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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:hydroxycoumarin
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Accession:CHEBI:37912 term browser browse the term
Definition:Any coumarin carrying at least one hydroxy substituent.
Synonyms:related_synonym: hydroxycoumarins
 alt_id: CHEBI:24691;   CHEBI:24692


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4-hydroxy-3-(2-hydroxy-3-oxo-1-phenylbutyl)-2H-chromen-2-one term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
affects chemical synthesis		 ISO [10-hydroxywarfarin binds to and results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA
CYP3A4 protein affects the chemical synthesis of 10-hydroxywarfarin		 CTD PMID:16035367 PMID:20735727 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO 10-hydroxywarfarin binds to and results in increased activity of NR1I2 protein; [10-hydroxywarfarin binds to and results in increased activity of NR1I2 protein] which results in increased expression of CYP2C9 mRNA; [10-hydroxywarfarin binds to and results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA CTD PMID:20735727 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 multiple interactions ISO 10-hydroxywarfarin binds to and results in decreased activity of UGT2B7 protein; 10-hydroxywarfarin inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Zidovudine]; [10-hydroxywarfarin binds to and results in decreased activity of UGT2B7 protein] which results in decreased glucuronidation of Zidovudine CTD PMID:25393417 NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604 		JBrowse link
4-hydroxy-3-[1-(4-hydroxyphenyl)-3-oxobutyl]-2H-chromen-2-one term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO [4'-hydroxywarfarin binds to and results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA CTD PMID:20735727 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO 4'-hydroxywarfarin binds to and results in increased activity of NR1I2 protein; [4'-hydroxywarfarin binds to and results in increased activity of NR1I2 protein] which results in increased expression of CYP2C9 mRNA; [4'-hydroxywarfarin binds to and results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA CTD PMID:20735727 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 multiple interactions ISO 4'-hydroxywarfarin binds to and results in decreased activity of UGT2B7 protein; 4'-hydroxywarfarin inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Zidovudine]; [4'-hydroxywarfarin binds to and results in decreased activity of UGT2B7 protein] which results in decreased glucuronidation of Zidovudine CTD PMID:25393417 NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604 		JBrowse link
4-hydroxycoumarin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrm1 ADRM1 26S proteasome ubiquitin receptor decreases expression ISO 4-hydroxycoumarin results in decreased expression of ADRM1 mRNA CTD PMID:18492274 NCBI chr 3:167,265,435...167,270,197
Ensembl chr 3:167,265,296...167,270,195 		JBrowse link
G Glo1 glyoxalase 1 decreases activity ISO 4-hydroxycoumarin analog results in decreased activity of GLO1 protein CTD PMID:33989593 NCBI chr20:8,663,617...8,681,661
Ensembl chr20:8,662,801...8,681,649 		JBrowse link
G Ptk2 protein tyrosine kinase 2 decreases phosphorylation ISO 4-hydroxycoumarin results in decreased phosphorylation of PTK2 protein CTD PMID:18492274 NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783 		JBrowse link
G Pxn paxillin decreases expression
decreases phosphorylation
affects localization		 ISO 4-hydroxycoumarin results in decreased expression of PXN mRNA alternative form; 4-hydroxycoumarin results in decreased expression of PXN protein alternative form
4-hydroxycoumarin results in decreased phosphorylation of PXN protein
4-hydroxycoumarin affects the localization of PXN protein		 CTD PMID:18492274 NCBI chr12:41,060,791...41,107,952
Ensembl chr12:41,060,791...41,107,931 		JBrowse link
G Rac1 Rac family small GTPase 1 decreases expression ISO 4-hydroxycoumarin results in decreased expression of RAC1 protein CTD PMID:18492274 NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251 		JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 increases metabolic processing
affects metabolic processing		 EXP UGT1A6 protein results in increased metabolism of 4-hydroxycoumarin
UGT1A6 gene polymorphism affects the metabolism of 4-hydroxycoumarin		 CTD PMID:9429234 NCBI chr 9:88,747,213...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Vkorc1 vitamin K epoxide reductase complex, subunit 1 decreases activity
multiple interactions		 ISO 4-hydroxycoumarin results in decreased activity of VKORC1 protein
4-hydroxycoumarin inhibits the reaction [VKORC1 protein results in increased reduction of Vitamin K 1]		 CTD PMID:29581108 NCBI chr 1:182,502,491...182,505,012
Ensembl chr 1:182,500,844...182,505,008 		JBrowse link
G Vkorc1l1 vitamin K epoxide reductase complex, subunit 1-like 1 multiple interactions
decreases activity		 ISO 4-hydroxycoumarin inhibits the reaction [VKORC1L1 protein results in increased reduction of Vitamin K 1]
4-hydroxycoumarin results in decreased activity of VKORC1L1 protein		 CTD PMID:29581108 NCBI chr12:26,717,959...26,768,193
Ensembl chr12:26,623,976...26,768,225 		JBrowse link
4-methylumbelliferone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg2 ATP binding cassette subfamily G member 2 affects export ISO ABCG2 protein affects the export of Hymecromone analog CTD PMID:15598971 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions ISO Hymecromone inhibits the reaction [Dietary Fats results in decreased expression of ADIPOQ protein] CTD PMID:24661945 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G Cat catalase multiple interactions ISO Hymecromone inhibits the reaction [Dietary Fats results in decreased activity of CAT protein] CTD PMID:24661945 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO Hymecromone inhibits the reaction [Dietary Fats results in increased activity of CYP2E1 protein] CTD PMID:24661945 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 increases sulfation ISO
EXP		 SULT1A1 protein results in increased sulfation of Hymecromone CTD PMID:11181495 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562 		JBrowse link
G Tp53 tumor protein p53 affects activity ISO Hymecromone affects the activity of TP53 protein; Hymecromone metabolite affects the activity of TP53 protein CTD PMID:35435491 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 multiple interactions
increases metabolic processing
increases activity
increases glucuronidation		 ISO [UGT1A1 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; [UGT1A1 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; belinostat inhibits the reaction [[UGT1A1 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; belinostat inhibits the reaction [UGT1A1 protein results in increased glucuronidation of Hymecromone]; Diclofenac inhibits the reaction [[UGT1A1 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; Diclofenac inhibits the reaction [UGT1A1 protein results in increased glucuronidation of Hymecromone]; Estradiol promotes the reaction [UGT1A1 protein results in increased glucuronidation of Hymecromone]; licochalcone A inhibits the reaction [Hymecromone results in increased activity of UGT1A1 protein]; osimertinib inhibits the reaction [UGT1A1 protein results in increased glucuronidation of Hymecromone]; pterostilbene inhibits the reaction [[UGT1A1 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide] CTD PMID:15378558 PMID:15593333 PMID:15802387 PMID:26875642 PMID:31812603 More... NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases activity
increases metabolic processing
multiple interactions
increases glucuronidation		 ISO Hymecromone results in increased activity of UGT1A3 protein
UGT1A3 protein results in increased metabolism of Hymecromone
[UGT1A3 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; [UGT1A3 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; Androsterone inhibits the reaction [[UGT1A3 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; Androsterone inhibits the reaction [UGT1A3 protein results in increased glucuronidation of Hymecromone]; belinostat inhibits the reaction [[UGT1A3 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; belinostat inhibits the reaction [UGT1A3 protein results in increased glucuronidation of Hymecromone]; licochalcone A inhibits the reaction [Hymecromone results in increased activity of UGT1A3 protein]; pterostilbene inhibits the reaction [[UGT1A3 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]		 CTD PMID:15802387 PMID:26875642 PMID:31812603 PMID:33290829 NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 affects metabolic processing
increases activity
multiple interactions
increases metabolic processing
increases glucuronidation		 EXP
ISO		 UGT1A6 gene polymorphism affects the metabolism of Hymecromone
Hymecromone results in increased activity of UGT1A6 protein
[UGT1A6 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; [UGT1A6 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; belinostat inhibits the reaction [[UGT1A6 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; belinostat inhibits the reaction [UGT1A6 protein results in increased glucuronidation of Hymecromone]; bisphenol A inhibits the reaction [UGT1A6 protein results in increased glucuronidation of Hymecromone]; Diclofenac inhibits the reaction [[UGT1A6 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; Diclofenac inhibits the reaction [UGT1A6 protein results in increased glucuronidation of Hymecromone]; licochalcone A inhibits the reaction [Hymecromone results in increased activity of UGT1A6 protein]; pterostilbene inhibits the reaction [[UGT1A6 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]		 CTD PMID:9429234 PMID:15802387 PMID:18214896 PMID:25393417 PMID:26875642 More... NCBI chr 9:88,747,213...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a7c UDP glucuronosyltransferase 1 family, polypeptide A7C increases glucuronidation EXP UGT1A7 protein results in increased glucuronidation of Hymecromone CTD PMID:15502008 NCBI chr 9:88,739,577...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a8 UDP glucuronosyltransferase family 1 member A8 increases glucuronidation EXP UGT1A8 protein results in increased glucuronidation of Hymecromone CTD PMID:15502008 NCBI chr 9:88,727,094...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation
increases metabolic processing
increases activity
multiple interactions		 ISO UGT1A9 protein results in increased glucuronidation of Hymecromone
UGT1A9 protein results in increased metabolism of Hymecromone
Hymecromone results in increased activity of UGT1A9 protein
[UGT1A9 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; [UGT1A9 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; Diclofenac inhibits the reaction [[UGT1A9 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; Diclofenac inhibits the reaction [UGT1A9 protein results in increased glucuronidation of Hymecromone]; licochalcone A inhibits the reaction [Hymecromone results in increased activity of UGT1A9 protein]; pterostilbene inhibits the reaction [[UGT1A9 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]		 CTD PMID:15378558 PMID:15802387 PMID:26875642 PMID:31812603 PMID:33290829 NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt2a1 UDP glucuronosyltransferase family 2 member A1 increases glucuronidation ISO UGT2A1 protein results in increased glucuronidation of Hymecromone CTD PMID:21164388 NCBI chr14:20,521,018...20,545,934
Ensembl chr14:20,517,951...20,545,531 		JBrowse link
G Ugt2b1 UDP glucuronosyltransferase 2 family, polypeptide B1 increases glucuronidation
increases activity
increases metabolic processing
multiple interactions		 EXP
ISO		 UGT2B1 protein results in increased glucuronidation of Hymecromone
UGT2B17 protein results in increased glucuronidation of Hymecromone
Hymecromone results in increased activity of UGT2B17 protein
UGT2B17 protein results in increased metabolism of Hymecromone
[UGT2B17 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; licochalcone A inhibits the reaction [Hymecromone results in increased activity of UGT2B17 protein]		 CTD PMID:8302279 PMID:8798464 PMID:26875642 PMID:33290829 NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986 		JBrowse link
G Ugt2b15 UDP glucuronosyltransferase family 2 member B15 increases metabolic processing EXP UGT2B15 protein results in increased metabolism of Hymecromone CTD PMID:7574722 NCBI chr14:20,768,015...20,783,599
Ensembl chr14:20,768,015...20,783,589 		JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 increases activity
increases glucuronidation
increases metabolic processing
multiple interactions		 ISO Hymecromone results in increased activity of UGT2B7 protein
UGT2B7 protein results in increased glucuronidation of Hymecromone
UGT2B7 protein results in increased metabolism of Hymecromone
[UGT2B7 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; [UGT2B7 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; Androsterone inhibits the reaction [[UGT2B7 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; Androsterone inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Hymecromone]; belinostat inhibits the reaction [[UGT2B7 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; belinostat inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Hymecromone]; licochalcone A inhibits the reaction [Hymecromone results in increased activity of UGT2B7 protein]; pterostilbene inhibits the reaction [[UGT2B7 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]		 CTD PMID:26875642 PMID:31812603 PMID:33290829 NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604 		JBrowse link
4-methylumbelliferone beta-D-glucuronide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 multiple interactions ISO [UGT1A1 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; [UGT1A1 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; belinostat inhibits the reaction [[UGT1A1 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; Diclofenac inhibits the reaction [[UGT1A1 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; pterostilbene inhibits the reaction [[UGT1A1 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide] CTD PMID:31812603 PMID:33290829 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 multiple interactions ISO [UGT1A3 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; [UGT1A3 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; Androsterone inhibits the reaction [[UGT1A3 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; belinostat inhibits the reaction [[UGT1A3 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; pterostilbene inhibits the reaction [[UGT1A3 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide] CTD PMID:31812603 PMID:33290829 NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 multiple interactions ISO [UGT1A6 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; [UGT1A6 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; belinostat inhibits the reaction [[UGT1A6 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; Diclofenac inhibits the reaction [[UGT1A6 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; pterostilbene inhibits the reaction [[UGT1A6 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide] CTD PMID:31812603 PMID:33290829 NCBI chr 9:88,747,213...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 multiple interactions ISO [UGT1A9 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; [UGT1A9 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; Diclofenac inhibits the reaction [[UGT1A9 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; pterostilbene inhibits the reaction [[UGT1A9 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide] CTD PMID:31812603 PMID:33290829 NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt2b1 UDP glucuronosyltransferase 2 family, polypeptide B1 multiple interactions ISO [UGT2B17 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide CTD PMID:33290829 NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986 		JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 multiple interactions ISO [UGT2B7 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; [UGT2B7 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; Androsterone inhibits the reaction [[UGT2B7 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; belinostat inhibits the reaction [[UGT2B7 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; pterostilbene inhibits the reaction [[UGT2B7 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide] CTD PMID:31812603 PMID:33290829 NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604 		JBrowse link
