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Gene: Enpp1 (ectonucleotide pyrophosphatase/phosphodiesterase 1) Mus musculus
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Symbol: Enpp1
Name: ectonucleotide pyrophosphatase/phosphodiesterase 1
Description: Exhibits several functions, including hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides; metal ion binding activity; and phosphodiesterase I activity. Involved in several processes, including negative regulation of bone mineralization; negative regulation of fat cell differentiation; and negative regulation of hh target transcription factor activity. Localizes to cell surface; extracellular space; and integral component of plasma membrane. Is expressed in several structures, including central nervous system; integumental system; limb; sensory organ; and tooth. Used to study arterial calcification of infancy; bone disease (multiple); and middle ear disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including arterial calcification of infancy; end stage renal disease; obesity; ossification of the posterior longitudinal ligament of spine; and type 2 diabetes mellitus. Orthologous to human ENPP1 (ectonucleotide pyrophosphatase/phosphodiesterase 1).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 1 ectonucleotide pyrophosphatase/phosphodiesterase 1; 4833416E15Rik; AI428932; C76301; CD203c; E-NPP 1; E-NPP1; ectonucleotide pyrophosphatase/phosphodiesterase family member 1; Ly-41; lymphocyte antigen 41; M6S1; NPP1; Npps; PC-1; Pca; Pca-1; Pdnp1; phosphodiesterase I/nucleotide pyrophosphatase 1; plasma-cell membrane glycoprotein PC-1; RIKEN cDNA 4833416E15 gene; tiptoe walking; ttw; twy
Orthologs:
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38.p6 Ensembl1024,637,914 - 24,712,159 (-)EnsemblGRCm38mm10GRCm38
GRCm381024,637,914 - 24,712,159 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371024,361,217 - 24,431,908 (-)NCBIGRCm37mm9NCBIm37
MGSCv361024,330,827 - 24,401,518 (-)NCBImm8
Celera1025,583,320 - 25,641,223 (-)NCBICelera
Cytogenetic Map10A4NCBI
cM Map1012.26NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
Nomenclature History
 
More on Enpp1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 733393
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-07-14
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.