Pxn (paxillin) - Rat Genome Database

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Gene: Pxn (paxillin) Mus musculus
Analyze
Symbol: Pxn
Name: paxillin
RGD ID: 1313985
MGI Page MGI
Description: Enables BH4 domain binding activity; MAP-kinase scaffold activity; and neuropilin binding activity. Involved in positive regulation of angiogenesis and transforming growth factor beta receptor signaling pathway. Acts upstream of or within several processes, including focal adhesion assembly; integrin-mediated signaling pathway; and substrate adhesion-dependent cell spreading. Located in focal adhesion and lamellipodium. Is expressed in several structures, including early conceptus; genitourinary system; immune system; inner ear; and telencephalon. Orthologous to human PXN (paxillin); PARTICIPATES IN ephrin - ephrin receptor bidirectional signaling axis; insulin-like growth factor signaling pathway; integrin mediated signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 1,8-cineole; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AW108311; AW123232; P; Pax
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395115,630,153 - 115,694,046 (+)NCBIGRCm39mm39
GRCm39 Ensembl5115,644,735 - 115,694,046 (+)Ensembl
GRCm385115,491,970 - 115,555,987 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5115,506,676 - 115,555,987 (+)EnsemblGRCm38mm10GRCm38
MGSCv375115,956,711 - 116,005,995 (+)NCBIGRCm37mm9NCBIm37
MGSCv365115,767,751 - 115,815,656 (+)NCBImm8
Celera5112,606,134 - 112,661,101 (+)NCBICelera
Cytogenetic Map5FNCBI
cM Map556.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-mevalonic acid  (ISO)
1,2-dimethylhydrazine  (EXP)
1,8-cineole  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4-hydroxycoumarin  (EXP)
4-hydroxyphenyl retinamide  (EXP)
4-vinylcyclohexene dioxide  (EXP)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
Anetholtrithion  (ISO)
aristolochic acid  (ISO)
arsenite(3-)  (EXP)
atropine  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (ISO)
BQ 123  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calciol  (ISO)
carbamazepine  (ISO)
chlorpyrifos  (EXP,ISO)
cisplatin  (EXP)
cobalt dichloride  (ISO)
cyclosporin A  (ISO)
D-glucose  (EXP)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
dieldrin  (ISO)
diethyl maleate  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
endosulfan  (ISO)
enzyme inhibitor  (ISO)
ethanol  (EXP)
formaldehyde  (ISO)
genistein  (ISO)
glucose  (EXP)
heparin  (EXP)
hydrogen peroxide  (EXP)
ibuprofen  (ISO)
isoflavones  (ISO)
lithium chloride  (ISO)
lithocholic acid  (ISO)
methamphetamine  (EXP)
methotrexate  (ISO)
methoxychlor  (EXP)
microcystin-LR  (ISO)
oxotremorine M  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenylarsine oxide  (ISO)
phenylmercury acetate  (ISO)
reactive oxygen species  (ISO)
resveratrol  (EXP,ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
simvastatin  (ISO)
sodium arsenite  (ISO)
Soman  (ISO)
terbinafine  (ISO)
toxaphene  (ISO)
troglitazone  (EXP)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
tungsten  (EXP)
valproic acid  (ISO)
vinclozolin  (ISO)
vorinostat  (ISO)
wortmannin  (ISO)
xanthohumol  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cell junction  (IEA)
cell leading edge  (IDA)
cell-cell junction  (ISO)
cytoplasm  (IEA)
cytoskeleton  (IEA)
cytosol  (IBA,ISO)
focal adhesion  (IBA,IDA,ISO,TAS)
lamellipodium  (IDA,ISO)
plasma membrane  (IBA,ISO)
stress fiber  (ISO)

References

Additional References at PubMed
PMID:7544435   PMID:8641358   PMID:8889548   PMID:8978305   PMID:9418872   PMID:9603926   PMID:9712867   PMID:10349636   PMID:10512203   PMID:10613908   PMID:10637315   PMID:10809671  
PMID:10931187   PMID:11004510   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11238916   PMID:11704675   PMID:11784715   PMID:11784865   PMID:11787067   PMID:11791180   PMID:11807098  
PMID:11825902   PMID:12153727   PMID:12198769   PMID:12477932   PMID:12520002   PMID:12548551   PMID:12695331   PMID:12837288   PMID:12904583   PMID:14500722   PMID:14576348   PMID:14580336  
