Tnfrsf10b (tumor necrosis factor receptor superfamily, member 10b) - Rat Genome Database

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Gene: Tnfrsf10b (tumor necrosis factor receptor superfamily, member 10b) Mus musculus
Analyze
Symbol: Tnfrsf10b
Name: tumor necrosis factor receptor superfamily, member 10b
RGD ID: 1317581
MGI Page MGI
Description: Predicted to enable TRAIL receptor activity; identical protein binding activity; and protease binding activity. Predicted to be involved in TRAIL-activated apoptotic signaling pathway and positive regulation of apoptotic process. Predicted to act upstream of or within apoptotic process and regulation of apoptotic process. Predicted to be located in Golgi apparatus; cytosol; and membrane raft. Predicted to be active in cell surface and plasma membrane. Is expressed in bladder; liver; renal vasculature; urethra of female; and urethra of male. Human ortholog(s) of this gene implicated in carcinoma (multiple); cervical cancer; hematologic cancer (multiple); and urinary bladder cancer. Orthologous to several human genes including TNFRSF10A (TNF receptor superfamily member 10a) and TNFRSF10B (TNF receptor superfamily member 10b).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: death receptor 5; DR; DR5; KI; Kille; KILLER; KILLER/DR5 TRAIL death-inducing receptor; Ly9; Ly98; MK; TR; TRA; TRAILR2; TRIC; TRICK; TRICK2A; TRICK2B; TRICKB; tumor necrosis factor receptor superfamily member 10B
RGD Orthologs
Human
Rat
Bonobo
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391470,004,921 - 70,021,860 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1470,004,921 - 70,021,860 (+)EnsemblGRCm39 Ensembl
GRCm381469,767,472 - 69,784,411 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1469,767,472 - 69,784,411 (+)EnsemblGRCm38mm10GRCm38
MGSCv371470,167,279 - 70,184,218 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361468,502,609 - 68,519,491 (+)NCBIMGSCv36mm8
Celera1467,301,078 - 67,318,034 (+)NCBICelera
Cytogenetic Map14D2NCBI
cM Map1436.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-tert-butylphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
8-Br-cAMP  (ISO)
9-cis-retinoic acid  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alvocidib  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (EXP,ISO)
atazanavir sulfate  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (ISO)
bortezomib  (ISO)
brefeldin A  (ISO)
Brevetoxin B  (ISO)
bupropion  (ISO)
butanal  (ISO)
Butylparaben  (ISO)
caffeine  (ISO)
cannabidiol  (ISO)
cantharidin  (ISO)
capsaicin  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
celastrol  (ISO)
celecoxib  (ISO)
chenodeoxycholic acid  (ISO)
chlorambucil  (ISO)
chloroquine  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
curcumin  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
daunorubicin  (ISO)
deoxycholic acid  (ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (ISO)
dimethylselenide  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
DuP 697  (ISO)
elemental selenium  (ISO)
embelin  (ISO)
entinostat  (EXP,ISO)
epichlorohydrin  (ISO)
esculetin  (ISO)
ethyl methanesulfonate  (ISO)
fluvastatin  (ISO)
formaldehyde  (ISO)
genistein  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
helenalin  (ISO)
hydroxyl  (ISO)
hydroxyurea  (EXP)
Ilimaquinone  (ISO)
Isoangustone A  (ISO)
Licochalcone B  (ISO)
LY294002  (ISO)
Maduramicin  (EXP)
magnesium oxide  (ISO)
melittin  (ISO)
mercury dibromide  (ISO)
metformin  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
metiram  (ISO)
N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-Nitrosopyrrolidine  (ISO)
nefazodone  (ISO)
nickel atom  (ISO)
Nonidet P-40  (ISO)
NS-398  (ISO)
nystatin  (ISO)
o-anisidine  (ISO)
O-methyleugenol  (ISO)
ouabain  (ISO)
ozone  (ISO)
p-menthan-3-ol  (ISO)
paclitaxel  (ISO)
paraquat  (ISO)
Pendulone  (ISO)
Pentoxifylline  (ISO)
perfluorooctanoic acid  (ISO)
phenethyl caffeate  (ISO)
phenylmercury acetate  (ISO)
propanal  (ISO)
propylparaben  (ISO)
pyrethrins  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
SC-58125  (ISO)
selenium atom  (ISO)
sesquiterpene  (ISO)
sodium arsenate  (ISO)
sulforaphane  (ISO)
sulindac sulfide  (ISO)
sunitinib  (ISO)
temozolomide  (ISO)
thalidomide  (ISO)
thymoquinone  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
Triptolide  (EXP)
troglitazone  (ISO)
valproic acid  (ISO)
vemurafenib  (ISO)
vismodegib  (ISO)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cell surface  (IBA,ISO)
cytosol  (ISO)
Golgi apparatus  (ISO)
membrane  (IEA)
membrane raft  (ISO)
plasma membrane  (IBA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Identification of gene expression profiles correlated to tumor progression in a preclinical model of colon carcinogenesis. Bousserouel S, etal., Int J Oncol. 2010 Jun;36(6):1485-90.
