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G |
Acaa1a |
acetyl-CoA acyltransferase 1A |
multiple interactions |
EXP |
Scopoletin inhibits the reaction [Ethanol results in decreased expression of ACAA1A mRNA] |
CTD |
PMID:26115886 |
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NCBI chr 8:119,079,401...119,088,626
Ensembl chr 8:119,079,775...119,088,624
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G |
Acaca |
acetyl-CoA carboxylase alpha |
multiple interactions |
EXP |
Scopoletin inhibits the reaction [Ethanol results in decreased phosphorylation of ACACA protein] |
CTD |
PMID:26115886 |
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NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
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G |
Acox1 |
acyl-CoA oxidase 1 |
multiple interactions |
EXP |
Scopoletin inhibits the reaction [Ethanol results in decreased expression of ACOX1 mRNA] |
CTD |
PMID:26115886 |
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NCBI chr10:101,406,197...101,431,252
Ensembl chr10:101,406,197...101,431,232
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G |
Acsl1 |
acyl-CoA synthetase long-chain family member 1 |
multiple interactions |
EXP |
Scopoletin inhibits the reaction [Ethanol results in decreased expression of ACSL1 mRNA] |
CTD |
PMID:26115886 |
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NCBI chr16:45,755,246...45,821,541
Ensembl chr16:45,755,254...45,821,541
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G |
Adipoq |
adiponectin, C1Q and collagen domain containing |
multiple interactions |
EXP |
Scopoletin inhibits the reaction [Ethanol results in decreased expression of ADIPOQ mRNA]; Scopoletin inhibits the reaction [Ethanol results in decreased expression of ADIPOQ protein] |
CTD |
PMID:26115886 |
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NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
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G |
Adipor2 |
adiponectin receptor 2 |
multiple interactions increases expression |
EXP |
Scopoletin inhibits the reaction [Ethanol results in decreased expression of ADIPOR2 mRNA]; Scopoletin inhibits the reaction [Ethanol results in decreased expression of ADIPOR2 protein] scopoletin increases expression of adipor2 mRNA and protein in epididymal white adipose tissue of alcohol fed rats |
CTD RGD |
PMID:26115886 PMID:26115886 |
RGD:25330099 |
NCBI chr 4:152,524,604...152,588,848
Ensembl chr 4:152,524,623...152,559,355
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G |
Atf4 |
activating transcription factor 4 |
decreases expression |
EXP |
Scopoletin results in decreased expression of ATF4 mRNA |
CTD |
PMID:34979142 |
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NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
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G |
Casp3 |
caspase 3 |
multiple interactions |
EXP ISO |
Scopoletin inhibits the reaction [Glycochenodeoxycholic Acid results in increased activity of CASP3 protein] Scopoletin inhibits the reaction [Palmitic Acid results in increased activity of CASP3 protein] |
CTD |
PMID:34979142 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Cidea |
cell death-inducing DFFA-like effector a |
multiple interactions |
EXP |
Scopoletin inhibits the reaction [Alcohols affects the expression of CIDEA mRNA] |
CTD |
PMID:26115886 |
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NCBI chr18:60,894,917...60,920,485
Ensembl chr18:60,894,874...60,920,481
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G |
Ddit3 |
DNA-damage inducible transcript 3 |
multiple interactions |
EXP |
Scopoletin inhibits the reaction [Glycochenodeoxycholic Acid results in increased expression of DDIT3 mRNA]; Scopoletin inhibits the reaction [Palmitic Acid results in increased expression of DDIT3 mRNA] |
CTD |
PMID:34979142 |
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NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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G |
Fasn |
fatty acid synthase |
multiple interactions |
EXP |
Scopoletin inhibits the reaction [Ethanol results in increased expression of FASN mRNA] |
CTD |
PMID:26115886 |
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NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
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G |
Gpt |
glutamic--pyruvic transaminase |
multiple interactions |
EXP |
Scopoletin inhibits the reaction [Ethanol results in increased activity of GPT protein] |
CTD |
PMID:26115886 |
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NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
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G |
Hspa5 |
heat shock protein family A (Hsp70) member 5 |
multiple interactions increases expression |
EXP |
[Glycochenodeoxycholic Acid co-treated with Scopoletin] results in increased expression of HSPA5 mRNA; [Scopoletin co-treated with Palmitic Acid] results in increased expression of HSPA5 mRNA Scopoletin results in increased expression of HSPA5 mRNA |
CTD |
PMID:34979142 |
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NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
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G |
Il10 |
interleukin 10 |
multiple interactions |
EXP |
Scopoletin inhibits the reaction [Ethanol results in decreased expression of IL10 protein] |
CTD |
PMID:26115886 |
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NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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G |
Il6 |
interleukin 6 |
multiple interactions |
EXP |
Scopoletin inhibits the reaction [Ethanol results in increased expression of IL6 mRNA]; Scopoletin inhibits the reaction [Ethanol results in increased expression of IL6 protein] |
CTD |
PMID:26115886 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Lipe |
lipase E, hormone sensitive type |
multiple interactions |
EXP |
Scopoletin inhibits the reaction [Ethanol results in increased phosphorylation of LIPE protein] |
CTD |
PMID:26115886 |
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NCBI chr 1:80,965,612...80,984,313
Ensembl chr 1:80,965,627...80,984,310
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions |
EXP |
