Alox15 (arachidonate 15-lipoxygenase) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Alox15 (arachidonate 15-lipoxygenase) Mus musculus
Analyze
Symbol: Alox15
Name: arachidonate 15-lipoxygenase
RGD ID: 733626
MGI Page MGI
Description: Enables arachidonate 12(S)-lipoxygenase activity and arachidonate 15-lipoxygenase activity. Involved in several processes, including fatty acid metabolic process; phosphatidylethanolamine biosynthetic process; and positive regulation of actin filament polymerization. Acts upstream of or within bone mineralization. Located in cytosol and plasma membrane. Is expressed in several structures, including alimentary system; liver; nose; peritoneal fluid; and respiratory system. Orthologous to human ALOX15 (arachidonate 15-lipoxygenase).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 12-; 12-LO; 12-LOX; 12/15-lipoxygenase; 12/15-LO; 15-LOX; Alo; Alox12l; arachidonate 12-lipoxygenase, leukocyte-type; arachidonate omega-6 lipoxygenase; hepoxilin A3 synthase Alox15; L-1; L-12LO; linoleate 13S-lipoxygenase; polyunsaturated fatty acid lipoxygenase ALOX15
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391170,234,973 - 70,279,465 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1170,234,978 - 70,242,857 (-)EnsemblGRCm39 Ensembl
GRCm381170,344,147 - 70,390,538 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1170,344,152 - 70,352,031 (-)EnsemblGRCm38mm10GRCm38
MGSCv371170,157,649 - 70,165,533 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361170,160,348 - 70,168,210 (-)NCBIMGSCv36mm8
Celera1177,888,721 - 77,896,673 (-)NCBICelera
Cytogenetic Map11B3NCBI
cM Map1142.99NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(4Z,7Z,10Z,13Z,15E,19Z)-17-hydroxydocosahexaenoic acid  (EXP)
(5Z,8Z,11Z,13E)-15-HETE  (EXP,ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,7-dihydropurine-6-thione  (ISO)
4,4'-sulfonyldiphenol  (EXP)
6-oxoprostaglandin F1alpha  (EXP)
6-propyl-2-thiouracil  (ISO)
8-(4-chlorophenylthio)-cGMP  (ISO)
acetamide  (ISO)
acetylcholine  (EXP)
acrylamide  (ISO)
Actein  (ISO)
all-trans-retinoic acid  (ISO)
allethrin  (ISO)
alpha-Artemisic acid  (ISO)
arachidonic acid  (EXP,ISO)
aristolochic acid A  (ISO)
aspartame  (EXP)
baicalein  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
bifenthrin  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bromobenzene  (ISO)
C60 fullerene  (ISO)
carbon nanotube  (EXP)
cis-caffeic acid  (ISO)
Cuprizon  (ISO)
cyhalothrin  (ISO)
cypermethrin  (ISO)
Deoxycorticosterone acetate  (EXP)
diclofenac  (ISO)
dieldrin  (ISO)
dioxygen  (ISO)
diquat  (EXP)
disodium selenite  (EXP)
elemental selenium  (EXP,ISO)
EPTC  (ISO)
esculetin  (ISO)
ethanol  (ISO)
ethylparaben  (ISO)
fenvalerate  (ISO)
fulvestrant  (ISO)
hexachlorobenzene  (ISO)
Honokiol  (EXP,ISO)
hydralazine  (ISO)
indole-3-methanol  (ISO)
indometacin  (ISO)
lead diacetate  (ISO)
linoleic acid  (ISO)
lipopolysaccharide  (EXP)
losartan  (ISO)
lovastatin  (ISO)
masoprocol  (ISO)
mercaptopurine  (ISO)
metformin  (ISO)
methimazole  (ISO)
methotrexate  (ISO)
Monobutylphthalate  (EXP)
monosodium L-glutamate  (EXP)
nickel atom  (ISO)
nitroglycerin  (ISO)
NS-398  (ISO)
oxaliplatin  (ISO)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenformin  (ISO)
potassium dichromate  (EXP)
progesterone  (EXP,ISO)
prostaglandin E2  (EXP)
purine-6-thiol  (ISO)
pyrethrins  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
selenium atom  (EXP,ISO)
selenomethionine  (EXP)
silicon dioxide  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
starch  (ISO)
sulfadimethoxine  (ISO)
sulindac  (ISO)
sulindac sulfide  (ISO)
sulindac sulfone  (ISO)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
toluene  (ISO)
topotecan  (ISO)
trans-caffeic acid  (ISO)
trichloroethene  (EXP,ISO)
triclosan  (ISO)
trimellitic anhydride  (EXP)
triptonide  (EXP)
valproic acid  (ISO)
valsartan  (EXP)
vinclozolin  (ISO)
vorinostat  (ISO)
withaferin A  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Regulation of neuronal type genes in congestive heart failure rats. Andersson KB, etal., Acta Physiol (Oxf). 2006 Jan;186(1):17-27.
