Havcr1 (hepatitis A virus cellular receptor 1) - Rat Genome Database

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Gene: Havcr1 (hepatitis A virus cellular receptor 1) Mus musculus
Analyze
Symbol: Havcr1
Name: hepatitis A virus cellular receptor 1
RGD ID: 1553522
MGI Page MGI
Description: Enables phosphatidylserine binding activity. Acts upstream of or within positive regulation of mast cell activation; response to lipopolysaccharide; and response to wounding. Located in brush border and cell surface. Is expressed in aorta-gonad-mesonephros; brain; gonad; liver; and lung. Human ortholog(s) of this gene implicated in atopic dermatitis. Orthologous to human HAVCR1 (hepatitis A virus cellular receptor 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AI503787; HAVcr-1; hepatitis A virus cellular receptor 1 homolog; kidney injury molecule 1; KIM-; KIM-1; t cell immunoglobulin and mucin domain-containing protein 1; t cell membrane protein 1; T-cell immunoglobulin and mucin domain containing 1; T-cell immunoglobulin mucin receptor 1; Tim; TIM-; TIM-1; Tim1; TIMD-1; Timd1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391146,630,644 - 46,670,405 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1146,625,907 - 46,670,405 (+)EnsemblGRCm39 Ensembl
GRCm381146,739,822 - 46,779,578 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1146,735,080 - 46,779,578 (+)EnsemblGRCm38mm10GRCm38
MGSCv371146,553,725 - 46,593,080 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361146,594,600 - 46,622,036 (+)NCBIMGSCv36mm8
Celera1151,321,716 - 51,355,068 (+)NCBICelera
Cytogenetic Map11B1.1NCBI
cM Map1128.08NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-lipoic acid  (ISO)
(S)-naringenin  (EXP)
(S)-nicotine  (EXP)
1-naphthyl isothiocyanate  (ISO)
11-deoxycorticosterone  (ISO)
17beta-estradiol 3-benzoate  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-methyladenine  (ISO)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (EXP)
acrylamide  (ISO)
adefovir  (ISO)
adenine  (EXP)
aflatoxin B1  (ISO)
agomelatine  (ISO)
aldehydo-D-glucose  (EXP)
allyl alcohol  (ISO)
amlodipine  (ISO)
ammonium chloride  (ISO)
amphotericin B methyl ester  (EXP)
anthocyanin  (ISO)
anthracen-2-amine  (ISO)
aristolochic acid A  (EXP,ISO)
arotinoid acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
bacitracin  (ISO)
benzo[a]pyrene  (ISO)
Bergenin  (ISO)
Bisibuthiamine  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP)
boric acid  (ISO)
boron atom  (ISO)
butanal  (ISO)
C60 fullerene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
canagliflozin  (ISO)
catalpol  (EXP)
cefaloridine  (ISO)
CGP 52608  (ISO)
CHIR 99021  (ISO)
chlordecone  (EXP)
chloroform  (ISO)
cholesterol  (ISO)
chromium atom  (ISO)
chromium(6+)  (ISO)
cidofovir anhydrous  (ISO)
cilnidipine  (ISO)
cisplatin  (EXP,ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cortisol  (ISO)
curcumin  (ISO)
cyanocob(III)alamin  (EXP,ISO)
cyanuric acid  (ISO)
cyclosporin A  (EXP,ISO)
D-glucose  (EXP)
dapagliflozin  (ISO)
deferasirox  (EXP,ISO)
desferrioxamine B  (ISO)
Di-n-octyl phthalate  (ISO)
diclofenac  (ISO)
doxorubicin  (ISO)
elemental boron  (ISO)
erythrosin B  (ISO)
ethanol  (EXP)
ethylene glycol  (ISO)
ethylparaben  (ISO)
fenamic acid  (ISO)
ferrostatin-1  (EXP)
folic acid  (EXP,ISO)
formaldehyde  (ISO)
formononetin  (ISO)
fructose  (EXP,ISO)
galangin  (ISO)
gefitinib  (EXP)
gentamycin  (ISO)
geraniol  (ISO)
glucose  (EXP)
glycidol  (EXP)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
hesperidin  (ISO)
Hexachloro-1,3-butadiene  (ISO)
hydrogen chloride  (EXP)
hydrogen peroxide  (ISO)
icosanoid  (ISO)
inositol  (EXP)
iodixanol  (ISO)
iohexol  (ISO)
iron(III) nitrilotriacetate  (ISO)