4-methylumbelliferone sulfate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc22a19 solute carrier family 22, member 19 multiple interactions EXP 4-methylumbelliferyl sulfate inhibits the reaction [SLC22A19 protein affects the transport of estrone sulfate] CTD PMID:16079298 NCBI chr 1:204,910,450...204,965,538
Ensembl chr 1:204,910,455...204,965,538 		JBrowse link
G Slc22a25 solute carrier family 22, member 25 multiple interactions EXP 4-methylumbelliferyl sulfate inhibits the reaction [SLC22A9 protein affects the transport of estrone sulfate] CTD PMID:18441515 NCBI chr 1:205,338,698...205,498,486
Ensembl chr 1:205,338,699...205,433,085 		JBrowse link
4-methylumbelliferyl acetate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Calr calreticulin increases activity ISO 4-methylumbelliferyl acetate results in increased activity of CALR protein CTD PMID:20188080 NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414 		JBrowse link
G Ces1d carboxylesterase 1D multiple interactions
increases hydrolysis		 ISO Atropine inhibits the reaction [CES1 protein results in increased hydrolysis of 4-methylumbelliferyl acetate]; Cocaine inhibits the reaction [CES1 protein results in increased hydrolysis of 4-methylumbelliferyl acetate]; tropacocaine inhibits the reaction [CES1 protein results in increased hydrolysis of 4-methylumbelliferyl acetate] CTD PMID:9311626 NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035 		JBrowse link
G Ces2h carboxylesterase 2H increases hydrolysis ISO CES2 protein results in increased hydrolysis of 4-methylumbelliferyl acetate CTD PMID:9169443 NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830 		JBrowse link
G Txn1 thioredoxin 1 increases activity ISO 4-methylumbelliferyl acetate results in increased activity of TXN protein CTD PMID:24103856 NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629 		JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO 4-methylumbelliferyl acetate results in increased expression of VEGFA protein CTD PMID:24103856 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
4-methylumbelliferyl beta-D-galactoside term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Car12 carbonic anhydrase 12 decreases activity ISO 4-methylumbelliferyl-galactopyranoside analog results in decreased activity of CA12 protein CTD PMID:22077347 NCBI chr 8:67,274,739...67,330,428
Ensembl chr 8:67,274,359...67,330,440 		JBrowse link
G Car9 carbonic anhydrase 9 decreases activity ISO 4-methylumbelliferyl-galactopyranoside analog results in decreased activity of CA9 protein CTD PMID:22077347 NCBI chr 5:57,763,234...57,769,838
Ensembl chr 5:57,763,206...57,769,838 		JBrowse link
4-methylumbelliferyl beta-D-glucoside term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gaa alpha glucosidase multiple interactions
increases metabolic processing		 ISO GAA gene SNP inhibits the reaction [GAA protein results in increased metabolism of 4-methylumbelliferyl glucoside] CTD PMID:21963784 NCBI chr10:104,529,673...104,546,836
Ensembl chr10:104,529,747...104,546,836 		JBrowse link
7,8-diacetoxy-4-methylcoumarin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2l1 Bcl2-like 1 decreases expression ISO 7,8-diacetoxy-4-methylcoumarin results in decreased expression of BCL2L1 protein CTD PMID:19061872 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Calr calreticulin increases activity
multiple interactions		 ISO 7,8-diacetoxy-4-methylcoumarin results in increased activity of CALR protein
7,8-diacetoxy-4-methylcoumarin promotes the reaction [CALR protein results in increased acetylation of NOS1 protein]		 CTD PMID:20188080 PMID:24103856 NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414 		JBrowse link
G Casp3 caspase 3 increases activity ISO 7,8-diacetoxy-4-methylcoumarin results in increased activity of CASP3 protein CTD PMID:19061872 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 increases activity ISO 7,8-diacetoxy-4-methylcoumarin results in increased activity of CASP9 protein CTD PMID:19061872 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cycs cytochrome c, somatic affects localization ISO 7,8-diacetoxy-4-methylcoumarin affects the localization of CYCS protein CTD PMID:19061872 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054 		JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions ISO 7,8-diacetoxy-4-methylcoumarin promotes the reaction [CALR protein results in increased acetylation of NOS1 protein] CTD PMID:24103856 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945 		JBrowse link
G Nos2 nitric oxide synthase 2 increases expression ISO 7,8-diacetoxy-4-methylcoumarin results in increased expression of NOS2 CTD PMID:24103856 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nos3 nitric oxide synthase 3 increases expression ISO 7,8-diacetoxy-4-methylcoumarin results in increased expression of NOS3 CTD PMID:24103856 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO 7,8-diacetoxy-4-methylcoumarin results in decreased expression of PTGS2 protein CTD PMID:19061872 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rac1 Rac family small GTPase 1 decreases expression ISO DAMTC decreases expression of RAC1 protein in non-small cell lung cancer cells RGD PMID:23059821 RGD:155791641 NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO 7,8-diacetoxy-4-methylcoumarin inhibits the reaction [TNF protein affects the localization of RELA protein] CTD PMID:19061872 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO 7,8-diacetoxy-4-methylcoumarin inhibits the reaction [TNF protein affects the localization of RELA protein] CTD PMID:19061872 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 increases expression ISO 7,8-diacetoxy-4-methylcoumarin results in increased expression of TP53 protein CTD PMID:19061872 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Txn1 thioredoxin 1 increases activity
increases expression		 ISO 7,8-diacetoxy-4-methylcoumarin results in increased activity of TXN protein
7,8-diacetoxy-4-methylcoumarin results in increased expression of TXN mRNA		 CTD PMID:24103856 NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629 		JBrowse link
G Txnip thioredoxin interacting protein decreases expression ISO 7,8-diacetoxy-4-methylcoumarin results in decreased expression of TXNIP mRNA CTD PMID:24103856 NCBI chr 2:184,093,079...184,096,882
Ensembl chr 2:184,092,991...184,096,886 		JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO 7,8-diacetoxy-4-methylcoumarin results in increased expression of TXNRD1 mRNA CTD PMID:24103856 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863 		JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO 7,8-diacetoxy-4-methylcoumarin results in increased expression of VEGFA mRNA; 7,8-diacetoxy-4-methylcoumarin results in increased expression of VEGFA protein CTD PMID:24103856 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
7,8-dihydroxycoumarin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin multiple interactions EXP daphnetin inhibits the reaction [Benzene results in decreased expression of ALB protein] CTD PMID:33749080 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [daphnetin inhibits the reaction [Lipopolysaccharides results in increased expression of BAX protein]]; daphnetin inhibits the reaction [Lipopolysaccharides results in increased expression of BAX protein]; daphnetin inhibits the reaction [sodium arsenite results in increased expression of BAX protein]; REG3A protein inhibits the reaction [daphnetin inhibits the reaction [Lipopolysaccharides results in increased expression of BAX protein]]
daphnetin inhibits the reaction [Dextran Sulfate results in increased expression of BAX protein]		 CTD PMID:30738023 PMID:37209277 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide promotes the reaction [daphnetin inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]]; daphnetin inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]; daphnetin inhibits the reaction [sodium arsenite results in decreased expression of BCL2 protein]; REG3A protein inhibits the reaction [daphnetin inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]]
daphnetin inhibits the reaction [Dextran Sulfate results in decreased expression of BCL2 protein]		 CTD PMID:30738023 PMID:37209277 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO daphnetin inhibits the reaction [Dextran Sulfate results in increased cleavage of CASP3 protein]
alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide promotes the reaction [daphnetin inhibits the reaction [Lipopolysaccharides results in increased cleavage of CASP3 protein]]; daphnetin inhibits the reaction [Lipopolysaccharides results in increased cleavage of CASP3 protein]; REG3A protein inhibits the reaction [daphnetin inhibits the reaction [Lipopolysaccharides results in increased cleavage of CASP3 protein]]		 CTD PMID:37209277 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions EXP daphnetin inhibits the reaction [Benzene results in increased expression of CYP2E1 mRNA] CTD PMID:33749080 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO daphnetin results in increased expression of GCLC protein CTD PMID:30738023 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO daphnetin results in increased expression of GCLM protein CTD PMID:30738023 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP daphnetin inhibits the reaction [Benzene results in increased expression of GPT protein] CTD PMID:33749080 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions		 ISO daphnetin results in increased expression of HMOX1 protein
[sodium arsenite co-treated with daphnetin] results in increased expression of HMOX1 protein; NFE2L2 protein affects the reaction [daphnetin results in increased expression of HMOX1 protein]		 CTD PMID:30738023 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP
ISO		 daphnetin inhibits the reaction [Benzene results in increased expression of IL1B protein]
daphnetin inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein]
alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide promotes the reaction [daphnetin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]]; daphnetin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]; REG3A protein inhibits the reaction [daphnetin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]]		 CTD PMID:33749080 PMID:37209277 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il2 interleukin 2 multiple interactions EXP daphnetin inhibits the reaction [Benzene results in increased expression of IL2 protein] CTD PMID:33749080 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP
ISO		 daphnetin inhibits the reaction [Benzene results in increased expression of IL6 protein]
daphnetin inhibits the reaction [Dextran Sulfate results in increased expression of IL6 protein]
alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide promotes the reaction [daphnetin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]]; daphnetin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; REG3A protein inhibits the reaction [daphnetin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]]		 CTD PMID:33749080 PMID:37209277 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Jak2 Janus kinase 2 multiple interactions ISO alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide promotes the reaction [daphnetin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of JAK2 protein]]; daphnetin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of JAK2 protein]; REG3A protein inhibits the reaction [daphnetin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of JAK2 protein]] CTD PMID:37209277 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189 		JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 decreases expression ISO daphnetin results in decreased expression of KEAP1 protein CTD PMID:30738023 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO daphnetin results in increased phosphorylation of MAPK1 protein CTD PMID:30738023 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO daphnetin results in increased phosphorylation of MAPK3 protein CTD PMID:30738023 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO [sodium arsenite co-treated with daphnetin] results in increased expression of NFE2L2 protein; daphnetin results in increased expression of and affects the localization of NFE2L2 protein; NFE2L2 protein affects the reaction [daphnetin results in increased expression of HMOX1 protein] CTD PMID:30738023 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO daphnetin results in increased expression of NQO1 protein CTD PMID:30738023 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Ocln occludin multiple interactions ISO daphnetin inhibits the reaction [Dextran Sulfate results in decreased expression of OCLN protein] CTD PMID:37209277 NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150 		JBrowse link
G Reg3b regenerating family member 3 beta multiple interactions ISO daphnetin inhibits the reaction [Lipopolysaccharides results in increased expression of REG3A protein]; REG3A protein inhibits the reaction [daphnetin inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]]; REG3A protein inhibits the reaction [daphnetin inhibits the reaction [Lipopolysaccharides results in increased cleavage of CASP3 protein]]; REG3A protein inhibits the reaction [daphnetin inhibits the reaction [Lipopolysaccharides results in increased expression of BAX protein]]; REG3A protein inhibits the reaction [daphnetin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of JAK2 protein]]; REG3A protein inhibits the reaction [daphnetin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT3 protein]]; REG3A protein inhibits the reaction [daphnetin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]]; REG3A protein inhibits the reaction [daphnetin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]]; REG3A protein inhibits the reaction [daphnetin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]] CTD PMID:37209277 NCBI chr 4:110,861,775...110,865,015
Ensembl chr 4:110,861,775...110,865,015 		JBrowse link
G S1pr1 sphingosine-1-phosphate receptor 1 multiple interactions EXP daphnetin inhibits the reaction [Benzene results in increased expression of S1PR1 mRNA] CTD PMID:33749080 NCBI chr 2:203,624,752...203,629,110
Ensembl chr 2:203,621,587...203,629,681 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide promotes the reaction [daphnetin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT3 protein]]; daphnetin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT3 protein]; REG3A protein inhibits the reaction [daphnetin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT3 protein]] CTD PMID:37209277 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Tjp1 tight junction protein 1 multiple interactions ISO daphnetin inhibits the reaction [Dextran Sulfate results in decreased expression of TJP1 protein] CTD PMID:37209277 NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP
ISO		 daphnetin inhibits the reaction [Benzene results in increased expression of TNF protein]
daphnetin inhibits the reaction [Dextran Sulfate results in increased expression of TNF protein]
alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide promotes the reaction [daphnetin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; daphnetin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; REG3A protein inhibits the reaction [daphnetin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]		 CTD PMID:33749080 PMID:37209277 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
7-ethoxycoumarin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases metabolic processing ISO CYP2E1 protein results in increased metabolism of 7-ethoxycoumarin CTD PMID:18385292 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
7-hydroxycoumarin O(7)-glucosiduronic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ugt2b15 UDP glucuronosyltransferase family 2 member B15 increases abundance EXP UGT2B15 protein results in increased abundance of 7-hydroxycoumarin glucuronide CTD PMID:7574722 NCBI chr14:20,768,015...20,783,599
Ensembl chr14:20,768,015...20,783,589 		JBrowse link
7-Hydroxywarfarin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 multiple interactions ISO 7-hydroxywarfarin binds to and results in decreased activity of UGT2B7 protein; 7-hydroxywarfarin inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Zidovudine]; [7-hydroxywarfarin binds to and results in decreased activity of UGT2B7 protein] which results in decreased glucuronidation of Zidovudine CTD PMID:25393417 NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604 		JBrowse link
G Vkorc1 vitamin K epoxide reductase complex, subunit 1 affects abundance ISO VKORC1 gene polymorphism affects the abundance of 7-hydroxywarfarin CTD PMID:25986145 NCBI chr 1:182,502,491...182,505,012
