Reg3b (regenerating islet-derived 3 beta) - Rat Genome Database
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Reg3b (regenerating islet-derived 3 beta) Mus musculus
Analyze
Symbol: Reg3b
Name: regenerating islet-derived 3 beta
RGD ID: 11057
MGI Page MGI
Description: Is expressed in central nervous system; dorsal root ganglion; hypoglossal nerve; and intestine. Orthologous to several human genes including REG3A (regenerating family member 3 alpha); INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; 2,4,6-trinitrobenzenesulfonic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: HIP; P; pancreatitis-associated protein 1; Pap; PAP1; REG; reg III-beta; REG-3-beta; REG-III; regenerating islet-derived protein 3-beta; regenerating islet-derived protein III-beta; RegIII (beta)
RGD Orthologs
Human
Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39678,347,868 - 78,350,449 (+)NCBIGRCm39mm39
GRCm39 Ensembl678,347,640 - 78,350,449 (+)Ensembl
GRCm38678,370,885 - 78,373,466 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl678,370,657 - 78,373,466 (+)EnsemblGRCm38mm10GRCm38
MGSCv37678,320,879 - 78,323,460 (+)NCBIGRCm37mm9NCBIm37
MGSCv36678,300,394 - 78,302,975 (+)NCBImm8
Celera680,394,075 - 80,396,656 (+)NCBICelera
Cytogenetic Map6C3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
1. Ampo K, etal., J Neurotrauma. 2009 Oct;26(10):1683-93. doi: 10.1089/neu.2008-0847.
2. Calderari S, etal., PLoS One. 2014 Feb 26;9(2):e90045. doi: 10.1371/journal.pone.0090045. eCollection 2014.
3. Christa L, etal., Am J Pathol. 1999 Nov;155(5):1525-33.
4. Folch-Puy E, etal., J Pathol. 2003 Mar;199(3):398-408.
5. Kawahara S, etal., Neuroscience. 2011 Feb 23;175:273-80. doi: 10.1016/j.neuroscience.2010.11.020. Epub 2010 Nov 18.
6. Keim V, etal., Pancreas. 1994 Sep;9(5):606-12.
7. LaCroix-Fralish ML, etal., Pain. 2011 Aug;152(8):1888-98. doi: 10.1016/j.pain.2011.04.014. Epub 2011 May 10.
8. Lin YY, etal., Pancreas. 2008 May;36(4):402-10. doi: 10.1097/MPA.0b013e31815f3933.
9. Meili S, etal., Cell Tissue Res. 2003 Jun;312(3):291-9. Epub 2003 May 23.
10. MGD and Homologene mouse data transfer
11. MGD data from the GO Consortium
12. Namikawa K, etal., Biochem Biophys Res Commun. 2005 Jun 24;332(1):126-34.
13. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
14. Pin CL, etal., J Cell Biol 2001 Nov 12;155(4):519-30. Epub 2001 Nov 5.
15. RGD automated import pipeline
16. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. RGD automated import pipeline for gene-chemical interactions
18. Su SB, etal., Pancreas. 1999 Oct;19(3):239-47.
19. Watanabe R, etal., Transl Res. 2008 Sep;152(3):119-27. doi: 10.1016/j.trsl.2008.07.006. Epub 2008 Aug 20.
20. Xiong X, etal., Am J Physiol Endocrinol Metab. 2011 Apr;300(4):E669-80. doi: 10.1152/ajpendo.00600.2010. Epub 2011 Jan 18.