isocyanuric acid  (ISO)
isoliquiritigenin  (ISO)
isoniazide  (ISO)
ketamine  (EXP)
ketoconazole  (ISO)
L-ascorbic acid  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
lidocaine  (ISO)
linoleic acid  (ISO)
lipoic acid  (ISO)
lipopolysaccharide  (EXP,ISO)
lisinopril dihydrate  (ISO)
losartan  (ISO)
madecassoside  (EXP)
maleic acid  (ISO)
meglumine amidotrizoate  (ISO)
melamine  (ISO)
melatonin  (EXP)
menadione  (ISO)
mercury atom  (ISO)
mercury dichloride  (EXP,ISO)
mercury(0)  (ISO)
metformin  (ISO)
methamphetamine  (EXP)
methylmercury chloride  (EXP,ISO)
N-acetyl-L-cysteine  (ISO)
N-nitrosodiethylamine  (ISO)
natamycin  (EXP)
nicorandil  (ISO)
nicotine  (EXP)
nifedipine  (ISO)
nitric oxide  (ISO)
nitrofen  (ISO)
nystatin  (EXP)
ochratoxin A  (EXP,ISO)
oleic acid  (ISO)
Ondansetron  (EXP)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
patulin  (ISO)
Pentoxifylline  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenol  (ISO)
phenylbutazone  (ISO)
phenylmercury acetate  (ISO)
Phytolaccoside E  (EXP,ISO)
pinostrobin  (ISO)
pirinixic acid  (EXP)
polymyxin B2  (ISO)
potassium bromate  (ISO)
potassium dichromate  (ISO)
probenecid  (ISO)
resveratrol  (EXP)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
salubrinal  (EXP)
SB 431542  (ISO)
sirolimus  (ISO)
sodium arsenite  (EXP,ISO)
sodium cholate  (ISO)
sodium fluoride  (ISO)
streptozocin  (EXP,ISO)
sulforaphane  (EXP)
tacrolimus hydrate  (ISO)
tannic acid  (ISO)
tartrazine  (ISO)
tenofovir disoproxil fumarate  (ISO)
testosterone  (EXP,ISO)
tetrachloroethene  (EXP)
tetrachloromethane  (EXP,ISO)
tetramethylpyrazine  (ISO)
thioacetamide  (ISO)
trichloroethene  (ISO)
umbelliferone  (ISO)
urethane  (ISO)
vancomycin  (EXP,ISO)
vildagliptin  (ISO)
XAV939  (ISO)
xylazine  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Urinary NGAL and KIM-1: biomarkers for assessment of acute ischemic kidney injury following nephron sparing surgery. Abassi Z, etal., J Urol. 2013 Apr;189(4):1559-66. doi: 10.1016/j.juro.2012.10.029. Epub 2012 Oct 22.
2. Macrophage infiltration and renal damage are independent of matrix metalloproteinase 12 in the obstructed kidney. Abraham AP, etal., Nephrology (Carlton). 2012 May;17(4):322-9. doi: 10.1111/j.1440-1797.2012.01567.x.
3. Early urinary and plasma biomarkers for experimental diabetic nephropathy. Alter ML, etal., Clin Lab. 2012;58(7-8):659-71.
4. Fructose induces tubulointerstitial injury in the kidney of mice. Aoyama M, etal., Biochem Biophys Res Commun. 2012 Mar 9;419(2):244-9. doi: 10.1016/j.bbrc.2012.02.001. Epub 2012 Feb 8.
5. Urinary kidney injury molecule 1 and incidence of heart failure in elderly men. Carlsson AC, etal., Eur J Heart Fail. 2013 Apr;15(4):441-6. doi: 10.1093/eurjhf/hfs187. Epub 2012 Dec 7.
6. Hepatitis A virus cellular receptor 1/kidney injury molecule-1 is a susceptibility gene for clear cell renal cell carcinoma and hepatitis A virus cellular receptor/kidney injury molecule-1 ectodomain shedding a predictive biomarker of tumour progression. Cuadros T, etal., Eur J Cancer. 2013 May;49(8):2034-47. doi: 10.1016/j.ejca.2012.12.020. Epub 2013 Jan 23.
7. Chronic renovascular hypertension is associated with elevated levels of neutrophil gelatinase-associated lipocalin. Eirin A, etal., Nephrol Dial Transplant. 2012 Nov;27(11):4153-61. doi: 10.1093/ndt/gfs370. Epub 2012 Aug 23.
8. Changes of the tubular markers in type 2 diabetes mellitus with glomerular hyperfiltration. Fu WJ, etal., Diabetes Res Clin Pract. 2012 Jan;95(1):105-9. doi: 10.1016/j.diabres.2011.09.031. Epub 2011 Oct 20.
9. [Clinical study of kidney injury molecule-1 in the treatment of sepsis patients]. Gao LL, etal., Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2012 Nov;24(11):647-50.