Ensembl chr 1:182,500,844...182,505,008 		JBrowse link
acenocoumarol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A affects response to substance ISO ABCB1 gene polymorphism affects the susceptibility to Acenocoumarol CTD PMID:18021343 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Apoe apolipoprotein E affects response to substance ISO APOE gene polymorphism affects the susceptibility to Acenocoumarol CTD PMID:15861030 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 affects metabolic processing ISO CYP1A1 protein affects the metabolism of Acenocoumarol CTD PMID:11918509 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 affects metabolic processing ISO CYP1A2 protein affects the metabolism of Acenocoumarol CTD PMID:11918509 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 affects response to substance ISO CYP2C18 gene polymorphism affects the susceptibility to Acenocoumarol CTD PMID:19578179 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066 		JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 affects metabolic processing ISO CYP2C19 protein affects the metabolism of Acenocoumarol CTD PMID:11918509 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G F10 coagulation factor X decreases activity EXP Acenocoumarol results in decreased activity of F10 protein CTD PMID:3490277 NCBI chr16:76,468,834...76,488,141
Ensembl chr16:76,468,838...76,488,141 		JBrowse link
G F2 coagulation factor II, thrombin decreases activity EXP Acenocoumarol results in decreased activity of F2 protein CTD PMID:3490277 NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486 		JBrowse link
G F5 coagulation factor V decreases activity EXP Acenocoumarol results in decreased activity of F5 protein CTD PMID:3490277 NCBI chr13:76,513,509...76,583,106
Ensembl chr13:76,513,255...76,582,317 		JBrowse link
G F7 coagulation factor VII decreases activity EXP Acenocoumarol results in decreased activity of F7 protein CTD PMID:3490277 NCBI chr16:76,489,775...76,500,636
Ensembl chr16:76,489,717...76,500,610 		JBrowse link
G F9 coagulation factor IX decreases activity EXP Acenocoumarol results in decreased activity of F9 protein CTD PMID:3490277 NCBI chr  X:138,352,334...138,396,835
Ensembl chr  X:138,352,298...138,396,835 		JBrowse link
G Ggcx gamma-glutamyl carboxylase increases activity EXP Acenocoumarol results in increased activity of GGCX protein CTD PMID:3490277 NCBI chr 4:104,469,737...104,485,631
Ensembl chr 4:104,469,765...104,487,063 		JBrowse link
G Vkorc1 vitamin K epoxide reductase complex, subunit 1 decreases response to substance
decreases activity
multiple interactions
affects response to substance
increases response to substance		 ISO VKORC1 promoter polymorphism results in decreased susceptibility to Acenocoumarol; VKORC1 protein polymorphism results in decreased susceptibility to Acenocoumarol
Acenocoumarol results in decreased activity of VKORC1 protein
Acenocoumarol inhibits the reaction [VKORC1 protein results in increased reduction of Vitamin K 1]
VKORC1 gene polymorphism affects the susceptibility to Acenocoumarol; VKORC1 gene SNP affects the susceptibility to Acenocoumarol; VKORC1 intron SNP affects the susceptibility to Acenocoumarol; VKORC1 polymorphism affects the susceptibility to Acenocoumarol; VKORC1 protein polymorphism affects the susceptibility to Acenocoumarol
VKORC1 protein results in increased susceptibility to Acenocoumarol		 CTD PMID:16201835 PMID:16611310 PMID:16869821 PMID:17036862 PMID:18698879 More... NCBI chr 1:182,502,491...182,505,012
Ensembl chr 1:182,500,844...182,505,008 		JBrowse link
G Vkorc1l1 vitamin K epoxide reductase complex, subunit 1-like 1 multiple interactions
decreases activity		 ISO Acenocoumarol inhibits the reaction [VKORC1L1 protein results in increased reduction of Vitamin K 1]
Acenocoumarol results in decreased activity of VKORC1L1 protein		 CTD PMID:29581108 NCBI chr12:26,717,959...26,768,193
Ensembl chr12:26,623,976...26,768,225 		JBrowse link
auraptene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO aurapten promotes the reaction [ABCB1 protein results in increased hydrolysis of Adenosine Triphosphate]; aurapten promotes the reaction [ABCB1 protein results in increased import of Daunorubicin] CTD PMID:18955043 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Ccna2 cyclin A2 affects expression ISO aurapten affects the expression of CCNA2 mRNA CTD PMID:23320178 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577 		JBrowse link
G Ccnb2 cyclin B2 affects expression ISO aurapten affects the expression of CCNB2 mRNA CTD PMID:23320178 NCBI chr 8:71,087,594...71,100,794
Ensembl chr 8:71,087,595...71,100,874 		JBrowse link
G Cdc45 cell division cycle 45 affects expression ISO aurapten affects the expression of CDC45 mRNA CTD PMID:23320178 NCBI chr11:82,185,427...82,210,630
Ensembl chr11:82,185,473...82,210,619 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 affects expression ISO aurapten affects the expression of CDK1 mRNA CTD PMID:23320178 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408 		JBrowse link
G Cdkn2b cyclin-dependent kinase inhibitor 2B affects expression ISO aurapten affects the expression of CDKN2B mRNA CTD PMID:23320178 NCBI chr 5:104,009,839...104,019,082
Ensembl chr 5:104,010,680...104,019,050 		JBrowse link
G Cdkn2c cyclin-dependent kinase inhibitor 2C affects expression ISO aurapten affects the expression of CDKN2C mRNA CTD PMID:23320178 NCBI chr 5:124,411,123...124,416,278
Ensembl chr 5:124,411,124...124,416,278 		JBrowse link
G Chek1 checkpoint kinase 1 affects expression ISO aurapten affects the expression of CHEK1 mRNA CTD PMID:23320178 NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009 		JBrowse link
G Chek2 checkpoint kinase 2 affects expression ISO aurapten affects the expression of CHEK2 mRNA CTD PMID:23320178 NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286 		JBrowse link
G Ctnnb1 catenin beta 1 decreases expression EXP aurapten results in decreased expression of CTNNB1 protein mutant form CTD PMID:16012713 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO aurapten inhibits the reaction [DDT results in increased expression of CYP1A1 mRNA]; aurapten inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] CTD PMID:20865247 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 affects expression ISO aurapten affects the expression of DDIT3 mRNA CTD PMID:23320178 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Dusp1 dual specificity phosphatase 1 affects expression ISO aurapten affects the expression of DUSP1 mRNA CTD PMID:23320178 NCBI chr10:16,680,478...16,683,275 JBrowse link
G E2f1 E2F transcription factor 1 affects expression ISO aurapten affects the expression of E2F1 mRNA CTD PMID:23320178 NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361 		JBrowse link
G E2f2 E2F transcription factor 2 affects expression ISO aurapten affects the expression of E2F2 mRNA CTD PMID:23320178 NCBI chr 5:148,399,193...148,422,595
Ensembl chr 5:148,399,642...148,421,217 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha affects expression ISO aurapten affects the expression of GADD45A mRNA CTD PMID:23320178 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit affects expression ISO aurapten affects the expression of JUN mRNA CTD PMID:23320178 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Kif20b kinesin family member 20B affects expression ISO aurapten affects the expression of KIF20B mRNA CTD PMID:23320178 NCBI chr 1:232,428,293...232,483,798
Ensembl chr 1:232,428,371...232,483,787 		JBrowse link
G Mcm3 minichromosome maintenance complex component 3 affects expression ISO aurapten affects the expression of MCM3 mRNA CTD PMID:23320178 NCBI chr 9:23,219,169...23,237,314
Ensembl chr 9:23,219,169...23,237,314 		JBrowse link
G Mcm6 minichromosome maintenance complex component 6 affects expression ISO aurapten affects the expression of MCM6 mRNA CTD PMID:23320178 NCBI chr13:39,826,745...39,851,937
Ensembl chr13:39,826,763...39,851,960 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 affects response to substance ISO NFE2L2 protein affects the susceptibility to aurapten CTD PMID:19150646 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO aurapten inhibits the reaction [DDT results in increased expression of PTGS2 mRNA]; aurapten inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PTGS2 mRNA] CTD PMID:20865247 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Uhrf1 ubiquitin-like with PHD and ring finger domains 1 affects expression ISO aurapten affects the expression of UHRF1 mRNA CTD PMID:23320178 NCBI chr 9:1,133,117...1,154,639
Ensembl chr 9:1,134,909...1,154,631 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO aurapten inhibits the reaction [DDT results in increased expression of VEGFA mRNA]; aurapten inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of VEGFA mRNA] CTD PMID:20865247 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
Coumachlor term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Vkorc1 vitamin K epoxide reductase complex, subunit 1 multiple interactions
decreases activity		 ISO coumachlor inhibits the reaction [VKORC1 protein results in increased reduction of Vitamin K 1]; coumachlor inhibits the reaction [VKORC1 protein results in increased reduction of vitamin K1 oxide]
coumachlor results in decreased activity of VKORC1 protein		 CTD PMID:29581108 NCBI chr 1:182,502,491...182,505,012
Ensembl chr 1:182,500,844...182,505,008 		JBrowse link
G Vkorc1l1 vitamin K epoxide reductase complex, subunit 1-like 1 decreases activity
multiple interactions		 ISO coumachlor results in decreased activity of VKORC1L1 protein
coumachlor inhibits the reaction [VKORC1L1 protein results in increased reduction of Vitamin K 1]; coumachlor inhibits the reaction [VKORC1L1 protein results in increased reduction of vitamin K1 oxide]		 CTD PMID:29581108 NCBI chr12:26,717,959...26,768,193
Ensembl chr12:26,623,976...26,768,225 		JBrowse link
coumaphos term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity ISO Coumaphos metabolite results in decreased activity of ACHE protein; Coumaphos results in decreased activity of ACHE protein CTD PMID:30625376 PMID:33844597 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Ar androgen receptor multiple interactions ISO Coumaphos inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein] CTD PMID:33049310 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Coumaphos binds to and results in increased activity of ESR1 protein CTD PMID:33049310 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO Coumaphos binds to and results in increased activity of ESR2 protein CTD PMID:33049310 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Gpat3 glycerol-3-phosphate acyltransferase 3 increases expression ISO Coumaphos results in increased expression of GPAT3 mRNA CTD PMID:26198647 NCBI chr14:8,715,367...8,768,051
Ensembl chr14:8,714,373...8,766,490 		JBrowse link
G Lif LIF, interleukin 6 family cytokine increases expression ISO Coumaphos results in increased expression of LIF mRNA CTD PMID:26198647 NCBI chr14:79,131,049...79,140,486
Ensembl chr14:79,134,574...79,140,482 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO Coumaphos binds to and results in increased activity of NR1I2 protein CTD PMID:33049310 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO Coumaphos binds to and results in increased activity of PPARG protein CTD PMID:33049310 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Rara retinoic acid receptor, alpha increases activity ISO Coumaphos results in increased activity of RARA protein CTD PMID:20143881 NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO Coumaphos results in increased expression of SLC7A11 mRNA CTD PMID:26198647 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536 		JBrowse link
G Thrb thyroid hormone receptor beta multiple interactions ISO Coumaphos binds to and results in increased activity of THRB protein CTD PMID:33049310 NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916 		JBrowse link
G Tp53 tumor protein p53 affects activity ISO Coumaphos metabolite affects the activity of TP53 protein CTD PMID:35435491 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
Coumatetralyl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Vkorc1 vitamin K epoxide reductase complex, subunit 1 decreases response to substance
multiple interactions
decreases activity		 EXP
ISO		 VKORC1 protein polymorphism results in decreased susceptibility to coumatetralyl
coumatetralyl inhibits the reaction [VKORC1 protein results in increased reduction of Vitamin K 1]
coumatetralyl results in decreased activity of VKORC1 protein		 CTD PMID:27117082 PMID:29581108 NCBI chr 1:182,502,491...182,505,012
Ensembl chr 1:182,500,844...182,505,008 		JBrowse link
G Vkorc1l1 vitamin K epoxide reductase complex, subunit 1-like 1 multiple interactions
decreases activity		 ISO coumatetralyl inhibits the reaction [VKORC1L1 protein results in increased reduction of Vitamin K 1]
coumatetralyl results in decreased activity of VKORC1L1 protein		 CTD PMID:29581108 NCBI chr12:26,717,959...26,768,193
Ensembl chr12:26,623,976...26,768,225 		JBrowse link
dicoumarol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c1 aldo-keto reductase family 1, member C1 decreases activity EXP Dicumarol results in decreased activity of AKR1C6 protein CTD PMID:16788056 NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326 		JBrowse link
G Alb albumin affects binding ISO Dicumarol binds to ALB protein CTD PMID:62049 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Atm ATM serine/threonine kinase multiple interactions ISO Dicumarol inhibits the reaction [2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone analog results in increased expression of ATM protein modified form] CTD PMID:26630137 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP
ISO		 [aminochrome 1 co-treated with Dicumarol] results in increased activity of CASP3 protein; Dicumarol promotes the reaction [Doxorubicin results in increased activity of CASP3 protein]; Progesterone inhibits the reaction [Dicumarol promotes the reaction [Doxorubicin results in increased activity of CASP3 protein]]
Dicumarol inhibits the reaction [2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone analog results in decreased expression of CASP3 protein]		 CTD PMID:21427056 PMID:21947872 PMID:26630137 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cat catalase decreases response to substance
multiple interactions		 ISO
EXP		 CAT protein results in decreased susceptibility to Dicumarol
[Dopamine co-treated with Dicumarol] results in increased expression of CAT mRNA		 CTD PMID:11299314 PMID:17040906 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cd86 CD86 molecule multiple interactions ISO [Dicumarol results in decreased activity of NQO1 protein] inhibits the reaction [Eugenol results in increased expression of CD86 protein] CTD PMID:21742781 NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO Dicumarol inhibits the reaction [diaziquone results in increased expression of CDKN1A mRNA]; Dicumarol inhibits the reaction [Nicotinamide Mononucleotide inhibits the reaction [Hydrogen Peroxide results in increased expression of CDKN1A protein]]; Dicumarol inhibits the reaction [RB1CC1 protein results in increased expression of CDKN1A protein] CTD PMID:9343371 PMID:16061648 PMID:37640247 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A multiple interactions ISO Dicumarol inhibits the reaction [Nicotinamide Mononucleotide inhibits the reaction [Hydrogen Peroxide results in increased expression of CDKN2A protein]] CTD PMID:37640247 NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149 		JBrowse link
G Cycs cytochrome c, somatic multiple interactions EXP [aminochrome 1 co-treated with Dicumarol] affects the localization of CYCS protein CTD PMID:21427056 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions EXP
ISO		 Dicumarol promotes the reaction [CYP2E1 protein results in increased reduction of tirapazamine]
Dicumarol inhibits the reaction [[CYP2E1 protein co-treated with Paraquat] results in increased expression of KLF6 protein]; Dicumarol inhibits the reaction [[CYP2E1 protein co-treated with Vitamin K 3] results in increased expression of KLF6 protein]		 CTD PMID:7710944 PMID:22486562 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Drd5 dopamine receptor D5 increases expression EXP Dicumarol results in increased expression of DRD5 mRNA CTD PMID:18522901 NCBI chr14:72,487,950...72,491,050
Ensembl chr14:72,489,347...72,490,774 		JBrowse link
G Fabp1 fatty acid binding protein 1 multiple interactions EXP Dicoumarol inhibits the reaction [3-(p-azidobenzyl)-4-hydroxycoumarin binds to Fabp1 protein] RGD PMID:1939124 RGD:1626448 NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788 		JBrowse link
