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Gene: Skp2 (S-phase kinase-associated protein 2 (p45)) Mus musculus
Symbol: Skp2
Name: S-phase kinase-associated protein 2 (p45)
Description: Contributes to ubiquitin protein ligase activity. Involved in several processes, including cellular protein metabolic process; mitotic cell cycle phase transition; and positive regulation of intracellular estrogen receptor signaling pathway. Localizes to the SCF ubiquitin ligase complex. Human ortholog(s) of this gene implicated in prostate carcinoma. Is expressed in several structures, including blastocyst; compacted morula; and retina nuclear layer. Orthologous to human SKP2 (S-phase kinase associated protein 2); PARTICIPATES IN Notch signaling pathway; p53 signaling pathway; cell cycle pathway, mitotic; INTERACTS WITH 1-chloro-2,4-dinitrobenzene; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 4930500A04Rik; cyclin A/CDK2-associated protein p45; cyclin-A/CDK2-associated protein p45; F-box protein Skp2; F-box/WD-40 protein 1; FBXL1; FWD1; hypothetical protein LOC75034; MGC102075; MGC116668; p45; RIKEN cDNA 4930500A04 gene; S-phase kinase-associated protein 2; uncharacterized protein LOC75034
Homo sapiens (human) : SKP2 (S-phase kinase associated protein 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Skp2 (S-phase kinase associated protein 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Skp2 (S-phase kinase associated protein 2)
Pan paniscus (bonobo/pygmy chimpanzee) : SKP2 (S-phase kinase associated protein 2)
Canis lupus familiaris (dog) : SKP2 (S-phase kinase associated protein 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Skp2 (S-phase kinase associated protein 2)
Sus scrofa (pig) : SKP2 (S-phase kinase associated protein 2)
Chlorocebus sabaeus (green monkey) : SKP2 (S-phase kinase associated protein 2)
Heterocephalus glaber (naked mole-rat) : Skp2 (S-phase kinase associated protein 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl159,111,985 - 9,155,425 (-)Ensembl
GRCm38159,111,982 - 9,155,425 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37159,041,742 - 9,070,207 (-)NCBIGRCm37mm9NCBIm37
MGSCv36159,038,867 - 9,067,333 (-)NCBImm8
Celera158,929,100 - 8,972,910 (-)NCBICelera
Cytogenetic Map15 A1NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Skp2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1552631
Created: 2005-09-30
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.