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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:phenprocoumon
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Accession:CHEBI:50438 term browser browse the term
Definition:A hydroxycoumarin that is 4-hydroxycoumarin which is substituted at position 3 by a 1-phenylpropyl group.
Synonyms:related_synonym: 3-(1'-Phenyl-propyl)-4-oxycoumarin;   3-(1-Phenylpropyl)-4-hydroxycoumarin;   3-(alpha-Ethylbenzyl)-4-hydroxycoumarin;   3-(alpha-Phenylpropyl)-4-hydroxycoumarin;   4-Hydroxy-3-(1-phenylpropyl)-2H-1-benzopyran-2-one;   4-hydroxy-3-(1-phenylpropyl)-2H-chromen-2-one;   Fenprocumone;   Formula=C18H16O3;   InChI=1S/C18H16O3/c1-2-13(12-8-4-3-5-9-12)16-17(19)14-10-6-7-11-15(14)21-18(16)20/h3-11,13,19H,2H2,1H3;   InChIKey=DQDAYGNAKTZFIW-UHFFFAOYSA-N;   Phenprocoumarol;   Phenprocoumarole;   Phenprocumone;   SMILES=CCC(c1ccccc1)c1c(O)c2ccccc2oc1=O;   fenprocumon;   phenprocoumone;   phenprocoumonum
 alt_id: CHEBI:494229
 xref: Beilstein:1291115;   CAS:435-97-2;   DrugBank:DB00946;   Drug_Central:2138;   KEGG:D05457
 xref_mesh: MESH:D010644
 xref: PMID:17275317;   Patent:GB805748;   Patent:US2723276;   Patent:US2872457;   Patent:US3239529;   Reaxys:1291115


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phenprocoumon term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F10 coagulation factor X decreases activity EXP Phenprocoumon results in decreased activity of F10 protein CTD PMID:3490277 NCBI chr16:81,803,169...81,822,476
Ensembl chr16:81,803,110...81,822,716
JBrowse link
G F2 coagulation factor II decreases activity EXP Phenprocoumon results in decreased activity of F2 protein CTD PMID:3490277 NCBI chr 3:80,529,468...80,542,993
Ensembl chr 3:80,529,428...80,543,031
JBrowse link
G F5 coagulation factor V decreases activity EXP Phenprocoumon results in decreased activity of F5 protein CTD PMID:3490277 NCBI chr13:82,479,997...82,535,540
Ensembl chr13:82,479,998...82,535,534
JBrowse link
G F7 coagulation factor VII decreases activity EXP Phenprocoumon results in decreased activity of F7 protein CTD PMID:3490277 NCBI chr16:81,824,610...81,834,923
Ensembl chr16:81,824,111...81,834,945
JBrowse link
G F9 coagulation factor IX decreases activity EXP Phenprocoumon results in decreased activity of F9 protein CTD PMID:3490277 NCBI chr  X:143,097,507...143,141,791
Ensembl chr  X:143,097,525...143,141,794
JBrowse link
G Ggcx gamma-glutamyl carboxylase increases activity EXP Phenprocoumon results in increased activity of GGCX protein CTD PMID:3490277 NCBI chr 4:100,277,345...100,293,097
Ensembl chr 4:100,277,391...100,293,250
JBrowse link
G Vkorc1 vitamin K epoxide reductase complex, subunit 1 affects response to substance
decreases activity
multiple interactions
decreases response to substance
ISO VKORC1 gene polymorphism affects the susceptibility to Phenprocoumon; VKORC1 intron SNP affects the susceptibility to Phenprocoumon
Phenprocoumon results in decreased activity of VKORC1 protein
Phenprocoumon inhibits the reaction [VKORC1 protein results in increased reduction of Vitamin K 1]
VKORC1 protein polymorphism results in decreased susceptibility to Phenprocoumon
CTD PMID:15536456, PMID:16201835, PMID:17036862, PMID:18698879, PMID:29581108 NCBI chr 1:199,338,785...199,341,306
Ensembl chr 1:199,337,138...199,341,302
JBrowse link
G Vkorc1l1 vitamin K epoxide reductase complex, subunit 1-like 1 decreases activity
multiple interactions
ISO Phenprocoumon results in decreased activity of VKORC1L1 protein
Phenprocoumon inhibits the reaction [VKORC1L1 protein results in increased reduction of Vitamin K 1]
CTD PMID:29581108 NCBI chr12:30,218,825...30,268,990
Ensembl chr12:30,222,701...30,268,990
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19792
    role 19738
      application 19385
        pharmaceutical 19255
          drug 19255
            hematologic agent 4364
              anticoagulant 4157
                phenprocoumon 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 19792
    subatomic particle 19788
      composite particle 19788
        hadron 19788
          baryon 19788
            nucleon 19788
              atomic nucleus 19788
                atom 19788
                  main group element atom 19675
                    p-block element atom 19675
                      carbon group element atom 19571
                        carbon atom 19560
                          organic molecular entity 19560
                            organic molecule 19483
                              organic cyclic compound 19252
                                organic heterocyclic compound 18422
                                  oxacycle 17197
                                    benzopyran 10139
                                      1-benzopyran 9853
                                        chromenes 926
                                          chromenone 844
                                            coumarins 562
                                              hydroxycoumarin 299
                                                phenprocoumon 8
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