2. Comparative transcriptional and functional profiling of clear cell and papillary renal cell carcinoma. Diegmann J, etal., Int J Mol Med. 2006 Sep;18(3):395-403.
3. Efficacy of anti-death receptor 5 (DR5) antibody (TRA-8) against primary human ovarian carcinoma using a novel ex vivo tissue slice model. Estes JM, etal., Gynecol Oncol. 2007 May;105(2):291-8. Epub 2007 Feb 15.
4. TRAIL signalling: decisions between life and death. Falschlehner C, etal., Int J Biochem Cell Biol. 2007;39(7-8):1462-75. Epub 2007 Feb 14.
5. Frequent polymorphic changes but not mutations of TRAIL receptors DR4 and DR5 in mantle cell lymphoma and other B-cell lymphoid neoplasms. Fernandez V, etal., Haematologica. 2004 Nov;89(11):1322-31.
6. Stimulation of erythropoiesis by thalidomide in multiple myeloma patients: its influence on FasL, TRAIL and their receptors on erythroblasts. Grzasko N, etal., Haematologica. 2006 Mar;91(3):386-9.
7. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
8. TRAIL induces apoptosis of chondrocytes and influences the pathogenesis of experimentally induced rat osteoarthritis. Lee SW, etal., Arthritis Rheum. 2004 Feb;50(2):534-42.
9. [Expression of tumor necrosis factor related apoptosis inducing ligand and its receptor in thymus during early post-burn stage in rat with severe burns] Leng XF, etal., Zhonghua Shao Shang Za Zhi. 2007 Jun;23(3):184-7.
10. Anti-DR5 mAb ameliorate adjuvant arthritis rats through inducing synovial cells apoptosis. Li W, etal., Exp Biol Med (Maywood). 2009 Dec;234(12):1468-76.
11. Evaluating the expression and prognostic value of TRAIL-R1 and TRAIL-R2 in breast cancer. McCarthy MM, etal., Clin Cancer Res. 2005 Jul 15;11(14):5188-94.
12. MGDs mouse GO annotations MGD data from the GO Consortium
13. MGD IEA MGD IEA
14. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
15. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
16. Playing the DISC: turning on TRAIL death receptor-mediated apoptosis in cancer. Pennarun B, etal., Biochim Biophys Acta. 2010 Apr;1805(2):123-40. Epub 2009 Dec 2.
17. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
18. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
19. Comparative analysis of apoptosis and inflammation genes of mice and humans. Reed JC, etal., Genome Res 2003 Jun;13(6B):1376-88.
20. Mouse MP Annotation Import Pipeline RGD automated import pipeline
21. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
23. Anti-tumor activity of TRA-8 anti-death receptor 5 (DR5) monoclonal antibody in combination with chemotherapy and radiation therapy in a cervical cancer model. Straughn JM Jr, etal., Gynecol Oncol. 2006 Apr;101(1):46-54. Epub 2005 Nov 4.
