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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:4-methylumbelliferone beta-D-glucuronide
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Accession:CHEBI:1904 term browser browse the term
Definition:A beta-D-glucosiduronic acid having a 4-methylumbelliferyl substituent at the anomeric position. A hyaluronan synthesis inhibitor, it is anti-tumourigenic for various malignant tumours.
Synonyms:exact_synonym: 4-methyl-2-oxo-2H-1-benzopyran-7-yl beta-D-glucopyranosiduronic acid
 related_synonym: 4-MUG;   4-Methylumbelliferone glucuronide;   4-Methylumbelliferyl beta-glucuronide;   4-Methylumbelliferyl glucuronide;   Formula=C16H16O9;   InChI=1S/C16H16O9/c1-6-4-10(17)24-9-5-7(2-3-8(6)9)23-16-13(20)11(18)12(19)14(25-16)15(21)22/h2-5,11-14,16,18-20H,1H3,(H,21,22)/t11-,12-,13+,14-,16+/m0/s1;   InChIKey=ARQXEQLMMNGFDU-JHZZJYKESA-N;   SMILES=O([C@@H]1O[C@@H]([C@@H](O)[C@H](O)[C@H]1O)C(=O)O)C2=CC3=C(C(=CC(O3)=O)C)C=C2
 xref: CAS:6160-80-1;   KEGG:C11584
 xref_mesh: MESH:C034888
 xref: PMID:21401602;   PMID:21512263;   PMID:27218304;   PMID:27833847;   PMID:28054956;   PMID:28116598;   PMID:28479734;   PMID:29846918;   PMID:30914479;   Reaxys:53625
 cyclic_relationship: is_conjugate_acid_of CHEBI:144582


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4-methylumbelliferone beta-D-glucuronide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ugt1a1 UDP glucuronosyltransferase 1 family, polypeptide A1 multiple interactions ISO [UGT1A1 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; pterostilbene inhibits the reaction [[UGT1A1 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide] CTD PMID:31812603 NCBI chr 1:88,211,959...88,220,002
Ensembl chr 1:88,211,959...88,218,997
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 multiple interactions ISO [UGT1A3 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; pterostilbene inhibits the reaction [[UGT1A3 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide] CTD PMID:31812603 NCBI chr 1:88,200,611...88,220,002
Ensembl chr 1:88,200,601...88,218,997
JBrowse link
G Ugt1a6b UDP glucuronosyltransferase 1 family, polypeptide A6B multiple interactions ISO [UGT1A6 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; pterostilbene inhibits the reaction [[UGT1A6 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide] CTD PMID:31812603 NCBI chr 1:88,103,257...88,218,998
Ensembl chr 1:88,103,252...88,219,003
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase 1 family, polypeptide A9 multiple interactions ISO [UGT1A9 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; pterostilbene inhibits the reaction [[UGT1A9 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide] CTD PMID:31812603 NCBI chr 1:88,070,779...88,220,002
Ensembl chr 1:88,070,800...88,218,997
JBrowse link
G Ugt2b34 UDP glucuronosyltransferase 2 family, polypeptide B34 multiple interactions ISO [UGT2B7 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; pterostilbene inhibits the reaction [[UGT2B7 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide] CTD PMID:31812603 NCBI chr 5:86,889,770...86,906,937
Ensembl chr 5:86,889,767...86,906,937
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 21569
    role 21548
      biological role 21546
        inhibitor 19299
          hyaluronan synthesis inhibitor 5
            4-methylumbelliferone beta-D-glucuronide 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 21569
    subatomic particle 21555
      composite particle 21555
        hadron 21555
          baryon 21555
            nucleon 21555
              atomic nucleus 21555
                atom 21555
                  main group element atom 21461
                    p-block element atom 21461
                      carbon group element atom 21254
                        carbon atom 21151
                          organic molecular entity 21151
                            organic molecule 21045
                              organic cyclic compound 20601
                                organic heterocyclic compound 19451
                                  oxacycle 17573
                                    benzopyran 10457
                                      1-benzopyran 10179
                                        chromenes 934
                                          chromenone 864
                                            coumarins 580
                                              hydroxycoumarin 309
                                                umbelliferone 80
                                                  4-methylumbelliferone 23
                                                    4-methylumbelliferone beta-D-glucuronide 5
paths to the root