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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:chromenone
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Accession:CHEBI:38445 term browser browse the term
Synonyms:related_synonym: chromenones

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3,4-dihydrocoumarin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ddit3 DNA-damage inducible transcript 3 affects expression ISO 3,4-dihydrocoumarin affects the expression of DDIT3 mRNA CTD PMID:22016648 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084 		JBrowse link
G Dnaja2 DnaJ heat shock protein family (Hsp40) member A2 decreases expression ISO 3,4-dihydrocoumarin results in decreased expression of DNAJA2 mRNA CTD PMID:22016648 NCBI chr19:22,569,999...22,588,143
Ensembl chr19:22,569,999...22,588,137 		JBrowse link
G Egf epidermal growth factor increases expression ISO 3,4-dihydrocoumarin results in increased expression of EGF mRNA CTD PMID:22016648 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Ephx1 epoxide hydrolase 1 decreases expression ISO 3,4-dihydrocoumarin results in decreased expression of EPHX1 mRNA CTD PMID:22016648 NCBI chr13:99,271,390...99,300,580
Ensembl chr13:99,271,366...99,300,579 		JBrowse link
G Hsd17b4 hydroxysteroid (17-beta) dehydrogenase 4 increases expression ISO 3,4-dihydrocoumarin results in increased expression of HSD17B4 mRNA CTD PMID:22016648 NCBI chr18:44,810,462...44,897,677
Ensembl chr18:44,810,388...44,897,640 		JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 decreases expression ISO 3,4-dihydrocoumarin results in decreased expression of HSP90AB1 mRNA CTD PMID:22016648 NCBI chr 9:17,817,791...17,823,163
Ensembl chr 9:17,817,721...17,823,243 		JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A increases expression ISO 3,4-dihydrocoumarin results in increased expression of HSPA1A mRNA CTD PMID:22016648 NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779 		JBrowse link
G Oat ornithine aminotransferase decreases expression ISO 3,4-dihydrocoumarin results in decreased expression of OAT mRNA CTD PMID:22016648 NCBI chr 1:204,562,289...204,582,070
Ensembl chr 1:204,562,289...204,582,070 		JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 decreases expression ISO 3,4-dihydrocoumarin results in decreased expression of PCK1 mRNA CTD PMID:22016648 NCBI chr 3:171,213,936...171,219,885
Ensembl chr 3:171,213,936...171,219,871 		JBrowse link
G Pon1 paraoxonase 1 affects metabolic processing ISO PON1 SNP affects the metabolism of 3,4-dihydrocoumarin CTD PMID:25027835 NCBI chr 4:30,249,749...30,276,297
Ensembl chr 4:30,249,742...30,276,372 		JBrowse link
G Prdx1 peroxiredoxin 1 increases expression ISO 3,4-dihydrocoumarin results in increased expression of PRDX1 mRNA CTD PMID:22016648 NCBI chr 5:135,536,413...135,551,986
Ensembl chr 5:135,536,413...135,551,990 		JBrowse link
G Prdx3 peroxiredoxin 3 decreases expression ISO 3,4-dihydrocoumarin results in decreased expression of PRDX3 mRNA CTD PMID:22016648 NCBI chr 1:282,238,774...282,251,193
Ensembl chr 1:282,238,773...282,251,257 		JBrowse link
G Psmb8 proteasome 20S subunit beta 8 decreases expression ISO 3,4-dihydrocoumarin results in decreased expression of PSMB8 mRNA CTD PMID:22016648 NCBI chr20:3,990,809...3,993,772
Ensembl chr20:3,990,613...3,993,769 		JBrowse link
G Ptpmt1 protein tyrosine phosphatase, mitochondrial 1 decreases expression ISO 3,4-dihydrocoumarin results in decreased expression of PTPMT1 mRNA CTD PMID:22016648 NCBI chr 3:79,734,961...79,743,737
Ensembl chr 3:79,734,961...79,743,737 		JBrowse link
G Rbp4 retinol binding protein 4 decreases expression ISO 3,4-dihydrocoumarin results in decreased expression of RBP4 mRNA CTD PMID:22016648 NCBI chr 1:256,806,476...256,813,678
Ensembl chr 1:256,806,472...256,813,711 		JBrowse link
G Sod1 superoxide dismutase 1 decreases expression ISO 3,4-dihydrocoumarin results in decreased expression of SOD1 mRNA CTD PMID:22016648 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862 		JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 decreases expression ISO 3,4-dihydrocoumarin results in decreased expression of TIMP2 mRNA CTD PMID:22016648 NCBI chr10:107,338,465...107,386,072
Ensembl chr10:107,338,465...107,386,072 		JBrowse link
G Tubb5 tubulin, beta 5 class I decreases expression ISO 3,4-dihydrocoumarin results in decreased expression of TUBB5 mRNA CTD PMID:22016648 NCBI chr20:3,422,448...3,426,420
Ensembl chr20:3,422,461...3,426,371 		JBrowse link
4-hydroxycoumarin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrm1 adhesion regulating molecule 1 decreases expression ISO 4-hydroxycoumarin results in decreased expression of ADRM1 mRNA CTD PMID:18492274 NCBI chr 3:175,548,181...175,552,943
Ensembl chr 3:175,548,174...175,552,947 		JBrowse link
G Ptk2 protein tyrosine kinase 2 decreases phosphorylation ISO 4-hydroxycoumarin results in decreased phosphorylation of PTK2 protein CTD PMID:18492274 NCBI chr 7:114,436,419...114,611,317
Ensembl chr 7:114,437,361...114,590,119 		JBrowse link
G Pxn paxillin decreases expression
decreases phosphorylation
affects localization		 ISO 4-hydroxycoumarin results in decreased expression of PXN mRNA alternative form; 4-hydroxycoumarin results in decreased expression of PXN protein alternative form
4-hydroxycoumarin results in decreased phosphorylation of PXN protein
4-hydroxycoumarin affects the localization of PXN protein		 CTD PMID:18492274 NCBI chr12:46,797,953...46,845,107
Ensembl chr12:46,797,954...46,845,080 		JBrowse link
G Rac1 Rac family small GTPase 1 decreases expression ISO 4-hydroxycoumarin results in decreased expression of RAC1 protein CTD PMID:18492274 NCBI chr12:13,090,316...13,111,841
Ensembl chr12:13,090,172...13,111,873 		JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 increases metabolic processing
affects metabolic processing		 EXP UGT1A6 protein results in increased metabolism of 4-hydroxycoumarin
UGT1A6 gene polymorphism affects the metabolism of 4-hydroxycoumarin		 CTD PMID:9429234 NCBI chr 9:95,241,609...95,302,822
Ensembl chr 9:95,161,157...95,302,822 		JBrowse link
G Vkorc1 vitamin K epoxide reductase complex, subunit 1 decreases activity
multiple interactions		 ISO 4-hydroxycoumarin results in decreased activity of VKORC1 protein
4-hydroxycoumarin inhibits the reaction [VKORC1 protein results in increased reduction of Vitamin K 1]		 CTD PMID:29581108 NCBI chr 1:199,338,785...199,341,306
Ensembl chr 1:199,337,138...199,341,302 		JBrowse link
G Vkorc1l1 vitamin K epoxide reductase complex, subunit 1-like 1 multiple interactions
decreases activity		 ISO 4-hydroxycoumarin inhibits the reaction [VKORC1L1 protein results in increased reduction of Vitamin K 1]
4-hydroxycoumarin results in decreased activity of VKORC1L1 protein		 CTD PMID:29581108 NCBI chr12:30,218,825...30,268,990
Ensembl chr12:30,222,701...30,268,990 		JBrowse link
4-methylumbelliferone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg2 ATP binding cassette subfamily G member 2 affects export ISO ABCG2 protein affects the export of Hymecromone analog CTD PMID:15598971 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions ISO Hymecromone inhibits the reaction [Dietary Fats results in decreased expression of ADIPOQ protein] CTD PMID:24661945 NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488 		JBrowse link
G Cat catalase multiple interactions ISO Hymecromone inhibits the reaction [Dietary Fats results in decreased activity of CAT protein] CTD PMID:24661945 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO Hymecromone inhibits the reaction [Dietary Fats results in increased activity of CYP2E1 protein] CTD PMID:24661945 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542 		JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 increases sulfation ISO
EXP		 SULT1A1 protein results in increased sulfation of Hymecromone CTD PMID:11181495 NCBI chr 1:198,100,586...198,104,106
Ensembl chr 1:198,100,586...198,104,109 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 multiple interactions
increases metabolic processing
increases activity
increases glucuronidation		 ISO [UGT1A1 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; Estradiol promotes the reaction [UGT1A1 protein results in increased glucuronidation of Hymecromone]; licochalcone A inhibits the reaction [Hymecromone results in increased activity of UGT1A1 protein]; pterostilbene inhibits the reaction [[UGT1A1 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide] CTD PMID:15378558, PMID:15593333, PMID:15802387, PMID:26875642, PMID:31812603 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822 		JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases activity
increases metabolic processing
multiple interactions
increases glucuronidation		 ISO Hymecromone results in increased activity of UGT1A3 protein
UGT1A3 protein results in increased metabolism of Hymecromone
[UGT1A3 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; licochalcone A inhibits the reaction [Hymecromone results in increased activity of UGT1A3 protein]; pterostilbene inhibits the reaction [[UGT1A3 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]
UGT1A3 protein results in increased glucuronidation of Hymecromone		 CTD PMID:15802387, PMID:26875642, PMID:31812603 NCBI chr 9:95,285,592...95,302,822
Ensembl chr 9:95,161,157...95,302,822 		JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 affects metabolic processing
increases metabolic processing
increases activity
multiple interactions
increases glucuronidation		 EXP
ISO		 UGT1A6 gene polymorphism affects the metabolism of Hymecromone
UGT1A6 protein results in increased metabolism of Hymecromone
Hymecromone results in increased activity of UGT1A6 protein
[UGT1A6 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; bisphenol A inhibits the reaction [UGT1A6 protein results in increased glucuronidation of Hymecromone]; licochalcone A inhibits the reaction [Hymecromone results in increased activity of UGT1A6 protein]; pterostilbene inhibits the reaction [[UGT1A6 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]		 CTD PMID:9429234, PMID:15802387, PMID:18214896, PMID:25393417, PMID:26875642, PMID:31812603 NCBI chr 9:95,241,609...95,302,822
Ensembl chr 9:95,161,157...95,302,822 		JBrowse link
G Ugt1a7c UDP glucuronosyltransferase 1 family, polypeptide A7C increases glucuronidation EXP UGT1A7 protein results in increased glucuronidation of Hymecromone CTD PMID:15502008 NCBI chr 9:95,233,957...95,302,822
Ensembl chr 9:95,161,157...95,302,822 		JBrowse link
G Ugt1a8 UDP glucuronosyltransferase family 1 member A8 increases glucuronidation
increases metabolic processing
multiple interactions
increases activity		 EXP
ISO		 UGT1A8 protein results in increased glucuronidation of Hymecromone
UGT1A8 protein results in increased metabolism of Hymecromone
[UGT1A8 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; licochalcone A inhibits the reaction [Hymecromone results in increased activity of UGT1A8 protein]; Propofol promotes the reaction [UGT1A8 protein results in increased glucuronidation of Hymecromone]; pterostilbene inhibits the reaction [[UGT1A8 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]		 CTD PMID:15378558, PMID:15502008, PMID:15802387, PMID:26875642, PMID:31812603 NCBI chr 9:95,221,474...95,302,822
Ensembl chr 9:95,161,157...95,302,822 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation
increases metabolic processing
increases activity
multiple interactions		 ISO UGT1A9 protein results in increased glucuronidation of Hymecromone
UGT1A9 protein results in increased metabolism of Hymecromone
Hymecromone results in increased activity of UGT1A9 protein
[UGT1A9 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; licochalcone A inhibits the reaction [Hymecromone results in increased activity of UGT1A9 protein]; pterostilbene inhibits the reaction [[UGT1A9 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]		 CTD PMID:15378558, PMID:15802387, PMID:26875642, PMID:31812603 NCBI chr 9:95,161,157...95,302,822
Ensembl chr 9:95,161,157...95,302,822 		JBrowse link
G Ugt2a1 UDP glucuronosyltransferase family 2 member A1 increases glucuronidation ISO UGT2A1 protein results in increased glucuronidation of Hymecromone CTD PMID:21164388 NCBI chr14:22,192,970...22,217,094 JBrowse link
G Ugt2b17 UDP glucuronosyltransferase family 2 member B17 increases glucuronidation
increases activity
increases metabolic processing
multiple interactions		 EXP
ISO		 UGT2B1 protein results in increased glucuronidation of Hymecromone
Hymecromone results in increased activity of UGT2B17 protein
UGT2B17 protein results in increased metabolism of Hymecromone
licochalcone A inhibits the reaction [Hymecromone results in increased activity of UGT2B17 protein]		 CTD PMID:8302279, PMID:8798464, PMID:26875642 NCBI chr14:22,724,399...22,736,148
Ensembl chr14:22,724,070...22,825,444 		JBrowse link
G Ugt2b35 UDP glucuronosyltransferase 2 family, polypeptide B35 increases metabolic processing EXP UGT2B15 protein results in increased metabolism of Hymecromone CTD PMID:7574722 NCBI chr14:22,553,633...22,591,461
Ensembl chr14:22,553,650...22,591,461 		JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 increases activity
increases metabolic processing
multiple interactions		 ISO Hymecromone results in increased activity of UGT2B7 protein
UGT2B7 protein results in increased metabolism of Hymecromone
[UGT2B7 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; licochalcone A inhibits the reaction [Hymecromone results in increased activity of UGT2B7 protein]; pterostilbene inhibits the reaction [[UGT2B7 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]		 CTD PMID:26875642, PMID:31812603 NCBI chr14:22,597,103...22,619,968 JBrowse link
4-methylumbelliferone beta-D-glucuronide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 multiple interactions ISO [UGT1A1 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; pterostilbene inhibits the reaction [[UGT1A1 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide] CTD PMID:31812603 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822 		JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 multiple interactions ISO [UGT1A3 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; pterostilbene inhibits the reaction [[UGT1A3 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide] CTD PMID:31812603 NCBI chr 9:95,285,592...95,302,822
Ensembl chr 9:95,161,157...95,302,822 		JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 multiple interactions ISO [UGT1A6 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; pterostilbene inhibits the reaction [[UGT1A6 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide] CTD PMID:31812603 NCBI chr 9:95,241,609...95,302,822
Ensembl chr 9:95,161,157...95,302,822 		JBrowse link
G Ugt1a8 UDP glucuronosyltransferase family 1 member A8 multiple interactions ISO [UGT1A8 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; pterostilbene inhibits the reaction [[UGT1A8 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide] CTD PMID:31812603 NCBI chr 9:95,221,474...95,302,822
Ensembl chr 9:95,161,157...95,302,822 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 multiple interactions ISO [UGT1A9 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; pterostilbene inhibits the reaction [[UGT1A9 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide] CTD PMID:31812603 NCBI chr 9:95,161,157...95,302,822
Ensembl chr 9:95,161,157...95,302,822 		JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 multiple interactions ISO [UGT2B7 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; pterostilbene inhibits the reaction [[UGT2B7 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide] CTD PMID:31812603 NCBI chr14:22,597,103...22,619,968 JBrowse link
4-methylumbelliferone sulfate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc22a25 solute carrier family 22, member 25 multiple interactions EXP 4-methylumbelliferyl sulfate inhibits the reaction [SLC22A9 protein affects the transport of estrone sulfate] CTD PMID:18441515 NCBI chr 1:224,596,886...224,698,512
Ensembl chr 1:224,596,887...224,698,514 		JBrowse link
4-methylumbelliferyl acetate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Calr calreticulin increases activity ISO 4-methylumbelliferyl acetate results in increased activity of CALR protein CTD PMID:20188080 NCBI chr19:25,956,771...25,961,666
Ensembl chr19:25,956,771...25,961,666 		JBrowse link
G Ces1d carboxylesterase 1D multiple interactions
increases hydrolysis		 ISO Atropine inhibits the reaction [CES1 protein results in increased hydrolysis of 4-methylumbelliferyl acetate]; Cocaine inhibits the reaction [CES1 protein results in increased hydrolysis of 4-methylumbelliferyl acetate]; tropacocaine inhibits the reaction [CES1 protein results in increased hydrolysis of 4-methylumbelliferyl acetate] CTD PMID:9311626 NCBI chr19:15,195,514...15,239,827
Ensembl chr19:15,033,108...15,239,821 		JBrowse link
G Ces2h carboxylesterase 2H increases hydrolysis ISO CES2 protein results in increased hydrolysis of 4-methylumbelliferyl acetate CTD PMID:9169443 NCBI chr19:37,052,555...37,067,176
Ensembl chr19:37,052,556...37,067,156 		JBrowse link
G Txn1 thioredoxin 1 increases activity ISO 4-methylumbelliferyl acetate results in increased activity of TXN protein CTD PMID:24103856 NCBI chr 5:75,049,735...75,057,731
Ensembl chr 5:75,049,747...75,057,752 		JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO 4-methylumbelliferyl acetate results in increased expression of VEGFA protein CTD PMID:24103856 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681 		JBrowse link
4-methylumbelliferyl beta-D-galactoside term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ca12 carbonic anhydrase 12 decreases activity ISO 4-methylumbelliferyl-galactopyranoside analog results in decreased activity of CA12 protein CTD PMID:22077347 NCBI chr 8:72,405,770...72,461,425
Ensembl chr 8:72,405,748...72,460,240 		JBrowse link
G Ca9 carbonic anhydrase 9 decreases activity ISO 4-methylumbelliferyl-galactopyranoside analog results in decreased activity of CA9 protein CTD PMID:22077347 NCBI chr 5:59,008,277...59,015,535
Ensembl chr 5:59,008,933...59,015,528 		JBrowse link
4-methylumbelliferyl beta-D-glucoside term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gaa glucosidase, alpha, acid multiple interactions
increases metabolic processing		 ISO GAA gene SNP inhibits the reaction [GAA protein results in increased metabolism of 4-methylumbelliferyl glucoside] CTD PMID:21963784 NCBI chr10:108,395,873...108,412,999
Ensembl chr10:108,395,860...108,413,059 		JBrowse link
4-phenylcoumarin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase increases expression ISO 4-phenylcoumarin analog results in increased expression of ABL1 mRNA CTD PMID:27773722 NCBI chr 3:10,041,820...10,145,076
Ensembl chr 3:10,041,826...10,144,388 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO 4-phenylcoumarin analog results in increased expression of DDIT3 mRNA CTD PMID:27773722 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression ISO 4-phenylcoumarin analog results in increased expression of GADD45A mRNA CTD PMID:27773722 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842 		JBrowse link
G Gadd45g growth arrest and DNA-damage-inducible, gamma increases expression ISO 4-phenylcoumarin analog results in increased expression of GADD45G mRNA CTD PMID:27773722 NCBI chr17:13,391,474...13,393,219
Ensembl chr17:13,391,467...13,393,243 		JBrowse link
G Mlh3 mutL homolog 3 increases expression ISO 4-phenylcoumarin analog results in increased expression of MLH3 mRNA CTD PMID:27773722 NCBI chr 6:109,059,386...109,095,876
Ensembl chr 6:109,059,341...109,095,557 		JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A increases expression ISO 4-phenylcoumarin analog results in increased expression of PPP1R15A mRNA CTD PMID:27773722 NCBI chr 1:101,511,899...101,515,043
Ensembl chr 1:101,511,901...101,514,974 		JBrowse link
7,8-dihydroxycoumarin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO daphnetin inhibits the reaction [sodium arsenite results in increased expression of BAX protein] CTD PMID:30738023 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO daphnetin inhibits the reaction [sodium arsenite results in decreased expression of BCL2 protein] CTD PMID:30738023 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO daphnetin results in increased expression of GCLC protein CTD PMID:30738023 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO daphnetin results in increased expression of GCLM protein CTD PMID:30738023 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions		 ISO daphnetin results in increased expression of HMOX1 protein
[sodium arsenite co-treated with daphnetin] results in increased expression of HMOX1 protein; NFE2L2 protein affects the reaction [daphnetin results in increased expression of HMOX1 protein]		 CTD PMID:30738023 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456 		JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 decreases expression ISO daphnetin results in decreased expression of KEAP1 protein CTD PMID:30738023 NCBI chr 8:22,250,518...22,259,868
Ensembl chr 8:22,250,518...22,259,779 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO daphnetin results in increased phosphorylation of MAPK1 protein CTD PMID:30738023 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO daphnetin results in increased phosphorylation of MAPK3 protein CTD PMID:30738023 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO [sodium arsenite co-treated with daphnetin] results in increased expression of NFE2L2 protein; daphnetin results in increased expression of and affects the localization of NFE2L2 protein; NFE2L2 protein affects the reaction [daphnetin results in increased expression of HMOX1 protein] CTD PMID:30738023 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO daphnetin results in increased expression of NQO1 protein CTD PMID:30738023 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180 		JBrowse link
7-ethoxycoumarin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases metabolic processing ISO CYP2E1 protein results in increased metabolism of 7-ethoxycoumarin CTD PMID:18385292 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542 		JBrowse link
7-hydroxycoumarin O(7)-glucosiduronic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ugt2b35 UDP glucuronosyltransferase 2 family, polypeptide B35 increases abundance EXP UGT2B15 protein results in increased abundance of 7-hydroxycoumarin glucuronide CTD PMID:7574722 NCBI chr14:22,553,633...22,591,461
Ensembl chr14:22,553,650...22,591,461 		JBrowse link
