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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10473
Species: Mus musculus
RGD Object: Gene
Symbol: Nqo1
Name: NAD(P)H dehydrogenase, quinone 1
Acc ID: CHEBI:4513
Term: dicoumarol
Definition: A hydroxycoumarin that is methane in which two hydrogens have each been substituted by a 4-hydroxycoumarin-3-yl group. Related to warfarin, it has been used as an anticoagulant.
Chemical ID: MESH:D001728
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nqo1decreases activityEXP 6480464CTDDicumarol results in decreased activity of NQO1 proteinPMID:10092053
Nqo1multiple interactionsEXP 6480464CTD[Dicumarol results in decreased activity of NQO1 protein] which results in decreased abundance of aristolactam I; [Dicumarol results in decreased activity of NQO1 protein] which results in increased abundance of aristolochic acid I; [Dicumarol results in decreased activity of NQO1 protein] which results in increased abundance of aristolochic acid I metabolitePMID:21613233
Nqo1affects response to substanceISONQO1 (Homo sapiens)6480464CTDNQO1 protein affects the susceptibility to DicumarolPMID:10531305
Nqo1decreases activityISONqo1 (Rattus norvegicus)6480464CTDDicumarol results in decreased activity of NQO1 proteinPMID:1379126 PMID:19497421
Nqo1decreases activityISONQO1 (Homo sapiens)6480464CTD[Dicumarol results in decreased activity of NQO1 protein] which results in decreased activity of diaziquone; Dicumarol results in decreased activity of NQO1 proteinPMID:11154737 PMID:15805261 PMID:17669387 PMID:2113030 PMID:33938965 PMID:8572925
Nqo1decreases expressionISONQO1 (Homo sapiens)6480464CTDDicumarol results in decreased expression of NQO1 proteinPMID:17979524
Nqo1multiple interactionsISONqo1 (Rattus norvegicus)6480464CTD[Dicumarol results in decreased activity of NQO1 protein] which results in decreased reduction of Chromium; Dicumarol inhibits the reaction [Benzo(a)pyrene results in increased activity of NQO1 protein]; Dicumarol inhibits the reaction [NQO1 protein inhibits the reaction [Vitamin K 3 results in increased chemical synthesis of Hydrogen Peroxide]]; Dicumarol inhibits the reaction [Progesterone results in increased activity of NQO1 protein]; Dicumarol inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of NQO1 protein]PMID:1379126 PMID:19497421 PMID:21947872 PMID:27558805
Nqo1multiple interactionsISONQO1 (Homo sapiens)6480464CTD[aristolochic acid I co-treated with Dicumarol] results in increased expression of NQO1 protein; [Dicumarol results in decreased activity of NQO1 protein] inhibits the reaction [Eugenol results in increased expression of CD86 protein]; [Dicumarol results in decreased activity of NQO1 protein] which results in decreased susceptibility to Mitomycin; [Dicumarol results in decreased activity of NQO1 protein] which results in decreased susceptibility to Streptonigrin; aristolochic acid I inhibits the reaction [Dicumarol results in decreased activity of NQO1 protein]; Dicumarol inhibits the reaction [[arsenite results in increased expression of NQO1 protein] which results in increased susceptibility to Mitomycin]; Dicumarol inhibits the reaction [NQO1 protein results in decreased susceptibility to arsenite]; Dicumarol inhibits the reaction [NQO1 protein results in increased metabolism of Mitomycin]; Dicumarol inhibits the reaction [NQO1 protein results in increased reduction of 2,6-Dichloroindophenol]; Dicumarol inhibits the reaction [TP53 protein binds to NQO1 protein]; NQO1 protein inhibits the reaction [Dicumarol results in decreased activity of MAPK10 protein]PMID:10531305 PMID:14634213 PMID:15655414 PMID:16494910 PMID:1701346 PMID:21742781 PMID:29281794 PMID:33938965
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