple interactions EXP scoparone inhibits the reaction [[Galactose co-treated with lipopolysaccharide, Escherichia coli O111 B4] affects the localization of and results in increased expression of JUN protein modified form] CTD PMID:23535186 NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459 		JBrowse link
G Mapk14 mitogen-activated protein kinase 14 multiple interactions EXP scoparone affects the reaction [[Dietary Fats co-treated with Dietary Sugars co-treated with Diethylnitrosamine] results in increased phosphorylation of MAPK14 protein] CTD PMID:37436232 NCBI chr17:28,910,316...28,967,379
Ensembl chr17:28,910,303...28,967,380 		JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression ISO scoparone results in decreased expression of MMP2 mRNA CTD PMID:37449671 NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048 		JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression
multiple interactions		 ISO
EXP		 scoparone results in decreased expression of MMP9 mRNA
scoparone affects the reaction [[Dietary Fats co-treated with Dietary Sugars co-treated with Diethylnitrosamine] results in increased expression of MMP9 protein]; scoparone inhibits the reaction [Diethylnitrosamine promotes the reaction [[Dietary Fats co-treated with Dietary Sugars] results in increased expression of MMP9 mRNA]]		 CTD PMID:37436232 PMID:37449671 NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770 		JBrowse link
G Myd88 myeloid differentiation primary response gene 88 multiple interactions EXP scoparone inhibits the reaction [[Galactose co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of MYD88 protein] CTD PMID:23535186 NCBI chr 9:119,165,000...119,169,084
Ensembl chr 9:119,165,000...119,170,477 		JBrowse link
G Myl1 myosin, light polypeptide 1 decreases phosphorylation ISO scoparone results in decreased phosphorylation of MYL1 protein CTD PMID:37449671 NCBI chr 1:66,963,454...66,987,091
Ensembl chr 1:66,963,454...66,984,563 		JBrowse link
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 multiple interactions ISO scoparone inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of NFKB1 protein] CTD PMID:16376386 NCBI chr 3:135,290,416...135,397,422
Ensembl chr 3:135,290,416...135,397,308 		JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha multiple interactions ISO scoparone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of NFKBIA protein] CTD PMID:16376386 NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432 		JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions EXP scoparone inhibits the reaction [Diethylnitrosamine promotes the reaction [[Dietary Fats co-treated with Dietary Sugars] results in increased expression of NOS2 mRNA]] CTD PMID:37436232 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 increases activity
increases expression		 ISO scoparone results in increased activity of NR1H4 protein
scoparone results in increased expression of NR1H4 mRNA		 CTD PMID:36542898 NCBI chr10:89,290,096...89,369,484
Ensembl chr10:89,290,096...89,369,447 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 increases cleavage ISO scoparone results in increased cleavage of PARP1 protein CTD PMID:37449671 NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819 		JBrowse link
G Pfkp phosphofructokinase, platelet decreases expression ISO scoparone results in decreased expression of PFKP mRNA CTD PMID:37449671 NCBI chr13:6,629,910...6,699,096
Ensembl chr13:6,629,804...6,698,813 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP scoparone inhibits the reaction [Diethylnitrosamine promotes the reaction [[Dietary Fats co-treated with Dietary Sugars] results in increased expression of PTGS2 mRNA]] CTD PMID:37436232 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978 		JBrowse link
G Rel reticuloendotheliosis oncogene multiple interactions ISO scoparone inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of REL protein] CTD PMID:16376386 NCBI chr11:23,686,847...23,720,969
Ensembl chr11:23,686,847...23,720,970 		JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions EXP
ISO		 scoparone affects the reaction [[Dietary Fats co-treated with Dietary Sugars co-treated with Diethylnitrosamine] results in increased phosphorylation of RELA protein]; scoparone inhibits the reaction [[Galactose co-treated with lipopolysaccharide, Escherichia coli O111 B4] affects the localization of and results in increased expression of RELA protein]; scoparone inhibits the reaction [Diethylnitrosamine promotes the reaction [[Dietary Fats co-treated with Dietary Sugars] results in increased expression of RELA mRNA]]; scoparone inhibits the reaction [Diethylnitrosamine promotes the reaction [[Dietary Fats co-treated with Dietary Sugars] results in increased expression of RELA protein]]
scoparone inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of RELA protein]; scoparone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of RELA protein]		 CTD PMID:16376386 PMID:23535186 PMID:37436232 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158 		JBrowse link
G Rhoa ras homolog family member A decreases expression ISO scoparone results in decreased expression of RHOA mRNA; scoparone results in decreased expression of RHOA protein CTD PMID:37449671 NCBI chr 9:108,183,359...108,215,142
Ensembl chr 9:108,183,328...108,215,133 		JBrowse link
G Rock1 Rho-associated coiled-coil containing protein kinase 1 decreases expression ISO scoparone results in decreased expression of ROCK1 mRNA; scoparone results in decreased expression of ROCK1 protein CTD PMID:37449671 NCBI chr18:10,064,401...10,182,225
Ensembl chr18:10,064,401...10,182,045 		JBrowse link
G Ticam1 TIR domain containing adaptor molecule 1 multiple interactions EXP scoparone inhibits the reaction [[Galactose co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of TICAM1 protein] CTD PMID:23535186 NCBI chr17:56,576,462...56,583,767
Ensembl chr17:56,576,319...56,583,786 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions EXP scoparone inhibits the reaction [[Galactose co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of TLR4 protein] CTD PMID:23535186 NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP scoparone inhibits the reaction [[Galactose co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of TNF protein]; scoparone inhibits the reaction [Diethylnitrosamine promotes the reaction [[Dietary Fats co-treated with Dietary Sugars] results in increased expression of TNF mRNA]]; scoparone inhibits the reaction [Diethylnitrosamine promotes the reaction [[Dietary Fats co-treated with Dietary Sugars] results in increased expression of TNF protein]] CTD PMID:23535186 PMID:37436232 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Tyr tyrosinase multiple interactions
increases expression		 EXP N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [scoparone results in increased expression of TYR protein]; scoparone results in increased expression of and results in increased activity of TYR protein
scoparone results in increased expression of TYR mRNA		 CTD PMID:17049123 NCBI chr 7:87,073,979...87,142,637
Ensembl chr 7:87,073,979...87,142,720 		JBrowse link
G Tyrp1 tyrosinase-related protein 1 increases expression EXP scoparone results in increased expression of TYRP1 mRNA CTD PMID:17049123 NCBI chr 4:80,752,360...80,769,973
Ensembl chr 4:80,752,360...80,769,956 		JBrowse link
scopoletin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaa1a acetyl-Coenzyme A acyltransferase 1A multiple interactions ISO Scopoletin inhibits the reaction [Ethanol results in decreased expression of ACAA1A mRNA] CTD PMID:26115886 NCBI chr 9:119,170,113...119,179,361
Ensembl chr 9:119,168,742...119,179,365 		JBrowse link
G Acaca acetyl-Coenzyme A carboxylase alpha multiple interactions ISO Scopoletin inhibits the reaction [Ethanol results in decreased phosphorylation of ACACA protein] CTD PMID:26115886 NCBI chr11:84,020,461...84,292,477
Ensembl chr11:84,020,498...84,292,477 		JBrowse link
G Acox1 acyl-Coenzyme A oxidase 1, palmitoyl multiple interactions ISO Scopoletin inhibits the reaction [Ethanol results in decreased expression of ACOX1 mRNA] CTD PMID:26115886 NCBI chr11:116,062,714...116,089,605
Ensembl chr11:116,062,714...116,089,871 		JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 multiple interactions ISO Scopoletin inhibits the reaction [Ethanol results in decreased expression of ACSL1 mRNA] CTD PMID:26115886 NCBI chr 8:46,924,214...46,989,088
Ensembl chr 8:46,924,074...46,989,088 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions ISO Scopoletin inhibits the reaction [Ethanol results in decreased expression of ADIPOQ mRNA]; Scopoletin inhibits the reaction [Ethanol results in decreased expression of ADIPOQ protein] CTD PMID:26115886 NCBI chr16:22,965,286...22,976,718
Ensembl chr16:22,965,286...22,976,778 		JBrowse link
G Adipor2 adiponectin receptor 2 multiple interactions
increases expression 		ISO Scopoletin inhibits the reaction [Ethanol results in decreased expression of ADIPOR2 mRNA]; Scopoletin inhibits the reaction [Ethanol results in decreased expression of ADIPOR2 protein]
scopoletin increases expression of adipor2 mRNA and protein in epididymal white adipose tissue of alcohol fed rats		 CTD
RGD		 PMID:26115886 PMID:26115886 RGD:25330099 NCBI chr 6:119,330,111...119,394,489
Ensembl chr 6:119,330,111...119,394,665 		JBrowse link
G Atf4 activating transcription factor 4 decreases expression ISO Scopoletin results in decreased expression of ATF4 mRNA CTD PMID:34979142 NCBI chr15:80,139,385...80,141,746
Ensembl chr15:80,139,385...80,141,742 		JBrowse link
G Bax BCL2-associated X protein multiple interactions ISO Scopoletin inhibits the reaction [Glucose results in increased expression of BAX protein] CTD PMID:37619648 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions ISO Scopoletin inhibits the reaction [Glucose results in decreased expression of BCL2 protein] CTD PMID:37619648 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO Scopoletin inhibits the reaction [Glucose results in increased cleavage of CASP3 protein]; Scopoletin inhibits the reaction [Glycochenodeoxycholic Acid results in increased activity of CASP3 protein]
Scopoletin inhibits the reaction [Palmitic Acid results in increased activity of CASP3 protein]		 CTD PMID:34979142 PMID:37619648 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Casp9 caspase 9 multiple interactions ISO Scopoletin inhibits the reaction [Glucose results in increased expression of CASP9 protein] CTD PMID:37619648 NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287 		JBrowse link
G Cidea cell death-inducing DNA fragmentation factor, alpha subunit-like effector A multiple interactions ISO Scopoletin inhibits the reaction [Alcohols affects the expression of CIDEA mRNA] CTD PMID:26115886 NCBI chr18:67,476,634...67,500,864
Ensembl chr18:67,476,674...67,500,855 		JBrowse link
G Cycs cytochrome c, somatic multiple interactions ISO Scopoletin inhibits the reaction [Glucose results in increased expression of CYCS protein] CTD PMID:37619648 NCBI chr 6:50,539,543...50,543,549
Ensembl chr 6:50,539,543...50,543,518 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO Scopoletin inhibits the reaction [Glycochenodeoxycholic Acid results in increased expression of DDIT3 mRNA]; Scopoletin inhibits the reaction [Palmitic Acid results in increased expression of DDIT3 mRNA] CTD PMID:34979142 NCBI chr10:127,126,662...127,132,160
Ensembl chr10:127,126,643...127,132,157
Ensembl chr10:127,126,643...127,132,157 		JBrowse link
G Fasn fatty acid synthase multiple interactions ISO Scopoletin inhibits the reaction [Ethanol results in increased expression of FASN mRNA] CTD PMID:26115886 NCBI chr11:120,696,784...120,715,992
Ensembl chr11:120,696,672...120,715,373 		JBrowse link
G Gpt glutamic pyruvic transaminase, soluble multiple interactions ISO Scopoletin inhibits the reaction [Ethanol results in increased activity of GPT protein] CTD PMID:26115886 NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886 		JBrowse link
G Hspa5 heat shock protein 5 increases expression
multiple interactions		 ISO Scopoletin results in increased expression of HSPA5 mRNA
[Glycochenodeoxycholic Acid co-treated with Scopoletin] results in increased expression of HSPA5 mRNA; [Scopoletin co-treated with Palmitic Acid] results in increased expression of HSPA5 mRNA		 CTD PMID:34979142 NCBI chr 2:34,662,102...34,666,541
Ensembl chr 2:34,661,982...34,667,559 		JBrowse link
G Il10 interleukin 10 multiple interactions ISO Scopoletin inhibits the reaction [Ethanol results in decreased expression of IL10 protein] CTD PMID:26115886 NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO Scopoletin inhibits the reaction [Ethanol results in increased expression of IL6 mRNA]; Scopoletin inhibits the reaction [Ethanol results in increased expression of IL6 protein] CTD PMID:26115886 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Lipe lipase, hormone sensitive multiple interactions ISO Scopoletin inhibits the reaction [Ethanol results in increased phosphorylation of LIPE protein] CTD PMID:26115886 NCBI chr 7:25,078,952...25,097,911
Ensembl chr 7:25,078,952...25,098,135 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions ISO Scopoletin inhibits the reaction [Glycochenodeoxycholic Acid results in increased phosphorylation of MAPK1 protein]; Scopoletin inhibits the reaction [Palmitic Acid results in increased phosphorylation of MAPK1 protein] CTD PMID:34979142 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions ISO Scopoletin inhibits the reaction [Glycochenodeoxycholic Acid results in increased phosphorylation of MAPK3 protein]; Scopoletin inhibits the reaction [Palmitic Acid results in increased phosphorylation of MAPK3 protein] CTD PMID:34979142 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO Scopoletin inhibits the reaction [Glucose results in increased phosphorylation of MAPK8 protein]; Scopoletin inhibits the reaction [Glycochenodeoxycholic Acid results in increased phosphorylation of MAPK8 protein]; Scopoletin inhibits the reaction [Palmitic Acid results in increased phosphorylation of MAPK8 protein] CTD PMID:34979142 PMID:37619648 NCBI chr14:33,099,855...33,169,213
Ensembl chr14:33,099,855...33,169,115 		JBrowse link
G Myd88 myeloid differentiation primary response gene 88 multiple interactions ISO Scopoletin inhibits the reaction [Ethanol results in increased expression of MYD88 mRNA] CTD PMID:26115886 NCBI chr 9:119,165,000...119,169,084
Ensembl chr 9:119,165,000...119,170,477 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 multiple interactions ISO Scopoletin inhibits the reaction [Glucose results in decreased expression of PARP1 protein] CTD PMID:37619648 NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819 		JBrowse link
G Pnpla2 patatin-like phospholipase domain containing 2 multiple interactions ISO Scopoletin inhibits the reaction [Ethanol results in increased expression of PNPLA2 mRNA] CTD PMID:26115886 NCBI chr 7:141,035,101...141,040,656
Ensembl chr 7:141,035,111...141,040,656 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO Scopoletin inhibits the reaction [Ethanol results in decreased expression of PPARA mRNA] CTD PMID:26115886 NCBI chr15:85,619,112...85,691,052
Ensembl chr15:85,619,184...85,687,020 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO Scopoletin inhibits the reaction [Ethanol results in increased expression of SREBF1 mRNA] CTD PMID:26115886 NCBI chr11:60,089,910...60,113,407
Ensembl chr11:60,089,915...60,113,407 		JBrowse link
G Ticam1 TIR domain containing adaptor molecule 1 multiple interactions ISO Scopoletin inhibits the reaction [Ethanol results in increased expression of TICAM1 mRNA] CTD PMID:26115886 NCBI chr17:56,576,462...56,583,767
Ensembl chr17:56,576,319...56,583,786 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO Scopoletin inhibits the reaction [Ethanol results in increased expression of TLR4 mRNA] CTD PMID:26115886 NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Scopoletin inhibits the reaction [Ethanol results in increased expression of TNF mRNA]; Scopoletin inhibits the reaction [Ethanol results in increased expression of TNF protein] CTD PMID:26115886 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase 1 family, polypeptide A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of Scopoletin CTD PMID:15802387 NCBI chr 1:88,139,681...88,147,724