24. Differential apoptosis gene expression in pediatric tumors of the kidney. Takamizawa S, etal., J Pediatr Surg. 2000 Feb;35(2):390-5.
25. Combined natural killer T-cell based immunotherapy eradicates established tumors in mice. Teng MW, etal., Cancer Res. 2007 Aug 1;67(15):7495-504.
26. Genetic expression profiles and chromosomal alterations in sporadic breast cancer in Mexican women. Valladares A, etal., Cancer Genet Cytogenet. 2006 Oct 15;170(2):147-51.
27. Ala228 variant of trail receptor 1 affecting the ligand binding site is associated with chronic lymphocytic leukemia, mantle cell lymphoma, prostate cancer, head and neck squamous cell carcinoma and bladder cancer. Wolf S, etal., Int J Cancer. 2006 Apr 1;118(7):1831-5.
28. Lexatumumab (TRAIL-receptor 2 mAb) induces expression of DR5 and promotes apoptosis in primary and metastatic renal cell carcinoma in a mouse orthotopic model. Zhang L, etal., Cancer Lett. 2007 Jun 18;251(1):146-57. Epub 2006 Dec 20.
Additional References at PubMed
PMID:10349636   PMID:10383128   PMID:10862756   PMID:11042159   PMID:11076861   PMID:11239407   PMID:12477932   PMID:14610273   PMID:14769851   PMID:15044455   PMID:15128592   PMID:15173180  
PMID:15514675   PMID:15589175   PMID:15713653   PMID:16141072   PMID:16141073   PMID:16602821   PMID:17026999   PMID:17041756   PMID:17051329   PMID:17126290   PMID:17617585   PMID:18006832  
PMID:18079962   PMID:18079967   PMID:18192669   PMID:18287559   PMID:18667695   PMID:18776938   PMID:18802095   PMID:19226377   PMID:19273598   PMID:19349211   PMID:20807702   PMID:21040902  
PMID:21169546   PMID:21225479   PMID:21677750   PMID:21768400   PMID:21832159   PMID:21873635   PMID:21938487   PMID:21941003   PMID:22013112   PMID:22789540   PMID:22916132   PMID:23071253  
PMID:23347256   PMID:23430714   PMID:23605004   PMID:23676461   PMID:23815209   PMID:24117005   PMID:24466325   PMID:24695582   PMID:24971483   PMID:24994655   PMID:25843002   PMID:26383973  
PMID:26609054   PMID:26791792   PMID:26982364   PMID:26991125   PMID:28055006   PMID:28444885   PMID:29403497   PMID:29436413   PMID:30254289   PMID:30423122   PMID:30635284   PMID:30850660  
PMID:30858352   PMID:30988397   PMID:31473246   PMID:33323382   PMID:33875613   PMID:34223817   PMID:35264458   PMID:36232931   PMID:36791922   PMID:37460623   PMID:38199990  


Genomics

Comparative Map Data
Tnfrsf10b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391470,004,921 - 70,021,860 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1470,004,921 - 70,021,860 (+)EnsemblGRCm39 Ensembl
GRCm381469,767,472 - 69,784,411 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1469,767,472 - 69,784,411 (+)EnsemblGRCm38mm10GRCm38
MGSCv371470,167,279 - 70,184,218 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361468,502,609 - 68,519,491 (+)NCBIMGSCv36mm8
Celera1467,301,078 - 67,318,034 (+)NCBICelera
Cytogenetic Map14D2NCBI
cM Map1436.1NCBI