10. Structural equation modeling highlights the potential of Kim-1 as a biomarker for chronic kidney disease. Gardiner L, etal., Am J Nephrol. 2012;35(2):152-63. doi: 10.1159/000335579. Epub 2012 Jan 20.
11. Association of atopy and eczema with polymorphisms in T-cell immunoglobulin domain and mucin domain-IL-2-inducible T-cell kinase gene cluster in chromosome 5 q 33. Graves PE, etal., J Allergy Clin Immunol. 2005 Sep;116(3):650-6.
12. Kidney Injury Molecule-1 (KIM-1): a novel biomarker for human renal proximal tubule injury. Han WK, etal., Kidney Int. 2002 Jul;62(1):237-44.
13. Urinary macrophage migration inhibitory factor serves as a potential biomarker for acute kidney injury in patients with acute pyelonephritis. Hong MY, etal., Mediators Inflamm. 2012;2012:381358. doi: 10.1155/2012/381358. Epub 2012 Dec 23.
14. Early detection of renal injury using urinary vanin-1 in rats with experimental colitis. Hosohata K, etal., J Appl Toxicol. 2013 Jan 11. doi: 10.1002/jat.2849.
15. Kidney injury molecule-1 and osteopontin: new markers for prediction of early kidney transplant rejection. Jin ZK, etal., Mol Immunol. 2013 Jul;54(3-4):457-64. doi: 10.1016/j.molimm.2013.01.013. Epub 2013 Feb 27.
16. T Cell Ig- and mucin-domain-containing molecule-3 (TIM-3) and TIM-1 molecules are differentially expressed on human Th1 and Th2 cells and in cerebrospinal fluid-derived mononuclear cells in multiple sclerosis. Khademi M, etal., J Immunol. 2004 Jun 1;172(11):7169-76.
17. Kidney injury molecule-1 is up-regulated in renal epithelial cells in response to oxalate in vitro and in renal tissues in response to hyperoxaluria in vivo. Khandrika L, etal., PLoS One. 2012;7(9):e44174. doi: 10.1371/journal.pone.0044174. Epub 2012 Sep 12.
18. Effect of combining ACE inhibition with aldosterone blockade on proteinuria and renal damage in experimental nephrosis. Kramer AB, etal., Kidney Int. 2007 Mar;71(5):417-24. Epub 2007 Jan 10.
19. Kidney injury molecule-1 expression in murine polycystic kidney disease. Kuehn EW, etal., Am J Physiol Renal Physiol. 2002 Dec;283(6):F1326-36. Epub 2002 Jul 24.
20. KIM-1 expression predicts renal outcomes in IgA nephropathy. Kwon SH, etal., Clin Exp Nephrol. 2012 Nov 8.
21. Myocardial infarction impairs renal function, induces renal interstitial fibrosis, and increases renal KIM-1 expression: implications for cardiorenal syndrome. Lekawanvijit S, etal., Am J Physiol Heart Circ Physiol. 2012 May 1;302(9):H1884-93. doi: 10.¿1152/¿ajpheart.¿00967.¿2011. Epub 2012 Feb 24.
22. Urinary Biomarkers in Relapsing Antineutrophil Cytoplasmic Antibody-associated Vasculitis. Lieberthal JG, etal., J Rheumatol. 2013 May;40(5):674-683. Epub 2013 Apr 1.
23. MGDs mouse GO annotations MGD data from the GO Consortium
24. Vitamin D and calcium co-therapy mitigates pre-established cadmium nephropathy by regulating renal calcium homeostatic molecules and improving anti-oxidative and anti-inflammatory activities in rat. Obaid AA, etal., J Trace Elem Med Biol. 2023 May 24;79:127221. doi: 10.1016/j.jtemb.2023.127221.
25. Bilirubin attenuates the renal tubular injury by inhibition of oxidative stress and apoptosis. Oh SW, etal., BMC Nephrol. 2013 May 17;14(1):105.
26. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
27. High urinary excretion of kidney injury molecule-1 is an independent predictor of end-stage renal disease in patients with IgA nephropathy. Peters HP, etal., Nephrol Dial Transplant. 2011 Nov;26(11):3581-8. doi: 10.1093/ndt/gfr135. Epub 2011 Apr 5.
28. Cardiotrophin-1 administration prevents the renal toxicity of iodinated contrast media in rats. Quiros Y, etal., Toxicol Sci. 2013 Apr;132(2):493-501. doi: 10.1093/toxsci/kft007. Epub 2013 Jan 18.