G Gpr35 G protein-coupled receptor 35 multiple interactions ISO
EXP		 Dicumarol binds to and results in increased activity of GPR35 protein CTD PMID:20919992 NCBI chr 9:93,527,165...93,539,573
Ensembl chr 9:93,527,127...93,539,299 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions ISO Dicumarol inhibits the reaction [1-nitropyrene results in increased expression of HSPA5 protein] CTD PMID:19460413 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions ISO Dicumarol inhibits the reaction [IGF1 protein results in increased phosphorylation of JUN protein] CTD PMID:11278392 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Dicumarol inhibits the reaction [IL1B protein results in increased expression of TP53 protein] CTD PMID:17959154 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Dicumarol inhibits the reaction [IGF1 protein results in increased phosphorylation of JUN protein]; Dicumarol inhibits the reaction [TNF protein results in increased phosphorylation of JUN protein] CTD PMID:11278392 PMID:17669387 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Klf6 KLF transcription factor 6 multiple interactions ISO Dicumarol inhibits the reaction [[CYP2E1 protein co-treated with Paraquat] results in increased expression of KLF6 protein]; Dicumarol inhibits the reaction [[CYP2E1 protein co-treated with Vitamin K 3] results in increased expression of KLF6 protein] CTD PMID:22486562 NCBI chr17:64,539,456...64,548,451
Ensembl chr17:64,531,463...64,588,570 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Dicumarol inhibits the reaction [TNF protein results in increased phosphorylation of MAPK1 protein] CTD PMID:17669387 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk10 mitogen activated protein kinase 10 multiple interactions
decreases activity		 ISO Dicumarol inhibits the reaction [Anisomycin results in increased activity of MAPK10 protein]; Dicumarol inhibits the reaction [Sorbitol results in increased activity of MAPK10 protein]; Dicumarol inhibits the reaction [TRAF2 protein results in increased activity of MAPK10 protein]; NQO1 protein inhibits the reaction [Dicumarol results in decreased activity of MAPK10 protein] CTD PMID:10531305 NCBI chr14:6,497,662...6,790,109
Ensembl chr14:6,497,707...6,786,201 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Dicumarol inhibits the reaction [TNF protein results in increased phosphorylation of MAPK3 protein] CTD PMID:17669387 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO Dicumarol inhibits the reaction [Adenosine Diphosphate results in increased phosphorylation of MAPK8 protein]; Dicumarol inhibits the reaction [Arsenic Trioxide results in increased activity of MAPK8 protein] CTD PMID:14701702 PMID:24466103 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions ISO Dicumarol inhibits the reaction [Adenosine Diphosphate results in increased phosphorylation of MAPK9 protein] CTD PMID:24466103 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO Dicumarol inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of MMP9 protein]; Dicumarol inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]; hydroquinone inhibits the reaction [Dicumarol inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of MMP9 protein]] CTD PMID:17669387 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mt1 metallothionein 1 multiple interactions ISO Dicumarol inhibits the reaction [Cadmium Chloride results in increased expression of MT1 mRNA]; Dicumarol inhibits the reaction [zinc chloride results in increased expression of MT1 mRNA]; Dicumarol inhibits the reaction [Zinc Sulfate results in increased expression of MT1 mRNA] CTD PMID:11551972 PMID:15142038 NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
Ensembl chr17:10,826,032...10,827,049 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO Dicumarol inhibits the reaction [Lipopolysaccharides results in increased activity of NFKB1 protein]; Dicumarol inhibits the reaction [TNF protein results in increased activity of NFKB1 protein] CTD PMID:10531305 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions
decreases activity
decreases expression
affects response to substance		 ISO
EXP		 [aristolochic acid I co-treated with Dicumarol] results in increased expression of NQO1 protein; [Dicumarol results in decreased activity of NQO1 protein] inhibits the reaction [Eugenol results in increased expression of CD86 protein]; [Dicumarol results in decreased activity of NQO1 protein] which results in decreased susceptibility to Mitomycin; [Dicumarol results in decreased activity of NQO1 protein] which results in decreased susceptibility to Streptonigrin; aristolochic acid I inhibits the reaction [Dicumarol results in decreased activity of NQO1 protein]; Dicumarol inhibits the reaction [[arsenite results in increased expression of NQO1 protein] which results in increased susceptibility to Mitomycin]; Dicumarol inhibits the reaction [NQO1 protein results in decreased susceptibility to arsenite]; Dicumarol inhibits the reaction [NQO1 protein results in increased metabolism of Mitomycin]; Dicumarol inhibits the reaction [NQO1 protein results in increased reduction of 2,6-Dichloroindophenol]; Dicumarol inhibits the reaction [TP53 protein binds to NQO1 protein]; NQO1 protein inhibits the reaction [Dicumarol results in decreased activity of MAPK10 protein]
[Dicumarol results in decreased activity of NQO1 protein] which results in decreased activity of diaziquone; Dicumarol results in decreased activity of NQO1 protein
Dicumarol results in decreased expression of NQO1 protein
[Dicumarol results in decreased activity of NQO1 protein] which results in decreased reduction of Chromium; Dicumarol inhibits the reaction [Benzo(a)pyrene results in increased activity of NQO1 protein]; Dicumarol inhibits the reaction [NQO1 protein inhibits the reaction [Vitamin K 3 results in increased chemical synthesis of Hydrogen Peroxide]]; Dicumarol inhibits the reaction [Progesterone results in increased activity of NQO1 protein]; Dicumarol inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of NQO1 protein]
[Dicumarol results in decreased activity of NQO1 protein] which results in decreased abundance of aristolactam I; [Dicumarol results in decreased activity of NQO1 protein] which results in increased abundance of aristolochic acid I; [Dicumarol results in decreased activity of NQO1 protein] which results in increased abundance of aristolochic acid I metabolite
NQO1 protein affects the susceptibility to Dicumarol		 CTD PMID:1379126 PMID:1701346 PMID:2113030 PMID:8572925 PMID:10092053 More... NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Rb1 RB transcriptional corepressor 1 increases phosphorylation ISO Dicumarol results in increased phosphorylation of RB1 protein CTD PMID:15896341 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302 		JBrowse link
G Rb1cc1 RB1-inducible coiled-coil 1 multiple interactions ISO Dicumarol inhibits the reaction [RB1CC1 protein results in increased expression of CDKN1A protein]; Dicumarol inhibits the reaction [RB1CC1 protein results in increased expression of TP53 protein]; Dicumarol inhibits the reaction [RB1CC1 protein results in increased stability of TP53 protein] CTD PMID:16061648 NCBI chr 5:13,161,648...13,225,560
Ensembl chr 5:13,161,648...13,225,560 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Dicumarol inhibits the reaction [Lipopolysaccharides results in increased activity of RELA protein]; Dicumarol inhibits the reaction [TNF protein affects the localization of RELA protein]; Dicumarol inhibits the reaction [TNF protein results in increased activity of RELA protein] CTD PMID:10531305 PMID:17669387 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Slc30a1 solute carrier family 30 member 1 multiple interactions ISO Dicumarol inhibits the reaction [Cadmium Chloride results in increased expression of SLC30A1 mRNA]; Dicumarol inhibits the reaction [Zinc Sulfate results in increased expression of SLC30A1 mRNA] CTD PMID:15142038 NCBI chr13:103,491,037...103,494,910
Ensembl chr13:103,491,037...103,494,910 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions EXP [Dopamine co-treated with Dicumarol co-treated with Copper Sulfate] results in decreased expression of SOD1 mRNA CTD PMID:11299314 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sod2 superoxide dismutase 2 decreases response to substance
multiple interactions		 ISO
EXP		 SOD2 protein results in decreased susceptibility to Dicumarol
[Dopamine co-treated with Dicumarol co-treated with Copper Sulfate] results in decreased expression of SOD2 mRNA		 CTD PMID:11299314 PMID:17040906 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Dicumarol inhibits the reaction [TNF protein affects the localization of RELA protein]; Dicumarol inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]; Dicumarol inhibits the reaction [TNF protein results in increased activity of RELA protein]; Dicumarol inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of MMP9 protein]; Dicumarol inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]; Dicumarol inhibits the reaction [TNF protein results in increased phosphorylation of JUN protein]; Dicumarol inhibits the reaction [TNF protein results in increased phosphorylation of MAPK1 protein]; Dicumarol inhibits the reaction [TNF protein results in increased phosphorylation of MAPK3 protein]; hydroquinone inhibits the reaction [Dicumarol inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of MMP9 protein]] CTD PMID:10531305 PMID:17669387 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 multiple interactions
decreases expression
increases degradation		 ISO Dicumarol inhibits the reaction [2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone analog results in increased expression of TP53 protein modified form]; Dicumarol inhibits the reaction [2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone analog results in increased expression of TP53 protein]; Dicumarol inhibits the reaction [IL1B protein results in increased expression of TP53 protein]; Dicumarol inhibits the reaction [RB1CC1 protein results in increased expression of TP53 protein]; Dicumarol inhibits the reaction [RB1CC1 protein results in increased stability of TP53 protein]; Dicumarol inhibits the reaction [TP53 protein binds to NQO1 protein]
Dicumarol results in decreased expression of TP53 protein
Dicumarol results in increased degradation of TP53 protein		 CTD PMID:14634213 PMID:16061648 PMID:17959154 PMID:22692362 PMID:26630137 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Traf2 Tnf receptor-associated factor 2 multiple interactions ISO Dicumarol inhibits the reaction [TRAF2 protein results in increased activity of MAPK10 protein] CTD PMID:10531305 NCBI chr 3:8,341,950...8,366,609
Ensembl chr 3:8,341,951...8,366,538 		JBrowse link
G Vkorc1 vitamin K epoxide reductase complex, subunit 1 decreases activity
multiple interactions		 ISO Dicumarol results in decreased activity of VKORC1 protein
Dicumarol inhibits the reaction [VKORC1 protein results in increased reduction of Vitamin K 1]		 CTD PMID:29581108 NCBI chr 1:182,502,491...182,505,012
Ensembl chr 1:182,500,844...182,505,008 		JBrowse link
G Vkorc1l1 vitamin K epoxide reductase complex, subunit 1-like 1 multiple interactions
decreases activity		 ISO Dicumarol inhibits the reaction [VKORC1L1 protein results in increased reduction of Vitamin K 1]
Dicumarol results in decreased activity of VKORC1L1 protein		 CTD PMID:29581108 NCBI chr12:26,717,959...26,768,193
Ensembl chr12:26,623,976...26,768,225 		JBrowse link
esculetin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agtr1a angiotensin II receptor, type 1a multiple interactions EXP esculetin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of AGTR1A mRNA]; esculetin inhibits the reaction [Dietary Fats results in increased expression of AGTR1A mRNA] CTD PMID:28946194 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946 		JBrowse link
G Agtr2 angiotensin II receptor, type 2 multiple interactions EXP esculetin inhibits the reaction [Dietary Fats results in increased expression of AGTR2 mRNA]; esculetin promotes the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of AGTR2 mRNA] CTD PMID:28946194 NCBI chr  X:112,119,876...112,124,060
Ensembl chr  X:112,120,228...112,124,057 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation ISO esculetin results in increased phosphorylation of AKT1 protein CTD PMID:24995577 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Alox15 arachidonate 15-lipoxygenase decreases expression ISO esculetin results in decreased expression of ALOX15 protein CTD PMID:30171828 NCBI chr10:55,060,169...55,068,885
Ensembl chr10:55,060,412...55,068,874 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases expression ISO esculetin results in increased expression of BAK1 protein CTD PMID:26388407 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
affects expression
affects localization		 ISO [esculetin co-treated with Paclitaxel] results in increased expression of BAX protein
esculetin results in increased expression of BAX protein
esculetin affects the expression of BAX protein
esculetin affects the localization of BAX protein		 CTD PMID:16051289 PMID:19786087 PMID:24995577 PMID:26388407 PMID:31313495 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator affects expression
decreases expression		 ISO esculetin affects the expression of BCL2 protein
esculetin results in decreased expression of BCL2 protein		 CTD PMID:24995577 PMID:26388407 PMID:31313495 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions
decreases expression		 ISO [esculetin co-treated with Paclitaxel] results in decreased expression of BCL2L1 protein
esculetin results in decreased expression of BCL2L1 protein		 CTD PMID:16051289 PMID:26388407 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions ISO [arsenic trioxide co-treated with esculetin] results in increased cleavage of BID protein CTD PMID:19428345 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720 		JBrowse link
G Bmp6 bone morphogenetic protein 6 multiple interactions EXP esculetin inhibits the reaction [Streptozocin results in decreased expression of BMP6 mRNA] CTD PMID:21450970 NCBI chr17:26,318,121...26,469,691
Ensembl chr17:26,318,569...26,470,365 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
increases activity		 ISO [esculetin co-treated with Paclitaxel] results in increased cleavage of and results in increased activity of CASP3 protein
esculetin results in increased cleavage of CASP3 protein
esculetin results in increased activity of CASP3 protein		 CTD PMID:16051289 PMID:24995577 PMID:26388407 PMID:31313495 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 increases cleavage ISO esculetin results in increased cleavage of CASP7 protein CTD PMID:31313495 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Casp8 caspase 8 multiple interactions ISO [esculetin co-treated with Paclitaxel] results in increased cleavage of and results in increased activity of CASP8 protein CTD PMID:16051289 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 increases activity
increases cleavage		 ISO esculetin results in increased activity of CASP9 protein
esculetin results in increased cleavage of CASP9 protein		 CTD PMID:24995577 PMID:26388407 PMID:31313495 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase multiple interactions EXP esculetin inhibits the reaction [Doxorubicin results in decreased expression of CAT mRNA] CTD PMID:38567888 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO esculetin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of CCL2 protein] CTD PMID:27769711 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccnd1 cyclin D1 decreases expression EXP
ISO		 esculetin results in decreased expression of CCND1 protein CTD PMID:21600278 PMID:31313495 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression
multiple interactions		 EXP esculetin results in decreased expression of CDK2 protein
esculetin promotes the reaction [CDKN1A protein binds to CDK2 protein]; SB 203580 inhibits the reaction [esculetin results in decreased expression of CDK2 protein]		 CTD PMID:21600278 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression
multiple interactions		 EXP esculetin results in decreased expression of CDK4 protein
esculetin promotes the reaction [CDKN1A protein binds to CDK4 protein]; SB 203580 inhibits the reaction [esculetin results in decreased expression of CDK4 protein]		 CTD PMID:21600278 NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression		 EXP