TNFRSF10A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38823,190,452 - 23,225,102 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl823,190,452 - 23,225,102 (-)EnsemblGRCh38hg38GRCh38
GRCh37823,047,965 - 23,082,615 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36823,104,915 - 23,138,584 (-)NCBINCBI36Build 36hg18NCBI36
Build 34823,104,915 - 23,138,584NCBI
Celera822,011,569 - 22,045,255 (-)NCBICelera
Cytogenetic Map8p21.3NCBI
HuRef821,594,946 - 21,628,637 (-)NCBIHuRef
CHM1_1823,251,086 - 23,284,807 (-)NCBICHM1_1
T2T-CHM13v2.0823,465,337 - 23,499,970 (-)NCBIT2T-CHM13v2.0
Tnfrsf10b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81551,249,883 - 51,278,091 (+)NCBIGRCr8
mRatBN7.21544,840,386 - 44,868,318 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1544,840,386 - 44,867,467 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1548,958,259 - 48,986,200 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01550,069,754 - 50,097,693 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01546,929,101 - 46,957,032 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01551,433,853 - 51,464,215 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01555,161,595 - 55,192,095 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41550,138,439 - 50,163,254 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11550,155,031 - 50,177,989 (+)NCBI
Celera1544,522,716 - 44,548,374 (+)NCBICelera
Cytogenetic Map15p11NCBI
TNFRSF10A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2741,692,326 - 41,732,181 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1817,422,892 - 17,459,408 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0822,440,502 - 22,476,790 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1819,378,547 - 19,414,724 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl819,378,547 - 19,414,724 (-)Ensemblpanpan1.1panPan2
LOC100737977
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1147,344,788 - 7,371,086 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2147,869,520 - 7,886,618 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TNFRSF10A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1821,318,987 - 21,351,641 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl821,315,149 - 21,351,673 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605220,871,352 - 20,907,523 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Tnfrsf10b
470 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:620
Count of miRNA genes:421
Interacting mature miRNAs:481
Transcripts:ENSMUST00000022663
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357589Kdnw2_mkidney weight 2 (mouse)Not determined1420887473121269804Mouse
1357527Epfpq1_mepididymal fat percentage QTL 1 (mouse)Not determined142106245071885801Mouse
27226774Tibl15_mtibia length 15, 10 week (mouse)143032195787937436Mouse
10043887Cia50_mcollagen induced arthritis QTL 50 (mouse)Not determined143743018571430320Mouse
4142419Tgq26_mtriglyceride QTL 26 (mouse)Not determined4033731974337319Mouse