acenocoumarol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A affects response to substance ISO ABCB1 gene polymorphism affects the susceptibility to Acenocoumarol CTD PMID:18021343 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515 		JBrowse link
G Apoe apolipoprotein E affects response to substance ISO APOE gene polymorphism affects the susceptibility to Acenocoumarol CTD PMID:15861030 NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 affects metabolic processing ISO CYP1A1 protein affects the metabolism of Acenocoumarol CTD PMID:11918509 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 affects metabolic processing ISO CYP1A2 protein affects the metabolism of Acenocoumarol CTD PMID:11918509 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301 		JBrowse link
G Cyp2c24 cytochrome P450, family 2, subfamily c, polypeptide 24 affects response to substance ISO CYP2C18 gene polymorphism affects the susceptibility to Acenocoumarol CTD PMID:19578179 NCBI chr 1:258,074,797...258,139,176
Ensembl chr 1:258,074,860...258,139,176 		JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 affects metabolic processing ISO CYP2C19 protein affects the metabolism of Acenocoumarol CTD PMID:11918509 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007 		JBrowse link
G F10 coagulation factor X decreases activity EXP Acenocoumarol results in decreased activity of F10 protein CTD PMID:3490277 NCBI chr16:81,803,169...81,822,476
Ensembl chr16:81,803,110...81,822,716 		JBrowse link
G F2 coagulation factor II decreases activity EXP Acenocoumarol results in decreased activity of F2 protein CTD PMID:3490277 NCBI chr 3:80,529,468...80,542,993
Ensembl chr 3:80,529,428...80,543,031 		JBrowse link
G F5 coagulation factor V decreases activity EXP Acenocoumarol results in decreased activity of F5 protein CTD PMID:3490277 NCBI chr13:82,479,997...82,535,540
Ensembl chr13:82,479,998...82,535,534 		JBrowse link
G F7 coagulation factor VII decreases activity EXP Acenocoumarol results in decreased activity of F7 protein CTD PMID:3490277 NCBI chr16:81,824,610...81,834,923
Ensembl chr16:81,824,111...81,834,945 		JBrowse link
G F9 coagulation factor IX decreases activity EXP Acenocoumarol results in decreased activity of F9 protein CTD PMID:3490277 NCBI chr  X:143,097,507...143,141,791
Ensembl chr  X:143,097,525...143,141,794 		JBrowse link
G Ggcx gamma-glutamyl carboxylase increases activity EXP Acenocoumarol results in increased activity of GGCX protein CTD PMID:3490277 NCBI chr 4:100,277,345...100,293,097
Ensembl chr 4:100,277,391...100,293,250 		JBrowse link
G Vkorc1 vitamin K epoxide reductase complex, subunit 1 decreases response to substance
decreases activity
multiple interactions
affects response to substance
increases response to substance		 ISO VKORC1 promoter polymorphism results in decreased susceptibility to Acenocoumarol; VKORC1 protein polymorphism results in decreased susceptibility to Acenocoumarol
Acenocoumarol results in decreased activity of VKORC1 protein
Acenocoumarol inhibits the reaction [VKORC1 protein results in increased reduction of Vitamin K 1]
VKORC1 gene polymorphism affects the susceptibility to Acenocoumarol; VKORC1 gene SNP affects the susceptibility to Acenocoumarol; VKORC1 intron SNP affects the susceptibility to Acenocoumarol; VKORC1 polymorphism affects the susceptibility to Acenocoumarol; VKORC1 protein polymorphism affects the susceptibility to Acenocoumarol
VKORC1 protein results in increased susceptibility to Acenocoumarol		 CTD PMID:16201835, PMID:16611310, PMID:16869821, PMID:17036862, PMID:18698879, PMID:19578179, PMID:19875892, PMID:25042728, PMID:25866574, PMID:26757860, PMID:28867752, PMID:29581108 NCBI chr 1:199,338,785...199,341,306
Ensembl chr 1:199,337,138...199,341,302 		JBrowse link
G Vkorc1l1 vitamin K epoxide reductase complex, subunit 1-like 1 multiple interactions
decreases activity		 ISO Acenocoumarol inhibits the reaction [VKORC1L1 protein results in increased reduction of Vitamin K 1]
Acenocoumarol results in decreased activity of VKORC1L1 protein		 CTD PMID:29581108 NCBI chr12:30,218,825...30,268,990
Ensembl chr12:30,222,701...30,268,990 		JBrowse link
Aflatoxin G1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atm ATM serine/threonine kinase increases expression
multiple interactions
increases activity		 ISO aflatoxin G1 results in increased expression of ATM protein modified form
Methoxsalen inhibits the reaction [aflatoxin G1 results in increased expression of ATM protein modified form]; Nicotine inhibits the reaction [aflatoxin G1 results in increased expression of ATM protein modified form]
aflatoxin G1 results in increased activity of ATM protein		 CTD PMID:23907605 NCBI chr 8:58,015,938...58,119,973
Ensembl chr 8:58,015,940...58,120,045 		JBrowse link
G Atr ATR serine/threonine kinase increases expression
multiple interactions
increases activity		 ISO aflatoxin G1 results in increased expression of ATR protein modified form
Methoxsalen inhibits the reaction [aflatoxin G1 results in increased expression of ATR protein modified form]; Nicotine inhibits the reaction [aflatoxin G1 results in increased expression of ATR protein modified form]
aflatoxin G1 results in increased activity of ATR protein		 CTD PMID:23907605 NCBI chr 8:103,673,578...103,770,886
Ensembl chr 8:103,673,411...103,770,947 		JBrowse link
G Brca1 BRCA1, DNA repair associated increases activity
multiple interactions
increases expression		 ISO aflatoxin G1 results in increased activity of BRCA1 protein
Methoxsalen inhibits the reaction [aflatoxin G1 results in increased expression of BRCA1 protein modified form]; Nicotine inhibits the reaction [aflatoxin G1 results in increased expression of BRCA1 protein modified form]		 CTD PMID:23907605 NCBI chr10:89,394,821...89,455,093
Ensembl chr10:89,394,803...89,454,681 		JBrowse link
G Casp3 caspase 3 increases expression
multiple interactions		 ISO aflatoxin G1 results in increased expression of CASP3 protein modified form
Methoxsalen inhibits the reaction [aflatoxin G1 results in increased expression of CASP3 protein modified form]; Nicotine inhibits the reaction [aflatoxin G1 results in increased expression of CASP3 protein modified form]		 CTD PMID:23907605 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression ISO aflatoxin G1 results in increased expression of CCL2 mRNA CTD PMID:25445582 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870 		JBrowse link
G Chek2 checkpoint kinase 2 multiple interactions
increases expression
increases activity		 ISO Methoxsalen inhibits the reaction [aflatoxin G1 results in increased expression of CHEK2 protein modified form]; Nicotine inhibits the reaction [aflatoxin G1 results in increased expression of CHEK2 protein modified form]
aflatoxin G1 results in increased activity of CHEK2 protein		 CTD PMID:23907605 NCBI chr12:51,845,574...51,878,098
Ensembl chr12:51,845,796...51,877,624 		JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 increases expression ISO aflatoxin G1 results in increased expression of CXCL2 mRNA CTD PMID:25445582 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391 		JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 increases expression ISO aflatoxin G1 results in increased expression of CXCL1 mRNA CTD PMID:25445582 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases response to substance ISO CYP1A2 protein results in increased susceptibility to aflatoxin G1 CTD PMID:11189750 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301 		JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases response to substance ISO CYP3A5 protein results in increased susceptibility to aflatoxin G1 CTD PMID:11189750 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399 		JBrowse link
G H2ax H2A.X variant histone increases expression
multiple interactions		 ISO aflatoxin G1 results in increased expression of H2AX protein modified form
Methoxsalen inhibits the reaction [aflatoxin G1 results in increased expression of H2AX protein modified form]; Nicotine inhibits the reaction [aflatoxin G1 results in increased expression of H2AX protein modified form]		 CTD PMID:23907605 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO aflatoxin G1 results in increased expression of HMOX1 protein CTD PMID:25445582 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456 		JBrowse link
G Il10 interleukin 10 multiple interactions ISO aflatoxin G1 inhibits the reaction [Lipopolysaccharides results in increased secretion of IL10 protein] CTD PMID:22445859 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392 		JBrowse link
G Il12b interleukin 12B multiple interactions ISO [aflatoxin G1 co-treated with Aflatoxin B1] inhibits the reaction [Lipopolysaccharides results in increased secretion of IL12B protein]; [aflatoxin G1 co-treated with aflatoxin B2] inhibits the reaction [Lipopolysaccharides results in increased secretion of IL12B protein] CTD PMID:22445859 NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085 		JBrowse link
G Il1b interleukin 1 beta increases expression ISO aflatoxin G1 results in increased expression of IL1B mRNA CTD PMID:25445582 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Il6 interleukin 6 increases expression ISO aflatoxin G1 results in increased expression of IL6 mRNA CTD PMID:25445582 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G LOC100364500 RT1 class I, locus CE11-like decreases expression ISO aflatoxin G1 results in decreased expression of HLA-A mRNA CTD PMID:20381597 NCBI chr20:2,704,153...2,707,111
Ensembl chr20:2,704,148...2,707,120 		JBrowse link
G Mrpl12 mitochondrial ribosomal protein L12 multiple interactions ISO [Aflatoxin B1 co-treated with aflatoxin B2 co-treated with aflatoxin G1 co-treated with aflatoxin G2] results in decreased expression of MRPL12 mRNA; [Plant Extracts co-treated with Aflatoxin B1 co-treated with aflatoxin B2 co-treated with aflatoxin G1 co-treated with aflatoxin G2] results in decreased expression of MRPL12 mRNA CTD PMID:31904472 NCBI chr10:109,658,032...109,662,535
Ensembl chr10:109,658,032...109,662,535 		JBrowse link
G Mt-atp8 mitochondrially encoded ATP synthase membrane subunit 8 multiple interactions ISO [Aflatoxin B1 co-treated with aflatoxin B2 co-treated with aflatoxin G1 co-treated with aflatoxin G2] results in decreased expression of ATP8 mRNA; [Plant Extracts co-treated with Aflatoxin B1 co-treated with aflatoxin B2 co-treated with aflatoxin G1 co-treated with aflatoxin G2] results in increased expression of ATP8 mRNA CTD PMID:31904472 NCBI chr MT:7,758...7,961
Ensembl chr MT:7,758...7,961 		JBrowse link
G Mt-co1 mitochondrially encoded cytochrome c oxidase I multiple interactions ISO [Aflatoxin B1 co-treated with aflatoxin B2 co-treated with aflatoxin G1 co-treated with aflatoxin G2] results in decreased expression of COX1 mRNA; [Plant Extracts co-treated with Aflatoxin B1 co-treated with aflatoxin B2 co-treated with aflatoxin G1 co-treated with aflatoxin G2] results in decreased expression of COX1 mRNA CTD PMID:31904472 NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867 		JBrowse link
G Mt-co3 mitochondrially encoded cytochrome c oxidase III multiple interactions ISO [Plant Extracts co-treated with Aflatoxin B1 co-treated with aflatoxin B2 co-treated with aflatoxin G1 co-treated with aflatoxin G2] results in increased expression of COX3 mRNA CTD PMID:31904472 NCBI chr MT:8,599...9,382
Ensembl chr MT:8,599...9,382 		JBrowse link
G Mt-nd3 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 3 multiple interactions ISO [Aflatoxin B1 co-treated with aflatoxin B2 co-treated with aflatoxin G1 co-treated with aflatoxin G2] results in increased expression of ND3 mRNA; [Plant Extracts co-treated with Aflatoxin B1 co-treated with aflatoxin B2 co-treated with aflatoxin G1 co-treated with aflatoxin G2] results in increased expression of ND3 mRNA CTD PMID:31904472 NCBI chr MT:9,451...9,798
Ensembl chr MT:9,451...9,798 		JBrowse link
G Mt-nd4 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4 multiple interactions ISO [Aflatoxin B1 co-treated with aflatoxin B2 co-treated with aflatoxin G1 co-treated with aflatoxin G2] results in increased expression of ND4 mRNA; [Plant Extracts co-treated with Aflatoxin B1 co-treated with aflatoxin B2 co-treated with aflatoxin G1 co-treated with aflatoxin G2] results in increased expression of ND4 mRNA CTD PMID:31904472 NCBI chr MT:10,160...11,537
Ensembl chr MT:10,160...11,537 		JBrowse link
G Mt-nd4l mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4L multiple interactions ISO [Aflatoxin B1 co-treated with aflatoxin B2 co-treated with aflatoxin G1 co-treated with aflatoxin G2] results in increased expression of ND4L mRNA; [Plant Extracts co-treated with Aflatoxin B1 co-treated with aflatoxin B2 co-treated with aflatoxin G1 co-treated with aflatoxin G2] results in increased expression of ND4L mRNA CTD PMID:31904472 NCBI chr MT:9,870...10,166
Ensembl chr MT:9,870...10,166 		JBrowse link
G Mt-nd5 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 5 multiple interactions ISO [Aflatoxin B1 co-treated with aflatoxin B2 co-treated with aflatoxin G1 co-treated with aflatoxin G2] results in decreased expression of ND5 mRNA CTD PMID:31904472 NCBI chr MT:11,736...13,565
Ensembl chr MT:11,736...13,565 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
increases activity		 ISO aflatoxin G1 promotes the reaction [NR1I2 protein binds to CYP3A4 promoter]
aflatoxin G1 results in increased activity of NR1I2 protein		 CTD PMID:21641981 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545 		JBrowse link
G Osgin1 oxidative stress induced growth inhibitor 1 multiple interactions ISO [Plant Extracts co-treated with Aflatoxin B1 co-treated with aflatoxin B2 co-treated with aflatoxin G1 co-treated with aflatoxin G2] results in decreased expression of OSGIN1 mRNA CTD PMID:31904472 NCBI chr19:52,056,808...52,085,491
Ensembl chr19:52,077,109...52,085,496 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases expression ISO aflatoxin G1 results in increased expression of PARP1 protein modified form CTD PMID:23907605 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716 		JBrowse link
G Psmb9 proteasome 20S subunit beta 9 decreases expression ISO aflatoxin G1 results in decreased expression of PSMB9 protein CTD PMID:20381597 NCBI chr20:3,973,424...3,978,845
Ensembl chr20:3,973,420...3,978,845 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO aflatoxin G1 results in increased expression of PTGS2 protein CTD PMID:25445582 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO aflatoxin G1 results in increased expression of and affects the localization of RELA protein CTD PMID:25445582 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G Sod2 superoxide dismutase 2 increases expression ISO aflatoxin G1 results in increased expression of SOD2 protein CTD PMID:25445582 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587 		JBrowse link
G Srxn1 sulfiredoxin 1 multiple interactions ISO [Plant Extracts co-treated with Aflatoxin B1 co-treated with aflatoxin B2 co-treated with aflatoxin G1 co-treated with aflatoxin G2] results in decreased expression of SRXN1 mRNA CTD PMID:31904472 NCBI chr 3:147,608,850...147,614,410
Ensembl chr 3:147,609,095...147,632,801 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases phosphorylation ISO aflatoxin G1 results in increased phosphorylation of STAT3 protein CTD PMID:25445582 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233 		JBrowse link
G Tap1 transporter 1, ATP binding cassette subfamily B member decreases expression ISO aflatoxin G1 results in decreased expression of TAP1 mRNA; aflatoxin G1 results in decreased expression of TAP1 protein CTD PMID:20381597 NCBI chr20:3,979,302...3,989,669
Ensembl chr20:3,979,035...3,989,669 		JBrowse link
G Tlr2 toll-like receptor 2 multiple interactions ISO aflatoxin G1 inhibits the reaction [Lipopolysaccharides results in increased expression of TLR2 protein] CTD PMID:22445859 NCBI chr 2:182,840,171...182,846,061
Ensembl chr 2:182,840,727...182,846,061 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression		 ISO [aflatoxin G1 co-treated with Aflatoxin B1] inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; aflatoxin G1 inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
aflatoxin G1 results in increased expression of TNF mRNA; aflatoxin G1 results in increased expression of TNF protein		 CTD PMID:22445859, PMID:25445582 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Tp53 tumor protein p53 increases expression
increases activity
multiple interactions		 ISO aflatoxin G1 results in increased expression of TP53 protein modified form
aflatoxin G1 results in increased activity of TP53 protein
Methoxsalen inhibits the reaction [aflatoxin G1 results in increased expression of TP53 protein modified form]; Nicotine inhibits the reaction [aflatoxin G1 results in increased expression of TP53 protein modified form]		 CTD PMID:23907605 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449 		JBrowse link
G Txnip thioredoxin interacting protein multiple interactions ISO [Aflatoxin B1 co-treated with aflatoxin B2 co-treated with aflatoxin G1 co-treated with aflatoxin G2] results in increased expression of TXNIP mRNA CTD PMID:31904472 NCBI chr 2:198,683,168...198,686,971
Ensembl chr 2:198,683,159...198,686,974 		JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO aflatoxin G1 results in increased expression of VEGFA protein CTD PMID:25445582 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681 		JBrowse link
Aflatoxin G2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mrpl12 mitochondrial ribosomal protein L12 multiple interactions ISO [Aflatoxin B1 co-treated with aflatoxin B2 co-treated with aflatoxin G1 co-treated with aflatoxin G2] results in decreased expression of MRPL12 mRNA; [Plant Extracts co-treated with Aflatoxin B1 co-treated with aflatoxin B2 co-treated with aflatoxin G1 co-treated with aflatoxin G2] results in decreased expression of MRPL12 mRNA CTD PMID:31904472 NCBI chr10:109,658,032...109,662,535
Ensembl chr10:109,658,032...109,662,535 		JBrowse link
G Mt-atp8 mitochondrially encoded ATP synthase membrane subunit 8 multiple interactions ISO [Aflatoxin B1 co-treated with aflatoxin B2 co-treated with aflatoxin G1 co-treated with aflatoxin G2] results in decreased expression of ATP8 mRNA; [Plant Extracts co-treated with Aflatoxin B1 co-treated with aflatoxin B2 co-treated with aflatoxin G1 co-treated with aflatoxin G2] results in increased expression of ATP8 mRNA CTD PMID:31904472 NCBI chr MT:7,758...7,961
Ensembl chr MT:7,758...7,961 		JBrowse link
G Mt-co1 mitochondrially encoded cytochrome c oxidase I multiple interactions ISO [Aflatoxin B1 co-treated with aflatoxin B2 co-treated with aflatoxin G1 co-treated with aflatoxin G2] results in decreased expression of COX1 mRNA; [Plant Extracts co-treated with Aflatoxin B1 co-treated with aflatoxin B2 co-treated with aflatoxin G1 co-treated with aflatoxin G2] results in decreased expression of COX1 mRNA CTD PMID:31904472 NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867 		JBrowse link
G Mt-co3 mitochondrially encoded cytochrome c oxidase III multiple interactions ISO [Plant Extracts co-treated with Aflatoxin B1 co-treated with aflatoxin B2 co-treated with aflatoxin G1 co-treated with aflatoxin G2] results in increased expression of COX3 mRNA CTD PMID:31904472 NCBI chr MT:8,599...9,382
Ensembl chr MT:8,599...9,382 		JBrowse link
G Mt-nd3 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 3 multiple interactions ISO [Aflatoxin B1 co-treated with aflatoxin B2 co-treated with aflatoxin G1 co-treated with aflatoxin G2] results in increased expression of ND3 mRNA; [Plant Extracts co-treated with Aflatoxin B1 co-treated with aflatoxin B2 co-treated with aflatoxin G1 co-treated with aflatoxin G2] results in increased expression of ND3 mRNA CTD PMID:31904472 NCBI chr MT:9,451...9,798
Ensembl chr MT:9,451...9,798 		JBrowse link
G Mt-nd4 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4 multiple interactions ISO [Aflatoxin B1 co-treated with aflatoxin B2 co-treated with aflatoxin G1 co-treated with aflatoxin G2] results in increased expression of ND4 mRNA; [Plant Extracts co-treated with Aflatoxin B1 co-treated with aflatoxin B2 co-treated with aflatoxin G1 co-treated with aflatoxin G2] results in increased expression of ND4 mRNA CTD PMID:31904472 NCBI chr MT:10,160...11,537
Ensembl chr MT:10,160...11,537 		JBrowse link
G Mt-nd4l mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4L multiple interactions ISO [Aflatoxin B1 co-treated with aflatoxin B2 co-treated with aflatoxin G1 co-treated with aflatoxin G2] results in increased expression of ND4L mRNA; [Plant Extracts co-treated with Aflatoxin B1 co-treated with aflatoxin B2 co-treated with aflatoxin G1 co-treated with aflatoxin G2] results in increased expression of ND4L mRNA CTD PMID:31904472 NCBI chr MT:9,870...10,166
Ensembl chr MT:9,870...10,166 		JBrowse link
G Mt-nd5 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 5 multiple interactions ISO [Aflatoxin B1 co-treated with aflatoxin B2 co-treated with aflatoxin G1 co-treated with aflatoxin G2] results in decreased expression of ND5 mRNA CTD PMID:31904472 NCBI chr MT:11,736...13,565
Ensembl chr MT:11,736...13,565 		JBrowse link
G Osgin1 oxidative stress induced growth inhibitor 1 multiple interactions ISO [Plant Extracts co-treated with Aflatoxin B1 co-treated with aflatoxin B2 co-treated with aflatoxin G1 co-treated with aflatoxin G2] results in decreased expression of OSGIN1 mRNA CTD PMID:31904472 NCBI chr19:52,056,808...52,085,491
Ensembl chr19:52,077,109...52,085,496 		JBrowse link
G Srxn1 sulfiredoxin 1 multiple interactions ISO [Plant Extracts co-treated with Aflatoxin B1 co-treated with aflatoxin B2 co-treated with aflatoxin G1 co-treated with aflatoxin G2] results in decreased expression of SRXN1 mRNA CTD PMID:31904472 NCBI chr 3:147,608,850...147,614,410
Ensembl chr 3:147,609,095...147,632,801 		JBrowse link
G Txnip thioredoxin interacting protein multiple interactions ISO [Aflatoxin B1 co-treated with aflatoxin B2 co-treated with aflatoxin G1 co-treated with aflatoxin G2] results in increased expression of TXNIP mRNA CTD PMID:31904472 NCBI chr 2:198,683,168...198,686,971
Ensembl chr 2:198,683,159...198,686,974 		JBrowse link
auraptene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO aurapten promotes the reaction [ABCB1 protein results in increased hydrolysis of Adenosine Triphosphate]; aurapten promotes the reaction [ABCB1 protein results in increased import of Daunorubicin] CTD PMID:18955043 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515 		JBrowse link
