Acaa1a (acetyl-Coenzyme A acyltransferase 1A) - Rat Genome Database
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Gene: Acaa1a (acetyl-Coenzyme A acyltransferase 1A) Mus musculus
Analyze
Symbol: Acaa1a
Name: acetyl-Coenzyme A acyltransferase 1A
RGD ID: 735985
MGI Page MGI
Description: Predicted to have C-acyltransferase activity; acetate CoA-transferase activity; and palmitoyl-CoA oxidase activity. Predicted to be involved in monocarboxylic acid metabolic process. Localizes to peroxisome. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human ACAA1 (acetyl-CoA acyltransferase 1); PARTICIPATES IN valine, leucine and isoleucine degradation pathway; INTERACTS WITH 1,2-dimethylhydrazine; 2,2',4,4',5,5'-hexachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 3-ketoacyl-CoA thiolase A, peroxisomal; Ac; Acaa; Acaa1; acetyl-CoA acyltransferase A; beta-ketothiolase A; D9Ertd25; D9Ertd25e; MGC7090; P; peroxisomal 3-ketoacyl-CoA thiolase; peroxisomal 3-oxoacyl-CoA thiolase A; peroxisomal 3-oxoacyl-Coenzyme A thiolase; PTL; thiolase A
RGD Orthologs
Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399119,170,094 - 119,179,361 (+)NCBIGRCm39mm39
GRCm389119,341,028 - 119,350,296 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9119,339,676 - 119,350,299 (+)EnsemblGRCm38mm10GRCm38
MGSCv379119,250,412 - 119,259,413 (+)NCBIGRCm37mm9NCBIm37
MGSCv369119,189,992 - 119,198,993 (+)NCBImm8
Celera9119,810,424 - 119,819,473 (+)NCBICelera
Cytogenetic Map9F3NCBI
cM Map971.33NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
1,2-dimethylhydrazine  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
2-methyl-2-[4-(1,2,3,4-tetrahydronaphthalen-1-yl)phenoxy]propanoic acid  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (EXP)
3-chloropropane-1,2-diol  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4-amino-2,6-dinitrotoluene  (ISO)
aspartame  (EXP)
benzo[a]pyrene  (EXP)
bexarotene  (ISO)
bezafibrate  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
C60 fullerene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
captan  (EXP)
carbon nanotube  (EXP)
cerium trichloride  (EXP)
ciprofibrate  (EXP)
clobetasol  (EXP)
clofibrate  (EXP,ISO)
coumarin  (ISO)
dextran sulfate  (EXP)
dibutyl phthalate  (ISO)
dichloroacetic acid  (EXP)
diuron  (ISO)
doxorubicin  (ISO)
ethanol  (ISO)
fenofibrate  (EXP,ISO)
finasteride  (ISO)
flutamide  (ISO)
folic acid  (EXP)
folpet  (EXP)
furan  (ISO)
glafenine  (ISO)
leflunomide  (ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
monosodium L-glutamate  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
nafenopin  (ISO)
nefazodone  (ISO)
nimesulide  (ISO)
ochratoxin A  (ISO)
paracetamol  (EXP,ISO)
perfluorohexanesulfonic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanesulfonamide  (ISO)
perfluorooctanoic acid  (EXP,ISO)
permethrin  (EXP)
phenobarbital  (EXP)
pirinixic acid  (EXP,ISO)
pyrazinecarboxamide  (ISO)
resveratrol  (EXP)
rotenone  (ISO)
scopoletin  (ISO)
sodium dichromate  (EXP)
sodium fluoride  (EXP)
succimer  (EXP)
tamoxifen  (ISO)
Tesaglitazar  (ISO)
tetrachloroethene  (EXP)
tetrachloromethane  (EXP,ISO)
titanium dioxide  (EXP)
trichloroacetic acid  (EXP)
trichloroethene  (EXP)
troglitazone  (EXP,ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11171065   PMID:11217851   PMID:11461119   PMID:12477932   PMID:14610273   PMID:14681479   PMID:15043762  
PMID:15489334   PMID:15589695   PMID:15782199   PMID:16141072   PMID:16141073   PMID:17881773   PMID:18614015   PMID:21267068   PMID:21677750   PMID:21873635   PMID:22154759   PMID:23260145  