2. Interdependence of lipoxin A4 and heme-oxygenase in counter-regulating inflammation during corneal wound healing. Biteman B, etal., FASEB J. 2007 Jul;21(9):2257-66. Epub 2007 Mar 23.
3. Neuroprotection of early and short-time applying atorvastatin in the acute phase of cerebral ischemia: down-regulated 12/15-LOX, p38MAPK and cPLA2 expression, ameliorated BBB permeability. Cui L, etal., Brain Res. 2010 Apr 14;1325:164-73. Epub 2010 Feb 16.
4. 12/15-Lipoxygenase regulates the inflammatory response to bacterial products in vivo. Dioszeghy V, etal., J Immunol. 2008 Nov 1;181(9):6514-24.
5. Experimental allergic encephalomyelitis is exacerbated in mice deficient for 12/15-lipoxygenase or 5-lipoxygenase. Emerson MR and LeVine SM, Brain Res. 2004 Sep 17;1021(1):140-5.
6. A role for the mouse 12/15-lipoxygenase pathway in promoting epithelial wound healing and host defense. Gronert K, etal., J Biol Chem. 2005 Apr 15;280(15):15267-78. Epub 2005 Feb 11.
7. Arachidonate 12-lipoxygenase of rat pineal glands: catalytic properties and primary structure deduced from its cDNA. Hada T, etal., Biochim Biophys Acta 1994 Mar 3;1211(2):221-8.
8. 12/15-Lipoxygenase deficiency protects mice from allergic airways inflammation and increases secretory IgA levels. Hajek AR, etal., J Allergy Clin Immunol. 2008 Sep;122(3):633-9.e3. Epub 2008 Aug 9.
9. Protecting against cerebrovascular injury: contributions of 12/15-lipoxygenase to edema formation after transient focal ischemia. Jin G, etal., Stroke. 2008 Sep;39(9):2538-43. Epub 2008 Jul 17.
10. Co-regulated expression of glomerular 12/15-lipoxygenase and interleukin-4 mRNAs in rat nephrotoxic nephritis. Katoh T, etal., Kidney Int. 1994 Aug;46(2):341-9.
11. Cardiac 12/15 lipoxygenase-induced inflammation is involved in heart failure. Kayama Y, etal., J Exp Med. 2009 Jul 6;206(7):1565-74. Epub 2009 Jun 22.
12. 12/15-lipoxygenase counteracts inflammation and tissue damage in arthritis. Kronke G, etal., J Immunol. 2009 Sep 1;183(5):3383-9. Epub 2009 Aug 12.
13. Effects of vitamin E on mitochondrial dysfunction and asthma features in an experimental allergic murine model. Mabalirajan U, etal., J Appl Physiol. 2009 Oct;107(4):1285-92. Epub 2009 Jul 23.