PMID:14610273   PMID:14636584   PMID:14699151   PMID:14975240   PMID:15023529   PMID:15107421   PMID:15138291   PMID:15242880   PMID:15252114   PMID:15340073   PMID:15467718   PMID:15494312  
PMID:15728191   PMID:15782199   PMID:15831480   PMID:15840001   PMID:15889232   PMID:15893749   PMID:16000375   PMID:16141072   PMID:16141073   PMID:16298995   PMID:16317044   PMID:16339552  
PMID:16399995   PMID:16428445   PMID:16478788   PMID:16537926   PMID:16814769   PMID:17164291   PMID:17233630   PMID:18045996   PMID:18187040   PMID:18216331   PMID:18287559   PMID:18464795  
PMID:18486129   PMID:18794329   PMID:18799693   PMID:19124607   PMID:19126677   PMID:19168634   PMID:19349584   PMID:19542491   PMID:19628583   PMID:19812308   PMID:19917054   PMID:20011539  
PMID:20097761   PMID:20133777   PMID:20308429   PMID:20388733   PMID:20412781   PMID:20442405   PMID:20525696   PMID:20737513   PMID:20886612   PMID:21084629   PMID:21107430   PMID:21195757  
PMID:21267068   PMID:21289086   PMID:21418380   PMID:21430700   PMID:21873635   PMID:21898535   PMID:21900245   PMID:21965722   PMID:22043013   PMID:22194823   PMID:22328507   PMID:22349694  
PMID:22446089   PMID:22629443   PMID:22629471   PMID:22684108   PMID:22750292   PMID:22807029   PMID:22865050   PMID:22959909   PMID:22988430   PMID:22989773   PMID:23076140   PMID:23128389  
PMID:23658024   PMID:23936270   PMID:23990882   PMID:24036928   PMID:24096476   PMID:24595293   PMID:24642576   PMID:24681597   PMID:24841562   PMID:24863063   PMID:24868594   PMID:24885567  
PMID:25070956   PMID:25217619   PMID:25231004   PMID:25239564   PMID:25330109   PMID:25488665   PMID:25742295   PMID:25795725   PMID:26159543   PMID:26212757   PMID:26253403   PMID:26881253  
PMID:27181366   PMID:27184837   PMID:27256596   PMID:27269065   PMID:27565344   PMID:27864010   PMID:28153048   PMID:28315297   PMID:28536193   PMID:28546219   PMID:28912124   PMID:28924218  
PMID:28935710   PMID:28954813   PMID:29638158   PMID:30718399   PMID:30967426   PMID:31101859   PMID:31180501   PMID:31537712   PMID:33243234   PMID:33253712  


Genomics

Comparative Map Data
Pxn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395115,630,153 - 115,694,046 (+)NCBIGRCm39mm39
GRCm39 Ensembl5115,644,735 - 115,694,046 (+)Ensembl
GRCm385115,491,970 - 115,555,987 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5115,506,676 - 115,555,987 (+)EnsemblGRCm38mm10GRCm38
MGSCv375115,956,711 - 116,005,995 (+)NCBIGRCm37mm9NCBIm37
MGSCv365115,767,751 - 115,815,656 (+)NCBImm8
Celera5112,606,134 - 112,661,101 (+)NCBICelera
Cytogenetic Map5FNCBI
cM Map556.1NCBI
PXN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl12120,210,439 - 120,265,771 (-)EnsemblGRCh38hg38GRCh38
GRCh3812120,210,447 - 120,265,737 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3712120,648,250 - 120,703,533 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3612119,132,640 - 119,187,892 (-)NCBINCBI36hg18NCBI36
Build 3412119,110,976 - 119,166,229NCBI
Celera12120,281,352 - 120,336,672 (-)NCBI
Cytogenetic Map12q24.23NCBI
HuRef12117,656,442 - 117,711,723 (-)NCBIHuRef
CHM1_112120,616,253 - 120,671,571 (-)NCBICHM1_1
Pxn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21241,060,791 - 41,107,962 (-)NCBImRatBN7.2
Rnor_6.0 Ensembl1246,797,954 - 46,845,080 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01246,797,953 - 46,845,107 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01248,595,399 - 48,642,177 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41242,322,193 - 42,370,507 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11242,185,581 - 42,233,895 (-)NCBI
Celera1242,684,240 - 42,731,375 (-)NCBICelera
Cytogenetic Map12q16NCBI
Pxn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545511,388,378 - 11,403,082 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545511,387,140 - 11,401,178 (+)NCBIChiLan1.0ChiLan1.0