Ensembl chr 1:88,139,681...88,146,719 		JBrowse link
G Ugt1a10 UDP glycosyltransferase 1 family, polypeptide A10 increases glucuronidation ISO UGT1A10 protein results in increased glucuronidation of Scopoletin CTD PMID:15802387 NCBI chr 1:87,983,133...88,147,724
Ensembl chr 1:87,983,110...88,146,726 		JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of Scopoletin CTD PMID:15802387 NCBI chr 1:88,128,333...88,147,724
Ensembl chr 1:88,128,323...88,146,719 		JBrowse link
G Ugt1a6b UDP glucuronosyltransferase 1 family, polypeptide A6B increases glucuronidation ISO UGT1A6 protein results in increased glucuronidation of Scopoletin CTD PMID:15802387 NCBI chr 1:88,030,979...88,146,720
Ensembl chr 1:88,030,974...88,146,725 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase 1 family, polypeptide A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of Scopoletin CTD PMID:15044611 PMID:15802387 NCBI chr 1:87,998,501...88,147,724
Ensembl chr 1:87,998,522...88,146,719 		JBrowse link
G Xpc xeroderma pigmentosum, complementation group C affects response to substance ISO XPC protein affects the susceptibility to Scopoletin CTD PMID:22280988 NCBI chr 6:91,466,287...91,492,870
Ensembl chr 6:91,466,287...91,492,870 		JBrowse link
scopolin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ide insulin degrading enzyme multiple interactions ISO scopolin binds to and affects the activity of IDE protein CTD PMID:23146021 NCBI chr19:37,246,140...37,341,664
Ensembl chr19:37,246,142...37,340,010 		JBrowse link
G Urod uroporphyrinogen decarboxylase multiple interactions ISO scopolin binds to and affects the activity of UROD protein CTD PMID:23209648 NCBI chr 4:116,847,161...116,851,561
Ensembl chr 4:116,847,162...116,851,610 		JBrowse link
umbelliferone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions EXP 7-hydroxycoumarin inhibits the reaction [Dietary Fats results in decreased expression of ADIPOQ protein] CTD PMID:24661945 NCBI chr16:22,965,286...22,976,718
Ensembl chr16:22,965,286...22,976,778 		JBrowse link
G Akr1c18 aldo-keto reductase family 1, member C18 multiple interactions
increases expression		 ISO 7-hydroxycoumarin inhibits the reaction [AKR1C3 mutant form results in increased susceptibility to 4-hydroxy-2-nonenal]; 7-hydroxycoumarin inhibits the reaction [AKR1C3 mutant form results in increased susceptibility to Hydrogen Peroxide]
7-hydroxycoumarin results in increased expression of AKR1C3 mRNA; 7-hydroxycoumarin results in increased expression of AKR1C3 protein		 CTD PMID:22964423 PMID:28263721 NCBI chr13:4,182,614...4,200,645
Ensembl chr13:4,182,614...4,200,653 		JBrowse link
G Akr7a5 aldo-keto reductase family 7, member A5 multiple interactions
increases expression		 ISO 7-hydroxycoumarin affects the reaction [AKR7A2 mutant form results in increased susceptibility to 4-hydroxy-2-nonenal]
7-hydroxycoumarin results in increased expression of AKR7A2 mRNA; 7-hydroxycoumarin results in increased expression of AKR7A2 protein		 CTD PMID:22964423 PMID:28263721 PMID:30849339 NCBI chr 4:139,038,005...139,046,097
Ensembl chr 4:139,038,055...139,045,737 		JBrowse link
G Atf4 activating transcription factor 4 decreases expression ISO 7-hydroxycoumarin results in decreased expression of ATF4 mRNA CTD PMID:34979142 NCBI chr15:80,139,385...80,141,746
Ensembl chr15:80,139,385...80,141,742 		JBrowse link
G Bax BCL2-associated X protein increases expression
multiple interactions		 ISO 7-hydroxycoumarin results in increased expression of BAX protein
2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [7-hydroxycoumarin inhibits the reaction [Glycerol results in increased expression of BAX protein]]; 7-hydroxycoumarin inhibits the reaction [Glycerol results in increased expression of BAX protein]		 CTD PMID:15964220 PMID:34409680 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 decreases expression
multiple interactions		 ISO 7-hydroxycoumarin results in decreased expression of BCL2 protein
2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [7-hydroxycoumarin inhibits the reaction [Glycerol results in decreased expression of BCL2 protein]]; 7-hydroxycoumarin inhibits the reaction [Glycerol results in decreased expression of BCL2 protein]		 CTD PMID:15964220 PMID:34409680 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity		 ISO 7-hydroxycoumarin inhibits the reaction [Glycochenodeoxycholic Acid results in increased activity of CASP3 protein]
7-hydroxycoumarin results in increased activity of CASP3 protein
7-hydroxycoumarin inhibits the reaction [Palmitic Acid results in increased activity of CASP3 protein]		 CTD PMID:34979142 PMID:37704181 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Cat catalase multiple interactions EXP 7-hydroxycoumarin inhibits the reaction [Dietary Fats results in decreased activity of CAT protein] CTD PMID:24661945 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505 		JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO 7-hydroxycoumarin results in decreased expression of CCND1 protein CTD PMID:11679177 NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 increases expression
multiple interactions		 ISO 7-hydroxycoumarin results in increased expression of CREB1 mRNA
7-hydroxycoumarin inhibits the reaction [Cisplatin results in decreased expression of CREB1 mRNA]		 CTD PMID:33522649 NCBI chr 1:64,571,963...64,643,707
Ensembl chr 1:64,571,804...64,643,707 		JBrowse link
G Cygb cytoglobin increases expression
multiple interactions		 ISO 7-hydroxycoumarin results in increased expression of CYGB protein
7-hydroxycoumarin inhibits the reaction [Cisplatin results in decreased expression of CYGB protein]		 CTD PMID:33522649 NCBI chr11:116,536,421...116,544,887
Ensembl chr11:116,536,421...116,545,139 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO [CYP1A2 protein results in increased metabolism of coumarin] which results in increased abundance of 7-hydroxycoumarin CTD PMID:34334558 NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986 		JBrowse link
G Cyp2a5 cytochrome P450, family 2, subfamily a, polypeptide 5 multiple interactions
increases chemical synthesis		 ISO [CYP2A6 protein results in increased metabolism of coumarin] which results in increased chemical synthesis of 7-hydroxycoumarin; Methoxsalen inhibits the reaction [CYP2A6 protein results in increased chemical synthesis of 7-hydroxycoumarin]; nitrosobenzylmethylamine inhibits the reaction [CYP2A6 protein results in increased chemical synthesis of 7-hydroxycoumarin]; Tranylcypromine inhibits the reaction [CYP2A6 protein results in increased chemical synthesis of 7-hydroxycoumarin] CTD PMID:10616189 PMID:11376561 PMID:11393269 PMID:11927840 PMID:12401345 More... NCBI chr 7:26,534,764...26,542,689
Ensembl chr 7:26,534,730...26,542,973 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions EXP 7-hydroxycoumarin inhibits the reaction [Dietary Fats results in increased activity of CYP2E1 protein] CTD PMID:24661945 NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO 7-hydroxycoumarin inhibits the reaction [Glycochenodeoxycholic Acid results in increased expression of DDIT3 mRNA] CTD PMID:34979142 NCBI chr10:127,126,662...127,132,160
Ensembl chr10:127,126,643...127,132,157
Ensembl chr10:127,126,643...127,132,157 		JBrowse link
G Foxo3 forkhead box O3 multiple interactions ISO 7-hydroxycoumarin inhibits the reaction [Cisplatin results in increased expression of FOXO3 mRNA] CTD PMID:33522649 NCBI chr10:42,057,841...42,152,691
Ensembl chr10:42,057,837...42,152,751 		JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 multiple interactions ISO 7-hydroxycoumarin inhibits the reaction [Cisplatin results in increased expression of HAVCR1 protein] CTD PMID:33522649 NCBI chr11:46,630,644...46,670,405
Ensembl chr11:46,625,907...46,670,405 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-Coenzyme A reductase multiple interactions ISO 7-hydroxycoumarin inhibits the reaction [Isoproterenol results in increased activity of HMGCR protein] CTD PMID:26995004 NCBI chr13:96,785,470...96,807,444
Ensembl chr13:96,785,475...96,807,444 		JBrowse link
G Hspa5 heat shock protein 5 increases expression
multiple interactions		 ISO 7-hydroxycoumarin results in increased expression of HSPA5 mRNA
[7-hydroxycoumarin co-treated with Palmitic Acid] results in increased expression of HSPA5 mRNA		 CTD PMID:34979142 NCBI chr 2:34,662,102...34,666,541
Ensembl chr 2:34,661,982...34,667,559 		JBrowse link
G Ikbkb inhibitor of kappaB kinase beta multiple interactions ISO 7-hydroxycoumarin inhibits the reaction [Cisplatin results in increased expression of IKBKB protein] CTD PMID:33522649 NCBI chr 8:23,149,228...23,196,605
Ensembl chr 8:23,149,228...23,196,605 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO 7-hydroxycoumarin inhibits the reaction [Cisplatin results in increased expression of IL1B protein] CTD PMID:33522649 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO 7-hydroxycoumarin inhibits the reaction [Streptozocin results in increased expression of IL6 protein] CTD PMID:36650709 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Ins1 insulin I multiple interactions ISO 7-hydroxycoumarin inhibits the reaction [Streptozocin results in decreased expression of INS1 protein] CTD PMID:36650709 NCBI chr19:52,252,735...52,253,453
Ensembl chr19:52,252,735...52,253,914 		JBrowse link
G Jak2 Janus kinase 2 multiple interactions ISO 7-hydroxycoumarin inhibits the reaction [Streptozocin results in increased expression of JAK2 mRNA]; 7-hydroxycoumarin inhibits the reaction [Streptozocin results in increased expression of JAK2 protein] CTD PMID:36650709 NCBI chr19:29,229,006...29,290,495
Ensembl chr19:29,229,228...29,290,480 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions ISO 7-hydroxycoumarin inhibits the reaction [Glycochenodeoxycholic Acid results in increased phosphorylation of MAPK1 protein]; 7-hydroxycoumarin inhibits the reaction [Palmitic Acid results in increased phosphorylation of MAPK1 protein] CTD PMID:34979142 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions ISO 7-hydroxycoumarin inhibits the reaction [Glycochenodeoxycholic Acid results in increased phosphorylation of MAPK3 protein]; 7-hydroxycoumarin inhibits the reaction [Palmitic Acid results in increased phosphorylation of MAPK3 protein] CTD PMID:34979142 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO 7-hydroxycoumarin inhibits the reaction [Glycochenodeoxycholic Acid results in increased phosphorylation of MAPK8 protein]; 7-hydroxycoumarin inhibits the reaction [Palmitic Acid results in increased phosphorylation of MAPK8 protein] CTD PMID:34979142 NCBI chr14:33,099,855...33,169,213
Ensembl chr14:33,099,855...33,169,115 		JBrowse link
G Mpo myeloperoxidase multiple interactions
increases oxidation		 ISO [4-aminobenzhydrazide results in decreased activity of MPO protein] which affects the susceptibility to 7-hydroxycoumarin
MPO protein results in increased oxidation of 7-hydroxycoumarin		 CTD PMID:23994743 NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239 		JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 increases expression
multiple interactions		 ISO 7-hydroxycoumarin results in increased expression of NFE2L2 mRNA
7-hydroxycoumarin inhibits the reaction [Cisplatin results in decreased expression of NFE2L2 mRNA]; 7-hydroxycoumarin inhibits the reaction [Cisplatin results in decreased expression of NFE2L2 protein]
7-hydroxycoumarin results in increased expression of NFE2L2 mRNA; 7-hydroxycoumarin results in increased expression of NFE2L2 protein
7-hydroxycoumarin results in increased expression of and affects the localization of NFE2L2 protein		 CTD PMID:28263721 PMID:33522649 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985 		JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha decreases expression
multiple interactions		 ISO 7-hydroxycoumarin results in decreased expression of NFKBIA protein
7-hydroxycoumarin inhibits the reaction [Cisplatin results in decreased expression of NFKBIA protein]		 CTD PMID:33522649 NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432 		JBrowse link
G Pparg peroxisome proliferator activated receptor gamma multiple interactions
increases expression		 ISO 7-hydroxycoumarin inhibits the reaction [Cisplatin results in decreased expression of PPARG mRNA]
7-hydroxycoumarin results in increased expression of PPARG mRNA		 CTD PMID:33522649 NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360 		JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions ISO 7-hydroxycoumarin inhibits the reaction [Cisplatin results in increased expression of RELA protein] CTD PMID:33522649 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158 		JBrowse link
G Sirt1 sirtuin 1 multiple interactions
increases expression		 ISO 7-hydroxycoumarin inhibits the reaction [Cisplatin results in decreased expression of SIRT1 mRNA]
7-hydroxycoumarin results in increased expression of SIRT1 mRNA		 CTD PMID:33522649 NCBI chr10:63,154,784...63,174,814
Ensembl chr10:63,154,784...63,217,483 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO 7-hydroxycoumarin inhibits the reaction [Streptozocin results in increased expression of STAT3 mRNA]; 7-hydroxycoumarin inhibits the reaction [Streptozocin results in increased expression of STAT3 protein] CTD PMID:36650709 NCBI chr11:100,777,632...100,830,447
Ensembl chr11:100,775,924...100,830,366 		JBrowse link
G Sult5a1 sulfotransferase family 5A, member 1 increases sulfation EXP SULT1A1 protein results in increased sulfation of 7-hydroxycoumarin CTD PMID:11181495 NCBI chr 8:123,869,582...123,885,170
Ensembl chr 8:123,866,931...123,885,054 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO 7-hydroxycoumarin inhibits the reaction [Streptozocin results in increased expression of TGFB1 mRNA]; 7-hydroxycoumarin inhibits the reaction [Streptozocin results in increased expression of TGFB1 protein] CTD PMID:36650709 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO 7-hydroxycoumarin inhibits the reaction [Cisplatin results in increased expression of TNF protein]; 7-hydroxycoumarin inhibits the reaction [Streptozocin results in increased expression of TNF protein] CTD PMID:33522649 PMID:36650709 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Ugt1a6b UDP glucuronosyltransferase 1 family, polypeptide A6B affects metabolic processing
increases metabolic processing		 ISO UGT1A6 gene polymorphism affects the metabolism of 7-hydroxycoumarin
UGT1A6 protein results in increased metabolism of 7-hydroxycoumarin		 CTD PMID:9429234 NCBI chr 1:88,030,979...88,146,720
Ensembl chr 1:88,030,974...88,146,725 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase 1 family, polypeptide A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of 7-hydroxycoumarin CTD PMID:15044611 NCBI chr 1:87,998,501...88,147,724
Ensembl chr 1:87,998,522...88,146,719 		JBrowse link
warfarin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B member 1A affects response to substance
increases expression		 ISO
EXP		 ABCB1 polymorphism affects the susceptibility to Warfarin
Warfarin results in increased expression of ABCB1A mRNA		 CTD PMID:24092646 PMID:25312789 PMID:27397090 NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575 		JBrowse link
G Abcc6 ATP-binding cassette, sub-family C member 6 multiple interactions
increases response to substance		 EXP [Magnesium deficiency co-treated with Phosphates] promotes the reaction [ABCC6 gene mutant form results in increased susceptibility to Warfarin] CTD PMID:23415960 NCBI chr 7:45,625,804...45,679,915
Ensembl chr 7:45,616,979...45,679,726 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 (Junior blood group) affects response to substance ISO ABCG2 SNP affects the susceptibility to Warfarin CTD PMID:25300812 NCBI chr 6:58,561,476...58,669,436
Ensembl chr 6:58,561,508...58,672,661 		JBrowse link
G Acta2 actin alpha 2, smooth muscle, aorta multiple interactions ISO [Warfarin co-treated with Vitamin K co-treated with Quercetin] results in increased expression of ACTA2 mRNA CTD PMID:23117658 NCBI chr19:34,217,736...34,232,985
Ensembl chr19:34,218,490...34,232,990 		JBrowse link
G Actb actin, beta increases expression
