Axl (AXL receptor tyrosine kinase) - Rat Genome Database

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Gene: Axl (AXL receptor tyrosine kinase) Mus musculus
Analyze
Symbol: Axl
Name: AXL receptor tyrosine kinase
RGD ID: 1323765
MGI Page MGI
Description: Predicted to have several functions, including phosphatidylinositol 3-kinase binding activity; phosphatidylserine binding activity; and virus receptor activity. Involved in several processes, including animal organ development; myeloid cell homeostasis; and negative regulation of tumor necrosis factor production. Predicted to localize to several cellular components, including actin cytoskeleton; cell surface; and extracellular space. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and visual system. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human AXL (AXL receptor tyrosine kinase); PARTICIPATES IN Gas6 - Axl signaling axis; INTERACTS WITH 1,1-dichloroethene; 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: A; adhesion-related kinase; AI323647; Ark; Tyr; Tyro7; tyrosine-protein kinase receptor UFO; Uf; Ufo; ufo oncogene homolog
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Gm18404  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39725,455,925 - 25,488,502 (-)NCBIGRCm39mm39
GRCm39 Ensembl725,456,698 - 25,488,130 (-)Ensembl
GRCm38725,756,500 - 25,788,924 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl725,757,273 - 25,788,705 (-)EnsemblGRCm38mm10GRCm38
MGSCv37726,542,292 - 26,573,560 (-)NCBIGRCm37mm9NCBIm37
MGSCv36725,466,033 - 25,497,301 (-)NCBImm8
Celera720,366,185 - 20,397,512 (-)NCBICelera
Cytogenetic Map7A3NCBI
cM Map714.02NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (EXP)
1,2-dimethylhydrazine  (EXP)
1-naphthyl isothiocyanate  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-butoxyethanol  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-dichloroaniline  (ISO)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (EXP)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (EXP)
5-aza-2'-deoxycytidine  (ISO)
7,12-dimethyltetraphene  (ISO)
acetamide  (ISO)
acrylamide  (EXP)
actinomycin D  (ISO)
adefovir pivoxil  (ISO)
ADP  (ISO)
aflatoxin B1  (ISO)
aflatoxin B2  (ISO)
all-trans-retinoic acid  (EXP)
ammonium chloride  (ISO)
aristolochic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (ISO)
bisphenol F  (EXP)
buspirone  (ISO)
cadmium dichloride  (ISO)
cannabidiol  (EXP)
capecitabine  (ISO)
carbamazepine  (ISO)
carbon nanotube  (EXP)
chlordecone  (EXP)
chloroacetaldehyde  (ISO)
cidofovir anhydrous  (ISO)
cisplatin  (EXP,ISO)
clodronic acid  (ISO)
clofibrate  (EXP)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
CU-O LINKAGE  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cytarabine  (ISO)
dibutyl phthalate  (ISO)
dioxygen  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxifluridine  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
erlotinib hydrochloride  (ISO)
ethanol  (EXP)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
fenamidone  (EXP)
flutamide  (ISO)
folic acid  (EXP)
furan  (ISO)
gemcitabine  (ISO)
hydrogen peroxide  (EXP,ISO)
ifosfamide  (ISO)
Lasiocarpine  (ISO)
leflunomide  (ISO)
menaquinone  (ISO)
methapyrilene  (ISO)
methyl methanesulfonate  (ISO)
methylparaben  (ISO)
mithramycin  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (ISO)
nimesulide  (ISO)
nitric oxide  (EXP)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
phenethyl caffeate  (ISO)
phylloquinone  (ISO)
pirinixic acid  (EXP)
quercetin  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
SB 431542  (ISO)
selenium atom  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
silver atom  (EXP)
silver(0)  (EXP)
simvastatin  (ISO)
sodium arsenate  (EXP,ISO)
sodium arsenite  (ISO)
streptozocin  (ISO)
sunitinib  (ISO)
tetrachloromethane  (EXP,ISO)
toluene 2,4-diisocyanate  (EXP)
Tributyltin oxide  (EXP)
triphenyl phosphate  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (EXP)
urethane  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (EXP)
vincaleukoblastine  (ISO)
vinclozolin  (ISO)
vitamin E  (ISO)
vitamin K  (ISO)
warfarin  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ regeneration  (ISO)
apoptotic cell clearance  (IGI,IMP)
