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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:chromenes
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Accession:CHEBI:23232 term browser browse the term



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2-[4-[(E)-2-(6,8-dichloro-2-phenyl-2H-chromen-3-yl)ethenyl]phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nphs1 NPHS1 adhesion molecule, nephrin increases expression ISO BD4 increases expression of Nphs1 mRNA in podocytes RGD PMID:22125642 RGD:40902998 NCBI chr 1:85,720,812...85,749,079
Ensembl chr 1:85,720,812...85,749,078
JBrowse link
G Synpo synaptopodin increases expression ISO BD4 increases expression of Synpo mRNA in podocytes RGD PMID:22125642 RGD:40902998 NCBI chr18:54,048,299...54,106,388
Ensembl chr18:54,026,152...54,102,126
JBrowse link
3,4-dihydrocoumarin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ddit3 DNA-damage inducible transcript 3 affects expression ISO 3,4-dihydrocoumarin affects the expression of DDIT3 mRNA CTD PMID:22016648 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Dnaja2 DnaJ heat shock protein family (Hsp40) member A2 decreases expression ISO 3,4-dihydrocoumarin results in decreased expression of DNAJA2 mRNA CTD PMID:22016648 NCBI chr19:21,497,792...21,516,904
Ensembl chr19:21,497,729...21,516,901
JBrowse link
G Egf epidermal growth factor increases expression ISO 3,4-dihydrocoumarin results in increased expression of EGF mRNA CTD PMID:22016648 NCBI chr 2:218,219,408...218,302,370
Ensembl chr 2:218,219,415...218,302,064
JBrowse link
G Ephx1 epoxide hydrolase 1 decreases expression ISO 3,4-dihydrocoumarin results in decreased expression of EPHX1 mRNA CTD PMID:22016648 NCBI chr13:92,714,315...92,744,124
Ensembl chr13:92,714,315...92,790,235
JBrowse link
G Hsd17b4 hydroxysteroid (17-beta) dehydrogenase 4 increases expression ISO 3,4-dihydrocoumarin results in increased expression of HSD17B4 mRNA CTD PMID:22016648 NCBI chr18:43,328,903...43,417,950
Ensembl chr18:43,328,824...43,417,952
JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 decreases expression ISO 3,4-dihydrocoumarin results in decreased expression of HSP90AB1 mRNA CTD PMID:22016648 NCBI chr 9:15,432,986...15,438,358
Ensembl chr 9:15,433,691...15,438,488
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A increases expression ISO 3,4-dihydrocoumarin results in increased expression of HSPA1A mRNA CTD PMID:22016648
G Oat ornithine aminotransferase decreases expression ISO 3,4-dihydrocoumarin results in decreased expression of OAT mRNA CTD PMID:22016648 NCBI chr 1:187,347,862...187,367,644
Ensembl chr 1:187,347,865...187,367,682
JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 decreases expression ISO 3,4-dihydrocoumarin results in decreased expression of PCK1 mRNA CTD PMID:22016648 NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191
JBrowse link
G Pon1 paraoxonase 1 affects metabolic processing ISO PON1 SNP affects the metabolism of 3,4-dihydrocoumarin CTD PMID:25027835 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360
JBrowse link
G Prdx1 peroxiredoxin 1 increases expression ISO 3,4-dihydrocoumarin results in increased expression of PRDX1 mRNA CTD PMID:22016648 NCBI chr 5:130,147,276...130,162,850
Ensembl chr 5:130,147,204...130,162,856
JBrowse link
G Prdx3 peroxiredoxin 3 decreases expression ISO 3,4-dihydrocoumarin results in decreased expression of PRDX3 mRNA CTD PMID:22016648 NCBI chr 1:260,001,642...260,014,064
Ensembl chr 1:260,001,637...260,014,111
JBrowse link
G Psmb8 proteasome 20S subunit beta 8 decreases expression ISO 3,4-dihydrocoumarin results in decreased expression of PSMB8 mRNA CTD PMID:22016648 NCBI chr20:4,652,159...4,655,122
Ensembl chr20:4,652,159...4,655,283
JBrowse link
G Ptpmt1 protein tyrosine phosphatase, mitochondrial 1 decreases expression ISO 3,4-dihydrocoumarin results in decreased expression of PTPMT1 mRNA CTD PMID:22016648 NCBI chr 3:76,889,922...76,899,427
Ensembl chr 3:76,889,922...76,899,427
JBrowse link
G Rbp4 retinol binding protein 4 decreases expression ISO 3,4-dihydrocoumarin results in decreased expression of RBP4 mRNA CTD PMID:22016648 NCBI chr 1:235,893,917...235,901,315
Ensembl chr 1:235,893,917...235,901,399
JBrowse link
G Sod1 superoxide dismutase 1 decreases expression ISO 3,4-dihydrocoumarin results in decreased expression of SOD1 mRNA CTD PMID:22016648 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 decreases expression ISO 3,4-dihydrocoumarin results in decreased expression of TIMP2 mRNA CTD PMID:22016648 NCBI chr10:103,541,199...103,590,611 JBrowse link
G Tubb5 tubulin, beta 5 class I decreases expression ISO 3,4-dihydrocoumarin results in decreased expression of TUBB5 mRNA CTD PMID:22016648 NCBI chr20:2,912,779...2,916,928
Ensembl chr20:2,912,778...2,916,940
JBrowse link
4-hydroxycoumarin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrm1 ADRM1 26S proteasome ubiquitin receptor decreases expression ISO 4-hydroxycoumarin results in decreased expression of ADRM1 mRNA CTD PMID:18492274 NCBI chr 3:167,265,435...167,270,197
Ensembl chr 3:167,265,296...167,270,195
JBrowse link
G Glo1 glyoxalase 1 decreases activity ISO 4-hydroxycoumarin analog results in decreased activity of GLO1 protein CTD PMID:33989593 NCBI chr20:8,663,617...8,681,661
Ensembl chr20:8,662,801...8,681,649
JBrowse link
G Ptk2 protein tyrosine kinase 2 decreases phosphorylation ISO 4-hydroxycoumarin results in decreased phosphorylation of PTK2 protein CTD PMID:18492274 NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783
JBrowse link
G Pxn paxillin decreases expression
decreases phosphorylation
affects localization
ISO 4-hydroxycoumarin results in decreased expression of PXN mRNA alternative form; 4-hydroxycoumarin results in decreased expression of PXN protein alternative form
4-hydroxycoumarin results in decreased phosphorylation of PXN protein
4-hydroxycoumarin affects the localization of PXN protein
CTD PMID:18492274 NCBI chr12:41,060,791...41,107,962
Ensembl chr12:41,060,791...41,107,931
JBrowse link
G Rac1 Rac family small GTPase 1 decreases expression ISO 4-hydroxycoumarin results in decreased expression of RAC1 protein CTD PMID:18492274 NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251
JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 increases metabolic processing
affects metabolic processing
EXP UGT1A6 protein results in increased metabolism of 4-hydroxycoumarin
UGT1A6 gene polymorphism affects the metabolism of 4-hydroxycoumarin
CTD PMID:9429234 NCBI chr 9:88,747,229...88,808,465 JBrowse link
G Vkorc1 vitamin K epoxide reductase complex, subunit 1 decreases activity
multiple interactions
ISO 4-hydroxycoumarin results in decreased activity of VKORC1 protein
4-hydroxycoumarin inhibits the reaction [VKORC1 protein results in increased reduction of Vitamin K 1]
CTD PMID:29581108 NCBI chr 1:182,502,491...182,505,012
Ensembl chr 1:182,500,844...182,505,008
JBrowse link
G Vkorc1l1 vitamin K epoxide reductase complex, subunit 1-like 1 multiple interactions
decreases activity
ISO 4-hydroxycoumarin inhibits the reaction [VKORC1L1 protein results in increased reduction of Vitamin K 1]
4-hydroxycoumarin results in decreased activity of VKORC1L1 protein
CTD PMID:29581108 NCBI chr12:26,717,959...26,768,193 JBrowse link
4-methylumbelliferone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg2 ATP binding cassette subfamily G member 2 affects export ISO ABCG2 protein affects the export of Hymecromone analog CTD PMID:15598971 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions ISO Hymecromone inhibits the reaction [Dietary Fats results in decreased expression of ADIPOQ protein] CTD PMID:24661945 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
JBrowse link
G Cat catalase multiple interactions ISO Hymecromone inhibits the reaction [Dietary Fats results in decreased activity of CAT protein] CTD PMID:24661945 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO Hymecromone inhibits the reaction [Dietary Fats results in increased activity of CYP2E1 protein] CTD PMID:24661945 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 increases sulfation ISO
EXP
SULT1A1 protein results in increased sulfation of Hymecromone CTD PMID:11181495 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 multiple interactions
increases metabolic processing
increases activity
increases glucuronidation
ISO [UGT1A1 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; [UGT1A1 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; belinostat inhibits the reaction [[UGT1A1 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; belinostat inhibits the reaction [UGT1A1 protein results in increased glucuronidation of Hymecromone]; Diclofenac inhibits the reaction [[UGT1A1 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; Diclofenac inhibits the reaction [UGT1A1 protein results in increased glucuronidation of Hymecromone]; Estradiol promotes the reaction [UGT1A1 protein results in increased glucuronidation of Hymecromone]; licochalcone A inhibits the reaction [Hymecromone results in increased activity of UGT1A1 protein]; pterostilbene inhibits the reaction [[UGT1A1 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide] CTD PMID:15378558 PMID:15593333 PMID:15802387 PMID:26875642 PMID:31812603 More... NCBI chr 9:88,801,344...88,808,465 JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases activity
increases metabolic processing
multiple interactions
increases glucuronidation
ISO Hymecromone results in increased activity of UGT1A3 protein
UGT1A3 protein results in increased metabolism of Hymecromone
[UGT1A3 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; [UGT1A3 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; Androsterone inhibits the reaction [[UGT1A3 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; Androsterone inhibits the reaction [UGT1A3 protein results in increased glucuronidation of Hymecromone]; belinostat inhibits the reaction [[UGT1A3 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; belinostat inhibits the reaction [UGT1A3 protein results in increased glucuronidation of Hymecromone]; licochalcone A inhibits the reaction [Hymecromone results in increased activity of UGT1A3 protein]; pterostilbene inhibits the reaction [[UGT1A3 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]
CTD PMID:15802387 PMID:26875642 PMID:31812603 PMID:33290829 NCBI chr 9:88,791,216...88,808,465 JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 affects metabolic processing
increases metabolic processing
increases activity
multiple interactions
increases glucuronidation
EXP
ISO
UGT1A6 gene polymorphism affects the metabolism of Hymecromone
UGT1A6 protein results in increased metabolism of Hymecromone
Hymecromone results in increased activity of UGT1A6 protein
[UGT1A6 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; [UGT1A6 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; belinostat inhibits the reaction [[UGT1A6 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; belinostat inhibits the reaction [UGT1A6 protein results in increased glucuronidation of Hymecromone]; bisphenol A inhibits the reaction [UGT1A6 protein results in increased glucuronidation of Hymecromone]; Diclofenac inhibits the reaction [[UGT1A6 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; Diclofenac inhibits the reaction [UGT1A6 protein results in increased glucuronidation of Hymecromone]; licochalcone A inhibits the reaction [Hymecromone results in increased activity of UGT1A6 protein]; pterostilbene inhibits the reaction [[UGT1A6 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]
CTD PMID:9429234 PMID:15802387 PMID:18214896 PMID:25393417 PMID:26875642 More... NCBI chr 9:88,747,229...88,808,465 JBrowse link
G Ugt1a7c UDP glucuronosyltransferase 1 family, polypeptide A7C increases glucuronidation EXP UGT1A7 protein results in increased glucuronidation of Hymecromone CTD PMID:15502008 NCBI chr 9:88,739,577...88,808,465 JBrowse link
G Ugt1a8 UDP glucuronosyltransferase family 1 member A8 multiple interactions
increases activity
increases glucuronidation
increases metabolic processing
ISO
EXP
[UGT1A8 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; [UGT1A8 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; belinostat inhibits the reaction [[UGT1A8 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; belinostat inhibits the reaction [UGT1A8 protein results in increased glucuronidation of Hymecromone]; licochalcone A inhibits the reaction [Hymecromone results in increased activity of UGT1A8 protein]; Phenylbutazone inhibits the reaction [[UGT1A8 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; Phenylbutazone inhibits the reaction [UGT1A8 protein results in increased glucuronidation of Hymecromone]; Propofol promotes the reaction [UGT1A8 protein results in increased glucuronidation of Hymecromone]; pterostilbene inhibits the reaction [[UGT1A8 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide] CTD PMID:15378558 PMID:15502008 PMID:15802387 PMID:26875642 PMID:31812603 More... NCBI chr 9:88,727,094...88,808,465 JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation
increases metabolic processing
increases activity
multiple interactions
ISO UGT1A9 protein results in increased glucuronidation of Hymecromone
UGT1A9 protein results in increased metabolism of Hymecromone
Hymecromone results in increased activity of UGT1A9 protein
[UGT1A9 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; [UGT1A9 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; Diclofenac inhibits the reaction [[UGT1A9 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; Diclofenac inhibits the reaction [UGT1A9 protein results in increased glucuronidation of Hymecromone]; licochalcone A inhibits the reaction [Hymecromone results in increased activity of UGT1A9 protein]; pterostilbene inhibits the reaction [[UGT1A9 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]
CTD PMID:15378558 PMID:15802387 PMID:26875642 PMID:31812603 PMID:33290829 NCBI chr 9:88,696,981...88,808,465 JBrowse link
G Ugt2a1 UDP glucuronosyltransferase family 2 member A1 increases glucuronidation ISO UGT2A1 protein results in increased glucuronidation of Hymecromone CTD PMID:21164388 NCBI chr14:20,521,018...20,545,060
Ensembl chr14:20,517,951...20,545,531
JBrowse link
G Ugt2b15 UDP glucuronosyltransferase family 2 member B15 increases metabolic processing EXP UGT2B15 protein results in increased metabolism of Hymecromone CTD PMID:7574722 NCBI chr14:20,768,015...20,783,599
Ensembl chr14:20,768,015...20,783,589
JBrowse link
G Ugt2b17 UDP glucuronosyltransferase family 2 member B17 increases glucuronidation
increases activity
increases metabolic processing
multiple interactions
EXP
ISO
UGT2B1 protein results in increased glucuronidation of Hymecromone
UGT2B17 protein results in increased glucuronidation of Hymecromone
Hymecromone results in increased activity of UGT2B17 protein
UGT2B17 protein results in increased metabolism of Hymecromone
[UGT2B17 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; licochalcone A inhibits the reaction [Hymecromone results in increased activity of UGT2B17 protein]
CTD PMID:8302279 PMID:8798464 PMID:26875642 PMID:33290829 NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986
JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 increases activity
increases glucuronidation
increases metabolic processing
multiple interactions
ISO Hymecromone results in increased activity of UGT2B7 protein
UGT2B7 protein results in increased glucuronidation of Hymecromone
UGT2B7 protein results in increased metabolism of Hymecromone
[UGT2B7 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; [UGT2B7 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; Androsterone inhibits the reaction [[UGT2B7 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; Androsterone inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Hymecromone]; belinostat inhibits the reaction [[UGT2B7 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; belinostat inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Hymecromone]; licochalcone A inhibits the reaction [Hymecromone results in increased activity of UGT2B7 protein]; pterostilbene inhibits the reaction [[UGT2B7 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]
CTD PMID:26875642 PMID:31812603 PMID:33290829 NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604
JBrowse link
4-methylumbelliferone beta-D-glucuronide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 multiple interactions ISO [UGT1A1 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; [UGT1A1 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; belinostat inhibits the reaction [[UGT1A1 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; Diclofenac inhibits the reaction [[UGT1A1 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; pterostilbene inhibits the reaction [[UGT1A1 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide] CTD PMID:31812603 PMID:33290829 NCBI chr 9:88,801,344...88,808,465 JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 multiple interactions ISO [UGT1A3 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; [UGT1A3 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; Androsterone inhibits the reaction [[UGT1A3 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; belinostat inhibits the reaction [[UGT1A3 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; pterostilbene inhibits the reaction [[UGT1A3 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide] CTD PMID:31812603 PMID:33290829 NCBI chr 9:88,791,216...88,808,465 JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 multiple interactions ISO [UGT1A6 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; [UGT1A6 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; belinostat inhibits the reaction [[UGT1A6 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; Diclofenac inhibits the reaction [[UGT1A6 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; pterostilbene inhibits the reaction [[UGT1A6 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide] CTD PMID:31812603 PMID:33290829 NCBI chr 9:88,747,229...88,808,465 JBrowse link
G Ugt1a8 UDP glucuronosyltransferase family 1 member A8 multiple interactions ISO [UGT1A8 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; [UGT1A8 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; belinostat inhibits the reaction [[UGT1A8 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; Phenylbutazone inhibits the reaction [[UGT1A8 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; pterostilbene inhibits the reaction [[UGT1A8 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide] CTD PMID:31812603 PMID:33290829 NCBI chr 9:88,727,094...88,808,465 JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 multiple interactions ISO [UGT1A9 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; [UGT1A9 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; Diclofenac inhibits the reaction [[UGT1A9 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; pterostilbene inhibits the reaction [[UGT1A9 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide] CTD PMID:31812603 PMID:33290829 NCBI chr 9:88,696,981...88,808,465 JBrowse link
G Ugt2b17 UDP glucuronosyltransferase family 2 member B17 multiple interactions ISO [UGT2B17 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide CTD PMID:33290829 NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986
JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 multiple interactions ISO [UGT2B7 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; [UGT2B7 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; Androsterone inhibits the reaction [[UGT2B7 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; belinostat inhibits the reaction [[UGT2B7 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; pterostilbene inhibits the reaction [[UGT2B7 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide] CTD PMID:31812603 PMID:33290829 NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604
JBrowse link
4-methylumbelliferone sulfate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc22a25 solute carrier family 22, member 25 multiple interactions EXP 4-methylumbelliferyl sulfate inhibits the reaction [SLC22A9 protein affects the transport of estrone sulfate] CTD PMID:18441515 NCBI chr 1:205,338,698...205,498,486
Ensembl chr 1:205,338,699...205,433,085
JBrowse link
4-methylumbelliferyl acetate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Calr calreticulin increases activity ISO 4-methylumbelliferyl acetate results in increased activity of CALR protein CTD PMID:20188080 NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414
JBrowse link
G Ces1d carboxylesterase 1D multiple interactions
increases hydrolysis