PXN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.112121,160,295 - 121,200,695 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12121,160,295 - 121,176,667 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v012117,785,614 - 117,840,816 (-)NCBIMhudiblu_PPA_v0panPan3
PXN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12616,157,231 - 16,224,028 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2616,159,025 - 16,184,820 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2616,161,797 - 16,210,046 (-)NCBI
ROS_Cfam_1.02616,424,969 - 16,473,447 (-)NCBI
UMICH_Zoey_3.12616,385,989 - 16,434,224 (-)NCBI
UNSW_CanFamBas_1.02616,463,118 - 16,511,352 (-)NCBI
UU_Cfam_GSD_1.02616,504,096 - 16,552,543 (-)NCBI
Pxn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118146,161,497 - 146,210,393 (+)NCBI
SpeTri2.0NW_004936668660,415 - 709,282 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PXN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1440,227,894 - 40,278,766 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11440,227,894 - 40,278,785 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
PXN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111115,560,859 - 115,619,093 (-)NCBI
ChlSab1.1 Ensembl11115,560,662 - 115,619,029 (-)Ensembl
Vero_WHO_p1.0NW_023666037129,487,668 - 129,546,391 (+)NCBI
Pxn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474713,371,128 - 13,435,619 (+)NCBI

Position Markers
AW123232  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385115,555,577 - 115,555,668UniSTSGRCm38
MGSCv375116,005,586 - 116,005,677UniSTSGRCm37
Celera5112,660,692 - 112,660,783UniSTS
Cytogenetic Map5FUniSTS
cM Map560.0UniSTS
Whitehead/MRC_RH51409.04UniSTS
AW108311  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385115,554,893 - 115,555,008UniSTSGRCm38
MGSCv375116,004,902 - 116,005,017UniSTSGRCm37
Celera5112,660,008 - 112,660,123UniSTS
Cytogenetic Map5FUniSTS
cM Map560.0UniSTS
Whitehead/MRC_RH51411.66UniSTS
PMC133539P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385115,543,910 - 115,544,536UniSTSGRCm38
MGSCv375115,993,919 - 115,994,545UniSTSGRCm37
Celera5112,649,051 - 112,649,677UniSTS
Cytogenetic Map5FUniSTS
cM Map560.0UniSTS
Pxn  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5FUniSTS
cM Map560.0UniSTS
cM Map560.0UniSTS
Pxn  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5FUniSTS
Pxn  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5FUniSTS
cM Map560.0UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301457Cfsw2_mcystic fibrosis survival to weaning 2 (mouse)Not determined590413140124413285Mouse
1300940Actd3_mactivity-distance traveled 3 (mouse)Not determined596172519130172667Mouse
1301858Smdq1_msegregation of mitochondrial DNA QTL 1 (mouse)Not determined596883692130883925Mouse
1301543Hypch_mhypercholesterolemia (mouse)Not determined5109090758139133150Mouse
1301974Chab7_mcholesterol absorption 7 (mouse)Not determined595085348129085464Mouse
1300801Drb2_mdopamine receptor binding 2 (mouse)Not determined587239005121239199Mouse
1357431Cia27_mcollagen induced arthritis 27 (mouse)Not determined575154687119880564Mouse
1357644Egrd1_mearly growth rate, direct effect 1 (mouse)Not determined595286714129286920Mouse
1357662Lprq4_mlipoprotein QTL 4 (mouse)Not determined5113883692129555542Mouse
4141519Hmtb5_mhemostasis and thrombosis bleeding time 5 (mouse)Not determined99801563126805880Mouse
1300659Pcd8ts1_mp-glycoprotein positive CD8 T cell subset 1 (mouse)Not determined596883692130883925Mouse
1558774Lith17_mlithogenic gene 17 (mouse)Not determined595317683129317856Mouse
1301362Prnr1_mprion resistance 1 (mouse)Not determined589271017146851125Mouse
1301399Cpfd3_mcerebellum pattern fissures (mouse)Not determined587239005121239199Mouse
1301042Elmaz1_melevated maze behavior 1 (mouse)Not determined597871790116738565Mouse
1357725Eae39_mexperimental allergic encephalomyelitis 39 (mouse)Not determined589271017118725963Mouse
1300913Bwefm_mbody weight females and males day 10 (mouse)Not determined5109362284143362395Mouse
1301226Bbaa2_mB.burgdorferi-associated arthritis 2 (mouse)Not determined5115128044149128176Mouse
