CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: acenocoumarol
Accession: CHEBI:53766
browse the term
Definition: A hydroxycoumarin that is warfarin in which the hydrogen at position 4 of the phenyl substituent is replaced by a nitro group.
Synonyms: related_synonym: 3-(alpha-(4'-Nitrophenyl)-beta-acetylethyl)-4-hydroxycoumarin; 3-(alpha-(p-Nitrophenol)-beta-acetylethyl)-4-hydroxycoumarin; 3-(alpha-Acetonyl-4-nitrobenzyl)-4-hydroxycoumarin; 3-(alpha-Acetonyl-p-nitrobenzyl)-4-hydroxycoumarin; 3-(alpha-p-Nitrophenyl-beta-acetylethyl)-4-hydroxycoumarin; 4-Hydroxy-3-(1-(4-nitrophenyl)-3-oxobutyl)-2H-1-benzopyran-2-one; 4-Hydroxy-3-[1-(4-nitrophenyl)-3-oxobutyl]-2H-chromen-2-one; Acenocoumarin; Acenocumarolo; Acenokumarin; Formula=C19H15NO6; InChI=1S/C19H15NO6/c1-11(21)10-15(12-6-8-13(9-7-12)20(24)25)17-18(22)14-4-2-3-5-16(14)26-19(17)23/h2-9,15,22H,10H2,1H3; InChIKey=VABCILAOYCMVPS-UHFFFAOYSA-N; Nicoumalone; Nicumalon; Nitrophenylacetylethyl-4-hydroxycoumarine; Nitrovarfarian; Nitrowarfarin; SMILES=CC(=O)CC(c1ccc(cc1)[N+]([O-])=O)c1c(O)c2ccccc2oc1=O; acenocoumarolum; acenocumarol
alt_id: CHEBI:494206
xref: CAS:152-72-7; DrugBank:DB01418; KEGG:D07064; LINCS:LSM-5112
xref_mesh: MESH:D000074
xref: PMID:17275317; Patent:US2648682; Reaxys:1269370
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Abcb1a
ATP binding cassette subfamily B member 1A
affects response to substance
ISO
ABCB1 gene polymorphism affects the susceptibility to Acenocoumarol
CTD
PMID:18021343
NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135
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Apoe
apolipoprotein E
affects response to substance
ISO
APOE gene polymorphism affects the susceptibility to Acenocoumarol
CTD
PMID:15861030
NCBI chr 1:88,481,889...88,485,816
Ensembl chr 1:88,481,385...88,485,855
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
affects metabolic processing
ISO
CYP1A1 protein affects the metabolism of Acenocoumarol
CTD
PMID:11918509
NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012
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Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
affects metabolic processing
ISO
CYP1A2 protein affects the metabolism of Acenocoumarol
CTD
PMID:11918509
NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149
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Cyp2c11
cytochrome P450, subfamily 2, polypeptide 11
affects response to substance
ISO
CYP2C18 gene polymorphism affects the susceptibility to Acenocoumarol
CTD
PMID:19578179
NCBI chr 1:246,175,216...246,211,445
Ensembl chr 1:246,174,711...246,211,853
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Cyp2c6
cytochrome P450, family 2, subfamily C, polypeptide 6
affects metabolic processing
ISO
CYP2C19 protein affects the metabolism of Acenocoumarol
CTD
PMID:11918509
NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:247,879,078...247,916,798
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F10
coagulation factor X
decreases activity
EXP
Acenocoumarol results in decreased activity of F10 protein
CTD
PMID:3490277
NCBI chr16:83,170,973...83,190,280
Ensembl chr16:83,170,977...83,190,280
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F2
coagulation factor II, thrombin
decreases activity
EXP
Acenocoumarol results in decreased activity of F2 protein
CTD
PMID:3490277
NCBI chr 3:98,051,958...98,065,246
Ensembl chr 3:98,051,960...98,065,246
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F5
coagulation factor V
decreases activity
EXP
Acenocoumarol results in decreased activity of F5 protein
CTD
PMID:3490277
NCBI chr13:79,046,657...79,116,247
Ensembl chr13:79,046,448...79,116,247
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F7
coagulation factor VII
decreases activity
EXP
Acenocoumarol results in decreased activity of F7 protein
CTD
PMID:3490277
NCBI chr16:83,191,896...83,202,775
Ensembl chr16:83,191,914...83,202,738
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F9
coagulation factor IX
decreases activity
EXP
Acenocoumarol results in decreased activity of F9 protein
CTD
PMID:3490277
NCBI chr X:143,388,642...143,433,143
Ensembl chr X:143,388,621...143,433,146
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Ggcx
gamma-glutamyl carboxylase
increases activity
EXP
Acenocoumarol results in increased activity of GGCX protein
CTD
PMID:3490277
NCBI chr 4:106,027,918...106,043,653
Ensembl chr 4:106,027,912...106,043,923
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Vkorc1
vitamin K epoxide reductase complex, subunit 1
decreases response to substance increases response to substance affects response to substance multiple interactions decreases activity
ISO
VKORC1 promoter polymorphism results in decreased susceptibility to Acenocoumarol; VKORC1 protein polymorphism results in decreased susceptibility to Acenocoumarol VKORC1 protein results in increased susceptibility to Acenocoumarol VKORC1 gene polymorphism affects the susceptibility to Acenocoumarol; VKORC1 gene SNP affects the susceptibility to Acenocoumarol; VKORC1 intron SNP affects the susceptibility to Acenocoumarol; VKORC1 polymorphism affects the susceptibility to Acenocoumarol; VKORC1 protein polymorphism affects the susceptibility to Acenocoumarol Acenocoumarol inhibits the reaction [VKORC1 protein results in increased reduction of Vitamin K 1] Acenocoumarol results in decreased activity of VKORC1 protein
CTD
PMID:16201835 PMID:16611310 PMID:16869821 PMID:17036862 PMID:18698879 PMID:19578179 PMID:19875892 PMID:25042728 PMID:25866574 PMID:26757860 PMID:28867752 PMID:29581108 More...
NCBI chr 1:191,932,969...191,935,490
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Vkorc1l1
vitamin K epoxide reductase complex, subunit 1-like 1
multiple interactions decreases activity
ISO
Acenocoumarol inhibits the reaction [VKORC1L1 protein results in increased reduction of Vitamin K 1] Acenocoumarol results in decreased activity of VKORC1L1 protein
CTD
PMID:29581108
NCBI chr12:32,354,078...32,404,327
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