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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:scopoletin
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Accession:CHEBI:17488 term browser browse the term
Definition:A hydroxycoumarin that is umbelliferone bearing a methoxy substituent at position 6.
Synonyms:exact_synonym: 7-hydroxy-6-methoxy-2H-chromen-2-one
 related_synonym: 6-Methoxy-7-hydroxycoumarin;   6-Methylesculetin;   6-O-Methylesculetin;   7-Hydroxy-6-methoxy-2H-1-benzopyran-2-one;   7-hydroxy-6-methoxycoumarin;   Formula=C10H8O4;   InChI=1S/C10H8O4/c1-13-9-4-6-2-3-10(12)14-8(6)5-7(9)11/h2-5,11H,1H3;   InChIKey=RODXRVNMMDRFIK-UHFFFAOYSA-N;   SMILES=COc1cc2ccc(=O)oc2cc1O
 alt_id: CHEBI:15067;   CHEBI:210840;   CHEBI:26611;   CHEBI:9057
 xref: CAS:92-61-5;   KEGG:C01752;   KNApSAcK:C00002499;   LINCS:LSM-6694
 xref_mesh: MESH:D012603
 xref: PMID:20686865;   PMID:21078410;   PMID:21163341;   PMID:21383663;   PMID:21417386;   PMID:21544717;   PMID:21598418;   PMID:21604276;   PMID:21605187;   PMID:21657075;   PMID:21751840;   Reaxys:156296


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scopoletin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaa1a acetyl-CoA acyltransferase 1A multiple interactions EXP Scopoletin inhibits the reaction [Ethanol results in decreased expression of ACAA1A mRNA] CTD PMID:26115886 NCBI chr 8:128,027,880...128,036,471
Ensembl chr 8:128,027,958...128,036,236
JBrowse link
G Acaca acetyl-CoA carboxylase alpha multiple interactions EXP Scopoletin inhibits the reaction [Ethanol results in decreased phosphorylation of ACACA protein] CTD PMID:26115886 NCBI chr10:71,519,392...71,719,910
Ensembl chr10:71,536,533...71,719,910
JBrowse link
G Acox1 acyl-CoA oxidase 1 multiple interactions EXP Scopoletin inhibits the reaction [Ethanol results in decreased expression of ACOX1 mRNA] CTD PMID:26115886 NCBI chr10:104,724,534...104,748,003
Ensembl chr10:104,722,958...104,748,050
JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 multiple interactions EXP Scopoletin inhibits the reaction [Ethanol results in decreased expression of ACSL1 mRNA] CTD PMID:26115886 NCBI chr16:48,937,456...49,003,898
Ensembl chr16:48,937,456...49,003,246
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions EXP Scopoletin inhibits the reaction [Ethanol results in decreased expression of ADIPOQ mRNA]; Scopoletin inhibits the reaction [Ethanol results in decreased expression of ADIPOQ protein] CTD PMID:26115886 NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488
JBrowse link
G Adipor2 adiponectin receptor 2 multiple interactions
increases expression
EXP Scopoletin inhibits the reaction [Ethanol results in decreased expression of ADIPOR2 mRNA]; Scopoletin inhibits the reaction [Ethanol results in decreased expression of ADIPOR2 protein]
scopoletin increases expression of adipor2 mRNA and protein in epididymal white adipose tissue of alcohol fed rats
CTD PMID:26115886, PMID:26115886 RGD:25330099 NCBI chr 4:151,412,135...151,480,108
Ensembl chr 4:151,414,684...151,428,894
JBrowse link
G Cidea cell death-inducing DFFA-like effector a multiple interactions EXP Scopoletin inhibits the reaction [Alcohols affects the expression of CIDEA mRNA] CTD PMID:26115886 NCBI chr18:63,082,861...63,108,450
Ensembl chr18:63,098,144...63,108,051
JBrowse link
G Fasn fatty acid synthase multiple interactions EXP Scopoletin inhibits the reaction [Ethanol results in increased expression of FASN mRNA] CTD PMID:26115886 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP Scopoletin inhibits the reaction [Ethanol results in increased activity of GPT protein] CTD PMID:26115886 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Il10 interleukin 10 multiple interactions EXP Scopoletin inhibits the reaction [Ethanol results in decreased expression of IL10 protein] CTD PMID:26115886 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il6 interleukin 6 multiple interactions EXP Scopoletin inhibits the reaction [Ethanol results in increased expression of IL6 mRNA]; Scopoletin inhibits the reaction [Ethanol results in increased expression of IL6 protein] CTD PMID:26115886 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Lipe lipase E, hormone sensitive type multiple interactions EXP Scopoletin inhibits the reaction [Ethanol results in increased phosphorylation of LIPE protein] CTD PMID:26115886 NCBI chr 1:82,248,031...82,266,727
Ensembl chr 1:82,248,046...82,266,727
JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions EXP Scopoletin inhibits the reaction [Ethanol results in increased expression of MYD88 mRNA] CTD PMID:26115886 NCBI chr 8:128,022,512...128,027,462
Ensembl chr 8:128,022,473...128,026,841
JBrowse link
G Pnpla2 patatin-like phospholipase domain containing 2 multiple interactions EXP Scopoletin inhibits the reaction [Ethanol results in increased expression of PNPLA2 mRNA] CTD PMID:26115886 NCBI chr 1:214,434,638...214,439,720
Ensembl chr 1:214,434,626...214,439,720
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions EXP Scopoletin inhibits the reaction [Ethanol results in decreased expression of PPARA mRNA] CTD PMID:26115886 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions EXP Scopoletin inhibits the reaction [Ethanol results in increased expression of SREBF1 mRNA] CTD PMID:26115886 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
JBrowse link
G Ticam1 toll-like receptor adaptor molecule 1 multiple interactions EXP Scopoletin inhibits the reaction [Ethanol results in increased expression of TICAM1 mRNA] CTD PMID:26115886 NCBI chr 9:10,780,185...10,790,280 JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions EXP Scopoletin inhibits the reaction [Ethanol results in increased expression of TLR4 mRNA] CTD PMID:26115886 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP Scopoletin inhibits the reaction [Ethanol results in increased expression of TNF mRNA]; Scopoletin inhibits the reaction [Ethanol results in increased expression of TNF protein] CTD PMID:26115886 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of Scopoletin CTD PMID:15802387 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of Scopoletin CTD PMID:15802387 NCBI chr 9:95,285,592...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 increases glucuronidation ISO UGT1A6 protein results in increased glucuronidation of Scopoletin CTD PMID:15802387 NCBI chr 9:95,241,609...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a8 UDP glucuronosyltransferase family 1 member A8 increases glucuronidation ISO UGT1A8 protein results in increased glucuronidation of Scopoletin CTD PMID:15802387 NCBI chr 9:95,221,474...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of Scopoletin CTD PMID:15044611, PMID:15802387 NCBI chr 9:95,161,157...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt2b15 UDP glucuronosyltransferase family 2 member B15 increases metabolic processing EXP UGT2B15 protein results in increased metabolism of Scopoletin CTD PMID:7574722 NCBI chr14:22,375,428...22,486,291
Ensembl chr14:22,375,955...22,534,720
JBrowse link
G Xpc XPC complex subunit, DNA damage recognition and repair factor affects response to substance ISO XPC protein affects the susceptibility to Scopoletin CTD PMID:22280988 NCBI chr 4:123,134,457...123,161,985
Ensembl chr 4:123,134,457...123,161,985
JBrowse link
scopolin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ide insulin degrading enzyme multiple interactions ISO scopolin binds to and affects the activity of IDE protein CTD PMID:23146021 NCBI chr 1:255,914,465...256,014,168
Ensembl chr 1:255,914,447...256,013,495
JBrowse link
G Urod uroporphyrinogen decarboxylase multiple interactions ISO scopolin binds to and affects the activity of UROD protein CTD PMID:23209648 NCBI chr 5:135,855,429...135,859,515
Ensembl chr 5:135,855,433...135,859,643
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      biological role 19732
        growth regulator 4987
          plant growth regulator 4950
            scopoletin 27
              guaiacylglycerol beta-scopoletinyl ether 0
              scopolin 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic molecule 19486
                              organic cyclic compound 19282
                                organic heterocyclic compound 18407
                                  oxacycle 17181
                                    benzopyran 10132
                                      1-benzopyran 9848
                                        chromenes 931
                                          chromenone 851
                                            coumarins 573
                                              hydroxycoumarin 300
                                                umbelliferone 80
                                                  scopoletin 27
                                                    guaiacylglycerol beta-scopoletinyl ether 0
                                                    scopolin 2
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.