1301777Bglq15_mbody growth late QTL 15 (mouse)Not determined144296241676962593Mouse
1301424Skull21_mskull morphology 21 (mouse)Not determined144296241676962593Mouse
1300805Mors3_mmodifier of obesity related sterility 3 (mouse)Not determined144303727077037418Mouse
1301091Bbaa21_mB.burgdorferi-associated arthritis 21 (mouse)Not determined144306584777066045Mouse
4141400Nilac8_mnicotine induced locomotor activity 8 (mouse)Not determined144306584777066045Mouse
1300605El5_mepilepsy 5 (mouse)Not determined144945542583455556Mouse
4142364Pbwg18_mpostnatal body weight growth 18 (mouse)Not determined145228198486282125Mouse
1301489Lbm10_mlean body mass 10 (mouse)Not determined145376129687761529Mouse
12880432Fgf23lq3_mFGF23 serum level QTL 3 (mouse)145393744087937440Mouse
10043889Cia52_mcollagen induced arthritis QTL 52 (mouse)Not determined145608238190082509Mouse
1301562Hwq1_mheart weight quantitative locus 1 (mouse)Not determined145654674590546941Mouse
1357565wrmod1_mwobbler modifier 1 (mouse)Not determined1458179640101859473Mouse
11039527Ccc2_mcolitis susceptibility in the Collaborative Cross 2 (mouse)145991861294138217Mouse
1300666Fembm2_mfemoral bone morphometry 2 (mouse)Not determined146239746096397680Mouse

Markers in Region
px-31f3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11B5UniSTS
Cytogenetic Map7A1UniSTS
Cytogenetic Map16C3.3UniSTS
Cytogenetic Map10A4UniSTS
Cytogenetic Map10A3-A4UniSTS
Cytogenetic Map18B3UniSTS
Cytogenetic Map7CUniSTS
Cytogenetic Map9E3.1UniSTS
Cytogenetic Map10A1UniSTS
Cytogenetic Map17CUniSTS
Cytogenetic Map15F1UniSTS
Cytogenetic Map7F3UniSTS
Cytogenetic Map16B5UniSTS
Cytogenetic Map15D3UniSTS
Cytogenetic Map7F1UniSTS
Cytogenetic Map10C3UniSTS
Cytogenetic Map3F1UniSTS
Cytogenetic Map14BUniSTS
Cytogenetic Map5C3.1UniSTS
Cytogenetic Map10B5.1UniSTS
Cytogenetic Map18E4UniSTS
Cytogenetic Map1A2UniSTS
Cytogenetic Map18D1UniSTS
Cytogenetic Map8A2UniSTS
Cytogenetic Map5A3UniSTS
Cytogenetic Map2A3UniSTS
Cytogenetic Map14D2UniSTS
Cytogenetic Map3F2.2UniSTS
Cytogenetic Map13C1UniSTS
Cytogenetic Map5G2UniSTS
Cytogenetic Map10C1UniSTS
Cytogenetic Map11CUniSTS
Cytogenetic Map17B3UniSTS
Cytogenetic Map12C2UniSTS
Cytogenetic Map13B2UniSTS
Cytogenetic Map15A1UniSTS
Cytogenetic Map11E1UniSTS
Cytogenetic Map5B1UniSTS
Cytogenetic Map10D1UniSTS
Cytogenetic Map13D1UniSTS
Cytogenetic Map4C3UniSTS
Cytogenetic MapXDUniSTS
Cytogenetic Map18D3UniSTS
cM Map1060.0UniSTS
cM Map154.6UniSTS
cM Map439.4UniSTS
cM Map1170.0UniSTS
cM Map1336.0UniSTS
cM Map518.2UniSTS
cM Map1229.0UniSTS
cM MapX42.0UniSTS
cM Map1347.01UniSTS
D10Mit157.2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6D1UniSTS
Cytogenetic Map16B4UniSTS
Cytogenetic Map18E2UniSTS
Cytogenetic Map4C3UniSTS
Cytogenetic Map7B2UniSTS
Cytogenetic Map4D2.3UniSTS
Cytogenetic Map11E1UniSTS
Cytogenetic Map14E2.2UniSTS
Cytogenetic Map4C7UniSTS
Cytogenetic Map2H4UniSTS
Cytogenetic Map1FUniSTS
Cytogenetic Map6C3UniSTS
Cytogenetic Map11DUniSTS
Cytogenetic Map3G2UniSTS