21. Zenilman ME, etal., Ann Surg. 2000 Nov;232(5):646-52.
Additional References at PubMed
PMID:7679928   PMID:8076648   PMID:8795446   PMID:9055810   PMID:10329612   PMID:10767532   PMID:12477932   PMID:14660681   PMID:15489334   PMID:16971476   PMID:18678917   PMID:20562862  
PMID:21187123   PMID:21267068   PMID:21410322   PMID:21681751   PMID:21694778   PMID:21873635   PMID:22252863   PMID:22723890   PMID:22745161   PMID:23012479   PMID:23064197   PMID:23147030  
PMID:23811004   PMID:23867474   PMID:25751817   PMID:26404002   PMID:26867181   PMID:28071719   PMID:28190640   PMID:28415799   PMID:28780076   PMID:29249464   PMID:29544958   PMID:29850784  
PMID:30926747   PMID:31132747   PMID:32560820  


Genomics

Comparative Map Data
Reg3b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39678,347,868 - 78,350,449 (+)NCBIGRCm39mm39
GRCm39 Ensembl678,347,640 - 78,350,449 (+)Ensembl
GRCm38678,370,885 - 78,373,466 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl678,370,657 - 78,373,466 (+)EnsemblGRCm38mm10GRCm38
MGSCv37678,320,879 - 78,323,460 (+)NCBIGRCm37mm9NCBIm37
MGSCv36678,300,394 - 78,302,975 (+)NCBImm8
Celera680,394,075 - 80,396,656 (+)NCBICelera
Cytogenetic Map6C3NCBI
REG3A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl279,157,003 - 79,159,753 (-)EnsemblGRCh38hg38GRCh38
GRCh38279,157,006 - 79,159,753 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37279,384,132 - 79,386,879 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36279,237,641 - 79,240,387 (-)NCBINCBI36hg18NCBI36
Celera279,212,862 - 79,215,608 (-)NCBI
Cytogenetic Map2p12NCBI
HuRef279,119,456 - 79,122,204 (-)NCBIHuRef
CHM1_1279,313,660 - 79,316,408 (-)NCBICHM1_1
Reg3b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24110,861,775 - 110,865,015 (+)NCBI
Rnor_6.0 Ensembl4109,467,272 - 109,470,510 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.04109,467,272 - 109,470,510 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04174,173,099 - 174,176,337 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44112,355,773 - 112,359,011 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14112,600,253 - 112,603,492 (+)NCBI
Celera499,893,732 - 99,896,970 (+)NCBICelera
Cytogenetic Map4q33NCBI


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25440480Moaq2_mmodifier of alien QTL 2 (mouse)61117500000Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139100000Mouse
1300556Cia6_mcollagen induced arthritis QTL 6 (mouse)Not determined6446488487426034Mouse
4142126W3q3_mweight 3 weeks QTL 3 (mouse)Not determined450382396656149Mouse
4142361W10q11_mweight 10 weeks QTL 11 (mouse)Not determined450382396656149Mouse
4142271Egq8_mearly growth QTL 8 (mouse)Not determined450382396656149Mouse
4142232W6q4_mweight 6 weeks QTL 4 (mouse)Not determined450382396656149Mouse
26884441Sklq3_mskull length QTL 3, 5 week (mouse)6760000080600000Mouse
13208564Bmiq7_mbody mass index QTL 7 (mouse)62500000080000000Mouse
1558984Cplaq9_mcircadian period of locomotor activity 9 (mouse)Not determined63866962592607450Mouse
1300618Pgia19_mproteoglycan induced arthritis 19 (mouse)Not determined64531405987426034Mouse
10412157Fl1n_mfatty liver 1 in NSY (mouse)Not determined645314059128835032Mouse
4142259Tabw2_mtally ho associated body weight 2 (mouse)Not determined46935985136423692Mouse
25314319Histh6_mhistamine hypersensitivity 6 (mouse)648720000125360000Mouse
25314320Histh5_mhistamine hypersensitivity 5 (mouse)648720000148450000Mouse
1301962Eila2_methanol induced locomotor activity 2 (mouse)Not determined648726556125356785Mouse
1301254Skts11_mskin tumor susceptibility 11 (mouse)Not determined65117915085179300Mouse
1357683Igf1sl1_mIGF-1 serum levels 1 (mouse)Not determined652161713116155267Mouse
4141028Mclr_mmethylcholanthrene lymphoma resistance (mouse)Not determined5437342788379171Mouse
15039373Adip28_madiposity 28 (mouse)65630821190308211Mouse
15039375Bw41_mbody weight QTL 41 (mouse)65630821190308211Mouse
1558977Skmw10_mskeletal muscle weight 10 (mouse)Not determined65844758392447710Mouse
10043972Obq28_mobesity QTL 28 (mouse)Not determined65854043392540433Mouse
1301740Bwq2_mbody weight QTL 2 (mouse)Not determined66005768094057799Mouse
1301369Im4_mimmunoregulatory 4 (mouse)Not determined66348473897484905Mouse
1300650Bw18_mbody weight QTL 18 (mouse)Not determined666713869100714031Mouse
1301876Bits2_mbitterness sensitivity 2 (mouse)Not determined670425898104426034Mouse