Scopoletin inhibits the reaction [Glycochenodeoxycholic Acid results in increased phosphorylation of MAPK1 protein]; Scopoletin inhibits the reaction [Palmitic Acid results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:34979142 |
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NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions |
EXP |
Scopoletin inhibits the reaction [Glycochenodeoxycholic Acid results in increased phosphorylation of MAPK3 protein]; Scopoletin inhibits the reaction [Palmitic Acid results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:34979142 |
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NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Mapk8 |
mitogen-activated protein kinase 8 |
multiple interactions |
EXP |
Scopoletin inhibits the reaction [Glycochenodeoxycholic Acid results in increased phosphorylation of MAPK8 protein]; Scopoletin inhibits the reaction [Palmitic Acid results in increased phosphorylation of MAPK8 protein] |
CTD |
PMID:34979142 |
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NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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G |
Myd88 |
MYD88, innate immune signal transduction adaptor |
multiple interactions |
EXP |
Scopoletin inhibits the reaction [Ethanol results in increased expression of MYD88 mRNA] |
CTD |
PMID:26115886 |
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NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415
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G |
Pnpla2 |
patatin-like phospholipase domain containing 2 |
multiple interactions |
EXP |
Scopoletin inhibits the reaction [Ethanol results in increased expression of PNPLA2 mRNA] |
CTD |
PMID:26115886 |
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NCBI chr 1:196,552,723...196,557,805
Ensembl chr 1:196,552,723...196,557,805
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G |
Ppara |
peroxisome proliferator activated receptor alpha |
multiple interactions |
EXP |
Scopoletin inhibits the reaction [Ethanol results in decreased expression of PPARA mRNA] |
CTD |
PMID:26115886 |
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NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
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G |
Srebf1 |
sterol regulatory element binding transcription factor 1 |
multiple interactions |
EXP |
Scopoletin inhibits the reaction [Ethanol results in increased expression of SREBF1 mRNA] |
CTD |
PMID:26115886 |
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NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
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G |
Ticam1 |
TIR domain containing adaptor molecule 1 |
multiple interactions |
EXP |
Scopoletin inhibits the reaction [Ethanol results in increased expression of TICAM1 mRNA] |
CTD |
PMID:26115886 |
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NCBI chr 9:1,102,559...1,111,023
Ensembl chr 9:1,102,366...1,123,147
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G |
Tlr4 |
toll-like receptor 4 |
multiple interactions |
EXP |
Scopoletin inhibits the reaction [Ethanol results in increased expression of TLR4 mRNA] |
CTD |
PMID:26115886 |
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NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
EXP |
Scopoletin inhibits the reaction [Ethanol results in increased expression of TNF mRNA]; Scopoletin inhibits the reaction [Ethanol results in increased expression of TNF protein] |
CTD |
PMID:26115886 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Ugt1a1 |
UDP glucuronosyltransferase family 1 member A1 |
increases glucuronidation |
ISO |
UGT1A1 protein results in increased glucuronidation of Scopoletin |
CTD |
PMID:15802387 |
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NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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G |
Ugt1a2 |
UDP glucuronosyltransferase 1 family, polypeptide A2 |
increases glucuronidation |
ISO |
UGT1A3 protein results in increased glucuronidation of Scopoletin |
CTD |
PMID:15802387 |
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NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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G |
Ugt1a6 |
UDP glucuronosyltransferase family 1 member A6 |
increases glucuronidation |
ISO |
UGT1A6 protein results in increased glucuronidation of Scopoletin |
CTD |
PMID:15802387 |
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NCBI chr 9:88,747,213...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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G |
Ugt1a9 |
UDP glucuronosyltransferase family 1 member A9 |
increases glucuronidation |
ISO |
UGT1A9 protein results in increased glucuronidation of Scopoletin |
CTD |
PMID:15044611 PMID:15802387 |
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NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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G |
Ugt2b15 |
UDP glucuronosyltransferase family 2 member B15 |
increases metabolic processing |
EXP |
UGT2B15 protein results in increased metabolism of Scopoletin |
CTD |
PMID:7574722 |
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NCBI chr14:20,768,015...20,783,599
Ensembl chr14:20,768,015...20,783,589
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G |
Xpc |
XPC complex subunit, DNA damage recognition and repair factor |
affects response to substance |
ISO |
XPC protein affects the susceptibility to Scopoletin |
CTD |
PMID:22280988 |
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NCBI chr 4:123,993,670...124,020,922
Ensembl chr 4:123,993,666...124,021,010
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G |
Ide |
insulin degrading enzyme |
multiple interactions |
ISO |
scopolin binds to and affects the activity of IDE protein |
CTD |
PMID:23146021 |
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NCBI chr 1:235,002,984...235,102,448
Ensembl chr 1:234,995,351...235,102,440
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G |
Urod |
uroporphyrinogen decarboxylase |
multiple interactions |
ISO |
scopolin binds to and affects the activity of UROD protein |
CTD |
PMID:23209648 |
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NCBI chr 5:130,464,695...130,468,783
Ensembl chr 5:130,455,217...130,468,808
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