ISO		 esculetin promotes the reaction [CDKN1A protein binds to CDK2 protein]; esculetin promotes the reaction [CDKN1A protein binds to CDK4 protein]; SB 203580 inhibits the reaction [esculetin results in increased expression of CDKN1A protein] CTD PMID:21600278 PMID:31313495 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO esculetin results in increased expression of CDKN1B protein CTD PMID:31313495 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Comt catechol-O-methyltransferase increases methylation ISO COMT protein results in increased methylation of esculetin CTD PMID:11160877 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642 		JBrowse link
G Cycs cytochrome c, somatic multiple interactions ISO [arsenic trioxide co-treated with esculetin] affects the localization of CYCS protein; [esculetin co-treated with Paclitaxel] affects the localization of CYCS protein CTD PMID:16051289 PMID:19428345 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054 		JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO [esculetin co-treated with Paclitaxel] results in increased expression of FAS protein CTD PMID:16051289 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Faslg Fas ligand multiple interactions ISO [esculetin co-treated with Paclitaxel] results in increased expression of FASLG protein CTD PMID:16051289 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Fasn fatty acid synthase multiple interactions ISO esculetin promotes the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of FASN mRNA] CTD PMID:27769711 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261 		JBrowse link
G Fn1 fibronectin 1 multiple interactions EXP esculetin inhibits the reaction [Streptozocin results in increased expression of FN1 mRNA]; esculetin inhibits the reaction [Streptozocin results in increased expression of FN1 protein] CTD PMID:21450970 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678 		JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 multiple interactions ISO esculetin promotes the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased activity of G6PC1 protein] CTD PMID:27769711 NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO esculetin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of IL6 mRNA]; esculetin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of IL6 protein] CTD PMID:27769711 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation		 ISO
EXP		 [esculetin co-treated with Paclitaxel] results in decreased expression of MAPK1 protein; esculetin results in decreased phosphorylation of and results in decreased activity of MAPK1 protein
esculetin results in increased phosphorylation of MAPK1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [esculetin results in increased phosphorylation of MAPK1 protein]; SB 203580 inhibits the reaction [esculetin results in increased phosphorylation of MAPK1 protein]		 CTD PMID:16051289 PMID:21600278 PMID:24995577 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO [esculetin co-treated with Paclitaxel] results in decreased expression of MAPK14 protein; esculetin results in decreased phosphorylation of and results in decreased activity of MAPK14 protein CTD PMID:16051289 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation		 ISO
EXP		 [esculetin co-treated with Paclitaxel] results in decreased expression of MAPK3 protein; esculetin results in decreased phosphorylation of and results in decreased activity of MAPK3 protein
esculetin results in increased phosphorylation of MAPK3 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [esculetin results in increased phosphorylation of MAPK3 protein]; SB 203580 inhibits the reaction [esculetin results in increased phosphorylation of MAPK3 protein]		 CTD PMID:16051289 PMID:21600278 PMID:24995577 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions
increases phosphorylation
increases expression		 ISO [esculetin co-treated with Paclitaxel] results in increased expression of MAPK8 protein
esculetin results in increased phosphorylation of MAPK8 protein
esculetin results in increased expression of MAPK8 protein		 CTD PMID:16051289 PMID:19786087 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions
increases expression		 ISO [esculetin co-treated with Paclitaxel] results in increased expression of MAPK9 protein
esculetin results in increased expression of MAPK9 protein		 CTD PMID:16051289 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178 		JBrowse link
G Mmp13 matrix metallopeptidase 13 multiple interactions EXP esculetin inhibits the reaction [Streptozocin results in increased expression of MMP13 mRNA] CTD PMID:21450970 NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239 		JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions ISO esculetin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of MYD88 mRNA] CTD PMID:27769711 NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases localization
affects localization		 ISO esculetin results in increased localization of NFE2L2 protein
esculetin affects the localization of NFE2L2 protein		 CTD PMID:20933534 PMID:30171828 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 affects localization ISO esculetin affects the localization of NFKB1 protein CTD PMID:30171828 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO esculetin promotes the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA] CTD PMID:16212885 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions EXP esculetin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of NOS3 mRNA]; esculetin inhibits the reaction [Dietary Fats results in decreased expression of NOS3 mRNA] CTD PMID:28946194 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases expression		 ISO esculetin results in increased expression of and results in increased activity of NQO1 protein
esculetin results in increased expression of NQO1 mRNA		 CTD PMID:20933534 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO esculetin results in increased cleavage of PARP1 protein CTD PMID:26388407 PMID:31313495 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions EXP
ISO		 esculetin inhibits the reaction [Streptozocin results in decreased expression of PPARG protein]; esculetin inhibits the reaction [Streptozocin results in increased expression of PPARG protein]
esculetin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of PPARG mRNA]		 CTD PMID:21450970 PMID:27769711 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit affects localization ISO esculetin affects the localization of RELA protein CTD PMID:30171828 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Sod1 superoxide dismutase 1 affects expression ISO esculetin affects the expression of SOD1 protein CTD PMID:30171828 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sp1 Sp1 transcription factor decreases expression ISO esculetin results in decreased expression of SP1 protein CTD PMID:31313495 NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP esculetin inhibits the reaction [Streptozocin results in increased expression of TGFB1 protein] CTD PMID:21450970 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO esculetin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of TLR4 mRNA] CTD PMID:27769711 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO esculetin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of TNF mRNA]; esculetin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of TNF protein] CTD PMID:27769711 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfrsf10b TNF receptor superfamily member 10b increases expression ISO esculetin results in increased expression of TNFRSF10A protein CTD PMID:19786087 NCBI chr15:44,840,386...44,868,318
Ensembl chr15:44,840,386...44,867,467 		JBrowse link
G Tp53 tumor protein p53 increases degradation
increases expression		 ISO esculetin results in increased degradation of TP53 protein
esculetin results in increased expression of TP53 protein		 CTD PMID:14634213 PMID:31313495 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Ugt2b15 UDP glucuronosyltransferase family 2 member B15 increases metabolic processing EXP UGT2B15 protein results in increased metabolism of esculetin CTD PMID:7574722 NCBI chr14:20,768,015...20,783,599
Ensembl chr14:20,768,015...20,783,589 		JBrowse link
G Usp16 ubiquitin specific peptidase 16 multiple interactions EXP esculetin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of USP16 mRNA]; esculetin inhibits the reaction [Dietary Fats results in increased expression of USP16 mRNA] CTD PMID:28946194 NCBI chr11:26,681,359...26,711,313
Ensembl chr11:26,681,414...26,710,539 		JBrowse link
G Usp22 ubiquitin specific peptidase 22 multiple interactions EXP esculetin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of USP22 mRNA]; esculetin inhibits the reaction [Dietary Fats results in increased expression of USP22 mRNA] CTD PMID:28946194 NCBI chr10:45,828,619...45,855,468
Ensembl chr10:45,828,622...45,855,497 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions EXP esculetin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of VCAM1 mRNA]; esculetin inhibits the reaction [Dietary Fats results in increased expression of VCAM1 mRNA] CTD PMID:28946194 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
ethyl biscoumacetate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F10 coagulation factor X multiple interactions
decreases expression		 EXP Vitamin K 3 inhibits the reaction [Ethyl Biscoumacetate results in decreased expression of F10 protein] CTD PMID:6768192 NCBI chr16:76,468,834...76,488,141
Ensembl chr16:76,468,838...76,488,141 		JBrowse link
fraxetin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation		 ISO fraxetin inhibits the reaction [Isoflurane results in decreased phosphorylation of AKT1 protein]
fraxetin results in decreased phosphorylation of AKT1 protein		 CTD PMID:34553399 PMID:37867445 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator decreases expression
increases expression
increases expression 		ISO fraxetin results in decreased expression of BAX protein
fraxetin results in increased expression of BAX mRNA; fraxetin results in increased expression of BAX protein
Fraxetin increases expression of BAX protein in colorectum		 CTD
RGD		 PMID:15996779 PMID:37867445 PMID:32504672 RGD:125097526 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Fraxetin decreases expression of BCL2 protein in colorectum
fraxetin results in decreased expression of BCL2 mRNA; fraxetin results in decreased expression of BCL2 protein		 CTD
RGD		 PMID:37867445 PMID:32504672 RGD:125097526 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 decreases activity
increases cleavage		 ISO fraxetin results in decreased activity of CASP3 protein
fraxetin results in increased cleavage of CASP3 protein		 CTD PMID:15996779 PMID:37867445 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 decreases activity ISO fraxetin results in decreased activity of CASP9 protein CTD PMID:15996779 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase multiple interactions ISO fraxetin inhibits the reaction [Rotenone results in increased expression of and results in increased activity of CAT protein] CTD PMID:15904944 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccna2 cyclin A2 decreases expression ISO Fraxetin decreases expression of CCNA2 protein in colorectum RGD PMID:32504672 RGD:125097526 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577 		JBrowse link
G Ccne1 cyclin E1 decreases expression ISO Fraxetin decreases expression of CCNE1 protein in colorectum RGD PMID:32504672 RGD:125097526 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101 		JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO Fraxetin decreases expression of CDK2 protein in colorectum RGD PMID:32504672 RGD:125097526 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403 		JBrowse link
G Cycs cytochrome c, somatic affects localization ISO fraxetin affects the localization of CYCS protein CTD PMID:15996779 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO fraxetin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL6 mRNA] CTD PMID:30496664 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Jak2 Janus kinase 2 decreases phosphorylation ISO Fraxetin decreases phosphorylation of JAK2 protein in colorectum RGD PMID:32504672 RGD:125097526 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 decreases phosphorylation ISO fraxetin results in decreased phosphorylation of MAPK8 protein CTD PMID:37867445 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mki67 marker of proliferation Ki-67 decreases expression ISO fraxetin results in decreased expression of MKI67 protein CTD PMID:37867445 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO fraxetin results in increased cleavage of PARP1 protein CTD PMID:37867445 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Skp2 S-phase kinase associated protein 2 decreases expression ISO Fraxetin decreases expression of SKP2 mRNA and protein in colorectum RGD PMID:32504672 RGD:125097526 NCBI chr 2:58,161,226...58,189,293
Ensembl chr 2:58,161,229...58,189,338 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO fraxetin inhibits the reaction [Rotenone results in increased expression of and results in increased activity of SOD2 protein] CTD PMID:15904944 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 decreases phosphorylation ISO Fraxetin decreases phosphorylation of STAT3 protein in colorectum RGD PMID:32504672 RGD:125097526 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO fraxetin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of TNF mRNA] CTD PMID:30496664 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
novobiocin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions
decreases activity		 EXP
ISO		 [Novobiocin results in decreased activity of ABCG2 protein] which results in decreased secretion of Rosuvastatin Calcium
[Novobiocin results in decreased activity of ABCG2 protein] which results in decreased export of Mitoxantrone; Novobiocin inhibits the reaction [5-Methoxypsoralen results in decreased activity of ABCG2 protein]; Novobiocin inhibits the reaction [[5-Methoxypsoralen results in decreased activity of ABCG2 protein] which results in decreased export of and results in increased abundance of Mitoxantrone]; Novobiocin inhibits the reaction [[Methoxsalen results in decreased activity of ABCG2 protein] which results in decreased export of and results in increased abundance of Mitoxantrone]; Novobiocin inhibits the reaction [ABCG2 protein results in increased uptake of lucifer yellow]; Novobiocin inhibits the reaction [Methoxsalen results in decreased activity of ABCG2 protein]		 CTD PMID:19853032 PMID:29079042 PMID:32305507 PMID:35550413 PMID:38367674 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases degradation ISO Novobiocin analog results in increased degradation of AKT1 protein CTD PMID:20711301 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Cd38 CD38 molecule increases expression ISO Novobiocin results in increased expression of CD38 mRNA; Novobiocin results in increased expression of CD38 protein CTD PMID:11853877 NCBI chr14:67,172,062...67,212,328
Ensembl chr14:67,172,063...67,211,986 		JBrowse link
G Cdh2 cadherin 2 decreases expression ISO Novobiocin results in decreased expression of CDH2 protein CTD PMID:11853877 NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167 		JBrowse link
G Ggt1 gamma-glutamyltransferase 1 increases activity ISO Novobiocin results in increased activity of GGT1 protein CTD PMID:1739614 NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442 		JBrowse link
phenprocoumon term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F10 coagulation factor X decreases activity EXP Phenprocoumon results in decreased activity of F10 protein CTD PMID:3490277 NCBI chr16:76,468,834...76,488,141
Ensembl chr16:76,468,838...76,488,141 		JBrowse link
G F2 coagulation factor II, thrombin decreases activity EXP Phenprocoumon results in decreased activity of F2 protein CTD PMID:3490277 NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486 		JBrowse link
G F5 coagulation factor V decreases activity EXP Phenprocoumon results in decreased activity of F5 protein CTD PMID:3490277 NCBI chr13:76,513,509...76,583,106
Ensembl chr13:76,513,255...76,582,317 		JBrowse link
G F7 coagulation factor VII decreases activity EXP Phenprocoumon results in decreased activity of F7 protein CTD PMID:3490277 NCBI chr16:76,489,775...76,500,636
Ensembl chr16:76,489,717...76,500,610 		JBrowse link
G F9 coagulation factor IX decreases activity EXP Phenprocoumon results in decreased activity of F9 protein CTD PMID:3490277 NCBI chr  X:138,352,334...138,396,835
Ensembl chr  X:138,352,298...138,396,835 		JBrowse link
G Ggcx gamma-glutamyl carboxylase increases activity EXP Phenprocoumon results in increased activity of GGCX protein CTD PMID:3490277 NCBI chr 4:104,469,737...104,485,631
Ensembl chr 4:104,469,765...104,487,063 		JBrowse link
G Hsf1 heat shock transcription factor 1 decreases activity ISO Phenprocoumon results in decreased activity of HSF1 protein CTD PMID:34170685 NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011 		JBrowse link