PMID:28378742   PMID:31040226   PMID:31666509   PMID:32325033  


Genomics

Comparative Map Data
Acaa1a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399119,170,094 - 119,179,361 (+)NCBIGRCm39mm39
GRCm389119,341,028 - 119,350,296 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9119,339,676 - 119,350,299 (+)EnsemblGRCm38mm10GRCm38
MGSCv379119,250,412 - 119,259,413 (+)NCBIGRCm37mm9NCBIm37
MGSCv369119,189,992 - 119,198,993 (+)NCBImm8
Celera9119,810,424 - 119,819,473 (+)NCBICelera
Cytogenetic Map9F3NCBI
cM Map971.33NCBI
Acaa1a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.08128,027,880 - 128,036,471 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8128,027,958 - 128,036,236 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08127,234,641 - 127,243,232 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48124,305,097 - 124,313,887 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.18124,324,833 - 124,333,624 (+)NCBI
Celera8118,231,008 - 118,239,798 (+)NCBICelera
Cytogenetic Map8q32NCBI

Position Markers
RH126000  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm389119,350,083 - 119,350,293UniSTSGRCm38
MGSCv379119,259,201 - 119,259,411UniSTSGRCm37
Celera9119,819,261 - 119,819,471UniSTS
Cytogenetic Map9F4UniSTS
cM Map971.0UniSTS
Whitehead/MRC_RH91179.61UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4141833W10q13_mweight 10 weeks QTL 13 (mouse)Not determined63332429120362868Mouse
4141545Tailaq2_mtail length adjusted QTL 2 (mouse)Not determined63332429120362868Mouse
1357635Splq4_mspleen weight QTL 4 (mouse)Not determined963332429120362868Mouse
1300549Bbaa17_mB. burgdorferi-associated arthritis 17 (mouse)Not determined986230401120230530Mouse
1302103Dob2_mdietary obesity 2 (mouse)Not determined986239845120289624Mouse
11251716Siim2_mstress induced immobility 2 (mouse)986748483120748483Mouse
12880422V25Dq6_mvitamin D inactive form serum level QTL 6 (mouse)987800000121800000Mouse
10412242Alpq8_malcohol preference QTL 8 (mouse)Not determined989284925123284925Mouse
1301649Psl1_mpromotion susceptibility QTL 1 (mouse)Not determined989412277123412396Mouse
18182932Metl3_mmetabolite locus 3, N-acetylglutamate (mouse)989563342123563342Mouse
12910770Splic1_mspleen iron content 1 (mouse)991413879124595110Mouse
12910772Lvic6_mliver iron content 6 (mouse)991413879124595110Mouse
12910773Splic3_mspleen iron content 3 (mouse)991413879124595110Mouse
1558767Skmw11_mskeletal muscle weight 11 (mouse)Not determined991641084124595110Mouse
13463474Hbbcq5_mhemoglobin concentration QTL 5 (mouse)991641084124595110Mouse
13463475Hctq7_mhematocrit QTL 7 (mouse)991641084124595110Mouse
13463477Rbc9_mred blood cell count 9 (mouse)991641084124595110Mouse
13463478Mchq18_mmean corpuscular hemoglobin QTL 18 (mouse)991641084124595110Mouse
13463480Mchcq2_mmean corpuscular hemoglobin concentration QTL 2 (mouse)991641084124595110Mouse
12904937Edlmmq9_mextensor digitorum longus muscle mass QTL 9 (mouse)991683173124595110Mouse
12904947Tammq7_mtibialis anterior muscle mass QTL 7 (mouse)991683173124595110Mouse
12904961Gmmq7_mgastrocnemius muscle mass QTL 7 (mouse)991683173124595110Mouse
1302001Bdln5_mbody length 5 (mouse)Not determined993762590124595110Mouse
1301484Bwq6_mbody weight (mouse)Not determined993762590124595110Mouse
14746992Manh67_mmandible shape 67 (mouse)994036768124595110Mouse
11537364Cnes5_mC. neoformans susceptibility locus 5 (mouse)996917590124595110Mouse
1301297Lcho1_mliver cholesterol 1 (mouse)Not determined9101060861124595110Mouse