G Ccna2 cyclin A2 affects expression ISO aurapten affects the expression of CCNA2 mRNA CTD PMID:23320178 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214 		JBrowse link
G Ccnb2 cyclin B2 affects expression ISO aurapten affects the expression of CCNB2 mRNA CTD PMID:23320178 NCBI chr 8:76,847,972...76,861,165 JBrowse link
G Cdc45 cell division cycle 45 affects expression ISO aurapten affects the expression of CDC45 mRNA CTD PMID:23320178 NCBI chr11:86,328,785...86,354,099
Ensembl chr11:86,329,012...86,358,453 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 affects expression ISO aurapten affects the expression of CDK1 mRNA CTD PMID:23320178 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549 		JBrowse link
G Cdkn2b cyclin-dependent kinase inhibitor 2B affects expression ISO aurapten affects the expression of CDKN2B mRNA CTD PMID:23320178 NCBI chr 5:107,834,353...107,857,428
Ensembl chr 5:107,845,951...107,858,104 		JBrowse link
G Cdkn2c cyclin-dependent kinase inhibitor 2C affects expression ISO aurapten affects the expression of CDKN2C mRNA CTD PMID:23320178 NCBI chr 5:129,347,731...129,352,886
Ensembl chr 5:129,347,732...129,352,886 		JBrowse link
G Chek1 checkpoint kinase 1 affects expression ISO aurapten affects the expression of CHEK1 mRNA CTD PMID:23320178 NCBI chr 8:39,181,162...39,201,588
Ensembl chr 8:39,181,163...39,243,882 		JBrowse link
G Chek2 checkpoint kinase 2 affects expression ISO aurapten affects the expression of CHEK2 mRNA CTD PMID:23320178 NCBI chr12:51,845,574...51,878,098
Ensembl chr12:51,845,796...51,877,624 		JBrowse link
G Ctnnb1 catenin beta 1 decreases expression EXP aurapten results in decreased expression of CTNNB1 protein mutant form CTD PMID:16012713 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO aurapten inhibits the reaction [DDT results in increased expression of CYP1A1 mRNA]; aurapten inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] CTD PMID:20865247 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 affects expression ISO aurapten affects the expression of DDIT3 mRNA CTD PMID:23320178 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084 		JBrowse link
G Dusp1 dual specificity phosphatase 1 affects expression ISO aurapten affects the expression of DUSP1 mRNA CTD PMID:23320178 NCBI chr10:16,970,642...16,973,425
Ensembl chr10:16,970,626...16,973,418 		JBrowse link
G E2f1 E2F transcription factor 1 affects expression ISO aurapten affects the expression of E2F1 mRNA CTD PMID:23320178 NCBI chr 3:150,062,895...150,073,721
Ensembl chr 3:150,047,826...150,073,721 		JBrowse link
G E2f2 E2F transcription factor 2 affects expression ISO aurapten affects the expression of E2F2 mRNA CTD PMID:23320178 NCBI chr 5:154,516,611...154,540,228
Ensembl chr 5:154,522,119...154,540,265 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha affects expression ISO aurapten affects the expression of GADD45A mRNA CTD PMID:23320178 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit affects expression ISO aurapten affects the expression of JUN mRNA CTD PMID:23320178 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277 		JBrowse link
G Kif20b kinesin family member 20B affects expression ISO aurapten affects the expression of KIF20B mRNA CTD PMID:23320178 NCBI chr 1:253,220,038...253,275,523
Ensembl chr 1:253,221,812...253,275,490 		JBrowse link
G Mcm3 minichromosome maintenance complex component 3 affects expression ISO aurapten affects the expression of MCM3 mRNA CTD PMID:23320178 NCBI chr 9:26,914,057...26,932,201
Ensembl chr 9:26,914,057...26,932,201 		JBrowse link
G Mcm6 minichromosome maintenance complex component 6 affects expression ISO aurapten affects the expression of MCM6 mRNA CTD PMID:23320178 NCBI chr13:45,042,882...45,068,073
Ensembl chr13:45,042,882...45,068,077 		JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 affects response to substance ISO NFE2L2 protein affects the susceptibility to aurapten CTD PMID:19150646 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO aurapten inhibits the reaction [DDT results in increased expression of PTGS2 mRNA]; aurapten inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PTGS2 mRNA] CTD PMID:20865247 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
G Uhrf1 ubiquitin-like with PHD and ring finger domains 1 affects expression ISO aurapten affects the expression of UHRF1 mRNA CTD PMID:23320178 NCBI chr 9:10,738,211...10,758,403
Ensembl chr 9:10,738,222...10,757,954 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO aurapten inhibits the reaction [DDT results in increased expression of VEGFA mRNA]; aurapten inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of VEGFA mRNA] CTD PMID:20865247 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681 		JBrowse link
Biflorin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Braf B-Raf proto-oncogene, serine/threonine kinase affects expression ISO biflorin affects the expression of BRAF mRNA CTD PMID:27079618 NCBI chr 4:67,389,331...67,520,549
Ensembl chr 4:67,396,192...67,520,356 		JBrowse link
G Melk maternal embryonic leucine zipper kinase affects expression ISO biflorin affects the expression of MELK mRNA CTD PMID:27079618 NCBI chr 5:59,783,835...59,844,356
Ensembl chr 5:59,783,890...59,844,356 		JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase affects expression ISO biflorin affects the expression of MGMT mRNA CTD PMID:27079618 NCBI chr 1:209,237,255...209,464,189
Ensembl chr 1:209,237,233...209,464,190 		JBrowse link
G Rad54l RAD54 like affects expression ISO biflorin affects the expression of RAD54L mRNA CTD PMID:27079618 NCBI chr 5:134,948,511...134,978,125
Ensembl chr 5:134,948,512...134,978,125 		JBrowse link
G Tyms thymidylate synthetase affects expression ISO biflorin affects the expression of TYMS mRNA CTD PMID:27079618 NCBI chr 9:121,918,875...121,931,564
Ensembl chr 9:121,918,947...121,931,564 		JBrowse link
chromone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions
increases expression		 ISO benzyloxycarbonyl-valyl-alanyl-aspartyl-fluoromethane inhibits the reaction [4-chromone analog results in increased expression of CASP3 protein modified form] CTD PMID:30256521 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Casp8 caspase 8 multiple interactions
increases expression		 ISO benzyloxycarbonyl-valyl-alanyl-aspartyl-fluoromethane inhibits the reaction [4-chromone analog results in increased expression of CASP8 protein modified form] CTD PMID:30256521 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106 		JBrowse link
G Casp9 caspase 9 multiple interactions
increases expression		 ISO benzyloxycarbonyl-valyl-alanyl-aspartyl-fluoromethane inhibits the reaction [4-chromone analog results in increased expression of CASP9 protein modified form] CTD PMID:30256521 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778 		JBrowse link
G H2ax H2A.X variant histone increases expression ISO 4-chromone analog results in increased expression of H2AX protein modified form CTD PMID:30256521 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases expression
multiple interactions		 ISO 4-chromone analog results in increased expression of PARP1 protein modified form
Acetylcysteine inhibits the reaction [4-chromone analog results in increased expression of PARP1 protein modified form]; benzyloxycarbonyl-valyl-alanyl-aspartyl-fluoromethane inhibits the reaction [4-chromone analog results in increased expression of PARP1 protein modified form]		 CTD PMID:30256521 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716 		JBrowse link
chromones term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 affects binding
multiple interactions		 ISO [Chromones analog binds to cuprous chloride] which binds to AKT1 protein
[Chromones analog binds to cuprous chloride] which results in decreased activity of AKT1 protein		 CTD PMID:16789737 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258 		JBrowse link
G Calr calreticulin increases activity ISO Chromones results in increased activity of CALR protein CTD PMID:20188080 NCBI chr19:25,956,771...25,961,666
Ensembl chr19:25,956,771...25,961,666 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions
increases expression		 ISO N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [Chromones analog results in increased expression of MAPK9 protein modified form] CTD PMID:22583868 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355 		JBrowse link
cloricromen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Icam1 intercellular adhesion molecule 1 multiple interactions EXP cloricromen inhibits the reaction [Streptozocin results in increased expression of ICAM1 protein] CTD PMID:19279317 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP cloricromen inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA] CTD PMID:15322736 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190 		JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions EXP cloricromen inhibits the reaction [Streptozocin results in increased expression of NOS3 protein] CTD PMID:19279317 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression		 EXP cloricromen inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; cloricromen inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; cloricromen inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; cloricromen inhibits the reaction [Streptozocin results in increased expression of TNF protein]
cloricromen results in decreased expression of TNF protein		 CTD PMID:11343695, PMID:15322736, PMID:16572308, PMID:19279317 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions EXP cloricromen inhibits the reaction [Streptozocin results in increased expression of VEGFA protein] CTD PMID:19279317 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681 		JBrowse link
Coumachlor term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Vkorc1 vitamin K epoxide reductase complex, subunit 1 multiple interactions
decreases activity		 ISO coumachlor inhibits the reaction [VKORC1 protein results in increased reduction of Vitamin K 1]; coumachlor inhibits the reaction [VKORC1 protein results in increased reduction of vitamin K1 oxide]
coumachlor results in decreased activity of VKORC1 protein		 CTD PMID:29581108 NCBI chr 1:199,338,785...199,341,306
Ensembl chr 1:199,337,138...199,341,302 		JBrowse link
G Vkorc1l1 vitamin K epoxide reductase complex, subunit 1-like 1 decreases activity
multiple interactions		 ISO coumachlor results in decreased activity of VKORC1L1 protein
coumachlor inhibits the reaction [VKORC1L1 protein results in increased reduction of Vitamin K 1]; coumachlor inhibits the reaction [VKORC1L1 protein results in increased reduction of vitamin K1 oxide]		 CTD PMID:29581108 NCBI chr12:30,218,825...30,268,990
Ensembl chr12:30,222,701...30,268,990 		JBrowse link
coumaphos term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity ISO Coumaphos metabolite results in decreased activity of ACHE protein; Coumaphos results in decreased activity of ACHE protein CTD PMID:30625376 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753 		JBrowse link
G Gpat3 glycerol-3-phosphate acyltransferase 3 increases expression ISO Coumaphos results in increased expression of GPAT3 mRNA CTD PMID:26198647 NCBI chr14:10,343,287...10,396,565
Ensembl chr14:10,343,282...10,395,047 		JBrowse link
G Lif LIF, interleukin 6 family cytokine increases expression ISO Coumaphos results in increased expression of LIF mRNA CTD PMID:26198647 NCBI chr14:84,482,652...84,500,574
Ensembl chr14:84,482,674...84,500,642 		JBrowse link
G Rara retinoic acid receptor, alpha increases activity ISO Coumaphos results in increased activity of RARA protein CTD PMID:20143881 NCBI chr10:86,838,819...86,884,224
Ensembl chr10:86,860,685...86,884,210 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO Coumaphos results in increased expression of SLC7A11 mRNA CTD PMID:26198647 NCBI chr 2:139,453,774...139,528,479
Ensembl chr 2:139,453,774...139,528,162 		JBrowse link
coumarin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aass aminoadipate-semialdehyde synthase decreases expression EXP coumarin results in decreased expression of AASS mRNA CTD PMID:18480146 NCBI chr 4:50,152,005...50,208,935
Ensembl chr 4:50,152,452...50,200,328 		JBrowse link
G Abcb11 ATP binding cassette subfamily B member 11 affects expression EXP coumarin affects the expression of ABCB11 mRNA CTD PMID:16963487 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression EXP coumarin results in increased expression of ABCC3 mRNA CTD PMID:18480146 NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109 		JBrowse link
G Acaa1a acetyl-CoA acyltransferase 1A increases expression EXP coumarin results in increased expression of ACAA1 mRNA CTD PMID:18480146 NCBI chr 8:128,027,880...128,036,471
Ensembl chr 8:128,027,958...128,036,236 		JBrowse link
G Acaa2 acetyl-CoA acyltransferase 2 affects expression EXP coumarin affects the expression of ACAA2 mRNA CTD PMID:16963487 NCBI chr18:70,733,872...70,762,395
Ensembl chr18:70,733,872...70,762,395 		JBrowse link
G Ache acetylcholinesterase multiple interactions ISO coumarin inhibits the reaction [Dichlorvos results in increased phosphorylation of ACHE protein]; coumarin inhibits the reaction [haloxon results in increased phosphorylation of ACHE protein]; coumarin inhibits the reaction [Paraoxon results in increased phosphorylation of ACHE protein] CTD PMID:10421444 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753 		JBrowse link
G Acly ATP citrate lyase affects expression EXP coumarin affects the expression of ACLY mRNA CTD PMID:16963487 NCBI chr10:88,392,248...88,442,845
Ensembl chr10:88,392,248...88,442,845 		JBrowse link
G Aco1 aconitase 1 affects expression EXP coumarin affects the expression of ACO1 mRNA CTD PMID:16963487 NCBI chr 5:56,425,076...56,481,218
Ensembl chr 5:56,425,024...56,481,218 		JBrowse link
G Acot4 acyl-CoA thioesterase 4 increases expression EXP coumarin results in increased expression of ACOT4 mRNA CTD PMID:18480146 NCBI chr 6:107,517,668...107,522,952
Ensembl chr 6:107,517,668...107,522,952 		JBrowse link
G Acsm1 acyl-CoA synthetase medium-chain family member 1 increases expression ISO coumarin results in increased expression of ACSM1 mRNA CTD PMID:17311802 NCBI chr 1:189,359,374...189,395,277
Ensembl chr 1:189,289,957...189,395,276 		JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 decreases expression ISO coumarin analog results in decreased expression of AIFM1 mRNA CTD PMID:32578917 NCBI chr  X:135,304,063...135,343,062
Ensembl chr  X:135,304,066...135,343,087 		JBrowse link
G Akr1b8 aldo-keto reductase family 1, member B8 increases expression EXP coumarin results in increased expression of AKR1B8 mRNA CTD PMID:18480146 NCBI chr 4:61,772,064...61,784,637
Ensembl chr 4:61,771,970...61,828,657 		JBrowse link
G Akr1c1 aldo-keto reductase family 1, member C1 decreases expression EXP coumarin results in decreased expression of AKR1C6 mRNA CTD PMID:18480146 NCBI chr17:69,441,253...69,460,334
Ensembl chr17:69,441,223...69,460,321 		JBrowse link
G Akr1d1 aldo-keto reductase family 1, member D1 affects expression EXP coumarin affects the expression of AKR1D1 mRNA CTD PMID:16963487 NCBI chr 4:65,110,706...65,143,930
Ensembl chr 4:65,110,746...65,143,941 		JBrowse link
G Akr7a3 aldo-keto reductase family 7 member A3 increases expression EXP coumarin results in increased expression of AKR7A3 mRNA CTD PMID:18480146 NCBI chr 5:157,801,120...157,813,756
Ensembl chr 5:157,801,163...157,813,756 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO coumarin analog results in decreased expression of and results in decreased phosphorylation of AKT1 protein CTD PMID:32578917 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258 		JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 increases expression EXP coumarin results in increased expression of ALDH1A1 mRNA CTD PMID:18480146 NCBI chr 1:238,222,689...238,264,381
Ensembl chr 1:238,222,521...238,264,330 		JBrowse link
G Alox5 arachidonate 5-lipoxygenase increases expression EXP coumarin results in increased expression of ALOX5 mRNA CTD PMID:18480146 NCBI chr 4:148,398,004...148,446,308
Ensembl chr 4:148,398,892...148,446,303 		JBrowse link
G Anxa7 annexin A7 increases expression EXP coumarin results in increased expression of ANXA7 mRNA CTD PMID:18480146 NCBI chr15:4,254,470...4,281,296
Ensembl chr15:4,254,499...4,281,287 		JBrowse link
G Apbb3 amyloid beta precursor protein binding family B member 3 decreases expression EXP coumarin results in decreased expression of APBB3 mRNA CTD PMID:18480146 NCBI chr18:29,497,865...29,504,995
Ensembl chr18:29,497,863...29,504,995 		JBrowse link
G Apcs amyloid P component, serum decreases expression EXP coumarin results in decreased expression of APCS mRNA CTD PMID:18480146 NCBI chr13:91,426,621...91,427,417
Ensembl chr13:91,426,479...91,427,575 		JBrowse link
G Arg1 arginase 1 affects expression EXP coumarin affects the expression of ARG1 mRNA CTD PMID:16963487 NCBI chr 1:21,525,421...21,537,872
Ensembl chr 1:21,525,421...21,537,863 		JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) increases expression EXP coumarin results in increased expression of ASNS mRNA CTD PMID:18480146 NCBI chr 4:33,742,876...33,761,106
Ensembl chr 4:33,743,364...33,761,163 		JBrowse link
G Atp5if1 ATP synthase inhibitory factor subunit 1 increases expression EXP coumarin results in increased expression of ATPIF1 mRNA CTD PMID:18480146 NCBI chr 5:150,719,570...150,723,287
Ensembl chr 5:150,719,569...150,723,321 		JBrowse link
G Atrn attractin decreases expression EXP coumarin results in decreased expression of ATRN mRNA CTD PMID:18480146 NCBI chr 3:123,434,409...123,567,922
Ensembl chr 3:123,434,409...123,567,918 		JBrowse link
G Avpr1a arginine vasopressin receptor 1A decreases expression EXP coumarin results in decreased expression of AVPR1A mRNA CTD PMID:18480146 NCBI chr 7:67,341,366...67,345,290
Ensembl chr 7:67,341,080...67,345,308 		JBrowse link
G Azgp1 alpha-2-glycoprotein 1, zinc-binding affects expression EXP coumarin affects the expression of AZGP1 mRNA CTD PMID:16963487 NCBI chr12:19,196,565...19,203,094
Ensembl chr12:19,196,611...19,202,647 		JBrowse link
G Bad BCL2-associated agonist of cell death increases expression ISO coumarin analog results in increased expression of BAD mRNA CTD PMID:32578917 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases expression ISO coumarin analog results in increased expression of BAK1 protein CTD PMID:31199928 NCBI chr20:5,609,620...5,618,899
Ensembl chr20:5,609,625...5,618,260 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO coumarin analog results in increased expression of BAX mRNA; coumarin results in increased expression of BAX protein CTD PMID:15964220, PMID:32578917 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Bbc3 Bcl-2 binding component 3 increases expression ISO coumarin analog results in increased expression of BBC3 protein CTD PMID:31199928 NCBI chr 1:78,261,491...78,267,802 JBrowse link
G Bbox1 gamma-butyrobetaine hydroxylase 1 decreases expression EXP coumarin results in decreased expression of BBOX1 mRNA CTD PMID:18480146 NCBI chr 3:101,425,684...101,474,848
Ensembl chr 3:101,427,055...101,474,890 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO coumarin analog results in decreased expression of BCL2 mRNA; coumarin results in decreased expression of BCL2 protein CTD PMID:15964220, PMID:32578917 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Bhlha15 basic helix-loop-helix family, member a15 increases expression EXP coumarin results in increased expression of BHLHA15 mRNA CTD PMID:18480146 NCBI chr12:12,403,385...12,409,103
Ensembl chr12:12,403,385...12,407,561 		JBrowse link
G Bhmt betaine-homocysteine S-methyltransferase decreases expression
affects expression		 EXP coumarin results in decreased expression of BHMT mRNA
coumarin affects the expression of BHMT mRNA		 CTD PMID:16963487, PMID:18480146 NCBI chr 2:23,236,573...23,256,158
Ensembl chr 2:23,236,575...23,256,158 		JBrowse link
G Bid BH3 interacting domain death agonist increases expression ISO coumarin analog results in increased expression of BID mRNA CTD PMID:32578917 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO coumarin analog results in decreased expression of BIRC5 mRNA CTD PMID:32578917 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413 		JBrowse link
G Ca3 carbonic anhydrase 3 decreases expression EXP coumarin results in decreased expression of CA3 mRNA CTD PMID:18480146 NCBI chr 2:88,126,519...88,136,063
Ensembl chr 2:88,126,667...88,135,410 		JBrowse link
G Capn1 calpain 1 decreases expression ISO coumarin analog results in decreased expression of CAPN1 mRNA CTD PMID:32578917 NCBI chr 1:221,346,081...221,370,965
Ensembl chr 1:221,346,066...221,370,322 		JBrowse link
G Car1 carbonic anhydrase 1 decreases activity ISO coumarin results in decreased activity of CA1 protein CTD PMID:22077347 NCBI chr 2:88,185,204...88,227,486
Ensembl chr 2:88,217,188...88,227,479 		JBrowse link
G Car2 carbonic anhydrase 2 increases expression
decreases activity		 EXP
ISO		 coumarin results in increased expression of CA2 mRNA
coumarin results in decreased activity of CA2 protein		 CTD PMID:18480146, PMID:22077347 NCBI chr 2:88,097,740...88,112,868
Ensembl chr 2:88,097,720...88,113,029 		JBrowse link
G Casp3 caspase 3 increases cleavage
increases expression		 ISO coumarin analog results in increased cleavage of CASP3 protein
coumarin analog results in increased expression of CASP3 mRNA		 CTD PMID:32578917 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Casp8 caspase 8 increases expression ISO coumarin analog results in increased expression of CASP8 mRNA CTD PMID:32578917 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106 		JBrowse link
G Casp9 caspase 9 increases expression ISO coumarin analog results in increased expression of CASP9 mRNA CTD PMID:32578917 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778 		JBrowse link
G Cat catalase multiple interactions
decreases activity		 EXP
ISO		 coumarin inhibits the reaction [[Niacinamide co-treated with Streptozocin] results in decreased activity of CAT protein]
coumarin analog results in decreased activity of CAT protein		 CTD PMID:21630391, PMID:32578917 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058 		JBrowse link
G Cbr1 carbonyl reductase 1 increases expression EXP coumarin results in increased expression of CBR1 mRNA CTD PMID:18480146 NCBI chr11:33,813,041...33,815,418
Ensembl chr11:33,845,463...33,847,793 		JBrowse link
G Ccnb2 cyclin B2 decreases expression EXP coumarin results in decreased expression of CCNB2 mRNA CTD PMID:18480146 NCBI chr 8:76,847,972...76,861,165 JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO coumarin analog results in decreased expression of CCND1 mRNA CTD PMID:32578917 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325 		JBrowse link