G Vkorc1 vitamin K epoxide reductase complex, subunit 1 affects response to substance
decreases activity
multiple interactions
decreases response to substance		 ISO VKORC1 gene polymorphism affects the susceptibility to Phenprocoumon; VKORC1 intron SNP affects the susceptibility to Phenprocoumon
Phenprocoumon results in decreased activity of VKORC1 protein
Phenprocoumon inhibits the reaction [VKORC1 protein results in increased reduction of Vitamin K 1]
VKORC1 protein polymorphism results in decreased susceptibility to Phenprocoumon		 CTD PMID:15536456 PMID:16201835 PMID:17036862 PMID:18698879 PMID:29581108 NCBI chr 1:182,502,491...182,505,012
Ensembl chr 1:182,500,844...182,505,008 		JBrowse link
G Vkorc1l1 vitamin K epoxide reductase complex, subunit 1-like 1 decreases activity
multiple interactions		 ISO Phenprocoumon results in decreased activity of VKORC1L1 protein
Phenprocoumon inhibits the reaction [VKORC1L1 protein results in increased reduction of Vitamin K 1]		 CTD PMID:29581108 NCBI chr12:26,717,959...26,768,193
Ensembl chr12:26,623,976...26,768,225 		JBrowse link
scoparone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO scoparone affects the reaction [[Dietary Fats co-treated with Dietary Sugars co-treated with Diethylnitrosamine] results in increased phosphorylation of AKT1 protein] CTD PMID:37436232 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Alb albumin multiple interactions ISO scoparone inhibits the reaction [[Dietary Fats co-treated with Dietary Sugars co-treated with Diethylnitrosamine] results in decreased expression of ALB protein] CTD PMID:37436232 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO scoparone results in increased expression of BAX protein CTD PMID:37449671 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO scoparone results in decreased expression of BCL2 protein CTD PMID:37449671 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 increases cleavage ISO scoparone results in increased cleavage of CASP3 protein CTD PMID:37449671 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO scoparone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CCL2 mRNA]; scoparone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of CCL2 protein]
scoparone inhibits the reaction [Diethylnitrosamine promotes the reaction [[Dietary Fats co-treated with Dietary Sugars] results in increased expression of CCL2 mRNA]]; scoparone inhibits the reaction [Diethylnitrosamine promotes the reaction [[Dietary Fats co-treated with Dietary Sugars] results in increased expression of CCL2 protein]]		 CTD PMID:16376386 PMID:37436232 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Cdc42 cell division cycle 42 decreases expression ISO scoparone results in decreased expression of CDC42 mRNA CTD PMID:37449671 NCBI chr 5:149,555,069...149,593,239
Ensembl chr 5:149,553,724...149,593,111 		JBrowse link
G Dct dopachrome tautomerase increases expression ISO scoparone results in increased expression of DCT mRNA CTD PMID:17049123 NCBI chr15:95,062,006...95,100,863
Ensembl chr15:95,062,003...95,100,836 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO [Dietary Sugars co-treated with Dietary Fats co-treated with scoparone] results in increased expression of GPT protein; scoparone inhibits the reaction [Diethylnitrosamine promotes the reaction [[Dietary Sugars co-treated with Dietary Fats] results in increased expression of GPT protein]] CTD PMID:37436232 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Ifnb1 interferon beta 1 multiple interactions ISO scoparone inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Galactose] results in increased expression of IFNB1 protein] CTD PMID:23535186 NCBI chr 5:103,020,758...103,021,595
Ensembl chr 5:103,020,969...103,021,523 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO scoparone affects the reaction [[Dietary Fats co-treated with Dietary Sugars co-treated with Diethylnitrosamine] results in increased metabolism of IL1B protein] CTD PMID:37436232 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO scoparone inhibits the reaction [[Galactose co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of IL6 protein] CTD PMID:23535186 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Irf3 interferon regulatory factor 3 multiple interactions ISO scoparone inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Galactose] results in increased phosphorylation of IRF3 protein] CTD PMID:23535186 NCBI chr 1:95,479,966...95,484,926
Ensembl chr 1:95,479,821...95,484,935 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO scoparone inhibits the reaction [[Galactose co-treated with lipopolysaccharide, Escherichia coli O111 B4] affects the localization of and results in increased expression of JUN protein modified form] CTD PMID:23535186 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO scoparone affects the reaction [[Dietary Fats co-treated with Dietary Sugars co-treated with Diethylnitrosamine] results in increased phosphorylation of MAPK14 protein] CTD PMID:37436232 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589 		JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression ISO scoparone results in decreased expression of MMP2 mRNA CTD PMID:37449671 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression
multiple interactions		 ISO scoparone results in decreased expression of MMP9 mRNA
scoparone affects the reaction [[Dietary Fats co-treated with Dietary Sugars co-treated with Diethylnitrosamine] results in increased expression of MMP9 protein]; scoparone inhibits the reaction [Diethylnitrosamine promotes the reaction [[Dietary Fats co-treated with Dietary Sugars] results in increased expression of MMP9 mRNA]]		 CTD PMID:37436232 PMID:37449671 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions ISO scoparone inhibits the reaction [[Galactose co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of MYD88 protein] CTD PMID:23535186 NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415 		JBrowse link
G Myl1 myosin, light chain 1 decreases phosphorylation ISO scoparone results in decreased phosphorylation of MYL1 protein CTD PMID:37449671 NCBI chr 9:68,437,514...68,458,256
Ensembl chr 9:68,437,517...68,458,261 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO scoparone inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of NFKB1 protein] CTD PMID:16376386 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO scoparone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of NFKBIA protein] CTD PMID:16376386 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO scoparone inhibits the reaction [Diethylnitrosamine promotes the reaction [[Dietary Fats co-treated with Dietary Sugars] results in increased expression of NOS2 mRNA]] CTD PMID:37436232 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 increases expression
increases activity		 ISO scoparone results in increased expression of NR1H4 mRNA
scoparone results in increased activity of NR1H4 protein		 CTD PMID:36542898 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO scoparone results in increased cleavage of PARP1 protein CTD PMID:37449671 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pfkp phosphofructokinase, platelet decreases expression ISO scoparone results in decreased expression of PFKP mRNA CTD PMID:37449671 NCBI chr17:63,729,743...63,794,026
Ensembl chr17:63,729,780...63,794,018 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO scoparone inhibits the reaction [Diethylnitrosamine promotes the reaction [[Dietary Fats co-treated with Dietary Sugars] results in increased expression of PTGS2 mRNA]] CTD PMID:37436232 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rel REL proto-oncogene, NF-kB subunit multiple interactions ISO scoparone inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of REL protein] CTD PMID:16376386 NCBI chr14:97,690,105...97,721,194
Ensembl chr14:97,695,161...97,720,892 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO scoparone affects the reaction [[Dietary Fats co-treated with Dietary Sugars co-treated with Diethylnitrosamine] results in increased phosphorylation of RELA protein]; scoparone inhibits the reaction [[Galactose co-treated with lipopolysaccharide, Escherichia coli O111 B4] affects the localization of and results in increased expression of RELA protein]; scoparone inhibits the reaction [Diethylnitrosamine promotes the reaction [[Dietary Fats co-treated with Dietary Sugars] results in increased expression of RELA mRNA]]; scoparone inhibits the reaction [Diethylnitrosamine promotes the reaction [[Dietary Fats co-treated with Dietary Sugars] results in increased expression of RELA protein]]
scoparone inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of RELA protein]; scoparone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of RELA protein]		 CTD PMID:16376386 PMID:23535186 PMID:37436232 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Rhoa ras homolog family member A decreases expression ISO scoparone results in decreased expression of RHOA mRNA; scoparone results in decreased expression of RHOA protein CTD PMID:37449671 NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746 		JBrowse link
G Rock1 Rho-associated coiled-coil containing protein kinase 1 decreases expression ISO scoparone results in decreased expression of ROCK1 mRNA; scoparone results in decreased expression of ROCK1 protein CTD PMID:37449671 NCBI chr18:1,114,532...1,236,345
Ensembl chr18:1,115,905...1,235,571 		JBrowse link
G Ticam1 TIR domain containing adaptor molecule 1 multiple interactions ISO scoparone inhibits the reaction [[Galactose co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of TICAM1 protein] CTD PMID:23535186 NCBI chr 9:1,102,559...1,111,023
Ensembl chr 9:1,102,366...1,123,147 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO scoparone inhibits the reaction [[Galactose co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of TLR4 protein] CTD PMID:23535186 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO scoparone inhibits the reaction [[Galactose co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of TNF protein]; scoparone inhibits the reaction [Diethylnitrosamine promotes the reaction [[Dietary Fats co-treated with Dietary Sugars] results in increased expression of TNF mRNA]]; scoparone inhibits the reaction [Diethylnitrosamine promotes the reaction [[Dietary Fats co-treated with Dietary Sugars] results in increased expression of TNF protein]] CTD PMID:23535186 PMID:37436232 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tyr tyrosinase multiple interactions
increases expression		 ISO N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [scoparone results in increased expression of TYR protein]; scoparone results in increased expression of and results in increased activity of TYR protein
scoparone results in increased expression of TYR mRNA		 CTD PMID:17049123 NCBI chr 1:141,115,036...141,210,207
Ensembl chr 1:141,115,036...141,210,207 		JBrowse link
G Tyrp1 tyrosinase-related protein 1 increases expression ISO scoparone results in increased expression of TYRP1 mRNA CTD PMID:17049123 NCBI chr 5:95,280,982...95,299,516
Ensembl chr 5:95,280,982...95,299,516 		JBrowse link
scopoletin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaa1a acetyl-CoA acyltransferase 1A multiple interactions EXP Scopoletin inhibits the reaction [Ethanol results in decreased expression of ACAA1A mRNA] CTD PMID:26115886 NCBI chr 8:119,079,401...119,088,626
Ensembl chr 8:119,079,775...119,088,624 		JBrowse link
G Acaca acetyl-CoA carboxylase alpha multiple interactions EXP Scopoletin inhibits the reaction [Ethanol results in decreased phosphorylation of ACACA protein] CTD PMID:26115886 NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457 		JBrowse link
G Acox1 acyl-CoA oxidase 1 multiple interactions EXP Scopoletin inhibits the reaction [Ethanol results in decreased expression of ACOX1 mRNA] CTD PMID:26115886 NCBI chr10:101,406,197...101,431,252
Ensembl chr10:101,406,197...101,431,232 		JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 multiple interactions EXP Scopoletin inhibits the reaction [Ethanol results in decreased expression of ACSL1 mRNA] CTD PMID:26115886 NCBI chr16:45,755,246...45,821,541
Ensembl chr16:45,755,254...45,821,541 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions EXP Scopoletin inhibits the reaction [Ethanol results in decreased expression of ADIPOQ mRNA]; Scopoletin inhibits the reaction [Ethanol results in decreased expression of ADIPOQ protein] CTD PMID:26115886 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G Adipor2 adiponectin receptor 2 multiple interactions
increases expression 		EXP Scopoletin inhibits the reaction [Ethanol results in decreased expression of ADIPOR2 mRNA]; Scopoletin inhibits the reaction [Ethanol results in decreased expression of ADIPOR2 protein]
scopoletin increases expression of adipor2 mRNA and protein in epididymal white adipose tissue of alcohol fed rats		 CTD
RGD		 PMID:26115886 PMID:26115886 RGD:25330099 NCBI chr 4:152,524,604...152,588,848
Ensembl chr 4:152,524,623...152,559,355 		JBrowse link
G Atf4 activating transcription factor 4 decreases expression EXP Scopoletin results in decreased expression of ATF4 mRNA CTD PMID:34979142 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP Scopoletin inhibits the reaction [Glucose results in increased expression of BAX protein] CTD PMID:37619648 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP Scopoletin inhibits the reaction [Glucose results in decreased expression of BCL2 protein] CTD PMID:37619648 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP
ISO		 Scopoletin inhibits the reaction [Glucose results in increased cleavage of CASP3 protein]; Scopoletin inhibits the reaction [Glycochenodeoxycholic Acid results in increased activity of CASP3 protein]
Scopoletin inhibits the reaction [Palmitic Acid results in increased activity of CASP3 protein]		 CTD PMID:34979142 PMID:37619648 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 multiple interactions EXP Scopoletin inhibits the reaction [Glucose results in increased expression of CASP9 protein] CTD PMID:37619648 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cidea cell death-inducing DFFA-like effector a multiple interactions EXP Scopoletin inhibits the reaction [Alcohols affects the expression of CIDEA mRNA] CTD PMID:26115886 NCBI chr18:60,894,917...60,920,485
Ensembl chr18:60,894,874...60,920,481 		JBrowse link
G Cycs cytochrome c, somatic multiple interactions EXP Scopoletin inhibits the reaction [Glucose results in increased expression of CYCS protein] CTD PMID:37619648 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions EXP Scopoletin inhibits the reaction [Glycochenodeoxycholic Acid results in increased expression of DDIT3 mRNA]; Scopoletin inhibits the reaction [Palmitic Acid results in increased expression of DDIT3 mRNA] CTD PMID:34979142 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Fasn fatty acid synthase multiple interactions EXP Scopoletin inhibits the reaction [Ethanol results in increased expression of FASN mRNA] CTD PMID:26115886 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP Scopoletin inhibits the reaction [Ethanol results in increased activity of GPT protein] CTD PMID:26115886 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions
increases expression		 EXP [Glycochenodeoxycholic Acid co-treated with Scopoletin] results in increased expression of HSPA5 mRNA; [Scopoletin co-treated with Palmitic Acid] results in increased expression of HSPA5 mRNA
Scopoletin results in increased expression of HSPA5 mRNA		 CTD PMID:34979142 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Il10 interleukin 10 multiple interactions EXP Scopoletin inhibits the reaction [Ethanol results in decreased expression of IL10 protein] CTD PMID:26115886 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP Scopoletin inhibits the reaction [Ethanol results in increased expression of IL6 mRNA]; Scopoletin inhibits the reaction [Ethanol results in increased expression of IL6 protein] CTD PMID:26115886 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Lipe lipase E, hormone sensitive type multiple interactions EXP Scopoletin inhibits the reaction [Ethanol results in increased phosphorylation of LIPE protein] CTD PMID:26115886 NCBI chr 1:80,965,612...80,984,313