ISO Atropine inhibits the reaction [CES1 protein results in increased hydrolysis of 4-methylumbelliferyl acetate]; Cocaine inhibits the reaction [CES1 protein results in increased hydrolysis of 4-methylumbelliferyl acetate]; tropacocaine inhibits the reaction [CES1 protein results in increased hydrolysis of 4-methylumbelliferyl acetate] CTD PMID:9311626 NCBI chr19:13,873,490...13,912,035 JBrowse link
G Ces2h carboxylesterase 2H increases hydrolysis ISO CES2 protein results in increased hydrolysis of 4-methylumbelliferyl acetate CTD PMID:9169443 NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830
JBrowse link
G Txn1 thioredoxin 1 increases activity ISO 4-methylumbelliferyl acetate results in increased activity of TXN protein CTD PMID:24103856 NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO 4-methylumbelliferyl acetate results in increased expression of VEGFA protein CTD PMID:24103856 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
4-methylumbelliferyl beta-D-galactoside term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ca12 carbonic anhydrase 12 decreases activity ISO 4-methylumbelliferyl-galactopyranoside analog results in decreased activity of CA12 protein CTD PMID:22077347 NCBI chr 8:67,274,739...67,330,428
Ensembl chr 8:67,274,359...67,330,440
JBrowse link
G Ca9 carbonic anhydrase 9 decreases activity ISO 4-methylumbelliferyl-galactopyranoside analog results in decreased activity of CA9 protein CTD PMID:22077347 NCBI chr 5:57,763,234...57,769,838
Ensembl chr 5:57,763,206...57,769,838
JBrowse link
4-methylumbelliferyl beta-D-glucoside term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gaa alpha glucosidase multiple interactions
increases metabolic processing
ISO GAA gene SNP inhibits the reaction [GAA protein results in increased metabolism of 4-methylumbelliferyl glucoside] CTD PMID:21963784 NCBI chr10:104,529,673...104,546,836
Ensembl chr10:104,529,747...104,546,836
JBrowse link
4-phenylcoumarin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase increases expression ISO 4-phenylcoumarin analog results in increased expression of ABL1 mRNA CTD PMID:27773722 NCBI chr 3:14,979,853...15,083,065
Ensembl chr 3:14,979,853...15,083,065
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO 4-phenylcoumarin analog results in increased expression of DDIT3 mRNA CTD PMID:27773722 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression ISO 4-phenylcoumarin analog results in increased expression of GADD45A mRNA CTD PMID:27773722 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
JBrowse link
G Gadd45g growth arrest and DNA-damage-inducible, gamma increases expression ISO 4-phenylcoumarin analog results in increased expression of GADD45G mRNA CTD PMID:27773722 NCBI chr17:13,376,842...13,378,587
Ensembl chr17:13,376,839...13,378,610
JBrowse link
G Mlh3 mutL homolog 3 increases expression ISO 4-phenylcoumarin analog results in increased expression of MLH3 mRNA CTD PMID:27773722 NCBI chr 6:104,881,483...104,917,686
Ensembl chr 6:104,881,483...104,917,728
JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A increases expression ISO 4-phenylcoumarin analog results in increased expression of PPP1R15A mRNA CTD PMID:27773722 NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171
JBrowse link
7,8-dihydroxycoumarin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin multiple interactions EXP daphnetin inhibits the reaction [Benzene results in decreased expression of ALB protein] CTD PMID:33749080 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO daphnetin inhibits the reaction [sodium arsenite results in increased expression of BAX protein] CTD PMID:30738023 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO daphnetin inhibits the reaction [sodium arsenite results in decreased expression of BCL2 protein] CTD PMID:30738023 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions EXP daphnetin inhibits the reaction [Benzene results in increased expression of CYP2E1 mRNA] CTD PMID:33749080 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO daphnetin results in increased expression of GCLC protein CTD PMID:30738023 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO daphnetin results in increased expression of GCLM protein CTD PMID:30738023 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP daphnetin inhibits the reaction [Benzene results in increased expression of GPT protein] CTD PMID:33749080 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
ISO daphnetin results in increased expression of HMOX1 protein
[sodium arsenite co-treated with daphnetin] results in increased expression of HMOX1 protein; NFE2L2 protein affects the reaction [daphnetin results in increased expression of HMOX1 protein]
CTD PMID:30738023 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP daphnetin inhibits the reaction [Benzene results in increased expression of IL1B protein] CTD PMID:33749080 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il2 interleukin 2 multiple interactions EXP daphnetin inhibits the reaction [Benzene results in increased expression of IL2 protein] CTD PMID:33749080 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il6 interleukin 6 multiple interactions EXP daphnetin inhibits the reaction [Benzene results in increased expression of IL6 protein] CTD PMID:33749080 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 decreases expression ISO daphnetin results in decreased expression of KEAP1 protein CTD PMID:30738023 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO daphnetin results in increased phosphorylation of MAPK1 protein CTD PMID:30738023 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO daphnetin results in increased phosphorylation of MAPK3 protein CTD PMID:30738023 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO [sodium arsenite co-treated with daphnetin] results in increased expression of NFE2L2 protein; daphnetin results in increased expression of and affects the localization of NFE2L2 protein; NFE2L2 protein affects the reaction [daphnetin results in increased expression of HMOX1 protein] CTD PMID:30738023 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO daphnetin results in increased expression of NQO1 protein CTD PMID:30738023 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G S1pr1 sphingosine-1-phosphate receptor 1 multiple interactions EXP daphnetin inhibits the reaction [Benzene results in increased expression of S1PR1 mRNA] CTD PMID:33749080 NCBI chr 2:203,624,752...203,629,110
Ensembl chr 2:203,621,587...203,629,681
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP daphnetin inhibits the reaction [Benzene results in increased expression of TNF protein] CTD PMID:33749080 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
7-ethoxycoumarin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases metabolic processing ISO CYP2E1 protein results in increased metabolism of 7-ethoxycoumarin CTD PMID:18385292 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
7-hydroxycoumarin O(7)-glucosiduronic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ugt2b15 UDP glucuronosyltransferase family 2 member B15 increases abundance EXP UGT2B15 protein results in increased abundance of 7-hydroxycoumarin glucuronide CTD PMID:7574722 NCBI chr14:20,768,015...20,783,599
Ensembl chr14:20,768,015...20,783,589
JBrowse link
acenocoumarol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A affects response to substance ISO ABCB1 gene polymorphism affects the susceptibility to Acenocoumarol CTD PMID:18021343 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Apoe apolipoprotein E affects response to substance ISO APOE gene polymorphism affects the susceptibility to Acenocoumarol CTD PMID:15861030 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 affects metabolic processing ISO CYP1A1 protein affects the metabolism of Acenocoumarol CTD PMID:11918509 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 affects metabolic processing ISO CYP1A2 protein affects the metabolism of Acenocoumarol CTD PMID:11918509 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp2c24 cytochrome P450, family 2, subfamily c, polypeptide 24 affects response to substance ISO CYP2C18 gene polymorphism affects the susceptibility to Acenocoumarol CTD PMID:19578179 NCBI chr 1:236,873,967...236,936,238
Ensembl chr 1:236,873,967...236,936,238
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 affects metabolic processing ISO CYP2C19 protein affects the metabolism of Acenocoumarol CTD PMID:11918509 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G F10 coagulation factor X decreases activity EXP Acenocoumarol results in decreased activity of F10 protein CTD PMID:3490277 NCBI chr16:76,468,834...76,488,141
Ensembl chr16:76,468,838...76,488,141
JBrowse link
G F2 coagulation factor II decreases activity EXP Acenocoumarol results in decreased activity of F2 protein CTD PMID:3490277 NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486
JBrowse link
G F5 coagulation factor V decreases activity EXP Acenocoumarol results in decreased activity of F5 protein CTD PMID:3490277 NCBI chr13:76,513,463...76,583,106
Ensembl chr13:76,513,255...76,582,317
JBrowse link
G F7 coagulation factor VII decreases activity EXP Acenocoumarol results in decreased activity of F7 protein CTD PMID:3490277 NCBI chr16:76,489,779...76,500,636
Ensembl chr16:76,489,717...76,500,610
JBrowse link
G F9 coagulation factor IX decreases activity EXP Acenocoumarol results in decreased activity of F9 protein CTD PMID:3490277 NCBI chr  X:138,352,334...138,396,835
Ensembl chr  X:138,352,298...138,396,835
JBrowse link
G Ggcx gamma-glutamyl carboxylase increases activity EXP Acenocoumarol results in increased activity of GGCX protein CTD PMID:3490277 NCBI chr 4:104,469,737...104,485,631
Ensembl chr 4:104,469,765...104,487,063
JBrowse link
G Vkorc1 vitamin K epoxide reductase complex, subunit 1 decreases response to substance
decreases activity
multiple interactions
affects response to substance
increases response to substance
ISO VKORC1 promoter polymorphism results in decreased susceptibility to Acenocoumarol; VKORC1 protein polymorphism results in decreased susceptibility to Acenocoumarol
Acenocoumarol results in decreased activity of VKORC1 protein
Acenocoumarol inhibits the reaction [VKORC1 protein results in increased reduction of Vitamin K 1]
VKORC1 gene polymorphism affects the susceptibility to Acenocoumarol; VKORC1 gene SNP affects the susceptibility to Acenocoumarol; VKORC1 intron SNP affects the susceptibility to Acenocoumarol; VKORC1 polymorphism affects the susceptibility to Acenocoumarol; VKORC1 protein polymorphism affects the susceptibility to Acenocoumarol
VKORC1 protein results in increased susceptibility to Acenocoumarol
CTD PMID:16201835 PMID:16611310 PMID:16869821 PMID:17036862 PMID:18698879 More... NCBI chr 1:182,502,491...182,505,012
Ensembl chr 1:182,500,844...182,505,008
JBrowse link
G Vkorc1l1 vitamin K epoxide reductase complex, subunit 1-like 1 multiple interactions
decreases activity
ISO Acenocoumarol inhibits the reaction [VKORC1L1 protein results in increased reduction of Vitamin K 1]
Acenocoumarol results in decreased activity of VKORC1L1 protein
CTD PMID:29581108 NCBI chr12:26,717,959...26,768,193 JBrowse link
Aflatoxin G1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atm ATM serine/threonine kinase increases expression
increases activity
multiple interactions
ISO aflatoxin G1 results in increased expression of ATM protein modified form
aflatoxin G1 results in increased activity of ATM protein
Methoxsalen inhibits the reaction [aflatoxin G1 results in increased expression of ATM protein modified form]; Nicotine inhibits the reaction [aflatoxin G1 results in increased expression of ATM protein modified form]
CTD PMID:23907605 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
JBrowse link
G Atr ATR serine/threonine kinase increases expression
multiple interactions
increases activity
ISO aflatoxin G1 results in increased expression of ATR protein modified form
Methoxsalen inhibits the reaction [aflatoxin G1 results in increased expression of ATR protein modified form]; Nicotine inhibits the reaction [aflatoxin G1 results in increased expression of ATR protein modified form]
aflatoxin G1 results in increased activity of ATR protein
CTD PMID:23907605 NCBI chr 8:96,426,704...96,524,152
Ensembl chr 8:96,426,724...96,524,136
JBrowse link
G Brca1 BRCA1, DNA repair associated increases activity
multiple interactions
increases expression
ISO aflatoxin G1 results in increased activity of BRCA1 protein
Methoxsalen inhibits the reaction [aflatoxin G1 results in increased expression of BRCA1 protein modified form]; Nicotine inhibits the reaction [aflatoxin G1 results in increased expression of BRCA1 protein modified form]
CTD PMID:23907605 NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304
JBrowse link
G Casp3 caspase 3 increases expression
multiple interactions
ISO aflatoxin G1 results in increased expression of CASP3 protein modified form
Methoxsalen inhibits the reaction [aflatoxin G1 results in increased expression of CASP3 protein modified form]; Nicotine inhibits the reaction [aflatoxin G1 results in increased expression of CASP3 protein modified form]
CTD PMID:23907605 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression ISO aflatoxin G1 results in increased expression of CCL2 mRNA CTD PMID:25445582 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Chek2 checkpoint kinase 2 multiple interactions
increases expression
increases activity
ISO Methoxsalen inhibits the reaction [aflatoxin G1 results in increased expression of CHEK2 protein modified form]; Nicotine inhibits the reaction [aflatoxin G1 results in increased expression of CHEK2 protein modified form]
aflatoxin G1 results in increased activity of CHEK2 protein
CTD PMID:23907605 NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 increases expression ISO aflatoxin G1 results in increased expression of CXCL2 mRNA CTD PMID:25445582 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 increases expression ISO aflatoxin G1 results in increased expression of CXCL1 mRNA CTD PMID:25445582 NCBI chr14:17,270,146...17,289,458
Ensembl chr14:17,270,146...17,289,511
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases response to substance ISO CYP1A2 protein results in increased susceptibility to aflatoxin G1 CTD PMID:11189750 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp2a1 cytochrome P450, family 2, subfamily a, polypeptide 1 increases activity
affects response to substance
ISO CYP2A13 protein results in increased activity of aflatoxin G1
CYP2A13 protein affects the susceptibility to aflatoxin G1
CTD PMID:23907605 NCBI chr 1:82,231,611...82,244,887
Ensembl chr 1:82,231,611...82,244,887
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 affects metabolic processing
multiple interactions
increases expression
increases response to substance
ISO CYP3A4 protein affects the metabolism of aflatoxin G1
aflatoxin G1 promotes the reaction [NR1I2 protein binds to CYP3A4 promoter]
aflatoxin G1 results in increased expression of CYP3A4 mRNA
CYP3A4 protein results in increased susceptibility to aflatoxin G1
CTD PMID:2271712 PMID:2655891 PMID:11189750 PMID:21641981 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases response to substance ISO CYP3A5 protein results in increased susceptibility to aflatoxin G1 CTD PMID:11189750 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
JBrowse link
G H2ax H2A.X variant histone increases expression
multiple interactions
ISO aflatoxin G1 results in increased expression of H2AX protein modified form
Methoxsalen inhibits the reaction [aflatoxin G1 results in increased expression of H2AX protein modified form]; Nicotine inhibits the reaction [aflatoxin G1 results in increased expression of H2AX protein modified form]
CTD PMID:23907605 NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO aflatoxin G1 results in increased expression of HMOX1 protein CTD PMID:25445582 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Il10 interleukin 10 multiple interactions ISO aflatoxin G1 inhibits the reaction [Lipopolysaccharides results in increased secretion of IL10 protein] CTD PMID:22445859 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il12b interleukin 12B multiple interactions ISO [aflatoxin G1 co-treated with Aflatoxin B1] inhibits the reaction [Lipopolysaccharides results in increased secretion of IL12B protein]; [aflatoxin G1 co-treated with aflatoxin B2] inhibits the reaction [Lipopolysaccharides results in increased secretion of IL12B protein] CTD PMID:22445859 NCBI chr10:28,888,832...28,903,796
Ensembl chr10:28,893,008...28,902,903
JBrowse link
G Il1b interleukin 1 beta increases expression ISO aflatoxin G1 results in increased expression of IL1B mRNA CTD PMID:25445582 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 increases expression ISO aflatoxin G1 results in increased expression of IL6 mRNA CTD PMID:25445582 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Mrpl12 mitochondrial ribosomal protein L12 multiple interactions ISO [Aflatoxin B1 co-treated with aflatoxin B2 co-treated with aflatoxin G1 co-treated with aflatoxin G2] results in decreased expression of MRPL12 mRNA; [Plant Extracts co-treated with Aflatoxin B1 co-treated with aflatoxin B2 co-treated with aflatoxin G1 co-treated with aflatoxin G2] results in decreased expression of MRPL12 mRNA CTD PMID:31904472 NCBI chr10:105,758,410...105,762,913
Ensembl chr10:105,758,410...105,762,913
JBrowse link
G Mt-atp8 mitochondrially encoded ATP synthase membrane subunit 8 multiple interactions ISO [Aflatoxin B1 co-treated with aflatoxin B2 co-treated with aflatoxin G1 co-treated with aflatoxin G2] results in decreased expression of ATP8 mRNA; [Plant Extracts co-treated with Aflatoxin B1 co-treated with aflatoxin B2 co-treated with aflatoxin G1 co-treated with aflatoxin G2] results in increased expression of ATP8 mRNA CTD PMID:31904472 NCBI chr MT:7,758...7,961
Ensembl chr MT:7,758...7,961
JBrowse link
G Mt-co1 mitochondrially encoded cytochrome c oxidase I multiple interactions ISO [Aflatoxin B1 co-treated with aflatoxin B2 co-treated with aflatoxin G1 co-treated with aflatoxin G2] results in decreased expression of COX1 mRNA; [Plant Extracts co-treated with Aflatoxin B1 co-treated with aflatoxin B2 co-treated with aflatoxin G1 co-treated with aflatoxin G2] results in decreased expression of COX1 mRNA CTD PMID:31904472 NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867
JBrowse link
G Mt-co3 mitochondrially encoded cytochrome c oxidase III multiple interactions ISO [Plant Extracts co-treated with Aflatoxin B1 co-treated with aflatoxin B2 co-treated with aflatoxin G1 co-treated with aflatoxin G2] results in increased expression of COX3 mRNA CTD PMID:31904472 NCBI chr MT:8,599...9,382
Ensembl chr MT:8,599...9,382
JBrowse link
G Mt-nd3 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 3 multiple interactions ISO [Aflatoxin B1 co-treated with aflatoxin B2 co-treated with aflatoxin G1 co-treated with aflatoxin G2] results in increased expression of ND3 mRNA; [Plant Extracts co-treated with Aflatoxin B1 co-treated with aflatoxin B2 co-treated with aflatoxin G1 co-treated with aflatoxin G2] results in increased expression of ND3 mRNA CTD PMID:31904472 NCBI chr MT:9,451...9,798
Ensembl chr MT:9,451...9,798
JBrowse link
G Mt-nd4 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4 multiple interactions ISO [Aflatoxin B1 co-treated with aflatoxin B2 co-treated with aflatoxin G1 co-treated with aflatoxin G2] results in increased expression of ND4 mRNA; [Plant Extracts co-treated with Aflatoxin B1 co-treated with aflatoxin B2 co-treated with aflatoxin G1 co-treated with aflatoxin G2] results in increased expression of ND4 mRNA CTD PMID:31904472 NCBI chr MT:10,160...11,537
Ensembl chr MT:10,160...11,537
JBrowse link
G Mt-nd4l mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4L multiple interactions ISO [Aflatoxin B1 co-treated with aflatoxin B2 co-treated with aflatoxin G1 co-treated with aflatoxin G2] results in increased expression of ND4L mRNA; [Plant Extracts co-treated with Aflatoxin B1 co-treated with aflatoxin B2 co-treated with aflatoxin G1 co-treated with aflatoxin G2] results in increased expression of ND4L mRNA CTD PMID:31904472 NCBI chr MT:9,870...10,166
Ensembl chr MT:9,870...10,166
JBrowse link
G Mt-nd5 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 5 multiple interactions ISO [Aflatoxin B1 co-treated with aflatoxin B2 co-treated with aflatoxin G1 co-treated with aflatoxin G2] results in decreased expression of ND5 mRNA CTD PMID:31904472 NCBI chr MT:11,736...13,565
Ensembl chr MT:11,736...13,565
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
increases activity
ISO aflatoxin G1 promotes the reaction [NR1I2 protein binds to CYP3A4 promoter]