29. Mouse MP Annotation Import Pipeline RGD automated import pipeline
30. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
31. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
32. Kidney injury biomarkers in hypertensive, diabetic, and nephropathy rat models treated with contrast media. Rouse RL, etal., Toxicol Pathol. 2013;41(4):662-80. doi: 10.1177/0192623312464122. Epub 2012 Oct 19.
33. Novel assays for detection of urinary KIM-1 in mouse models of kidney injury. Sabbisetti VS, etal., Toxicol Sci. 2013 Jan;131(1):13-25. doi: 10.1093/toxsci/kfs268. Epub 2012 Sep 27.
34. Selenium inhibits renal oxidation and inflammation but not acute kidney injury in an animal model of rhabdomyolysis. Shanu A, etal., Antioxid Redox Signal. 2013 Mar 1;18(7):756-69. doi: 10.1089/ars.2012.4591. Epub 2012 Oct 16.
35. Protective Role of Testosterone in Ischemia-Reperfusion-induced Acute Kidney Injury. Soljancic A, etal., Am J Physiol Regul Integr Comp Physiol. 2013 Apr 3.
36. Antagonism of TIM-1 blocks the development of disease in a humanized mouse model of allergic asthma. Sonar SS, etal., J Clin Invest. 2010 Aug 2;120(8):2767-81. doi: 10.1172/JCI39543. Epub 2010 Jul 12.
37. Biomarkers for early detection of sickle nephropathy. Sundaram N, etal., Am J Hematol. 2011 Jul;86(7):559-66. doi: 10.1002/ajh.22045. Epub 2011 May 31.
38. Is urinary kidney injury molecule-1 a noninvasive marker for renal scarring in children with vesicoureteral reflux? Toker A, etal., Urology. 2013 Jan;81(1):168-72. doi: 10.1016/j.urology.2012.09.004. Epub 2012 Nov 30.
39. Urine NGAL and KIM-1 in children and adolescents with hyperuricemia. Tomczak J, etal., Pediatr Nephrol. 2013 May 15.
40. Regression of microalbuminuria in type 1 diabetes is associated with lower levels of urinary tubular injury biomarkers, kidney injury molecule-1, and N-acetyl-beta-D-glucosaminidase. Vaidya VS, etal., Kidney Int. 2011 Feb;79(4):464-70. doi: 10.1038/ki.2010.404. Epub 2010 Oct 27.
41. Tubular kidney injury molecule-1 in protein-overload nephropathy. van Timmeren MM, etal., Am J Physiol Renal Physiol. 2006 Aug;291(2):F456-64. Epub 2006 Feb 7.
42. Comprehensive Molecular Analyses of a Macrophage-Related Gene Signature With Regard to Prognosis, Immune Features, and Biomarkers for Immunotherapy in Hepatocellular Carcinoma Based on WGCNA and the LASSO Algorithm. Wang T, etal., Front Immunol. 2022 May 27;13:843408. doi: 10.3389/fimmu.2022.843408. eCollection 2022.
43. KIM-1 and NGAL: new markers of obstructive nephropathy. Wasilewska A, etal., Pediatr Nephrol. 2011 Apr;26(4):579-86. doi: 10.1007/s00467-011-1773-5. Epub 2011 Jan 31.
Additional References at PubMed
PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11544199   PMID:11725301   PMID:12466851   PMID:12477932   PMID:14534576   PMID:15489334   PMID:15793575  
PMID:15793576   PMID:16141072   PMID:16141073   PMID:16284246   PMID:17145500   PMID:17277130   PMID:17363299   PMID:17513880   PMID:17606630   PMID:17620455   PMID:17915221   PMID:17960135  
PMID:18079964   PMID:18082433   PMID:18083575   PMID:18172549   PMID:18234236   PMID:19155484   PMID:19528638   PMID:20091883   PMID:20181666   PMID:20220086   PMID:20518819   PMID:20562862  
PMID:20566714   PMID:20889552   PMID:21303660   PMID:21355054   PMID:21469101   PMID:21470319   PMID:21677750   PMID:21821911   PMID:21835770   PMID:21873635   PMID:21923683   PMID:22144095  
PMID:22205357   PMID:22773818   PMID:23137033   PMID:23672783   PMID:23979159   PMID:24316337   PMID:24453431   PMID:24551271   PMID:24623145   PMID:24703780   PMID:24829508   PMID:24904085  
PMID:25582854   PMID:25645598   PMID:25751064   PMID:25759266   PMID:26282792   PMID:26311113   PMID:26697979   PMID:26726878   PMID:26821944   PMID:27028054   PMID:27296697   PMID:27591740  
PMID:28874468   PMID:28949386   PMID:28951472   PMID:28978444   PMID:29074644   PMID:29402223   PMID:29595914   PMID:30938680   PMID:31242184   PMID:32668241   PMID:33211259   PMID:33612466  
PMID:33951465   PMID:34088927   PMID:34151589   PMID:34675931   PMID:34843572   PMID:35073759   PMID:35296554   PMID:35636144   PMID:35922481   PMID:35982620   PMID:36522157   PMID:37460623  


Genomics

Comparative Map Data