Ensembl chr 1:80,965,627...80,984,310 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP Scopoletin inhibits the reaction [Glycochenodeoxycholic Acid results in increased phosphorylation of MAPK1 protein]; Scopoletin inhibits the reaction [Palmitic Acid results in increased phosphorylation of MAPK1 protein] CTD PMID:34979142 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP Scopoletin inhibits the reaction [Glycochenodeoxycholic Acid results in increased phosphorylation of MAPK3 protein]; Scopoletin inhibits the reaction [Palmitic Acid results in increased phosphorylation of MAPK3 protein] CTD PMID:34979142 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions EXP Scopoletin inhibits the reaction [Glucose results in increased phosphorylation of MAPK8 protein]; Scopoletin inhibits the reaction [Glycochenodeoxycholic Acid results in increased phosphorylation of MAPK8 protein]; Scopoletin inhibits the reaction [Palmitic Acid results in increased phosphorylation of MAPK8 protein] CTD PMID:34979142 PMID:37619648 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions EXP Scopoletin inhibits the reaction [Ethanol results in increased expression of MYD88 mRNA] CTD PMID:26115886 NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions EXP Scopoletin inhibits the reaction [Glucose results in decreased expression of PARP1 protein] CTD PMID:37619648 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pnpla2 patatin-like phospholipase domain containing 2 multiple interactions EXP Scopoletin inhibits the reaction [Ethanol results in increased expression of PNPLA2 mRNA] CTD PMID:26115886 NCBI chr 1:196,552,723...196,557,805
Ensembl chr 1:196,552,723...196,557,805 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions EXP Scopoletin inhibits the reaction [Ethanol results in decreased expression of PPARA mRNA] CTD PMID:26115886 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions EXP Scopoletin inhibits the reaction [Ethanol results in increased expression of SREBF1 mRNA] CTD PMID:26115886 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650 		JBrowse link
G Ticam1 TIR domain containing adaptor molecule 1 multiple interactions EXP Scopoletin inhibits the reaction [Ethanol results in increased expression of TICAM1 mRNA] CTD PMID:26115886 NCBI chr 9:1,102,559...1,111,023
Ensembl chr 9:1,102,366...1,123,147 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions EXP Scopoletin inhibits the reaction [Ethanol results in increased expression of TLR4 mRNA] CTD PMID:26115886 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP Scopoletin inhibits the reaction [Ethanol results in increased expression of TNF mRNA]; Scopoletin inhibits the reaction [Ethanol results in increased expression of TNF protein] CTD PMID:26115886 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of Scopoletin CTD PMID:15802387 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of Scopoletin CTD PMID:15802387 NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 increases glucuronidation ISO UGT1A6 protein results in increased glucuronidation of Scopoletin CTD PMID:15802387 NCBI chr 9:88,747,213...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of Scopoletin CTD PMID:15044611 PMID:15802387 NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt2b15 UDP glucuronosyltransferase family 2 member B15 increases metabolic processing EXP UGT2B15 protein results in increased metabolism of Scopoletin CTD PMID:7574722 NCBI chr14:20,768,015...20,783,599
Ensembl chr14:20,768,015...20,783,589 		JBrowse link
G Xpc XPC complex subunit, DNA damage recognition and repair factor affects response to substance ISO XPC protein affects the susceptibility to Scopoletin CTD PMID:22280988 NCBI chr 4:123,993,670...124,020,922
Ensembl chr 4:123,993,666...124,021,010 		JBrowse link
scopolin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ide insulin degrading enzyme multiple interactions ISO scopolin binds to and affects the activity of IDE protein CTD PMID:23146021 NCBI chr 1:235,002,984...235,102,448
Ensembl chr 1:234,995,351...235,102,440 		JBrowse link
G Urod uroporphyrinogen decarboxylase multiple interactions ISO scopolin binds to and affects the activity of UROD protein CTD PMID:23209648 NCBI chr 5:130,464,695...130,468,783
Ensembl chr 5:130,455,217...130,468,808 		JBrowse link
umbelliferone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions ISO 7-hydroxycoumarin inhibits the reaction [Dietary Fats results in decreased expression of ADIPOQ protein] CTD PMID:24661945 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 multiple interactions
increases expression		 ISO 7-hydroxycoumarin inhibits the reaction [AKR1C3 mutant form results in increased susceptibility to 4-hydroxy-2-nonenal]; 7-hydroxycoumarin inhibits the reaction [AKR1C3 mutant form results in increased susceptibility to Hydrogen Peroxide]
7-hydroxycoumarin results in increased expression of AKR1C3 mRNA; 7-hydroxycoumarin results in increased expression of AKR1C3 protein		 CTD PMID:22964423 PMID:28263721 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873 		JBrowse link
G Akr7a2 aldo-keto reductase family 7, member A2 multiple interactions
increases expression		 ISO 7-hydroxycoumarin affects the reaction [AKR7A2 mutant form results in increased susceptibility to 4-hydroxy-2-nonenal]
7-hydroxycoumarin results in increased expression of AKR7A2 mRNA; 7-hydroxycoumarin results in increased expression of AKR7A2 protein		 CTD PMID:22964423 PMID:28263721 PMID:30849339 NCBI chr 5:151,552,375...151,560,914
Ensembl chr 5:151,552,343...151,560,909 		JBrowse link
G Akr7a3 aldo-keto reductase family 7 member A3 increases expression ISO 7-hydroxycoumarin results in increased expression of AKR7A3 mRNA CTD PMID:28263721 NCBI chr 5:151,590,968...151,601,394
Ensembl chr 5:151,584,479...151,601,394 		JBrowse link
G Atf4 activating transcription factor 4 decreases expression EXP 7-hydroxycoumarin results in decreased expression of ATF4 mRNA CTD PMID:34979142 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions		 ISO
EXP		 7-hydroxycoumarin results in increased expression of BAX protein
2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [7-hydroxycoumarin inhibits the reaction [Glycerol results in increased expression of BAX protein]]; 7-hydroxycoumarin inhibits the reaction [Glycerol results in increased expression of BAX protein]		 CTD PMID:15964220 PMID:34409680 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions		 ISO
EXP		 7-hydroxycoumarin results in decreased expression of BCL2 protein
2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [7-hydroxycoumarin inhibits the reaction [Glycerol results in decreased expression of BCL2 protein]]; 7-hydroxycoumarin inhibits the reaction [Glycerol results in decreased expression of BCL2 protein]		 CTD PMID:15964220 PMID:34409680 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity		 EXP
ISO		 7-hydroxycoumarin inhibits the reaction [Glycochenodeoxycholic Acid results in increased activity of CASP3 protein]
7-hydroxycoumarin inhibits the reaction [Palmitic Acid results in increased activity of CASP3 protein]
7-hydroxycoumarin results in increased activity of CASP3 protein		 CTD PMID:34979142 PMID:37704181 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cat catalase multiple interactions ISO 7-hydroxycoumarin inhibits the reaction [Dietary Fats results in decreased activity of CAT protein] CTD PMID:24661945 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO 7-hydroxycoumarin results in decreased expression of CCND1 protein CTD PMID:11679177 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 increases expression
multiple interactions		 EXP 7-hydroxycoumarin results in increased expression of CREB1 mRNA
7-hydroxycoumarin inhibits the reaction [Cisplatin results in decreased expression of CREB1 mRNA]		 CTD PMID:33522649 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Cygb cytoglobin multiple interactions
increases expression		 EXP 7-hydroxycoumarin inhibits the reaction [Cisplatin results in decreased expression of CYGB protein]
7-hydroxycoumarin results in increased expression of CYGB protein		 CTD PMID:33522649 NCBI chr10:101,877,675...101,887,442
Ensembl chr10:101,877,676...101,887,442 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO [CYP1A2 protein results in increased metabolism of coumarin] which results in increased abundance of 7-hydroxycoumarin CTD PMID:34334558 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO 7-hydroxycoumarin inhibits the reaction [Dietary Fats results in increased activity of CYP2E1 protein] CTD PMID:24661945 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions EXP 7-hydroxycoumarin inhibits the reaction [Glycochenodeoxycholic Acid results in increased expression of DDIT3 mRNA] CTD PMID:34979142 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Foxo3 forkhead box O3 multiple interactions EXP 7-hydroxycoumarin inhibits the reaction [Cisplatin results in increased expression of FOXO3 mRNA] CTD PMID:33522649 NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561 		JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 multiple interactions EXP 7-hydroxycoumarin inhibits the reaction [Cisplatin results in increased expression of HAVCR1 protein] CTD PMID:33522649 NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions EXP 7-hydroxycoumarin inhibits the reaction [Isoproterenol results in increased activity of HMGCR protein] CTD PMID:26995004 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions
increases expression		 EXP [7-hydroxycoumarin co-treated with Palmitic Acid] results in increased expression of HSPA5 mRNA
7-hydroxycoumarin results in increased expression of HSPA5 mRNA		 CTD PMID:34979142 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions EXP 7-hydroxycoumarin inhibits the reaction [Cisplatin results in increased expression of IKBKB protein] CTD PMID:33522649 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP 7-hydroxycoumarin inhibits the reaction [Cisplatin results in increased expression of IL1B protein] CTD PMID:33522649 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP 7-hydroxycoumarin inhibits the reaction [Streptozocin results in increased expression of IL6 protein] CTD PMID:36650709 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Ins1 insulin 1 multiple interactions EXP 7-hydroxycoumarin inhibits the reaction [Streptozocin results in decreased expression of INS1 protein] CTD PMID:36650709 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536 		JBrowse link
G Jak2 Janus kinase 2 multiple interactions EXP 7-hydroxycoumarin inhibits the reaction [Streptozocin results in increased expression of JAK2 mRNA]; 7-hydroxycoumarin inhibits the reaction [Streptozocin results in increased expression of JAK2 protein] CTD PMID:36650709 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP 7-hydroxycoumarin inhibits the reaction [Glycochenodeoxycholic Acid results in increased phosphorylation of MAPK1 protein]; 7-hydroxycoumarin inhibits the reaction [Palmitic Acid results in increased phosphorylation of MAPK1 protein] CTD PMID:34979142 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP 7-hydroxycoumarin inhibits the reaction [Glycochenodeoxycholic Acid results in increased phosphorylation of MAPK3 protein]; 7-hydroxycoumarin inhibits the reaction [Palmitic Acid results in increased phosphorylation of MAPK3 protein] CTD PMID:34979142 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions EXP 7-hydroxycoumarin inhibits the reaction [Glycochenodeoxycholic Acid results in increased phosphorylation of MAPK8 protein]; 7-hydroxycoumarin inhibits the reaction [Palmitic Acid results in increased phosphorylation of MAPK8 protein] CTD PMID:34979142 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mpo myeloperoxidase multiple interactions
increases oxidation		 ISO [4-aminobenzhydrazide results in decreased activity of MPO protein] which affects the susceptibility to 7-hydroxycoumarin
MPO protein results in increased oxidation of 7-hydroxycoumarin		 CTD PMID:23994743 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
increases expression		 ISO
EXP		 7-hydroxycoumarin results in increased expression of and affects the localization of NFE2L2 protein
7-hydroxycoumarin results in increased expression of NFE2L2 mRNA; 7-hydroxycoumarin results in increased expression of NFE2L2 protein
7-hydroxycoumarin inhibits the reaction [Cisplatin results in decreased expression of NFE2L2 mRNA]; 7-hydroxycoumarin inhibits the reaction [Cisplatin results in decreased expression of NFE2L2 protein]		 CTD PMID:28263721 PMID:33522649 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkbia NFKB inhibitor alpha decreases expression
multiple interactions		 EXP 7-hydroxycoumarin results in decreased expression of NFKBIA protein
7-hydroxycoumarin inhibits the reaction [Cisplatin results in decreased expression of NFKBIA protein]		 CTD PMID:33522649 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions
increases expression		 EXP 7-hydroxycoumarin inhibits the reaction [Cisplatin results in decreased expression of PPARG mRNA]
7-hydroxycoumarin results in increased expression of PPARG mRNA		 CTD PMID:33522649 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP 7-hydroxycoumarin inhibits the reaction [Cisplatin results in increased expression of RELA protein] CTD PMID:33522649 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Sirt1 sirtuin 1 increases expression
multiple interactions		 EXP 7-hydroxycoumarin results in increased expression of SIRT1 mRNA
7-hydroxycoumarin inhibits the reaction [Cisplatin results in decreased expression of SIRT1 mRNA]		 CTD PMID:33522649 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions EXP 7-hydroxycoumarin inhibits the reaction [Streptozocin results in increased expression of STAT3 mRNA]; 7-hydroxycoumarin inhibits the reaction [Streptozocin results in increased expression of STAT3 protein] CTD PMID:36650709 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 increases sulfation ISO
EXP		 SULT1A1 protein results in increased sulfation of 7-hydroxycoumarin CTD PMID:11181495 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP 7-hydroxycoumarin inhibits the reaction [Streptozocin results in increased expression of TGFB1 mRNA]; 7-hydroxycoumarin inhibits the reaction [Streptozocin results in increased expression of TGFB1 protein] CTD PMID:36650709 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP 7-hydroxycoumarin inhibits the reaction [Cisplatin results in increased expression of TNF protein]; 7-hydroxycoumarin inhibits the reaction [Streptozocin results in increased expression of TNF protein] CTD PMID:33522649 PMID:36650709 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 affects metabolic processing
increases metabolic processing		 EXP UGT1A6 gene polymorphism affects the metabolism of 7-hydroxycoumarin
UGT1A6 protein results in increased metabolism of 7-hydroxycoumarin		 CTD PMID:9429234 NCBI chr 9:88,747,213...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a7c UDP glucuronosyltransferase 1 family, polypeptide A7C increases glucuronidation EXP UGT1A7 protein results in increased glucuronidation of 7-hydroxycoumarin CTD PMID:15502008 NCBI chr 9:88,739,577...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a8 UDP glucuronosyltransferase family 1 member A8 increases glucuronidation EXP UGT1A8 protein results in increased glucuronidation of 7-hydroxycoumarin CTD PMID:15502008 NCBI chr 9:88,727,094...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of 7-hydroxycoumarin CTD PMID:15044611 NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt2b15 UDP glucuronosyltransferase family 2 member B15 increases metabolic processing EXP UGT2B15 protein results in increased metabolism of 7-hydroxycoumarin CTD PMID:7574722 NCBI chr14:20,768,015...20,783,599
Ensembl chr14:20,768,015...20,783,589 		JBrowse link
warfarin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A affects response to substance
increases expression		 ISO ABCB1 polymorphism affects the susceptibility to Warfarin
Warfarin results in increased expression of ABCB1A mRNA		 CTD PMID:24092646 PMID:25312789 PMID:27397090 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcc6 ATP binding cassette subfamily C member 6 multiple interactions
increases response to substance		 ISO [Magnesium deficiency co-treated with Phosphates] promotes the reaction [ABCC6 gene mutant form results in increased susceptibility to Warfarin] CTD PMID:23415960 NCBI chr 1:96,447,224...96,501,464
Ensembl chr 1:96,447,251...96,501,464 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 affects response to substance ISO ABCG2 SNP affects the susceptibility to Warfarin CTD PMID:25300812 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409 		JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP [Warfarin co-treated with Vitamin K co-treated with Quercetin] results in increased expression of ACTA2 mRNA CTD PMID:23117658 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Actb actin, beta increases expression
decreases expression		 ISO Warfarin results in increased expression of ACTB mRNA
Warfarin results in decreased expression of ACTB mRNA		 CTD PMID:20493250 NCBI chr12:11,663,112...11,666,697
