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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:fraxetin
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Accession:CHEBI:5169 term browser browse the term
Definition:A hydroxycoumarin that is 6-methoxycoumarin in which the hydrogens at positions 7 and 8 have been replaced by hydroxy groups.
Synonyms:exact_synonym: 7,8-dihydroxy-6-methoxy-2H-chromen-2-one
 related_synonym: 7,8-dihydroxy-6-methoxy-2-benzopyrone;   7,8-dihydroxy-6-methoxycoumarin;   Formula=C10H8O5;   InChI=1S/C10H8O5/c1-14-6-4-5-2-3-7(11)15-10(5)9(13)8(6)12/h2-4,12-13H,1H3;   InChIKey=HAVWRBANWNTOJX-UHFFFAOYSA-N;   SMILES=C12=C(C=C(OC)C(=C1O)O)C=CC(O2)=O
 xref: CAS:574-84-5;   KEGG:C09265;   KNApSAcK:C00002473;   LINCS:LSM-3712
 xref_mesh: MESH:C105671
 xref: PMID:11456117;   PMID:12860476;   PMID:15120578;   PMID:15904944;   PMID:15996779;   PMID:16394523;   PMID:19721227;   PMID:23788190;   PMID:23806420;   PMID:23994349;   PMID:24025985;   PMID:25189268;   PMID:25445053;   PMID:26945887;   PMID:27722139;   PMID:28976788;   PMID:29157824;   PMID:29344176;   PMID:29414667;   PMID:29559590;   PMID:29581584;   PMID:29786751;   PMID:30205426;   PMID:9120770;   Reaxys:198796;   Wikipedia:Fraxetin



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fraxetin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator decreases expression
increases expression
ISO fraxetin results in decreased expression of BAX protein
Fraxetin increases expression of BAX protein in colorectum
CTD
RGD
PMID:15996779 PMID:32504672 RGD:125097526 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Fraxetin decreases expression of BCL2 protein in colorectum RGD PMID:32504672 RGD:125097526 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Casp3 caspase 3 decreases activity ISO fraxetin results in decreased activity of CASP3 protein CTD PMID:15996779 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp9 caspase 9 decreases activity ISO fraxetin results in decreased activity of CASP9 protein CTD PMID:15996779 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cat catalase multiple interactions ISO fraxetin inhibits the reaction [Rotenone results in increased expression of and results in increased activity of CAT protein] CTD PMID:15904944 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccna2 cyclin A2 decreases expression ISO Fraxetin decreases expression of CCNA2 protein in colorectum RGD PMID:32504672 RGD:125097526 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
JBrowse link
G Ccne1 cyclin E1 decreases expression ISO Fraxetin decreases expression of CCNE1 protein in colorectum RGD PMID:32504672 RGD:125097526 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO Fraxetin decreases expression of CDK2 protein in colorectum RGD PMID:32504672 RGD:125097526 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
JBrowse link
G Cycs cytochrome c, somatic affects localization ISO fraxetin affects the localization of CYCS protein CTD PMID:15996779 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
JBrowse link
G Il6 interleukin 6 multiple interactions ISO fraxetin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL6 mRNA] CTD PMID:30496664 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Jak2 Janus kinase 2 decreases phosphorylation ISO Fraxetin decreases phosphorylation of JAK2 protein in colorectum RGD PMID:32504672 RGD:125097526 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
JBrowse link
G Skp2 S-phase kinase associated protein 2 decreases expression ISO Fraxetin decreases expression of SKP2 mRNA and protein in colorectum RGD PMID:32504672 RGD:125097526 NCBI chr 2:58,161,226...58,189,293
Ensembl chr 2:58,161,229...58,189,338
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO fraxetin inhibits the reaction [Rotenone results in increased expression of and results in increased activity of SOD2 protein] CTD PMID:15904944 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Stat3 signal transducer and activator of transcription 3 decreases phosphorylation ISO Fraxetin decreases phosphorylation of STAT3 protein in colorectum RGD PMID:32504672 RGD:125097526 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO fraxetin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of TNF mRNA] CTD PMID:30496664 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    role 19751
      chemical role 19320
        antioxidant 14438
          fraxetin 15
            fraxin 0
            sideretin (reduced form) + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      carbon group element atom 19619
                        carbon atom 19609
                          organic molecular entity 19609
                            organic molecule 19549
                              organic cyclic compound 19343
                                organic heterocyclic compound 18584
                                  oxacycle 17609
                                    benzopyran 11162
                                      1-benzopyran 10903
                                        chromenes 3026
                                          chromenone 2966
                                            coumarins 2720
                                              hydroxycoumarin 333
                                                fraxetin 15
                                                  fraxin 0
                                                  sideretin (reduced form) + 0
paths to the root