1301102Cia14_mcollagen induced arthritis 14 (mouse)Not determined5113172519138557193Mouse
1301126Bwem1_mbody weight day 30 males 1 (mouse)Not determined587239005121239199Mouse
4141139Hmtb4_mhemostasis and thrombosis rebleeding time 4 (mouse)Not determined108614643126805880Mouse
1300827Cora1_mcorrelation in cytokine production 1 (mouse)Not determined5115128044149128176Mouse
1300968Skts4_mskin tumor susceptibility 4 (mouse)Not determined589271017124100176Mouse
1300993Hycdc_mhypercapnic duty cycle (mouse)Not determined590413140124413285Mouse
1301624Aevm2_mautoimmune extremity vasculitis in MRL mice 2 (mouse)Not determined5101725767135725963Mouse
4141652Mrdq2_mmodifier of retinal degeneration QTL 2 (mouse)Not determined110105240117955608Mouse
9587780Afw16_mabdominal fat weight QTL 16 (mouse)Not determined592682300126682419Mouse
10043890Trigq4_mtriglyceride QTL 4 (mouse)Not determined5107829235141829348Mouse
10401245Bglu18_mblood glucose level 18 (mouse)Not determined582690609116690738Mouse
10043958Chldq12_mcholesterol and HDL QTL 12 (mouse)Not determined587239005121239199Mouse
10402486Dipa1_mdrug induced psychomotor activation 1 (mouse)Not determined595317683129317856Mouse
10412197Bbaa25_mB.burgdorferi-associated arthritis 25 (mouse)Not determined5109090176143090317Mouse
10412202Bbaa26_mB.burgdorferi-associated arthritis 26 (mouse)Not determined5104435822138557193Mouse
10412239Alpq7_malcohol preference QTL 7 (mouse)Not determined5104567876138567876Mouse
4142473Chlq11_mcirculating hormone level QTL 11 (mouse)Not determined5107829235141829348Mouse
4142064Tmc1m4_mTmc1 modifier 4 (mouse)Not determined554342835126924008Mouse
12904959Smmq1_msoleus muscle mass QTL 1 (mouse)5100527900134527900Mouse
13464244Ahl19_mage related hearing loss, early onset 19 (mouse)595317683129317856Mouse
11528550Sluc33_msusceptibility to lung cancer 33 (mouse)5104239005120573921Mouse
13506928Recrq8_mrecombination rate in male meiosis QTL 8 (mouse)574300000132500000Mouse
13464242Ahl17_mage related hearing loss, early onset 17 (mouse)582690609116690738Mouse
26884395Humsd2_mhumerus midshaft diameter 2, 10 week (mouse)569900000132500000Mouse
13464251Ahl21_mage related hearing loss, early onset 21 (mouse)5109090176143090317Mouse
11341716Rvfs3_mRift Valley fever susceptibility 3 (mouse)526236236138457140Mouse
13464243Ahl20_mage related hearing loss, early onset 20 (mouse)5107829235141829348Mouse
11049562Lmr24f_mleishmaniasis resistance 24f (mouse)590173096124173175Mouse
12859290Criq2_mCitrobacter rodentium infection QTL 2 (mouse)5101194514135194514Mouse
11532736Sluc33b_msusceptibility to lung cancer 33b (mouse)5102806972136807131Mouse
14746986Manh58_mmandible shape 58 (mouse)5102308218136308218Mouse
12904945Tammq2_mtibialis anterior muscle mass QTL 2 (mouse)5100527900134527900Mouse
27226719Tibw6_mtibia width 6, proximal, 16 week (mouse)572700000140000000Mouse
25314315Mlh1fc4_mMLH1 foci count 4 (mouse)574300000132500000Mouse
13464241Ahl18_mage related hearing loss, early onset 18 (mouse)587239005121239199Mouse

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir218-2mmu-miR-218-5pOncomiRDBexternal_infoNANA21159652

Predicted Target Of
Summary Value
Count of predictions:3330
Count of miRNA genes:755
Interacting mature miRNAs:985
Transcripts:ENSMUST00000067268, ENSMUST00000086523, ENSMUST00000125007, ENSMUST00000125054, ENSMUST00000127345, ENSMUST00000129897, ENSMUST00000134198, ENSMUST00000137716, ENSMUST00000138139, ENSMUST00000139834, ENSMUST00000152156, ENSMUST00000153682, ENSMUST00000157050