blood vessel remodeling  (IMP)
cell differentiation  (ISO)
cell maturation  (ISO)
cell migration  (IBA)
cellular response to extracellular stimulus  (IDA)
cellular response to hydrogen peroxide  (ISO)
cellular response to interferon-alpha  (ISO)
cellular response to lipopolysaccharide  (ISO)
dendritic cell differentiation  (ISO)
enzyme linked receptor protein signaling pathway  (IGI)
erythrocyte homeostasis  (IGI,IMP)
forebrain cell migration  (IGI)
immune system process  (IEA)
inflammatory response  (IMP)
innate immune response  (IEA)
natural killer cell differentiation  (IBA,IGI)
negative regulation of apoptotic process  (IBA,IGI,IMP,ISO)
negative regulation of cytokine production  (IGI)
negative regulation of dendritic cell apoptotic process  (ISO)
negative regulation of interferon-gamma production  (ISO)
negative regulation of lymphocyte activation  (IGI)
negative regulation of neuron apoptotic process  (IGI,IMP)
negative regulation of tumor necrosis factor production  (IGI)
nervous system development  (IBA)
neuron migration  (IGI,IMP)
neutrophil clearance  (IGI)
ovulation cycle  (IGI)
phagocytosis  (IBA,IGI,ISO)
phosphorylation  (IEA)
platelet activation  (IBA,IMP)
positive regulation of cytokine-mediated signaling pathway  (ISO)
positive regulation of kinase activity  (IBA)
positive regulation of natural killer cell differentiation  (ISO)
positive regulation of pinocytosis  (ISO)
positive regulation of protein kinase B signaling  (IBA,IMP)
positive regulation of viral life cycle  (ISO)
protein kinase B signaling  (IGI,IMP)
protein phosphorylation  (IEA)
secretion by cell  (IMP)
spermatogenesis  (IGI)
substrate adhesion-dependent cell spreading  (IMP)
transmembrane receptor protein tyrosine kinase signaling pathway  (IBA)
vagina development  (IGI)
viral entry into host cell  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal B cell activation  (IAGP)
abnormal blood vessel morphology  (IAGP)
abnormal brain thrombosis  (IAGP)
abnormal cerebellum morphology  (IAGP)
abnormal cerebral cortex morphology  (IAGP)
abnormal forebrain development  (IAGP)
abnormal forebrain morphology  (IAGP)
abnormal hippocampus morphology  (IAGP)
abnormal macrophage physiology  (IAGP)
abnormal neuronal migration  (IAGP)
abnormal professional antigen presenting cell physiology  (IAGP)
abnormal prostate gland epithelium morphology  (IAGP)
abnormal seminiferous tubule morphology  (IAGP)
abnormal spermatogenesis  (IAGP)
abnormal susceptibility to autoimmune disorder  (IAGP)
abnormal T cell activation  (IAGP)
abnormal thrombosis  (IAGP)
abnormal uterus morphology  (IAGP)
azoospermia  (IAGP)
blindness  (IAGP)
decreased Sertoli cell phagocytosis  (IAGP)
delayed estrous cycle  (IAGP)
delayed sexual maturation  (IAGP)
enlarged lymph nodes  (IAGP)
enlarged spleen  (IAGP)
enlarged uterus  (IAGP)
increased anti-double stranded DNA antibody level  (IAGP)
increased apoptosis  (IAGP)
increased autoantibody level  (IAGP)
increased B cell proliferation  (IAGP)
increased brain apoptosis  (IAGP)
increased circulating tumor necrosis factor level  (IAGP)
increased granulosa cell apoptosis  (IAGP)
increased lymphocyte cell number  (IAGP)
increased neuron apoptosis  (IAGP)
increased splenocyte apoptosis  (IAGP)
increased T cell proliferation  (IAGP)
increased vascular permeability  (IAGP)
internal hemorrhage  (IAGP)
joint inflammation  (IAGP)
liver degeneration  (IAGP)
male infertility  (IAGP)
no abnormal phenotype detected  (IEA)
prolonged estrous cycle  (IAGP)
prolonged proestrus  (IAGP)
reduced female fertility  (IAGP)
retinal cone cell degeneration  (IAGP)
retinal rod cell degeneration  (IAGP)
short diestrus  (IAGP)
skin lesions  (IAGP)
small endometrial glands  (IAGP)
small testis  (IAGP)
vagina atresia  (IAGP)
References

Additional References at PubMed
PMID:1320243   PMID:1834974   PMID:1840679   PMID:7542761   PMID:7784083   PMID:8108111   PMID:8524290   PMID:8610109   PMID:8943574   PMID:9395235   PMID:10227296   PMID:10322635  
PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11114734   PMID:11217851   PMID:12036992   PMID:12477932   PMID:15123721   PMID:15184064   PMID:15650770   PMID:15733062  
PMID:15782199   PMID:16141072   PMID:16141073   PMID:16365397   PMID:16585512   PMID:16602821   PMID:16627783   PMID:16723520   PMID:16751775   PMID:16831897   PMID:17151600   PMID:17332061  