decreases expression		 EXP Warfarin results in increased expression of ACTB mRNA
Warfarin results in decreased expression of ACTB mRNA		 CTD PMID:20493250 NCBI chr 5:142,888,870...142,892,509
Ensembl chr 5:142,888,870...142,892,509 		JBrowse link
G Actr3 ARP3 actin-related protein 3 increases expression EXP Warfarin results in increased expression of ACTR3 mRNA CTD PMID:20493250 NCBI chr 1:125,320,642...125,363,464
Ensembl chr 1:125,320,642...125,363,464 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing increases expression
multiple interactions		 ISO Warfarin results in increased expression of ADIPOQ protein
Warfarin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of ADIPOQ protein]		 CTD PMID:27488359 NCBI chr16:22,965,286...22,976,718
Ensembl chr16:22,965,286...22,976,778 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a multiple interactions ISO epigallocatechin gallate promotes the reaction [Warfarin inhibits the reaction [Hydrogen Peroxide results in increased expression of AGTR1 mRNA]]; epigallocatechin gallate promotes the reaction [Warfarin inhibits the reaction [Hydrogen Peroxide results in increased expression of AGTR1 protein]]; Warfarin inhibits the reaction [Hydrogen Peroxide results in increased expression of AGTR1 mRNA]; Warfarin inhibits the reaction [Hydrogen Peroxide results in increased expression of AGTR1 protein] CTD PMID:36162953 NCBI chr13:30,520,339...30,566,850
Ensembl chr13:30,520,424...30,566,850 		JBrowse link
G Ahcy S-adenosylhomocysteine hydrolase decreases expression EXP Warfarin results in decreased expression of AHCY mRNA CTD PMID:20493250 NCBI chr 2:154,901,230...154,916,417
Ensembl chr 2:154,901,230...154,916,417 		JBrowse link
G Akt1 thymoma viral proto-oncogene 1 multiple interactions ISO 6-N,N-diethyl-beta,gamma-dibromomethylene-D-ATP inhibits the reaction [[Warfarin co-treated with Phosphates] results in decreased phosphorylation of AKT1 protein]; [Warfarin co-treated with Phosphates] results in decreased phosphorylation of AKT1 protein; [Warfarin co-treated with Vitamin K 1] results in decreased phosphorylation of AKT1 protein; Vitamin K 2 inhibits the reaction [[Warfarin co-treated with Vitamin K 1] results in decreased phosphorylation of AKT1 protein] CTD PMID:22659116 PMID:27212383 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318 		JBrowse link
G Alb albumin multiple interactions
affects binding
decreases expression		 ISO [Warfarin binds to ALB protein] inhibits the reaction [copper (II) diacetyl-di(N(4)-methylthiosemicarbazone) binds to ALB protein]; [Warfarin binds to ALB protein] inhibits the reaction [copper pyruvaldehyde bis(N(4)-methylthiosemicarbazone) complex binds to ALB protein]; Aspirin inhibits the reaction [Warfarin binds to ALB protein]; prodan inhibits the reaction [Warfarin binds to ALB protein]; Pyruvaldehyde inhibits the reaction [Warfarin binds to ALB protein]
Warfarin results in decreased expression of ALB protein		 CTD PMID:10506189 PMID:12044178 PMID:18937368 PMID:19596536 PMID:20934417 More... NCBI chr 5:90,608,729...90,624,461
Ensembl chr 5:90,608,756...90,624,461 		JBrowse link
G Alox5ap arachidonate 5-lipoxygenase activating protein increases expression ISO Warfarin results in increased expression of ALOX5AP mRNA CTD PMID:16698924 NCBI chr 5:149,201,814...149,224,963
Ensembl chr 5:149,201,577...149,224,963 		JBrowse link
G Alpl alkaline phosphatase, liver/bone/kidney multiple interactions EXP Warfarin inhibits the reaction [BMP2 protein results in increased activity of ALPL protein]; Warfarin inhibits the reaction [BMP2 protein results in increased expression of ALPL mRNA]; Warfarin inhibits the reaction [RUNX2 protein results in increased expression of ALPL mRNA] CTD PMID:21910061 NCBI chr 4:137,469,042...137,523,695
Ensembl chr 4:137,469,044...137,523,695 		JBrowse link
G Anxa4 annexin A4 decreases expression EXP Warfarin results in decreased expression of ANXA4 mRNA CTD PMID:20493250 NCBI chr 6:86,713,822...86,770,616
Ensembl chr 6:86,713,822...86,770,566 		JBrowse link
G Anxa5 annexin A5 decreases expression EXP Warfarin results in decreased expression of ANXA5 mRNA CTD PMID:20493250 NCBI chr 3:36,503,072...36,530,036
Ensembl chr 3:36,503,072...36,530,043 		JBrowse link
G Apoa1 apolipoprotein A-I affects response to substance ISO APOA1 gene SNP affects the susceptibility to Warfarin CTD PMID:32282500 NCBI chr 9:46,139,928...46,141,767
Ensembl chr 9:46,139,878...46,141,764 		JBrowse link
G Apob apolipoprotein B affects response to substance ISO APOB gene SNP affects the susceptibility to Warfarin CTD PMID:31186542 NCBI chr12:8,027,629...8,066,839
Ensembl chr12:8,027,648...8,066,835 		JBrowse link
G Apoe apolipoprotein E increases response to substance
affects response to substance		 EXP
ISO		 APOE gene mutant form results in increased susceptibility to Warfarin
APOE gene mutant form affects the susceptibility to Warfarin; APOE gene polymorphism affects the susceptibility to Warfarin; APOE gene SNP affects the susceptibility to Warfarin; APOE polymorphism affects the susceptibility to Warfarin; APOE protein affects the susceptibility to Warfarin; APOE SNP affects the susceptibility to Warfarin		 CTD PMID:15952022 PMID:16847429 PMID:17048007 PMID:17325732 PMID:21228733 More... NCBI chr 7:19,430,169...19,434,326
Ensembl chr 7:19,430,034...19,433,113 		JBrowse link
G Arhgdia Rho GDP dissociation inhibitor alpha increases expression EXP Warfarin results in increased expression of ARHGDIA mRNA CTD PMID:20493250 NCBI chr11:120,468,925...120,472,450
Ensembl chr11:120,468,930...120,472,450 		JBrowse link
G Asph aspartate-beta-hydroxylase affects response to substance ISO ASPH gene SNP affects the susceptibility to Warfarin CTD PMID:27488176 NCBI chr 4:9,449,085...9,669,344
Ensembl chr 4:9,448,069...9,669,344 		JBrowse link
G Axin2 axin 2 multiple interactions
increases expression		 ISO [Warfarin co-treated with Vitamin K] results in increased expression of AXIN2 mRNA; Quercetin inhibits the reaction [[Warfarin co-treated with Vitamin K] results in increased expression of AXIN2 mRNA]; Quercetin inhibits the reaction [Warfarin results in increased expression of AXIN2 mRNA] CTD PMID:23117658 NCBI chr11:108,808,687...108,841,609
Ensembl chr11:108,811,175...108,841,609 		JBrowse link
G Axl AXL receptor tyrosine kinase multiple interactions
increases response to substance
decreases expression
decreases phosphorylation		 ISO [Warfarin co-treated with Vitamin K 1] results in decreased expression of AXL protein; Vitamin K 2 inhibits the reaction [[Warfarin co-treated with Vitamin K 1] results in decreased expression of AXL protein]; Warfarin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of AXL protein]
AXL protein results in increased susceptibility to Warfarin
Warfarin results in decreased expression of AXL protein; Warfarin results in decreased expression of AXL protein modified form
Warfarin results in decreased phosphorylation of AXL protein
AXL protein promotes the reaction [Warfarin results in increased susceptibility to Gemcitabine]; Vitamin K inhibits the reaction [Warfarin results in decreased expression of AXL protein modified form]; Warfarin inhibits the reaction [GAS6 protein results in increased activity of AXL protein]		 CTD PMID:15123721 PMID:26206560 PMID:27212383 NCBI chr 7:25,455,925...25,488,502
Ensembl chr 7:25,456,698...25,488,130 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions ISO [Warfarin co-treated with Vitamin K 1] results in decreased expression of BCL2 protein; Vitamin K 2 inhibits the reaction [[Warfarin co-treated with Vitamin K 1] results in decreased expression of BCL2 protein] CTD PMID:27212383 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Bglap bone gamma carboxyglutamate protein multiple interactions
increases expression		 EXP
ISO		 Warfarin inhibits the reaction [BMP2 protein results in increased activity of BGLAP protein]; Warfarin inhibits the reaction [BMP2 protein results in increased expression of BGLAP mRNA]; Warfarin inhibits the reaction [menaquinone 7 results in increased carboxylation of BGLAP protein]; Warfarin inhibits the reaction [menatetrenone results in increased carboxylation of BGLAP protein]; Warfarin inhibits the reaction [RUNX2 protein results in increased expression of BGLAP mRNA]; Warfarin inhibits the reaction [Vitamin K 1 results in increased carboxylation of BGLAP protein]
Warfarin results in increased expression of BGLAP mRNA; Warfarin results in increased expression of BGLAP protein modified form
[Warfarin co-treated with Vitamin K] results in increased expression of BGLAP mRNA; Quercetin inhibits the reaction [[Warfarin co-treated with Vitamin K] results in increased expression of BGLAP mRNA]; Quercetin inhibits the reaction [Warfarin results in increased expression of BGLAP mRNA]; Warfarin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of BGLAP protein modified form]		 CTD PMID:21910061 PMID:23117658 PMID:23223575 PMID:27488359 PMID:31173816 NCBI chr 3:88,290,802...88,291,773
Ensembl chr 3:88,290,808...88,291,771 		JBrowse link
G Bmp2 bone morphogenetic protein 2 multiple interactions EXP
ISO		 Warfarin inhibits the reaction [BMP2 protein results in increased activity of ALPL protein]; Warfarin inhibits the reaction [BMP2 protein results in increased activity of BGLAP protein]; Warfarin inhibits the reaction [BMP2 protein results in increased activity of RUNX2 protein]; Warfarin inhibits the reaction [BMP2 protein results in increased expression of ALPL mRNA]; Warfarin inhibits the reaction [BMP2 protein results in increased expression of BGLAP mRNA]; Warfarin inhibits the reaction [BMP2 protein results in increased expression of COL1A1 mRNA]; Warfarin inhibits the reaction [BMP2 protein results in increased expression of SP7 mRNA]
[Warfarin co-treated with Vitamin K 1] affects the expression of BMP2 mRNA; [Warfarin co-treated with Vitamin K 1] affects the expression of BMP2 protein; Losartan affects the reaction [[Warfarin co-treated with Vitamin K 1] affects the expression of BMP2 mRNA]; Losartan affects the reaction [[Warfarin co-treated with Vitamin K 1] affects the expression of BMP2 protein]		 CTD PMID:21910061 PMID:27412937 NCBI chr 2:133,394,079...133,404,816
Ensembl chr 2:133,394,079...133,404,805 		JBrowse link
G C1qbp complement component 1, q subcomponent binding protein increases expression EXP Warfarin results in increased expression of C1QBP mRNA CTD PMID:20493250 NCBI chr11:70,868,672...70,873,852
Ensembl chr11:70,868,662...70,873,852 		JBrowse link
G Calr calreticulin increases expression EXP Warfarin results in increased expression of CALR mRNA CTD PMID:20493250 NCBI chr 8:85,568,717...85,573,560
Ensembl chr 8:85,568,479...85,573,563 		JBrowse link
G Calu calumenin decreases response to substance
affects response to substance		 ISO CALU protein results in decreased susceptibility to Warfarin
CALU gene SNP affects the susceptibility to Warfarin; CALU polymorphism affects the susceptibility to Warfarin		 CTD PMID:11641264 PMID:20200517 PMID:27632229 NCBI chr 6:29,348,105...29,376,674
Ensembl chr 6:29,348,068...29,377,109 		JBrowse link
G Casp3 caspase 3 decreases expression
increases expression
multiple interactions		 EXP
ISO		 Warfarin results in decreased expression of CASP3 mRNA
Warfarin results in increased expression of CASP3 protein modified form
[Warfarin co-treated with Vitamin K 1] results in increased cleavage of CASP3 protein
Warfarin results in increased expression of CASP3 mRNA		 CTD PMID:19815060 PMID:20493250 PMID:23990204 PMID:26206560 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Cat catalase increases activity ISO Warfarin results in increased activity of CAT protein CTD PMID:22342526 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505 		JBrowse link
G Ccnd1 cyclin D1 increases expression
multiple interactions		 ISO Warfarin results in increased expression of CCND1 mRNA
[Warfarin co-treated with Vitamin K] results in increased expression of CCND1 mRNA; Quercetin inhibits the reaction [[Warfarin co-treated with Vitamin K] results in increased expression of CCND1 mRNA]; Quercetin inhibits the reaction [Warfarin results in increased expression of CCND1 mRNA]		 CTD PMID:23117658 NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662 		JBrowse link
G Cct5 chaperonin containing TCP1 subunit 5 increases expression EXP Warfarin results in increased expression of CCT5 mRNA CTD PMID:20493250 NCBI chr15:31,590,946...31,601,992
Ensembl chr15:31,590,946...31,601,950 		JBrowse link
G Cct6a chaperonin containing TCP1 subunit 6A increases expression EXP Warfarin results in increased expression of CCT6A mRNA CTD PMID:20493250 NCBI chr 5:129,864,420...129,875,284
Ensembl chr 5:129,864,062...129,875,212 		JBrowse link
G Cct8 chaperonin containing TCP1 subunit 8 decreases expression EXP Warfarin results in decreased expression of CCT8 mRNA CTD PMID:20493250 NCBI chr16:87,280,213...87,292,757
Ensembl chr16:87,280,214...87,292,761 		JBrowse link
G Cdc42 cell division cycle 42 decreases expression EXP Warfarin results in decreased expression of CDC42 mRNA CTD PMID:20493250 NCBI chr 4:137,047,011...137,085,007
Ensembl chr 4:137,047,007...137,085,031 		JBrowse link
G Cdh1 cadherin 1 increases expression ISO Warfarin results in increased expression of CDH1 protein CTD PMID:26206560 NCBI chr 8:107,329,982...107,396,879
Ensembl chr 8:107,329,983...107,396,878 		JBrowse link
G Clic1 chloride intracellular channel 1 decreases expression EXP Warfarin results in decreased expression of CLIC1 mRNA CTD PMID:20493250 NCBI chr17:35,269,219...35,277,695
Ensembl chr17:35,268,942...35,277,725 		JBrowse link
G Cnn1 calponin 1 multiple interactions ISO [Warfarin co-treated with Vitamin K co-treated with Quercetin] results in increased expression of CNN1 mRNA CTD PMID:23117658 NCBI chr 9:22,010,501...22,020,517
Ensembl chr 9:22,010,512...22,020,926 		JBrowse link
G Col1a1 collagen, type I, alpha 1 multiple interactions
increases expression		 EXP
ISO		 Warfarin inhibits the reaction [BMP2 protein results in increased expression of COL1A1 mRNA]
[Warfarin co-treated with Vitamin K] results in increased expression of COL1A1 mRNA; Quercetin inhibits the reaction [[Warfarin co-treated with Vitamin K] results in increased expression of COL1A1 mRNA]; Quercetin inhibits the reaction [Warfarin results in increased expression of COL1A1 mRNA]		 CTD PMID:21910061 PMID:23117658 PMID:23223575 NCBI chr11:94,827,050...94,843,868
Ensembl chr11:94,827,050...94,843,868 		JBrowse link
G Cox15 cytochrome c oxidase assembly protein 15 affects response to substance ISO COX15 gene affects the susceptibility to Warfarin CTD PMID:28686080 NCBI chr19:43,721,693...43,741,439
Ensembl chr19:43,721,693...43,741,439 		JBrowse link
G Cox5a cytochrome c oxidase subunit 5A increases expression EXP Warfarin results in increased expression of COX5A mRNA CTD PMID:20493250 NCBI chr 9:57,423,012...57,439,710
Ensembl chr 9:57,428,557...57,439,709 		JBrowse link
G Crk v-crk avian sarcoma virus CT10 oncogene homolog increases expression EXP Warfarin results in increased expression of CRK mRNA CTD PMID:20493250 NCBI chr11:75,570,020...75,599,254
Ensembl chr11:75,570,085...75,597,734 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
affects response to substance		 ISO Warfarin results in decreased expression of and affects the localization of CTNNB1 protein
CTNNB1 protein affects the susceptibility to Warfarin
Quercetin inhibits the reaction [Warfarin results in increased expression of and affects the localization of CTNNB1 protein]; Warfarin results in increased expression of and affects the localization of CTNNB1 protein		 CTD PMID:23117658 PMID:23223575 PMID:26206560 NCBI chr 9:120,762,466...120,789,573
Ensembl chr 9:120,758,282...120,789,573 		JBrowse link
G Cxcl15 C-X-C motif chemokine ligand 15 multiple interactions ISO [Warfarin co-treated with lipopolysaccharide, E. coli O26-B6] results in decreased expression of CXCL8 mRNA CTD PMID:29594315 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity EXP Warfarin results in decreased activity of CYP1A1 protein CTD PMID:18420780 NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 affects metabolic processing
affects response to substance		 ISO CYP1A2 protein affects the metabolism of Warfarin