aflatoxin G1 results in increased activity of NR1I2 protein
CTD PMID:21641981 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Osgin1 oxidative stress induced growth inhibitor 1 multiple interactions ISO [Plant Extracts co-treated with Aflatoxin B1 co-treated with aflatoxin B2 co-treated with aflatoxin G1 co-treated with aflatoxin G2] results in decreased expression of OSGIN1 mRNA CTD PMID:31904472 NCBI chr19:47,471,750...47,500,517
Ensembl chr19:47,492,171...47,500,516
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases expression ISO aflatoxin G1 results in increased expression of PARP1 protein modified form CTD PMID:23907605 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Psmb9 proteasome 20S subunit beta 9 decreases expression ISO aflatoxin G1 results in decreased expression of PSMB9 protein CTD PMID:20381597 NCBI chr20:4,667,044...4,672,512
Ensembl chr20:4,666,046...4,672,512
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO aflatoxin G1 results in increased expression of PTGS2 protein CTD PMID:25445582 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO aflatoxin G1 results in increased expression of and affects the localization of RELA protein CTD PMID:25445582 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Sod2 superoxide dismutase 2 increases expression ISO aflatoxin G1 results in increased expression of SOD2 protein CTD PMID:25445582 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Srxn1 sulfiredoxin 1 multiple interactions ISO [Plant Extracts co-treated with Aflatoxin B1 co-treated with aflatoxin B2 co-treated with aflatoxin G1 co-treated with aflatoxin G2] results in decreased expression of SRXN1 mRNA CTD PMID:31904472 NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448
JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases phosphorylation ISO aflatoxin G1 results in increased phosphorylation of STAT3 protein CTD PMID:25445582 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Tap1 transporter 1, ATP binding cassette subfamily B member decreases expression ISO aflatoxin G1 results in decreased expression of TAP1 mRNA; aflatoxin G1 results in decreased expression of TAP1 protein CTD PMID:20381597 NCBI chr20:4,656,262...4,666,634
Ensembl chr20:4,656,263...4,666,901
JBrowse link
G Tlr2 toll-like receptor 2 multiple interactions ISO aflatoxin G1 inhibits the reaction [Lipopolysaccharides results in increased expression of TLR2 protein] CTD PMID:22445859 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
ISO [aflatoxin G1 co-treated with Aflatoxin B1] inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; aflatoxin G1 inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
aflatoxin G1 results in increased expression of TNF mRNA; aflatoxin G1 results in increased expression of TNF protein
CTD PMID:22445859 PMID:25445582 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tp53 tumor protein p53 increases expression
increases activity
multiple interactions
ISO aflatoxin G1 results in increased expression of TP53 protein modified form
aflatoxin G1 results in increased activity of TP53 protein
Methoxsalen inhibits the reaction [aflatoxin G1 results in increased expression of TP53 protein modified form]; Nicotine inhibits the reaction [aflatoxin G1 results in increased expression of TP53 protein modified form]
CTD PMID:23907605 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Txnip thioredoxin interacting protein multiple interactions ISO [Aflatoxin B1 co-treated with aflatoxin B2 co-treated with aflatoxin G1 co-treated with aflatoxin G2] results in increased expression of TXNIP mRNA CTD PMID:31904472 NCBI chr 2:184,093,079...184,096,882
Ensembl chr 2:184,092,991...184,096,886
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO aflatoxin G1 results in increased expression of VEGFA protein CTD PMID:25445582 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
Aflatoxin G2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mrpl12 mitochondrial ribosomal protein L12 multiple interactions ISO [Aflatoxin B1 co-treated with aflatoxin B2 co-treated with aflatoxin G1 co-treated with aflatoxin G2] results in decreased expression of MRPL12 mRNA; [Plant Extracts co-treated with Aflatoxin B1 co-treated with aflatoxin B2 co-treated with aflatoxin G1 co-treated with aflatoxin G2] results in decreased expression of MRPL12 mRNA CTD PMID:31904472 NCBI chr10:105,758,410...105,762,913
Ensembl chr10:105,758,410...105,762,913
JBrowse link
G Mt-atp8 mitochondrially encoded ATP synthase membrane subunit 8 multiple interactions ISO [Aflatoxin B1 co-treated with aflatoxin B2 co-treated with aflatoxin G1 co-treated with aflatoxin G2] results in decreased expression of ATP8 mRNA; [Plant Extracts co-treated with Aflatoxin B1 co-treated with aflatoxin B2 co-treated with aflatoxin G1 co-treated with aflatoxin G2] results in increased expression of ATP8 mRNA CTD PMID:31904472 NCBI chr MT:7,758...7,961
Ensembl chr MT:7,758...7,961
JBrowse link
G Mt-co1 mitochondrially encoded cytochrome c oxidase I multiple interactions ISO [Aflatoxin B1 co-treated with aflatoxin B2 co-treated with aflatoxin G1 co-treated with aflatoxin G2] results in decreased expression of COX1 mRNA; [Plant Extracts co-treated with Aflatoxin B1 co-treated with aflatoxin B2 co-treated with aflatoxin G1 co-treated with aflatoxin G2] results in decreased expression of COX1 mRNA CTD PMID:31904472 NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867
JBrowse link
G Mt-co3 mitochondrially encoded cytochrome c oxidase III multiple interactions ISO [Plant Extracts co-treated with Aflatoxin B1 co-treated with aflatoxin B2 co-treated with aflatoxin G1 co-treated with aflatoxin G2] results in increased expression of COX3 mRNA CTD PMID:31904472 NCBI chr MT:8,599...9,382
Ensembl chr MT:8,599...9,382
JBrowse link
G Mt-nd3 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 3 multiple interactions ISO [Aflatoxin B1 co-treated with aflatoxin B2 co-treated with aflatoxin G1 co-treated with aflatoxin G2] results in increased expression of ND3 mRNA; [Plant Extracts co-treated with Aflatoxin B1 co-treated with aflatoxin B2 co-treated with aflatoxin G1 co-treated with aflatoxin G2] results in increased expression of ND3 mRNA CTD PMID:31904472 NCBI chr MT:9,451...9,798
Ensembl chr MT:9,451...9,798
JBrowse link
G Mt-nd4 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4 multiple interactions ISO [Aflatoxin B1 co-treated with aflatoxin B2 co-treated with aflatoxin G1 co-treated with aflatoxin G2] results in increased expression of ND4 mRNA; [Plant Extracts co-treated with Aflatoxin B1 co-treated with aflatoxin B2 co-treated with aflatoxin G1 co-treated with aflatoxin G2] results in increased expression of ND4 mRNA CTD PMID:31904472 NCBI chr MT:10,160...11,537
Ensembl chr MT:10,160...11,537
JBrowse link
G Mt-nd4l mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4L multiple interactions ISO [Aflatoxin B1 co-treated with aflatoxin B2 co-treated with aflatoxin G1 co-treated with aflatoxin G2] results in increased expression of ND4L mRNA; [Plant Extracts co-treated with Aflatoxin B1 co-treated with aflatoxin B2 co-treated with aflatoxin G1 co-treated with aflatoxin G2] results in increased expression of ND4L mRNA CTD PMID:31904472 NCBI chr MT:9,870...10,166
Ensembl chr MT:9,870...10,166
JBrowse link
G Mt-nd5 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 5 multiple interactions ISO [Aflatoxin B1 co-treated with aflatoxin B2 co-treated with aflatoxin G1 co-treated with aflatoxin G2] results in decreased expression of ND5 mRNA CTD PMID:31904472 NCBI chr MT:11,736...13,565
Ensembl chr MT:11,736...13,565
JBrowse link
G Osgin1 oxidative stress induced growth inhibitor 1 multiple interactions ISO [Plant Extracts co-treated with Aflatoxin B1 co-treated with aflatoxin B2 co-treated with aflatoxin G1 co-treated with aflatoxin G2] results in decreased expression of OSGIN1 mRNA CTD PMID:31904472 NCBI chr19:47,471,750...47,500,517
Ensembl chr19:47,492,171...47,500,516
JBrowse link
G Srxn1 sulfiredoxin 1 multiple interactions ISO [Plant Extracts co-treated with Aflatoxin B1 co-treated with aflatoxin B2 co-treated with aflatoxin G1 co-treated with aflatoxin G2] results in decreased expression of SRXN1 mRNA CTD PMID:31904472 NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448
JBrowse link
G Txnip thioredoxin interacting protein multiple interactions ISO [Aflatoxin B1 co-treated with aflatoxin B2 co-treated with aflatoxin G1 co-treated with aflatoxin G2] results in increased expression of TXNIP mRNA CTD PMID:31904472 NCBI chr 2:184,093,079...184,096,882
Ensembl chr 2:184,092,991...184,096,886
JBrowse link
anthocyanin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle multiple interactions
decreases expression
ISO
EXP
Anthocyanins inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]
Anthocyanins inhibits the reaction [Paraquat results in increased expression of ACTA2 mRNA]; Anthocyanins inhibits the reaction [Paraquat results in increased expression of ACTA2 protein]
Anthocyanins results in decreased expression of ACTA2 mRNA; Anthocyanins results in decreased expression of ACTA2 protein
CTD PMID:30056145 PMID:30403199 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Ager advanced glycosylation end product-specific receptor multiple interactions ISO Anthocyanins inhibits the reaction [Dietary Fats results in increased expression of AGER protein] CTD PMID:24795233 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078
JBrowse link
G Atm ATM serine/threonine kinase increases phosphorylation ISO Anthocyanins results in increased phosphorylation of ATM protein CTD PMID:27444805 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
JBrowse link
G B2m beta-2 microglobulin multiple interactions EXP Anthocyanins inhibits the reaction [Carbon Tetrachloride results in increased expression of B2M protein] CTD PMID:30825423 NCBI chr 3:109,095,740...109,101,764
Ensembl chr 3:109,095,729...109,101,766
JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions EXP Anthocyanins inhibits the reaction [Streptozocin results in decreased expression of BAD protein modified form]; Anthocyanins inhibits the reaction [Streptozocin results in increased expression of BAD protein] CTD PMID:28856781 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
JBrowse link
G Bak1 BCL2-antagonist/killer 1 multiple interactions EXP Anthocyanins inhibits the reaction [Streptozocin results in increased expression of BAK1 protein] CTD PMID:28856781 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP Anthocyanins inhibits the reaction [Paraquat results in increased expression of BAX mRNA]; Anthocyanins inhibits the reaction [Paraquat results in increased expression of BAX protein] CTD PMID:30403199 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP Anthocyanins inhibits the reaction [Paraquat results in decreased expression of BCL2 mRNA]; Anthocyanins inhibits the reaction [Paraquat results in decreased expression of BCL2 protein]; Anthocyanins inhibits the reaction [Streptozocin results in decreased expression of BCL2 protein] CTD PMID:28856781 PMID:30403199 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions EXP Anthocyanins inhibits the reaction [Streptozocin results in decreased expression of BCL2L1 protein] CTD PMID:28856781 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Car1 carbonic anhydrase 1 decreases activity ISO Anthocyanins results in decreased activity of CA1 protein CTD PMID:28445001 NCBI chr 2:86,829,436...86,872,209
Ensembl chr 2:86,861,897...86,872,208
JBrowse link
G Car2 carbonic anhydrase 2 decreases activity ISO Anthocyanins results in decreased activity of CA2 protein CTD PMID:28445001 NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818
JBrowse link
G Casp1 caspase 1 multiple interactions ISO Anthocyanins inhibits the reaction [Dietary Fats results in increased activity of CASP1 protein] CTD PMID:24795233 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
JBrowse link
G Casp3 caspase 3 multiple interactions EXP Anthocyanins inhibits the reaction [Streptozocin results in increased cleavage of CASP3 protein] CTD PMID:28856781 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 multiple interactions EXP Anthocyanins inhibits the reaction [Streptozocin results in increased expression of CASP8 protein] CTD PMID:28856781 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 multiple interactions EXP Anthocyanins inhibits the reaction [Streptozocin results in increased expression of CASP9 protein] CTD PMID:28856781 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cat catalase multiple interactions EXP Anthocyanins inhibits the reaction [Carbon Tetrachloride results in decreased activity of CAT protein] CTD PMID:30825423 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Anthocyanins inhibits the reaction [Carbon Tetrachloride results in increased expression of CCL2 protein] CTD PMID:30056145 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccn2 cellular communication network factor 2 decreases expression ISO Anthocyanins results in decreased expression of CCN2 mRNA CTD PMID:30056145 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
JBrowse link
G Ccnb1 cyclin B1 increases expression
multiple interactions
ISO Anthocyanins results in increased expression of CCNB1 protein
Anthocyanins promotes the reaction [CDK1 protein binds to CCNB1 protein]
CTD PMID:27444805 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Cdc25c cell division cycle 25C multiple interactions
increases phosphorylation
ISO Anthocyanins results in decreased expression of and results in increased phosphorylation of CDC25C protein
Anthocyanins results in increased phosphorylation of CDC25C protein
CTD PMID:27444805 NCBI chr18:26,335,156...26,356,199
Ensembl chr18:26,335,834...26,356,185
JBrowse link
G Cdh1 cadherin 1 multiple interactions EXP Anthocyanins inhibits the reaction [Paraquat results in decreased expression of CDH1 protein] CTD PMID:30403199 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Cdk1 cyclin-dependent kinase 1 multiple interactions ISO Anthocyanins promotes the reaction [CDK1 protein binds to CCNB1 protein]; Anthocyanins results in increased expression of and results in increased phosphorylation of CDK1 protein CTD PMID:27444805 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO Anthocyanins results in increased expression of CDKN1A protein CTD PMID:27444805 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO Anthocyanins results in increased expression of CDKN1B protein CTD PMID:27444805 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
JBrowse link
G Chek1 checkpoint kinase 1 increases phosphorylation ISO Anthocyanins results in increased phosphorylation of CHEK1 protein CTD PMID:27444805 NCBI chr 8:36,420,565...36,443,477 JBrowse link
G Chek2 checkpoint kinase 2 increases phosphorylation ISO Anthocyanins results in increased phosphorylation of CHEK2 protein CTD PMID:27444805 NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286
JBrowse link
G Cldn4 claudin 4 multiple interactions EXP Anthocyanins inhibits the reaction [Cyclophosphamide results in decreased expression of CLDN4 protein] CTD PMID:25451569 NCBI chr12:21,751,638...21,753,436
Ensembl chr12:21,751,331...21,753,436
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions EXP Anthocyanins inhibits the reaction [Paraquat results in increased expression of COL1A1 mRNA] CTD PMID:30403199 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
JBrowse link
G Col3a1 collagen type III alpha 1 chain multiple interactions ISO Anthocyanins inhibits the reaction [Carbon Tetrachloride results in increased expression of COL3A1 protein] CTD PMID:30056145 NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547
JBrowse link
G Ctsd cathepsin D multiple interactions EXP Anthocyanins inhibits the reaction [Cyclophosphamide results in increased activity of CTSD protein] CTD PMID:25451569 NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions ISO Anthocyanins inhibits the reaction [Carbon Tetrachloride results in increased expression of CXCL2] CTD PMID:30056145 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 increases expression EXP Anthocyanins results in increased expression of CYP2C mRNA CTD PMID:18803703 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases expression EXP Anthocyanins results in increased expression of CYP2E1 mRNA CTD PMID:18803703 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression EXP Anthocyanins results in increased expression of CYP3A2 mRNA CTD PMID:18803703 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases expression EXP Anthocyanins results in increased expression of CYP3A23-3A1 mRNA CTD PMID:18803703 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
JBrowse link
G Fadd Fas associated via death domain multiple interactions EXP Anthocyanins inhibits the reaction [Streptozocin results in increased expression of FADD protein] CTD PMID:28856781 NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653
JBrowse link
G Fas Fas cell surface death receptor multiple interactions EXP Anthocyanins inhibits the reaction [Streptozocin results in increased expression of FAS protein] CTD PMID:28856781 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Faslg Fas ligand multiple interactions EXP Anthocyanins inhibits the reaction [Streptozocin results in increased expression of FASLG protein] CTD PMID:28856781 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP Anthocyanins inhibits the reaction [Carbon Tetrachloride results in decreased activity of GSR protein] CTD PMID:30825423 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Gusb glucuronidase, beta multiple interactions EXP Anthocyanins inhibits the reaction [Cyclophosphamide results in increased activity of GUSB protein] CTD PMID:25451569 NCBI chr12:26,701,191...26,714,718
Ensembl chr12:26,697,951...26,726,905
JBrowse link
G H2ax H2A.X variant histone increases phosphorylation ISO Anthocyanins results in increased phosphorylation of H2AX protein CTD PMID:27444805 NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239
JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 multiple interactions EXP Anthocyanins inhibits the reaction [Carbon Tetrachloride results in increased expression of HAVCR1 protein] CTD PMID:30825423 NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions ISO Anthocyanins inhibits the reaction [Dietary Fats results in increased phosphorylation of IKBKB protein] CTD PMID:24795233 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250
JBrowse link
G Il10 interleukin 10 multiple interactions EXP Anthocyanins inhibits the reaction [Cyclophosphamide results in decreased expression of IL10 protein] CTD PMID:25451569 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP
ISO
Anthocyanins inhibits the reaction [Cyclophosphamide results in increased expression of IL1B protein]
Anthocyanins inhibits the reaction [Carbon Tetrachloride results in increased expression of IL1B protein]; Anthocyanins inhibits the reaction [Dietary Fats results in increased expression of IL1B protein]
CTD PMID:24795233 PMID:25451569 PMID:30056145 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Lcn2 lipocalin 2 multiple interactions EXP Anthocyanins inhibits the reaction [Carbon Tetrachloride results in increased expression of LCN2 protein] CTD PMID:30825423 NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO Anthocyanins inhibits the reaction [Carbon Tetrachloride results in decreased expression of MMP9 protein] CTD PMID:30056145 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mpo myeloperoxidase multiple interactions EXP Anthocyanins inhibits the reaction [Carbon Tetrachloride results in increased activity of MPO protein]; Anthocyanins inhibits the reaction [Cyclophosphamide results in increased activity of MPO protein] CTD PMID:25451569 PMID:30825423 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO Anthocyanins inhibits the reaction [Dietary Fats results in increased degradation of NFKBIA protein] CTD PMID:24795233 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO Anthocyanins inhibits the reaction [Dietary Fats results in increased expression of NLRP3 protein] CTD PMID:24795233 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Anthocyanins inhibits the reaction [Dietary Fats results in increased expression of NOS2 protein] CTD PMID:24795233 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions EXP Anthocyanins inhibits the reaction [Streptozocin results in increased cleavage of PARP1 protein] CTD PMID:28856781 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO Anthocyanins inhibits the reaction [Carbon Tetrachloride results in increased expression of PCNA protein] CTD PMID:30056145 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Pde5a phosphodiesterase 5A decreases activity ISO Anthocyanins results in decreased activity of PDE5A protein CTD PMID:15769121 NCBI chr 2:210,858,515...211,003,480