1357627Tgq2_mtriglyceride QTL 2 (mouse)Not determined9102000187124595110Mouse
1357648Obq18_mobesity QTL 18 (mouse)Not determined9102000187124595110Mouse
1301789Pbwg4_mpostnatal body weight growth 4 (mouse)Not determined9103289445124595110Mouse
10412290Pvacm1l_mplasma vascular cell adhesion molecule 1 levels (mouse)Not determined9103289445124595110Mouse
12879896Berr3_mberghei resistance locus 3 (mouse)9103289445124595110Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1643
Count of miRNA genes:672
Interacting mature miRNAs:871
Transcripts:ENSMUST00000039784, ENSMUST00000175719, ENSMUST00000175743, ENSMUST00000175859, ENSMUST00000176007, ENSMUST00000176351, ENSMUST00000176397, ENSMUST00000176546, ENSMUST00000176796, ENSMUST00000177463
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000039784   ⟹   ENSMUSP00000042351
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9119,341,294 - 119,350,299 (+)Ensembl
RefSeq Acc Id: ENSMUST00000175719
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9119,348,505 - 119,349,036 (+)Ensembl
RefSeq Acc Id: ENSMUST00000175743   ⟹   ENSMUSP00000135439
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9119,341,515 - 119,350,033 (+)Ensembl
RefSeq Acc Id: ENSMUST00000175859
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9119,341,457 - 119,344,708 (+)Ensembl
RefSeq Acc Id: ENSMUST00000176007
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9119,346,098 - 119,348,755 (+)Ensembl
RefSeq Acc Id: ENSMUST00000176351   ⟹   ENSMUSP00000134926
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9119,339,676 - 119,342,752 (+)Ensembl
RefSeq Acc Id: ENSMUST00000176397   ⟹   ENSMUSP00000135191
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9119,341,515 - 119,350,033 (+)Ensembl
RefSeq Acc Id: ENSMUST00000176546   ⟹   ENSMUSP00000134981
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9119,342,773 - 119,349,526 (+)Ensembl
RefSeq Acc Id: ENSMUST00000176796
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9119,341,414 - 119,350,298 (+)Ensembl
RefSeq Acc Id: ENSMUST00000177463   ⟹   ENSMUSP00000135310
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9119,341,047 - 119,347,783 (+)Ensembl
RefSeq Acc Id: NM_001357516   ⟹   NP_001344445
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399119,170,360 - 119,179,361 (+)NCBI
GRCm389119,341,294 - 119,350,295 (+)NCBI
Sequence:
RefSeq Acc Id: NM_130864   ⟹   NP_570934
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399119,170,360 - 119,179,361 (+)NCBI
GRCm389119,341,294 - 119,350,295 (+)NCBI
MGSCv379119,250,412 - 119,259,413 (+)RGD
Celera9119,810,424 - 119,819,473 (+)RGD
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006511923   ⟹   XP_006511986
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399119,170,094 - 119,179,361 (+)NCBI
GRCm389119,341,028 - 119,350,296 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030244018   ⟹   XP_030099878
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399119,170,199 - 119,179,361 (+)NCBI
GRCm389119,341,133 - 119,350,296 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030244019   ⟹   XP_030099879
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399119,170,113 - 119,179,361 (+)NCBI
GRCm389119,341,047 - 119,350,296 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_570934   ⟸   NM_130864
- Peptide Label: isoform 1 precursor
- UniProtKB: Q921H8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006511986   ⟸   XM_006511923
- Peptide Label: isoform X1