Cytogenetic Map17A1UniSTS
Cytogenetic Map9F2UniSTS
Cytogenetic Map12F1UniSTS
Cytogenetic Map19C2UniSTS
Cytogenetic Map3BUniSTS
Cytogenetic Map8C1UniSTS
Cytogenetic Map18A2UniSTS
Cytogenetic Map3F2UniSTS
Cytogenetic Map14C3UniSTS
Cytogenetic Map8E1UniSTS
Cytogenetic Map8E2UniSTS
Cytogenetic Map5B1UniSTS
Cytogenetic Map18B1UniSTS
Cytogenetic Map9CUniSTS
Cytogenetic Map14C2UniSTS
Cytogenetic Map6A1UniSTS
Cytogenetic Map10B4UniSTS
Cytogenetic Map13D2.1UniSTS
Cytogenetic Map5E5UniSTS
Cytogenetic Map11B1.3UniSTS
Cytogenetic Map4D1UniSTS
Cytogenetic Map9A5.2UniSTS
Cytogenetic Map3F1UniSTS
Cytogenetic Map17E3UniSTS
Cytogenetic Map11B3UniSTS
Cytogenetic Map1H4UniSTS
Cytogenetic Map6A3UniSTS
Cytogenetic Map5E4-E5UniSTS
Cytogenetic Map15E1UniSTS
Cytogenetic Map13DUniSTS
Cytogenetic Map14BUniSTS
Cytogenetic Map14D1UniSTS
Cytogenetic Map7B4UniSTS
Cytogenetic Map8D3UniSTS
Cytogenetic MapXDUniSTS
Cytogenetic Map17A3.3UniSTS
Cytogenetic Map7E2UniSTS
Cytogenetic Map1H2.3UniSTS
Cytogenetic Map7A2UniSTS
Cytogenetic Map7F3UniSTS
Cytogenetic Map9F1UniSTS
Cytogenetic Map10C1UniSTS
Cytogenetic Map4E2UniSTS
Cytogenetic Map16A1UniSTS
Cytogenetic Map8B3.3UniSTS
Cytogenetic Map8D2UniSTS
Cytogenetic Map3DUniSTS
Cytogenetic Map15D2UniSTS
Cytogenetic Map17B1UniSTS
Cytogenetic Map7A3UniSTS
Cytogenetic Map15F1UniSTS
Cytogenetic Map16B2UniSTS
Cytogenetic Map7CUniSTS
Cytogenetic Map3F2.1UniSTS
Cytogenetic Map6F3UniSTS
Cytogenetic Map1C4UniSTS
Cytogenetic Map11E2UniSTS
Cytogenetic Map11B5UniSTS
Cytogenetic Map9F3UniSTS
Cytogenetic Map2BUniSTS
Cytogenetic Map13B3UniSTS
Cytogenetic Map9A4UniSTS
Cytogenetic Map5A3UniSTS
Cytogenetic Map2H1UniSTS
Cytogenetic Map16B1UniSTS
Cytogenetic Map1A5UniSTS
Cytogenetic Map11CUniSTS
Cytogenetic Map9E1UniSTS
Cytogenetic Map6G1UniSTS
Cytogenetic MapXA2UniSTS
Cytogenetic Map13B1UniSTS
Cytogenetic Map5E2UniSTS
Cytogenetic Map12C1UniSTS
Cytogenetic Map5FUniSTS
Cytogenetic Map4D3UniSTS
Cytogenetic Map10C2UniSTS
Cytogenetic Map9BUniSTS
Cytogenetic Map5G2UniSTS
Cytogenetic Map7F1UniSTS
Cytogenetic Map12C3UniSTS
Cytogenetic Map10A4UniSTS
Cytogenetic Map8A2UniSTS
Cytogenetic Map18A1UniSTS
Cytogenetic Map12A1.1UniSTS
Cytogenetic Map1C2UniSTS
Cytogenetic Map11B2UniSTS
Cytogenetic Map6E3UniSTS
Cytogenetic Map5C3.3UniSTS
Cytogenetic Map1BUniSTS
Cytogenetic Map17A3.1UniSTS
Cytogenetic Map7A1UniSTS
Cytogenetic Map2E5UniSTS
Cytogenetic Map11A1UniSTS
Cytogenetic Map4B1UniSTS
Cytogenetic Map15A2UniSTS
Cytogenetic Map8C3UniSTS
Cytogenetic Map2A3UniSTS
Cytogenetic Map5G3UniSTS
Cytogenetic Map4A3UniSTS
Cytogenetic Map2H3UniSTS
Cytogenetic Map8A1UniSTS
Cytogenetic Map8A1.1UniSTS
Cytogenetic Map16A3UniSTS
Cytogenetic Map10B1UniSTS
Cytogenetic Map19AUniSTS
Cytogenetic Map10A1UniSTS
Cytogenetic Map13D1UniSTS
Cytogenetic Map4A1UniSTS
Cytogenetic Map9A3UniSTS
Cytogenetic Map17CUniSTS
Cytogenetic Map1DUniSTS
Cytogenetic Map5E3UniSTS
Cytogenetic Map15D3UniSTS
Cytogenetic Map2H2UniSTS
Cytogenetic Map7D3UniSTS
Cytogenetic Map2A1UniSTS
Cytogenetic Map14C1UniSTS
