Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:phenprocoumon
go back to main search page
Accession:CHEBI:50438 term browser browse the term
Definition:A hydroxycoumarin that is 4-hydroxycoumarin which is substituted at position 3 by a 1-phenylpropyl group.
Synonyms:related_synonym: 3-(1'-Phenyl-propyl)-4-oxycoumarin;   3-(1-Phenylpropyl)-4-hydroxycoumarin;   3-(alpha-Ethylbenzyl)-4-hydroxycoumarin;   3-(alpha-Phenylpropyl)-4-hydroxycoumarin;   4-Hydroxy-3-(1-phenylpropyl)-2H-1-benzopyran-2-one;   4-hydroxy-3-(1-phenylpropyl)-2H-chromen-2-one;   Fenprocumone;   Formula=C18H16O3;   InChI=1S/C18H16O3/c1-2-13(12-8-4-3-5-9-12)16-17(19)14-10-6-7-11-15(14)21-18(16)20/h3-11,13,19H,2H2,1H3;   InChIKey=DQDAYGNAKTZFIW-UHFFFAOYSA-N;   Phenprocoumarol;   Phenprocoumarole;   Phenprocumone;   SMILES=CCC(c1ccccc1)c1c(O)c2ccccc2oc1=O;   fenprocumon;   phenprocoumone;   phenprocoumonum
 alt_id: CHEBI:494229
 xref: Beilstein:1291115;   CAS:435-97-2;   DrugBank:DB00946;   Drug_Central:2138;   KEGG:D05457
 xref_mesh: MESH:D010644
 xref: PMID:17275317;   Patent:GB805748;   Patent:US2723276;   Patent:US2872457;   Patent:US3239529;   Reaxys:1291115



show annotations for term's descendants           Sort by:
 
phenprocoumon term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F10 coagulation factor X decreases activity EXP Phenprocoumon results in decreased activity of F10 protein CTD PMID:3490277 NCBI chr16:76,468,834...76,488,141
Ensembl chr16:76,468,838...76,488,141
JBrowse link
G F2 coagulation factor II decreases activity EXP Phenprocoumon results in decreased activity of F2 protein CTD PMID:3490277 NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486
JBrowse link
G F5 coagulation factor V decreases activity EXP Phenprocoumon results in decreased activity of F5 protein CTD PMID:3490277 NCBI chr13:76,513,463...76,583,106
Ensembl chr13:76,513,255...76,582,317
JBrowse link
G F7 coagulation factor VII decreases activity EXP Phenprocoumon results in decreased activity of F7 protein CTD PMID:3490277 NCBI chr16:76,489,779...76,500,636
Ensembl chr16:76,489,717...76,500,610
JBrowse link
G F9 coagulation factor IX decreases activity EXP Phenprocoumon results in decreased activity of F9 protein CTD PMID:3490277 NCBI chr  X:138,352,334...138,396,835
Ensembl chr  X:138,352,298...138,396,835
JBrowse link
G Ggcx gamma-glutamyl carboxylase increases activity EXP Phenprocoumon results in increased activity of GGCX protein CTD PMID:3490277 NCBI chr 4:104,469,737...104,485,631
Ensembl chr 4:104,469,765...104,487,063
JBrowse link
G Hsf1 heat shock transcription factor 1 decreases activity ISO Phenprocoumon results in decreased activity of HSF1 protein CTD PMID:34170685 NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011
JBrowse link
G Vkorc1 vitamin K epoxide reductase complex, subunit 1 affects response to substance
decreases activity
multiple interactions
decreases response to substance
ISO VKORC1 gene polymorphism affects the susceptibility to Phenprocoumon; VKORC1 intron SNP affects the susceptibility to Phenprocoumon
Phenprocoumon results in decreased activity of VKORC1 protein
Phenprocoumon inhibits the reaction [VKORC1 protein results in increased reduction of Vitamin K 1]
VKORC1 protein polymorphism results in decreased susceptibility to Phenprocoumon
CTD PMID:15536456 PMID:16201835 PMID:17036862 PMID:18698879 PMID:29581108 NCBI chr 1:182,502,491...182,505,012
Ensembl chr 1:182,500,844...182,505,008
JBrowse link
G Vkorc1l1 vitamin K epoxide reductase complex, subunit 1-like 1 decreases activity
multiple interactions
ISO Phenprocoumon results in decreased activity of VKORC1L1 protein
Phenprocoumon inhibits the reaction [VKORC1L1 protein results in increased reduction of Vitamin K 1]
CTD PMID:29581108 NCBI chr12:26,717,959...26,768,193 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    role 19751
      application 19498
        pharmaceutical 19356
          drug 19356
            hematologic agent 4405
              anticoagulant 4187
                phenprocoumon 9
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      carbon group element atom 19619
                        carbon atom 19609
                          organic molecular entity 19609
                            organic molecule 19549
                              organic cyclic compound 19343
                                organic heterocyclic compound 18584
                                  oxacycle 17609
                                    benzopyran 11162
                                      1-benzopyran 10903
                                        chromenes 3026
                                          chromenone 2966
                                            coumarins 2720
                                              hydroxycoumarin 333
                                                phenprocoumon 9
paths to the root