PMID:17442946   PMID:17488688   PMID:17923589   PMID:18083102   PMID:18159085   PMID:18188450   PMID:18247125   PMID:18287559   PMID:18346204   PMID:18393392   PMID:18787040   PMID:18804096  
PMID:19211638   PMID:19463168   PMID:19602523   PMID:19625016   PMID:19729839   PMID:20080645   PMID:20348395   PMID:20363878   PMID:20483720   PMID:20546121   PMID:20603615   PMID:20635370  
PMID:21084607   PMID:21192804   PMID:21267068   PMID:21324877   PMID:21362131   PMID:21467176   PMID:21539887   PMID:21540291   PMID:21569627   PMID:21805534   PMID:21873635   PMID:21918185  
PMID:22043818   PMID:22327215   PMID:22538191   PMID:22740630   PMID:23071254   PMID:23082053   PMID:23259948   PMID:23325690   PMID:23754286   PMID:23774230   PMID:23799121   PMID:23840307  
PMID:23850380   PMID:23878224   PMID:24244024   PMID:24476074   PMID:24509082   PMID:24659691   PMID:24952961   PMID:24978606   PMID:25019319   PMID:25194421   PMID:25265470   PMID:25403570  
PMID:25502142   PMID:25514676   PMID:25603826   PMID:25766527   PMID:25826454   PMID:25904803   PMID:26206560   PMID:26276821   PMID:26523970   PMID:26792178   PMID:27034374   PMID:27038591  
PMID:27049947   PMID:27206970   PMID:27237127   PMID:27350258   PMID:27365404   PMID:27527599   PMID:27549806   PMID:27612415   PMID:27780404   PMID:27958361   PMID:28008921   PMID:28111081  
PMID:28352123   PMID:28423319   PMID:28786784   PMID:28916522   PMID:28925029   PMID:28935638   PMID:29030012   PMID:29251628   PMID:29719259   PMID:29895432   PMID:30033030   PMID:30038282  
PMID:30335822   PMID:30355768   PMID:30504829   PMID:30508140   PMID:30541554   PMID:30550785   PMID:30723115   PMID:30735494   PMID:30884311   PMID:31221818   PMID:31230815   PMID:31289116  
PMID:31550172   PMID:31762322   PMID:31896673   PMID:32325033   PMID:32364537   PMID:32611752   PMID:33529176  


Genomics

Comparative Map Data
Axl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39725,455,925 - 25,488,502 (-)NCBIGRCm39mm39
GRCm39 Ensembl725,456,698 - 25,488,130 (-)Ensembl
GRCm38725,756,500 - 25,788,924 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl725,757,273 - 25,788,705 (-)EnsemblGRCm38mm10GRCm38
MGSCv37726,542,292 - 26,573,560 (-)NCBIGRCm37mm9NCBIm37
MGSCv36725,466,033 - 25,497,301 (-)NCBImm8
Celera720,366,185 - 20,397,512 (-)NCBICelera
Cytogenetic Map7A3NCBI
cM Map714.02NCBI
AXL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1941,219,223 - 41,261,766 (+)EnsemblGRCh38hg38GRCh38
GRCh381941,219,223 - 41,261,766 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371941,725,128 - 41,767,671 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361946,416,948 - 46,459,511 (+)NCBINCBI36hg18NCBI36
Build 341946,416,662 - 46,459,510NCBI
Celera1938,525,268 - 38,567,818 (+)NCBI
Cytogenetic Map19q13.2NCBI
HuRef1938,157,135 - 38,200,127 (+)NCBIHuRef
CHM1_11941,724,837 - 41,767,370 (+)NCBICHM1_1
Axl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2181,265,656 - 81,296,278 (-)NCBI
Rnor_6.0 Ensembl182,549,420 - 82,580,761 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0182,550,892 - 82,580,761 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0183,812,118 - 83,840,542 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4180,964,751 - 80,994,300 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1181,045,570 - 81,045,733 (-)NCBI
Celera175,705,827 - 75,734,332 (-)NCBICelera
Cytogenetic Map1q21NCBI
Axl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955555189,174 - 218,565 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955555189,445 - 218,509 (+)NCBIChiLan1.0ChiLan1.0
AXL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11946,719,615 - 46,761,747 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1946,719,615 - 46,761,747 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01938,211,555 - 38,254,464 (+)NCBIMhudiblu_PPA_v0panPan3
AXL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11112,699,679 - 112,727,434 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1112,700,365 - 112,726,960 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1112,104,006 - 112,130,669 (-)NCBI
ROS_Cfam_1.01113,298,102 - 113,324,981 (-)NCBI