14. Disruption of the 12/15-lipoxygenase gene (Alox15) protects hyperlipidemic mice from nonalcoholic fatty liver disease. Martinez-Clemente M, etal., Hepatology. 2010 Dec;52(6):1980-91. doi: 10.1002/hep.23928. Epub 2010 Oct 21.
15. Nonobese diabetic (NOD) mice congenic for a targeted deletion of 12/15-lipoxygenase are protected from autoimmune diabetes. McDuffie M, etal., Diabetes. 2008 Jan;57(1):199-208. Epub 2007 Oct 16.
16. MGDs mouse GO annotations MGD data from the GO Consortium
17. MGD IEA MGD IEA
18. Different roles of 12/15-lipoxygenase in diabetic large and small fiber peripheral and autonomic neuropathies. Obrosova IG, etal., Am J Pathol. 2010 Sep;177(3):1436-47. Epub 2010 Aug 19.
19. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
20. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
21. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
22. 12/15-lipoxygenase is increased in Alzheimer's disease: possible involvement in brain oxidative stress. Pratico D, etal., Am J Pathol. 2004 May;164(5):1655-62.
23. Mouse MP Annotation Import Pipeline RGD automated import pipeline
24. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
25. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
26. A microarray study of gene expression profiles in nasal polyps. Rostkowska-Nadolska B, etal., Auris Nasus Larynx. 2011 Feb;38(1):58-64. Epub 2010 Jun 15.
27. 12/15-lipoxygenase is required for the early onset of high fat diet-induced adipose tissue inflammation and insulin resistance in mice. Sears DD, etal., PLoS One. 2009 Sep 29;4(9):e7250.
28. Disruption of 12/15-lipoxygenase expression in peritoneal macrophages. Enhanced utilization of the 5-lipoxygenase pathway and diminished oxidation of low density lipoprotein. Sun D and Funk CD, J Biol Chem. 1996 Sep 27;271(39):24055-62.
29. Additive anti-atherogenic effect of thromboxane receptor antagonism with 12/15lipoxygenase gene disruption in apolipoprotein E-deficient mice. Tang L, etal., Atherosclerosis. 2008 Aug;199(2):265-70. Epub 2008 Jan 22.
30. Shengmai Yin formula exerts cardioprotective effects on rats with chronic heart failure via regulating Linoleic Acid metabolism. Wang S, etal., Prostaglandins Other Lipid Mediat. 2022 Feb;158:106608. doi: 10.1016/j.prostaglandins.2021.106608. Epub 2021 Dec 24.
31. Amelioration of the Alzheimer's disease phenotype by absence of 12/15-lipoxygenase. Yang H, etal., Biol Psychiatry. 2010 Nov 15;68(10):922-9. Epub 2010 Jun 8.
32. Improved survival and reduced vascular permeability by eliminating or blocking 12/15-lipoxygenase in mouse models of acute lung injury (ALI). Zarbock A, etal., J Immunol. 2009 Oct 1;183(7):4715-22. Epub 2009 Sep 14.