Prediction methods:Microtar, Miranda, Rnahybrid, Rnahybrid,Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_011223 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_133915 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006530202 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006530204 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006530205 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006530207 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030254218 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036164917 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036164918 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036164919 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004942462 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB014482 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC159539 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF293882 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF293883 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK084243 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK148060 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK149933 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK167299 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK171226 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK171436 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK180209 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK191714 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK194144 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK195488 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK197379 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK198032 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK198760 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK205143 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK206113 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK206605 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK208911 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK209978 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK211839 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK213554 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK214527 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK214775 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK215379 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK215544 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK218322 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK219507 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AV025054 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW123232 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC003298 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC025493 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY198095 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000067268   ⟹   ENSMUSP00000069624
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl5115,506,676 - 115,555,987 (+)Ensembl
RefSeq Acc Id: ENSMUST00000086523   ⟹   ENSMUSP00000083709
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl5115,506,808 - 115,554,978 (+)Ensembl
RefSeq Acc Id: ENSMUST00000125007
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl5115,520,305 - 115,555,982 (+)Ensembl
RefSeq Acc Id: ENSMUST00000125054
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl5115,544,796 - 115,549,756 (+)Ensembl
RefSeq Acc Id: ENSMUST00000129897
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl5115,516,355 - 115,544,883 (+)Ensembl
RefSeq Acc Id: ENSMUST00000134198
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl5115,544,114 - 115,544,948 (+)Ensembl
RefSeq Acc Id: ENSMUST00000137716   ⟹   ENSMUSP00000144513
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl5115,542,914 - 115,546,880 (+)Ensembl
RefSeq Acc Id: ENSMUST00000138139
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl5115,551,939 - 115,552,792 (+)Ensembl
RefSeq Acc Id: ENSMUST00000139834
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl5115,545,304 - 115,545,775 (+)Ensembl
RefSeq Acc Id: ENSMUST00000152156
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl5115,506,711 - 115,555,982 (+)Ensembl
RefSeq Acc Id: ENSMUST00000153682
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl5115,543,947 - 115,545,412 (+)Ensembl
RefSeq Acc Id: ENSMUST00000157050   ⟹   ENSMUSP00000143926
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl5115,542,950 - 115,546,835 (+)Ensembl