Ensembl chr 2:210,858,063...210,999,701
JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 increases expression EXP Anthocyanins results in increased expression of PIK3R1 mRNA CTD PMID:18803703 NCBI chr 2:32,878,942...32,963,611
Ensembl chr 2:32,882,032...32,963,631
JBrowse link
G Pla2g2a phospholipase A2 group IIA increases expression EXP Anthocyanins results in increased expression of PLA2G2A mRNA CTD PMID:18803703 NCBI chr 5:151,076,442...151,079,019
Ensembl chr 5:151,076,442...151,079,014
JBrowse link
G Plcd4 phospholipase C, delta 4 increases expression EXP Anthocyanins results in increased expression of PLCD4 mRNA CTD PMID:18803703 NCBI chr 9:76,115,523...76,158,602
Ensembl chr 9:76,117,168...76,142,453
JBrowse link
G Por cytochrome p450 oxidoreductase increases expression EXP Anthocyanins results in increased expression of POR mRNA CTD PMID:18803703 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Anthocyanins inhibits the reaction [Dietary Fats results in increased expression of PTGS2 protein] CTD PMID:24795233 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Pycard PYD and CARD domain containing multiple interactions ISO Anthocyanins inhibits the reaction [Dietary Fats results in increased expression of PYCARD protein] CTD PMID:24795233 NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP Anthocyanins inhibits the reaction [Cyclophosphamide results in increased activity of RELA protein] CTD PMID:25451569 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Smad2 SMAD family member 2 multiple interactions EXP Anthocyanins inhibits the reaction [Paraquat results in increased phosphorylation of SMAD2 protein] CTD PMID:30403199 NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323
JBrowse link
G Snca synuclein alpha decreases expression ISO Anthocyanins results in decreased expression of SNCA protein CTD PMID:29976995 NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262
JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression
multiple interactions
ISO
EXP
Anthocyanins results in decreased expression of TGFB1 mRNA
Anthocyanins inhibits the reaction [Paraquat results in increased expression of TGFB1 protein]
CTD PMID:30056145 PMID:30403199 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 multiple interactions EXP Anthocyanins inhibits the reaction [Paraquat results in increased expression of TGFBR1 protein] CTD PMID:30403199 NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions ISO Anthocyanins inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP1 protein] CTD PMID:30056145 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664
JBrowse link
G Tjp1 tight junction protein 1 multiple interactions EXP Anthocyanins inhibits the reaction [Cyclophosphamide results in decreased expression of TJP1 protein] CTD PMID:25451569 NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP
ISO
Anthocyanins inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]; Anthocyanins inhibits the reaction [Cyclophosphamide results in increased expression of TNF protein]
Anthocyanins inhibits the reaction [Lipopolysaccharides results in increased expression of TNF]
CTD PMID:18720166 PMID:25451569 PMID:30825423 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Txnip thioredoxin interacting protein multiple interactions ISO Anthocyanins inhibits the reaction [Dietary Fats results in increased expression of TXNIP protein] CTD PMID:24795233 NCBI chr 2:184,093,079...184,096,882
Ensembl chr 2:184,092,991...184,096,886
JBrowse link
G Vim vimentin multiple interactions EXP Anthocyanins inhibits the reaction [Paraquat results in increased expression of VIM mRNA]; Anthocyanins inhibits the reaction [Paraquat results in increased expression of VIM protein] CTD PMID:30403199 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
JBrowse link
G Xdh xanthine dehydrogenase multiple interactions EXP Anthocyanins inhibits the reaction [Carbon Tetrachloride results in increased activity of XDH protein] CTD PMID:30825423 NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268
JBrowse link
auraptene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO aurapten promotes the reaction [ABCB1 protein results in increased hydrolysis of Adenosine Triphosphate]; aurapten promotes the reaction [ABCB1 protein results in increased import of Daunorubicin] CTD PMID:18955043 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Ccna2 cyclin A2 affects expression ISO aurapten affects the expression of CCNA2 mRNA CTD PMID:23320178 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
JBrowse link
G Ccnb2 cyclin B2 affects expression ISO aurapten affects the expression of CCNB2 mRNA CTD PMID:23320178 NCBI chr 8:71,087,594...71,100,794
Ensembl chr 8:71,087,595...71,100,874
JBrowse link
G Cdc45 cell division cycle 45 affects expression ISO aurapten affects the expression of CDC45 mRNA CTD PMID:23320178 NCBI chr11:82,185,427...82,210,630
Ensembl chr11:82,185,473...82,210,619
JBrowse link
G Cdk1 cyclin-dependent kinase 1 affects expression ISO aurapten affects the expression of CDK1 mRNA CTD PMID:23320178 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
JBrowse link
G Cdkn2b cyclin-dependent kinase inhibitor 2B affects expression ISO aurapten affects the expression of CDKN2B mRNA CTD PMID:23320178 NCBI chr 5:104,009,839...104,019,082
Ensembl chr 5:104,010,680...104,019,050
JBrowse link
G Cdkn2c cyclin-dependent kinase inhibitor 2C affects expression ISO aurapten affects the expression of CDKN2C mRNA CTD PMID:23320178 NCBI chr 5:124,411,123...124,416,278
Ensembl chr 5:124,411,124...124,416,278
JBrowse link
G Chek1 checkpoint kinase 1 affects expression ISO aurapten affects the expression of CHEK1 mRNA CTD PMID:23320178 NCBI chr 8:36,420,565...36,443,477 JBrowse link
G Chek2 checkpoint kinase 2 affects expression ISO aurapten affects the expression of CHEK2 mRNA CTD PMID:23320178 NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286
JBrowse link
G Ctnnb1 catenin beta 1 decreases expression EXP aurapten results in decreased expression of CTNNB1 protein mutant form CTD PMID:16012713 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO aurapten inhibits the reaction [DDT results in increased expression of CYP1A1 mRNA]; aurapten inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] CTD PMID:20865247 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 affects expression ISO aurapten affects the expression of DDIT3 mRNA CTD PMID:23320178 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Dusp1 dual specificity phosphatase 1 affects expression ISO aurapten affects the expression of DUSP1 mRNA CTD PMID:23320178 NCBI chr10:16,680,489...16,683,276 JBrowse link
G E2f1 E2F transcription factor 1 affects expression ISO aurapten affects the expression of E2F1 mRNA CTD PMID:23320178 NCBI chr 3:143,064,535...143,075,362 JBrowse link
G E2f2 E2F transcription factor 2 affects expression ISO aurapten affects the expression of E2F2 mRNA CTD PMID:23320178 NCBI chr 5:148,399,193...148,422,595
Ensembl chr 5:148,399,642...148,421,217
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha affects expression ISO aurapten affects the expression of GADD45A mRNA CTD PMID:23320178 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit affects expression ISO aurapten affects the expression of JUN mRNA CTD PMID:23320178 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Kif20b kinesin family member 20B affects expression ISO aurapten affects the expression of KIF20B mRNA CTD PMID:23320178 NCBI chr 1:232,428,293...232,483,798
Ensembl chr 1:232,428,371...232,483,787
JBrowse link
G Mcm3 minichromosome maintenance complex component 3 affects expression ISO aurapten affects the expression of MCM3 mRNA CTD PMID:23320178 NCBI chr 9:23,219,169...23,237,314
Ensembl chr 9:23,219,169...23,237,314
JBrowse link
G Mcm6 minichromosome maintenance complex component 6 affects expression ISO aurapten affects the expression of MCM6 mRNA CTD PMID:23320178 NCBI chr13:39,826,745...39,851,937
Ensembl chr13:39,826,763...39,851,960
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 affects response to substance ISO NFE2L2 protein affects the susceptibility to aurapten CTD PMID:19150646 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO aurapten inhibits the reaction [DDT results in increased expression of PTGS2 mRNA]; aurapten inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PTGS2 mRNA] CTD PMID:20865247 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Uhrf1 ubiquitin-like with PHD and ring finger domains 1 affects expression ISO aurapten affects the expression of UHRF1 mRNA CTD PMID:23320178 NCBI chr 9:1,133,117...1,154,639
Ensembl chr 9:1,134,909...1,154,631
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO aurapten inhibits the reaction [DDT results in increased expression of VEGFA mRNA]; aurapten inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of VEGFA mRNA] CTD PMID:20865247 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
Biflorin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Braf B-Raf proto-oncogene, serine/threonine kinase affects expression ISO biflorin affects the expression of BRAF mRNA CTD PMID:27079618 NCBI chr 4:68,375,484...68,510,652
Ensembl chr 4:68,384,649...68,510,463
JBrowse link
G Melk maternal embryonic leucine zipper kinase affects expression ISO biflorin affects the expression of MELK mRNA CTD PMID:27079618 NCBI chr 5:58,540,393...58,600,937
Ensembl chr 5:58,540,449...58,600,937
JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase affects expression ISO biflorin affects the expression of MGMT mRNA CTD PMID:27079618 NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756
JBrowse link
G Rad54l RAD54 like affects expression ISO biflorin affects the expression of RAD54L mRNA CTD PMID:27079618 NCBI chr 5:129,575,431...129,605,100
Ensembl chr 5:129,575,378...129,605,070
JBrowse link
G Tyms thymidylate synthetase affects expression ISO biflorin affects the expression of TYMS mRNA CTD PMID:27079618 NCBI chr 9:113,313,454...113,329,551
Ensembl chr 9:113,313,452...113,329,536
JBrowse link
chromone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions
increases expression
ISO benzyloxycarbonyl-valyl-alanyl-aspartyl-fluoromethane inhibits the reaction [4-chromone analog results in increased expression of CASP3 protein modified form] CTD PMID:30256521 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 multiple interactions
increases expression
ISO benzyloxycarbonyl-valyl-alanyl-aspartyl-fluoromethane inhibits the reaction [4-chromone analog results in increased expression of CASP8 protein modified form] CTD PMID:30256521 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 multiple interactions
increases expression
ISO benzyloxycarbonyl-valyl-alanyl-aspartyl-fluoromethane inhibits the reaction [4-chromone analog results in increased expression of CASP9 protein modified form] CTD PMID:30256521 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G H2ax H2A.X variant histone increases expression ISO 4-chromone analog results in increased expression of H2AX protein modified form CTD PMID:30256521 NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases expression
multiple interactions
ISO 4-chromone analog results in increased expression of PARP1 protein modified form
Acetylcysteine inhibits the reaction [4-chromone analog results in increased expression of PARP1 protein modified form]; benzyloxycarbonyl-valyl-alanyl-aspartyl-fluoromethane inhibits the reaction [4-chromone analog results in increased expression of PARP1 protein modified form]
CTD PMID:30256521 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
chromones term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 affects binding
multiple interactions
ISO [Chromones analog binds to cuprous chloride] which binds to AKT1 protein
[Chromones analog binds to cuprous chloride] which results in decreased activity of AKT1 protein
CTD PMID:16789737 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Calr calreticulin increases activity ISO Chromones results in increased activity of CALR protein CTD PMID:20188080 NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions
increases expression
ISO N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [Chromones analog results in increased expression of MAPK9 protein modified form] CTD PMID:22583868 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
JBrowse link
cloricromen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Icam1 intercellular adhesion molecule 1 multiple interactions EXP cloricromen inhibits the reaction [Streptozocin results in increased expression of ICAM1 protein] CTD PMID:19279317 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP cloricromen inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA] CTD PMID:15322736 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions EXP cloricromen inhibits the reaction [Streptozocin results in increased expression of NOS3 protein] CTD PMID:19279317 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression
EXP cloricromen inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; cloricromen inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; cloricromen inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; cloricromen inhibits the reaction [Streptozocin results in increased expression of TNF protein]
cloricromen results in decreased expression of TNF protein
CTD PMID:11343695 PMID:15322736 PMID:16572308 PMID:19279317 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions EXP cloricromen inhibits the reaction [Streptozocin results in increased expression of VEGFA protein] CTD PMID:19279317 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
Coumachlor term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Vkorc1 vitamin K epoxide reductase complex, subunit 1 multiple interactions
decreases activity
ISO coumachlor inhibits the reaction [VKORC1 protein results in increased reduction of Vitamin K 1]; coumachlor inhibits the reaction [VKORC1 protein results in increased reduction of vitamin K1 oxide]
coumachlor results in decreased activity of VKORC1 protein
CTD PMID:29581108 NCBI chr 1:182,502,491...182,505,012
Ensembl chr 1:182,500,844...182,505,008
JBrowse link
G Vkorc1l1 vitamin K epoxide reductase complex, subunit 1-like 1 decreases activity
multiple interactions
ISO coumachlor results in decreased activity of VKORC1L1 protein
coumachlor inhibits the reaction [VKORC1L1 protein results in increased reduction of Vitamin K 1]; coumachlor inhibits the reaction [VKORC1L1 protein results in increased reduction of vitamin K1 oxide]
CTD PMID:29581108 NCBI chr12:26,717,959...26,768,193 JBrowse link
coumaphos term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity ISO Coumaphos metabolite results in decreased activity of ACHE protein; Coumaphos results in decreased activity of ACHE protein CTD PMID:30625376 PMID:33844597 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Ar androgen receptor multiple interactions ISO Coumaphos inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein] CTD PMID:33049310 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Coumaphos binds to and results in increased activity of ESR1 protein CTD PMID:33049310 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO Coumaphos binds to and results in increased activity of ESR2 protein CTD PMID:33049310 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
JBrowse link
G Gpat3 glycerol-3-phosphate acyltransferase 3 increases expression ISO Coumaphos results in increased expression of GPAT3 mRNA CTD PMID:26198647 NCBI chr14:8,715,367...8,768,051
Ensembl chr14:8,714,373...8,766,490
JBrowse link
G Lif LIF, interleukin 6 family cytokine increases expression ISO Coumaphos results in increased expression of LIF mRNA CTD PMID:26198647 NCBI chr14:79,131,049...79,140,486
Ensembl chr14:79,134,574...79,140,482
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO Coumaphos binds to and results in increased activity of NR1I2 protein CTD PMID:33049310 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO Coumaphos binds to and results in increased activity of PPARG protein CTD PMID:33049310 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Rara retinoic acid receptor, alpha increases activity ISO Coumaphos results in increased activity of RARA protein CTD PMID:20143881 NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142
JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO Coumaphos results in increased expression of SLC7A11 mRNA CTD PMID:26198647 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
JBrowse link
G Thrb thyroid hormone receptor beta multiple interactions ISO Coumaphos binds to and results in increased activity of THRB protein CTD PMID:33049310 NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916
JBrowse link
coumarin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aass aminoadipate-semialdehyde synthase decreases expression EXP coumarin results in decreased expression of AASS mRNA CTD PMID:18480146 NCBI chr 4:51,606,461...51,663,136
Ensembl chr 4:51,606,462...51,663,136
JBrowse link
G Abcb11 ATP binding cassette subfamily B member 11 affects expression EXP coumarin affects the expression of ABCB11 mRNA CTD PMID:16963487 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression EXP coumarin results in increased expression of ABCC3 mRNA CTD PMID:18480146 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
JBrowse link
G Acaa1a acetyl-CoA acyltransferase 1A increases expression EXP coumarin results in increased expression of ACAA1 mRNA CTD PMID:18480146 NCBI chr 8:119,079,401...119,088,624
Ensembl chr 8:119,079,775...119,088,624
JBrowse link
G Acaa2 acetyl-CoA acyltransferase 2 affects expression EXP coumarin affects the expression of ACAA2 mRNA CTD PMID:16963487 NCBI chr18:68,345,136...68,373,246
Ensembl chr18:68,345,012...68,373,249
JBrowse link
G Ache acetylcholinesterase multiple interactions ISO coumarin inhibits the reaction [Dichlorvos results in increased phosphorylation of ACHE protein]; coumarin inhibits the reaction [haloxon results in increased phosphorylation of ACHE protein]; coumarin inhibits the reaction [Paraoxon results in increased phosphorylation of ACHE protein] CTD PMID:10421444 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Acly ATP citrate lyase affects expression EXP coumarin affects the expression of ACLY mRNA CTD PMID:16963487 NCBI chr10:85,412,045...85,464,253
Ensembl chr10:85,412,049...85,463,320
JBrowse link
G Aco1 aconitase 1 affects expression EXP coumarin affects the expression of ACO1 mRNA CTD PMID:16963487 NCBI chr 5:55,259,841...55,315,872
Ensembl chr 5:55,259,827...55,316,391
JBrowse link
G Acot4 acyl-CoA thioesterase 4 increases expression EXP coumarin results in increased expression of ACOT4 mRNA CTD PMID:18480146 NCBI chr 6:103,668,699...103,674,037
Ensembl chr 6:103,668,753...103,673,917
JBrowse link
G Acsm1 acyl-CoA synthetase medium-chain family member 1 increases expression ISO coumarin results in increased expression of ACSM1 mRNA CTD PMID:17311802 NCBI chr 1:173,985,715...174,020,565
Ensembl chr 1:173,984,672...174,025,495
JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 decreases expression ISO coumarin analog results in decreased expression of AIFM1 mRNA CTD PMID:32578917 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256
JBrowse link
G Akr1b8 aldo-keto reductase family 1, member B8 increases expression EXP coumarin results in increased expression of AKR1B8 mRNA CTD PMID:18480146 NCBI chr 4:62,997,241...63,009,815 JBrowse link
G Akr1c1 aldo-keto reductase family 1, member C1 decreases expression EXP coumarin results in decreased expression of AKR1C6 mRNA CTD PMID:18480146 NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326
JBrowse link
G Akr1d1 aldo-keto reductase family 1, member D1 affects expression EXP coumarin affects the expression of AKR1D1 mRNA CTD PMID:16963487 NCBI chr 4:66,154,246...66,187,505
Ensembl chr 4:66,154,248...66,186,372
JBrowse link
G Akr7a3 aldo-keto reductase family 7 member A3 increases expression EXP coumarin results in increased expression of AKR7A3 mRNA CTD PMID:18480146 NCBI chr 5:151,590,968...151,601,394
Ensembl chr 5:151,584,479...151,601,394
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO coumarin analog results in decreased expression of and results in decreased phosphorylation of AKT1 protein CTD PMID:32578917 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 increases expression EXP coumarin results in increased expression of ALDH1A1 mRNA CTD PMID:18480146 NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
JBrowse link
G Alox5 arachidonate 5-lipoxygenase increases expression EXP coumarin results in increased expression of ALOX5 mRNA CTD PMID:18480146 NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743
