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ONTOLOGY REPORT - ANNOTATIONS


Term:dicoumarol
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Accession:CHEBI:4513 term browser browse the term
Definition:A hydroxycoumarin that is methane in which two hydrogens have each been substituted by a 4-hydroxycoumarin-3-yl group. Related to warfarin, it has been used as an anticoagulant.
Synonyms:exact_synonym: 3,3'-methanediylbis(4-hydroxy-2H-chromen-2-one)
 related_synonym: 3,3'-methylen-bis(4-hydroxy-cumarin);   3,3'-methylene-bis(4-hydroxycoumarine);   3,3'-methylenebis(4-hydroxy-1,2-benzopyrone);   3,3'-methylenebis(4-hydroxy-2H-1-benzopyran-2-one);   3,3'-methylenebis(4-hydroxycoumarin);   Formula=C19H12O6;   InChI=1S/C19H12O6/c20-16-10-5-1-3-7-14(10)24-18(22)12(16)9-13-17(21)11-6-2-4-8-15(11)25-19(13)23/h1-8,20-21H,9H2;   InChIKey=DOBMPNYZJYQDGZ-UHFFFAOYSA-N;   SMILES=Oc1c(Cc2c(O)c3ccccc3oc2=O)c(=O)oc2ccccc12;   bis(4-hydroxycoumarin-3-yl)methane;   bis-3,3'-(4-hydroxycoumarinyl)methane;   bis-hydroxycoumarin;   di-(4-hydroxy-3-coumarinyl)methane;   dicoumarolum;   dicumarol
 alt_id: CHEBI:469386
 xref: Beilstein:335444 "Beilstein";   CAS:66-76-2 "ChemIDplus";   CAS:66-76-2 "KEGG COMPOUND";   CAS:66-76-2 "NIST Chemistry WebBook";   DrugBank:DB00266;   Drug_Central:867 "DrugCentral";   KEGG:C00796;   KEGG:D03798;   KNApSAcK:C00002467;   LINCS:LSM-5884
 xref_mesh: MESH:D001728
 xref: PMID:15639223 "Europe PMC";   PMID:16700548 "Europe PMC";   PMID:18347135 "Europe PMC";   PMID:19583730 "Europe PMC";   PMID:20480521 "Europe PMC";   PMID:28166217 "Europe PMC";   PMID:6033758 "Europe PMC";   Wikipedia:Dicumarol


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dicoumarol term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akr1c1 aldo-keto reductase family 1, member C1 JBrowse link 17 69,441,253 69,460,334 RGD:6480464
G Alb albumin JBrowse link 14 19,176,275 19,191,793 RGD:6480464
G Atm ATM serine/threonine kinase JBrowse link 8 58,015,938 58,119,973 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Cat catalase JBrowse link 3 93,379,872 93,412,058 RGD:6480464
G Cd86 CD86 molecule JBrowse link 11 67,060,305 67,117,990 RGD:6480464
G Cdkn1a cyclin-dependent kinase inhibitor 1A JBrowse link 20 6,348,422 6,358,864 RGD:6480464
G Cycs cytochrome c, somatic JBrowse link 4 80,331,226 80,333,326 RGD:6480464
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 JBrowse link 1 213,511,892 213,522,195 RGD:6480464
G Drd5 dopamine receptor D5 JBrowse link 14 77,220,579 77,222,006 RGD:6480464
G Hspa5 heat shock protein family A (Hsp70) member 5 JBrowse link 3 13,838,304 13,842,763 RGD:6480464
G Igf1 insulin-like growth factor 1 JBrowse link 7 28,412,123 28,491,815 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6480464
G Jun Jun proto-oncogene, AP-1 transcription factor subunit JBrowse link 5 114,011,184 114,014,277 RGD:6480464
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6480464
G Mapk10 mitogen activated protein kinase 10 JBrowse link 14 8,079,955 8,371,508 RGD:6480464
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6480464
G Mapk8 mitogen-activated protein kinase 8 JBrowse link 16 9,620,854 9,709,342 RGD:6480464
G Mapk9 mitogen-activated protein kinase 9 JBrowse link 10 35,333,859 35,374,364 RGD:6480464
G Mmp9 matrix metallopeptidase 9 JBrowse link 3 161,413,410 161,421,473 RGD:6480464
G Mt1 metallothionein 1 JBrowse link 19 11,301,991 11,303,007 RGD:6480464
G Nfkb1 nuclear factor kappa B subunit 1 JBrowse link 2 240,773,520 240,890,053 RGD:6480464
G Nqo1 NAD(P)H quinone dehydrogenase 1 JBrowse link 19 38,422,210 38,437,103 RGD:6480464
G Rb1 RB transcriptional corepressor 1 JBrowse link 15 55,081,582 55,209,060 RGD:6480464
G Rb1cc1 RB1-inducible coiled-coil 1 JBrowse link 5 13,033,918 13,097,369 RGD:6480464
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:6480464
G Slc30a1 solute carrier family 30 member 1 JBrowse link 13 110,677,810 110,681,683 RGD:6480464
G Sod1 superoxide dismutase 1 JBrowse link 11 30,363,282 30,368,858 RGD:6480464
G Sod2 superoxide dismutase 2 JBrowse link 1 47,914,757 47,921,587 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:6480464
G Traf2 Tnf receptor-associated factor 2 JBrowse link 3 2,746,061 2,770,690 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19679
    role 19623
      biological role 19621
        pharmacological role 18695
          antagonist 15808
            vitamin K antagonist 197
              dicoumarol 32
Path 2
Term Annotations click to browse term
  CHEBI ontology 19679
    subatomic particle 19675
      composite particle 19675
        hadron 19675
          baryon 19675
            nucleon 19675
              atomic nucleus 19675
                atom 19675
                  main group element atom 19555
                    p-block element atom 19555
                      carbon group element atom 19438
                        carbon atom 19430
                          organic molecular entity 19430
                            organic molecule 19353
                              organic cyclic compound 19102
                                organic heterocyclic compound 18170
                                  oxacycle 16959
                                    benzopyran 9469
                                      1-benzopyran 9164
                                        chromenes 895
                                          chromenone 818
                                            coumarins 534
                                              hydroxycoumarin 289
                                                dicoumarol 32
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.