UMICH_Zoey_3.11112,859,212 - 112,885,893 (-)NCBI
UNSW_CanFamBas_1.01112,491,561 - 112,518,264 (-)NCBI
UU_Cfam_GSD_1.01113,484,923 - 113,511,641 (-)NCBI
Axl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934915,229,833 - 15,259,221 (+)NCBI
SpeTri2.0NW_0049366613,658,140 - 3,687,290 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AXL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl649,245,673 - 49,277,914 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1649,245,802 - 49,277,917 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2644,979,820 - 45,009,909 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.2645,072,278 - 45,073,025 (+)NCBISscrofa10.2Sscrofa10.2susScr3
AXL
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1635,537,718 - 35,580,143 (+)NCBI
ChlSab1.1 Ensembl635,537,773 - 35,580,716 (+)Ensembl
Vero_WHO_p1.0NW_02366607313,772,922 - 13,815,487 (+)NCBI
Axl
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462490776,236 - 106,765 (+)NCBI

Position Markers
AI323647  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38725,757,335 - 25,757,484UniSTSGRCm38
MGSCv37726,542,354 - 26,542,503UniSTSGRCm37
Celera720,366,247 - 20,366,396UniSTS
Cytogenetic Map7A3-B1UniSTS
Cytogenetic Map7A3UniSTS
Whitehead/MRC_RH7351.5UniSTS
Axl  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv37726,545,873 - 26,546,489UniSTSGRCm37
Celera720,369,766 - 20,370,382UniSTS
Cytogenetic Map7A3-B1UniSTS
cM Map76.0UniSTS
X63535  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38725,758,252 - 25,758,367UniSTSGRCm38
MGSCv37726,543,271 - 26,543,386UniSTSGRCm37
Celera720,367,164 - 20,367,279UniSTS
Cytogenetic Map7A3-B1UniSTS
Cytogenetic Map7A3UniSTS
Whitehead/MRC_RH7352.02UniSTS
Axl  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7A3-B1UniSTS
Axl  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38725,760,854 - 25,761,470UniSTSGRCm38
MGSCv37726,545,873 - 26,546,489UniSTSGRCm37
Celera720,369,766 - 20,370,382UniSTS
Cytogenetic Map7A3-B1UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301572Sluc30_msusceptibility to lung cancer 30 (mouse)Not determined7269777136697919Mouse
1300722Sle3_msystemic lupus erythmatosus susceptibility 3 (mouse)Not determined7346321287493512Mouse
38501068Tip1_mtuberculosis immunophenotype 1, spleen CFU (mouse)7360000072900000Mouse
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76500000133900000Mouse
1357699Nhdlq6_mnon-HDL QTL 6 (mouse)Not determined71028944244289559Mouse
1558893Spir1_mStreptococcus pneumoniae infection resistance 1 (mouse)Not determined71060637344606511Mouse
10449139Eosn1_meosinophil differential 1 (mouse)71278145246781452Mouse
10449158Eosn3_meosinophil differential 3 (mouse)71278145246781452Mouse
4141566Femwf8_mfemur work to failure 8 (mouse)Not determined1333306047333196Mouse
11522751Cocia17_mcocaine-induced activity, QTL 17 (mouse)71343577947435779Mouse
25314314Sccor1_msynaptonemal complex length to mean MLH1 count ratio 1 (mouse)71360000047700000Mouse
1559016Drsi_mDCC-related Spp1 induction (mouse)Not determined71690336849509583Mouse
1301041Prnr2_mprion resistance 2 (mouse)Not determined71899486940024609Mouse
10412199Sst2_msusceptibility to tuberculosis 2 (mouse)Not determined718994869119886157Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719413473142366067Mouse
1301622Eae12_msusceptibility to experimental allergic encephalomyelitis 12 (mouse)Not determined71958059053580679Mouse
1301052Bhr6_mbronchial hyperresponsiveness 6 (mouse)Not determined72014282554142942Mouse
12904742Litsq2_mlitter size QTL 2 (mouse)72302446357024609Mouse
1301709Bdt4_mbone density traits 4 (mouse)Not determined72323914857239292Mouse
11354952Pdcc1_mplasmacytoid dentritic cell compartment 1 (mouse)72341710757417107Mouse

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir34ammu-miR-34a-5pOncomiRDBexternal_infoNANA21814748
Mir34ammu-miR-34a-5pOncomiRDBexternal_infoNANA21317930
Mir199a-1mmu-miR-199a-5pOncomiRDBexternal_infoNANA21317930
Mir199bmmu-miR-199b-5pOncomiRDBexternal_infoNANA21317930

Predicted Target Of
Summary Value
Count of predictions:1654
Count of miRNA genes:669
Interacting mature miRNAs:831
Transcripts:ENSMUST00000002677, ENSMUST00000085948, ENSMUST00000124442, ENSMUST00000132038, ENSMUST00000132989, ENSMUST00000137211, ENSMUST00000137383, ENSMUST00000147680