CYP1A2 SNP affects the susceptibility to Warfarin		 CTD PMID:14676821 PMID:15280511 PMID:28079798 NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986 		JBrowse link
G Cyp2a4 cytochrome P450, family 2, subfamily a, polypeptide 4 decreases activity EXP Warfarin results in decreased activity of CYP2A4 protein CTD PMID:18420780 NCBI chr 7:26,006,617...26,014,513
Ensembl chr 7:26,006,594...26,014,513 		JBrowse link
G Cyp2b10 cytochrome P450, family 2, subfamily b, polypeptide 10 decreases activity EXP Warfarin results in decreased activity of CYP2B10 protein CTD PMID:18420780 NCBI chr 7:25,597,083...25,626,049
Ensembl chr 7:25,597,045...25,626,049 		JBrowse link
G Cyp2c29 cytochrome P450, family 2, subfamily c, polypeptide 29 decreases activity
affects response to substance		 EXP
ISO		 Warfarin results in decreased activity of CYP2C29 protein
CYP2C8 polymorphism affects the susceptibility to Warfarin		 CTD PMID:18420780 PMID:34382722 NCBI chr19:39,275,541...39,319,157
Ensembl chr19:39,257,849...39,319,157 		JBrowse link
G Cyp2c38 cytochrome P450, family 2, subfamily c, polypeptide 38 affects response to substance
affects metabolic processing
multiple interactions		 ISO CYP2C19 gene polymorphism affects the susceptibility to Warfarin; CYP2C19 polymorphism affects the susceptibility to Warfarin; CYP2C19 protein affects the susceptibility to Warfarin
CYP2C19 protein affects the metabolism of Warfarin
CYP2C19 gene polymorphism affects the metabolism of and affects the susceptibility to Warfarin; Omeprazole affects the reaction [CYP2C19 protein affects the metabolism of Warfarin]		 CTD PMID:18520598 PMID:19752777 PMID:25652102 PMID:27356304 NCBI chr19:39,379,109...39,451,519
Ensembl chr19:39,378,000...39,451,519 		JBrowse link
G Cyp2c52-ps cytochrome P450, family 2, subfamily c, polypeptide 52, pseudogene increases metabolic processing
affects response to substance		 ISO CYP2C11 protein results in increased metabolism of Warfarin
CYP2C18 gene polymorphism affects the susceptibility to Warfarin; CYP2C18 protein affects the susceptibility to Warfarin		 CTD PMID:19752777 PMID:30724651 NCBI chr19:38,965,106...38,992,071
Ensembl chr19:38,965,091...38,991,733 		JBrowse link
G Cyp2c65 cytochrome P450, family 2, subfamily c, polypeptide 65 affects metabolic processing
increases hydroxylation
affects abundance
decreases activity
multiple interactions
increases metabolic processing
affects response to substance
increases hydrolysis
affects hydroxylation
decreases response to substance
decreases metabolic processing
decreases hydroxylation
increases response to substance
affects hydrolysis		 ISO CYP2C9 enhancer polymorphism affects the metabolism of Warfarin; CYP2C9 gene affects the metabolism of Warfarin; CYP2C9 gene polymorphism affects the metabolism of Warfarin; CYP2C9 protein affects the metabolism of Warfarin
CYP2C9 protein results in increased hydroxylation of Warfarin
CYP2C9 gene polymorphism affects the abundance of Warfarin
Warfarin results in decreased activity of CYP2C9 protein
10-hydroxywarfarin inhibits the reaction [[CYP2C9 protein results in increased hydroxylation of Warfarin] which results in increased chemical synthesis of 7-hydroxywarfarin]; 4'-hydroxywarfarin inhibits the reaction [[CYP2C9 protein results in increased hydroxylation of Warfarin] which results in increased chemical synthesis of 7-hydroxywarfarin]; 6-hydroxywarfarin inhibits the reaction [[CYP2C9 protein results in increased hydroxylation of Warfarin] which results in increased chemical synthesis of 7-hydroxywarfarin]; 7-hydroxywarfarin inhibits the reaction [[CYP2C9 protein results in increased hydroxylation of Warfarin] which results in increased chemical synthesis of 6-hydroxywarfarin]; 8-hydroxywarfarin inhibits the reaction [[CYP2C9 protein results in increased hydroxylation of Warfarin] which results in increased chemical synthesis of 7-hydroxywarfarin]; [[Ticrynafen results in decreased activity of CYP2C9 protein] which affects the metabolism of Warfarin analog] which affects the abundance of 7-hydroxywarfarin; [CYP2C9 gene polymorphism affects the metabolism of Warfarin] which affects the abundance of 10-hydroxywarfarin; [CYP2C9 gene polymorphism affects the metabolism of Warfarin] which affects the abundance of 4'-hydroxywarfarin; [CYP2C9 gene polymorphism affects the metabolism of Warfarin] which affects the abundance of 6-hydroxywarfarin; [CYP2C9 gene polymorphism affects the metabolism of Warfarin] which affects the abundance of 7-hydroxywarfarin; [CYP2C9 protein results in increased hydroxylation of Warfarin] which results in increased chemical synthesis of 6-hydroxywarfarin; [CYP2C9 protein results in increased hydroxylation of Warfarin] which results in increased chemical synthesis of 7-hydroxywarfarin; [CYP2C9 protein results in increased metabolism of Warfarin] which results in increased chemical synthesis of 6-hydroxywarfarin; [CYP2C9 protein results in increased metabolism of Warfarin] which results in increased chemical synthesis of 7-hydroxywarfarin; [Ticrynafen results in decreased activity of CYP2C9 protein] which affects the metabolism of Warfarin analog; [Warfarin binds to and results in increased activity of NR1I2 protein] which results in increased expression of CYP2C9 mRNA; Benzbromarone inhibits the reaction [CYP2C9 protein affects the metabolism of Warfarin]; CYP2C9 gene polymorphism affects the reaction [Vitamin K affects the susceptibility to Warfarin]; CYP2C9 gene polymorphism affects the susceptibility to and affects the metabolism of Warfarin; Simvastatin affects the reaction [CYP2C9 polymorphism affects the susceptibility to Warfarin]; Warfarin inhibits the reaction [CYP2C9 protein affects the metabolism of Diclofenac]
CYP2C9 affects the susceptibility to Warfarin; CYP2C9 alternative form affects the susceptibility to Warfarin; CYP2C9 gene affects the susceptibility to Warfarin; CYP2C9 gene mutant form affects the susceptibility to Warfarin; CYP2C9 gene polymorphism affects the susceptibility to Warfarin; CYP2C9 gene SNP affects the susceptibility to Warfarin; CYP2C9 polymorphism affects the susceptibility to Warfarin; CYP2C9 protein affects the susceptibility to Warfarin; CYP2C9 protein polymorphism affects the susceptibility to Warfarin; CYP2C9 SNP affects the susceptibility to Warfarin; CYP2C9 SNP affects the susceptibility to Warfarin analog
CYP2C9 protein results in increased hydrolysis of Warfarin
CYP2C9 protein affects the hydroxylation of Warfarin
CYP2C9 gene polymorphism results in decreased susceptibility to Warfarin
CYP2C9 gene polymorphism results in decreased metabolism of Warfarin
CYP2C9 gene polymorphism results in decreased hydroxylation of Warfarin
CYP2C9 gene mutant form results in increased susceptibility to Warfarin; CYP2C9 gene polymorphism results in increased susceptibility to Warfarin; CYP2C9 protein results in increased susceptibility to Warfarin; CYP2C9 results in increased susceptibility to Warfarin
CYP2C9 gene polymorphism affects the hydrolysis of Warfarin		 CTD PMID:9241660 PMID:9522436 PMID:9698079 PMID:10613612 PMID:11127854 More... NCBI chr19:39,049,450...39,082,392
Ensembl chr19:39,049,459...39,082,388 		JBrowse link
G Cyp2d22 cytochrome P450, family 2, subfamily d, polypeptide 22 decreases activity ISO Warfarin results in decreased activity of CYP2D6 protein CTD PMID:18420780 NCBI chr15:82,254,728...82,264,461
Ensembl chr15:82,254,728...82,264,461 		JBrowse link
G Cyp3a13 cytochrome P450, family 3, subfamily a, polypeptide 13 affects response to substance ISO CYP3A5 gene polymorphism affects the susceptibility to Warfarin; CYP3A5 polymorphism affects the susceptibility to Warfarin; CYP3A5 protein affects the susceptibility to Warfarin CTD PMID:19752777 PMID:34382722 NCBI chr 5:137,891,195...137,923,872
Ensembl chr 5:137,891,194...137,919,881 		JBrowse link
G Dctn2 dynactin 2 decreases expression EXP Warfarin results in decreased expression of DCTN2 mRNA CTD PMID:20493250 NCBI chr10:127,102,131...127,117,828
Ensembl chr10:127,102,237...127,117,819 		JBrowse link
G Ddhd1 DDHD domain containing 1 affects response to substance ISO DDHD1 gene SNP affects the susceptibility to Warfarin CTD PMID:27488176 NCBI chr14:45,830,628...45,895,600
Ensembl chr14:45,825,924...45,895,600 		JBrowse link
G Ddt D-dopachrome tautomerase decreases expression EXP Warfarin results in decreased expression of DDT mRNA CTD PMID:20493250 NCBI chr10:75,607,067...75,609,208
Ensembl chr10:75,607,064...75,609,248 		JBrowse link
G Dlst dihydrolipoamide S-succinyltransferase decreases expression EXP Warfarin results in decreased expression of DLST mRNA CTD PMID:20493250 NCBI chr12:85,157,597...85,180,865
Ensembl chr12:85,157,607...85,181,619 		JBrowse link
G Dock7 dedicator of cytokinesis 7 increases expression EXP Warfarin results in increased expression of DOCK7 mRNA CTD PMID:20493250 NCBI chr 4:98,824,669...99,019,190
Ensembl chr 4:98,824,908...99,009,152 		JBrowse link
G Dpysl2 dihydropyrimidinase-like 2 increases expression EXP Warfarin results in increased expression of DPYSL2 mRNA CTD PMID:20493250 NCBI chr14:67,040,313...67,148,490
Ensembl chr14:67,040,313...67,148,410 		JBrowse link
G Dstn destrin decreases expression EXP Warfarin results in decreased expression of DSTN mRNA CTD PMID:20493250 NCBI chr 2:143,757,251...143,785,244
Ensembl chr 2:143,757,240...143,785,244 		JBrowse link
G Eef2 eukaryotic translation elongation factor 2 decreases expression EXP Warfarin results in decreased expression of EEF2 mRNA CTD PMID:20493250 NCBI chr10:81,012,465...81,018,343
Ensembl chr10:81,012,465...81,018,332 		JBrowse link
G Eif3i eukaryotic translation initiation factor 3, subunit I decreases expression EXP Warfarin results in decreased expression of EIF3I mRNA CTD PMID:20493250 NCBI chr 4:129,485,767...129,494,441
Ensembl chr 4:129,485,753...129,494,441 		JBrowse link
G Emcn endomucin decreases expression ISO Warfarin results in decreased expression of EMCN protein CTD PMID:26206560 NCBI chr 3:137,046,824...137,136,830
Ensembl chr 3:137,046,828...137,137,946 		JBrowse link
G Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 increases expression ISO Warfarin results in increased expression of ENPP1 mRNA; Warfarin results in increased expression of ENPP1 protein CTD PMID:22659116 NCBI chr10:24,513,812...24,588,057
Ensembl chr10:24,513,812...24,588,057 		JBrowse link
G Epha7 Eph receptor A7 affects response to substance ISO EPHA7 promoter SNP affects the susceptibility to Warfarin CTD PMID:30357299 NCBI chr 4:28,811,840...28,969,391
Ensembl chr 4:28,813,131...28,967,499 		JBrowse link
G Ephx1 epoxide hydrolase 1, microsomal increases response to substance
affects response to substance		 ISO EPHX1 protein results in increased susceptibility to Warfarin
EPHX1 gene polymorphism affects the susceptibility to Warfarin; EPHX1 gene SNP affects the susceptibility to Warfarin; EPHX1 intron SNP affects the susceptibility to Warfarin; EPHX1 polymorphism affects the susceptibility to Warfarin; EPHX1 SNP affects the susceptibility to Warfarin		 CTD PMID:15900282 PMID:17496169 PMID:20842355 PMID:21192345 PMID:24092646 More... NCBI chr 1:180,817,121...180,845,134
Ensembl chr 1:180,803,775...180,848,469 		JBrowse link
G Erp29 endoplasmic reticulum protein 29 decreases expression EXP Warfarin results in decreased expression of ERP29 mRNA CTD PMID:20493250 NCBI chr 5:121,582,816...121,590,537
Ensembl chr 5:121,566,653...121,590,569 		JBrowse link
G F10 coagulation factor X decreases activity ISO Warfarin results in decreased activity of F10 protein CTD PMID:3490277 PMID:20371969 NCBI chr 8:13,087,308...13,106,676
Ensembl chr 8:13,087,308...13,106,676 		JBrowse link
G F2 coagulation factor II multiple interactions
decreases activity
decreases expression
affects response to substance		 ISO Fenofibrate promotes the reaction [Warfarin results in decreased expression of F2 protein]
Warfarin results in decreased activity of F2 protein
F2 gene polymorphism affects the susceptibility to Warfarin		 CTD PMID:3490277 PMID:9681093 PMID:14656880 NCBI chr 2:91,442,742...91,466,799
Ensembl chr 2:91,455,665...91,466,759 		JBrowse link
G F5 coagulation factor V affects response to substance
decreases activity		 ISO F5 gene polymorphism affects the susceptibility to Warfarin; F5 protein affects the susceptibility to Warfarin
Warfarin results in decreased activity of F5 protein		 CTD PMID:3490277 PMID:19752777 NCBI chr 1:163,979,396...164,048,539
Ensembl chr 1:163,979,407...164,047,846 		JBrowse link
G F7 coagulation factor VII affects response to substance
decreases activity
multiple interactions
decreases expression		 ISO F7 gene mutant form affects the susceptibility to Warfarin; F7 gene polymorphism affects the susceptibility to Warfarin
Warfarin results in decreased activity of F7 protein
Fenofibrate promotes the reaction [Warfarin results in decreased expression of F7 protein]		 CTD PMID:3490277 PMID:9681093 PMID:14656880 PMID:20371969 PMID:20885134 NCBI chr 8:13,075,499...13,085,809
Ensembl chr 8:13,076,034...13,085,809 		JBrowse link
G F9 coagulation factor IX decreases activity
increases response to substance		 ISO Warfarin results in decreased activity of F9 protein
F9 gene alternative form results in increased susceptibility to Warfarin		 CTD PMID:3490277 PMID:29450643 NCBI chr  X:59,044,675...59,076,120
Ensembl chr  X:59,044,824...59,076,119 		JBrowse link
G Fabp1 fatty acid binding protein 1, liver multiple interactions ISO Warfarin inhibits the reaction [3-(p-azidobenzyl)-4-hydroxycoumarin binds to Fabp1 protein] RGD PMID:1939124 RGD:1626448 NCBI chr 6:71,176,863...71,182,018
Ensembl chr 6:71,176,811...71,182,007 		JBrowse link
G Fgf5 fibroblast growth factor 5 affects response to substance ISO FGF5 gene affects the susceptibility to Warfarin CTD PMID:28686080 NCBI chr 5:98,402,108...98,424,892
Ensembl chr 5:98,402,043...98,424,889 		JBrowse link
G Fpgs folylpolyglutamyl synthetase affects response to substance ISO FPGS gene polymorphism affects the susceptibility to Warfarin CTD PMID:25079360 NCBI chr 2:32,572,621...32,594,163
Ensembl chr 2:32,572,621...32,594,157 		JBrowse link
G Fscn1 fascin actin-bundling protein 1 decreases expression EXP Warfarin results in decreased expression of FSCN1 mRNA CTD PMID:20493250 NCBI chr 5:142,946,110...142,958,944
Ensembl chr 5:142,946,098...142,958,940 		JBrowse link
G G3bp1 G3BP stress granule assembly factor 1 increases expression EXP Warfarin results in increased expression of G3BP1 mRNA CTD PMID:20493250 NCBI chr11:55,360,521...55,391,722
Ensembl chr11:55,360,511...55,395,664 		JBrowse link
G Gal3st1 galactose-3-O-sulfotransferase 1 increases expression EXP Warfarin results in increased expression of GAL3ST1 mRNA CTD PMID:27397090 NCBI chr11:3,933,636...3,949,328
Ensembl chr11:3,933,636...3,949,326 		JBrowse link
G Gale galactose-4-epimerase, UDP decreases expression EXP Warfarin results in decreased expression of GALE mRNA CTD PMID:20493250 NCBI chr 4:135,690,550...135,695,489
Ensembl chr 4:135,691,038...135,695,489 		JBrowse link
G Gas6 growth arrest specific 6 decreases expression
decreases carboxylation
multiple interactions		 ISO Warfarin results in decreased expression of GAS6 protein
Warfarin results in decreased carboxylation of GAS6 protein
Warfarin inhibits the reaction [GAS6 protein results in increased activity of AXL protein]
[Warfarin co-treated with Vitamin K 1] results in decreased expression of GAS6 protein; Vitamin K 2 inhibits the reaction [[Warfarin co-treated with Vitamin K 1] results in decreased expression of GAS6 protein]; Warfarin results in decreased activity of and results in decreased carboxylation of GAS6 protein		 CTD PMID:9163328 PMID:19564549 PMID:26206560 PMID:27212383 NCBI chr 8:13,515,374...13,544,535
Ensembl chr 8:13,515,374...13,544,490 		JBrowse link
G Gata4 GATA binding protein 4 affects response to substance ISO GATA4 gene SNP affects the susceptibility to Warfarin CTD PMID:31190750 NCBI chr14:63,436,363...63,509,161
Ensembl chr14:63,436,371...63,509,141 		JBrowse link
G Gata6 GATA binding protein 6 affects response to substance ISO GATA6 gene SNP affects the susceptibility to Warfarin CTD PMID:31190750 NCBI chr18:11,052,510...11,085,636
Ensembl chr18:11,052,064...11,085,635 		JBrowse link
G Gdi2 GDP dissociation inhibitor 2 increases expression EXP Warfarin results in increased expression of GDI2 mRNA CTD PMID:20493250 NCBI chr13:3,588,075...3,616,261