- UniProtKB: Q921H8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_030099879   ⟸   XM_030244019
- Peptide Label: isoform X1
RefSeq Acc Id: XP_030099878   ⟸   XM_030244018
- Peptide Label: isoform X1
RefSeq Acc Id: NP_001344445   ⟸   NM_001357516
- Peptide Label: isoform 2
RefSeq Acc Id: ENSMUSP00000135310   ⟸   ENSMUST00000177463
RefSeq Acc Id: ENSMUSP00000042351   ⟸   ENSMUST00000039784
RefSeq Acc Id: ENSMUSP00000135191   ⟸   ENSMUST00000176397
RefSeq Acc Id: ENSMUSP00000134926   ⟸   ENSMUST00000176351
RefSeq Acc Id: ENSMUSP00000134981   ⟸   ENSMUST00000176546
RefSeq Acc Id: ENSMUSP00000135439   ⟸   ENSMUST00000175743
Protein Domains
Thiolase_C   Thiolase_N

Promoters
RGD ID:6844055
Promoter ID:MM_KWN:59131
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Spleen
Transcripts:ENSMUST00000063335,   NM_130864
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv369119,249,436 - 119,250,602 (+)MPROMDB
RGD ID:6848370
Promoter ID:MM_ACW:52402
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_4Hour
Transcripts:ACAA1A.FSEP07-UNSPLICED,   ACAA1A.HSEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv369119,257,486 - 119,257,986 (+)MPROMDB
RGD ID:8671190
Promoter ID:EPDNEW_M13626
Type:initiation region
Name:Acaa1a_1
Description:Mus musculus acetyl-Coenzyme A acyltransferase 1A , transcriptvariant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm389119,341,355 - 119,341,415EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2148491 AgrOrtholog
Ensembl Genes ENSMUSG00000036138 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000042351 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000134926 UniProtKB/TrEMBL
  ENSMUSP00000134981 UniProtKB/TrEMBL
  ENSMUSP00000135191 UniProtKB/TrEMBL
  ENSMUSP00000135310 UniProtKB/TrEMBL
  ENSMUSP00000135439 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000039784 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000175743 UniProtKB/TrEMBL
  ENSMUST00000176351 UniProtKB/TrEMBL
  ENSMUST00000176397 UniProtKB/TrEMBL
  ENSMUST00000176546 UniProtKB/TrEMBL
  ENSMUST00000177463 UniProtKB/TrEMBL
Gene3D-CATH 3.40.47.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Thiolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thiolase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thiolase_acyl_enz_int_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thiolase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thiolase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thiolase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thiolase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:113868 UniProtKB/Swiss-Prot
MGD MGI:2148491 ENTREZGENE
NCBI Gene 113868 ENTREZGENE
Pfam Thiolase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thiolase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Acaa1a PhenoGen
PIRSF Ac-CoA_Ac_transf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE THIOLASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THIOLASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THIOLASE_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF53901 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs AcCoA-C-Actrans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Mm.205266 ENTREZGENE
UniProt H3BJC1_MOUSE UniProtKB/TrEMBL
  H3BJG8_MOUSE UniProtKB/TrEMBL
  H3BJZ9_MOUSE UniProtKB/TrEMBL
  H3BKA1_MOUSE UniProtKB/TrEMBL
  H3BKL5_MOUSE UniProtKB/TrEMBL
  Q3UPU8_MOUSE UniProtKB/TrEMBL
  Q8BLD7_MOUSE UniProtKB/TrEMBL
  Q8R343_MOUSE UniProtKB/TrEMBL
  Q921H8 ENTREZGENE, UniProtKB/Swiss-Prot