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Gene: Pdgfb (platelet derived growth factor, B polypeptide) Mus musculus
Symbol: Pdgfb
Name: platelet derived growth factor, B polypeptide
Description: Predicted to have several functions, including molecular function regulator; platelet-derived growth factor binding activity; and protein dimerization activity. Involved in several processes, including animal organ development; nervous system development; and positive regulation of cell population proliferation. Predicted to localize to several cellular components, including basolateral plasma membrane; dendrite; and neuronal cell body. Is expressed in several structures, including alimentary system; cardiovascular system; extraembryonic component; female reproductive system; and nervous system. Human ortholog(s) of this gene implicated in basal ganglia calcification; clear cell renal cell carcinoma; connective tissue cancer (multiple); familial meningioma; and prostatic hypertrophy. Orthologous to human PDGFB (platelet derived growth factor subunit B); PARTICIPATES IN platelet-derived growth factor signaling pathway; sphingosine 1-phosphate signaling pathway; glioma pathway; INTERACTS WITH (S)-nicotine; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',5,5'-tetrabromobisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: c-sis; PDGF subunit B; PDGF-2; PDGF-B; platelet-derived growth factor B chain; platelet-derived growth factor beta polypeptide; platelet-derived growth factor subunit B; proto-oncogene c-Sis; Sis
Homo sapiens (human) : PDGFB (platelet derived growth factor subunit B)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Pdgfb (platelet derived growth factor subunit B)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pdgfb (platelet derived growth factor subunit B)
Pan paniscus (bonobo/pygmy chimpanzee) : PDGFB (platelet derived growth factor subunit B)
Canis lupus familiaris (dog) : PDGFB (platelet derived growth factor subunit B)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pdgfb (platelet derived growth factor subunit B)
Sus scrofa (pig) : PDGFB (platelet derived growth factor subunit B)
Chlorocebus sabaeus (African green monkey) : PDGFB (platelet derived growth factor subunit B)
Heterocephalus glaber (naked mole-rat) : Pdgfb (platelet derived growth factor subunit B)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl1579,995,874 - 80,014,977 (-)EnsemblGRCm38mm10GRCm38
GRCm381579,995,865 - 80,024,614 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371579,826,304 - 79,845,238 (-)NCBIGRCm37mm9NCBIm37
MGSCv361579,823,129 - 79,842,063 (-)NCBImm8
Celera1582,118,153 - 82,136,874 (-)NCBICelera
Cytogenetic Map15E1NCBI
cM Map1537.85NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Pdgfb
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 11068
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.