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001190974 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001190975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_009465 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006539989 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006539991 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006539992 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006539993 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC119211 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC162614 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK033237 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK048382 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK155567 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK161294 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK170010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK170897 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK186931 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK199775 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK200128 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK200939 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC046618 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC050914 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC058230 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466593 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HI464136 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X59560 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X63535 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000002677   ⟹   ENSMUSP00000002677
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl725,757,273 - 25,788,687 (-)Ensembl
RefSeq Acc Id: ENSMUST00000085948   ⟹   ENSMUSP00000083110
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl725,757,630 - 25,788,705 (-)Ensembl
RefSeq Acc Id: ENSMUST00000124442
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl725,760,678 - 25,764,064 (-)Ensembl
RefSeq Acc Id: ENSMUST00000132038   ⟹   ENSMUSP00000114907
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl725,766,518 - 25,774,678 (-)Ensembl
RefSeq Acc Id: ENSMUST00000132989
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl725,763,794 - 25,788,700 (-)Ensembl
RefSeq Acc Id: ENSMUST00000137211
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl725,761,369 - 25,764,413 (-)Ensembl
RefSeq Acc Id: ENSMUST00000137383
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl725,785,939 - 25,787,572 (-)Ensembl
RefSeq Acc Id: ENSMUST00000147680
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl725,778,680 - 25,787,066 (-)Ensembl
RefSeq Acc Id: NM_001190974   ⟹   NP_001177903
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39725,455,925 - 25,488,158 (-)NCBI
GRCm38725,756,500 - 25,788,733 (-)ENTREZGENE
Celera720,365,412 - 20,397,704 (-)ENTREZGENE
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001190975   ⟹   NP_001177904
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39725,455,925 - 25,488,158 (-)NCBI
GRCm38725,756,500 - 25,788,733 (-)ENTREZGENE
Celera720,365,412 - 20,397,704 (-)ENTREZGENE
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_009465   ⟹   NP_033491
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39725,455,925 - 25,488,158 (-)NCBI
GRCm38725,756,500 - 25,788,733 (-)ENTREZGENE
MGSCv37726,542,292 - 26,573,560 (-)RGD
Celera720,365,412 - 20,397,704 (-)ENTREZGENE
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006539989   ⟹   XP_006540052
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39725,456,698 - 25,488,106 (-)NCBI
GRCm38725,757,273 - 25,788,693 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006539991   ⟹   XP_006540054
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39725,456,698 - 25,488,106 (-)NCBI
GRCm38725,757,273 - 25,788,693 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006539992   ⟹   XP_006540055
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39725,456,698 - 25,488,094 (-)NCBI
GRCm38725,757,273 - 25,788,669 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006539993   ⟹   XP_006540056