Additional References at PubMed
PMID:7492614   PMID:7576099   PMID:7811740   PMID:8188678   PMID:8944751   PMID:9518531   PMID:10330425   PMID:10349636   PMID:10359569   PMID:10432118   PMID:11042159   PMID:11076861  
PMID:11217851   PMID:11278875   PMID:11342477   PMID:11581143   PMID:12122008   PMID:12466851   PMID:12477932   PMID:12707289   PMID:12845410   PMID:14673007   PMID:14681479   PMID:14688261  
PMID:14716014   PMID:15451785   PMID:15489334   PMID:15576842   PMID:15681297   PMID:15743778   PMID:15781699   PMID:16037566   PMID:16141072   PMID:16141073   PMID:16251421   PMID:16254318  
PMID:16303615   PMID:16365418   PMID:16514433   PMID:16543492   PMID:16547277   PMID:16762578   PMID:16820097   PMID:16823721   PMID:17043146   PMID:17053180   PMID:17170102   PMID:17426145  
PMID:17873277   PMID:17943024   PMID:18165353   PMID:18296557   PMID:18311922   PMID:18346986   PMID:18511709   PMID:18762024   PMID:18780776   PMID:19095999   PMID:19130894   PMID:19260872  
PMID:19373248   PMID:19380786   PMID:19509298   PMID:19521344   PMID:19713213   PMID:19734227   PMID:19819949   PMID:19822654   PMID:20008149   PMID:20068575   PMID:20130191   PMID:20357242  
PMID:20449608   PMID:20647030   PMID:20689558   PMID:20947825   PMID:20953328   PMID:21040253   PMID:21220563   PMID:21228311   PMID:21267068   PMID:21474962   PMID:21540548   PMID:21677750  
PMID:21841162   PMID:21873635   PMID:22215650   PMID:22267335   PMID:22275352   PMID:22279185   PMID:22467300   PMID:22472308   PMID:22502743   PMID:22503541   PMID:22573549   PMID:22637477  
PMID:22730527   PMID:22832496   PMID:22973824   PMID:23070608   PMID:23079635   PMID:23233787   PMID:23326022   PMID:23437231   PMID:23437353   PMID:23477864   PMID:23528921   PMID:23589307  
PMID:23624557   PMID:23650615   PMID:23664097   PMID:23809162   PMID:23862663   PMID:24039864   PMID:24045154   PMID:24089193   PMID:24121057   PMID:24163073   PMID:24194600   PMID:24248985  
PMID:24291223   PMID:24300237   PMID:24891522   PMID:24990750   PMID:25071151   PMID:25100742   PMID:25105362   PMID:25187369   PMID:25251155   PMID:25313597   PMID:25402683   PMID:25498966  
PMID:25549319   PMID:25576922   PMID:25698732   PMID:25713055   PMID:25824823   PMID:25844901   PMID:25873311   PMID:26075897   PMID:26292977   PMID:26432261   PMID:26438362   PMID:26492974  
PMID:26686860   PMID:26956187   PMID:27362803   PMID:27499089   PMID:27507404   PMID:27634046   PMID:27698118   PMID:27838820   PMID:28229935   PMID:28339608   PMID:28351645   PMID:28411230  
PMID:28436420   PMID:28566277   PMID:28694081   PMID:28724635   PMID:28827690   PMID:28842399   PMID:28923202   PMID:29167447   PMID:29184033   PMID:29235036   PMID:29468369   PMID:29526491  
PMID:29539416   PMID:29605541   PMID:29702245   PMID:29891910   PMID:29913136   PMID:29913556   PMID:30110365   PMID:30550785   PMID:30602353   PMID:30792307   PMID:30944221   PMID:31349026  
PMID:31353262   PMID:31923770   PMID:32234475   PMID:32259664   PMID:32721046   PMID:32760397   PMID:32768245   PMID:32814052   PMID:32913122   PMID:32918502   PMID:33335297   PMID:33456570  
PMID:33595729   PMID:34093589   PMID:34128835   PMID:34313733   PMID:34474105   PMID:34706241   PMID:34866403   PMID:34979449   PMID:35041620   PMID:35090880   PMID:35622894   PMID:35767947  
PMID:36077303   PMID:36206855   PMID:36599368   PMID:36987924   PMID:37143678   PMID:37253655   PMID:37468019   PMID:38030974  


Genomics

Comparative Map Data
Alox15
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391170,234,973 - 70,279,465 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1170,234,978 - 70,242,857 (-)EnsemblGRCm39 Ensembl
GRCm381170,344,147 - 70,390,538 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1170,344,152 - 70,352,031 (-)EnsemblGRCm38mm10GRCm38
MGSCv371170,157,649 - 70,165,533 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361170,160,348 - 70,168,210 (-)NCBIMGSCv36mm8
Celera1177,888,721 - 77,896,673 (-)NCBICelera
Cytogenetic Map11B3NCBI
cM Map1142.99NCBI
ALOX15