G Ccne1 cyclin E1 increases expression
decreases expression		 EXP
ISO		 coumarin results in increased expression of CCNE1 mRNA
coumarin analog results in decreased expression of CCNE1 mRNA		 CTD PMID:18480146, PMID:32578917 NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980 		JBrowse link
G Ccne2 cyclin E2 increases expression EXP coumarin results in increased expression of CCNE2 mRNA CTD PMID:18480146 NCBI chr 5:24,434,077...24,446,406
Ensembl chr 5:24,434,872...24,446,406 		JBrowse link
G Cdh1 cadherin 1 increases expression ISO coumarin analog results in increased expression of CDH1 mRNA; coumarin analog results in increased expression of CDH1 protein CTD PMID:32578917 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395 		JBrowse link
G Cdh2 cadherin 2 decreases expression ISO coumarin analog results in decreased expression of CDH2 mRNA CTD PMID:32578917 NCBI chr18:8,146,971...8,366,037
Ensembl chr18:8,146,971...8,360,684 		JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO coumarin analog results in decreased expression of CDK2 mRNA CTD PMID:32578917 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO coumarin analog results in decreased expression of CDK4 mRNA CTD PMID:32578917 NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO coumarin analog results in increased expression of CDKN1A mRNA CTD PMID:32578917 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864 		JBrowse link
G Cdkn3 cyclin-dependent kinase inhibitor 3 decreases expression EXP coumarin results in decreased expression of CDKN3 mRNA CTD PMID:18480146 NCBI chr15:23,553,171...23,564,538
Ensembl chr15:23,553,128...23,564,535 		JBrowse link
G Cdo1 cysteine dioxygenase type 1 affects expression EXP coumarin affects the expression of CDO1 mRNA CTD PMID:16963487 NCBI chr18:40,702,027...40,716,901
Ensembl chr18:40,701,984...40,716,686 		JBrowse link
G Ces1d carboxylesterase 1D increases expression ISO coumarin results in increased expression of CES1 mRNA CTD PMID:17311802 NCBI chr19:15,195,514...15,239,827
Ensembl chr19:15,033,108...15,239,821 		JBrowse link
G Cisd3 CDGSH iron sulfur domain 3 increases expression EXP coumarin results in increased expression of CISD3 mRNA CTD PMID:18480146 NCBI chr10:85,628,579...85,631,656
Ensembl chr10:85,628,491...85,631,657 		JBrowse link
G Cldn3 claudin 3 decreases expression ISO coumarin analog results in decreased expression of CLDN3 mRNA CTD PMID:32578917 NCBI chr12:21,831,341...21,832,813
Ensembl chr12:21,831,342...21,832,813 		JBrowse link
G Cldn4 claudin 4 decreases expression ISO coumarin analog results in decreased expression of CLDN4 mRNA CTD PMID:32578917 NCBI chr12:24,761,210...24,763,008
Ensembl chr12:24,761,210...24,763,005 		JBrowse link
G Coq6 coenzyme Q6 monooxygenase increases expression EXP coumarin results in increased expression of COQ6 mRNA CTD PMID:18480146 NCBI chr 6:108,076,393...108,087,782
Ensembl chr 6:108,076,306...108,087,696 		JBrowse link
G Creg1 cellular repressor of E1A-stimulated genes 1 increases expression EXP coumarin results in increased expression of CREG mRNA CTD PMID:18480146 NCBI chr13:83,972,186...83,984,675
Ensembl chr13:83,972,212...83,984,675 		JBrowse link
G Creld2 cysteine-rich with EGF-like domains 2 increases expression EXP coumarin results in increased expression of CRELD2 mRNA CTD PMID:18480146 NCBI chr 7:129,812,746...129,819,641
Ensembl chr 7:129,812,789...129,819,634 		JBrowse link
G Cryab crystallin, alpha B decreases expression EXP coumarin results in decreased expression of CRYAB mRNA CTD PMID:18480146 NCBI chr 8:55,178,543...55,182,546
Ensembl chr 8:55,178,289...55,182,545 		JBrowse link
G Cryl1 crystallin, lambda 1 increases expression EXP coumarin results in increased expression of CRYL1 mRNA CTD PMID:18480146 NCBI chr15:37,543,727...37,663,586
Ensembl chr15:37,543,727...37,663,584 		JBrowse link
G Csad cysteine sulfinic acid decarboxylase decreases expression EXP coumarin results in decreased expression of CSAD mRNA CTD PMID:18480146 NCBI chr 7:143,781,520...143,810,880
Ensembl chr 7:143,781,702...143,793,970 		JBrowse link
G Csrp1 cysteine and glycine-rich protein 1 decreases expression EXP coumarin results in decreased expression of CSRP1 mRNA CTD PMID:18480146 NCBI chr13:52,553,843...52,575,054
Ensembl chr13:52,553,775...52,575,051 		JBrowse link
G Ctf1 cardiotrophin 1 increases expression EXP coumarin results in increased expression of CTF1 mRNA CTD PMID:18480146 NCBI chr 1:199,162,319...199,168,296
Ensembl chr 1:199,163,086...199,168,296 		JBrowse link
G Cth cystathionine gamma-lyase affects expression EXP coumarin affects the expression of CTH mRNA CTD PMID:16963487 NCBI chr 2:264,266,959...264,293,040
Ensembl chr 2:264,266,984...264,293,046 		JBrowse link
G Ctnnb1 catenin beta 1 decreases expression ISO coumarin analog results in decreased expression of CTNNB1 mRNA CTD PMID:32578917 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372 		JBrowse link
G Ctsb cathepsin B increases expression ISO coumarin analog results in increased expression of CTSB mRNA CTD PMID:32578917 NCBI chr15:46,316,741...46,337,613
Ensembl chr15:46,316,741...46,337,612 		JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 decreases expression EXP coumarin results in decreased expression of CXCL12 mRNA CTD PMID:18480146 NCBI chr 4:149,261,044...149,273,891
Ensembl chr 4:149,261,044...149,273,891 		JBrowse link
G Cyb561 cytochrome b-561 increases expression EXP coumarin results in increased expression of CYB561 mRNA CTD PMID:18480146 NCBI chr10:94,136,993...94,147,567
Ensembl chr10:94,136,993...94,147,621 		JBrowse link
G Cycs cytochrome c, somatic increases expression ISO coumarin analog results in increased expression of CYCS mRNA CTD PMID:32578917 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases expression
affects expression		 EXP coumarin results in decreased expression of CYP1A2 mRNA
coumarin affects the expression of CYP1A2 mRNA		 CTD PMID:16963487, PMID:18480146 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301 		JBrowse link
G Cyp2a1 cytochrome P450, family 2, subfamily a, polypeptide 1 increases hydroxylation EXP CYP2A6 protein results in increased hydroxylation of coumarin CTD PMID:12919726 NCBI chr 1:83,711,223...83,725,222
Ensembl chr 1:83,653,234...83,766,484 		JBrowse link
G Cyp2a3 cytochrome P450, family 2, subfamily a, polypeptide 3 affects metabolic processing ISO CYP2A5 protein affects the metabolism of coumarin CTD PMID:10646973 NCBI chr 1:83,653,248...83,662,118
Ensembl chr 1:83,653,234...83,766,484 		JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 decreases expression EXP coumarin results in decreased expression of CYP2C mRNA CTD PMID:18480146 NCBI chr 1:257,676,172...258,004,428
Ensembl chr 1:257,970,345...258,004,434 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 affects localization EXP coumarin affects the localization of CYP2E1 protein CTD PMID:28803882 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 affects expression EXP coumarin affects the expression of CYP3A2 mRNA CTD PMID:16963487 NCBI chr12:11,641,500...11,677,818
Ensembl chr12:11,655,402...11,733,136 		JBrowse link
G Cyp51 cytochrome P450, family 51 decreases expression EXP coumarin results in decreased expression of CYP51 mRNA CTD PMID:18480146 NCBI chr 4:27,175,564...27,194,018
Ensembl chr 4:27,175,243...27,194,018 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 decreases expression EXP coumarin results in decreased expression of CYP7A1 mRNA CTD PMID:18480146 NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431 		JBrowse link
G Ddit4l DNA-damage-inducible transcript 4-like increases expression EXP coumarin results in increased expression of DDIT4L mRNA CTD PMID:18480146 NCBI chr 2:242,882,219...242,885,088
Ensembl chr 2:242,882,306...242,885,131 		JBrowse link
G Ddost dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit increases expression EXP coumarin results in increased expression of DDOST mRNA CTD PMID:18480146 NCBI chr 5:156,668,924...156,676,036
Ensembl chr 5:156,668,712...156,676,035 		JBrowse link
G Ddx31 DEAD-box helicase 31 decreases expression EXP coumarin results in decreased expression of DDX31 mRNA CTD PMID:18480146 NCBI chr 3:7,422,871...7,488,299
Ensembl chr 3:7,422,820...7,488,617 		JBrowse link
G Dnajb11 DnaJ heat shock protein family (Hsp40) member B11 increases expression EXP coumarin results in increased expression of DNAJB11 mRNA CTD PMID:18480146 NCBI chr11:81,741,342...81,757,806
Ensembl chr11:81,741,297...81,757,813 		JBrowse link
G Dnajb9 DnaJ heat shock protein family (Hsp40) member B9 affects expression EXP coumarin affects the expression of DNAJB9 mRNA CTD PMID:16963487 NCBI chr 6:64,165,913...64,170,122
Ensembl chr 6:64,165,913...64,170,151 		JBrowse link
G Dnajc3 DnaJ heat shock protein family (Hsp40) member C3 increases expression EXP coumarin results in increased expression of DNAJC3 mRNA CTD PMID:18480146 NCBI chr15:104,186,918...104,226,236
Ensembl chr15:104,186,792...104,226,329 		JBrowse link
G Dscc1 DNA replication and sister chromatid cohesion 1 increases expression EXP coumarin results in increased expression of DSCC1 mRNA CTD PMID:18480146 NCBI chr 7:94,759,076...94,774,787
Ensembl chr 7:94,758,800...94,774,569 		JBrowse link
G Eci1 enoyl-CoA delta isomerase 1 affects expression EXP coumarin affects the expression of ECI1 mRNA CTD PMID:16963487 NCBI chr10:13,797,573...13,810,918
Ensembl chr10:13,797,562...13,810,913 		JBrowse link
G Eef1e1 eukaryotic translation elongation factor 1 epsilon 1 increases expression EXP coumarin results in increased expression of EEF1E1 mRNA CTD PMID:18480146 NCBI chr17:26,785,017...26,795,723
Ensembl chr17:26,785,029...26,797,161 		JBrowse link
G Ell3 elongation factor for RNA polymerase II 3 increases expression EXP coumarin results in increased expression of ELL3 mRNA CTD PMID:18480146 NCBI chr 3:113,400,395...113,405,869
Ensembl chr 3:113,401,734...113,405,829 		JBrowse link
G Eme2 essential meiotic structure-specific endonuclease subunit 2 increases expression EXP coumarin results in increased expression of EME2 mRNA CTD PMID:18480146 NCBI chr10:14,253,552...14,257,017
Ensembl chr10:14,254,252...14,256,930 		JBrowse link
G Ephx1 epoxide hydrolase 1 increases expression ISO coumarin results in increased expression of EPHX1 mRNA CTD PMID:17311802 NCBI chr13:99,271,390...99,300,580
Ensembl chr13:99,271,366...99,300,579 		JBrowse link
G F9 coagulation factor IX increases response to substance ISO F9 exon polymorphism results in increased susceptibility to coumarin; F9 protein mutant form results in increased susceptibility to coumarin CTD PMID:11307814 NCBI chr  X:143,097,507...143,141,791
Ensembl chr  X:143,097,525...143,141,794 		JBrowse link
G Fads1 fatty acid desaturase 1 decreases expression EXP coumarin results in decreased expression of FADS1 mRNA CTD PMID:18480146 NCBI chr 1:226,234,034...226,249,118
Ensembl chr 1:226,234,074...226,249,138 		JBrowse link
G Fam111a FAM111 trypsin like peptidase A increases expression EXP coumarin results in increased expression of FAM111A mRNA CTD PMID:18480146 NCBI chr 1:229,003,778...229,019,532
Ensembl chr 1:229,003,961...229,019,527 		JBrowse link
G Fasn fatty acid synthase affects expression EXP coumarin affects the expression of FASN mRNA CTD PMID:16963487 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901 		JBrowse link
G Fen1 flap structure-specific endonuclease 1 increases expression EXP coumarin results in increased expression of FEN1 mRNA CTD PMID:18480146 NCBI chr 1:226,251,516...226,256,160
Ensembl chr 1:226,251,518...226,255,886 		JBrowse link
G Fgg fibrinogen gamma chain affects expression EXP coumarin affects the expression of FGG mRNA CTD PMID:16963487 NCBI chr 2:181,987,080...181,994,523
Ensembl chr 2:181,987,217...181,994,514 		JBrowse link
G Fggy FGGY carbohydrate kinase domain containing decreases expression EXP coumarin results in decreased expression of FGGY mRNA CTD PMID:18480146 NCBI chr 5:114,516,860...114,901,571
Ensembl chr 5:114,516,889...114,901,564 		JBrowse link
G Fkbp11 FKBP prolyl isomerase 11 increases expression EXP coumarin results in increased expression of FKBP11 mRNA CTD PMID:18480146 NCBI chr 7:140,398,253...140,402,664
Ensembl chr 7:140,398,199...140,437,467 		JBrowse link
G Fmo1 flavin containing dimethylaniline monoxygenase 1 decreases expression EXP coumarin results in decreased expression of FMO1 mRNA CTD PMID:18480146 NCBI chr13:80,712,885...80,745,095
Ensembl chr13:80,712,882...80,745,347 		JBrowse link
G Gas5 growth arrest specific 5 increases expression EXP coumarin results in increased expression of GAS5 mRNA CTD PMID:18480146 NCBI chr13:78,852,523...78,855,844 JBrowse link
G Gckr glucokinase regulator decreases expression EXP coumarin results in decreased expression of GCKR mRNA CTD PMID:18480146 NCBI chr 6:26,355,296...26,385,761
Ensembl chr 6:26,355,296...26,385,761 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression EXP coumarin results in increased expression of GCLC mRNA CTD PMID:18480146 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression EXP coumarin results in increased expression of GCLM mRNA CTD PMID:18480146 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874 		JBrowse link
G Gjb2 gap junction protein, beta 2 increases expression EXP coumarin results in increased expression of GJB2 mRNA CTD PMID:18480146 NCBI chr15:37,377,313...37,394,494
Ensembl chr15:37,377,316...37,383,277 		JBrowse link
G Gk glycerol kinase decreases expression EXP coumarin results in decreased expression of GK mRNA CTD PMID:18480146 NCBI chr  X:54,227,291...54,303,897
Ensembl chr  X:54,227,397...54,303,864 		JBrowse link
G Glb1 galactosidase, beta 1 increases expression EXP coumarin results in increased expression of GLB1 mRNA CTD PMID:18480146 NCBI chr 8:122,439,328...122,511,939
Ensembl chr 8:122,439,328...122,511,939 		JBrowse link
G Gldc glycine decarboxylase decreases expression EXP coumarin results in decreased expression of GLDC mRNA CTD PMID:18480146 NCBI chr 1:248,295,140...248,377,122
Ensembl chr 1:248,297,331...248,377,093 		JBrowse link
G Gpr108 G protein-coupled receptor 108 decreases expression EXP coumarin results in decreased expression of GPR108 mRNA CTD PMID:18480146 NCBI chr 9:9,704,300...9,714,767
Ensembl chr 9:9,704,346...9,714,755 		JBrowse link
G Gpx1 glutathione peroxidase 1 affects expression EXP coumarin affects the expression of GPX1 mRNA CTD PMID:16963487 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522 		JBrowse link
G Gsr glutathione-disulfide reductase increases expression EXP coumarin results in increased expression of GSR mRNA CTD PMID:18480146 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361 		JBrowse link
G Gsta2 glutathione S-transferase alpha 2 increases expression ISO
EXP		 coumarin results in increased expression of GSTA1 protein; coumarin results in increased expression of GSTA2 protein
coumarin results in increased expression of GSTA3 protein		 CTD PMID:9794803, PMID:11309284 NCBI chr 8:85,640,081...85,645,621 JBrowse link
G Gsta3 glutathione S-transferase alpha 3 increases expression ISO coumarin results in increased expression of GSTA3 protein CTD PMID:11309284 NCBI chr 9:27,357,490...27,417,023
Ensembl chr 9:27,402,381...27,417,023 		JBrowse link
G Gsta5 glutathione S-transferase alpha 5 increases expression EXP coumarin results in increased expression of GSTA5 protein CTD PMID:9794803 NCBI chr 8:85,553,659...85,564,914
Ensembl chr 8:85,553,734...85,565,179 		JBrowse link
G Gsta6 glutathione S-transferase alpha 6 increases expression ISO coumarin results in increased expression of GSTA1 protein; coumarin results in increased expression of GSTA2 protein CTD PMID:11309284 NCBI chr 9:27,475,273...27,533,939
Ensembl chr 9:27,475,273...27,511,176 		JBrowse link
G Gstm5 glutathione S-transferase, mu 5 increases expression EXP
ISO		 coumarin results in increased expression of GSTM3 protein
coumarin results in increased expression of GSTM5 protein		 CTD PMID:9794803, PMID:11309284 NCBI chr 2:210,685,338...210,688,133
Ensembl chr 2:210,685,197...210,688,272 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 increases expression ISO
EXP		 coumarin results in increased expression of GSTP1 protein CTD PMID:9794803, PMID:11309284 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147 		JBrowse link
G Gstt1 glutathione S-transferase theta 1 increases expression EXP coumarin results in increased expression of GSTT1 mRNA; coumarin results in increased expression of GSTT1 protein CTD PMID:9794803, PMID:9855024, PMID:10413528 NCBI chr20:13,799,102...13,816,527
Ensembl chr20:13,799,102...13,816,526 		JBrowse link
G Hal histidine ammonia lyase decreases expression EXP coumarin results in decreased expression of HAL mRNA CTD PMID:18480146 NCBI chr 7:34,326,087...34,356,413
Ensembl chr 7:34,326,087...34,356,413 		JBrowse link
G Hao2 hydroxyacid oxidase 2 decreases expression EXP coumarin results in decreased expression of HAO2 mRNA CTD PMID:18480146 NCBI chr 2:200,785,492...200,808,868
Ensembl chr 2:200,778,122...200,808,857 		JBrowse link
G Hba-a2 hemoglobin alpha, adult chain 2 multiple interactions EXP coumarin inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased glycosylation of HBA1 protein] CTD PMID:19647726 NCBI chr10:15,589,364...15,590,207
Ensembl chr10:15,589,364...15,590,220 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases expression ISO coumarin analog results in increased expression of HIF1A mRNA CTD PMID:32578917 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase increases expression EXP coumarin results in increased expression of HMGCR mRNA CTD PMID:18480146 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654 		JBrowse link
G Hsd17b1 hydroxysteroid (17-beta) dehydrogenase 1 multiple interactions ISO coumarin analog inhibits the reaction [[HSD17B1 protein co-treated with NADP] results in increased reduction of Estrone] CTD PMID:21232530 NCBI chr10:88,987,558...88,989,758
Ensembl chr10:88,987,558...88,989,757 		JBrowse link
G Hsp90b1 heat shock protein 90 beta family member 1 increases expression EXP coumarin results in increased expression of HSP90B1 mRNA CTD PMID:18480146 NCBI chr 7:27,226,570...27,240,533
Ensembl chr 7:27,226,569...27,240,533 		JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B increases expression EXP coumarin results in increased expression of HSPA1B mRNA CTD PMID:18480146 NCBI chr20:4,877,638...4,880,112
Ensembl chr20:2,699,712...2,701,815 		JBrowse link
G Hyou1 hypoxia up-regulated 1 increases expression EXP coumarin results in increased expression of HYOU1 mRNA CTD PMID:18480146 NCBI chr 8:48,699,796...48,711,912
Ensembl chr 8:48,699,769...48,711,910 		JBrowse link
G Igfals insulin-like growth factor binding protein, acid labile subunit decreases expression EXP coumarin results in decreased expression of IGFALS mRNA CTD PMID:18480146 NCBI chr10:14,240,308...14,243,554
Ensembl chr10:14,240,219...14,243,597 		JBrowse link
G Il1b interleukin 1 beta increases expression
decreases expression		 EXP
ISO		 coumarin results in increased expression of IL1B mRNA
coumarin analog results in decreased expression of IL1B protein		 CTD PMID:15135310, PMID:32578917 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Il6 interleukin 6 increases expression
decreases expression		 EXP
ISO		 coumarin results in increased expression of IL6 mRNA
coumarin analog results in decreased expression of IL6 mRNA; coumarin analog results in decreased expression of IL6 protein		 CTD PMID:15135310, PMID:32578917 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Isyna1 inositol-3-phosphate synthase 1 increases expression EXP coumarin results in increased expression of ISYNA1 mRNA CTD PMID:18480146 NCBI chr16:20,589,497...20,592,333
Ensembl chr16:20,589,481...20,592,449 		JBrowse link
G Josd2 Josephin domain containing 2 increases expression EXP coumarin results in increased expression of JOSD2 mRNA CTD PMID:18480146 NCBI chr 1:100,473,426...100,477,352
Ensembl chr 1:100,473,643...100,477,351 		JBrowse link
G Kcnk2 potassium two pore domain channel subfamily K member 2 increases expression EXP coumarin results in increased expression of KCNK2 mRNA CTD PMID:18480146 NCBI chr13:107,690,111...107,886,476
Ensembl chr13:107,690,087...107,886,476 		JBrowse link
G Kdr kinase insert domain receptor increases expression ISO coumarin analog results in increased expression of KDR mRNA CTD PMID:32578917 NCBI chr14:34,727,677...34,787,127
Ensembl chr14:34,727,623...34,787,183 		JBrowse link
G Kif20a kinesin family member 20A decreases expression EXP coumarin results in decreased expression of KIF20A mRNA CTD PMID:18480146 NCBI chr18:27,424,328...27,432,814
Ensembl chr18:27,424,328...27,432,814 		JBrowse link
G Klf2 Kruppel-like factor 2 decreases expression EXP coumarin results in decreased expression of KLF2 mRNA CTD PMID:18480146 NCBI chr16:19,223,087...19,225,037
Ensembl chr16:19,223,087...19,225,037 		JBrowse link
G Krt19 keratin 19 decreases expression EXP coumarin results in decreased expression of KRT19 mRNA CTD PMID:18480146 NCBI chr10:88,055,843...88,060,560
Ensembl chr10:88,055,841...88,060,561 		JBrowse link
G Kynu kynureninase decreases expression EXP coumarin results in decreased expression of KYNU mRNA CTD PMID:18480146 NCBI chr 3:28,416,926...28,566,939
Ensembl chr 3:28,416,954...28,566,928 		JBrowse link
G Lad1 ladinin 1 increases expression EXP coumarin results in increased expression of LAD1 mRNA CTD PMID:18480146 NCBI chr13:52,645,257...52,659,619
Ensembl chr13:52,645,257...52,659,619 		JBrowse link
G Lmf2 lipase maturation factor 2 increases expression EXP coumarin results in increased expression of LMF2 mRNA CTD PMID:18480146 NCBI chr 7:130,322,018...130,326,470
Ensembl chr 7:130,322,020...130,326,470 		JBrowse link
G Lrp3 LDL receptor related protein 3 affects expression EXP coumarin affects the expression of LRP3 mRNA CTD PMID:16963487 NCBI chr 1:91,447,308...91,462,603
Ensembl chr 1:91,448,361...91,462,603 		JBrowse link
G Mat1a methionine adenosyltransferase 1A affects expression EXP coumarin affects the expression of MAT1A mRNA CTD PMID:16963487 NCBI chr16:18,690,649...18,709,135
Ensembl chr16:18,690,246...18,709,133 		JBrowse link
G Mbl2 mannose binding lectin 2 decreases expression EXP coumarin results in decreased expression of MBL2 mRNA CTD PMID:18480146 NCBI chr 1:248,435,069...248,442,669
Ensembl chr 1:248,723,397...248,729,962 		JBrowse link
G Mcm2 minichromosome maintenance complex component 2 increases expression EXP coumarin results in increased expression of MCM2 mRNA CTD PMID:18480146 NCBI chr 4:120,825,699...120,840,221
Ensembl chr 4:120,825,699...120,840,111 		JBrowse link