Havcr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391146,630,644 - 46,670,405 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1146,625,907 - 46,670,405 (+)EnsemblGRCm39 Ensembl
GRCm381146,739,822 - 46,779,578 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1146,735,080 - 46,779,578 (+)EnsemblGRCm38mm10GRCm38
MGSCv371146,553,725 - 46,593,080 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361146,594,600 - 46,622,036 (+)NCBIMGSCv36mm8
Celera1151,321,716 - 51,355,068 (+)NCBICelera
Cytogenetic Map11B1.1NCBI
cM Map1128.08NCBI
HAVCR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385157,029,413 - 157,069,407 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5157,026,742 - 157,069,396 (-)EnsemblGRCh38hg38GRCh38
GRCh375156,456,424 - 156,486,127 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365156,389,109 - 156,418,065 (-)NCBINCBI36Build 36hg18NCBI36
Build 345156,389,014 - 156,418,548NCBI
Celera5152,482,103 - 152,511,651 (-)NCBICelera
Cytogenetic Map5q33.3NCBI
HuRef5151,544,985 - 151,574,299 (-)NCBIHuRef
CHM1_15155,888,935 - 155,918,725 (-)NCBICHM1_1
T2T-CHM13v2.05157,548,433 - 157,588,641 (-)NCBIT2T-CHM13v2.0
Havcr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81031,619,914 - 31,652,955 (+)NCBIGRCr8
mRatBN7.21031,118,667 - 31,151,730 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1031,119,088 - 31,151,698 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1035,844,047 - 35,867,236 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0104,382,417 - 4,405,608 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01030,831,210 - 30,854,422 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01031,813,819 - 31,860,934 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1031,813,814 - 31,848,379 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01031,632,718 - 31,682,172 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41031,834,519 - 31,858,019 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11031,835,567 - 31,859,066 (+)NCBI
Celera1030,573,361 - 30,596,533 (+)NCBICelera
Cytogenetic Map10q21NCBI
Havcr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495540811,047,679 - 11,070,492 (-)NCBIChiLan1.0ChiLan1.0
HAVCR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24152,220,695 - 152,257,458 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15150,360,242 - 150,397,005 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05152,429,337 - 152,459,800 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15158,413,054 - 158,442,481 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5158,413,073 - 158,442,481 (-)Ensemblpanpan1.1panPan2
HAVCR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1453,012,223 - 53,066,611 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl453,046,970 - 53,128,952 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl453,012,234 - 53,033,393 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha452,939,224 - 52,956,256 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0453,479,175 - 53,503,280 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl453,456,833 - 53,570,712 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1453,309,862 - 53,326,891 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0453,416,885 - 53,433,922 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0453,933,785 - 53,950,850 (+)NCBIUU_Cfam_GSD_1.0
Havcr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213107,580,999 - 107,601,858 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365156,030,402 - 6,051,161 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HAVCR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11666,162,318 - 66,208,868 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21671,949,487 - 71,963,277 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HAVCR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12359,422,769 - 59,454,183 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2359,423,334 - 59,453,531 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603418,176,581 - 18,208,543 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Havcr1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473332,284,793 - 32,310,980 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Havcr1