Ensembl chr13:3,588,063...3,617,871 		JBrowse link
G Gfap glial fibrillary acidic protein increases expression EXP Warfarin results in increased expression of GFAP mRNA; Warfarin results in increased expression of GFAP protein CTD PMID:27397090 NCBI chr11:102,778,162...102,791,368
Ensembl chr11:102,778,162...102,791,738 		JBrowse link
G Ggcx gamma-glutamyl carboxylase affects response to substance
increases activity
increases response to substance
decreases response to substance		 ISO GGCX gene polymorphism affects the susceptibility to Warfarin; GGCX gene SNP affects the susceptibility to Warfarin; GGCX polymorphism affects the susceptibility to Warfarin
Warfarin results in increased activity of GGCX protein
GGCX protein results in increased susceptibility to Warfarin
GGCX gene polymorphism results in decreased susceptibility to Warfarin		 CTD PMID:3490277 PMID:16676068 PMID:17049586 PMID:17496169 PMID:17764537 More... NCBI chr 6:72,391,262...72,407,696
Ensembl chr 6:72,391,291...72,407,695 		JBrowse link
G Gmps guanine monophosphate synthetase increases expression EXP Warfarin results in increased expression of GMPS mRNA CTD PMID:20493250 NCBI chr 3:63,871,054...63,928,975
Ensembl chr 3:63,883,527...63,930,000 		JBrowse link
G Gprc6a G protein-coupled receptor, family C, group 6, member A multiple interactions ISO Warfarin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of GPRC6A mRNA] CTD PMID:27488359 NCBI chr10:51,490,919...51,507,554
Ensembl chr10:51,490,919...51,507,557 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO [Warfarin co-treated with Vitamin K] results in increased phosphorylation of GSK3B protein; Quercetin inhibits the reaction [[Warfarin co-treated with Vitamin K] results in increased phosphorylation of GSK3B protein] CTD PMID:23117658 NCBI chr16:37,909,363...38,066,446
Ensembl chr16:37,909,363...38,066,446 		JBrowse link
G Hdac1 histone deacetylase 1 increases expression EXP Warfarin results in increased expression of HDAC1 mRNA CTD PMID:20493250 NCBI chr 4:129,409,897...129,436,516
Ensembl chr 4:129,409,897...129,436,506 		JBrowse link
G Hif1a hypoxia inducible factor 1, alpha subunit multiple interactions ISO epigallocatechin gallate promotes the reaction [Warfarin inhibits the reaction [Hydrogen Peroxide results in increased expression of HIF1A protein]]; Warfarin inhibits the reaction [Hydrogen Peroxide results in increased expression of HIF1A protein] CTD PMID:36162953 NCBI chr12:73,948,186...73,994,304
Ensembl chr12:73,948,149...73,994,304 		JBrowse link
G Hint1 histidine triad nucleotide binding protein 1 increases expression EXP Warfarin results in increased expression of HINT1 mRNA CTD PMID:20493250 NCBI chr11:54,757,209...54,761,332
Ensembl chr11:54,757,209...54,761,327 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-Coenzyme A reductase multiple interactions ISO Warfarin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of HMGCR mRNA] CTD PMID:27488359 NCBI chr13:96,785,470...96,807,444
Ensembl chr13:96,785,475...96,807,444 		JBrowse link
G Hmox1 heme oxygenase 1 affects expression ISO Warfarin affects the expression of HMOX1 mRNA CTD PMID:22954530 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217 		JBrowse link
G Hnrnpab heterogeneous nuclear ribonucleoprotein A/B increases expression EXP Warfarin results in increased expression of HNRNPAB mRNA CTD PMID:20493250 NCBI chr11:51,490,927...51,497,708
Ensembl chr11:51,490,927...51,497,674 		JBrowse link
G Hnrnpdl heterogeneous nuclear ribonucleoprotein D-like decreases expression EXP Warfarin results in decreased expression of HNRNPDL mRNA CTD PMID:20493250 NCBI chr 5:100,181,436...100,187,769
Ensembl chr 5:100,181,436...100,187,523 		JBrowse link
G Hnrnpf heterogeneous nuclear ribonucleoprotein F increases expression EXP Warfarin results in increased expression of HNRNPF mRNA CTD PMID:20493250 NCBI chr 6:117,877,301...117,902,583
Ensembl chr 6:117,877,285...117,902,583 		JBrowse link
G Hnrnpk heterogeneous nuclear ribonucleoprotein K increases expression
decreases expression		 EXP Warfarin results in increased expression of HNRNPK mRNA
Warfarin results in decreased expression of HNRNPK mRNA		 CTD PMID:20493250 NCBI chr13:58,538,946...58,551,157
Ensembl chr13:58,538,956...58,551,157 		JBrowse link
G Hp haptoglobin increases expression ISO Warfarin results in increased expression of HP protein CTD PMID:22342526 NCBI chr 8:110,301,760...110,305,804
Ensembl chr 8:110,301,760...110,305,804 		JBrowse link
G Hsp90ab1 heat shock protein 90 alpha (cytosolic), class B member 1 decreases expression EXP Warfarin results in decreased expression of HSP90AB1 mRNA CTD PMID:20493250 NCBI chr17:45,878,704...45,884,187
Ensembl chr17:45,878,701...45,884,197 		JBrowse link
G Hspa8 heat shock protein 8 increases expression EXP Warfarin results in increased expression of HSPA8 mRNA CTD PMID:20493250 NCBI chr 9:40,712,572...40,716,498
Ensembl chr 9:40,712,280...40,721,383 		JBrowse link
G Hspd1 heat shock protein 1 (chaperonin) increases expression EXP Warfarin results in increased expression of HSPD1 mRNA CTD PMID:20493250 NCBI chr 1:55,116,992...55,127,402
Ensembl chr 1:55,116,994...55,127,402 		JBrowse link
G Il12a interleukin 12a increases expression ISO Warfarin results in increased expression of IL12A mRNA CTD PMID:22342526 NCBI chr 3:68,597,977...68,605,881
Ensembl chr 3:68,597,977...68,605,880 		JBrowse link
G Il12b interleukin 12b increases expression ISO Warfarin results in increased expression of IL12B mRNA CTD PMID:22342526 NCBI chr11:44,290,890...44,305,504
Ensembl chr11:44,290,890...44,304,860 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases expression		 ISO Warfarin inhibits the reaction [Vitamin K 2 results in decreased susceptibility to IL1B protein]
Warfarin results in decreased expression of IL1B mRNA
[Warfarin co-treated with Vitamin K] results in increased expression of IL1B mRNA		 CTD PMID:20460758 PMID:23117658 PMID:29594315 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il2 interleukin 2 multiple interactions ISO [Warfarin co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IL2 mRNA CTD PMID:29594315 NCBI chr 3:37,174,862...37,180,103
Ensembl chr 3:37,174,672...37,180,108 		JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions
decreases expression
decreases secretion		 ISO
EXP		 Warfarin results in increased expression of IL6 protein
[Warfarin co-treated with Vitamin K] results in increased expression of IL6 mRNA
Warfarin results in decreased expression of IL6 mRNA
Warfarin results in decreased secretion of IL6 protein
Warfarin results in decreased expression of IL6 protein		 CTD PMID:18772604 PMID:22342526 PMID:23117658 PMID:26742017 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Ins1 insulin I multiple interactions
increases secretion		 ISO Warfarin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased secretion of INS1 protein]
Warfarin results in increased secretion of INS1 protein		 CTD PMID:27488359 NCBI chr19:52,252,735...52,253,453
Ensembl chr19:52,252,735...52,253,914 		JBrowse link
G Ipo5 importin 5 decreases expression EXP Warfarin results in decreased expression of IPO5 mRNA CTD PMID:20493250 NCBI chr14:121,134,271...121,185,451
Ensembl chr14:121,148,636...121,185,411 		JBrowse link
G Isyna1 myo-inositol 1-phosphate synthase A1 increases expression EXP Warfarin results in increased expression of ISYNA1 mRNA CTD PMID:20493250 NCBI chr 8:71,047,131...71,049,940
Ensembl chr 8:71,047,023...71,049,940 		JBrowse link
G Krt18 keratin 18 decreases expression EXP Warfarin results in decreased expression of KRT18 mRNA CTD PMID:20493250 NCBI chr15:101,936,651...101,940,461
Ensembl chr15:101,936,615...101,940,462 		JBrowse link
G Lasp1 LIM and SH3 protein 1 decreases expression EXP Warfarin results in decreased expression of LASP1 mRNA CTD PMID:20493250 NCBI chr11:97,689,748...97,729,591
Ensembl chr11:97,689,826...97,729,590 		JBrowse link
G Lrp1 low density lipoprotein receptor-related protein 1 affects response to substance ISO LRP1 gene SNP affects the susceptibility to Warfarin CTD PMID:32282500 NCBI chr10:127,374,026...127,457,158
Ensembl chr10:127,374,030...127,457,017 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions ISO epigallocatechin gallate promotes the reaction [Warfarin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein]]; Warfarin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein] CTD PMID:36162953 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions ISO epigallocatechin gallate promotes the reaction [Warfarin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein]]; Warfarin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein] CTD PMID:36162953 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991 		JBrowse link
G Mgp matrix Gla protein multiple interactions
decreases carboxylation		 EXP
ISO		 [[Warfarin co-treated with Vitamin K 1] results in decreased carboxylation of MGP protein] which results in decreased activity of MGP protein; [Warfarin co-treated with Vitamin K 1] results in decreased activity of MGP protein; [Warfarin co-treated with Vitamin K 1] results in decreased carboxylation of MGP protein; [Warfarin co-treated with Vitamin K 1] results in decreased expression of MGP mRNA
Warfarin results in decreased carboxylation of MGP protein
[Quercetin co-treated with Warfarin] results in decreased carboxylation of MGP protein; [Vitamin K co-treated with Warfarin] results in increased carboxylation of MGP protein; Warfarin inhibits the reaction [Vitamin K 1 results in increased expression of and results in increased secretion of MGP protein modified form]; Warfarin results in decreased expression of and results in decreased secretion of MGP protein; Warfarin results in decreased expression of and results in decreased secretion of MGP protein modified form		 CTD PMID:21705322 PMID:23223575 PMID:23990204 NCBI chr 6:136,849,433...136,852,821
Ensembl chr 6:136,849,433...136,852,821 		JBrowse link
G Mir133a-2 microRNA 133a-2 affects response to substance ISO MIR133A2 gene SNP affects the susceptibility to Warfarin CTD PMID:26113018 NCBI chr 2:180,040,172...180,040,275
Ensembl chr 2:180,040,172...180,040,275 		JBrowse link
G Mpo myeloperoxidase increases activity ISO Warfarin results in increased activity of MPO protein CTD PMID:26742017 NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239 		JBrowse link
G Myh1 myosin, heavy polypeptide 1, skeletal muscle, adult multiple interactions ISO [Warfarin co-treated with Vitamin K co-treated with Quercetin] results in increased expression of MYH1 mRNA CTD PMID:23117658 NCBI chr11:67,090,922...67,115,401
Ensembl chr11:67,090,878...67,115,401 		JBrowse link
G Myh6 myosin, heavy polypeptide 6, cardiac muscle, alpha affects response to substance ISO MYH6 polymorphism affects the susceptibility to Warfarin CTD PMID:34515533 NCBI chr14:55,179,378...55,205,553
Ensembl chr14:55,179,378...55,204,384 		JBrowse link
G Nedd4 neural precursor cell expressed, developmentally down-regulated 4 affects response to substance ISO NEDD4 gene SNP affects the susceptibility to Warfarin CTD PMID:27488176 NCBI chr 9:72,569,613...72,657,133
Ensembl chr 9:72,569,628...72,657,134 		JBrowse link
G Nmral1 NmrA-like family domain containing 1 increases expression EXP Warfarin results in increased expression of NMRAL1 mRNA CTD PMID:20493250 NCBI chr16:4,529,181...4,537,220
Ensembl chr16:4,527,923...4,537,220 		JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 affects response to substance ISO NQO1 gene SNP affects the susceptibility to Warfarin; NQO1 polymorphism affects the susceptibility to Warfarin CTD PMID:23215885 PMID:26257249 PMID:27581200 NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
decreases expression		 ISO [Warfarin binds to and results in increased activity of NR1I2 protein] which results in increased expression of CYP2C9 mRNA; [Warfarin binds to and results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; Warfarin binds to and results in increased activity of NR1I2 protein
Warfarin results in decreased expression of NR1I2 mRNA		 CTD PMID:20735727 PMID:30963258 NCBI chr16:38,068,711...38,115,211
Ensembl chr16:38,068,685...38,115,186 		JBrowse link
G Nucb1 nucleobindin 1 increases expression EXP Warfarin results in increased expression of NUCB1 mRNA CTD PMID:20493250 NCBI chr 7:45,142,300...45,159,813
Ensembl chr 7:45,139,882...45,159,830 		JBrowse link
G Numb NUMB endocytic adaptor protein multiple interactions ISO [Warfarin co-treated with Vitamin K] results in increased expression of NUMB mRNA; Quercetin inhibits the reaction [[Warfarin co-treated with Vitamin K] results in increased expression of NUMB mRNA] CTD PMID:23117658 NCBI chr12:83,840,808...83,968,708
Ensembl chr12:83,840,808...83,968,708 		JBrowse link
G Oat ornithine aminotransferase decreases expression EXP Warfarin results in decreased expression of OAT mRNA CTD PMID:20493250 NCBI chr 7:132,159,204...132,178,127
Ensembl chr 7:132,159,207...132,178,127 		JBrowse link
G Orm1 orosomucoid 1 multiple interactions
affects binding
increases response to substance
affects response to substance		 ISO Chlorpromazine inhibits the reaction [Warfarin binds to ORM1 protein alternative form]; Dipyridamole inhibits the reaction [Warfarin binds to ORM1 protein alternative form]; Lidocaine inhibits the reaction [Warfarin binds to ORM1 protein alternative form]; Progesterone inhibits the reaction [Warfarin binds to ORM1 protein alternative form]
ORM1 protein results in increased susceptibility to Warfarin
ORM1 gene polymorphism affects the susceptibility to Warfarin; ORM1 polymorphism affects the susceptibility to Warfarin		 CTD PMID:8946472 PMID:17496169 PMID:23208322 PMID:26644206 NCBI chr 4:63,262,793...63,266,400
Ensembl chr 4:63,262,797...63,266,400 		JBrowse link
G Pa2g4 proliferation-associated 2G4 increases expression EXP Warfarin results in increased expression of PA2G4 mRNA CTD PMID:20493250 NCBI chr10:128,393,635...128,401,803
Ensembl chr10:128,393,635...128,401,856 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 increases expression ISO Warfarin results in increased expression of PARP1 protein modified form CTD PMID:26206560 NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819 		JBrowse link
G Pdgfb platelet derived growth factor, B polypeptide decreases expression ISO Warfarin results in decreased expression of PDGFB mRNA; Warfarin results in decreased expression of PDGFB protein CTD PMID:11290560 NCBI chr15:79,880,066...79,899,178
Ensembl chr15:79,880,075...79,899,178 		JBrowse link
G Pdia3 protein disulfide isomerase associated 3 increases expression
decreases expression		 EXP Warfarin results in increased expression of PDIA3 mRNA
Warfarin results in decreased expression of PDIA3 mRNA		 CTD PMID:20493250 NCBI chr 2:121,244,383...121,269,168
Ensembl chr 2:121,244,256...121,269,168 		JBrowse link
G Pdia4 protein disulfide isomerase associated 4 decreases expression EXP Warfarin results in decreased expression of PDIA4 mRNA CTD PMID:20493250 NCBI chr 6:47,773,075...47,790,446
Ensembl chr 6:47,773,075...47,790,364 		JBrowse link
G Pgam1 phosphoglycerate mutase 1 decreases expression
increases expression		 EXP Warfarin results in decreased expression of PGAM1 mRNA
Warfarin results in increased expression of PGAM1 mRNA		 CTD PMID:20493250 NCBI chr19:41,900,310...41,907,104
Ensembl chr19:41,900,362...41,907,099 		JBrowse link
G Pkm pyruvate kinase, muscle decreases expression EXP Warfarin results in decreased expression of PKM mRNA CTD PMID:20493250 NCBI chr 9:59,563,859...59,586,655
Ensembl chr 9:59,563,651...59,586,658 		JBrowse link
G Plp1 proteolipid protein (myelin) 1 increases expression EXP Warfarin results in increased expression of PLP1 mRNA CTD PMID:27397090 NCBI chr  X:135,720,897...135,739,331
Ensembl chr  X:135,723,420...135,740,482 		JBrowse link
G Por cytochrome p450 oxidoreductase affects response to substance ISO POR gene SNP affects the susceptibility to Warfarin CTD PMID:27488389 NCBI chr 5:135,698,894...135,764,180
Ensembl chr 5:135,698,887...135,764,180 		JBrowse link
G Ppp1ca protein phosphatase 1 catalytic subunit alpha decreases expression EXP Warfarin results in decreased expression of PPP1CA mRNA CTD PMID:20493250 NCBI chr19:4,242,173...4,245,418