G Mcm3 minichromosome maintenance complex component 3 increases expression EXP coumarin results in increased expression of MCM3 mRNA CTD PMID:18480146 NCBI chr 9:26,914,057...26,932,201
Ensembl chr 9:26,914,057...26,932,201 		JBrowse link
G Mcm4 minichromosome maintenance complex component 4 increases expression EXP coumarin results in increased expression of MCM4 mRNA CTD PMID:18480146 NCBI chr11:89,511,191...89,524,892
Ensembl chr11:89,511,191...89,524,892 		JBrowse link
G Mcm5 minichromosome maintenance complex component 5 increases expression EXP coumarin results in increased expression of MCM5 mRNA CTD PMID:18480146 NCBI chr19:14,523,482...14,561,281
Ensembl chr19:14,523,554...14,561,278 		JBrowse link
G Mdm2 MDM2 proto-oncogene decreases expression ISO coumarin analog results in decreased expression of MDM2 mRNA CTD PMID:32578917 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328 		JBrowse link
G Mgp matrix Gla protein decreases expression ISO coumarin results in decreased expression of MGP mRNA CTD PMID:19350115 NCBI chr 4:170,856,783...170,860,105
Ensembl chr 4:170,856,751...170,860,225 		JBrowse link
G Mgst2 microsomal glutathione S-transferase 2 increases expression EXP coumarin results in increased expression of MGST2 mRNA CTD PMID:18480146 NCBI chr 2:140,708,396...140,727,381
Ensembl chr 2:140,708,397...140,727,281 		JBrowse link
G Mgst3 microsomal glutathione S-transferase 3 decreases expression EXP coumarin results in decreased expression of MGST3 mRNA CTD PMID:18480146 NCBI chr13:85,601,499...85,622,392
Ensembl chr13:85,601,499...85,622,314 		JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression ISO coumarin analog results in decreased expression of MMP2 mRNA CTD PMID:32578917 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611 		JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression
multiple interactions		 ISO coumarin analog results in decreased expression of MMP9 mRNA
coumarin analog results in decreased expression of and results in decreased activity of MMP9 protein		 CTD PMID:32578917 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520 		JBrowse link
G Mms22l MMS22-like, DNA repair protein increases expression EXP coumarin results in increased expression of MMS22L mRNA CTD PMID:18480146 NCBI chr 5:38,844,502...38,960,989
Ensembl chr 5:38,844,488...38,961,035 		JBrowse link
G Msmo1 methylsterol monooxygenase 1 affects expression EXP coumarin affects the expression of MSMO1 mRNA CTD PMID:16963487 NCBI chr16:26,859,441...26,875,880
Ensembl chr16:26,859,397...26,875,973 		JBrowse link
G Mt1 metallothionein 1 increases expression EXP coumarin results in increased expression of MT1A mRNA CTD PMID:18480146 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724 		JBrowse link
G Mt2A metallothionein 2A increases expression EXP coumarin results in increased expression of MT2A mRNA CTD PMID:18480146 NCBI chr19:11,307,966...11,308,740
Ensembl chr19:11,307,967...11,308,740 		JBrowse link
G Nectin2 nectin cell adhesion molecule 2 decreases expression EXP coumarin results in decreased expression of NECTIN2 mRNA CTD PMID:18480146 NCBI chr 1:80,631,449...80,666,617
Ensembl chr 1:80,631,450...80,666,585 		JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 affects activity
increases activity		 ISO coumarin affects the activity of NFE2L2 protein
coumarin results in increased activity of NFE2L2 protein		 CTD PMID:11309284, PMID:30114225, PMID:30203046 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996 		JBrowse link
G Nol3 nucleolar protein 3 increases expression EXP coumarin results in increased expression of NOL3 mRNA CTD PMID:18480146 NCBI chr19:37,232,567...37,236,668
Ensembl chr19:37,235,001...37,236,649 		JBrowse link
G Nol8 nucleolar protein 8 increases expression EXP coumarin results in increased expression of NOL8 mRNA CTD PMID:18480146 NCBI chr17:14,565,794...14,589,154
Ensembl chr17:14,565,794...14,589,154
Ensembl chr17:14,565,794...14,589,154 		JBrowse link
G Nop56 NOP56 ribonucleoprotein increases expression EXP coumarin results in increased expression of NOP56 mRNA CTD PMID:18480146 NCBI chr 3:122,803,726...122,808,564
Ensembl chr 3:122,803,772...122,808,558 		JBrowse link
G Nos2 nitric oxide synthase 2 increases expression EXP
ISO		 coumarin results in increased expression of NOS2 mRNA
coumarin analog results in increased expression of NOS2 mRNA; coumarin analog results in increased expression of NOS2 protein		 CTD PMID:15135310, PMID:32578917 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO
EXP		 coumarin results in increased expression of NQO1 mRNA; coumarin results in increased expression of NQO1 protein CTD PMID:11309284, PMID:17311802, PMID:18480146 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180 		JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 increases expression EXP coumarin results in increased expression of NR0B2 mRNA CTD PMID:18480146 NCBI chr 5:151,776,004...151,779,319
Ensembl chr 5:151,776,004...151,779,319 		JBrowse link
G Nr1d2 nuclear receptor subfamily 1, group D, member 2 increases expression EXP coumarin results in increased expression of NR1D2 mRNA CTD PMID:18480146 NCBI chr15:8,730,871...8,757,165
Ensembl chr15:8,730,871...8,757,165 		JBrowse link
G Nrep neuronal regeneration related protein decreases expression EXP coumarin results in decreased expression of NREP mRNA CTD PMID:18480146 NCBI chr18:26,183,753...26,212,796
Ensembl chr18:26,185,259...26,211,445 		JBrowse link
G Nrtn neurturin increases expression EXP coumarin results in increased expression of NRTN mRNA CTD PMID:18480146 NCBI chr 9:10,299,881...10,306,599
Ensembl chr 9:10,305,470...10,306,597 		JBrowse link
G Ntng1 netrin G1 decreases expression EXP coumarin results in decreased expression of NTNG1 mRNA CTD PMID:18480146 NCBI chr 2:212,695,464...213,073,046
Ensembl chr 2:212,696,624...212,852,870 		JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator increases expression EXP coumarin results in increased expression of NUPR1 mRNA CTD PMID:18480146 NCBI chr 1:194,767,484...194,769,519
Ensembl chr 1:194,767,474...194,769,524 		JBrowse link
G Oaf out at first homolog decreases expression EXP coumarin results in decreased expression of OAF mRNA CTD PMID:18480146 NCBI chr 8:47,511,718...47,529,689
Ensembl chr 8:47,511,719...47,529,689 		JBrowse link
G Oat ornithine aminotransferase decreases expression EXP coumarin results in decreased expression of OAT mRNA CTD PMID:18480146 NCBI chr 1:204,562,289...204,582,070
Ensembl chr 1:204,562,289...204,582,070 		JBrowse link
G Ogn osteoglycin decreases expression EXP coumarin results in decreased expression of OGN mRNA CTD PMID:18480146 NCBI chr17:14,607,442...14,628,274
Ensembl chr17:15,447,716...15,467,359
Ensembl chr17:15,447,716...15,467,359 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 decreases activity
decreases expression
increases cleavage
multiple interactions		 ISO coumarin results in decreased activity of PARP1 protein
coumarin analog results in decreased expression of PARP1 mRNA
coumarin analog results in increased cleavage of PARP1 protein
[coumarin results in decreased activity of PARP1 protein] inhibits the reaction [Tetrachlorodibenzodioxin results in decreased abundance of NAD]; [coumarin results in decreased activity of PARP1 protein] inhibits the reaction [Tetrachlorodibenzodioxin results in decreased abundance of NADP]		 CTD PMID:17669606, PMID:31199928, PMID:32578917 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716 		JBrowse link
G Pck2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) increases expression EXP coumarin results in increased expression of PCK2 mRNA CTD PMID:18480146 NCBI chr15:34,216,735...34,224,357
Ensembl chr15:34,216,833...34,224,193 		JBrowse link
G Pcna proliferating cell nuclear antigen increases expression ISO coumarin analog results in increased expression of PCNA mRNA CTD PMID:32578917 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570 		JBrowse link
G Pde4b phosphodiesterase 4B decreases expression EXP coumarin results in decreased expression of PDE4B mRNA CTD PMID:18480146 NCBI chr 5:121,759,236...122,136,814
Ensembl chr 5:121,952,977...122,136,814 		JBrowse link
G Pdia3 protein disulfide isomerase family A, member 3 increases expression EXP coumarin results in increased expression of PDIA3 mRNA CTD PMID:18480146 NCBI chr 3:113,376,983...113,400,707
Ensembl chr 3:113,376,983...113,400,707 		JBrowse link
G Pdia4 protein disulfide isomerase family A, member 4 increases expression EXP coumarin results in increased expression of PDIA4 mRNA CTD PMID:18480146 NCBI chr 4:77,470,636...77,489,535
Ensembl chr 4:77,470,636...77,489,535 		JBrowse link
G Pdk2 pyruvate dehydrogenase kinase 2 decreases expression EXP coumarin results in decreased expression of PDK2 mRNA CTD PMID:18480146 NCBI chr10:82,838,270...82,852,758
Ensembl chr10:82,839,153...82,852,660 		JBrowse link
G Pla2g12a phospholipase A2, group XIIA increases expression EXP coumarin results in increased expression of PLA2G12A mRNA CTD PMID:18480146 NCBI chr 2:235,311,664...235,327,972
Ensembl chr 2:235,311,719...235,327,972 		JBrowse link
G Pold1 DNA polymerase delta 1, catalytic subunit increases expression EXP coumarin results in increased expression of POLD1 mRNA CTD PMID:18480146 NCBI chr 1:100,538,066...100,554,105
Ensembl chr 1:100,537,900...100,554,488 		JBrowse link
G Pold2 DNA polymerase delta 2, accessory subunit increases expression EXP coumarin results in increased expression of POLD2 mRNA CTD PMID:18480146 NCBI chr14:86,111,416...86,117,578
Ensembl chr14:86,111,294...86,117,578 		JBrowse link
G Polr1e RNA polymerase I subunit E increases expression EXP coumarin results in increased expression of POLR1E mRNA CTD PMID:18480146 NCBI chr 5:60,572,573...60,588,097
Ensembl chr 5:60,572,577...60,588,240 		JBrowse link
G Ptgr1 prostaglandin reductase 1 increases expression EXP coumarin results in increased expression of PTGR1 mRNA CTD PMID:18480146 NCBI chr 5:76,110,746...76,129,361
Ensembl chr 5:76,110,738...76,129,441 		JBrowse link
G R3hdm1 R3H domain containing 1 increases expression EXP coumarin results in increased expression of R3HDM1 mRNA CTD PMID:18480146 NCBI chr13:44,812,567...44,950,762
Ensembl chr13:44,812,567...44,950,762 		JBrowse link
G R3hdm2 R3H domain containing 2 decreases expression EXP coumarin results in decreased expression of R3HDM2 mRNA CTD PMID:18480146 NCBI chr 7:70,677,226...70,805,255
Ensembl chr 7:70,697,050...70,805,221 		JBrowse link
G Rab3d RAB3D, member RAS oncogene family increases expression EXP coumarin results in increased expression of RAB3D mRNA CTD PMID:18480146 NCBI chr 8:22,920,238...22,929,368
Ensembl chr 8:22,918,699...22,929,294 		JBrowse link
G Rbm3 RNA binding motif protein 3 increases expression EXP coumarin results in increased expression of RBM3 mRNA CTD PMID:18480146 NCBI chr  X:15,098,880...15,102,344
Ensembl chr  X:15,098,904...15,102,340 		JBrowse link
G Rbp1 retinol binding protein 1 decreases expression EXP coumarin results in decreased expression of RBP1 mRNA CTD PMID:18480146 NCBI chr 8:106,449,321...106,470,842
Ensembl chr 8:106,449,321...106,470,842 		JBrowse link
G RGD1560171 similar to PRO0149 protein increases expression EXP coumarin results in increased expression of RGD1560171 mRNA CTD PMID:18480146 NCBI chr  X:143,681,714...143,683,171
Ensembl chr  X:143,682,099...143,682,917 		JBrowse link
G RGD1564865 similar to 20-alpha-hydroxysteroid dehydrogenase decreases expression EXP coumarin results in decreased expression of RGD1564865 mRNA CTD PMID:18480146 NCBI chr17:69,468,427...69,497,132
Ensembl chr17:69,468,427...69,497,132 		JBrowse link
G Rgn regucalcin decreases expression EXP coumarin results in decreased expression of RGN mRNA CTD PMID:18480146 NCBI chr  X:1,833,484...1,848,904
Ensembl chr  X:1,833,492...1,848,904 		JBrowse link
G Rgs8 regulator of G-protein signaling 8 decreases expression EXP coumarin results in decreased expression of RGS8 mRNA CTD PMID:18480146 NCBI chr13:71,086,654...71,141,820
Ensembl chr13:71,086,745...71,141,075 		JBrowse link
G Rprm reprimo, TP53 dependent G2 arrest mediator homolog decreases expression EXP coumarin results in decreased expression of RPRM mRNA CTD PMID:18480146 NCBI chr 3:39,595,301...39,596,718
Ensembl chr 3:39,595,301...39,596,718 		JBrowse link
G RT1-Ba RT1 class II, locus Ba increases expression EXP coumarin results in increased expression of RT1-BA mRNA CTD PMID:18480146 NCBI chr20:4,066,133...4,070,726
Ensembl chr20:4,066,132...4,070,721 		JBrowse link
G RT1-DMa RT1 class II, locus DMa increases expression EXP coumarin results in increased expression of HLA-DMA mRNA CTD PMID:18480146 NCBI chr20:3,935,512...3,938,915
Ensembl chr20:5,240,975...5,244,386 		JBrowse link
G RT1-EC2 RT1 class Ib, locus EC2 increases expression EXP coumarin results in increased expression of RT1-EC2 mRNA CTD PMID:18480146
G Saraf store-operated calcium entry-associated regulatory factor increases expression EXP coumarin results in increased expression of SARAF mRNA CTD PMID:18480146 NCBI chr16:61,735,189...61,753,438
Ensembl chr16:61,735,181...61,753,476 		JBrowse link
G Scd stearoyl-CoA desaturase decreases expression EXP coumarin results in decreased expression of SCD1 mRNA CTD PMID:18480146 NCBI chr 1:264,159,966...264,173,061
Ensembl chr 1:264,160,129...264,172,729 		JBrowse link
G Sdf2l1 stromal cell-derived factor 2-like 1 increases expression EXP coumarin results in increased expression of SDF2L1 mRNA CTD PMID:18480146 NCBI chr11:88,122,271...88,124,513
Ensembl chr11:88,122,271...88,124,513 		JBrowse link
G Sel1l SEL1L adaptor subunit of ERAD E3 ubiquitin ligase increases expression EXP coumarin results in increased expression of SEL1L mRNA CTD PMID:18480146 NCBI chr 6:115,572,683...115,616,904
Ensembl chr 6:115,572,649...115,616,859 		JBrowse link
G Sema6d semaphorin 6D increases expression EXP coumarin results in increased expression of SEMA6D mRNA CTD PMID:18480146 NCBI chr 3:116,899,906...116,958,059
Ensembl chr 3:116,899,878...116,958,050 		JBrowse link
G Slc17a1 solute carrier family 17 member 1 increases expression EXP coumarin results in increased expression of SLC17A1 mRNA CTD PMID:18480146 NCBI chr17:43,473,048...43,504,645 JBrowse link
G Slc17a3 solute carrier family 17 member 3 increases expression EXP coumarin results in increased expression of SLC17A3 mRNA CTD PMID:18480146 NCBI chr17:43,518,760...43,545,160
Ensembl chr17:43,518,655...43,543,185 		JBrowse link
G Slc1a2 solute carrier family 1 member 2 increases expression EXP coumarin results in increased expression of SLC1A2 mRNA CTD PMID:18480146 NCBI chr 3:92,518,679...92,665,731
Ensembl chr 3:92,640,752...92,665,644 		JBrowse link
G Slc27a2 solute carrier family 27 member 2 affects expression EXP coumarin affects the expression of SLC27A2 mRNA CTD PMID:16963487 NCBI chr 3:119,014,620...119,052,531
Ensembl chr 3:119,014,620...119,052,531 		JBrowse link
G Slc28a2 solute carrier family 28 member 2 decreases expression EXP coumarin results in decreased expression of SLC28A2 mRNA CTD PMID:18480146 NCBI chr 3:114,355,003...114,647,382
Ensembl chr 3:114,355,798...114,647,382 		JBrowse link
G Slc35e3 solute carrier family 35, member E3 increases expression EXP coumarin results in increased expression of SLC35E3 mRNA CTD PMID:18480146 NCBI chr 7:60,765,077...60,778,136
Ensembl chr 7:60,765,079...60,778,136 		JBrowse link
G Slc6a13 solute carrier family 6 member 13 decreases expression EXP coumarin results in decreased expression of SLC6A13 mRNA CTD PMID:18480146 NCBI chr 4:153,874,942...153,912,185
Ensembl chr 4:153,874,852...153,912,155 		JBrowse link
G Slc6a9 solute carrier family 6 member 9 increases expression EXP coumarin results in increased expression of SLC6A9 mRNA CTD PMID:18480146 NCBI chr 5:136,669,674...136,703,702
Ensembl chr 5:136,669,674...136,703,697 		JBrowse link
G Smpdl3b sphingomyelin phosphodiesterase, acid-like 3B increases expression EXP coumarin results in increased expression of SMPDL3B mRNA CTD PMID:18480146 NCBI chr 5:150,925,150...150,946,994
Ensembl chr 5:150,925,370...150,949,931 		JBrowse link
G Snai2 snail family transcriptional repressor 2 decreases expression ISO coumarin analog results in decreased expression of SNAI2 mRNA CTD PMID:32578917 NCBI chr11:90,404,421...90,406,730
Ensembl chr11:90,403,333...90,406,797 		JBrowse link
G Srxn1 sulfiredoxin 1 increases expression EXP coumarin results in increased expression of SRXN1 mRNA CTD PMID:18480146 NCBI chr 3:147,608,850...147,614,410
Ensembl chr 3:147,609,095...147,632,801 		JBrowse link
G Stat5b signal transducer and activator of transcription 5B increases activity ISO coumarin results in increased activity of STAT5B protein CTD PMID:30114225 NCBI chr10:88,686,207...88,712,313
Ensembl chr10:88,686,207...88,754,829 		JBrowse link
G Sult1b1 sulfotransferase family 1B member 1 affects expression EXP coumarin affects the expression of SULT1B1 mRNA CTD PMID:16963487 NCBI chr14:22,142,412...22,155,246
Ensembl chr14:22,142,364...22,155,231 		JBrowse link
G Sult1c3 sulfotransferase family 1C member 3 decreases expression EXP coumarin results in decreased expression of SULT1C1 mRNA CTD PMID:18480146 NCBI chr 9:4,931,038...4,978,847
Ensembl chr 9:4,930,818...4,978,892 		JBrowse link
G Sult1e1 sulfotransferase family 1E member 1 decreases expression EXP coumarin results in decreased expression of SULT1E1 mRNA CTD PMID:18480146 NCBI chr14:22,070,861...22,089,264
Ensembl chr14:22,072,024...22,089,248 		JBrowse link
G Sycp3 synaptonemal complex protein 3 decreases expression EXP coumarin results in decreased expression of SYCP3 mRNA CTD PMID:18480146 NCBI chr 7:29,029,887...29,044,344
Ensembl chr 7:29,029,263...29,044,251 		JBrowse link
G Syne4 spectrin repeat containing nuclear envelope family member 4 increases expression EXP coumarin results in increased expression of SYNE4 mRNA CTD PMID:18480146 NCBI chr 1:88,772,729...88,777,044
Ensembl chr 1:88,772,904...88,776,999
Ensembl chr 1:88,772,904...88,776,999 		JBrowse link
G Tfrc transferrin receptor increases expression EXP coumarin results in increased expression of TFRC mRNA CTD PMID:18480146 NCBI chr11:71,397,423...71,419,263
Ensembl chr11:71,397,383...71,419,223 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression ISO coumarin analog results in increased expression of TGFB1 mRNA CTD PMID:32578917 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199 		JBrowse link
G Thra thyroid hormone receptor alpha increases expression EXP coumarin results in increased expression of THRA mRNA CTD PMID:18480146 NCBI chr10:86,657,285...86,684,935
Ensembl chr10:86,657,285...86,684,933 		JBrowse link
G Thrsp thyroid hormone responsive affects expression
decreases expression		 EXP coumarin affects the expression of THRSP mRNA
coumarin results in decreased expression of THRSP mRNA		 CTD PMID:16963487, PMID:18480146 NCBI chr 1:162,381,251...162,385,575
Ensembl chr 1:162,381,253...162,385,575 		JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 increases expression ISO coumarin analog results in increased expression of TIMP2 mRNA CTD PMID:32578917 NCBI chr10:107,338,465...107,386,072
Ensembl chr10:107,338,465...107,386,072 		JBrowse link
G Timp4 TIMP metallopeptidase inhibitor 4 increases expression ISO coumarin analog results in increased expression of TIMP4 mRNA CTD PMID:32578917 NCBI chr 4:147,156,948...147,163,467
Ensembl chr 4:147,156,948...147,163,467 		JBrowse link
G Tmed3 transmembrane p24 trafficking protein 3 increases expression EXP coumarin results in increased expression of TMED3 mRNA CTD PMID:18480146 NCBI chr 8:97,075,194...97,083,107
Ensembl chr 8:97,075,160...97,083,120 		JBrowse link
G Tnf tumor necrosis factor increases expression EXP
ISO		 coumarin results in increased expression of TNF mRNA
coumarin analog results in increased expression of TNF protein		 CTD PMID:15135310, PMID:32578917 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Tnfrsf9 TNF receptor superfamily member 9 decreases expression EXP coumarin results in decreased expression of TNFRSF9 mRNA CTD PMID:18480146 NCBI chr 5:168,009,245...168,035,813
Ensembl chr 5:168,009,393...168,035,810 		JBrowse link
G Tp53 tumor protein p53 increases expression ISO coumarin analog results in increased expression of TP53 mRNA; coumarin analog results in increased expression of TP53 protein CTD PMID:32578917 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449 		JBrowse link
G Tradd TNFRSF1A-associated via death domain increases expression ISO coumarin analog results in increased expression of TRADD mRNA CTD PMID:32578917 NCBI chr19:37,214,461...37,221,099
Ensembl chr19:37,214,471...37,216,572 		JBrowse link
G Trpc2 transient receptor potential cation channel subfamily C member 2 increases expression EXP coumarin results in increased expression of TRPC2 mRNA CTD PMID:18480146 NCBI chr 1:167,180,103...167,192,456
Ensembl chr 1:167,169,442...167,192,801 		JBrowse link
G Tsc22d1 TSC22 domain family, member 1 decreases expression EXP coumarin results in decreased expression of TSC22D1 mRNA CTD PMID:18480146 NCBI chr15:58,554,358...58,658,156
Ensembl chr15:58,554,374...58,658,153 		JBrowse link
G Tst thiosulfate sulfurtransferase affects expression EXP coumarin affects the expression of TST mRNA CTD PMID:16963487 NCBI chr 7:119,616,323...119,623,072
Ensembl chr 7:119,616,324...119,623,072 		JBrowse link
G Ttc39a tetratricopeptide repeat domain 39A increases expression EXP coumarin results in increased expression of TTC39A mRNA CTD PMID:18480146 NCBI chr 5:129,024,505...129,083,226
Ensembl chr 5:129,043,675...129,082,442
Ensembl chr 5:129,043,675...129,082,442 		JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression EXP coumarin results in increased expression of TXNRD1 mRNA CTD PMID:18480146 NCBI chr 7:26,946,124...26,984,400
Ensembl chr 7:26,946,125...26,984,400 		JBrowse link
G Ugdh UDP-glucose 6-dehydrogenase increases expression EXP coumarin results in increased expression of UGDH mRNA CTD PMID:18480146 NCBI chr14:44,479,614...44,502,845
Ensembl chr14:44,479,614...44,502,845 		JBrowse link
G Ugt2b UDP glycosyltransferase 2 family, polypeptide B decreases expression EXP coumarin results in decreased expression of UGT2B mRNA CTD PMID:18480146 Ensembl chr14:22,375,955...22,534,720 JBrowse link
G Ust5r integral membrane transport protein UST5r decreases expression EXP coumarin results in decreased expression of UST5R mRNA CTD PMID:18480146 NCBI chr 1:224,457,895...224,533,994
Ensembl chr 1:224,457,900...224,533,219 		JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO coumarin analog results in increased expression of VEGFA mRNA CTD PMID:32578917 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681 		JBrowse link