RefSeq Acc Id: ENSMUST00000202564   ⟹   ENSMUSP00000144459
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl5115,544,085 - 115,554,501 (+)Ensembl
RefSeq Acc Id: ENSMUST00000212819   ⟹   ENSMUSP00000148843
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl5115,506,856 - 115,554,135 (+)Ensembl
RefSeq Acc Id: NM_011223   ⟹   NP_035353
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395115,644,735 - 115,694,046 (+)NCBI
GRCm385115,506,676 - 115,555,987 (+)NCBI
MGSCv375115,956,711 - 116,005,995 (+)RGD
Celera5112,649,463 - 112,661,102 (+)NCBI
cM Map5 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_133915   ⟹   NP_598676
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395115,644,735 - 115,694,046 (+)NCBI
GRCm385115,506,676 - 115,555,987 (+)NCBI
MGSCv375115,956,711 - 116,005,995 (+)RGD
Celera5112,649,463 - 112,661,102 (+)NCBI
cM Map5 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006530202   ⟹   XP_006530265
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395115,644,735 - 115,694,046 (+)NCBI
GRCm385115,506,676 - 115,555,987 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006530204   ⟹   XP_006530267
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395115,680,965 - 115,694,046 (+)NCBI
GRCm385115,542,907 - 115,555,987 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006530205   ⟹   XP_006530268
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395115,680,964 - 115,694,046 (+)NCBI
GRCm385115,542,907 - 115,555,987 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006530207   ⟹   XP_006530270
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395115,644,735 - 115,688,771 (+)NCBI
GRCm385115,506,676 - 115,550,703 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030254218   ⟹   XP_030110078
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395115,630,153 - 115,694,046 (+)NCBI
GRCm385115,491,970 - 115,555,987 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036164917   ⟹   XP_036020810
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395115,644,735 - 115,694,046 (+)NCBI
RefSeq Acc Id: XM_036164918   ⟹   XP_036020811
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395115,644,735 - 115,694,046 (+)NCBI
RefSeq Acc Id: XM_036164919   ⟹   XP_036020812
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395115,644,735 - 115,688,284 (+)NCBI
RefSeq Acc Id: XR_004942462
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395115,644,735 - 115,688,662 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_598676   ⟸   NM_133915
- Peptide Label: isoform beta
- UniProtKB: Q8VI36 (UniProtKB/Swiss-Prot),   F8VQ28 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_035353   ⟸   NM_011223
- Peptide Label: isoform alpha
- UniProtKB: Q8VI36 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006530265   ⟸   XM_006530202
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006530270   ⟸   XM_006530207
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_006530268   ⟸   XM_006530205
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_006530267   ⟸   XM_006530204
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_030110078   ⟸   XM_030254218
- Peptide Label: isoform X7
RefSeq Acc Id: ENSMUSP00000083709   ⟸   ENSMUST00000086523
RefSeq Acc Id: ENSMUSP00000144459   ⟸   ENSMUST00000202564
RefSeq Acc Id: ENSMUSP00000069624   ⟸   ENSMUST00000067268
RefSeq Acc Id: ENSMUSP00000148843   ⟸   ENSMUST00000212819
RefSeq Acc Id: ENSMUSP00000144513   ⟸   ENSMUST00000137716
RefSeq Acc Id: ENSMUSP00000143926   ⟸   ENSMUST00000157050
RefSeq Acc Id: XP_036020810   ⟸   XM_036164917
- Peptide Label: isoform X2
RefSeq Acc Id: XP_036020811   ⟸   XM_036164918
- Peptide Label: isoform X4
RefSeq Acc Id: XP_036020812   ⟸   XM_036164919
- Peptide Label: isoform X6
Protein Domains
LIM zinc-binding

Promoters
RGD ID:6887754
Promoter ID:EPDNEW_M7328
Type:initiation region
Name:Pxn_1
Description:Mus musculus paxillin , transcript variant alpha, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M7329  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm385115,506,712 - 115,506,772EPDNEW