Ensembl chr19:4,242,064...4,245,419 		JBrowse link
G Ppp2r1a protein phosphatase 2, regulatory subunit A, alpha increases expression EXP Warfarin results in increased expression of PPP2R1A mRNA CTD PMID:20493250 NCBI chr17:21,165,716...21,186,167
Ensembl chr17:21,165,573...21,186,178 		JBrowse link
G Proc protein C increases response to substance
affects response to substance		 ISO PROC protein results in increased susceptibility to Warfarin
PROC gene polymorphism affects the susceptibility to Warfarin		 CTD PMID:17048007 PMID:17496169 NCBI chr18:32,256,179...32,272,623
Ensembl chr18:32,256,179...32,272,623 		JBrowse link
G Pros1 protein S (alpha) affects response to substance ISO PROS1 gene polymorphism affects the susceptibility to Warfarin; PROS1 protein affects the susceptibility to Warfarin CTD PMID:19752777 NCBI chr16:62,674,670...62,749,709
Ensembl chr16:62,674,670...62,749,709 		JBrowse link
G Prss53 serine protease 53 affects response to substance ISO PRSS53 gene SNP affects the susceptibility to Warfarin CTD PMID:21590310 NCBI chr 7:127,484,616...127,490,594
Ensembl chr 7:127,485,013...127,490,142 		JBrowse link
G Psma3 proteasome subunit alpha 3 decreases expression EXP Warfarin results in decreased expression of PSMA3 mRNA CTD PMID:20493250 NCBI chr12:71,016,082...71,042,651
Ensembl chr12:71,021,395...71,043,121 		JBrowse link
G Psma6 proteasome subunit alpha 6 decreases expression EXP Warfarin results in decreased expression of PSMA6 mRNA CTD PMID:20493250 NCBI chr12:55,431,007...55,465,244
Ensembl chr12:55,431,007...55,465,239 		JBrowse link
G Psmc2 proteasome (prosome, macropain) 26S subunit, ATPase 2 decreases expression EXP Warfarin results in decreased expression of PSMC2 mRNA CTD PMID:20493250 NCBI chr 5:21,990,273...22,008,785
Ensembl chr 5:21,990,281...22,008,785 		JBrowse link
G Pth parathyroid hormone decreases activity EXP Warfarin results in decreased activity of PTH protein CTD PMID:11564701 NCBI chr 7:112,984,783...112,987,879
Ensembl chr 7:112,984,787...112,987,777 		JBrowse link
G Rab1a RAB1A, member RAS oncogene family decreases expression EXP Warfarin results in decreased expression of RAB1A mRNA CTD PMID:20493250 NCBI chr11:20,151,412...20,176,856
Ensembl chr11:20,151,432...20,176,856 		JBrowse link
G Rhoa ras homolog family member A decreases expression EXP Warfarin results in decreased expression of RHOA mRNA CTD PMID:20493250 NCBI chr 9:108,183,359...108,215,142
Ensembl chr 9:108,183,328...108,215,133 		JBrowse link
G Rpl27 ribosomal protein L27 increases expression EXP Warfarin results in increased expression of RPL27 mRNA CTD PMID:20493250 NCBI chr11:101,333,071...101,336,422
Ensembl chr11:101,333,124...101,336,355 		JBrowse link
G Rpl9 ribosomal protein L9 increases expression EXP Warfarin results in increased expression of RPL9 mRNA CTD PMID:20493250 NCBI chr 5:65,545,707...65,548,774
Ensembl chr 5:65,545,707...65,548,787 		JBrowse link
G Rplp0 ribosomal protein lateral stalk subunit P0 increases expression EXP Warfarin results in increased expression of RPLP0 mRNA CTD PMID:20493250 NCBI chr 5:115,697,526...115,701,788
Ensembl chr 5:115,697,526...115,701,786 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase, polypeptide 1 multiple interactions ISO epigallocatechin gallate promotes the reaction [Warfarin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of RPS6KB1 protein]]; Warfarin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of RPS6KB1 protein] CTD PMID:36162953 NCBI chr11:86,389,695...86,435,711
Ensembl chr11:86,389,697...86,435,631 		JBrowse link
G Rpsa ribosomal protein SA increases expression EXP Warfarin results in increased expression of RPSA mRNA CTD PMID:20493250 NCBI chr 9:119,956,832...119,961,435
Ensembl chr 9:119,956,755...119,961,435 		JBrowse link
G Runx1 runt related transcription factor 1 multiple interactions
increases expression		 ISO Quercetin inhibits the reaction [Warfarin results in increased expression of RUNX1 mRNA] CTD PMID:23223575 NCBI chr16:92,398,354...92,622,962
Ensembl chr16:92,398,354...92,623,037 		JBrowse link
G Runx2 runt related transcription factor 2 multiple interactions EXP
ISO		 Warfarin inhibits the reaction [BMP2 protein results in increased activity of RUNX2 protein]; Warfarin inhibits the reaction [RUNX2 protein results in increased expression of ALPL mRNA]; Warfarin inhibits the reaction [RUNX2 protein results in increased expression of BGLAP mRNA]
[Warfarin co-treated with Vitamin K 1] affects the expression of RUNX2 mRNA; [Warfarin co-treated with Vitamin K 1] affects the expression of RUNX2 protein; [Warfarin co-treated with Vitamin K] results in increased expression of RUNX2 mRNA; Losartan affects the reaction [[Warfarin co-treated with Vitamin K 1] affects the expression of RUNX2 mRNA]; Losartan affects the reaction [[Warfarin co-treated with Vitamin K 1] affects the expression of RUNX2 protein]; Quercetin inhibits the reaction [[Warfarin co-treated with Vitamin K] results in increased expression of RUNX2 mRNA]		 CTD PMID:21910061 PMID:23117658 PMID:27412937 NCBI chr17:44,806,873...45,125,518
Ensembl chr17:44,806,874...45,125,684 		JBrowse link
G Ruvbl2 RuvB-like AAA ATPase 2 decreases expression EXP Warfarin results in decreased expression of RUVBL2 mRNA CTD PMID:20493250 NCBI chr 7:45,071,320...45,084,817
Ensembl chr 7:45,071,184...45,087,520 		JBrowse link
G Sae1 SUMO1 activating enzyme subunit 1 decreases expression EXP Warfarin results in decreased expression of SAE1 mRNA CTD PMID:20493250 NCBI chr 7:16,054,161...16,121,821
Ensembl chr 7:16,054,159...16,121,731 		JBrowse link
G Sephs1 selenophosphate synthetase 1 increases expression EXP Warfarin results in increased expression of SEPHS1 mRNA CTD PMID:20493250 NCBI chr 2:4,886,375...4,915,368
Ensembl chr 2:4,886,375...4,915,368 		JBrowse link
G Serpinc1 serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1 increases expression ISO Warfarin results in increased expression of SERPINC1 protein CTD PMID:73932 NCBI chr 1:160,806,153...160,830,113
Ensembl chr 1:160,806,155...160,833,433 		JBrowse link
G Slc15a2 solute carrier family 15 (H+/peptide transporter), member 2 affects response to substance ISO SLC15A2 gene SNP affects the susceptibility to Warfarin CTD PMID:29234073 NCBI chr16:36,570,523...36,605,506
Ensembl chr16:36,570,539...36,605,324 		JBrowse link
G Slco1b2 solute carrier organic anion transporter family, member 1b2 affects response to substance ISO SLCO1B3 gene SNP affects the susceptibility to Warfarin CTD PMID:29234073 NCBI chr 6:141,575,178...141,632,372
Ensembl chr 6:141,575,244...141,632,372 		JBrowse link
G Sost sclerostin affects response to substance EXP SOST affects the susceptibility to Warfarin CTD PMID:35038187 NCBI chr11:101,853,284...101,857,841
Ensembl chr11:101,853,284...101,857,841 		JBrowse link
G Sox5 SRY (sex determining region Y)-box 5 affects localization
decreases expression		 EXP Warfarin affects the localization of SOX5 protein
Warfarin results in decreased expression of SOX5 mRNA; Warfarin results in decreased expression of SOX5 protein		 CTD PMID:34520801 NCBI chr 6:143,774,151...144,728,008
Ensembl chr 6:143,774,151...144,727,703 		JBrowse link
G Sox9 SRY (sex determining region Y)-box 9 affects localization
multiple interactions		 EXP Warfarin affects the localization of SOX9 protein
leptomycin B inhibits the reaction [Warfarin affects the localization of SOX9 protein]		 CTD PMID:34520801 NCBI chr11:112,673,036...112,678,583
Ensembl chr11:112,673,050...112,678,586 		JBrowse link
G Sp7 Sp7 transcription factor 7 multiple interactions EXP Warfarin inhibits the reaction [BMP2 protein results in increased expression of SP7 mRNA] CTD PMID:21910061 NCBI chr15:102,265,038...102,275,498
Ensembl chr15:102,265,041...102,275,617 		JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions EXP
ISO		 [Warfarin co-treated with Vitamin K 1] results in increased expression of SPP1 mRNA
[Quercetin co-treated with Warfarin] results in increased expression of SPP1 mRNA; [Warfarin co-treated with Vitamin K] results in increased expression of SPP1 mRNA		 CTD PMID:23117658 PMID:23223575 PMID:23990204 NCBI chr 5:104,582,977...104,588,919
Ensembl chr 5:104,582,984...104,588,916 		JBrowse link
G Stip1 stress-induced phosphoprotein 1 decreases expression EXP Warfarin results in decreased expression of STIP1 mRNA CTD PMID:20493250 NCBI chr19:6,998,064...7,017,394
Ensembl chr19:6,998,070...7,017,335 		JBrowse link
G Tagln transgelin multiple interactions EXP
ISO		 [Warfarin co-treated with Vitamin K 1] results in decreased expression of TAGLN mRNA
[Warfarin co-treated with Vitamin K co-treated with Quercetin] results in increased expression of TAGLN mRNA		 CTD PMID:23117658 PMID:23990204 NCBI chr 9:45,840,926...45,847,356
Ensembl chr 9:45,840,917...45,847,356 		JBrowse link
G Tcf4 transcription factor 4 multiple interactions
increases expression		 ISO [Warfarin co-treated with Vitamin K] results in increased expression of TCF4 mRNA; Quercetin inhibits the reaction [[Warfarin co-treated with Vitamin K] results in increased expression of TCF4 mRNA]; Quercetin inhibits the reaction [Warfarin results in increased expression of TCF4 mRNA] CTD PMID:23117658 NCBI chr18:69,476,500...69,821,038
Ensembl chr18:69,476,427...69,822,150 		JBrowse link
G Tcp1 t-complex protein 1 increases expression EXP Warfarin results in increased expression of TCP1 mRNA CTD PMID:20493250 NCBI chr17:13,135,216...13,143,954
Ensembl chr17:13,134,588...13,143,954 		JBrowse link
G Tgm2 transglutaminase 2, C polypeptide affects response to substance
increases response to substance
multiple interactions		 EXP
ISO		 [TGM2 protein affects the susceptibility to Warfarin] which affects the susceptibility to Quercetin; TGM2 protein affects the susceptibility to Warfarin
TGM2 protein results in increased susceptibility to Warfarin
[Warfarin co-treated with Vitamin K] results in increased expression of and results in increased activity of TGM2 protein; Quercetin inhibits the reaction [[Warfarin co-treated with Vitamin K] results in increased expression of and results in increased activity of TGM2 protein]; Quercetin inhibits the reaction [Warfarin results in increased activity of TGM2 protein]; Warfarin results in increased expression of and results in increased activity of TGM2 protein		 CTD PMID:23117658 NCBI chr 2:157,958,325...157,988,312
Ensembl chr 2:157,958,322...157,988,356 		JBrowse link
G Thop1 thimet oligopeptidase 1 increases expression EXP Warfarin results in increased expression of THOP1 mRNA CTD PMID:20493250 NCBI chr10:80,905,917...80,918,194
Ensembl chr10:80,905,869...80,918,393 		JBrowse link
G Tnf tumor necrosis factor decreases expression
increases expression
multiple interactions
decreases secretion		 ISO Warfarin results in decreased expression of TNF mRNA
Warfarin results in increased expression of TNF
[Warfarin co-treated with Vitamin K] results in increased expression of TNF mRNA
Warfarin results in decreased secretion of TNF protein		 CTD PMID:21565690 PMID:22342526 PMID:23117658 PMID:26742017 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Trp53 transformation related protein 53 increases degradation
increases expression		 ISO
EXP		 Warfarin results in increased degradation of TP53 protein
Warfarin results in increased expression of TRP53 mRNA; Warfarin results in increased expression of TRP53 protein		 CTD PMID:14634213 PMID:29358327 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699 		JBrowse link
G Tuba1a tubulin, alpha 1A increases expression EXP Warfarin results in increased expression of TUBA1A mRNA CTD PMID:20493250 NCBI chr15:98,847,728...98,851,382
Ensembl chr15:98,847,718...98,851,584 		JBrowse link
G Tuba1b tubulin, alpha 1B increases expression
decreases expression		 EXP Warfarin results in increased expression of TUBA1B mRNA
Warfarin results in decreased expression of TUBA1B mRNA		 CTD PMID:20493250 NCBI chr15:98,829,310...98,832,271
Ensembl chr15:98,829,306...98,832,446 		JBrowse link
G Tubb5 tubulin, beta 5 class I decreases expression EXP Warfarin results in decreased expression of TUBB5 mRNA CTD PMID:20493250 NCBI chr17:36,144,812...36,149,193
Ensembl chr17:36,144,813...36,149,198 		JBrowse link
G Tufm Tu translation elongation factor, mitochondrial decreases expression EXP Warfarin results in decreased expression of TUFM mRNA CTD PMID:20493250 NCBI chr 7:126,086,445...126,089,903
Ensembl chr 7:126,086,533...126,089,903 		JBrowse link
G Tyro3 TYRO3 protein tyrosine kinase 3 decreases expression EXP Warfarin results in decreased expression of TYRO3 mRNA CTD PMID:18772604 PMID:27397090 NCBI chr 2:119,628,123...119,648,585
Ensembl chr 2:119,628,214...119,648,585 		JBrowse link
G U2af2 U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 2 increases expression EXP Warfarin results in increased expression of U2AF2 mRNA CTD PMID:20493250 NCBI chr 7:5,063,884...5,082,937
Ensembl chr 7:5,065,142...5,082,937 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase 1 family, polypeptide A1 multiple interactions
affects response to substance
increases metabolic processing		 ISO [UGT1A1 protein results in increased metabolism of Warfarin] which results in increased chemical synthesis of Glucuronides; [Warfarin binds to and results in decreased activity of UGT1A1 protein] which results in decreased glucuronidation of Estradiol; Warfarin binds to and results in decreased activity of UGT1A1 protein; Warfarin inhibits the reaction [UGT1A1 protein results in increased glucuronidation of Estradiol]
UGT1A1 gene SNP affects the susceptibility to Warfarin; UGT1A1 polymorphism affects the susceptibility to Warfarin		 CTD PMID:19408964 PMID:25312789 PMID:25393417 PMID:26223945 NCBI chr 1:88,139,681...88,147,724
Ensembl chr 1:88,139,681...88,146,719 		JBrowse link
G Ugt1a10 UDP glycosyltransferase 1 family, polypeptide A10 multiple interactions
increases metabolic processing		 ISO [UGT1A10 protein results in increased metabolism of Warfarin] which results in increased chemical synthesis of Glucuronides CTD PMID:19408964 NCBI chr 1:87,983,133...88,147,724
Ensembl chr 1:87,983,110...88,146,726 		JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 multiple interactions ISO [Warfarin binds to and results in increased activity of UGT1A3 protein] which results in increased glucuronidation of Vorinostat; Warfarin binds to and results in increased activity of UGT1A3 protein; Warfarin promotes the reaction [UGT1A3 protein results in increased glucuronidation of Vorinostat] CTD PMID:25393417 NCBI chr 1:88,128,333...88,147,724
Ensembl chr 1:88,128,323...88,146,719 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase 1 family, polypeptide A9 multiple interactions ISO [Warfarin binds to and affects the activity of UGT1A9 protein] which affects the glucuronidation of Propofol; Warfarin affects the reaction [UGT1A9 protein results in increased glucuronidation of Propofol]; Warfarin binds to and affects the activity of UGT1A9 protein CTD PMID:25393417 NCBI chr 1:87,998,501...88,147,724
Ensembl chr 1:87,998,522...88,146,719 		JBrowse link
G Ugt2b1 UDP glucuronosyltransferase 2 family, polypeptide B1 multiple interactions ISO [Warfarin binds to and results in decreased activity of UGT2B17 protein] which results in decreased glucuronidation of vorinostat; Warfarin binds to and results in decreased activity of UGT2B17 protein; Warfarin inhibits the reaction [UGT2B17 protein results in increased glucuronidation of vorinostat] CTD PMID:25393417 NCBI chr 5:87,064,498...87,074,362
Ensembl chr 5:87,064,497...87,074,389 		JBrowse link
G Ugt2b34 UDP glucuronosyltransferase 2 family, polypeptide B34 multiple interactions ISO [Warfarin binds to and results in decreased activity of UGT2B7 protein] which results in decreased glucuronidation of Zidovudine; Warfarin binds to and results in decreased activity of UGT2B7 protein; Warfarin inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Zidovudine] CTD PMID:25393417 NCBI chr 5:87,037,613...87,054,805
Ensembl chr 5:87,037,626...87,054,796 		JBrowse link
G Usp5 ubiquitin specific peptidase 5 (isopeptidase T) decreases expression EXP Warfarin results in decreased expression of USP5 mRNA CTD PMID:20493250 NCBI chr 6:124,791,982...124,806,404
Ensembl chr 6:124,791,982...124,806,447 		JBrowse link