G Vim vimentin decreases expression ISO coumarin analog results in decreased expression of VIM protein CTD PMID:32578917 NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212 		JBrowse link
G Vkorc1 vitamin K epoxide reductase complex, subunit 1 decreases response to substance
increases response to substance		 ISO VKORC1 gene mutant form results in decreased susceptibility to coumarin
VKORC1 gene mutant form results in increased susceptibility to coumarin; VKORC1 promoter SNP results in increased susceptibility to coumarin		 CTD PMID:17849045, PMID:18278162 NCBI chr 1:199,338,785...199,341,306
Ensembl chr 1:199,337,138...199,341,302 		JBrowse link
G Wee1 WEE1 G2 checkpoint kinase increases expression EXP coumarin results in increased expression of WEE1 mRNA CTD PMID:18480146 NCBI chr 1:174,765,228...174,790,882
Ensembl chr 1:174,767,960...174,786,361 		JBrowse link
G Yrdc yrdC N(6)-threonylcarbamoyltransferase domain containing increases expression EXP coumarin results in increased expression of YRDC mRNA CTD PMID:18480146 NCBI chr 5:142,845,265...142,850,110
Ensembl chr 5:142,845,114...142,850,111 		JBrowse link
G Zeb1 zinc finger E-box binding homeobox 1 decreases expression ISO coumarin analog results in decreased expression of ZEB1 mRNA CTD PMID:32578917 NCBI chr17:54,656,627...54,714,920
Ensembl chr17:54,658,463...54,714,914 		JBrowse link
G Zfp444 zinc finger protein 444 increases expression EXP coumarin results in increased expression of ZFP444 mRNA CTD PMID:18480146 NCBI chr 1:71,380,856...71,400,781
Ensembl chr 1:71,379,559...71,400,388 		JBrowse link
G Zfp593 zinc finger protein 593 increases expression EXP coumarin results in increased expression of ZNF593 mRNA CTD PMID:18480146 NCBI chr 5:152,462,522...152,464,850
Ensembl chr 5:152,462,522...152,464,850 		JBrowse link
G Zwint ZW10 interacting kinetochore protein increases expression EXP coumarin results in increased expression of ZWINT mRNA CTD PMID:18480146 NCBI chr20:17,075,781...17,091,715
Ensembl chr20:17,075,771...17,091,766 		JBrowse link
coumarin 460 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akap9 A-kinase anchoring protein 9 increases expression ISO 4-methyl-7-diethylaminocoumarin results in increased expression of AKAP9 mRNA CTD PMID:19502547 NCBI chr 4:27,195,346...27,331,582
Ensembl chr 4:27,195,346...27,331,582 		JBrowse link
G Ankrd37 ankyrin repeat domain 37 increases expression ISO 4-methyl-7-diethylaminocoumarin results in increased expression of ANKRD37 mRNA CTD PMID:19502547 NCBI chr16:49,463,016...49,465,905
Ensembl chr16:49,462,889...49,465,888 		JBrowse link
G Ar androgen receptor multiple interactions
affects localization		 ISO 4-methyl-7-diethylaminocoumarin binds to and results in increased activity of AR protein
4-methyl-7-diethylaminocoumarin affects the localization of AR protein		 CTD PMID:28478275 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases activity ISO 4-methyl-7-diethylaminocoumarin results in increased activity of HIF1A protein CTD PMID:19502547 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052 		JBrowse link
G Pfkm phosphofructokinase, muscle increases expression ISO 4-methyl-7-diethylaminocoumarin results in increased expression of PFKM mRNA CTD PMID:19502547 NCBI chr 7:139,702,066...139,722,132
Ensembl chr 7:139,685,573...139,722,132 		JBrowse link
G Psph phosphoserine phosphatase increases expression ISO 4-methyl-7-diethylaminocoumarin results in increased expression of PSPH mRNA CTD PMID:19502547 NCBI chr12:30,514,128...30,526,551
Ensembl chr12:30,514,112...30,526,557 		JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO 4-methyl-7-diethylaminocoumarin results in increased expression of VEGFA protein CTD PMID:19502547 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681 		JBrowse link
coumarins term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aifm1 apoptosis inducing factor, mitochondria associated 1 affects localization ISO Coumarins affects the localization of AIFM1 protein CTD PMID:19705353 NCBI chr  X:135,304,063...135,343,062
Ensembl chr  X:135,304,066...135,343,087 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Coumarins analog results in decreased expression of BCL2 protein CTD PMID:25231984 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO Coumarins analog results in decreased expression of BIRC5 protein CTD PMID:25231984 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413 		JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO Coumarins analog results in decreased expression of CCND1 protein CTD PMID:25231984 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions ISO [CYP2D6 protein results in increased metabolism of 7-methoxy-4-(aminomethyl)coumarin] which results in increased chemical synthesis of Coumarins; Quinidine inhibits the reaction [[CYP2D6 protein results in increased metabolism of 7-methoxy-4-(aminomethyl)coumarin] which results in increased chemical synthesis of Coumarins] CTD PMID:23850985 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436 		JBrowse link
G Esr1 estrogen receptor 1 decreases expression ISO Coumarins analog results in decreased expression of ESR1 protein CTD PMID:17275315 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796 		JBrowse link
G Ifng interferon gamma multiple interactions ISO Coumarins inhibits the reaction [Dextran Sulfate results in increased expression of IFNG protein] CTD PMID:25231984 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419 		JBrowse link
G Il10 interleukin 10 multiple interactions ISO Coumarins inhibits the reaction [Dextran Sulfate results in decreased expression of IL10 protein] CTD PMID:25231984 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Coumarins inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein] CTD PMID:25231984 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO Coumarins inhibits the reaction [Dextran Sulfate results in increased expression of IL6 protein] CTD PMID:25231984 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression ISO Coumarins analog results in decreased expression of MCL1 protein CTD PMID:25231984 NCBI chr 2:197,786,212...197,788,992 JBrowse link
G Mpo myeloperoxidase multiple interactions ISO Coumarins inhibits the reaction [Dextran Sulfate results in increased activity of MPO protein] CTD PMID:25231984 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO Coumarins analog results in increased cleavage of PARP1 protein CTD PMID:25231984 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716 		JBrowse link
G Pon1 paraoxonase 1 increases hydrolysis ISO PON1 protein results in increased hydrolysis of Coumarins CTD PMID:20353174 NCBI chr 4:30,249,749...30,276,297
Ensembl chr 4:30,249,742...30,276,372 		JBrowse link
G Pon2 paraoxonase 2 increases hydrolysis ISO PON2 protein results in increased hydrolysis of Coumarins CTD PMID:20353174 NCBI chr 4:30,344,705...30,380,119
Ensembl chr 4:30,344,709...30,380,119 		JBrowse link
G Pon3 paraoxonase 3 increases hydrolysis ISO PON3 protein results in increased hydrolysis of Coumarins analog CTD PMID:16099434, PMID:16139510 NCBI chr 4:30,311,981...30,338,679
Ensembl chr 4:30,311,982...30,338,679 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases phosphorylation ISO Coumarins analog results in decreased phosphorylation of RELA protein CTD PMID:25231984 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
affects binding		 ISO Coumarins analog inhibits the reaction [[Thioglycolates co-treated with Lipopolysaccharides] results in increased expression of TNF protein]; Coumarins inhibits the reaction [Dextran Sulfate results in increased expression of TNF protein]
Coumarins analog binds to TNF protein		 CTD PMID:25231984 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 multiple interactions ISO
EXP		 Coumarins analog promotes the reaction [UGT1A1 protein results in increased glucuronidation of Bilirubin] CTD PMID:17599282 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822 		JBrowse link
G Vkorc1 vitamin K epoxide reductase complex, subunit 1 affects activity ISO Coumarins affects the activity of VKORC1 protein CTD PMID:18278162 NCBI chr 1:199,338,785...199,341,306
Ensembl chr 1:199,337,138...199,341,302 		JBrowse link
Coumatetralyl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Vkorc1 vitamin K epoxide reductase complex, subunit 1 decreases response to substance
multiple interactions
decreases activity		 EXP
ISO		 VKORC1 protein polymorphism results in decreased susceptibility to coumatetralyl
coumatetralyl inhibits the reaction [VKORC1 protein results in increased reduction of Vitamin K 1]
coumatetralyl results in decreased activity of VKORC1 protein		 CTD PMID:27117082, PMID:29581108 NCBI chr 1:199,338,785...199,341,306
Ensembl chr 1:199,337,138...199,341,302 		JBrowse link
G Vkorc1l1 vitamin K epoxide reductase complex, subunit 1-like 1 multiple interactions
decreases activity		 ISO coumatetralyl inhibits the reaction [VKORC1L1 protein results in increased reduction of Vitamin K 1]
coumatetralyl results in decreased activity of VKORC1L1 protein		 CTD PMID:29581108 NCBI chr12:30,218,825...30,268,990
Ensembl chr12:30,222,701...30,268,990 		JBrowse link
Decursin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity ISO decursin results in decreased activity of ACHE protein CTD PMID:12482674 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753 		JBrowse link
G Ar androgen receptor increases degradation
multiple interactions		 ISO decursin results in increased degradation of AR protein
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [decursin results in increased degradation of AR protein]; decursin results in decreased localization of and results in decreased expression of AR protein		 CTD PMID:17723170 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026 		JBrowse link
G Cat catalase multiple interactions ISO [decursin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CAT protein CTD PMID:31351099 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO decursin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CCL2 protein] CTD PMID:31351099 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870 		JBrowse link
G Ccl4 C-C motif chemokine ligand 4 multiple interactions ISO decursin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CCL4 protein] CTD PMID:31351099 NCBI chr10:70,870,926...70,886,357
Ensembl chr10:70,884,531...70,886,355 		JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions ISO decursin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CHUK protein] CTD PMID:31351099 NCBI chr 1:263,848,829...263,884,354
Ensembl chr 1:263,848,884...263,885,169 		JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions ISO decursin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CXCL2 protein] CTD PMID:31351099 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO decursin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ICAM1 protein] CTD PMID:31351099 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059 		JBrowse link
G Ifng interferon gamma multiple interactions ISO decursin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IFNG protein] CTD PMID:31351099 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419 		JBrowse link
G Ikbkg inhibitor of nuclear factor kappa B kinase regulatory subunit gamma multiple interactions ISO decursin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IKBKG protein] CTD PMID:31351099 NCBI chr  X:156,254,187...156,280,046
Ensembl chr  X:156,257,173...156,270,748 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO decursin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL1B protein] CTD PMID:31351099 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO decursin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL6 protein] CTD PMID:31351099 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO decursin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein] CTD PMID:31351099 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO decursin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK3 protein] CTD PMID:31351099 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO decursin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of NFKBIA protein] CTD PMID:31351099 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457 		JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions ISO decursin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of NOS1 protein] CTD PMID:31351099 NCBI chr12:44,214,949...44,405,530
Ensembl chr12:44,213,943...44,520,341 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO decursin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of NOS2 protein] CTD PMID:31351099 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190 		JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO decursin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of NOS3 protein] CTD PMID:31351099 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO decursin results in increased cleavage of PARP1 protein CTD PMID:17723170 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO decursin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein] CTD PMID:31351099 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO decursin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of RELA protein] CTD PMID:31351099 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO [decursin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of SOD1 protein CTD PMID:31351099 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO [decursin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of SOD2 protein CTD PMID:31351099 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO decursin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TNF protein] CTD PMID:31351099 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
dicoumarol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c1 aldo-keto reductase family 1, member C1 decreases activity EXP Dicumarol results in decreased activity of AKR1C6 protein CTD PMID:16788056 NCBI chr17:69,441,253...69,460,334
Ensembl chr17:69,441,223...69,460,321 		JBrowse link
G Alb albumin affects binding ISO Dicumarol binds to ALB protein CTD PMID:62049 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863 		JBrowse link
G Atm ATM serine/threonine kinase multiple interactions ISO Dicumarol inhibits the reaction [2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone analog results in increased expression of ATM protein modified form] CTD PMID:26630137 NCBI chr 8:58,015,938...58,119,973
Ensembl chr 8:58,015,940...58,120,045 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP
ISO		 [aminochrome 1 co-treated with Dicumarol] results in increased activity of CASP3 protein; Dicumarol promotes the reaction [Doxorubicin results in increased activity of CASP3 protein]; Progesterone inhibits the reaction [Dicumarol promotes the reaction [Doxorubicin results in increased activity of CASP3 protein]]
Dicumarol inhibits the reaction [2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone analog results in decreased expression of CASP3 protein]		 CTD PMID:21427056, PMID:21947872, PMID:26630137 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Cat catalase decreases response to substance
multiple interactions		 ISO
EXP		 CAT protein results in decreased susceptibility to Dicumarol
[Dopamine co-treated with Dicumarol] results in increased expression of CAT mRNA		 CTD PMID:11299314, PMID:17040906 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058 		JBrowse link
G Cd86 CD86 molecule multiple interactions ISO [Dicumarol results in decreased activity of NQO1 protein] inhibits the reaction [Eugenol results in increased expression of CD86 protein] CTD PMID:21742781 NCBI chr11:67,060,305...67,117,990
Ensembl chr11:67,082,193...67,118,795 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO Dicumarol inhibits the reaction [diaziquone results in increased expression of CDKN1A mRNA]; Dicumarol inhibits the reaction [RB1CC1 protein results in increased expression of CDKN1A protein] CTD PMID:9343371, PMID:16061648 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864 		JBrowse link
G Cycs cytochrome c, somatic multiple interactions EXP [aminochrome 1 co-treated with Dicumarol] affects the localization of CYCS protein CTD PMID:21427056 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions EXP Dicumarol promotes the reaction [CYP2E1 protein results in increased reduction of tirapazamine] CTD PMID:7710944 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542 		JBrowse link
G Drd5 dopamine receptor D5 increases expression EXP Dicumarol results in increased expression of DRD5 mRNA CTD PMID:18522901 NCBI chr14:77,220,579...77,222,006
Ensembl chr14:77,220,579...77,222,006 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions ISO Dicumarol inhibits the reaction [1-nitropyrene results in increased expression of HSPA5 protein] CTD PMID:19460413 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762 		JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions ISO Dicumarol inhibits the reaction [IGF1 protein results in increased phosphorylation of JUN protein] CTD PMID:11278392 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Dicumarol inhibits the reaction [IL1B protein results in increased expression of TP53 protein] CTD PMID:17959154 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Dicumarol inhibits the reaction [IGF1 protein results in increased phosphorylation of JUN protein]; Dicumarol inhibits the reaction [TNF protein results in increased phosphorylation of JUN protein] CTD PMID:11278392, PMID:17669387 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Dicumarol inhibits the reaction [TNF protein results in increased phosphorylation of MAPK1 protein] CTD PMID:17669387 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk10 mitogen activated protein kinase 10 multiple interactions
decreases activity		 ISO Dicumarol inhibits the reaction [Anisomycin results in increased activity of MAPK10 protein]; Dicumarol inhibits the reaction [Sorbitol results in increased activity of MAPK10 protein]; Dicumarol inhibits the reaction [TRAF2 protein results in increased activity of MAPK10 protein]; NQO1 protein inhibits the reaction [Dicumarol results in decreased activity of MAPK10 protein] CTD PMID:10531305 NCBI chr14:8,079,955...8,371,508
Ensembl chr14:8,080,275...8,368,254 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Dicumarol inhibits the reaction [TNF protein results in increased phosphorylation of MAPK3 protein] CTD PMID:17669387 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO Dicumarol inhibits the reaction [Adenosine Diphosphate results in increased phosphorylation of MAPK8 protein]; Dicumarol inhibits the reaction [Arsenic Trioxide results in increased activity of MAPK8 protein] CTD PMID:14701702, PMID:24466103 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions ISO Dicumarol inhibits the reaction [Adenosine Diphosphate results in increased phosphorylation of MAPK9 protein] CTD PMID:24466103 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO Dicumarol inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of MMP9 protein]; Dicumarol inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]; hydroquinone inhibits the reaction [Dicumarol inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of MMP9 protein]] CTD PMID:17669387 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520 		JBrowse link
G Mt1 metallothionein 1 multiple interactions ISO Dicumarol inhibits the reaction [Cadmium Chloride results in increased expression of MT1 mRNA]; Dicumarol inhibits the reaction [zinc chloride results in increased expression of MT1 mRNA]; Dicumarol inhibits the reaction [Zinc Sulfate results in increased expression of MT1 mRNA] CTD PMID:11551972, PMID:15142038 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO Dicumarol inhibits the reaction [Lipopolysaccharides results in increased activity of NFKB1 protein]; Dicumarol inhibits the reaction [TNF protein results in increased activity of NFKB1 protein] CTD PMID:10531305 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions
decreases activity
decreases expression
affects response to substance		 ISO
EXP		 [Dicumarol results in decreased activity of NQO1 protein] inhibits the reaction [Eugenol results in increased expression of CD86 protein]; [Dicumarol results in decreased activity of NQO1 protein] which results in decreased susceptibility to Mitomycin; [Dicumarol results in decreased activity of NQO1 protein] which results in decreased susceptibility to Streptonigrin; Dicumarol inhibits the reaction [[arsenite results in increased expression of NQO1 protein] which results in increased susceptibility to Mitomycin]; Dicumarol inhibits the reaction [NQO1 protein results in decreased susceptibility to arsenite]; Dicumarol inhibits the reaction [NQO1 protein results in increased metabolism of Mitomycin]; Dicumarol inhibits the reaction [NQO1 protein results in increased reduction of 2,6-Dichloroindophenol]; Dicumarol inhibits the reaction [TP53 protein binds to NQO1 protein]; NQO1 protein inhibits the reaction [Dicumarol results in decreased activity of MAPK10 protein]
[Dicumarol results in decreased activity of NQO1 protein] which results in decreased activity of diaziquone; Dicumarol results in decreased activity of NQO1 protein
Dicumarol results in decreased expression of NQO1 protein
[Dicumarol results in decreased activity of NQO1 protein] which results in decreased reduction of Chromium; Dicumarol inhibits the reaction [Benzo(a)pyrene results in increased activity of NQO1 protein]; Dicumarol inhibits the reaction [NQO1 protein inhibits the reaction [Vitamin K 3 results in increased chemical synthesis of Hydrogen Peroxide]]; Dicumarol inhibits the reaction [Progesterone results in increased activity of NQO1 protein]; Dicumarol inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of NQO1 protein]
[Dicumarol results in decreased activity of NQO1 protein] which results in decreased abundance of aristolactam I; [Dicumarol results in decreased activity of NQO1 protein] which results in increased abundance of aristolochic acid I; [Dicumarol results in decreased activity of NQO1 protein] which results in increased abundance of aristolochic acid I metabolite
NQO1 protein affects the susceptibility to Dicumarol		 CTD PMID:1379126, PMID:1701346, PMID:2113030, PMID:8572925, PMID:10092053, PMID:10531305, PMID:11154737, PMID:14634213, PMID:15655414, PMID:15805261, PMID:16494910, PMID:17669387, PMID:17979524, PMID:19497421, PMID:21613233, PMID:21742781, PMID:21947872, PMID:27558805, PMID:29281794 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180 		JBrowse link
G Rb1 RB transcriptional corepressor 1 increases phosphorylation ISO Dicumarol results in increased phosphorylation of RB1 protein CTD PMID:15896341 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342 		JBrowse link