JBrowse link
G Anxa7 annexin A7 increases expression EXP coumarin results in increased expression of ANXA7 mRNA CTD PMID:18480146 NCBI chr15:3,821,798...3,849,659
Ensembl chr15:3,821,845...3,849,385
JBrowse link
G Apbb3 amyloid beta precursor protein binding family B member 3 decreases expression EXP coumarin results in decreased expression of APBB3 mRNA CTD PMID:18480146 NCBI chr18:28,273,168...28,280,347
Ensembl chr18:28,270,545...28,280,094
JBrowse link
G Apcs amyloid P component, serum decreases expression EXP coumarin results in decreased expression of APCS mRNA CTD PMID:18480146 NCBI chr13:85,373,338...85,374,134
Ensembl chr13:85,373,220...85,374,298
JBrowse link
G Arg1 arginase 1 affects expression EXP coumarin affects the expression of ARG1 mRNA CTD PMID:16963487 NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422
JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) increases expression EXP coumarin results in increased expression of ASNS mRNA CTD PMID:18480146 NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423
JBrowse link
G Atp5if1 ATP synthase inhibitory factor subunit 1 increases expression EXP coumarin results in increased expression of ATPIF1 mRNA CTD PMID:18480146 NCBI chr 5:144,738,950...144,742,668
Ensembl chr 5:144,738,950...144,742,668
JBrowse link
G Atrn attractin decreases expression EXP coumarin results in decreased expression of ATRN mRNA CTD PMID:18480146 NCBI chr 3:118,110,320...118,244,326
Ensembl chr 3:118,110,229...118,244,322
JBrowse link
G Avpr1a arginine vasopressin receptor 1A decreases expression EXP coumarin results in decreased expression of AVPR1A mRNA CTD PMID:18480146 NCBI chr 7:58,114,306...58,118,230
Ensembl chr 7:58,114,284...58,122,215
JBrowse link
G Azgp1 alpha-2-glycoprotein 1, zinc-binding affects expression EXP coumarin affects the expression of AZGP1 mRNA CTD PMID:16963487 NCBI chr12:16,930,990...16,939,333
Ensembl chr12:16,931,024...16,939,091
JBrowse link
G Bad BCL2-associated agonist of cell death increases expression ISO coumarin analog results in increased expression of BAD mRNA CTD PMID:32578917 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases expression ISO coumarin analog results in increased expression of BAK1 protein CTD PMID:31199928 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO coumarin analog results in increased expression of BAX mRNA; coumarin results in increased expression of BAX protein CTD PMID:15964220 PMID:32578917 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bbc3 Bcl-2 binding component 3 increases expression ISO coumarin analog results in increased expression of BBC3 protein CTD PMID:31199928 NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509
JBrowse link
G Bbox1 gamma-butyrobetaine hydroxylase 1 decreases expression EXP coumarin results in decreased expression of BBOX1 mRNA CTD PMID:18480146 NCBI chr 3:96,822,654...96,871,786
Ensembl chr 3:96,822,655...96,871,458
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO coumarin analog results in decreased expression of BCL2 mRNA; coumarin results in decreased expression of BCL2 protein CTD PMID:15964220 PMID:32578917 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bhlha15 basic helix-loop-helix family, member a15 increases expression EXP coumarin results in increased expression of BHLHA15 mRNA CTD PMID:18480146 NCBI chr12:10,420,465...10,424,641
Ensembl chr12:10,420,467...10,424,713
JBrowse link
G Bhmt betaine-homocysteine S-methyltransferase decreases expression
affects expression
EXP coumarin results in decreased expression of BHMT mRNA
coumarin affects the expression of BHMT mRNA
CTD PMID:16963487 PMID:18480146 NCBI chr 2:24,859,871...24,879,449
Ensembl chr 2:24,859,873...24,879,742
JBrowse link
G Bid BH3 interacting domain death agonist increases expression ISO coumarin analog results in increased expression of BID mRNA CTD PMID:32578917 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO coumarin analog results in decreased expression of BIRC5 mRNA CTD PMID:32578917 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
JBrowse link
G Ca3 carbonic anhydrase 3 decreases expression EXP coumarin results in decreased expression of CA3 mRNA CTD PMID:18480146 NCBI chr 2:86,770,418...86,780,011
Ensembl chr 2:86,770,420...86,784,280
JBrowse link
G Capn1 calpain 1 decreases expression ISO coumarin analog results in decreased expression of CAPN1 mRNA CTD PMID:32578917 NCBI chr 1:203,275,912...203,300,848
Ensembl chr 1:203,277,344...203,300,177
JBrowse link
G Car1 carbonic anhydrase 1 decreases activity ISO coumarin results in decreased activity of CA1 protein CTD PMID:22077347 NCBI chr 2:86,829,436...86,872,209
Ensembl chr 2:86,861,897...86,872,208
JBrowse link
G Car2 carbonic anhydrase 2 increases expression
decreases activity
EXP
ISO
coumarin results in increased expression of CA2 mRNA
coumarin results in decreased activity of CA2 protein
CTD PMID:18480146 PMID:22077347 NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818
JBrowse link
G Casp3 caspase 3 increases cleavage
increases expression
ISO coumarin analog results in increased cleavage of CASP3 protein
coumarin analog results in increased expression of CASP3 mRNA
CTD PMID:32578917 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 increases expression ISO coumarin analog results in increased expression of CASP8 mRNA CTD PMID:32578917 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 increases expression ISO coumarin analog results in increased expression of CASP9 mRNA CTD PMID:32578917 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cat catalase multiple interactions
decreases activity
EXP
ISO
coumarin inhibits the reaction [[Niacinamide co-treated with Streptozocin] results in decreased activity of CAT protein]
coumarin analog results in decreased activity of CAT protein
CTD PMID:21630391 PMID:32578917 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cbr1 carbonyl reductase 1 increases expression EXP coumarin results in increased expression of CBR1 mRNA CTD PMID:18480146 NCBI chr11:32,860,618...32,862,981
Ensembl chr11:32,908,950...32,911,393
JBrowse link
G Ccnb2 cyclin B2 decreases expression EXP coumarin results in decreased expression of CCNB2 mRNA CTD PMID:18480146 NCBI chr 8:71,087,594...71,100,794
Ensembl chr 8:71,087,595...71,100,874
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO coumarin analog results in decreased expression of CCND1 mRNA CTD PMID:32578917 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Ccne1 cyclin E1 increases expression
decreases expression
EXP
ISO
coumarin results in increased expression of CCNE1 mRNA
coumarin analog results in decreased expression of CCNE1 mRNA
CTD PMID:18480146 PMID:32578917 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
JBrowse link
G Ccne2 cyclin E2 increases expression EXP coumarin results in increased expression of CCNE2 mRNA CTD PMID:18480146 NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632
JBrowse link
G Cdh1 cadherin 1 increases expression ISO coumarin analog results in increased expression of CDH1 mRNA; coumarin analog results in increased expression of CDH1 protein CTD PMID:32578917 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Cdh2 cadherin 2 decreases expression ISO coumarin analog results in decreased expression of CDH2 mRNA CTD PMID:32578917 NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167
JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO coumarin analog results in decreased expression of CDK2 mRNA CTD PMID:32578917 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO coumarin analog results in decreased expression of CDK4 mRNA CTD PMID:32578917 NCBI chr 7:62,885,647...62,889,562
Ensembl chr 7:62,883,105...62,942,403
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO coumarin analog results in increased expression of CDKN1A mRNA CTD PMID:32578917 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cdkn3 cyclin-dependent kinase inhibitor 3 decreases expression EXP coumarin results in decreased expression of CDKN3 mRNA CTD PMID:18480146 NCBI chr15:20,022,522...20,033,948
Ensembl chr15:20,022,664...20,033,945
JBrowse link
G Cdo1 cysteine dioxygenase type 1 affects expression EXP coumarin affects the expression of CDO1 mRNA CTD PMID:16963487 NCBI chr18:39,432,473...39,447,253
Ensembl chr18:39,432,474...39,447,296
JBrowse link
G Ces1d carboxylesterase 1D increases expression ISO coumarin results in increased expression of CES1 mRNA CTD PMID:17311802 NCBI chr19:13,873,490...13,912,035 JBrowse link
G Cisd3 CDGSH iron sulfur domain 3 increases expression EXP coumarin results in increased expression of CISD3 mRNA CTD PMID:18480146 NCBI chr10:82,679,345...82,682,376
Ensembl chr10:82,679,196...82,682,550
JBrowse link
G Cldn3 claudin 3 decreases expression ISO coumarin analog results in decreased expression of CLDN3 mRNA CTD PMID:32578917 NCBI chr12:21,708,538...21,710,010
Ensembl chr12:21,708,398...21,711,001
JBrowse link
G Cldn4 claudin 4 decreases expression ISO coumarin analog results in decreased expression of CLDN4 mRNA CTD PMID:32578917 NCBI chr12:21,751,638...21,753,436
Ensembl chr12:21,751,331...21,753,436
JBrowse link
G Coq6 coenzyme Q6 monooxygenase increases expression EXP coumarin results in increased expression of COQ6 mRNA CTD PMID:18480146 NCBI chr 6:104,007,814...104,019,888
Ensembl chr 6:104,007,872...104,024,657
JBrowse link
G Creg1 cellular repressor of E1A-stimulated genes 1 increases expression EXP coumarin results in increased expression of CREG mRNA CTD PMID:18480146 NCBI chr13:78,019,814...78,032,310
Ensembl chr13:78,019,843...78,032,308
JBrowse link
G Creld2 cysteine-rich with EGF-like domains 2 increases expression EXP coumarin results in increased expression of CRELD2 mRNA CTD PMID:18480146 NCBI chr 7:119,909,626...119,916,556
Ensembl chr 7:119,909,633...119,916,543
JBrowse link
G Cryab crystallin, alpha B decreases expression EXP coumarin results in decreased expression of CRYAB mRNA CTD PMID:18480146 NCBI chr 8:51,093,441...51,099,161
Ensembl chr 8:51,093,441...51,099,157
JBrowse link
G Cryl1 crystallin, lambda 1 increases expression EXP coumarin results in increased expression of CRYL1 mRNA CTD PMID:18480146 NCBI chr15:31,427,011...31,545,997
Ensembl chr15:31,427,054...31,545,997
JBrowse link
G Csad cysteine sulfinic acid decarboxylase decreases expression EXP coumarin results in decreased expression of CSAD mRNA CTD PMID:18480146 NCBI chr 7:133,308,571...133,337,914
Ensembl chr 7:133,308,574...133,337,615
JBrowse link
G Csrp1 cysteine and glycine-rich protein 1 decreases expression EXP coumarin results in decreased expression of CSRP1 mRNA CTD PMID:18480146 NCBI chr13:47,158,171...47,179,388
Ensembl chr13:47,167,789...47,179,384
JBrowse link
G Ctf1 cardiotrophin 1 increases expression EXP coumarin results in increased expression of CTF1 mRNA CTD PMID:18480146 NCBI chr 1:182,328,035...182,336,346
Ensembl chr 1:182,328,090...182,333,335
JBrowse link
G Cth cystathionine gamma-lyase affects expression EXP coumarin affects the expression of CTH mRNA CTD PMID:16963487 NCBI chr 2:246,975,888...247,002,234
Ensembl chr 2:246,975,894...247,002,234
JBrowse link
G Ctnnb1 catenin beta 1 decreases expression ISO coumarin analog results in decreased expression of CTNNB1 mRNA CTD PMID:32578917 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Ctsb cathepsin B increases expression ISO coumarin analog results in increased expression of CTSB mRNA CTD PMID:32578917 NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500
JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 decreases expression EXP coumarin results in decreased expression of CXCL12 mRNA CTD PMID:18480146 NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168
JBrowse link
G Cyb561 cytochrome b-561 increases expression EXP coumarin results in increased expression of CYB561 mRNA CTD PMID:18480146 NCBI chr10:90,878,052...90,888,734
Ensembl chr10:90,878,054...90,884,787
JBrowse link
G Cycs cytochrome c, somatic increases expression ISO coumarin analog results in increased expression of CYCS mRNA CTD PMID:32578917 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases expression
affects expression
EXP coumarin results in decreased expression of CYP1A2 mRNA
coumarin affects the expression of CYP1A2 mRNA
CTD PMID:16963487 PMID:18480146 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp2a1 cytochrome P450, family 2, subfamily a, polypeptide 1 increases hydroxylation
decreases hydroxylation
ISO
EXP
CYP2A13 protein results in increased hydroxylation of coumarin
CYP2A6 protein results in increased hydroxylation of coumarin
CYP2A13 gene polymorphism results in decreased hydroxylation of coumarin
CTD PMID:12919726 PMID:17922361 NCBI chr 1:82,231,611...82,244,887
Ensembl chr 1:82,231,611...82,244,887
JBrowse link
G Cyp2a3 cytochrome P450, family 2, subfamily a, polypeptide 3 affects metabolic processing ISO CYP2A5 protein affects the metabolism of coumarin CTD PMID:10646973 NCBI chr 1:82,171,914...82,179,980
Ensembl chr 1:82,169,949...82,179,979
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 decreases expression EXP coumarin results in decreased expression of CYP2C mRNA CTD PMID:18480146 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 affects localization EXP coumarin affects the localization of CYP2E1 protein CTD PMID:28803882 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 affects expression EXP coumarin affects the expression of CYP3A2 mRNA CTD PMID:16963487 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp51 cytochrome P450, family 51 decreases expression EXP coumarin results in decreased expression of CYP51 mRNA CTD PMID:18480146 NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 decreases expression EXP coumarin results in decreased expression of CYP7A1 mRNA CTD PMID:18480146 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
JBrowse link
G Ddit4l DNA-damage-inducible transcript 4-like increases expression EXP coumarin results in increased expression of DDIT4L mRNA CTD PMID:18480146 NCBI chr 2:226,128,273...226,131,044
Ensembl chr 2:226,128,276...226,131,375
JBrowse link
G Ddost dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit increases expression EXP coumarin results in increased expression of DDOST mRNA CTD PMID:18480146 NCBI chr 5:150,522,297...150,529,413
Ensembl chr 5:150,522,242...150,529,413
JBrowse link
G Ddx31 DEAD-box helicase 31 decreases expression EXP coumarin results in decreased expression of DDX31 mRNA CTD PMID:18480146 NCBI chr 3:12,172,829...12,238,392
Ensembl chr 3:12,172,836...12,238,873
JBrowse link
G Dnajb11 DnaJ heat shock protein family (Hsp40) member B11 increases expression EXP coumarin results in increased expression of DNAJB11 mRNA CTD PMID:18480146 NCBI chr11:78,151,750...78,168,259
Ensembl chr11:78,150,429...78,180,407
JBrowse link
G Dnajb9 DnaJ heat shock protein family (Hsp40) member B9 affects expression EXP coumarin affects the expression of DNAJB9 mRNA CTD PMID:16963487 NCBI chr 6:61,270,385...61,276,795
Ensembl chr 6:61,269,913...61,275,063
JBrowse link
G Dnajc3 DnaJ heat shock protein family (Hsp40) member C3 increases expression EXP coumarin results in increased expression of DNAJC3 mRNA CTD PMID:18480146 NCBI chr15:96,025,729...96,065,114
Ensembl chr15:96,025,624...96,065,181
JBrowse link
G Dscc1 DNA replication and sister chromatid cohesion 1 increases expression EXP coumarin results in increased expression of DSCC1 mRNA CTD PMID:18480146 NCBI chr 7:86,482,588...86,498,212
Ensembl chr 7:86,482,588...86,498,212
JBrowse link
G Eci1 enoyl-CoA delta isomerase 1 affects expression EXP coumarin affects the expression of ECI1 mRNA CTD PMID:16963487 NCBI chr10:13,456,715...13,470,061
Ensembl chr10:13,456,563...13,470,061
JBrowse link
G Eef1e1 eukaryotic translation elongation factor 1 epsilon 1 increases expression EXP coumarin results in increased expression of EEF1E1 mRNA CTD PMID:18480146 NCBI chr17:26,148,652...26,159,358
Ensembl chr17:26,148,633...26,215,720
JBrowse link
G Ell3 elongation factor for RNA polymerase II 3 increases expression EXP coumarin results in increased expression of ELL3 mRNA CTD PMID:18480146 NCBI chr 3:108,413,035...108,417,181
Ensembl chr 3:108,410,448...108,417,132
JBrowse link
G Eme2 essential meiotic structure-specific endonuclease subunit 2 increases expression EXP coumarin results in increased expression of EME2 mRNA CTD PMID:18480146 NCBI chr10:13,913,216...13,915,991
Ensembl chr10:13,913,221...13,915,968
JBrowse link
G Ephx1 epoxide hydrolase 1 increases expression ISO coumarin results in increased expression of EPHX1 mRNA CTD PMID:17311802 NCBI chr13:92,714,315...92,744,124
Ensembl chr13:92,714,315...92,790,235
JBrowse link
G F9 coagulation factor IX increases response to substance ISO F9 exon polymorphism results in increased susceptibility to coumarin; F9 protein mutant form results in increased susceptibility to coumarin CTD PMID:11307814 NCBI chr  X:138,352,334...138,396,835
Ensembl chr  X:138,352,298...138,396,835
JBrowse link
G Fads1 fatty acid desaturase 1 decreases expression EXP coumarin results in decreased expression of FADS1 mRNA CTD PMID:18480146 NCBI chr 1:206,827,724...206,842,734
Ensembl chr 1:206,827,765...206,842,734
JBrowse link
G Fam111a FAM111 trypsin like peptidase A increases expression EXP coumarin results in increased expression of FAM111A mRNA CTD PMID:18480146 NCBI chr 1:209,640,865...209,656,551
Ensembl chr 1:209,640,953...209,656,547
JBrowse link
G Fasn fatty acid synthase affects expression EXP coumarin affects the expression of FASN mRNA CTD PMID:16963487 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
JBrowse link
G Fen1 flap structure-specific endonuclease 1 increases expression EXP coumarin results in increased expression of FEN1 mRNA CTD PMID:18480146 NCBI chr 1:206,845,126...206,849,821
Ensembl chr 1:206,844,884...206,850,003
JBrowse link
G Fgg fibrinogen gamma chain affects expression EXP coumarin affects the expression of FGG mRNA CTD PMID:16963487 NCBI chr 2:168,354,880...168,362,325
Ensembl chr 2:168,355,013...168,362,322
JBrowse link
G Fggy FGGY carbohydrate kinase domain containing decreases expression EXP coumarin results in decreased expression of FGGY mRNA CTD PMID:18480146 NCBI chr 5:110,398,866...110,786,019
Ensembl chr 5:110,398,863...110,786,017
JBrowse link
G Fkbp11 FKBP prolyl isomerase 11 increases expression EXP coumarin results in increased expression of FKBP11 mRNA CTD PMID:18480146 NCBI chr 7:129,871,870...129,877,760
Ensembl chr 7:129,871,870...129,875,303
JBrowse link
G Fmo1 flavin containing dimethylaniline monoxygenase 1 decreases expression EXP coumarin results in decreased expression of FMO1 mRNA CTD PMID:18480146 NCBI chr13:75,182,184...75,214,439
Ensembl chr13:75,182,176...75,214,647
JBrowse link
G Gas5 growth arrest specific 5 increases expression EXP coumarin results in increased expression of GAS5 mRNA CTD PMID:18480146 NCBI chr13:73,303,611...73,306,932 JBrowse link
G Gckr glucokinase regulator decreases expression EXP coumarin results in decreased expression of GCKR mRNA CTD PMID:18480146 NCBI chr 6:25,044,592...25,075,834
Ensembl chr 6:25,045,100...25,075,654
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression EXP coumarin results in increased expression of GCLC mRNA CTD PMID:18480146 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression EXP coumarin results in increased expression of GCLM mRNA CTD PMID:18480146 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
JBrowse link
G Gjb2 gap junction protein, beta 2 increases expression EXP coumarin results in increased expression of GJB2 mRNA CTD PMID:18480146 NCBI chr15:31,260,390...31,278,222
Ensembl chr15:31,260,357...31,278,177
JBrowse link
G Gk glycerol kinase decreases expression EXP coumarin results in decreased expression of GK mRNA CTD PMID:18480146 NCBI chr  X:50,162,089...50,238,707
Ensembl chr  X:50,163,123...50,238,631
JBrowse link
G Glb1 galactosidase, beta 1 increases expression EXP coumarin results in increased expression of GLB1 mRNA CTD PMID:18480146 NCBI chr 8:114,085,508...114,158,127
Ensembl chr 8:114,085,508...114,158,127
JBrowse link
G Gldc glycine decarboxylase decreases expression EXP coumarin results in decreased expression of GLDC mRNA CTD PMID:18480146 NCBI chr 1:227,883,247...227,962,119
Ensembl chr 1:227,883,249...227,962,097
JBrowse link
G Gpr108 G protein-coupled receptor 108 decreases expression EXP coumarin results in decreased expression of GPR108 mRNA CTD PMID:18480146 NCBI chr 9:2,120,740...2,131,771
Ensembl chr 9:2,120,744...2,132,572
JBrowse link
G Gpx1 glutathione peroxidase 1 affects expression EXP coumarin affects the expression of GPX1 mRNA CTD PMID:16963487 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
JBrowse link