1960 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:833
Count of miRNA genes:260
Interacting mature miRNAs:296
Transcripts:ENSMUST00000047568, ENSMUST00000081819, ENSMUST00000109223, ENSMUST00000109224
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226798Scvln18_msacral vertebrae length 2, 16 week (mouse)11325000060690826Mouse
26884446Sklq10_mskull length QTL 10, 10 week (mouse)11325000062890826Mouse
26884453Sklq16_mskull length QTL 16, 16 week (mouse)11325000072690826Mouse
13208559Wght10_mweight 10 (mouse)11395000088890826Mouse
13208558Lgth12_mbody length 12 (mouse)11395000094890826Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11688027789019734Mouse
27226738Metcl11_mmetatarsal-calcaneal length 11, 10 week (mouse)11885000061390826Mouse
26884401Huml4_mhumerus length 4, 10 week (mouse)111155000068490826Mouse
27226762Feml21_mfemur length 21, 16 week (mouse)111175000065990826Mouse
1357640Orq2_movulation rate QTL 2 (mouse)Not determined111226863768500330Mouse
4141127W3q4_mweight 3 weeks QTL 4 (mouse)Not determined1226863768500330Mouse
4141470Egq4_mearly growth QTL 4 (mouse)Not determined1226863768500330Mouse
4142109W10q2_mweight 10 weeks QTL 2 (mouse)Not determined1226863768500330Mouse
4141582Lgaq1_mlate growth adjusted QTL 1 (mouse)Not determined1226863768500330Mouse
4142308W6q3_mweight 6 weeks QTL 3 (mouse)Not determined111226863768500330Mouse
4142216Lgq1_mlate growth QTL 1 (mouse)Not determined1226863768500330Mouse
4141966Tailq1_mtail length QTL 1 (mouse)Not determined1226863768500330Mouse
1357851Scfq3_msubcutaneous fat pad weight QTL 3 (mouse)Not determined111226863768500330Mouse
1357720Kidpq1_mkidney weight percentage QTL 1 (mouse)Not determined111226863768500330Mouse
1357437Epfq4_mepididymal fat pad weight QTL 4 (mouse)Not determined111226863768500330Mouse
1559002Lmrq4_mLeishmania major resistance QTL 4 (mouse)Not determined111226863769684947Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
1558945Orgwq8_morgan weight QTL 8 (mouse)Not determined111705617567078411Mouse
10053687Eae6_msusceptibility to experimental allergic encephalomyelitis 6 (mouse)Not determined111778196668500330Mouse
12801459Leuf1_mleukocyte filtration 1 (mouse)111857861652578716Mouse
12801460Intim2_mintima modifier 2 (mouse)111857861652578716Mouse
12801457Intmrm2_mintima/media ratio modifier 2 (mouse)111857861652578716Mouse
1300938Bulb3_mbulb size 3 (mouse)Not determined111857861652578716Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1912420496897826Mouse
1300579Thypr1_mthymocyte proliferative response 1 (mouse)Not determined111928257753282715Mouse
14746971Manh70_mmandible shape 70 (mouse)111990589053905890Mouse
4141398Tgq22_mtriglyceride QTL 22 (mouse)Not determined2116340655163406Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112180736495881231Mouse
10044006Hbnr13_mHeligmosomoides bakeri nematode resistance 13 (mouse)Not determined112577262659772741Mouse
12910801Pwbwq14_mpost-weaning body weight QTL 14 (mouse)112719805750636094Mouse
12910804Pwbwq16_mpost-weaning body weight QTL 16 (mouse)112719805750636094Mouse
12910806Pwbwq15_mpost-weaning body weight QTL 15 (mouse)112719805750636094Mouse
12910817Pwgrq20_mpost-weaning growth rate QTL 20 (mouse)112719805750636094Mouse
12910818Ogrq5_moverall growth rate QTL 5 (mouse)112719805750636094Mouse
1357844Si5lq5_mserum IGFBP-5 level QTL 5 (mouse)Not determined112816587362165976Mouse
13524848Ppiq7_mprepulse inhibition QTL 7 (mouse)112856914762569147Mouse
1301426Desp2_mdespair 2 (mouse)Not determined112870858162708700Mouse
11522752Cocia18_mcocaine-induced activity, QTL 18 (mouse)113100820965008209Mouse
11059563Lmr31_mleishmaniasis resistance 31 (mouse)113210057766100694Mouse
1357782Char8_mP. chabaudi malaria resistance QTL 8 (mouse)Not determined113557861669684987Mouse
13208569Bmiq10_mbody mass index QTL 10 (mouse)113589082784890826Mouse
1301328Mol4_mmodifier of LPS-response 4 (mouse)Not determined113628257783481356Mouse
1301788Lbw8_mlupus NZB x NZW 8 (mouse)Not determined113650328770509492Mouse
1301896Tria1_mT-cell receptor induced activation 1 (mouse)Not determined113661356570613855Mouse
4141853Skmw17_mskeletal muscle weight 17 (mouse)Not determined113708094171081064Mouse