RGD ID:6887756
Promoter ID:EPDNEW_M7329
Type:initiation region
Name:Pxn_2
Description:Mus musculus paxillin , transcript variant alpha, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M7328  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm385115,544,776 - 115,544,836EPDNEW
RGD ID:6838165
Promoter ID:MM_KWN:43677
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_133915,   OTTMUST00000034817,   OTTMUST00000034852
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv365115,956,561 - 115,957,061 (+)MPROMDB
RGD ID:6838168
Promoter ID:MM_KWN:43679
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   ES_Cell,   Kidney,   Lung
Transcripts:OTTMUST00000034853
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv365115,965,391 - 115,966,697 (+)MPROMDB
RGD ID:6838163
Promoter ID:MM_KWN:43680
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour,   Kidney,   Liver,   Lung
Transcripts:OTTMUST00000034820
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv365115,970,361 - 115,970,861 (+)MPROMDB
RGD ID:6838166
Promoter ID:MM_KWN:43681
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_4Hour,   Kidney,   Liver,   Lung,   Spleen
Transcripts:ENSMUST00000112060,   OTTMUST00000034854,   OTTMUST00000034855
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv365115,992,614 - 115,993,114 (+)MPROMDB
RGD ID:6838167
Promoter ID:MM_KWN:43682
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Kidney,   Liver,   Lung
Transcripts:OTTMUST00000034819,   OTTMUST00000034856,   OTTMUST00000034857,   OTTMUST00000034858,   OTTMUST00000041025
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv365115,993,221 - 115,994,972 (+)MPROMDB
RGD ID:6838170
Promoter ID:MM_KWN:43683
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Kidney,   Lung
Transcripts:OTTMUST00000034859
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv365116,001,006 - 116,002,272 (+)MPROMDB
RGD ID:6847943
Promoter ID:MM_ACW:39117
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:PXN.FSEP07-UNSPLICED
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv365116,003,471 - 116,003,971 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:108295 AgrOrtholog
Ensembl Genes ENSMUSG00000029528 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000069624 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000083709 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSP00000143926 UniProtKB/TrEMBL
  ENSMUSP00000144459 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSP00000144513 UniProtKB/TrEMBL
  ENSMUSP00000148843 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000067268 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000086523 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000137716 UniProtKB/TrEMBL
  ENSMUST00000157050 UniProtKB/TrEMBL
  ENSMUST00000202564 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000212819 ENTREZGENE, UniProtKB/TrEMBL
InterPro Paxillin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tgfb1i1/Leupaxin/TGFB1I1 UniProtKB/TrEMBL
  Znf_LIM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:19303 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:108295 ENTREZGENE
NCBI Gene 19303 ENTREZGENE
PANTHER PTHR24216:SF11 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam LIM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pxn PhenoGen
PIRSF Leupaxin UniProtKB/TrEMBL
PROSITE LIM_DOMAIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LIM_DOMAIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART LIM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0J9YTZ8_MOUSE UniProtKB/TrEMBL
  A0A0J9YV30_MOUSE UniProtKB/TrEMBL
  A0A0J9YV66_MOUSE UniProtKB/TrEMBL
  A0A1D5RMM8_MOUSE UniProtKB/TrEMBL
  F8VQ28 ENTREZGENE, UniProtKB/TrEMBL
  PAXI_MOUSE UniProtKB/Swiss-Prot
  Q3UG90_MOUSE UniProtKB/TrEMBL
  Q8VI36 ENTREZGENE
  Q99LE7_MOUSE UniProtKB/TrEMBL
UniProt Secondary Q3TB62 UniProtKB/Swiss-Prot
  Q3TZQ6 UniProtKB/Swiss-Prot
  Q8VI37 UniProtKB/Swiss-Prot