G Gsr glutathione-disulfide reductase increases expression EXP coumarin results in increased expression of GSR mRNA CTD PMID:18480146 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Gsta1 glutathione S-transferase alpha 1 increases expression EXP coumarin results in increased expression of GSTA3 protein CTD PMID:9794803 NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121
JBrowse link
G Gsta2 glutathione S-transferase alpha 2 increases expression ISO coumarin results in increased expression of GSTA1 protein CTD PMID:11309284 NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798
JBrowse link
G Gsta3 glutathione S-transferase alpha 3 increases expression ISO coumarin results in increased expression of GSTA2 protein; coumarin results in increased expression of GSTA3 protein CTD PMID:11309284 NCBI chr 9:23,658,574...23,684,240
Ensembl chr 9:23,658,574...23,684,240
JBrowse link
G Gsta5 glutathione S-transferase alpha 5 increases expression EXP coumarin results in increased expression of GSTA5 protein CTD PMID:9794803 NCBI chr 8:79,105,561...79,117,472
Ensembl chr 8:79,105,661...79,117,472
JBrowse link
G Gsta6 glutathione S-transferase alpha 6 increases expression ISO coumarin results in increased expression of GSTA1 protein CTD PMID:11309284 NCBI chr 9:23,743,262...23,806,260
Ensembl chr 9:23,744,288...23,801,131
JBrowse link
G Gstm5 glutathione S-transferase, mu 5 increases expression EXP
ISO
coumarin results in increased expression of GSTM3 protein
coumarin results in increased expression of GSTM5 protein
CTD PMID:9794803 PMID:11309284 NCBI chr 2:195,531,627...195,534,562
Ensembl chr 2:195,531,495...195,534,553
JBrowse link
G Gstp1 glutathione S-transferase pi 1 increases expression ISO
EXP
coumarin results in increased expression of GSTP1 protein CTD PMID:9794803 PMID:11309284 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Gstt1 glutathione S-transferase theta 1 increases expression EXP coumarin results in increased expression of GSTT1 mRNA; coumarin results in increased expression of GSTT1 protein CTD PMID:9794803 PMID:9855024 PMID:10413528 NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585
JBrowse link
G Hal histidine ammonia lyase decreases expression EXP coumarin results in decreased expression of HAL mRNA CTD PMID:18480146 NCBI chr 7:28,007,449...28,037,701
Ensembl chr 7:28,006,972...28,037,701
JBrowse link
G Hao2 hydroxyacid oxidase 2 decreases expression EXP coumarin results in decreased expression of HAO2 mRNA CTD PMID:18480146 NCBI chr 2:186,200,137...186,232,997
Ensembl chr 2:186,200,504...186,224,425
JBrowse link
G Hba-a2 hemoglobin alpha, adult chain 2 multiple interactions EXP coumarin inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased glycosylation of HBA1 protein] CTD PMID:19647726 NCBI chr10:15,323,830...15,324,677 JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases expression ISO coumarin analog results in increased expression of HIF1A mRNA CTD PMID:32578917 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase increases expression EXP coumarin results in increased expression of HMGCR mRNA CTD PMID:18480146 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
JBrowse link
G Hsd17b1 hydroxysteroid (17-beta) dehydrogenase 1 multiple interactions ISO coumarin analog inhibits the reaction [[HSD17B1 protein co-treated with NADP] results in increased reduction of Estrone] CTD PMID:21232530 NCBI chr10:86,009,728...86,011,928
Ensembl chr10:86,009,728...86,011,927
JBrowse link
G Hsp90b1 heat shock protein 90 beta family member 1 increases expression EXP coumarin results in increased expression of HSP90B1 mRNA CTD PMID:18480146 NCBI chr 7:21,110,431...21,124,762
Ensembl chr 7:21,110,457...21,124,788
JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B increases expression EXP coumarin results in increased expression of HSPA1B mRNA CTD PMID:18480146 NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
JBrowse link
G Hyou1 hypoxia up-regulated 1 increases expression EXP coumarin results in increased expression of HYOU1 mRNA CTD PMID:18480146 NCBI chr 8:44,706,073...44,718,189
Ensembl chr 8:44,706,263...44,718,186
JBrowse link
G Igfals insulin-like growth factor binding protein, acid labile subunit decreases expression EXP coumarin results in decreased expression of IGFALS mRNA CTD PMID:18480146 NCBI chr10:13,897,468...13,903,920
Ensembl chr10:13,898,395...13,902,677
JBrowse link
G Il1b interleukin 1 beta increases expression
decreases expression
EXP
ISO
coumarin results in increased expression of IL1B mRNA
coumarin analog results in decreased expression of IL1B protein
CTD PMID:15135310 PMID:32578917 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 increases expression
decreases expression
EXP
ISO
coumarin results in increased expression of IL6 mRNA
coumarin analog results in decreased expression of IL6 mRNA; coumarin analog results in decreased expression of IL6 protein
CTD PMID:15135310 PMID:32578917 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Isyna1 inositol-3-phosphate synthase 1 increases expression EXP coumarin results in increased expression of ISYNA1 mRNA CTD PMID:18480146 NCBI chr16:18,839,143...18,841,979
Ensembl chr16:18,839,145...18,841,979
JBrowse link
G Josd2 Josephin domain containing 2 increases expression EXP coumarin results in increased expression of JOSD2 mRNA CTD PMID:18480146 NCBI chr 1:94,960,867...94,964,751
Ensembl chr 1:94,961,107...94,964,749
JBrowse link
G Kcnk2 potassium two pore domain channel subfamily K member 2 increases expression EXP coumarin results in increased expression of KCNK2 mRNA CTD PMID:18480146 NCBI chr13:100,766,101...100,963,435
Ensembl chr13:100,766,113...100,963,435
JBrowse link
G Kdr kinase insert domain receptor increases expression ISO coumarin analog results in increased expression of KDR mRNA CTD PMID:32578917 NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018
JBrowse link
G Kif20a kinesin family member 20A decreases expression EXP coumarin results in decreased expression of KIF20A mRNA CTD PMID:18480146 NCBI chr18:26,230,294...26,238,780
Ensembl chr18:26,230,230...26,238,780
JBrowse link
G Klf2 Kruppel-like factor 2 decreases expression EXP coumarin results in decreased expression of KLF2 mRNA CTD PMID:18480146 NCBI chr16:17,521,773...17,523,723
Ensembl chr16:17,514,552...17,523,944
JBrowse link
G Krt19 keratin 19 decreases expression EXP coumarin results in decreased expression of KRT19 mRNA CTD PMID:18480146 NCBI chr10:85,075,835...85,080,552 JBrowse link
G Kynu kynureninase decreases expression EXP coumarin results in decreased expression of KYNU mRNA CTD PMID:18480146 NCBI chr 3:27,778,646...27,929,470
Ensembl chr 3:27,778,772...27,929,488
JBrowse link
G Lad1 ladinin 1 increases expression EXP coumarin results in increased expression of LAD1 mRNA CTD PMID:18480146 NCBI chr13:47,249,605...47,263,967
Ensembl chr13:47,249,605...47,263,967
JBrowse link
G Lmf2 lipase maturation factor 2 increases expression EXP coumarin results in increased expression of LMF2 mRNA CTD PMID:18480146 NCBI chr 7:120,418,343...120,422,825
Ensembl chr 7:120,418,345...120,422,823
JBrowse link
G Lrp3 LDL receptor related protein 3 affects expression EXP coumarin affects the expression of LRP3 mRNA CTD PMID:16963487 NCBI chr 1:87,843,815...87,859,147
Ensembl chr 1:87,844,868...87,859,110
JBrowse link
G Mat1a methionine adenosyltransferase 1A affects expression EXP coumarin affects the expression of MAT1A mRNA CTD PMID:16963487 NCBI chr16:16,983,084...17,001,284
Ensembl chr16:16,983,022...17,001,274
JBrowse link
G Mbl2 mannose binding lectin 2 decreases expression EXP coumarin results in decreased expression of MBL2 mRNA CTD PMID:18480146 NCBI chr 1:228,016,439...228,024,736 JBrowse link
G Mcm2 minichromosome maintenance complex component 2 increases expression EXP coumarin results in increased expression of MCM2 mRNA CTD PMID:18480146 NCBI chr 4:121,346,434...121,360,962
Ensembl chr 4:121,346,434...121,360,847
JBrowse link
G Mcm3 minichromosome maintenance complex component 3 increases expression EXP coumarin results in increased expression of MCM3 mRNA CTD PMID:18480146 NCBI chr 9:23,219,169...23,237,314
Ensembl chr 9:23,219,169...23,237,314
JBrowse link
G Mcm4 minichromosome maintenance complex component 4 increases expression EXP coumarin results in increased expression of MCM4 mRNA CTD PMID:18480146 NCBI chr11:85,258,443...85,272,144
Ensembl chr11:85,258,443...85,272,144
JBrowse link
G Mcm5 minichromosome maintenance complex component 5 increases expression EXP coumarin results in increased expression of MCM5 mRNA CTD PMID:18480146 NCBI chr19:13,483,030...13,504,389
Ensembl chr19:13,483,066...13,504,389
JBrowse link
G Mdm2 MDM2 proto-oncogene decreases expression ISO coumarin analog results in decreased expression of MDM2 mRNA CTD PMID:32578917 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915
JBrowse link
G Mgp matrix Gla protein decreases expression ISO coumarin results in decreased expression of MGP mRNA CTD PMID:19350115 NCBI chr 4:169,766,290...169,769,612
Ensembl chr 4:169,766,279...169,769,667
JBrowse link
G Mgst2 microsomal glutathione S-transferase 2 increases expression EXP coumarin results in increased expression of MGST2 mRNA CTD PMID:18480146 NCBI chr 2:135,679,524...135,715,828
Ensembl chr 2:135,693,557...135,715,828
JBrowse link
G Mgst3 microsomal glutathione S-transferase 3 decreases expression EXP coumarin results in decreased expression of MGST3 mRNA CTD PMID:18480146 NCBI chr13:79,526,541...79,547,479
Ensembl chr13:79,526,541...79,547,411
JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression ISO coumarin analog results in decreased expression of MMP2 mRNA CTD PMID:32578917 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression
multiple interactions
ISO coumarin analog results in decreased expression of MMP9 mRNA
coumarin analog results in decreased expression of and results in decreased activity of MMP9 protein
CTD PMID:32578917 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mms22l MMS22-like, DNA repair protein increases expression EXP coumarin results in increased expression of MMS22L mRNA CTD PMID:18480146 NCBI chr 5:38,197,707...38,313,745
Ensembl chr 5:38,197,779...38,313,745
JBrowse link
G Msmo1 methylsterol monooxygenase 1 affects expression EXP coumarin affects the expression of MSMO1 mRNA CTD PMID:16963487 NCBI chr16:24,980,680...24,997,927
Ensembl chr16:24,980,697...24,998,016
JBrowse link
G Mt1 metallothionein 1 increases expression EXP coumarin results in increased expression of MT1A mRNA CTD PMID:18480146 NCBI chr19:10,826,032...10,827,048 JBrowse link
G Mt2A metallothionein 2A increases expression EXP coumarin results in increased expression of MT2A mRNA CTD PMID:18480146 NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784
JBrowse link
G Nectin2 nectin cell adhesion molecule 2 decreases expression EXP coumarin results in decreased expression of NECTIN2 mRNA CTD PMID:18480146 NCBI chr 1:79,372,123...79,407,379
Ensembl chr 1:79,372,119...79,407,360
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 affects activity
increases activity
ISO coumarin affects the activity of NFE2L2 protein
coumarin results in increased activity of NFE2L2 protein
CTD PMID:11309284 PMID:30114225 PMID:30203046 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nol3 nucleolar protein 3 increases expression EXP coumarin results in increased expression of NOL3 mRNA CTD PMID:18480146 NCBI chr19:33,154,061...33,158,250
Ensembl chr19:33,154,062...33,158,250
JBrowse link
G Nol8 nucleolar protein 8 increases expression EXP coumarin results in increased expression of NOL8 mRNA CTD PMID:18480146 NCBI chr17:14,990,394...15,013,784
Ensembl chr17:14,990,417...15,013,848
JBrowse link
G Nop56 NOP56 ribonucleoprotein increases expression EXP coumarin results in increased expression of NOP56 mRNA CTD PMID:18480146 NCBI chr 3:117,476,963...117,481,847
Ensembl chr 3:117,477,053...117,481,841
JBrowse link
G Nos2 nitric oxide synthase 2 increases expression EXP
ISO
coumarin results in increased expression of NOS2 mRNA
coumarin analog results in increased expression of NOS2 mRNA; coumarin analog results in increased expression of NOS2 protein
CTD PMID:15135310 PMID:32578917 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO
EXP
coumarin results in increased expression of NQO1 mRNA; coumarin results in increased expression of NQO1 protein CTD PMID:11309284 PMID:17311802 PMID:18480146 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 increases expression EXP coumarin results in increased expression of NR0B2 mRNA CTD PMID:18480146 NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609
JBrowse link
G Nr1d2 nuclear receptor subfamily 1, group D, member 2 increases expression EXP coumarin results in increased expression of NR1D2 mRNA CTD PMID:18480146 NCBI chr15:7,524,257...7,550,553
Ensembl chr15:7,524,257...7,550,553
JBrowse link
G Nrep neuronal regeneration related protein decreases expression EXP coumarin results in decreased expression of NREP mRNA CTD PMID:18480146 NCBI chr18:25,017,069...25,046,564
Ensembl chr18:25,017,083...25,046,591
JBrowse link
G Nrtn neurturin increases expression EXP coumarin results in increased expression of NRTN mRNA CTD PMID:18480146 NCBI chr 9:1,581,860...1,587,835
Ensembl chr 9:1,581,975...1,583,102
JBrowse link
G Ntng1 netrin G1 decreases expression EXP coumarin results in decreased expression of NTNG1 mRNA CTD PMID:18480146 NCBI chr 2:197,462,785...197,827,681
Ensembl chr 2:197,463,945...197,826,997
JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator increases expression EXP coumarin results in increased expression of NUPR1 mRNA CTD PMID:18480146 NCBI chr 1:181,213,292...181,215,327 JBrowse link
G Oaf out at first homolog decreases expression EXP coumarin results in decreased expression of OAF mRNA CTD PMID:18480146 NCBI chr 8:43,594,362...43,612,334
Ensembl chr 8:43,594,363...43,612,334
JBrowse link
G Oat ornithine aminotransferase decreases expression EXP coumarin results in decreased expression of OAT mRNA CTD PMID:18480146 NCBI chr 1:187,347,862...187,367,644
Ensembl chr 1:187,347,865...187,367,682
JBrowse link
G Ogn osteoglycin decreases expression EXP coumarin results in decreased expression of OGN mRNA CTD PMID:18480146 NCBI chr17:15,032,069...15,052,626
Ensembl chr17:15,032,069...15,052,739
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 decreases activity
decreases expression
increases cleavage
multiple interactions
ISO coumarin results in decreased activity of PARP1 protein
coumarin analog results in decreased expression of PARP1 mRNA
coumarin analog results in increased cleavage of PARP1 protein
[coumarin results in decreased activity of PARP1 protein] inhibits the reaction [Tetrachlorodibenzodioxin results in decreased abundance of NAD]; [coumarin results in decreased activity of PARP1 protein] inhibits the reaction [Tetrachlorodibenzodioxin results in decreased abundance of NADP]
CTD PMID:17669606 PMID:31199928 PMID:32578917 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pck2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) increases expression EXP coumarin results in increased expression of PCK2 mRNA CTD PMID:18480146 NCBI chr15:29,027,891...29,036,729
Ensembl chr15:29,027,894...29,037,283
JBrowse link
G Pcna proliferating cell nuclear antigen increases expression ISO coumarin analog results in increased expression of PCNA mRNA CTD PMID:32578917 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Pde4b phosphodiesterase 4B decreases expression EXP coumarin results in decreased expression of PDE4B mRNA CTD PMID:18480146 NCBI chr 5:116,799,827...117,367,707
Ensembl chr 5:116,799,971...117,367,696
JBrowse link
G Pdia3 protein disulfide isomerase family A, member 3 increases expression EXP coumarin results in increased expression of PDIA3 mRNA CTD PMID:18480146 NCBI chr 3:108,388,189...108,412,013
Ensembl chr 3:108,388,245...108,413,236
JBrowse link
G Pdia4 protein disulfide isomerase family A, member 4 increases expression EXP coumarin results in increased expression of PDIA4 mRNA CTD PMID:18480146 NCBI chr 4:76,803,198...76,822,245
Ensembl chr 4:76,803,198...76,822,107
JBrowse link
G Pdk2 pyruvate dehydrogenase kinase 2 decreases expression EXP coumarin results in decreased expression of PDK2 mRNA CTD PMID:18480146 NCBI chr10:79,972,550...79,987,074
Ensembl chr10:79,972,556...79,987,085
JBrowse link
G Pla2g12a phospholipase A2, group XIIA increases expression EXP coumarin results in increased expression of PLA2G12A mRNA CTD PMID:18480146 NCBI chr 2:218,436,450...218,452,760
Ensembl chr 2:218,436,513...218,452,740
JBrowse link
G Pold1 DNA polymerase delta 1, catalytic subunit increases expression EXP coumarin results in increased expression of POLD1 mRNA CTD PMID:18480146 NCBI chr 1:95,025,462...95,041,559
Ensembl chr 1:95,025,499...95,036,465
JBrowse link
G Pold2 DNA polymerase delta 2, accessory subunit increases expression EXP coumarin results in increased expression of POLD2 mRNA CTD PMID:18480146 NCBI chr14:80,748,971...80,755,188
Ensembl chr14:80,748,974...80,755,160
JBrowse link
G Polr1e RNA polymerase I subunit E increases expression EXP coumarin results in increased expression of POLR1E mRNA CTD PMID:18480146 NCBI chr 5:59,279,456...59,295,346
Ensembl chr 5:59,279,460...59,295,369
JBrowse link
G Ptgr1 prostaglandin reductase 1 increases expression EXP coumarin results in increased expression of PTGR1 mRNA CTD PMID:18480146 NCBI chr 5:73,784,000...73,802,624
Ensembl chr 5:73,784,009...73,802,666
JBrowse link
G R3hdm1 R3H domain containing 1 increases expression EXP coumarin results in increased expression of R3HDM1 mRNA CTD PMID:18480146 NCBI chr13:39,595,848...39,733,876
Ensembl chr13:39,595,848...39,733,876
JBrowse link
G R3hdm2 R3H domain containing 2 decreases expression EXP coumarin results in decreased expression of R3HDM2 mRNA CTD PMID:18480146 NCBI chr 7:63,212,519...63,340,574
Ensembl chr 7:63,232,346...63,340,540
JBrowse link
G Rab3d RAB3D, member RAS oncogene family increases expression EXP coumarin results in increased expression of RAB3D mRNA CTD PMID:18480146 NCBI chr 8:20,438,622...20,449,269
Ensembl chr 8:20,439,294...20,449,185
JBrowse link
G Rbm3 RNA binding motif protein 3 increases expression EXP coumarin results in increased expression of RBM3 mRNA CTD PMID:18480146 NCBI chr  X:14,348,909...14,352,387
Ensembl chr  X:14,348,910...14,353,580
JBrowse link
G Rbp1 retinol binding protein 1 decreases expression EXP coumarin results in decreased expression of RBP1 mRNA CTD PMID:18480146 NCBI chr 8:99,025,218...99,046,740
Ensembl chr 8:99,025,206...99,046,743
JBrowse link
G RGD1560171 similar to PRO0149 protein increases expression EXP coumarin results in increased expression of RGD1560171 mRNA CTD PMID:18480146 NCBI chr  X:138,921,816...138,924,124
Ensembl chr  X:138,922,100...138,922,918
JBrowse link
G RGD1564865 similar to 20-alpha-hydroxysteroid dehydrogenase decreases expression EXP coumarin results in decreased expression of RGD1564865 mRNA CTD PMID:18480146 NCBI chr17:65,847,580...65,881,488
Ensembl chr17:65,835,634...65,881,488
JBrowse link
G Rgn regucalcin decreases expression EXP coumarin results in decreased expression of RGN mRNA CTD PMID:18480146 NCBI chr  X:1,619,030...1,634,456
Ensembl chr  X:1,619,032...1,634,450
JBrowse link
G Rgs8 regulator of G-protein signaling 8 decreases expression EXP coumarin results in decreased expression of RGS8 mRNA CTD PMID:18480146 NCBI chr13:65,804,703...65,848,953
Ensembl chr13:65,804,797...65,846,807
JBrowse link
G Rprm reprimo, TP53 dependent G2 arrest mediator homolog decreases expression EXP coumarin results in decreased expression of RPRM mRNA CTD PMID:18480146 NCBI chr 3:38,539,581...38,540,998
Ensembl chr 3:38,539,581...38,540,998
JBrowse link
G RT1-Ba RT1 class II, locus Ba increases expression EXP coumarin results in increased expression of RT1-BA mRNA CTD PMID:18480146 NCBI chr20:4,575,134...4,579,727
Ensembl chr20:4,575,134...4,579,744
JBrowse link
G RT1-DMa RT1 class II, locus DMa increases expression EXP coumarin results in increased expression of HLA-DMA mRNA CTD PMID:18480146 NCBI chr20:4,707,028...4,710,432
Ensembl chr20:4,707,028...4,710,432
JBrowse link
G RT1-EC2 RT1 class Ib, locus EC2 increases expression EXP coumarin results in increased expression of RT1-EC2 mRNA CTD PMID:18480146
G Saraf store-operated calcium entry-associated regulatory factor increases expression EXP coumarin results in increased expression of SARAF mRNA CTD PMID:18480146 NCBI chr16:58,017,231...58,035,481
Ensembl chr16:58,017,231...58,035,545
JBrowse link
G Scd stearoyl-CoA desaturase decreases expression EXP coumarin results in decreased expression of SCD1 mRNA CTD PMID:18480146 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
JBrowse link
G Sdf2l1 stromal cell-derived factor 2-like 1 increases expression EXP coumarin results in increased expression of SDF2L1 mRNA CTD PMID:18480146 NCBI chr11:83,872,659...83,874,902