G Rb1cc1 RB1-inducible coiled-coil 1 multiple interactions ISO Dicumarol inhibits the reaction [RB1CC1 protein results in increased expression of CDKN1A protein]; Dicumarol inhibits the reaction [RB1CC1 protein results in increased expression of TP53 protein]; Dicumarol inhibits the reaction [RB1CC1 protein results in increased stability of TP53 protein] CTD PMID:16061648 NCBI chr 5:13,033,918...13,097,369
Ensembl chr 5:13,033,918...13,097,341 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Dicumarol inhibits the reaction [Lipopolysaccharides results in increased activity of RELA protein]; Dicumarol inhibits the reaction [TNF protein affects the localization of RELA protein]; Dicumarol inhibits the reaction [TNF protein results in increased activity of RELA protein] CTD PMID:10531305, PMID:17669387 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G Slc30a1 solute carrier family 30 member 1 multiple interactions ISO Dicumarol inhibits the reaction [Cadmium Chloride results in increased expression of SLC30A1 mRNA]; Dicumarol inhibits the reaction [Zinc Sulfate results in increased expression of SLC30A1 mRNA] CTD PMID:15142038 NCBI chr13:110,677,810...110,681,683
Ensembl chr13:110,677,810...110,681,683 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions EXP [Dopamine co-treated with Dicumarol co-treated with Copper Sulfate] results in decreased expression of SOD1 mRNA CTD PMID:11299314 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862 		JBrowse link
G Sod2 superoxide dismutase 2 decreases response to substance
multiple interactions		 ISO
EXP		 SOD2 protein results in decreased susceptibility to Dicumarol
[Dopamine co-treated with Dicumarol co-treated with Copper Sulfate] results in decreased expression of SOD2 mRNA		 CTD PMID:11299314, PMID:17040906 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Dicumarol inhibits the reaction [TNF protein affects the localization of RELA protein]; Dicumarol inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]; Dicumarol inhibits the reaction [TNF protein results in increased activity of RELA protein]; Dicumarol inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of MMP9 protein]; Dicumarol inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]; Dicumarol inhibits the reaction [TNF protein results in increased phosphorylation of JUN protein]; Dicumarol inhibits the reaction [TNF protein results in increased phosphorylation of MAPK1 protein]; Dicumarol inhibits the reaction [TNF protein results in increased phosphorylation of MAPK3 protein]; hydroquinone inhibits the reaction [Dicumarol inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of MMP9 protein]] CTD PMID:10531305, PMID:17669387 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Tp53 tumor protein p53 multiple interactions
decreases expression
increases degradation		 ISO Dicumarol inhibits the reaction [2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone analog results in increased expression of TP53 protein modified form]; Dicumarol inhibits the reaction [2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone analog results in increased expression of TP53 protein]; Dicumarol inhibits the reaction [IL1B protein results in increased expression of TP53 protein]; Dicumarol inhibits the reaction [RB1CC1 protein results in increased expression of TP53 protein]; Dicumarol inhibits the reaction [RB1CC1 protein results in increased stability of TP53 protein]; Dicumarol inhibits the reaction [TP53 protein binds to NQO1 protein]
Dicumarol results in decreased expression of TP53 protein
Dicumarol results in increased degradation of TP53 protein		 CTD PMID:14634213, PMID:16061648, PMID:17959154, PMID:22692362, PMID:26630137 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449 		JBrowse link
G Traf2 Tnf receptor-associated factor 2 multiple interactions ISO Dicumarol inhibits the reaction [TRAF2 protein results in increased activity of MAPK10 protein] CTD PMID:10531305 NCBI chr 3:2,746,061...2,770,690
Ensembl chr 3:2,746,075...2,770,620 		JBrowse link
G Vkorc1 vitamin K epoxide reductase complex, subunit 1 decreases activity
multiple interactions		 ISO Dicumarol results in decreased activity of VKORC1 protein
Dicumarol inhibits the reaction [VKORC1 protein results in increased reduction of Vitamin K 1]		 CTD PMID:29581108 NCBI chr 1:199,338,785...199,341,306
Ensembl chr 1:199,337,138...199,341,302 		JBrowse link
G Vkorc1l1 vitamin K epoxide reductase complex, subunit 1-like 1 multiple interactions
decreases activity		 ISO Dicumarol inhibits the reaction [VKORC1L1 protein results in increased reduction of Vitamin K 1]
Dicumarol results in decreased activity of VKORC1L1 protein		 CTD PMID:29581108 NCBI chr12:30,218,825...30,268,990
Ensembl chr12:30,222,701...30,268,990 		JBrowse link
esculetin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agtr1a angiotensin II receptor, type 1a multiple interactions EXP esculetin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of AGTR1A mRNA]; esculetin inhibits the reaction [Dietary Fats results in increased expression of AGTR1A mRNA] CTD PMID:28946194 NCBI chr17:35,907,102...35,958,136
Ensembl chr17:35,907,108...35,958,077 		JBrowse link
G Agtr2 angiotensin II receptor, type 2 multiple interactions EXP esculetin inhibits the reaction [Dietary Fats results in increased expression of AGTR2 mRNA]; esculetin promotes the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of AGTR2 mRNA] CTD PMID:28946194 NCBI chr  X:119,389,480...119,393,845
Ensembl chr  X:119,390,013...119,393,842 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation ISO esculetin results in increased phosphorylation of AKT1 protein CTD PMID:24995577 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258 		JBrowse link
G Alox15 arachidonate 15-lipoxygenase decreases expression ISO esculetin results in decreased expression of ALOX15 protein CTD PMID:30171828 NCBI chr10:56,953,692...56,962,145
Ensembl chr10:56,953,691...56,962,161 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases expression ISO esculetin results in increased expression of BAK1 protein CTD PMID:26388407 NCBI chr20:5,609,620...5,618,899
Ensembl chr20:5,609,625...5,618,260 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
affects expression
affects localization		 ISO [esculetin co-treated with Paclitaxel] results in increased expression of BAX protein
esculetin results in increased expression of BAX protein
esculetin affects the expression of BAX protein
esculetin affects the localization of BAX protein		 CTD PMID:16051289, PMID:19786087, PMID:24995577, PMID:26388407, PMID:31313495 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Bcl2 BCL2, apoptosis regulator affects expression
decreases expression		 ISO esculetin affects the expression of BCL2 protein
esculetin results in decreased expression of BCL2 protein		 CTD PMID:24995577, PMID:26388407, PMID:31313495 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions
decreases expression		 ISO [esculetin co-treated with Paclitaxel] results in decreased expression of BCL2L1 protein
esculetin results in decreased expression of BCL2L1 protein		 CTD PMID:16051289, PMID:26388407 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810 		JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions ISO [arsenic trioxide co-treated with esculetin] results in increased cleavage of BID protein CTD PMID:19428345 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203 		JBrowse link
G Bmp6 bone morphogenetic protein 6 multiple interactions EXP esculetin inhibits the reaction [Streptozocin results in decreased expression of BMP6 mRNA] CTD PMID:21450970 NCBI chr17:26,955,142...27,112,820
Ensembl chr17:26,955,142...27,112,820 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
increases activity		 ISO [esculetin co-treated with Paclitaxel] results in increased cleavage of and results in increased activity of CASP3 protein
esculetin results in increased cleavage of CASP3 protein
esculetin results in increased activity of CASP3 protein		 CTD PMID:16051289, PMID:24995577, PMID:26388407, PMID:31313495 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Casp7 caspase 7 increases cleavage ISO esculetin results in increased cleavage of CASP7 protein CTD PMID:31313495 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774 		JBrowse link
G Casp8 caspase 8 multiple interactions ISO [esculetin co-treated with Paclitaxel] results in increased cleavage of and results in increased activity of CASP8 protein CTD PMID:16051289 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106 		JBrowse link
G Casp9 caspase 9 increases activity
increases cleavage		 ISO esculetin results in increased activity of CASP9 protein
esculetin results in increased cleavage of CASP9 protein		 CTD PMID:24995577, PMID:26388407, PMID:31313495 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO esculetin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of CCL2 protein] CTD PMID:27769711 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870 		JBrowse link
G Ccnd1 cyclin D1 decreases expression EXP
ISO		 esculetin results in decreased expression of CCND1 protein CTD PMID:21600278, PMID:31313495 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325 		JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression
multiple interactions		 EXP esculetin results in decreased expression of CDK2 protein
esculetin promotes the reaction [CDKN1A protein binds to CDK2 protein]; SB 203580 inhibits the reaction [esculetin results in decreased expression of CDK2 protein]		 CTD PMID:21600278 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression
multiple interactions		 EXP esculetin results in decreased expression of CDK4 protein
esculetin promotes the reaction [CDKN1A protein binds to CDK4 protein]; SB 203580 inhibits the reaction [esculetin results in decreased expression of CDK4 protein]		 CTD PMID:21600278 NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression		 EXP
ISO		 esculetin promotes the reaction [CDKN1A protein binds to CDK2 protein]; esculetin promotes the reaction [CDKN1A protein binds to CDK4 protein]; SB 203580 inhibits the reaction [esculetin results in increased expression of CDKN1A protein] CTD PMID:21600278, PMID:31313495 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO esculetin results in increased expression of CDKN1B protein CTD PMID:31313495 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964 		JBrowse link
G Comt catechol-O-methyltransferase increases methylation ISO COMT protein results in increased methylation of esculetin CTD PMID:11160877 NCBI chr11:86,715,981...86,735,630
Ensembl chr11:86,715,981...86,735,622 		JBrowse link
G Cycs cytochrome c, somatic multiple interactions ISO [arsenic trioxide co-treated with esculetin] affects the localization of CYCS protein; [esculetin co-treated with Paclitaxel] affects the localization of CYCS protein CTD PMID:16051289, PMID:19428345 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326 		JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO [esculetin co-treated with Paclitaxel] results in increased expression of FAS protein CTD PMID:16051289 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790 		JBrowse link
G Faslg Fas ligand multiple interactions ISO [esculetin co-treated with Paclitaxel] results in increased expression of FASLG protein CTD PMID:16051289 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705 		JBrowse link
G Fasn fatty acid synthase multiple interactions ISO esculetin promotes the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of FASN mRNA] CTD PMID:27769711 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901 		JBrowse link
G Fn1 fibronectin 1 multiple interactions EXP esculetin inhibits the reaction [Streptozocin results in increased expression of FN1 mRNA]; esculetin inhibits the reaction [Streptozocin results in increased expression of FN1 protein] CTD PMID:21450970 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078 		JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 multiple interactions ISO esculetin promotes the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased activity of G6PC protein] CTD PMID:27769711 NCBI chr10:89,286,009...89,296,213
Ensembl chr10:89,285,855...89,296,213 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO esculetin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of IL6 mRNA]; esculetin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of IL6 protein] CTD PMID:27769711 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation		 ISO
EXP		 [esculetin co-treated with Paclitaxel] results in decreased expression of MAPK1 protein; esculetin results in decreased phosphorylation of and results in decreased activity of MAPK1 protein
esculetin results in increased phosphorylation of MAPK1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [esculetin results in increased phosphorylation of MAPK1 protein]; SB 203580 inhibits the reaction [esculetin results in increased phosphorylation of MAPK1 protein]		 CTD PMID:16051289, PMID:21600278, PMID:24995577 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO [esculetin co-treated with Paclitaxel] results in decreased expression of MAPK14 protein; esculetin results in decreased phosphorylation of and results in decreased activity of MAPK14 protein CTD PMID:16051289 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation		 ISO
EXP		 [esculetin co-treated with Paclitaxel] results in decreased expression of MAPK3 protein; esculetin results in decreased phosphorylation of and results in decreased activity of MAPK3 protein
esculetin results in increased phosphorylation of MAPK3 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [esculetin results in increased phosphorylation of MAPK3 protein]; SB 203580 inhibits the reaction [esculetin results in increased phosphorylation of MAPK3 protein]		 CTD PMID:16051289, PMID:21600278, PMID:24995577 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions
increases phosphorylation
increases expression		 ISO [esculetin co-treated with Paclitaxel] results in increased expression of MAPK8 protein
esculetin results in increased phosphorylation of MAPK8 protein
esculetin results in increased expression of MAPK8 protein		 CTD PMID:16051289, PMID:19786087 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions
increases expression		 ISO [esculetin co-treated with Paclitaxel] results in increased expression of MAPK9 protein
esculetin results in increased expression of MAPK9 protein		 CTD PMID:16051289 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355 		JBrowse link
G Mmp13 matrix metallopeptidase 13 multiple interactions EXP esculetin inhibits the reaction [Streptozocin results in increased expression of MMP13 mRNA] CTD PMID:21450970 NCBI chr 8:5,522,739...5,533,018
Ensembl chr 8:5,522,739...5,533,018 		JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions ISO esculetin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of MYD88 mRNA] CTD PMID:27769711 NCBI chr 8:128,022,512...128,027,462
Ensembl chr 8:128,022,473...128,026,841 		JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases localization
affects localization		 ISO esculetin results in increased localization of NFE2L2 protein
esculetin affects the localization of NFE2L2 protein		 CTD PMID:20933534, PMID:30171828 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 affects localization ISO esculetin affects the localization of NFKB1 protein CTD PMID:30171828 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO esculetin promotes the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA] CTD PMID:16212885 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190 		JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions EXP esculetin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of NOS3 mRNA]; esculetin inhibits the reaction [Dietary Fats results in decreased expression of NOS3 mRNA] CTD PMID:28946194 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases expression		 ISO esculetin results in increased expression of and results in increased activity of NQO1 protein
esculetin results in increased expression of NQO1 mRNA		 CTD PMID:20933534 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO esculetin results in increased cleavage of PARP1 protein CTD PMID:26388407, PMID:31313495 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions EXP
ISO		 esculetin inhibits the reaction [Streptozocin results in decreased expression of PPARG protein]; esculetin inhibits the reaction [Streptozocin results in increased expression of PPARG protein]
esculetin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of PPARG mRNA]		 CTD PMID:21450970, PMID:27769711 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit affects localization ISO esculetin affects the localization of RELA protein CTD PMID:30171828 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G Sod1 superoxide dismutase 1 affects expression ISO esculetin affects the expression of SOD1 protein CTD PMID:30171828 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862 		JBrowse link
G Sp1 Sp1 transcription factor decreases expression ISO esculetin results in decreased expression of SP1 protein CTD PMID:31313495 NCBI chr 7:144,014,173...144,044,635
Ensembl chr 7:144,014,173...144,044,629 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP esculetin inhibits the reaction [Streptozocin results in increased expression of TGFB1 protein] CTD PMID:21450970 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO esculetin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of TLR4 mRNA] CTD PMID:27769711 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO esculetin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of TNF mRNA]; esculetin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of TNF protein] CTD PMID:27769711 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Tnfrsf10b TNF receptor superfamily member 10b increases expression ISO esculetin results in increased expression of TNFRSF10A protein CTD PMID:19786087 NCBI chr15:51,433,853...51,464,215 JBrowse link
G Tp53 tumor protein p53 increases degradation
increases expression		 ISO esculetin results in increased degradation of TP53 protein
esculetin results in increased expression of TP53 protein		 CTD PMID:14634213, PMID:31313495 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449 		JBrowse link
G Ugt2b35 UDP glucuronosyltransferase 2 family, polypeptide B35 increases metabolic processing EXP UGT2B15 protein results in increased metabolism of esculetin CTD PMID:7574722 NCBI chr14:22,553,633...22,591,461
Ensembl chr14:22,553,650...22,591,461 		JBrowse link
G Usp16 ubiquitin specific peptidase 16 multiple interactions EXP esculetin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of USP16 mRNA]; esculetin inhibits the reaction [Dietary Fats results in increased expression of USP16 mRNA] CTD PMID:28946194 NCBI chr11:27,101,213...27,130,345
Ensembl chr11:27,101,227...27,130,341 		JBrowse link
G Usp22 ubiquitin specific peptidase 22 multiple interactions EXP esculetin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of USP22 mRNA]; esculetin inhibits the reaction [Dietary Fats results in increased expression of USP22 mRNA] CTD PMID:28946194 NCBI chr10:47,429,201...47,453,298
Ensembl chr10:47,429,002...47,453,442 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions EXP esculetin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of VCAM1 mRNA]; esculetin inhibits the reaction [Dietary Fats results in increased expression of VCAM1 mRNA] CTD PMID:28946194 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619 		JBrowse link
ethyl biscoumacetate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F10 coagulation factor X multiple interactions
decreases expression		 EXP Vitamin K 3 inhibits the reaction [Ethyl Biscoumacetate results in decreased expression of F10 protein] CTD PMID:6768192 NCBI chr16:81,803,169...81,822,476
Ensembl chr16:81,803,110...81,822,716 		JBrowse link
fraxetin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator decreases expression ISO fraxetin results in decreased expression of BAX protein CTD PMID:15996779 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Casp3 caspase 3 decreases activity ISO fraxetin results in decreased activity of CASP3 protein CTD PMID:15996779 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Casp9 caspase 9 decreases activity ISO fraxetin results in decreased activity of CASP9 protein CTD PMID:15996779 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778 		JBrowse link
G Cat catalase multiple interactions ISO fraxetin inhibits the reaction [Rotenone results in increased expression of and results in increased activity of CAT protein] CTD PMID:15904944 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058 		JBrowse link
G Cycs cytochrome c, somatic affects localization ISO fraxetin affects the localization of CYCS protein CTD PMID:15996779 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO fraxetin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL6 mRNA] CTD PMID:30496664 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO fraxetin inhibits the reaction [Rotenone results in increased expression of and results in increased activity of SOD2 protein] CTD PMID:15904944 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO fraxetin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of TNF mRNA] CTD PMID:30496664 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
glycycoumarin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pparg peroxisome proliferator-activated receptor gamma affects binding ISO glycycoumarin binds to PPARG protein CTD PMID:14608046 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380 		JBrowse link
glycyrin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dyrk1a dual specificity tyrosine phosphorylation regulated kinase 1A decreases activity ISO glycyrin results in decreased activity of DYRK1A protein CTD PMID:31838052 NCBI chr11:34,858,339...34,958,733
Ensembl chr11:34,865,532...34,956,536 		JBrowse link
LY294002 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases expression ISO
EXP		 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of ABCB1 mRNA; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of ABCB1 protein CTD PMID:23466342, PMID:27888070 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515 		JBrowse link
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B multiple interactions