4142475Ity2a_mimmunity to S. typhimurium 2a (mouse)Not determined113776858060402716Mouse
10766457Nwa3_mNew Zealand White autoimmunity 3 (mouse)113801611572016209Mouse
10053675Eae44b_mexperimental allergic encephalomyelitis susceptibility 44b (mouse)Not determined113995072854094448Mouse
11532698Sluc36a_msusceptibility to lung cancer 36a (mouse)114225661776256730Mouse
11532699Sluc36b_msusceptibility to lung cancer 36b (mouse)114225661776256730Mouse
1300713Vmbic10_mventral midbrain iron content 10 (mouse)Not determined114277262654081064Mouse
4142300Ctrq3_mC. trachomatis resistance QTL 3 (mouse)Not determined114463003876854757Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44630038113058009Mouse
1302021Nidd1n_mnon-insulin-dependent diabetes mellitus 1 in NSY (mouse)Not determined114516587379978324Mouse
1357878Mastr_mmodifier of astrocytoma (mouse)Not determined114570858189818733Mouse
1300765Bbaa4_mB.burgdorferi-associated arthritis 4 (mouse)Not determined114618516780185262Mouse
1301988Bmd11_mbone mineral density 11 (mouse)Not determined114631940780319522Mouse

Markers in Region
AI503787  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381146,779,230 - 46,779,403UniSTSGRCm38
MGSCv371146,592,732 - 46,592,905UniSTSGRCm37
Celera1151,354,720 - 51,354,893UniSTS
Cytogenetic Map11B1.1UniSTS
Whitehead/MRC_RH11628.32UniSTS
Timd1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381146,690,858 - 46,691,234UniSTSGRCm38
GRCm381146,749,895 - 46,750,266UniSTSGRCm38
MGSCv371146,504,360 - 46,504,736UniSTSGRCm37
MGSCv371146,563,397 - 46,563,768UniSTSGRCm37
Celera1151,331,384 - 51,331,751UniSTS
Celera1151,278,904 - 51,279,280UniSTS
Cytogenetic Map11B1.1UniSTS
cM Map11 UniSTS
cM MapUN UniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000047568   ⟹   ENSMUSP00000043827
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1146,641,995 - 46,670,405 (+)Ensembl
GRCm38.p6 Ensembl1146,751,168 - 46,779,578 (+)Ensembl
RefSeq Acc Id: ENSMUST00000081819   ⟹   ENSMUSP00000080503
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1146,630,888 - 46,670,405 (+)Ensembl
GRCm38.p6 Ensembl1146,740,061 - 46,779,578 (+)Ensembl
RefSeq Acc Id: ENSMUST00000109223   ⟹   ENSMUSP00000104846
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1146,641,338 - 46,670,403 (+)Ensembl
GRCm38.p6 Ensembl1146,750,511 - 46,779,576 (+)Ensembl
RefSeq Acc Id: ENSMUST00000109224   ⟹   ENSMUSP00000104847
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1146,625,907 - 46,647,072 (+)Ensembl
GRCm38.p6 Ensembl1146,735,080 - 46,756,245 (+)Ensembl
RefSeq Acc Id: NM_001166631   ⟹   NP_001160103
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391146,641,338 - 46,670,405 (+)NCBI
GRCm381146,750,511 - 46,779,578 (+)NCBI
MGSCv371146,553,725 - 46,593,080 (+)RGD
Celera1151,321,716 - 51,355,068 (+)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001166632   ⟹   NP_001160104
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391146,631,050 - 46,670,405 (+)NCBI
GRCm381146,740,223 - 46,779,578 (+)NCBI
MGSCv371146,553,725 - 46,593,080 (+)RGD
Celera1151,321,716 - 51,355,068 (+)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_134248   ⟹   NP_599009
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391146,641,995 - 46,670,405 (+)NCBI
GRCm381146,751,168 - 46,779,578 (+)NCBI
MGSCv371146,553,725 - 46,593,080 (+)RGD
Celera1151,321,716 - 51,355,068 (+)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006532392   ⟹   XP_006532455
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391146,630,644 - 46,670,401 (+)NCBI
GRCm381146,739,822 - 46,779,574 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006532393   ⟹   XP_006532456
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391146,630,644 - 46,670,405 (+)NCBI
GRCm381146,739,822 - 46,779,578 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011248783   ⟹   XP_011247085
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391146,641,333 - 46,670,401 (+)NCBI
GRCm381146,750,506 - 46,779,574 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011248784   ⟹   XP_011247086
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391146,630,644 - 46,670,401 (+)NCBI
GRCm381146,739,822 - 46,779,574 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030245623   ⟹   XP_030101483