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39725,457,052 - 25,488,502 (-)NCBI
GRCm38725,757,273 - 25,788,924 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_033491   ⟸   NM_009465
- Peptide Label: isoform 1 precursor
- UniProtKB: Q00993 (UniProtKB/Swiss-Prot),   Q8CCF8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001177904   ⟸   NM_001190975
- Peptide Label: isoform 3 precursor
- Sequence:
RefSeq Acc Id: NP_001177903   ⟸   NM_001190974
- Peptide Label: isoform 2 precursor
- UniProtKB: Q6PE80 (UniProtKB/TrEMBL),   Q8CCF8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006540056   ⟸   XM_006539993
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_006540055   ⟸   XM_006539992
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_006540054   ⟸   XM_006539991
- Peptide Label: isoform X2
- UniProtKB: Q6PE80 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006540052   ⟸   XM_006539989
- Peptide Label: isoform X1
- UniProtKB: Q00993 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000083110   ⟸   ENSMUST00000085948
RefSeq Acc Id: ENSMUSP00000114907   ⟸   ENSMUST00000132038
RefSeq Acc Id: ENSMUSP00000002677   ⟸   ENSMUST00000002677
Promoters
RGD ID:6892308
Promoter ID:EPDNEW_M9605
Type:initiation region
Name:Axl_2
Description:Mus musculus AXL receptor tyrosine kinase , transcript variant3, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M9606  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38725,788,503 - 25,788,563EPDNEW
RGD ID:6892310
Promoter ID:EPDNEW_M9606
Type:initiation region
Name:Axl_1
Description:Mus musculus AXL receptor tyrosine kinase , transcript variant3, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M9605  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38725,788,677 - 25,788,737EPDNEW
RGD ID:6840676
Promoter ID:MM_KWN:49472
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lung,   MEF_B6
Transcripts:OTTMUST00000053097,   OTTMUST00000053098
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36726,549,241 - 26,549,741 (-)MPROMDB
RGD ID:6840675
Promoter ID:MM_KWN:49473
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_4Hour
Transcripts:OTTMUST00000074576
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36726,558,991 - 26,559,491 (-)MPROMDB
RGD ID:6840674
Promoter ID:MM_KWN:49474
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Lung,   MEF_B4,   MEF_B6
Transcripts:OTTMUST00000053095,   OTTMUST00000053096
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36726,572,036 - 26,573,097 (-)MPROMDB
RGD ID:6840677
Promoter ID:MM_KWN:49475
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Lung,   MEF_B4,   MEF_B6
Transcripts:OTTMUST00000053091,   OTTMUST00000053093,   UC009FTY.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36726,573,496 - 26,573,996 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1347244 AgrOrtholog
Ensembl Genes ENSMUSG00000002602 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000002677 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000083110 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSP00000114907 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000002677 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000085948 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000132038 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro FN3_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN3_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:26362 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1347244 ENTREZGENE
NCBI Gene 26362 ENTREZGENE
Pfam fn3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Axl PhenoGen
PRINTS TYRKINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE FN3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IG_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART FN3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00409 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TyrKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49265 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt F6YPR4_MOUSE UniProtKB/TrEMBL
  Q00993 ENTREZGENE
  Q3TTM4_MOUSE UniProtKB/TrEMBL
  Q6PE80 ENTREZGENE, UniProtKB/TrEMBL
  Q8CCF8 ENTREZGENE, UniProtKB/TrEMBL
  UFO_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q80YQ3 UniProtKB/Swiss-Prot