decreases expression		 ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[NFKB1 protein binds to RELA protein] which results in increased expression of ABCB1B mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Curcumin results in decreased expression of ABCB1B protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of ABCB1B protein		 CTD PMID:18006147 NCBI chr 4:22,225,123...22,307,577
Ensembl chr 4:22,133,521...22,425,515 		JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 decreases expression EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of ABCC1 protein CTD PMID:27888070 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [erucin results in increased expression of ABCC2 mRNA] CTD PMID:15896333 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252 		JBrowse link
G Abcc5 ATP binding cassette subfamily C member 5 decreases expression ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of ABCC5 protein CTD PMID:23994249 NCBI chr11:84,395,982...84,490,215
Ensembl chr11:84,396,033...84,490,211 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ERBB2 results in increased expression of ABCG2 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ERBB2 results in increased expression of ABCG2 protein] CTD PMID:21712253 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621 		JBrowse link
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[BCR protein mutant form binds to ABL1 protein mutant form] which results in increased chemical synthesis of Histamine]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[BCR protein mutant form binds to ABL1 protein mutant form] which results in increased expression of HDC mRNA] CTD PMID:16849647 NCBI chr 3:10,041,820...10,145,076
Ensembl chr 3:10,041,826...10,144,388 		JBrowse link
G Acvr2b activin A receptor type 2B multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of ACVR2B mRNA] CTD PMID:12710931 NCBI chr 8:128,087,308...128,126,776
Ensembl chr 8:128,087,345...128,118,746 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Carbon Monoxide results in increased expression of ADIPOQ protein] which results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Carbon Monoxide results in increased expression of ADIPOQ protein] which results in increased phosphorylation of NOS3 protein] CTD PMID:19356108 NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488 		JBrowse link
G Adra1a adrenoceptor alpha 1A multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[cirazoline results in increased activity of ADRA1A protein] which results in increased transport of Glucose] CTD PMID:15550506 NCBI chr15:43,296,997...43,398,314
Ensembl chr15:43,298,794...43,392,451 		JBrowse link
G Ager advanced glycosylation end product-specific receptor multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Vitamin A results in increased expression of AGER protein] CTD PMID:21807062 NCBI chr20:4,363,152...4,366,079
Ensembl chr20:4,363,152...4,366,079 		JBrowse link
G Agt angiotensinogen multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [AGT protein inhibits the reaction [Glycochenodeoxycholic Acid results in increased activity of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [AGT protein results in increased cleavage of SREBF1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [AGT protein results in increased expression of POSTN mRNA] CTD PMID:15121739, PMID:16325820, PMID:23300732, PMID:25398788 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433 		JBrowse link
G Ahr aryl hydrocarbon receptor increases expression
multiple interactions
decreases expression		 EXP
ISO		 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of AHR mRNA; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of AHR protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein results in increased activity of AHR protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of AHR mRNA		 CTD PMID:22406437, PMID:27020609 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464 		JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin results in increased expression of AKR1B1 mRNA] CTD PMID:17640564 NCBI chr 4:61,706,866...61,720,959
Ensembl chr 4:61,706,864...61,720,956 		JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 decreases expression ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of AKR1B10 protein CTD PMID:23994249 NCBI chr 4:61,813,265...61,830,371
Ensembl chr 4:61,771,970...61,828,657 		JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cadmium acetate results in increased expression of AKR1C3 protein] CTD PMID:21787718 NCBI chr17:69,761,126...69,778,021
Ensembl chr17:69,761,118...69,778,021 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases expression
decreases phosphorylation
multiple interactions
decreases expression
decreases activity		 ISO
EXP		 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of AKT1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of AKT1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltiprotoporphyrin promotes the reaction [Lipopolysaccharides results in increased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Estradiol results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IL4 protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Isoproterenol results in increased phosphorylation of and results in increased activity of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LEPR gene mutant form results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Mercuric Chloride results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Methylmercury Compounds results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Phospholipids results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Quercetin inhibits the reaction [Okadaic Acid results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [RELN protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Toluene 2,4-Diisocyanate results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tretinoin results in increased activity of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Dexamethasone results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Melatonin inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased activity of and results in decreased phosphorylation of AKT1 protein; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with HRAS protein] results in decreased phosphorylation of AKT1 protein; [Butyrates co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in decreased phosphorylation of AKT1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of AKT1 mRNA
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the localization of [PDK1 protein binds to AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of AKT1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [2,3',4,4',5-pentachlorobiphenyl results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of and results in increased activity of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [4-hydroxyestradiol results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Cholesterol, HDL results in increased phosphorylation of and results in increased activity of AKT1 protein] which results in decreased degradation of NOS3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Clioquinol co-treated with Copper] results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[FGF7 protein results in increased phosphorylation of AKT1 protein] which results in increased expression of ESR1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[HSPA1A protein co-treated with Formaldehyde] results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[MIR21 mRNA results in decreased susceptibility to Cisplatin] which results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Rosiglitazone co-treated with IAPP protein] results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Acetylcysteine results in increased activity of and results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [arsenite results in increased activity of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [arsenite results in increased phosphorylation of and results in increased activity of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Atrazine results in decreased expression of and results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [BDNF protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [bisphenol A results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased cleavage of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Caffeine results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Camptothecin results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Capsaicin results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cholesterol, HDL results in increased phosphorylation of and results in increased activity of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Copper results in increased phosphorylation of and results in increased activity of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Copper Sulfate results in increased phosphorylation of and results in increased activity of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cotinine results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cyanoginosin LR results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [DEFA1 protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [DEFA2 protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Diethylhexyl Phthalate results in increased expression of AKT1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Diethylhexyl Phthalate results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Dronabinol results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Endosulfan results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Estradiol results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [FGF2 protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Furazolidone results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [gadodiamide results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rb1 results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [GW0742 results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [hemistepsin results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [INS protein results in increased expression of AKT1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [INS protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [KMUP 1 results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [methanandamide results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [nickel chloride results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Nicotine results in increased phosphorylation of and results in increased activity of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Nifedipine promotes the reaction [[Hydrogen Peroxide co-treated with Simvastatin] results in increased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NLRC5 protein results in increased expression of AKT1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NLRC5 protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Paclitaxel results in increased activity of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Particulate Matter results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Phosphates results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Polychlorinated Biphenyls analog results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [propazine results in decreased expression of and results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [PTK2 protein promotes the reaction [Doxorubicin results in increased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol inhibits the reaction [Glucose results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Simazine results in decreased expression of and results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Simvastatin promotes the reaction [[Nifedipine co-treated with Hydrogen Peroxide] results in increased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Simvastatin results in increased phosphorylation of and results in increased activity of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [spiraeoside inhibits the reaction [Glucose results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [stearic acid results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [terbutylazine results in decreased expression of and results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Thapsigargin results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [titanium dioxide results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TNF protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tretinoin results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ursodeoxycholic Acid results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Vehicle Emissions results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Zinc results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Zinc results in increased phosphorylation of and results in increased activity of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Zinc Sulfate results in increased phosphorylation of and results in increased activity of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Arsenic Trioxide results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Cisplatin results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [di-n-propyldithiocarbamate results in decreased expression of and results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [kahweol results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Oligopeptides analog results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [polyphenon E results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [pristimerin results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [rhodojaponin II inhibits the reaction [TNF protein results in increased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Simvastatin results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of and results in decreased phosphorylation of AKT1 protein; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of and results in decreased activity of AKT1 protein; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Benzo(a)pyrene] results in decreased phosphorylation of AKT1 protein; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Quercetin] inhibits the reaction [INS protein results in increased phosphorylation of AKT1 protein]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Quercetin] results in decreased phosphorylation of AKT1 protein; [Doxorubicin co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in decreased phosphorylation of AKT1 protein; [Formaldehyde co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in decreased phosphorylation of AKT1 protein; [PDK1 protein binds to AKT1 protein] inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of AKT1 protein]; [PDK1 protein binds to AKT1 protein] inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of RPS6 protein]; [PDK1 protein binds to AKT1 protein] results in decreased susceptibility to [Paclitaxel co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one]; [PDK1 protein binds to AKT1 protein] which results in decreased susceptibility to 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one; [Sirolimus co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in decreased phosphorylation of AKT1 protein; [sodium arsenite co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in decreased phosphorylation of AKT1 protein; Arsenic Trioxide promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of AKT1 protein]; Cisplatin promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of AKT1 protein]; kahweol promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of AKT1 protein]; polyphenon E promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of AKT1 protein]; Simvastatin promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of AKT1 protein]; Tamoxifen promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of AKT1 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased activity of AKT1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[5-aminoisoquinolinone co-treated with Hydrogen Peroxide] results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Capsaicin co-treated with Oxygen deficiency co-treated with Oxygen] results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Carbon Monoxide results in increased expression of ADIPOQ protein] which results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Selegiline co-treated with 1-Methyl-4-phenylpyridinium] results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carnitine results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cilomilast promotes the reaction [Nitroprusside results in increased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [deuterohemin-alanyl-histidyl-threonyl-valyl-glutamyl-lysine inhibits the reaction [Glucose results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [deuterohemin-alanyl-histidyl-threonyl-valyl-glutamyl-lysine results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [diallyl trisulfide inhibits the reaction [Glucose results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Doxepin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased activity of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Epirubicin results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ferrous sulfate results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rg2 inhibits the reaction [APP protein modified form results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Glucose results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [GRN protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein inhibits the reaction [Isoflurane results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [INS1 protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Iron results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Isoproterenol results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LHCGR protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Mevinphos results in increased activity of and results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [MT2A protein inhibits the reaction [Tunicamycin results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [naringin results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NGF protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Quercetin inhibits the reaction [[Dithionite co-treated with Glucose deficiency] results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol inhibits the reaction [Glucose results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rhodioloside inhibits the reaction [Colistin results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Roflumilast promotes the reaction [Nitroprusside results in increased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Rolipram promotes the reaction [Nitroprusside results in increased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvianolic acid B results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Sevoflurane results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Smoke analog results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Thapsigargin results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Triiodothyronine results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tunicamycin results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Vitamin A results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [[Dithionite co-treated with Glucose deficiency] results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [APP protein modified form results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Tunicamycin results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of and results in decreased activity of AKT1 protein; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in decreased phosphorylation of AKT1 protein; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Tretinoin] results in decreased phosphorylation of AKT1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of AKT1 protein		 CTD PMID:11306697, PMID:11788791, PMID:12438947, PMID:12511591, PMID:12556562, PMID:12640124, PMID:12710931, PMID:12821261, PMID:12834810, PMID:14755253, PMID:14757120, PMID:14762343, PMID:15001399, PMID:15028728, PMID:15050414, PMID:15177934, PMID:15178407, PMID:15213310, PMID:15339911, PMID:15631803, PMID:15695173, PMID:15845746, PMID:15897870, PMID:15919668, PMID:15956784, PMID:16018989, PMID:16059913, PMID:16168102, PMID:16179367, PMID:16204373, PMID:16211241, PMID:16256798, PMID:16275998, PMID:16288212, PMID:16343977, PMID:16434995, PMID:16472761, PMID:16619521, PMID:16648635, PMID:16682453, PMID:16731823, PMID:16763222, PMID:16973122, PMID:17172471, PMID:17259349, PMID:17324588, PMID:17346750, PMID:17464197, PMID:17513037, PMID:17550345, PMID:17583570, PMID:17623046, PMID:17823925, PMID:17922026, PMID:17962351, PMID:18096819, PMID:18201823, PMID:18276108, PMID:18359480, PMID:18388193, PMID:18622747, PMID:18948619, PMID:19011674, PMID:19038232, PMID:19059400, PMID:19073151, PMID:19139269, PMID:19176369, PMID:19233221, PMID:19299917, PMID:19356108, PMID:19457607, PMID:19561517, PMID:19661335, PMID:19781563, PMID:19814765, PMID:19881297, PMID:19906781, PMID:19956873, PMID:19962417, PMID:20361045, PMID:20386985, PMID:20464445, PMID:20562903, PMID:20600219, PMID:20610540, PMID:20657188, PMID:20658310, PMID:20938987, PMID:21055460, PMID:21138475, PMID:21474332, PMID:21594580, PMID:21655183, PMID:21803128, PMID:21807062, PMID:21820214, PMID:21821001, PMID:21837363, PMID:21976531, PMID:22019741, PMID:22040890, PMID:22046442, PMID:22545124, PMID:22556157, PMID:22687995, PMID:23000059, PMID:23159718, PMID:23285096, PMID:23300809, PMID:23352507, PMID:23453443, PMID:23466500, PMID:23735482, PMID:23793038, PMID:23880231, PMID:23958495, PMID:24057571, PMID:24122885, PMID:24361488, PMID:24449419, PMID:24462917, PMID:24680926, PMID:24727557, PMID:24875536, PMID:24876378, PMID:24898257, PMID:24946264, PMID:25118938, PMID:25171655, PMID:25203460, PMID:25303017, PMID:25398788, PMID:25471227, PMID:25597859, PMID:25644787, PMID:25773745, PMID:25866362, PMID:26048653, PMID:26089345, PMID:26282490, PMID:26364587, PMID:26506538, PMID:26687534, PMID:26790143, PMID:26942697, PMID:26974319, PMID:27049278, PMID:27050422, PMID:27295300, PMID:27312872, PMID:27338800, PMID:27431321, PMID:27542212, PMID:27658547, PMID:28302560, PMID:28465020, PMID:28756148, PMID:28940008, PMID:29061316, PMID:29186614, PMID:29505745, PMID:29510123, PMID:30205135, PMID:30600586, PMID:30726812, PMID:30851366, PMID:31068539, PMID:31445927, PMID:31715269, PMID:31743544, PMID:31830547, PMID:32044604, PMID:32602595, PMID:32613688, PMID:32687844 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258 		JBrowse link
G Akt1s1 AKT1 substrate 1 decreases phosphorylation EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of AKT1S1 protein CTD