Cytogenetic Map14E5UniSTS
Cytogenetic Map10CUniSTS
Cytogenetic Map18B2UniSTS
Cytogenetic Map2F1UniSTS
Cytogenetic Map10D3UniSTS
Cytogenetic Map17A2UniSTS
Cytogenetic Map2C3UniSTS
Cytogenetic Map1C3UniSTS
Cytogenetic Map17B2UniSTS
Cytogenetic Map5B2UniSTS
Cytogenetic Map5G1UniSTS
Cytogenetic Map4C6UniSTS
Cytogenetic Map13C3UniSTS
Cytogenetic Map2E1UniSTS
Cytogenetic Map17A3.2-A3.3UniSTS
Cytogenetic Map19C3UniSTS
Cytogenetic Map7E3UniSTS
Cytogenetic Map13C1UniSTS
Cytogenetic Map9E3.1UniSTS
Cytogenetic Map15E3UniSTS
Cytogenetic Map6B1UniSTS
Cytogenetic MapXE3UniSTS
Cytogenetic Map4C4UniSTS
Cytogenetic Map3E3UniSTS
Cytogenetic Map11A4UniSTS
Cytogenetic Map4C5UniSTS
Cytogenetic Map18B3UniSTS
Cytogenetic Map9A2UniSTS
Cytogenetic Map7E1UniSTS
Cytogenetic Map5D-E1UniSTS
Cytogenetic Map5B3UniSTS
Cytogenetic Map13A2-A3UniSTS
Cytogenetic Map5A2UniSTS
Cytogenetic Map4B3UniSTS
Cytogenetic Map1E4UniSTS
Cytogenetic Map17E4UniSTS
Cytogenetic Map1G2UniSTS
Cytogenetic Map15B3.1UniSTS
Cytogenetic Map12EUniSTS
Cytogenetic MapXA5UniSTS
Cytogenetic Map6A3.3UniSTS
Cytogenetic Map6G3UniSTS
Cytogenetic Map6F2UniSTS
Cytogenetic Map5C1UniSTS
Cytogenetic Map4D2.1UniSTS
Cytogenetic Map4A5UniSTS
Cytogenetic Map3F2.2UniSTS
Cytogenetic Map1E3-E4UniSTS
Cytogenetic Map9F1-F3UniSTS
Cytogenetic Map1C1.1UniSTS
Cytogenetic Map14D2UniSTS
Cytogenetic Map12A2UniSTS
Cytogenetic Map17A3-BUniSTS
Cytogenetic Map7F5UniSTS
Cytogenetic Map14A3UniSTS
Cytogenetic Map5G1.1UniSTS
Cytogenetic MapXF2-F4UniSTS
Cytogenetic Map7D2UniSTS
Cytogenetic Map2F3UniSTS
Cytogenetic Map10A3UniSTS
Cytogenetic MapXA7.3UniSTS
Cytogenetic Map9F1-F2UniSTS
Cytogenetic Map13A3.2UniSTS
Cytogenetic Map10A2UniSTS
Cytogenetic Map1C1UniSTS
Cytogenetic Map1A1UniSTS
Cytogenetic Map12D3UniSTS
Cytogenetic Map1A3-A5UniSTS
Cytogenetic Map2A2UniSTS
Cytogenetic Map3A1UniSTS
Cytogenetic MapXA3.3UniSTS
Cytogenetic Map16A-B1UniSTS
Cytogenetic Map1D2.3UniSTS
Cytogenetic Map6B2.3UniSTS
Cytogenetic Map2G3UniSTS
Cytogenetic MapXA2-A3.1UniSTS
Cytogenetic Map9A5.3UniSTS
Cytogenetic Map14A2-BUniSTS
Cytogenetic Map8E1-E2UniSTS
Cytogenetic Map8A3UniSTS
Cytogenetic Map1G3-H1UniSTS
Cytogenetic Map8B3-C1UniSTS
Cytogenetic Map19C1UniSTS
Cytogenetic Map8C5UniSTS
Cytogenetic Map8A4UniSTS
Cytogenetic Map15F3UniSTS
Cytogenetic Map14E4UniSTS
Cytogenetic Map4D2.2UniSTS
Cytogenetic MapXF5UniSTS
cM Map1040.0UniSTS
Whitehead Genetic1033.9UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000022663   ⟹   ENSMUSP00000022663
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1470,004,921 - 70,021,860 (+)Ensembl
GRCm38.p6 Ensembl1469,767,472 - 69,784,411 (+)Ensembl
RefSeq Acc Id: ENSMUST00000224235
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1470,014,918 - 70,020,123 (+)Ensembl
GRCm38.p6 Ensembl1469,777,469 - 69,782,674 (+)Ensembl
RefSeq Acc Id: ENSMUST00000224533
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1470,004,934 - 70,017,135 (+)Ensembl
GRCm38.p6 Ensembl1469,767,485 - 69,779,686 (+)Ensembl