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38174,630,919 - 4,641,678 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl174,630,919 - 4,642,294 (-)EnsemblGRCh38hg38GRCh38
GRCh37174,534,214 - 4,544,973 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36174,480,963 - 4,491,709 (-)NCBINCBI36Build 36hg18NCBI36
Build 34174,480,964 - 4,491,709NCBI
Celera174,546,922 - 4,554,338 (-)NCBICelera
Cytogenetic Map17p13.2NCBI
HuRef174,423,571 - 4,434,147 (-)NCBIHuRef
CHM1_1174,542,997 - 4,553,746 (-)NCBICHM1_1
T2T-CHM13v2.0174,520,655 - 4,531,416 (-)NCBIT2T-CHM13v2.0
Alox15
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81055,559,060 - 55,567,535 (-)NCBIGRCr8
mRatBN7.21055,060,169 - 55,068,885 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1055,060,412 - 55,068,874 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1059,739,979 - 59,748,431 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01059,228,481 - 59,236,931 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01054,727,685 - 54,736,135 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01056,953,692 - 56,962,145 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1056,953,691 - 56,962,161 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01056,704,488 - 56,713,186 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41057,185,939 - 57,194,388 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11057,199,562 - 57,208,011 (-)NCBI
Celera1054,211,640 - 54,220,083 (-)NCBICelera
Cytogenetic Map10q24NCBI
Alox15
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495546710,032,792 - 10,039,789 (-)NCBIChiLan1.0ChiLan1.0
ALOX15
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21912,246,447 - 12,258,698 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11714,214,750 - 14,226,986 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0174,686,339 - 4,696,877 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1174,677,125 - 4,687,669 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl174,677,125 - 4,687,669 (-)Ensemblpanpan1.1panPan2
ALOX15
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1531,883,544 - 31,891,357 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl531,882,501 - 32,038,119 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha532,022,707 - 32,030,999 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0531,988,523 - 31,996,819 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl531,988,497 - 31,996,890 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1531,954,788 - 31,963,077 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0531,914,466 - 31,922,749 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0532,090,734 - 32,099,028 (+)NCBIUU_Cfam_GSD_1.0
Alox15
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560252,659,633 - 52,689,018 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366773,232,183 - 3,241,253 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366773,232,183 - 3,241,307 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ALOX15
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1164,112,795 - 4,121,764 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl164,111,151 - 4,121,645 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605917,518,868 - 17,530,240 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Alox15
1042 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:302
Count of miRNA genes:249
Interacting mature miRNAs:261
Transcripts:ENSMUST00000019068, ENSMUST00000130000
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884453Sklq16_mskull length QTL 16, 16 week (mouse)11325000072690826Mouse
13208559Wght10_mweight 10 (mouse)11395000088890826Mouse
13208558Lgth12_mbody length 12 (mouse)11395000094890826Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11688027789019734Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1912420496897826Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112180736495881231Mouse
13208569Bmiq10_mbody mass index QTL 10 (mouse)113589082784890826Mouse
1301328Mol4_mmodifier of LPS-response 4 (mouse)Not determined113628257783481356Mouse