Ensembl chr11:83,872,659...83,874,902
JBrowse link
G Sel1l SEL1L adaptor subunit of ERAD E3 ubiquitin ligase increases expression EXP coumarin results in increased expression of SEL1L mRNA CTD PMID:18480146 NCBI chr 6:110,735,450...110,779,695
Ensembl chr 6:110,735,450...110,779,648
JBrowse link
G Sema6d semaphorin 6D increases expression EXP coumarin results in increased expression of SEMA6D mRNA CTD PMID:18480146 NCBI chr 3:111,883,415...111,941,100
Ensembl chr 3:111,883,872...111,941,094
JBrowse link
G Slc17a1 solute carrier family 17 member 1 increases expression EXP coumarin results in increased expression of SLC17A1 mRNA CTD PMID:18480146 NCBI chr17:41,219,461...41,255,199 JBrowse link
G Slc17a3 solute carrier family 17 member 3 increases expression EXP coumarin results in increased expression of SLC17A3 mRNA CTD PMID:18480146 NCBI chr17:41,270,804...41,300,132
Ensembl chr17:41,270,812...41,295,256
JBrowse link
G Slc1a2 solute carrier family 1 member 2 increases expression EXP coumarin results in increased expression of SLC1A2 mRNA CTD PMID:18480146 NCBI chr 3:89,005,129...89,126,498
Ensembl chr 3:89,005,129...89,126,498
JBrowse link
G Slc27a2 solute carrier family 27 member 2 affects expression EXP coumarin affects the expression of SLC27A2 mRNA CTD PMID:16963487 NCBI chr 3:113,804,728...113,842,208
Ensembl chr 3:113,804,728...113,842,208
JBrowse link
G Slc28a2 solute carrier family 28 member 2 decreases expression EXP coumarin results in decreased expression of SLC28A2 mRNA CTD PMID:18480146 NCBI chr 3:109,324,815...109,387,702
Ensembl chr 3:109,366,996...109,387,702
JBrowse link
G Slc35e3 solute carrier family 35, member E3 increases expression EXP coumarin results in increased expression of SLC35E3 mRNA CTD PMID:18480146 NCBI chr 7:53,337,091...53,350,152
Ensembl chr 7:53,337,095...53,350,165
JBrowse link
G Slc6a13 solute carrier family 6 member 13 decreases expression EXP coumarin results in decreased expression of SLC6A13 mRNA CTD PMID:18480146 NCBI chr 4:154,539,246...154,577,784
Ensembl chr 4:154,540,468...154,576,152
JBrowse link
G Slc6a9 solute carrier family 6 member 9 increases expression EXP coumarin results in increased expression of SLC6A9 mRNA CTD PMID:18480146 NCBI chr 5:131,374,562...131,408,733
Ensembl chr 5:131,374,542...131,408,728
JBrowse link
G Smpdl3b sphingomyelin phosphodiesterase, acid-like 3B increases expression EXP coumarin results in increased expression of SMPDL3B mRNA CTD PMID:18480146 NCBI chr 5:144,944,618...144,966,703
Ensembl chr 5:144,944,636...144,966,720
JBrowse link
G Snai2 snail family transcriptional repressor 2 decreases expression ISO coumarin analog results in decreased expression of SNAI2 mRNA CTD PMID:32578917 NCBI chr11:86,183,800...86,186,109
Ensembl chr11:86,181,909...86,186,200
JBrowse link
G Srxn1 sulfiredoxin 1 increases expression EXP coumarin results in increased expression of SRXN1 mRNA CTD PMID:18480146 NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448
JBrowse link
G Stat5b signal transducer and activator of transcription 5B increases activity ISO coumarin results in increased activity of STAT5B protein CTD PMID:30114225 NCBI chr10:85,704,841...85,775,856
Ensembl chr10:85,705,670...85,775,668
JBrowse link
G Sult1b1 sulfotransferase family 1B member 1 affects expression EXP coumarin affects the expression of SULT1B1 mRNA CTD PMID:16963487 NCBI chr14:20,492,763...20,505,491
Ensembl chr14:20,492,708...20,505,483
JBrowse link
G Sult1c3 sulfotransferase family 1C member 3 decreases expression EXP coumarin results in decreased expression of SULT1C1 mRNA CTD PMID:18480146 NCBI chr 9:7,221,580...7,266,991
Ensembl chr 9:7,221,578...7,267,030
JBrowse link
G Sult1e1 sulfotransferase family 1E member 1 decreases expression EXP coumarin results in decreased expression of SULT1E1 mRNA CTD PMID:18480146 NCBI chr14:20,422,324...20,439,562
Ensembl chr14:20,422,324...20,439,275
JBrowse link
G Sycp3 synaptonemal complex protein 3 decreases expression EXP coumarin results in decreased expression of SYCP3 mRNA CTD PMID:18480146 NCBI chr 7:22,874,055...22,888,512
Ensembl chr 7:22,874,055...22,888,511
JBrowse link
G Syne4 spectrin repeat containing nuclear envelope family member 4 increases expression EXP coumarin results in increased expression of SYNE4 mRNA CTD PMID:18480146 NCBI chr 1:85,569,409...85,573,775
Ensembl chr 1:85,569,545...85,573,760
JBrowse link
G Tfrc transferrin receptor increases expression EXP coumarin results in increased expression of TFRC mRNA CTD PMID:18480146 NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257
JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression ISO coumarin analog results in increased expression of TGFB1 mRNA CTD PMID:32578917 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Thra thyroid hormone receptor alpha increases expression EXP coumarin results in increased expression of THRA mRNA CTD PMID:18480146 NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936
JBrowse link
G Thrsp thyroid hormone responsive affects expression
decreases expression
EXP coumarin affects the expression of THRSP mRNA
coumarin results in decreased expression of THRSP mRNA
CTD PMID:16963487 PMID:18480146 NCBI chr 1:151,723,415...151,727,740
Ensembl chr 1:151,723,086...151,728,075
JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 increases expression ISO coumarin analog results in increased expression of TIMP2 mRNA CTD PMID:32578917 NCBI chr10:103,541,199...103,590,611 JBrowse link
G Timp4 TIMP metallopeptidase inhibitor 4 increases expression ISO coumarin analog results in increased expression of TIMP4 mRNA CTD PMID:32578917 NCBI chr 4:148,306,021...148,312,558
Ensembl chr 4:148,304,490...148,312,558
JBrowse link
G Tmed3 transmembrane p24 trafficking protein 3 increases expression EXP coumarin results in increased expression of TMED3 mRNA CTD PMID:18480146 NCBI chr 8:90,241,516...90,249,429
Ensembl chr 8:90,241,516...90,249,346
JBrowse link
G Tnf tumor necrosis factor increases expression EXP
ISO
coumarin results in increased expression of TNF mRNA
coumarin analog results in increased expression of TNF protein
CTD PMID:15135310 PMID:32578917 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfrsf9 TNF receptor superfamily member 9 decreases expression EXP coumarin results in decreased expression of TNFRSF9 mRNA CTD PMID:18480146 NCBI chr 5:161,381,662...161,408,003
Ensembl chr 5:161,381,662...161,408,000
JBrowse link
G Tp53 tumor protein p53 increases expression ISO coumarin analog results in increased expression of TP53 mRNA; coumarin analog results in increased expression of TP53 protein CTD PMID:32578917 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Tradd TNFRSF1A-associated via death domain increases expression ISO coumarin analog results in increased expression of TRADD mRNA CTD PMID:32578917 NCBI chr19:33,136,148...33,142,714
Ensembl chr19:33,136,138...33,142,638
JBrowse link
G Trpc2 transient receptor potential cation channel subfamily C member 2 increases expression EXP coumarin results in increased expression of TRPC2 mRNA CTD PMID:18480146 NCBI chr 1:156,460,009...156,473,039
Ensembl chr 1:156,440,305...156,473,073
JBrowse link
G Tsc22d1 TSC22 domain family, member 1 decreases expression EXP coumarin results in decreased expression of TSC22D1 mRNA CTD PMID:18480146 NCBI chr15:51,750,489...51,850,958
Ensembl chr15:51,749,510...51,850,958
JBrowse link
G Tst thiosulfate sulfurtransferase affects expression EXP coumarin affects the expression of TST mRNA CTD PMID:16963487 NCBI chr 7:109,948,061...109,955,378
Ensembl chr 7:109,948,062...109,957,216
JBrowse link
G Ttc39a tetratricopeptide repeat domain 39A increases expression EXP coumarin results in increased expression of TTC39A mRNA CTD PMID:18480146 NCBI chr 5:124,165,102...124,204,973
Ensembl chr 5:124,151,760...124,204,973
JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression EXP coumarin results in increased expression of TXNRD1 mRNA CTD PMID:18480146 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
JBrowse link
G Ugdh UDP-glucose 6-dehydrogenase increases expression EXP coumarin results in increased expression of UGDH mRNA CTD PMID:18480146 NCBI chr14:42,848,704...42,872,351
Ensembl chr14:42,848,854...42,872,354
JBrowse link
G Ugt2b UDP glycosyltransferase 2 family, polypeptide B decreases expression EXP coumarin results in decreased expression of UGT2B mRNA CTD PMID:18480146 NCBI chr14:20,630,572...20,665,062
Ensembl chr14:20,630,250...20,651,776
JBrowse link
G Ust5r integral membrane transport protein UST5r decreases expression EXP coumarin results in decreased expression of UST5R mRNA CTD PMID:18480146 NCBI chr 1:205,210,558...205,286,868
Ensembl chr 1:205,211,034...205,286,718
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO coumarin analog results in increased expression of VEGFA mRNA CTD PMID:32578917 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Vim vimentin decreases expression ISO coumarin analog results in decreased expression of VIM protein CTD PMID:32578917 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
JBrowse link
G Vkorc1 vitamin K epoxide reductase complex, subunit 1 decreases response to substance
increases response to substance
ISO VKORC1 gene mutant form results in decreased susceptibility to coumarin
VKORC1 gene mutant form results in increased susceptibility to coumarin; VKORC1 promoter SNP results in increased susceptibility to coumarin
CTD PMID:17849045 PMID:18278162 NCBI chr 1:182,502,491...182,505,012
Ensembl chr 1:182,500,844...182,505,008
JBrowse link
G Wee1 WEE1 G2 checkpoint kinase increases expression EXP coumarin results in increased expression of WEE1 mRNA CTD PMID:18480146 NCBI chr 1:164,173,681...164,197,688
Ensembl chr 1:164,174,779...164,197,688
JBrowse link
G Yrdc yrdC N(6)-threonylcarbamoyltransferase domain containing increases expression EXP coumarin results in increased expression of YRDC mRNA CTD PMID:18480146 NCBI chr 5:137,110,244...137,115,127
Ensembl chr 5:137,110,279...137,115,120
JBrowse link
G Zeb1 zinc finger E-box binding homeobox 1 decreases expression ISO coumarin analog results in decreased expression of ZEB1 mRNA CTD PMID:32578917 NCBI chr17:51,948,948...52,116,018
Ensembl chr17:51,948,948...52,115,214
JBrowse link
G Zfp444 zinc finger protein 444 increases expression EXP coumarin results in increased expression of ZFP444 mRNA CTD PMID:18480146 NCBI chr 1:67,709,052...67,729,283
Ensembl chr 1:67,711,152...67,728,367
JBrowse link
G Zfp593 zinc finger protein 593 increases expression EXP coumarin results in increased expression of ZNF593 mRNA CTD PMID:18480146 NCBI chr 5:146,462,670...146,464,998
Ensembl chr 5:146,462,670...146,465,198
JBrowse link
G Zwint ZW10 interacting kinetochore protein increases expression EXP coumarin results in increased expression of ZWINT mRNA CTD PMID:18480146 NCBI chr20:15,938,157...15,953,997
Ensembl chr20:15,938,157...15,953,957
JBrowse link
coumarin 460 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akap9 A-kinase anchoring protein 9 increases expression ISO 4-methyl-7-diethylaminocoumarin results in increased expression of AKAP9 mRNA CTD PMID:19502547 NCBI chr 4:30,056,738...30,192,716
Ensembl chr 4:30,056,738...30,192,606
JBrowse link
G Ankrd37 ankyrin repeat domain 37 increases expression ISO 4-methyl-7-diethylaminocoumarin results in increased expression of ANKRD37 mRNA CTD PMID:19502547 NCBI chr16:46,269,025...46,271,971
Ensembl chr16:46,268,443...46,271,963
JBrowse link
G Ar androgen receptor multiple interactions
affects localization
ISO 4-methyl-7-diethylaminocoumarin binds to and results in increased activity of AR protein
4-methyl-7-diethylaminocoumarin affects the localization of AR protein
CTD PMID:28478275 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases activity ISO 4-methyl-7-diethylaminocoumarin results in increased activity of HIF1A protein CTD PMID:19502547 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Pfkm phosphofructokinase, muscle increases expression ISO 4-methyl-7-diethylaminocoumarin results in increased expression of PFKM mRNA CTD PMID:19502547 NCBI chr 7:129,221,679...129,259,192
Ensembl chr 7:129,221,653...129,259,192
JBrowse link
G Psph phosphoserine phosphatase increases expression ISO 4-methyl-7-diethylaminocoumarin results in increased expression of PSPH mRNA CTD PMID:19502547 NCBI chr12:26,882,524...26,905,084
Ensembl chr12:26,883,133...26,905,074
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO 4-methyl-7-diethylaminocoumarin results in increased expression of VEGFA protein CTD PMID:19502547 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
coumarins term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aifm1 apoptosis inducing factor, mitochondria associated 1 affects localization ISO Coumarins affects the localization of AIFM1 protein CTD PMID:19705353 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Coumarins analog results in decreased expression of BCL2 protein CTD PMID:25231984 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO Coumarins analog results in decreased expression of BIRC5 protein CTD PMID:25231984 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO Coumarins analog results in decreased expression of CCND1 protein CTD PMID:25231984 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions ISO [CYP2D6 protein results in increased metabolism of 7-methoxy-4-(aminomethyl)coumarin] which results in increased chemical synthesis of Coumarins; Quinidine inhibits the reaction [[CYP2D6 protein results in increased metabolism of 7-methoxy-4-(aminomethyl)coumarin] which results in increased chemical synthesis of Coumarins] CTD PMID:23850985 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Esr1 estrogen receptor 1 decreases expression ISO Coumarins analog results in decreased expression of ESR1 protein CTD PMID:17275315 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Ifng interferon gamma multiple interactions ISO Coumarins inhibits the reaction [Dextran Sulfate results in increased expression of IFNG protein] CTD PMID:25231984 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il10 interleukin 10 multiple interactions ISO Coumarins inhibits the reaction [Dextran Sulfate results in decreased expression of IL10 protein] CTD PMID:25231984 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Coumarins inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein] CTD PMID:25231984 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Coumarins inhibits the reaction [Dextran Sulfate results in increased expression of IL6 protein] CTD PMID:25231984 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression ISO Coumarins analog results in decreased expression of MCL1 protein CTD PMID:25231984 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO Coumarins inhibits the reaction [Dextran Sulfate results in increased activity of MPO protein] CTD PMID:25231984 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO Coumarins analog results in increased cleavage of PARP1 protein CTD PMID:25231984 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pon1 paraoxonase 1 increases hydrolysis ISO PON1 protein results in increased hydrolysis of Coumarins CTD PMID:20353174 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360
JBrowse link
G Pon2 paraoxonase 2 increases hydrolysis ISO PON2 protein results in increased hydrolysis of Coumarins CTD PMID:20353174 NCBI chr 4:33,389,702...33,425,186
Ensembl chr 4:33,389,714...33,425,248
JBrowse link
G Pon3 paraoxonase 3 increases hydrolysis ISO PON3 protein results in increased hydrolysis of Coumarins analog CTD PMID:16099434 PMID:16139510 NCBI chr 4:33,356,983...33,383,681
Ensembl chr 4:33,349,168...33,383,855
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases phosphorylation ISO Coumarins analog results in decreased phosphorylation of RELA protein CTD PMID:25231984 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Tnf tumor necrosis factor multiple interactions
affects binding
ISO Coumarins analog inhibits the reaction [[Thioglycolates co-treated with Lipopolysaccharides] results in increased expression of TNF protein]; Coumarins inhibits the reaction [Dextran Sulfate results in increased expression of TNF protein]
Coumarins analog binds to TNF protein
CTD PMID:25231984 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 multiple interactions ISO
EXP
Coumarins analog promotes the reaction [UGT1A1 protein results in increased glucuronidation of Bilirubin] CTD PMID:17599282 NCBI chr 9:88,801,344...88,808,465 JBrowse link
G Vkorc1 vitamin K epoxide reductase complex, subunit 1 affects activity ISO Coumarins affects the activity of VKORC1 protein CTD PMID:18278162 NCBI chr 1:182,502,491...182,505,012
Ensembl chr 1:182,500,844...182,505,008
JBrowse link
Coumatetralyl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Vkorc1 vitamin K epoxide reductase complex, subunit 1 decreases response to substance
multiple interactions
decreases activity
EXP
ISO
VKORC1 protein polymorphism results in decreased susceptibility to coumatetralyl
coumatetralyl inhibits the reaction [VKORC1 protein results in increased reduction of Vitamin K 1]
coumatetralyl results in decreased activity of VKORC1 protein
CTD PMID:27117082 PMID:29581108 NCBI chr 1:182,502,491...182,505,012
Ensembl chr 1:182,500,844...182,505,008
JBrowse link
G Vkorc1l1 vitamin K epoxide reductase complex, subunit 1-like 1 multiple interactions
decreases activity
ISO coumatetralyl inhibits the reaction [VKORC1L1 protein results in increased reduction of Vitamin K 1]
coumatetralyl results in decreased activity of VKORC1L1 protein
CTD PMID:29581108 NCBI chr12:26,717,959...26,768,193 JBrowse link
cyanidin cation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor increases activity ISO cyanidin results in increased activity of AHR protein CTD PMID:23419638 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Ccn1 cellular communication network factor 1 multiple interactions ISO
EXP
cyanidin inhibits the reaction [[IL17A protein co-treated with Freund's Adjuvant] results in increased expression of CCN1 protein]
cyanidin inhibits the reaction [Freund's Adjuvant results in increased expression of CCN1 protein]
CTD PMID:32044269 NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484
JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions EXP
ISO
cyanidin inhibits the reaction [Freund's Adjuvant results in increased expression of CSF2 protein]
cyanidin inhibits the reaction [[IL17A protein co-treated with Freund's Adjuvant] results in increased expression of CSF2 mRNA]; cyanidin inhibits the reaction [[IL17A protein co-treated with Freund's Adjuvant] results in increased expression of CSF2 protein]
CTD PMID:32044269 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
JBrowse link
G Hbegf heparin-binding EGF-like growth factor multiple interactions ISO cyanidin inhibits the reaction [Sodium Chloride results in increased expression of HBEGF mRNA] CTD PMID:26800359 NCBI chr18:28,106,284...28,116,167
Ensembl chr18:28,105,760...28,116,441
JBrowse link
G Hlcs holocarboxylase synthetase decreases activity ISO cyanidin results in decreased activity of HLCS protein CTD PMID:26303405 NCBI chr11:33,455,806...33,635,197
Ensembl chr11:33,455,809...33,624,222
JBrowse link
G Hmox1 heme oxygenase 1 affects expression ISO cyanidin affects the expression of HMOX1 protein CTD PMID:26505893 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Il17a interleukin 17A multiple interactions ISO [cyanidin inhibits the reaction [[IL17A protein co-treated with Freund's Adjuvant] results in increased expression of and results in increased phosphorylation of STAT3 protein]] which results in increased expression of PIAS3 protein; cyanidin inhibits the reaction [[IL17A protein co-treated with Freund's Adjuvant] results in increased expression of and results in increased phosphorylation of STAT3 protein]; cyanidin inhibits the reaction [[IL17A protein co-treated with Freund's Adjuvant] results in increased expression of CCN1 protein]; cyanidin inhibits the reaction [[IL17A protein co-treated with Freund's Adjuvant] results in increased expression of CSF2 mRNA]; cyanidin inhibits the reaction [[IL17A protein co-treated with Freund's Adjuvant] results in increased expression of CSF2 protein]; cyanidin inhibits the reaction [[IL17A protein co-treated with Freund's Adjuvant] results in increased expression of IL17RA mRNA]; cyanidin inhibits the reaction [[IL17A protein co-treated with Freund's Adjuvant] results in increased expression of IL17RA protein]; cyanidin inhibits the reaction [[IL17A protein co-treated with Freund's Adjuvant] results in increased expression of IL23A mRNA]; cyanidin inhibits the reaction [[IL17A protein co-treated with Freund's Adjuvant] results in increased expression of IL23A protein]; cyanidin inhibits the reaction [[IL17A protein co-treated with Freund's Adjuvant] results in increased expression of PCNA protein]; cyanidin inhibits the reaction [[IL17A protein co-treated with Freund's Adjuvant] results in increased expression of TLR3 protein]; cyanidin inhibits the reaction [[IL17A protein co-treated with Freund's Adjuvant] results in increased phosphorylation of JAK1 protein]; cyanidin inhibits the reaction [[IL17A protein co-treated with Freund's Adjuvant] results in increased phosphorylation of JAK3 protein]; cyanidin inhibits the reaction [IL17A protein promotes the reaction [Freund's Adjuvant results in increased expression of TLR3 protein]] CTD PMID:32044269 NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