RefSeq Acc Id: NM_020275   ⟹   NP_064671
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391470,004,921 - 70,021,860 (+)NCBI
GRCm381469,767,472 - 69,784,411 (+)ENTREZGENE
MGSCv371470,167,279 - 70,184,218 (+)RGD
Celera1467,301,078 - 67,318,034 (+)RGD
cM Map14 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_036158575   ⟹   XP_036014468
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391470,004,926 - 70,021,860 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_064671   ⟸   NM_020275
- Peptide Label: precursor
- UniProtKB: Q9JJL5 (UniProtKB/Swiss-Prot),   Q6GSD9 (UniProtKB/Swiss-Prot),   Q9JJL6 (UniProtKB/Swiss-Prot),   Q9QZM4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000022663   ⟸   ENSMUST00000022663
RefSeq Acc Id: XP_036014468   ⟸   XM_036158575
- Peptide Label: isoform X1
Protein Domains
Death

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9QZM4-F1-model_v2 AlphaFold Q9QZM4 1-381 view protein structure

Promoters
RGD ID:8682870
Promoter ID:EPDNEW_M19466
Type:initiation region
Name:Tnfrsf10b_1
Description:Mus musculus tumor necrosis factor receptor superfamily, member10b , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381469,767,520 - 69,767,580EPDNEW
RGD ID:6825491
Promoter ID:MM_KWN:17347
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   ES_Cell,   MEF_B4,   MEF_B6
Transcripts:NM_020275_TNFRSF10B,   UC007UMU.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361470,167,156 - 70,167,656 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1341090 AgrOrtholog
Ensembl Genes ENSMUSG00000022074 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000022663 ENTREZGENE
  ENSMUST00000022663.7 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.533.10 UniProtKB/Swiss-Prot
  Tumor Necrosis Factor Receptor, subunit A, domain 2 UniProtKB/Swiss-Prot
InterPro DEATH-like_dom_sf UniProtKB/Swiss-Prot
  Death_domain UniProtKB/Swiss-Prot
  TNFR/NGFR_Cys_rich_reg UniProtKB/Swiss-Prot
  TNFR_10 UniProtKB/Swiss-Prot
  TNFRSF10_N UniProtKB/Swiss-Prot
  TNFRSF10A/B_death UniProtKB/Swiss-Prot
KEGG Report mmu:21933 UniProtKB/Swiss-Prot
MGD MGI:1341090 ENTREZGENE
NCBI Gene 21933 ENTREZGENE
PANTHER TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 10A UniProtKB/Swiss-Prot
  TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 10B UniProtKB/Swiss-Prot
Pfam Death UniProtKB/Swiss-Prot
  TNFR_c6 UniProtKB/Swiss-Prot
PhenoGen Tnfrsf10b PhenoGen
PIRSF CD261_antigen UniProtKB/Swiss-Prot
PRINTS TNFACTORR10 UniProtKB/Swiss-Prot
PROSITE DEATH_DOMAIN UniProtKB/Swiss-Prot
  TNFR_NGFR_1 UniProtKB/Swiss-Prot
  TNFR_NGFR_2 UniProtKB/Swiss-Prot
SMART DEATH UniProtKB/Swiss-Prot
  TNFR UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47986 UniProtKB/Swiss-Prot
  TNF receptor-like UniProtKB/Swiss-Prot
UniProt Q6GSD9 ENTREZGENE
  Q9JJL5 ENTREZGENE
  Q9JJL6 ENTREZGENE
  Q9QZM4 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q6GSD9 UniProtKB/Swiss-Prot
  Q9JJL5 UniProtKB/Swiss-Prot
  Q9JJL6 UniProtKB/Swiss-Prot