1301788Lbw8_mlupus NZB x NZW 8 (mouse)Not determined113650328770509492Mouse
1301896Tria1_mT-cell receptor induced activation 1 (mouse)Not determined113661356570613855Mouse
4141853Skmw17_mskeletal muscle weight 17 (mouse)Not determined113708094171081064Mouse
10766457Nwa3_mNew Zealand White autoimmunity 3 (mouse)113801611572016209Mouse
11532698Sluc36a_msusceptibility to lung cancer 36a (mouse)114225661776256730Mouse
11532699Sluc36b_msusceptibility to lung cancer 36b (mouse)114225661776256730Mouse
4142300Ctrq3_mC. trachomatis resistance QTL 3 (mouse)Not determined114463003876854757Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44630038113058009Mouse
1302021Nidd1n_mnon-insulin-dependent diabetes mellitus 1 in NSY (mouse)Not determined114516587379978324Mouse
1357878Mastr_mmodifier of astrocytoma (mouse)Not determined114570858189818733Mouse
1300765Bbaa4_mB.burgdorferi-associated arthritis 4 (mouse)Not determined114618516780185262Mouse
1301988Bmd11_mbone mineral density 11 (mouse)Not determined114631940780319522Mouse
1301830Ssta4_msusceptibility to Salmonella typhimurium antigens 4 (mouse)Not determined115007819184078411Mouse
13524840Ppiq9a_mprepulse inhibition QTL 9a (mouse)115249438586494385Mouse
1300774Pgia7_mproteoglycan induced arthritis 7 (mouse)Not determined115339058887390737Mouse
4141830Pregq1_mpregnancy QTL 1 (mouse)Not determined115412675283733652Mouse
4141875Etax9_methanol induced ataxia 9 (mouse)Not determined5528498572209927Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156864027114157957Mouse
1300664Etohcta9_methanol conditioned taste aversion 9 (mouse)Not determined115775466091754758Mouse
10053682Eae45_mexperimental allergic encephalomyelitis susceptibility 45 (mouse)Not determined115849055574754758Mouse
1300924Ity2_mimmunity to S. typhimurium 2 (mouse)Not determined15850803087695238Mouse
4141982Skts-fp2_mskin tumor susceptibility in FVB and PWK 2 (mouse)Not determined5871926685066529Mouse
1301987Pid3_mprior incubation determinant 3 (mouse)Not determined116168682088699728Mouse
1301319Dautb4_mdopamine uptake transporter binding 4 (mouse)Not determined116215600596156153Mouse
27226730Tibmd1_mtibia midshaft diameter 1, 5 week (mouse)1162590826109390826Mouse
1301999Lmr15_mleishmaniasis resistance 15 (mouse)Not determined116331940781830473Mouse
10044004Stzid3_mstreptozotocin induced diabetes susceptibility 3 (mouse)Not determined116331940794063918Mouse
11039502Ltpr6b_mLeishmania tropica response 6b (mouse)116483033698830473Mouse
11039501Ltpr6a_mLeishmania tropica response 6a (mouse)116483033698830473Mouse
11039515Ltpr6_mLeishmania tropica response 6 (mouse)116483033698830473Mouse
1357766Si5lq6_mserum IGFBP-5 level QTL 6 (mouse)Not determined1166733420100733652Mouse
1301546Pcir2_mperiosteal circumference 2 (mouse)Not determined1166733420100733652Mouse
1301833Tbbmd5_mtotal body bone mineral density 5 (mouse)Not determined1166733420100733652Mouse
1300628Lgth6_mbody length 6 (mouse)Not determined1166733420100733652Mouse
4141012Femwf6_mfemur work to failure 6 (mouse)Not determined66733420100733652Mouse
1300784Prdt3_mprion disease incubation time 3 (mouse)Not determined1166733420100733652Mouse
4142316Ity2b_mimmunity to S. typhimurium 2b (mouse)Not determined116707819179813912Mouse
27226783Tibl5_mtibia length 5, 5 week (mouse)1168190826101890826Mouse
36049778Ars6_mantibody response to SARS-CoV 6, day 15, IgM (mouse)116899082672490826Mouse
36049779Ars7_mantibody response to SARS-CoV 7, day 29, IgG1 (mouse)116899082672490826Mouse
36049784Ars8_mantibody response to SARS-CoV 8, day 29, IgG2a+IgG2c (mouse)116899082672490826Mouse
36049785Ars9_mantibody response to SARS-CoV 9, day 29, IgM (mouse)116899082672490826Mouse
36049786Ars10_mantibody response to SARS-CoV 10, 4 days post-rechallenge, IgG2a+IgG2c (mouse)116899082672490826Mouse
36049787Ars11_mantibody response to SARS-CoV 11, 4 days post-rechallenge, IgM (mouse)116899082672490826Mouse
36049788Ars1_mantibody response to SARS-CoV 1, day 7, IgG1 (mouse)116899082672490826Mouse
36049789Ars2_mantibody response to SARS-CoV 2, day 7, IgG2a+IgG2c (mouse)116899082672490826Mouse
