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Gene: Pdgfb (platelet derived growth factor, B polypeptide) Mus musculus
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Symbol: Pdgfb
Name: platelet derived growth factor, B polypeptide
Description: Predicted to have several functions, including molecular function regulator; platelet-derived growth factor binding activity; and protein dimerization activity. Involved in several processes, including animal organ development; nervous system development; and positive regulation of cell population proliferation. Predicted to localize to several cellular components, including basolateral plasma membrane; dendrite; and neuronal cell body. Is expressed in several structures, including alimentary system; cardiovascular system; extraembryonic component; female reproductive system; and nervous system. Human ortholog(s) of this gene implicated in basal ganglia calcification; clear cell renal cell carcinoma; connective tissue cancer (multiple); familial meningioma; and prostatic hypertrophy. Orthologous to human PDGFB (platelet derived growth factor subunit B); PARTICIPATES IN platelet-derived growth factor signaling pathway; sphingosine 1-phosphate signaling pathway; glioma pathway; INTERACTS WITH (S)-nicotine; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',5,5'-tetrabromobisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: c-sis; PDGF subunit B; PDGF-2; PDGF-B; platelet-derived growth factor B chain; platelet-derived growth factor beta polypeptide; platelet-derived growth factor subunit B; proto-oncogene c-Sis; Sis
Orthologs:
Homo sapiens (human) : PDGFB (platelet derived growth factor subunit B)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Pdgfb (platelet derived growth factor subunit B)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pdgfb (platelet derived growth factor subunit B)
Pan paniscus (bonobo/pygmy chimpanzee) : PDGFB (platelet derived growth factor subunit B)
Canis lupus familiaris (dog) : PDGFB (platelet derived growth factor subunit B)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pdgfb (platelet derived growth factor subunit B)
Sus scrofa (pig) : PDGFB (platelet derived growth factor subunit B)
Chlorocebus sabaeus (African green monkey) : PDGFB (platelet derived growth factor subunit B)
Heterocephalus glaber (naked mole-rat) : Pdgfb (platelet derived growth factor subunit B)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38.p6 Ensembl1579,995,874 - 80,014,977 (-)EnsemblGRCm38mm10GRCm38
GRCm381579,995,865 - 80,024,614 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371579,826,304 - 79,845,238 (-)NCBIGRCm37mm9NCBIm37
MGSCv361579,823,129 - 79,842,063 (-)NCBImm8
Celera1582,118,153 - 82,136,874 (-)NCBICelera
Cytogenetic Map15E1NCBI
cM Map1537.85NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Pdgfb
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 11068
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-07-28
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.