G Vcp valosin containing protein decreases expression
increases expression		 EXP Warfarin results in decreased expression of VCP mRNA
Warfarin results in increased expression of VCP mRNA		 CTD PMID:20493250 NCBI chr 4:42,979,964...43,000,507
Ensembl chr 4:42,979,963...43,000,507 		JBrowse link
G Vdr vitamin D (1,25-dihydroxyvitamin D3) receptor affects response to substance ISO VDR gene SNP affects the susceptibility to Warfarin CTD PMID:28262345 PMID:29298995 NCBI chr15:97,752,308...97,806,177
Ensembl chr15:97,752,306...97,808,511 		JBrowse link
G Vegfa vascular endothelial growth factor A affects response to substance
multiple interactions		 ISO VEGFA gene SNP affects the susceptibility to Warfarin
epigallocatechin gallate promotes the reaction [Warfarin inhibits the reaction [Hydrogen Peroxide results in increased expression of VEGFA mRNA]]; epigallocatechin gallate promotes the reaction [Warfarin inhibits the reaction [Hydrogen Peroxide results in increased expression of VEGFA protein]]; Warfarin inhibits the reaction [Hydrogen Peroxide results in increased expression of VEGFA mRNA]; Warfarin inhibits the reaction [Hydrogen Peroxide results in increased expression of VEGFA protein]		 CTD PMID:31068094 PMID:36162953 NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295 		JBrowse link
G Vim vimentin decreases expression ISO Warfarin results in decreased expression of VIM protein CTD PMID:26206560 NCBI chr 2:13,579,122...13,587,637
Ensembl chr 2:13,578,738...13,587,637 		JBrowse link
G Vkorc1 vitamin K epoxide reductase complex, subunit 1 multiple interactions
decreases activity
affects abundance
decreases response to substance
affects response to substance
affects metabolic processing
increases response to substance
decreases metabolic processing		 ISO
EXP		 [CYP4F2 gene polymorphism co-treated with VKORC1 gene mutant form] affects the susceptibility to Warfarin; Warfarin binds to and results in decreased activity of VKORC1 protein; Warfarin inhibits the reaction [VKORC1 protein results in increased reduction of Vitamin K 1]; Warfarin inhibits the reaction [VKORC1 protein results in increased reduction of vitamin K1 oxide]
Warfarin results in decreased activity of VKORC1 protein
VKORC1 gene polymorphism affects the abundance of Warfarin
VKORC1 3' UTR results in decreased susceptibility to Warfarin; VKORC1 gene mutant form results in decreased susceptibility to Warfarin; VKORC1 gene polymorphism results in decreased susceptibility to Warfarin
VKORC1 3' UTR SNP affects the susceptibility to Warfarin; VKORC1 affects the susceptibility to Warfarin; VKORC1 alternative form affects the susceptibility to Warfarin; VKORC1 gene affects the susceptibility to Warfarin; VKORC1 gene mutant form affects the susceptibility to Warfarin; VKORC1 gene polymorphism affects the susceptibility to Warfarin; VKORC1 gene SNP affects the susceptibility to Warfarin; VKORC1 intron polymorphism affects the susceptibility to Warfarin; VKORC1 intron SNP affects the susceptibility to Warfarin; VKORC1 polymorphism affects the susceptibility to Warfarin; VKORC1 promoter polymorphism affects the susceptibility to Warfarin; VKORC1 promoter SNP affects the susceptibility to Warfarin; VKORC1 protein affects the susceptibility to Warfarin; VKORC1 protein polymorphism affects the susceptibility to Warfarin; VKORC1 protein SNP affects the susceptibility to Warfarin; VKORC1 SNP affects the susceptibility to Warfarin
Warfarin inhibits the reaction [VKORC1 protein affects the reduction of vitamin K1 oxide]
VKORC1 gene mutant form results in decreased susceptibility to Warfarin; VKORC1 protein polymorphism results in decreased susceptibility to Warfarin
VKORC1 protein mutant form affects the susceptibility to Warfarin
VKORC1 protein affects the metabolism of Warfarin
VKORC1 intron polymorphism results in increased susceptibility to Warfarin; VKORC1 protein results in increased susceptibility to Warfarin; VKORC1 results in increased susceptibility to Warfarin
VKORC1 gene polymorphism results in decreased metabolism of Warfarin		 CTD PMID:14765194 PMID:14765195 PMID:15358623 PMID:15578879 PMID:15630486 More... NCBI chr 7:127,492,235...127,494,833
Ensembl chr 7:127,485,399...127,494,626
Ensembl chr 7:127,485,399...127,494,626 		JBrowse link
G Vkorc1l1 vitamin K epoxide reductase complex, subunit 1-like 1 multiple interactions ISO Warfarin affects the reaction [VKORC1L1 protein results in increased reduction of vitamin K1 oxide]; Warfarin binds to and results in decreased activity of VKORC1L1 protein; Warfarin inhibits the reaction [VKORC1L1 protein results in increased metabolism of vitamin K1 oxide]; Warfarin inhibits the reaction [VKORC1L1 protein results in increased reduction of Vitamin K 1]; Warfarin inhibits the reaction [VKORC1L1 protein results in increased reduction of vitamin K1 oxide] CTD PMID:23710884 PMID:23928358 PMID:29581108 NCBI chr 5:129,970,950...130,015,533
Ensembl chr 5:129,970,811...130,015,533 		JBrowse link
G Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide increases expression EXP Warfarin results in increased expression of YWHAE mRNA CTD PMID:20493250 NCBI chr11:75,620,121...75,656,667
Ensembl chr11:75,623,695...75,656,671 		JBrowse link
G Zeb1 zinc finger E-box binding homeobox 1 decreases expression ISO Warfarin results in decreased expression of ZEB1 protein CTD PMID:26206560 NCBI chr18:5,591,330...5,775,468
Ensembl chr18:5,591,860...5,775,467 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22221
    chemical entity 22220
      molecular entity 22212
        polyatomic entity 22115
          molecule 21709
            cyclic compound 21289
              aromatic compound 20773
                organic aromatic compound 20773
                  phenylpropanoid 11533
                    coumarins 4149
                      hydroxycoumarin 356
                        (S)-Neomammein 0
                        11-Methylgerberinol 0
                        2-(5,7-dihydroxy-4-methyl-2-oxo-1-benzopyran-3-yl)acetic acid ethyl ester 0
                        2-hydroxy-Alternariol 0
                        3,4,7-trihydroxy-6-methylcoumarin 0
                        3,7-dihydroxy-2H-chromen-2-one 0
                        3,8-dibromo-7-hydroxy-4-methyl-1-benzopyran-2-one 0
                        3-(1,1-Dimethylallyl)-8-hydroxy-7-methoxycoumarin 0
                        3-(1,1-Dimethylallyl)scopoletin 0
                        3-(4-azidobenzyl)-4-hydroxycoumarin 0
                        3-(dimethylamino)benzoic acid (7-hydroxy-2-oxo-1-benzopyran-4-yl)methyl ester 0
                        3-Amino-4,7-dihydroxy-8-chlorocoumarin 0
                        3-Hydroxyalternariol 5-O-methyl ether 0
                        3-O-demethylaltenuisol 0
                        3-[3-[(2,4-dinitrophenyl)hydrazinylidene]-1-phenylbutyl]-4-hydroxy-1-benzopyran-2-one 0
                        3-amino-4,7-dihydroxy-8-methylcoumarin 0
                        3-amino-4,7-dihydroxycoumarin + 0
                        3-bromo-7-hydroxy-4,8-dimethyl-1-benzopyran-2-one 0
                        3-hydroxy-1-benzopyran-2-one 0
                        3-hydroxy-2-oxo-2H-chromene-4,6-dicarboxylic acid 0
                        3-hydroxy-6-[(E)-2-methoxyethenyl]-7-methyl-2H-chromen-2-one 0
                        3-hydroxy-6-methyl-2H-chromen-2-one 0
                        4'-Hydroxy-R-phenprocoumon 0
                        4,6,7-trihydroxy-2H-chromen-2-one 0
                        4,6-dihydroxy-3,7-dimethylcoumarin 0
                        4,6-dihydroxy-7-formyl-3-methylcoumarin 0
                        4,6-dihydroxy-7-hydroxymethyl-3-methoxymethylcoumarin 0
                        4,6-dihydroxy-7-hydroxymethyl-3-methylcoumarin 0
                        4,7-Dihydroxy-2H-1-benzopyran-2-one 0
                        4,7-dihydroxy-5-methylcoumarin + 0
                        4-Hydroxyalternariol 0
                        4-ethyl-7-hydroxy-3-(p-methoxyphenyl)coumarin 0
                        4-hydroxy-3-(1-piperidinylmethyl)-1-benzopyran-2-one 0
                        4-hydroxy-3-(2-hydroxy-3-oxo-1-phenylbutyl)-2H-chromen-2-one 3
                        4-hydroxy-3-(3-hydroxy-1-phenylbutyl)-2H-chromen-2-one 0
                        4-hydroxy-3-(3-oxo-1-phenylbutyl)-1-benzopyran-2-one + 195
                        4-hydroxy-3-[1-(2-hydroxyphenyl)-3-oxobutyl]-2H-chromen-2-one 0
                        4-hydroxy-3-[1-(4-hydroxyphenyl)-3-oxobutyl]-2H-chromen-2-one 3
                        4-hydroxycoumarin 8
                        4-methylumbelliferone + 30
                        5,7-Dihydroxy-4-methylcoumarin 0
                        5,7-dihydroxy-4-methyl-3-(phenylmethyl)-1-benzopyran-2-one 0
                        5,7-dihydroxy-6-(3-methylbut-2-enyl)-8-(3-methylbutanoyl)-4-pentyl-2H-chromen-2-one 0
                        5,7-dihydroxy-8-(3-methylbut-2-enyl)-6-(3-methylbutanoyl)-4-propyl-2H-chromen-2-one 0
                        5-De-O-methyltoddanol 0
                        5-[[(4,7-Dihydroxy-2-oxo-2H-1-benzopyran-3-yl)amino]carbonyl]-4-methyl-1H-pyrrole-3-carboxylate 0
                        5-hydroxy-2H-chromen-2-one 0
                        6,7-dihydroxy-4-methylcoumarin 0
                        6,8-difluoro-7-hydroxy-4-methylcoumarin + 0
                        6-Formylumbelliferone 0
                        6-Hydroxy-7-methylesculetin 0
                        6-Hydroxy-R-acenocoumarol 0
                        6-Hydroxy-R-phenprocoumon 0
                        6-chloro-3-[2-[4-[2,3-dihydro-1,4-benzodioxin-3-yl(oxo)methyl]-1-piperazinyl]-2-oxoethyl]-7-hydroxy-4-methyl-1-benzopyran-2-one 0
                        6-chloro-4-[[(2-fluorophenyl)methyl-methylamino]methyl]-7-hydroxy-1-benzopyran-2-one 0
                        6-chloro-4-hydroxycoumarin 0
                        6-chloro-7-hydroxy-4-(4-morpholinylmethyl)-1-benzopyran-2-one 0
                        6-ethyl-7-hydroxy-4-[[4-(2-hydroxyethyl)-1-piperazinyl]methyl]-1-benzopyran-2-one 0
                        6-hydroxy-4-methyl-2-oxo-2H-chromen-7-yl acetate 0
                        7,7'-Dihydroxy-6,8'-bicoumarin 0
                        7,8-dihydroxy-4-methyl-1-benzopyran-2-one + 17
                        7,8-dihydroxycoumarin + 24
                        7-(diethylamino)-4-hydroxy-1-benzopyran-2-one 0
                        7-(gamma,gamma-dimethylallyloxy)-6-hydroxy-4-methylcoumarin 0
                        7-Hydroxy-4-(methoxymethyl)coumarin 0
                        7-Hydroxy-6-methyl-2H-1-benzopyran-2-one 0
                        7-Hydroxy-R-acenocoumarol 0
                        7-Hydroxy-R-phenprocoumon 0
                        7-Hydroxywarfarin 3
                        7-demethylsiderin 0
                        7-demethylsuberosin + 0
                        7-hydroxy-3-(2-methylbut-3-en-2-yl)-2H-chromen-2-one 0
                        7-hydroxy-3-(4-methoxyphenyl)-4-methylcoumarin 0
                        7-hydroxy-3-(4-methoxyphenyl)-4-propyl-2H-1-benzopyran-2-one 0
                        7-hydroxy-3-methoxy-2-oxo-2h-chromene-6-carboxylic acid 0
                        7-hydroxy-6-(3-oxobutyl)-2H-chromen-2-one 0
                        7-hydroxy-6-(hydroxymethyl)-2H-chromen-2-one 0
                        7-hydroxy-8-[[4-(2-hydroxyethyl)-1-piperazinyl]methyl]-4-methyl-1-benzopyran-2-one 0
                        7-hydroxy-8-methoxycoumarin 0
                        7-hydroxy-8-methyl-4-[[methyl-(phenylmethyl)amino]methyl]-1-benzopyran-2-one 0
                        8-Hydroxy-7-methoxy-2H-1-benzopyran-2-one 0
                        8-Hydroxy-R-acenocoumarol 0
                        8-Hydroxy-R-phenprocoumon 0
                        8-Methoxygravelliferone 0
                        8-[(3,3-dimethyloxiran-2-yl)methyl]-6-hydroxy-7-methoxy-2H-chromen-2-one 0
                        8-[(3,3-dimethyloxiran-2-yl)methyl]-7-hydroxy-2H-chromen-2-one 0
                        8-desmethylnovobiocic acid 0
                        8-geranylesculetin 0
                        8-geranylumbelliferone 0
                        Altertenuol 0
                        Apigravin 0
                        Aspyranochromenone A 0
                        Aspyranochromenone B 0
                        Bicoumanigrin 0
                        Celerin 0
                        Chlorobiocic acid 0
                        Coumabiocin F 0
                        Coumachlor 2
                        Coumafuryl 0
                        Coumaphos anti-dimer 0
                        Coumaphos syn-dimer 0
                        Coumatetralyl 2
                        Coumermic acid 0
                        Coumeroic acid 0
                        Cralactone A 0
                        Cralactone B 0
                        Cristaldehyde A 0
                        Dehydrowarfarin 0
                        Epicoccalone 0
                        Fraxidin 0
                        Fraxinol 0
                        Gerberinol 0
                        Gravelliferone 0
                        Hypoxyloamide 0
                        Isofraxidin 0
                        Isokotanin B 0
                        Isokotanin C 0
                        Leptodactylone 0
                        Liqcoumarin 0
                        Mammea B/AB 0
                        Mammea B/AB, (-)- 0
                        Mammea B/AC 0
                        Mammea B/BA 0
                        Mammea B/BB, (-)- 0
                        Mammea B/BD 0
                        Mammea C/AA 0
                        Mammea C/AB, (-)- 0
                        Mammea C/BB, (-)- 0
                        Mammea E/BA 0
                        Mammea E/BB 0
                        Mammea F/BA, (-)- 0
                        Mammea F/BB, (-)- 0
                        Monankarin C 0
                        Monankarin E 0
                        Monankarin F 0
                        Normammein 0
                        Pestalasin D 0
                        Pestalasin E 0
                        Peucedanol 0
                        Peucedanone 0
                        Pheofungin B 0
                        Protorubradirin 0
                        Quadriseptin A 0
                        R-10-Hydroxywarfarin 0
                        R-4'-Hydroxywarfarin 0
                        R-6-Hydroxywarfarin 0
                        R-7-Hydroxywarfarin 0
                        R-8-Hydroxywarfarin 0
                        Rubradirin B 0
                        S-4'-Hydroxywarfarin 0
                        S-6-Hydroxywarfarin 0
                        SCHEMBL2830381 0
                        Safficinolide 0
                        Sagecoumarin 0
                        Simocyclinone D4 0
                        Simocyclinone D8 0
                        Talacoumarin A 0
                        Talacoumarin B 0
                        Urolithin D 0
                        \{[1-(7-hydroxy-2-oxo-2H-chromen-8-yl)-3-methylbut-3-en-2-yl]oxy\}sulfonic acid 0
                        acenocoumarol + 15
                        asphodelin A + 0
                        asphodelin A-4'-O-beta-glucoside 0
                        cacibiocin A + 0
                        coumetarol 0
                        daphnoretin 0
                        descarbamoylnovobiocin 0
                        desmethyldescarbamoylnovobiocin 0
                        dicoumarol 40
                        esculetin + 75
                        esculin + 0
                        ethyl biscoumacetate 1
                        folescutol 0
                        fraxetin + 19
                        fraxin 0
                        fukanemarin A 0
                        fukanemarin B 0
                        isoscopoletin 0
                        lonchocarpenin 0
                        metesculetol 0
                        novclobiocin 109 0
                        novobiocic acid 0
                        novobiocin 5
                        osthenol 0
                        pacific blue + 0
                        pacific blue succinimidyl ester 0
                        paerucumarin 0
                        phenprocoumon 10
                        scopoletin + 39
                        sideretin (reduced form) + 0
                        tioclomarol 0