36049790Ars3_mantibody response to SARS-CoV 3, day 7, IgG2b (mouse)116899082672490826Mouse
36049791Ars4_mantibody response to SARS-CoV 4, day 7, IgG3 (mouse)116899082672490826Mouse
36049792Ars5_mantibody response to SARS-CoV 5, day 7, IgM (mouse)116899082672490826Mouse
35673314Ari2_mantibody response to influenza 2, day 10, IgG3 (mouse)116899082672490826Mouse


Expression


Sequence


RefSeq Acc Id: ENSMUST00000019068   ⟹   ENSMUSP00000019068
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1170,234,978 - 70,242,857 (-)Ensembl
GRCm38.p6 Ensembl1170,344,152 - 70,352,031 (-)Ensembl
RefSeq Acc Id: ENSMUST00000130000
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1170,235,431 - 70,236,522 (-)Ensembl
GRCm38.p6 Ensembl1170,344,605 - 70,345,696 (-)Ensembl
RefSeq Acc Id: NM_009660   ⟹   NP_033790
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391170,234,973 - 70,242,857 (-)NCBI
GRCm381170,344,147 - 70,352,031 (-)NCBI
MGSCv371170,157,649 - 70,165,533 (-)RGD
Celera1177,888,721 - 77,896,673 (-)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006532036   ⟹   XP_006532099
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391170,234,973 - 70,279,465 (-)NCBI
GRCm381170,344,147 - 70,390,538 (-)NCBI
Sequence:
RefSeq Acc Id: NP_033790   ⟸   NM_009660
- UniProtKB: Q5F2E3 (UniProtKB/Swiss-Prot),   Q4FJY9 (UniProtKB/Swiss-Prot),   Q6PHB2 (UniProtKB/Swiss-Prot),   P39654 (UniProtKB/Swiss-Prot),   A2CF88 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006532099   ⟸   XM_006532036
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000019068   ⟸   ENSMUST00000019068
Protein Domains
Lipoxygenase   PLAT

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P39654-F1-model_v2 AlphaFold P39654 1-663 view protein structure

Promoters
RGD ID:8675310
Promoter ID:EPDNEW_M15686
Type:single initiation site
Name:Alox15_1
Description:Mus musculus arachidonate 15-lipoxygenase , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381170,352,031 - 70,352,091EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:87997 AgrOrtholog
Ensembl Genes ENSMUSG00000018924 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000019068 ENTREZGENE
  ENSMUST00000019068.7 UniProtKB/Swiss-Prot
Gene3D-CATH 3.10.450.60 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLAT/LH2 domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro LipOase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LipOase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LipOase_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LipOase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LipOase_Fe_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LipOase_mml UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLAT/LH2_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLAT/LH2_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLAT_LOX_verte UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:11687 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:87997 ENTREZGENE
NCBI Gene 11687 ENTREZGENE
PANTHER POLYUNSATURATED FATTY ACID LIPOXYGENASE ALOX15 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11771 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Lipoxygenase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Alox15 PhenoGen
PRINTS LIPOXYGENASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAMLPOXGNASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE LIPOXYGENASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LIPOXYGENASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LIPOXYGENASE_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART LH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48484 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49723 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A2CF88 ENTREZGENE, UniProtKB/TrEMBL
  LOX15_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q4FJY9 ENTREZGENE
  Q5F2E3 ENTREZGENE
  Q6PHB2 ENTREZGENE
UniProt Secondary Q4FJY9 UniProtKB/Swiss-Prot
  Q5F2E3 UniProtKB/Swiss-Prot
  Q6PHB2 UniProtKB/Swiss-Prot