JBrowse link
G Il17ra interleukin 17 receptor A multiple interactions ISO cyanidin inhibits the reaction [[IL17A protein co-treated with Freund's Adjuvant] results in increased expression of IL17RA mRNA]; cyanidin inhibits the reaction [[IL17A protein co-treated with Freund's Adjuvant] results in increased expression of IL17RA protein] CTD PMID:32044269 NCBI chr 4:153,667,534...153,690,174
Ensembl chr 4:153,667,534...153,690,174
JBrowse link
G Il23a interleukin 23 subunit alpha multiple interactions ISO
EXP
cyanidin inhibits the reaction [[IL17A protein co-treated with Freund's Adjuvant] results in increased expression of IL23A mRNA]; cyanidin inhibits the reaction [[IL17A protein co-treated with Freund's Adjuvant] results in increased expression of IL23A protein]
cyanidin inhibits the reaction [Freund's Adjuvant results in increased expression of IL23A protein]
CTD PMID:32044269 NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923
JBrowse link
G Jak1 Janus kinase 1 multiple interactions ISO cyanidin inhibits the reaction [[IL17A protein co-treated with Freund's Adjuvant] results in increased phosphorylation of JAK1 protein] CTD PMID:32044269 NCBI chr 5:115,780,248...115,888,841
Ensembl chr 5:115,780,248...115,888,926
JBrowse link
G Jak3 Janus kinase 3 multiple interactions ISO cyanidin inhibits the reaction [[IL17A protein co-treated with Freund's Adjuvant] results in increased phosphorylation of JAK3 protein] CTD PMID:32044269 NCBI chr16:18,386,330...18,398,542
Ensembl chr16:18,386,405...18,398,536
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases activity
affects expression
EXP
ISO
cyanidin results in increased activity of NFE2L2 protein
cyanidin affects the expression of NFE2L2 protein
CTD PMID:26505893 PMID:27166148 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nos3 nitric oxide synthase 3 increases expression ISO cyanidin results in increased expression of NOS3 mRNA CTD PMID:15740983 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO cyanidin inhibits the reaction [[IL17A protein co-treated with Freund's Adjuvant] results in increased expression of PCNA protein] CTD PMID:32044269 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Pdgfa platelet derived growth factor subunit A multiple interactions ISO cyanidin inhibits the reaction [[PDGFA protein co-treated with PDGFB protein] results in increased abundance of Reactive Oxygen Species]; cyanidin inhibits the reaction [[PDGFA protein co-treated with PDGFB protein] results in increased secretion of VEGFA protein] CTD PMID:16921400 NCBI chr12:15,645,549...15,667,056
Ensembl chr12:15,645,541...15,666,497
JBrowse link
G Pdgfb platelet derived growth factor subunit B multiple interactions ISO cyanidin inhibits the reaction [[PDGFA protein co-treated with PDGFB protein] results in increased abundance of Reactive Oxygen Species]; cyanidin inhibits the reaction [[PDGFA protein co-treated with PDGFB protein] results in increased secretion of VEGFA protein] CTD PMID:16921400 NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984
JBrowse link
G Pias3 protein inhibitor of activated STAT, 3 multiple interactions ISO [cyanidin inhibits the reaction [[IL17A protein co-treated with Freund's Adjuvant] results in increased expression of and results in increased phosphorylation of STAT3 protein]] which results in increased expression of PIAS3 protein CTD PMID:32044269 NCBI chr 2:184,232,546...184,241,455
Ensembl chr 2:184,232,571...184,241,480
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO
EXP
[cyanidin inhibits the reaction [[IL17A protein co-treated with Freund's Adjuvant] results in increased expression of and results in increased phosphorylation of STAT3 protein]] which results in increased expression of PIAS3 protein; cyanidin inhibits the reaction [[IL17A protein co-treated with Freund's Adjuvant] results in increased expression of and results in increased phosphorylation of STAT3 protein]
cyanidin inhibits the reaction [Freund's Adjuvant results in increased phosphorylation of STAT3 protein]
CTD PMID:32044269 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Tlr3 toll-like receptor 3 multiple interactions ISO
EXP
cyanidin inhibits the reaction [[IL17A protein co-treated with Freund's Adjuvant] results in increased expression of TLR3 protein]; cyanidin inhibits the reaction [IL17A protein promotes the reaction [Freund's Adjuvant results in increased expression of TLR3 protein]]
cyanidin inhibits the reaction [Freund's Adjuvant results in increased expression of TLR3 protein]
CTD PMID:32044269 NCBI chr16:46,821,980...46,837,900
Ensembl chr16:46,822,039...46,836,545
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO cyanidin inhibits the reaction [Benzo(a)pyrene results in increased expression of TNF mRNA] CTD PMID:28533128 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Ucp2 uncoupling protein 2 multiple interactions ISO cyanidin inhibits the reaction [Benzo(a)pyrene results in increased expression of UCP2 mRNA] CTD PMID:28533128 NCBI chr 1:154,839,242...154,845,612
Ensembl chr 1:154,839,209...154,845,611
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO cyanidin inhibits the reaction [[PDGFA protein co-treated with PDGFB protein] results in increased secretion of VEGFA protein]; cyanidin inhibits the reaction [cobaltous chloride results in increased expression of VEGFA mRNA] CTD PMID:16921400 PMID:26800359 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
Decursin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity ISO decursin results in decreased activity of ACHE protein CTD PMID:12482674 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Ar androgen receptor increases degradation
multiple interactions
ISO decursin results in increased degradation of AR protein
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [decursin results in increased degradation of AR protein]; decursin results in decreased localization of and results in decreased expression of AR protein
CTD PMID:17723170 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Cat catalase multiple interactions ISO [decursin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CAT protein CTD PMID:31351099 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO decursin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CCL2 protein] CTD PMID:31351099 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 multiple interactions ISO decursin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CCL4 protein] CTD PMID:31351099 NCBI chr10:68,466,469...68,467,941
Ensembl chr10:68,452,052...68,468,231
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions ISO decursin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CHUK protein] CTD PMID:31351099 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions ISO decursin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CXCL2 protein] CTD PMID:31351099 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO decursin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ICAM1 protein] CTD PMID:31351099 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Ifng interferon gamma multiple interactions ISO decursin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IFNG protein] CTD PMID:31351099 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Ikbkg inhibitor of nuclear factor kappa B kinase regulatory subunit gamma multiple interactions ISO decursin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IKBKG protein] CTD PMID:31351099 NCBI chr  X:152,216,485...152,241,476
Ensembl chr  X:152,216,596...152,239,499
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO decursin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL1B protein] CTD PMID:31351099 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions ISO decursin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL6 protein] CTD PMID:31351099 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO decursin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein] CTD PMID:31351099 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO decursin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK3 protein] CTD PMID:31351099 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO decursin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of NFKBIA protein] CTD PMID:31351099 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions ISO decursin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of NOS1 protein] CTD PMID:31351099 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO decursin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of NOS2 protein] CTD PMID:31351099 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO decursin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of NOS3 protein] CTD PMID:31351099 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO decursin results in increased cleavage of PARP1 protein CTD PMID:17723170 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO decursin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein] CTD PMID:31351099 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO decursin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of RELA protein] CTD PMID:31351099 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO [decursin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of SOD1 protein CTD PMID:31351099 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO [decursin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of SOD2 protein CTD PMID:31351099 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO decursin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TNF protein] CTD PMID:31351099 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
delphinidin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO delphinidin inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein] CTD PMID:20371262 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator multiple interactions ISO delphinidin inhibits the reaction [Hydrogen Peroxide results in increased expression of ARNT protein] CTD PMID:18603805 NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580
JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases expression ISO delphinidin results in increased expression of BAK1 protein CTD PMID:29451351 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
decreases expression
ISO delphinidin results in increased expression of BAX protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [delphinidin promotes the reaction [TGFB1 results in decreased expression of BAX protein]]; delphinidin promotes the reaction [TGFB1 results in decreased expression of BAX protein]
delphinidin results in decreased expression of BAX protein
CTD PMID:15740068 PMID:19818742 PMID:30365941 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
increases expression
ISO delphinidin results in decreased expression of BCL2 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [delphinidin inhibits the reaction [TGFB1 results in decreased expression of BCL2 protein]]; delphinidin inhibits the reaction [TGFB1 results in decreased expression of BCL2 protein]
delphinidin results in increased expression of BCL2 protein
CTD PMID:15740068 PMID:19818742 PMID:29451351 PMID:30365941 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions ISO [delphinidin results in increased susceptibility to sodium arsenite] which results in decreased expression of BID protein CTD PMID:30125548 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
JBrowse link
G Btg2 BTG anti-proliferation factor 2 affects expression ISO delphinidin affects the expression of BTG2 mRNA CTD PMID:19182879 NCBI chr13:45,531,881...45,535,642
Ensembl chr13:45,531,925...45,535,628
JBrowse link
G Casp3 caspase 3 increases activity
increases cleavage
multiple interactions
ISO delphinidin results in increased activity of CASP3 protein
delphinidin results in increased cleavage of CASP3 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [delphinidin inhibits the reaction [TGFB1 results in increased expression of CASP3 protein]]; [delphinidin results in increased susceptibility to sodium arsenite] which results in increased cleavage of CASP3 protein; delphinidin inhibits the reaction [TGFB1 results in increased expression of CASP3 protein]
CTD PMID:15740068 PMID:29451351 PMID:30125548 PMID:30365941 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 multiple interactions ISO [delphinidin results in increased susceptibility to sodium arsenite] which results in increased cleavage of CASP8 protein CTD PMID:30125548 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 multiple interactions ISO [delphinidin results in increased susceptibility to sodium arsenite] which results in increased cleavage of CASP9 protein CTD PMID:30125548 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cdh1 cadherin 1 increases expression ISO delphinidin results in increased expression of CDH1 protein CTD PMID:29451351 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Cdh2 cadherin 2 decreases expression ISO delphinidin results in decreased expression of CDH2 protein CTD PMID:29451351 NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167
JBrowse link
G Cidea cell death-inducing DFFA-like effector a increases expression ISO delphinidin results in increased expression of CIDEA mRNA CTD PMID:19182879 NCBI chr18:60,894,917...60,920,485
Ensembl chr18:60,894,874...60,920,481
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity ISO delphinidin results in decreased activity of CYP1A1 protein CTD PMID:23419638 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Egfr epidermal growth factor receptor decreases phosphorylation ISO delphinidin results in decreased phosphorylation of EGFR protein CTD PMID:18618485 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Epas1 endothelial PAS domain protein 1 multiple interactions ISO delphinidin inhibits the reaction [Hydrogen Peroxide results in increased expression of EPAS1 protein] CTD PMID:18603805 NCBI chr 6:7,790,236...7,871,246
Ensembl chr 6:7,790,647...7,871,228
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 decreases phosphorylation ISO delphinidin results in decreased phosphorylation of ERBB2 protein CTD PMID:18618485 NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO delphinidin inhibits the reaction [Hydrogen Peroxide results in increased expression of HIF1A protein] CTD PMID:18603805 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Hif3a hypoxia inducible factor 3 subunit alpha multiple interactions ISO delphinidin inhibits the reaction [Hydrogen Peroxide results in increased expression of HIF3A protein] CTD PMID:18603805 NCBI chr 1:77,718,110...77,750,448
Ensembl chr 1:77,722,471...77,749,758
JBrowse link
G Hmox1 heme oxygenase 1 increases expression EXP delphinidin results in increased expression of HMOX1 protein CTD PMID:30266311 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression ISO delphinidin results in increased expression of JUN mRNA CTD PMID:15740068 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation ISO delphinidin results in decreased phosphorylation of MAPK1 protein CTD PMID:18618485 PMID:29451351 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation ISO delphinidin results in decreased phosphorylation of MAPK3 protein CTD PMID:18618485 PMID:29451351 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO delphinidin results in increased phosphorylation of and results in increased activity of MAPK8 protein CTD PMID:15740068 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO delphinidin promotes the reaction [Carbon Tetrachloride results in increased expression of MMP9 protein] CTD PMID:20371262 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Nbn nibrin increases expression ISO delphinidin results in increased expression of NBN mRNA CTD PMID:19182879 NCBI chr 5:29,459,574...29,494,152
Ensembl chr 5:29,459,457...29,494,150
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 decreases activity
increases cleavage
ISO delphinidin results in decreased activity of PARP1 protein
delphinidin results in increased cleavage of PARP1 protein
CTD PMID:17884996 PMID:29451351 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pcbp4 poly(rC) binding protein 4 affects expression ISO delphinidin affects the expression of PCBP4 mRNA CTD PMID:19182879 NCBI chr 8:107,092,688...107,103,276
Ensembl chr 8:107,093,013...107,103,276
JBrowse link
G Pdgfa platelet derived growth factor subunit A multiple interactions ISO delphinidin inhibits the reaction [[PDGFA protein co-treated with PDGFB protein] results in increased abundance of Reactive Oxygen Species]; delphinidin inhibits the reaction [[PDGFA protein co-treated with PDGFB protein] results in increased secretion of VEGFA protein] CTD PMID:16921400 NCBI chr12:15,645,549...15,667,056
Ensembl chr12:15,645,541...15,666,497
JBrowse link
G Pdgfb platelet derived growth factor subunit B multiple interactions ISO delphinidin inhibits the reaction [[PDGFA protein co-treated with PDGFB protein] results in increased abundance of Reactive Oxygen Species]; delphinidin inhibits the reaction [[PDGFA protein co-treated with PDGFB protein] results in increased secretion of VEGFA protein] CTD PMID:16921400 NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984
JBrowse link
G Pgk1 phosphoglycerate kinase 1 multiple interactions ISO delphinidin inhibits the reaction [Hydrogen Peroxide results in increased expression of PGK1 protein] CTD PMID:18603805 NCBI chr  X:71,271,454...71,287,429
Ensembl chr  X:71,271,440...71,287,418
JBrowse link
G Snai1 snail family transcriptional repressor 1 decreases expression ISO delphinidin results in decreased expression of SNAI1 protein CTD PMID:29451351 NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969
JBrowse link
G Snai2 snail family transcriptional repressor 2 decreases expression ISO delphinidin results in decreased expression of SNAI2 protein CTD PMID:29451351 NCBI chr11:86,183,800...86,186,109
Ensembl chr11:86,181,909...86,186,200
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO delphinidin inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [delphinidin inhibits the reaction [TGFB1 results in decreased expression of BCL2 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [delphinidin inhibits the reaction [TGFB1 results in increased expression of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [delphinidin promotes the reaction [TGFB1 results in decreased expression of BAX protein]]; delphinidin inhibits the reaction [TGFB1 results in decreased expression of BCL2 protein]; delphinidin inhibits the reaction [TGFB1 results in increased abundance of Malondialdehyde]; delphinidin inhibits the reaction [TGFB1 results in increased abundance of Reactive Oxygen Species]; delphinidin inhibits the reaction [TGFB1 results in increased expression of CASP3 protein]; delphinidin promotes the reaction [TGFB1 results in decreased expression of BAX protein]
CTD PMID:20371262 PMID:30365941 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO delphinidin inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein] CTD PMID:20371262 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Top1 DNA topoisomerase I decreases activity ISO delphinidin results in decreased activity of TOP1 protein CTD PMID:19182879 NCBI chr 3:149,293,658...149,375,405
Ensembl chr 3:149,293,403...149,376,623
JBrowse link
G Top2a DNA topoisomerase II alpha decreases activity
multiple interactions
ISO delphinidin results in decreased activity of TOP2A protein
delphinidin results in decreased susceptibility to [Doxorubicin affects the activity of TOP2A protein]; delphinidin results in decreased susceptibility to [Etoposide affects the activity of TOP2A protein]
CTD PMID:19182879 NCBI chr10:83,946,186...83,975,694
Ensembl chr10:83,945,735...83,976,874
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO delphinidin inhibits the reaction [[PDGFA protein co-treated with PDGFB protein] results in increased secretion of VEGFA protein] CTD PMID:16921400 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641