                        umbelliferone + 110
Path 2
Term Annotations click to browse term
  CHEBI ontology 22221
    subatomic particle 22213
      composite particle 22213
        hadron 22213
          baryon 22213
            nucleon 22213
              atomic nucleus 22213
                atom 22213
                  main group element atom 22147
                    p-block element atom 22147
                      carbon group element atom 21943
                        carbon atom 21868
                          organic molecular entity 21868
                            organic molecule 21685
                              organic cyclic compound 21288
                                organic heterocyclic compound 20356
                                  oxacycle 18880
                                    benzopyran 12209
                                      1-benzopyran 11968
                                        chromenes 4434
                                          chromenone 4377
                                            coumarins 4149
                                              hydroxycoumarin 356
                                                (S)-Neomammein 0
                                                11-Methylgerberinol 0
                                                2-(5,7-dihydroxy-4-methyl-2-oxo-1-benzopyran-3-yl)acetic acid ethyl ester 0
                                                2-hydroxy-Alternariol 0
                                                3,4,7-trihydroxy-6-methylcoumarin 0
                                                3,7-dihydroxy-2H-chromen-2-one 0
                                                3,8-dibromo-7-hydroxy-4-methyl-1-benzopyran-2-one 0
                                                3-(1,1-Dimethylallyl)-8-hydroxy-7-methoxycoumarin 0
                                                3-(1,1-Dimethylallyl)scopoletin 0
                                                3-(4-azidobenzyl)-4-hydroxycoumarin 0
                                                3-(dimethylamino)benzoic acid (7-hydroxy-2-oxo-1-benzopyran-4-yl)methyl ester 0
                                                3-Amino-4,7-dihydroxy-8-chlorocoumarin 0
                                                3-Hydroxyalternariol 5-O-methyl ether 0
                                                3-O-demethylaltenuisol 0
                                                3-[3-[(2,4-dinitrophenyl)hydrazinylidene]-1-phenylbutyl]-4-hydroxy-1-benzopyran-2-one 0
                                                3-amino-4,7-dihydroxy-8-methylcoumarin 0
                                                3-amino-4,7-dihydroxycoumarin + 0
                                                3-bromo-7-hydroxy-4,8-dimethyl-1-benzopyran-2-one 0
                                                3-hydroxy-1-benzopyran-2-one 0
                                                3-hydroxy-2-oxo-2H-chromene-4,6-dicarboxylic acid 0
                                                3-hydroxy-6-[(E)-2-methoxyethenyl]-7-methyl-2H-chromen-2-one 0
                                                3-hydroxy-6-methyl-2H-chromen-2-one 0
                                                4'-Hydroxy-R-phenprocoumon 0
                                                4,6,7-trihydroxy-2H-chromen-2-one 0
                                                4,6-dihydroxy-3,7-dimethylcoumarin 0
                                                4,6-dihydroxy-7-formyl-3-methylcoumarin 0
                                                4,6-dihydroxy-7-hydroxymethyl-3-methoxymethylcoumarin 0
                                                4,6-dihydroxy-7-hydroxymethyl-3-methylcoumarin 0
                                                4,7-Dihydroxy-2H-1-benzopyran-2-one 0
                                                4,7-dihydroxy-5-methylcoumarin + 0
                                                4-Hydroxyalternariol 0
                                                4-ethyl-7-hydroxy-3-(p-methoxyphenyl)coumarin 0
                                                4-hydroxy-3-(1-piperidinylmethyl)-1-benzopyran-2-one 0
                                                4-hydroxy-3-(2-hydroxy-3-oxo-1-phenylbutyl)-2H-chromen-2-one 3
                                                4-hydroxy-3-(3-hydroxy-1-phenylbutyl)-2H-chromen-2-one 0
                                                4-hydroxy-3-(3-oxo-1-phenylbutyl)-1-benzopyran-2-one + 195
                                                4-hydroxy-3-[1-(2-hydroxyphenyl)-3-oxobutyl]-2H-chromen-2-one 0
                                                4-hydroxy-3-[1-(4-hydroxyphenyl)-3-oxobutyl]-2H-chromen-2-one 3
                                                4-hydroxycoumarin 8
                                                4-methylumbelliferone + 30
                                                5,7-Dihydroxy-4-methylcoumarin 0
                                                5,7-dihydroxy-4-methyl-3-(phenylmethyl)-1-benzopyran-2-one 0
                                                5,7-dihydroxy-6-(3-methylbut-2-enyl)-8-(3-methylbutanoyl)-4-pentyl-2H-chromen-2-one 0
                                                5,7-dihydroxy-8-(3-methylbut-2-enyl)-6-(3-methylbutanoyl)-4-propyl-2H-chromen-2-one 0
                                                5-De-O-methyltoddanol 0
                                                5-[[(4,7-Dihydroxy-2-oxo-2H-1-benzopyran-3-yl)amino]carbonyl]-4-methyl-1H-pyrrole-3-carboxylate 0
                                                5-hydroxy-2H-chromen-2-one 0
                                                6,7-dihydroxy-4-methylcoumarin 0
                                                6,8-difluoro-7-hydroxy-4-methylcoumarin + 0
                                                6-Formylumbelliferone 0
                                                6-Hydroxy-7-methylesculetin 0
                                                6-Hydroxy-R-acenocoumarol 0
                                                6-Hydroxy-R-phenprocoumon 0
                                                6-chloro-3-[2-[4-[2,3-dihydro-1,4-benzodioxin-3-yl(oxo)methyl]-1-piperazinyl]-2-oxoethyl]-7-hydroxy-4-methyl-1-benzopyran-2-one 0
                                                6-chloro-4-[[(2-fluorophenyl)methyl-methylamino]methyl]-7-hydroxy-1-benzopyran-2-one 0
                                                6-chloro-4-hydroxycoumarin 0
                                                6-chloro-7-hydroxy-4-(4-morpholinylmethyl)-1-benzopyran-2-one 0
                                                6-ethyl-7-hydroxy-4-[[4-(2-hydroxyethyl)-1-piperazinyl]methyl]-1-benzopyran-2-one 0
                                                6-hydroxy-4-methyl-2-oxo-2H-chromen-7-yl acetate 0
                                                7,7'-Dihydroxy-6,8'-bicoumarin 0
                                                7,8-dihydroxy-4-methyl-1-benzopyran-2-one + 17
                                                7,8-dihydroxycoumarin + 24
                                                7-(diethylamino)-4-hydroxy-1-benzopyran-2-one 0
                                                7-(gamma,gamma-dimethylallyloxy)-6-hydroxy-4-methylcoumarin 0
                                                7-Hydroxy-4-(methoxymethyl)coumarin 0
                                                7-Hydroxy-6-methyl-2H-1-benzopyran-2-one 0
                                                7-Hydroxy-R-acenocoumarol 0
                                                7-Hydroxy-R-phenprocoumon 0
                                                7-Hydroxywarfarin 3
                                                7-demethylsiderin 0
                                                7-demethylsuberosin + 0
                                                7-hydroxy-3-(2-methylbut-3-en-2-yl)-2H-chromen-2-one 0
                                                7-hydroxy-3-(4-methoxyphenyl)-4-methylcoumarin 0
                                                7-hydroxy-3-(4-methoxyphenyl)-4-propyl-2H-1-benzopyran-2-one 0
                                                7-hydroxy-3-methoxy-2-oxo-2h-chromene-6-carboxylic acid 0
                                                7-hydroxy-6-(3-oxobutyl)-2H-chromen-2-one 0
                                                7-hydroxy-6-(hydroxymethyl)-2H-chromen-2-one 0
                                                7-hydroxy-8-[[4-(2-hydroxyethyl)-1-piperazinyl]methyl]-4-methyl-1-benzopyran-2-one 0
                                                7-hydroxy-8-methoxycoumarin 0
                                                7-hydroxy-8-methyl-4-[[methyl-(phenylmethyl)amino]methyl]-1-benzopyran-2-one 0
                                                8-Hydroxy-7-methoxy-2H-1-benzopyran-2-one 0
                                                8-Hydroxy-R-acenocoumarol 0
                                                8-Hydroxy-R-phenprocoumon 0
                                                8-Methoxygravelliferone 0
                                                8-[(3,3-dimethyloxiran-2-yl)methyl]-6-hydroxy-7-methoxy-2H-chromen-2-one 0
                                                8-[(3,3-dimethyloxiran-2-yl)methyl]-7-hydroxy-2H-chromen-2-one 0
                                                8-desmethylnovobiocic acid 0
                                                8-geranylesculetin 0
                                                8-geranylumbelliferone 0
                                                Altertenuol 0
                                                Apigravin 0
                                                Aspyranochromenone A 0
                                                Aspyranochromenone B 0
                                                Bicoumanigrin 0
                                                Celerin 0
                                                Chlorobiocic acid 0
                                                Coumabiocin F 0
                                                Coumachlor 2
                                                Coumafuryl 0
                                                Coumaphos anti-dimer 0
                                                Coumaphos syn-dimer 0
                                                Coumatetralyl 2
                                                Coumermic acid 0
                                                Coumeroic acid 0
                                                Cralactone A 0
                                                Cralactone B 0
                                                Cristaldehyde A 0
                                                Dehydrowarfarin 0
                                                Epicoccalone 0
                                                Fraxidin 0
                                                Fraxinol 0
                                                Gerberinol 0
                                                Gravelliferone 0
                                                Hypoxyloamide 0
                                                Isofraxidin 0
                                                Isokotanin B 0
                                                Isokotanin C 0
                                                Leptodactylone 0
                                                Liqcoumarin 0
                                                Mammea B/AB 0
                                                Mammea B/AB, (-)- 0
                                                Mammea B/AC 0
                                                Mammea B/BA 0
                                                Mammea B/BB, (-)- 0
                                                Mammea B/BD 0
                                                Mammea C/AA 0
                                                Mammea C/AB, (-)- 0
                                                Mammea C/BB, (-)- 0
                                                Mammea E/BA 0
                                                Mammea E/BB 0
                                                Mammea F/BA, (-)- 0
                                                Mammea F/BB, (-)- 0
                                                Monankarin C 0
                                                Monankarin E 0
                                                Monankarin F 0
                                                Normammein 0
                                                Pestalasin D 0
                                                Pestalasin E 0
                                                Peucedanol 0
                                                Peucedanone 0
                                                Pheofungin B 0
                                                Protorubradirin 0
                                                Quadriseptin A 0
                                                R-10-Hydroxywarfarin 0
                                                R-4'-Hydroxywarfarin 0
                                                R-6-Hydroxywarfarin 0
                                                R-7-Hydroxywarfarin 0
                                                R-8-Hydroxywarfarin 0
                                                Rubradirin B 0
                                                S-4'-Hydroxywarfarin 0
                                                S-6-Hydroxywarfarin 0
                                                SCHEMBL2830381 0
                                                Safficinolide 0
                                                Sagecoumarin 0
                                                Simocyclinone D4 0
                                                Simocyclinone D8 0
                                                Talacoumarin A 0
                                                Talacoumarin B 0
                                                Urolithin D 0
                                                \{[1-(7-hydroxy-2-oxo-2H-chromen-8-yl)-3-methylbut-3-en-2-yl]oxy\}sulfonic acid 0
                                                acenocoumarol + 15
                                                asphodelin A + 0
                                                asphodelin A-4'-O-beta-glucoside 0
                                                cacibiocin A + 0
                                                coumetarol 0
                                                daphnoretin 0
                                                descarbamoylnovobiocin 0
                                                desmethyldescarbamoylnovobiocin 0
                                                dicoumarol 40
                                                esculetin + 75
                                                esculin + 0
                                                ethyl biscoumacetate 1
                                                folescutol 0
                                                fraxetin + 19
                                                fraxin 0
                                                fukanemarin A 0
                                                fukanemarin B 0
                                                isoscopoletin 0
                                                lonchocarpenin 0
                                                metesculetol 0
                                                novclobiocin 109 0
                                                novobiocic acid 0
                                                novobiocin 5
                                                osthenol 0
                                                pacific blue + 0
                                                pacific blue succinimidyl ester 0
                                                paerucumarin 0
                                                phenprocoumon 10
                                                scopoletin + 39
                                                sideretin (reduced form) + 0
                                                tioclomarol 0
                                                umbelliferone + 110
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