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391146,641,323 - 46,670,405 (+)NCBI
GRCm381146,750,498 - 46,779,578 (+)NCBI
Sequence:
RefSeq Acc Id: NP_599009   ⟸   NM_134248
- Peptide Label: isoform a precursor
- UniProtKB: Q8VIM2 (UniProtKB/Swiss-Prot),   Q8VIM1 (UniProtKB/Swiss-Prot),   Q7TPU2 (UniProtKB/Swiss-Prot),   Q5QNS5 (UniProtKB/Swiss-Prot),   A0A0A0MQ86 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001160104   ⟸   NM_001166632
- Peptide Label: isoform b precursor
- UniProtKB: Q8VIM2 (UniProtKB/Swiss-Prot),   Q8VIM1 (UniProtKB/Swiss-Prot),   Q7TPU2 (UniProtKB/Swiss-Prot),   Q5QNS5 (UniProtKB/Swiss-Prot),   Q3V033 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001160103   ⟸   NM_001166631
- Peptide Label: isoform b precursor
- UniProtKB: Q8VIM2 (UniProtKB/Swiss-Prot),   Q8VIM1 (UniProtKB/Swiss-Prot),   Q7TPU2 (UniProtKB/Swiss-Prot),   Q5QNS5 (UniProtKB/Swiss-Prot),   Q3V033 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006532456   ⟸   XM_006532393
- Peptide Label: isoform X2
- UniProtKB: Q8VIM2 (UniProtKB/Swiss-Prot),   Q8VIM1 (UniProtKB/Swiss-Prot),   Q7TPU2 (UniProtKB/Swiss-Prot),   Q5QNS5 (UniProtKB/Swiss-Prot),   A0A0A0MQ86 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006532455   ⟸   XM_006532392
- Peptide Label: isoform X1
- UniProtKB: Q8VIM2 (UniProtKB/Swiss-Prot),   Q8VIM1 (UniProtKB/Swiss-Prot),   Q7TPU2 (UniProtKB/Swiss-Prot),   Q5QNS5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011247086   ⟸   XM_011248784
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_011247085   ⟸   XM_011248783
- Peptide Label: isoform X1
- UniProtKB: Q8VIM2 (UniProtKB/Swiss-Prot),   Q8VIM1 (UniProtKB/Swiss-Prot),   Q7TPU2 (UniProtKB/Swiss-Prot),   Q5QNS5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_030101483   ⟸   XM_030245623
- Peptide Label: isoform X2
- UniProtKB: Q8VIM2 (UniProtKB/Swiss-Prot),   Q8VIM1 (UniProtKB/Swiss-Prot),   Q7TPU2 (UniProtKB/Swiss-Prot),   Q5QNS5 (UniProtKB/Swiss-Prot),   A0A0A0MQ86 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSMUSP00000043827   ⟸   ENSMUST00000047568
RefSeq Acc Id: ENSMUSP00000080503   ⟸   ENSMUST00000081819
RefSeq Acc Id: ENSMUSP00000104846   ⟸   ENSMUST00000109223
RefSeq Acc Id: ENSMUSP00000104847   ⟸   ENSMUST00000109224
Protein Domains
Ig-like   Ig-like V-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5QNS5-F1-model_v2 AlphaFold Q5QNS5 1-305 view protein structure

Promoters
RGD ID:8674416
Promoter ID:EPDNEW_M15239
Type:multiple initiation site
Name:Havcr1_1
Description:Mus musculus hepatitis A virus cellular receptor 1 , transcriptvariant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381146,740,220 - 46,740,280EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2159680 AgrOrtholog
Ensembl Genes ENSMUSG00000040405 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000047568 ENTREZGENE
  ENSMUST00000047568.5 UniProtKB/TrEMBL
  ENSMUST00000081819 ENTREZGENE
  ENSMUST00000081819.11 UniProtKB/TrEMBL
  ENSMUST00000109223 ENTREZGENE
  ENSMUST00000109223.8 UniProtKB/TrEMBL
  ENSMUST00000109224.9 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ig-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_V-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:171283 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:2159680 ENTREZGENE
NCBI Gene 171283 ENTREZGENE
PANTHER HEPATITIS A VIRUS CELLULAR RECEPTOR 1 HOMOLOG UniProtKB/Swiss-Prot
  HEPATITIS A VIRUS CELLULAR RECEPTOR 1 HOMOLOG UniProtKB/Swiss-Prot
  HEPATITIS A VIRUS CELLULAR RECEPTOR 1 HOMOLOG UniProtKB/TrEMBL
  HEPATITIS A VIRUS CELLULAR RECEPTOR 1 HOMOLOG UniProtKB/TrEMBL
Pfam V-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB HAVCR1 RGD
PhenoGen Havcr1 PhenoGen
PROSITE IG_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SM00409 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0A0MQ86 ENTREZGENE, UniProtKB/TrEMBL
  E9QPA7_MOUSE UniProtKB/TrEMBL
  HAVR1_MOUSE UniProtKB/Swiss-Prot
  Q3V033 ENTREZGENE, UniProtKB/TrEMBL
  Q5QNS5 ENTREZGENE
  Q7TPU2 ENTREZGENE
  Q8VIM1 ENTREZGENE
  Q8VIM2 ENTREZGENE
UniProt Secondary Q7TPU2 UniProtKB/Swiss-Prot
  Q8VIM1 UniProtKB/Swiss-Prot
  Q8VIM2 UniProtKB/Swiss-Prot