1301813Skl3_mskeletal size (tail length) 3 (mouse)Not determined670425898104426034Mouse
1301034Egrm2_mearly growth rate (mouse)Not determined670425898104426034Mouse
4141990Etax6_methanol induced ataxia 6 (mouse)Not determined7132262186275719Mouse
1302020Bbaa20_mB.burgdorferi-associated arthritis 20 (mouse)Not determined67132262193464093Mouse
1300869Stheal5_msoft tissue heal 5 (mouse)Not determined671575060105575178Mouse
1300954Fcsa1_mfemoral cross-sectional area 1 (mouse)Not determined671981024105981170Mouse
1301521Pas1c_mpulmonary adenoma susceptibility 1c (mouse)Not determined671981024105981170Mouse
13506930Recrq9_mrecombination rate in male meiosis QTL 9 (mouse)673500000134700000Mouse
1301320Ots1_movarian teratoma susceptibility 1 (mouse)Not determined675447583104503555Mouse
1301571Arrd1_mage-related retinal degeneration 1 (mouse)Not determined67554435692607450Mouse
1300674Nidd3n_mnon-insulin-dependent diabetes mellitus 3 in NSY (mouse)Not determined67554435694225955Mouse
10412195Efw_mepididymal fat weight (mouse)Not determined67554435694225955Mouse
10043901Pfat5_mpredicted fat percentage 5 (mouse)Not determined675607306109607450Mouse
10412208Cypr4_mcytokine production 4 (mouse)Not determined675716503109716697Mouse
1357875Pfat2_mpredicted fat percentage 2 (mouse)Not determined676463949110464093Mouse
14697704Stsl4_mSalmonella typhimurium susceptibility locus 4 (mouse)67710000090000000Mouse
13824985Alh1_mamplitude of lateral head displacement 1 (mouse)67800000097000000Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:95
Count of miRNA genes:85
Interacting mature miRNAs:87
Transcripts:ENSMUST00000096904
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000096904   ⟹   ENSMUSP00000094667
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl678,370,861 - 78,373,466 (+)Ensembl
RefSeq Acc Id: ENSMUST00000203266   ⟹   ENSMUSP00000145528
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl678,370,898 - 78,372,908 (+)Ensembl
RefSeq Acc Id: ENSMUST00000204760
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl678,372,531 - 78,373,418 (+)Ensembl
RefSeq Acc Id: ENSMUST00000204873   ⟹   ENSMUSP00000145280
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl678,370,657 - 78,372,898 (+)Ensembl
RefSeq Acc Id: NM_011036   ⟹   NP_035166
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39678,347,868 - 78,350,449 (+)NCBI
GRCm38678,370,885 - 78,373,466 (+)ENTREZGENE
MGSCv37678,320,879 - 78,323,460 (+)RGD
Celera680,394,075 - 80,396,656 (+)RGD
cM Map6 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_035166   ⟸   NM_011036
- Peptide Label: precursor
- UniProtKB: P35230 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000145528   ⟸   ENSMUST00000203266
RefSeq Acc Id: ENSMUSP00000145280   ⟸   ENSMUST00000204873
RefSeq Acc Id: ENSMUSP00000094667   ⟸   ENSMUST00000096904
Protein Domains
C-type lectin

Promoters
RGD ID:6890064
Promoter ID:EPDNEW_M8481
Type:multiple initiation site
Name:Reg3b_1
Description:Mus musculus regenerating islet-derived 3 beta , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38678,370,885 - 78,370,945EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:97478 AgrOrtholog
Ensembl Genes ENSMUSG00000071356 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000094667 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000145280 UniProtKB/TrEMBL
  ENSMUSP00000145528 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000096904 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000203266 UniProtKB/TrEMBL
  ENSMUST00000204873 UniProtKB/TrEMBL
Gene3D-CATH 3.10.100.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro C-type_lectin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C-type_lectin-like/link_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C-type_lectin_CS UniProtKB/Swiss-Prot
  CTDL_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:18489 UniProtKB/Swiss-Prot
MGD MGI:97478 ENTREZGENE
NCBI Gene 18489 ENTREZGENE
Pfam Lectin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Reg3b PhenoGen
PROSITE C_TYPE_LECTIN_1 UniProtKB/Swiss-Prot
  C_TYPE_LECTIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART CLECT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56436 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0N4SVX1_MOUSE UniProtKB/TrEMBL
  A0A0N4SWI2_MOUSE UniProtKB/TrEMBL
  P35230 ENTREZGENE, UniProtKB/Swiss-Prot