Ensembl chr12:11,663,109...11,672,877 		JBrowse link
G Actr3 actin related protein 3 increases expression ISO Warfarin results in increased expression of ACTR3 mRNA CTD PMID:20493250 NCBI chr13:36,800,739...36,843,837
Ensembl chr13:36,800,093...36,844,124 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions
increases expression		 EXP Warfarin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of ADIPOQ protein]
Warfarin results in increased expression of ADIPOQ protein		 CTD PMID:27488359 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a multiple interactions ISO epigallocatechin gallate promotes the reaction [Warfarin inhibits the reaction [Hydrogen Peroxide results in increased expression of AGTR1 mRNA]]; epigallocatechin gallate promotes the reaction [Warfarin inhibits the reaction [Hydrogen Peroxide results in increased expression of AGTR1 protein]]; Warfarin inhibits the reaction [Hydrogen Peroxide results in increased expression of AGTR1 mRNA]; Warfarin inhibits the reaction [Hydrogen Peroxide results in increased expression of AGTR1 protein] CTD PMID:36162953 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946 		JBrowse link
G Ahcy adenosylhomocysteinase decreases expression ISO Warfarin results in decreased expression of AHCY mRNA CTD PMID:20493250 NCBI chr 3:143,569,134...143,584,359
Ensembl chr 3:143,569,094...143,584,393 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP 6-N,N-diethyl-beta,gamma-dibromomethylene-D-ATP inhibits the reaction [[Warfarin co-treated with Phosphates] results in decreased phosphorylation of AKT1 protein]; [Warfarin co-treated with Phosphates] results in decreased phosphorylation of AKT1 protein; [Warfarin co-treated with Vitamin K 1] results in decreased phosphorylation of AKT1 protein; Vitamin K 2 inhibits the reaction [[Warfarin co-treated with Vitamin K 1] results in decreased phosphorylation of AKT1 protein] CTD PMID:22659116 PMID:27212383 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Alb albumin multiple interactions
affects binding
decreases expression		 ISO
EXP		 [Warfarin binds to ALB protein] inhibits the reaction [copper (II) diacetyl-di(N(4)-methylthiosemicarbazone) binds to ALB protein]; [Warfarin binds to ALB protein] inhibits the reaction [copper pyruvaldehyde bis(N(4)-methylthiosemicarbazone) complex binds to ALB protein]; Aspirin inhibits the reaction [Warfarin binds to ALB protein]; prodan inhibits the reaction [Warfarin binds to ALB protein]; Pyruvaldehyde inhibits the reaction [Warfarin binds to ALB protein]
Warfarin results in decreased expression of ALB protein		 CTD PMID:10506189 PMID:12044178 PMID:18937368 PMID:19596536 PMID:20934417 More... NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Alox5ap arachidonate 5-lipoxygenase activating protein increases expression ISO Warfarin results in increased expression of ALOX5AP mRNA CTD PMID:16698924 NCBI chr12:5,748,941...5,772,986
Ensembl chr12:5,748,944...5,772,986 		JBrowse link
G Alpl alkaline phosphatase, biomineralization associated multiple interactions ISO Warfarin inhibits the reaction [BMP2 protein results in increased activity of ALPL protein]; Warfarin inhibits the reaction [BMP2 protein results in increased expression of ALPL mRNA]; Warfarin inhibits the reaction [RUNX2 protein results in increased expression of ALPL mRNA] CTD PMID:21910061 NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446 		JBrowse link
G Anxa4 annexin A4 decreases expression ISO Warfarin results in decreased expression of ANXA4 mRNA CTD PMID:20493250 NCBI chr 4:119,184,378...119,241,183
Ensembl chr 4:119,184,374...119,241,161 		JBrowse link
G Anxa5 annexin A5 decreases expression ISO Warfarin results in decreased expression of ANXA5 mRNA CTD PMID:20493250 NCBI chr 2:119,314,007...119,344,703
Ensembl chr 2:119,314,007...119,353,369 		JBrowse link
G Apoa1 apolipoprotein A1 affects response to substance ISO APOA1 gene SNP affects the susceptibility to Warfarin CTD PMID:32282500 NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035 		JBrowse link
G Apob apolipoprotein B affects response to substance ISO APOB gene SNP affects the susceptibility to Warfarin CTD PMID:31186542 NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497 		JBrowse link
G Apoe apolipoprotein E increases response to substance
affects response to substance		 ISO APOE gene mutant form results in increased susceptibility to Warfarin
APOE gene mutant form affects the susceptibility to Warfarin; APOE gene polymorphism affects the susceptibility to Warfarin; APOE gene SNP affects the susceptibility to Warfarin; APOE polymorphism affects the susceptibility to Warfarin; APOE protein affects the susceptibility to Warfarin; APOE SNP affects the susceptibility to Warfarin		 CTD PMID:15952022 PMID:16847429 PMID:17048007 PMID:17325732 PMID:21228733 More... NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932 		JBrowse link
G Arhgdia Rho GDP dissociation inhibitor alpha increases expression ISO Warfarin results in increased expression of ARHGDIA mRNA CTD PMID:20493250 NCBI chr10:105,854,526...105,858,020
Ensembl chr10:105,854,533...105,858,023 		JBrowse link
G Arsl arylsulfatase L decreases activity ISO Warfarin results in decreased activity of ARSL protein CTD PMID:7720070 NCBI chr 2:119,038,803...119,047,579
Ensembl chr 2:119,038,921...119,046,846 		JBrowse link
G Asph aspartate-beta-hydroxylase affects response to substance ISO ASPH gene SNP affects the susceptibility to Warfarin CTD PMID:27488176 NCBI chr 5:22,601,581...22,814,107
Ensembl chr 5:22,603,486...22,813,876 		JBrowse link
G Axin2 axin 2 multiple interactions
increases expression		 EXP [Warfarin co-treated with Vitamin K] results in increased expression of AXIN2 mRNA; Quercetin inhibits the reaction [[Warfarin co-treated with Vitamin K] results in increased expression of AXIN2 mRNA]; Quercetin inhibits the reaction [Warfarin results in increased expression of AXIN2 mRNA] CTD PMID:23117658 NCBI chr10:93,893,830...93,927,042
Ensembl chr10:93,899,245...93,926,231 		JBrowse link
G Axl Axl receptor tyrosine kinase multiple interactions
decreases phosphorylation
increases response to substance
decreases expression		 EXP
ISO		 [Warfarin co-treated with Vitamin K 1] results in decreased expression of AXL protein; Vitamin K 2 inhibits the reaction [[Warfarin co-treated with Vitamin K 1] results in decreased expression of AXL protein]; Warfarin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of AXL protein]
Warfarin results in decreased phosphorylation of AXL protein
AXL protein results in increased susceptibility to Warfarin
AXL protein promotes the reaction [Warfarin results in increased susceptibility to Gemcitabine]; Vitamin K inhibits the reaction [Warfarin results in decreased expression of AXL protein modified form]; Warfarin inhibits the reaction [GAS6 protein results in increased activity of AXL protein]
Warfarin results in decreased expression of AXL protein; Warfarin results in decreased expression of AXL protein modified form		 CTD PMID:15123721 PMID:26206560 PMID:27212383 NCBI chr 1:81,265,088...81,296,278
Ensembl chr 1:81,265,088...81,296,265 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP [Warfarin co-treated with Vitamin K 1] results in decreased expression of BCL2 protein; Vitamin K 2 inhibits the reaction [[Warfarin co-treated with Vitamin K 1] results in decreased expression of BCL2 protein] CTD PMID:27212383 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bglap bone gamma-carboxyglutamate protein multiple interactions
increases expression		 ISO
EXP		 Warfarin inhibits the reaction [BMP2 protein results in increased activity of BGLAP protein]; Warfarin inhibits the reaction [BMP2 protein results in increased expression of BGLAP mRNA]; Warfarin inhibits the reaction [menaquinone 7 results in increased carboxylation of BGLAP protein]; Warfarin inhibits the reaction [menatetrenone results in increased carboxylation of BGLAP protein]; Warfarin inhibits the reaction [RUNX2 protein results in increased expression of BGLAP mRNA]; Warfarin inhibits the reaction [Vitamin K 1 results in increased carboxylation of BGLAP protein]
Warfarin results in increased expression of BGLAP mRNA; Warfarin results in increased expression of BGLAP protein modified form
[Warfarin co-treated with Vitamin K] results in increased expression of BGLAP mRNA; Quercetin inhibits the reaction [[Warfarin co-treated with Vitamin K] results in increased expression of BGLAP mRNA]; Quercetin inhibits the reaction [Warfarin results in increased expression of BGLAP mRNA]; Warfarin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of BGLAP protein modified form]		 CTD PMID:21910061 PMID:23117658 PMID:23223575 PMID:27488359 PMID:31173816 NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495 		JBrowse link
G Bmp2 bone morphogenetic protein 2 multiple interactions ISO
EXP		 Warfarin inhibits the reaction [BMP2 protein results in increased activity of ALPL protein]; Warfarin inhibits the reaction [BMP2 protein results in increased activity of BGLAP protein]; Warfarin inhibits the reaction [BMP2 protein results in increased activity of RUNX2 protein]; Warfarin inhibits the reaction [BMP2 protein results in increased expression of ALPL mRNA]; Warfarin inhibits the reaction [BMP2 protein results in increased expression of BGLAP mRNA]; Warfarin inhibits the reaction [BMP2 protein results in increased expression of COL1A1 mRNA]; Warfarin inhibits the reaction [BMP2 protein results in increased expression of SP7 mRNA]
[Warfarin co-treated with Vitamin K 1] affects the expression of BMP2 mRNA; [Warfarin co-treated with Vitamin K 1] affects the expression of BMP2 protein; Losartan affects the reaction [[Warfarin co-treated with Vitamin K 1] affects the expression of BMP2 mRNA]; Losartan affects the reaction [[Warfarin co-treated with Vitamin K 1] affects the expression of BMP2 protein]		 CTD PMID:21910061 PMID:27412937 NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397 		JBrowse link
G C1qbp complement C1q binding protein increases expression ISO Warfarin results in increased expression of C1QBP mRNA CTD PMID:20493250 NCBI chr10:55,699,954...55,704,605
Ensembl chr10:55,699,954...55,704,649 		JBrowse link
G Calr calreticulin increases expression ISO Warfarin results in increased expression of CALR mRNA CTD PMID:20493250 NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414 		JBrowse link
G Calu calumenin decreases response to substance
affects response to substance		 EXP
ISO		 CALU protein results in decreased susceptibility to Warfarin
CALU gene SNP affects the susceptibility to Warfarin; CALU polymorphism affects the susceptibility to Warfarin		 CTD PMID:11641264 PMID:20200517 PMID:27632229 NCBI chr 4:57,949,086...57,976,589
Ensembl chr 4:57,948,997...57,976,593 		JBrowse link
G Casp3 caspase 3 decreases expression
increases expression
multiple interactions		 ISO
EXP		 Warfarin results in decreased expression of CASP3 mRNA
Warfarin results in increased expression of CASP3 protein modified form
[Warfarin co-treated with Vitamin K 1] results in increased cleavage of CASP3 protein
Warfarin results in increased expression of CASP3 mRNA		 CTD PMID:19815060 PMID:20493250 PMID:23990204 PMID:26206560 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cat catalase increases activity EXP Warfarin results in increased activity of CAT protein CTD PMID:22342526 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccnd1 cyclin D1 increases expression
multiple interactions		 EXP Warfarin results in increased expression of CCND1 mRNA
[Warfarin co-treated with Vitamin K] results in increased expression of CCND1 mRNA; Quercetin inhibits the reaction [[Warfarin co-treated with Vitamin K] results in increased expression of CCND1 mRNA]; Quercetin inhibits the reaction [Warfarin results in increased expression of CCND1 mRNA]		 CTD PMID:23117658 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cct5 chaperonin containing TCP1 subunit 5 increases expression ISO Warfarin results in increased expression of CCT5 mRNA CTD PMID:20493250 NCBI chr 2:82,591,750...82,602,903
Ensembl chr 2:82,590,630...82,602,930 		JBrowse link
G Cct6a chaperonin containing TCP1 subunit 6A increases expression ISO Warfarin results in increased expression of CCT6A mRNA CTD PMID:20493250 NCBI chr12:26,872,736...26,883,125
Ensembl chr12:26,872,574...26,883,337 		JBrowse link
G Cct8 chaperonin containing TCP1 subunit 8 decreases expression ISO Warfarin results in decreased expression of CCT8 mRNA CTD PMID:20493250 NCBI chr11:26,710,370...26,722,079
Ensembl chr11:26,710,370...26,722,079 		JBrowse link
G Cdc42 cell division cycle 42 decreases expression ISO Warfarin results in decreased expression of CDC42 mRNA CTD PMID:20493250 NCBI chr 5:149,555,069...149,593,239
Ensembl chr 5:149,553,724...149,593,111 		JBrowse link
G Cdh1 cadherin 1 increases expression ISO Warfarin results in increased expression of CDH1 protein CTD PMID:26206560 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Clic1 chloride intracellular channel 1 decreases expression ISO Warfarin results in decreased expression of CLIC1 mRNA CTD PMID:20493250 NCBI chr20:3,764,867...3,773,711
Ensembl chr20:3,761,461...3,773,712 		JBrowse link
G Cnn1 calponin 1 multiple interactions EXP [Warfarin co-treated with Vitamin K co-treated with Quercetin] results in increased expression of CNN1 mRNA CTD PMID:23117658 NCBI chr 8:20,632,434...20,641,097
Ensembl chr 8:20,632,338...20,641,098 		JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions
increases expression		 ISO
EXP		 Warfarin inhibits the reaction [BMP2 protein results in increased expression of COL1A1 mRNA]
[Warfarin co-treated with Vitamin K] results in increased expression of COL1A1 mRNA; Quercetin inhibits the reaction [[Warfarin co-treated with Vitamin K] results in increased expression of COL1A1 mRNA]; Quercetin inhibits the reaction [Warfarin results in increased expression of COL1A1 mRNA]		 CTD PMID:21910061 PMID:23117658 PMID:23223575 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Cox15 cytochrome c oxidase assembly homolog COX15 affects response to substance ISO COX15 gene affects the susceptibility to Warfarin CTD PMID:28686080 NCBI chr 1:242,605,588...242,622,279
Ensembl chr 1:242,605,588...242,622,261 		JBrowse link
G Cox5a cytochrome c oxidase subunit 5A increases expression ISO Warfarin results in increased expression of COX5A mRNA CTD PMID:20493250 NCBI chr 8:57,922,374...57,933,781
Ensembl chr 8:57,922,290...57,933,781 		JBrowse link
G Crk CRK proto-oncogene, adaptor protein increases expression ISO Warfarin results in increased expression of CRK mRNA CTD PMID:20493250 NCBI chr10:60,530,469...60,556,703
Ensembl chr10:60,530,464...60,553,406 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
affects response to substance		 ISO
EXP		 Warfarin results in decreased expression of and affects the localization of CTNNB1 protein
CTNNB1 protein affects the susceptibility to Warfarin
Quercetin inhibits the reaction [Warfarin results in increased expression of and affects the localization of CTNNB1 protein]; Warfarin results in increased expression of and affects the localization of CTNNB1 protein		 CTD PMID:23117658 PMID:23223575 PMID:26206560 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity ISO Warfarin results in decreased activity of CYP1A1 protein CTD PMID:18420780 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 affects metabolic processing
affects response to substance		 ISO CYP1A2 protein affects the metabolism of Warfarin
CYP1A2 SNP affects the susceptibility to Warfarin		 CTD PMID:14676821 PMID:15280511 PMID:28079798 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp2a3 cytochrome P450, family 2, subfamily a, polypeptide 3 decreases activity ISO Warfarin results in decreased activity of CYP2A4 protein CTD PMID:18420780 NCBI chr 1:82,171,914...82,179,980
Ensembl chr 1:82,169,949...82,179,979 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 decreases activity ISO Warfarin results in decreased activity of CYP2B10 protein CTD PMID:18420780 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 increases metabolic processing
affects response to substance		 EXP
ISO		 CYP2C11 protein results in increased metabolism of Warfarin
CYP2C18 gene polymorphism affects the susceptibility to Warfarin; CYP2C18 protein affects the susceptibility to Warfarin		 CTD PMID:19752777 PMID:30724651 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066 		JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 affects response to substance
decreases activity
affects metabolic processing
multiple interactions		 ISO CYP2C19 gene polymorphism affects the susceptibility to Warfarin; CYP2C19 polymorphism affects the susceptibility to Warfarin; CYP2C19 protein affects the susceptibility to Warfarin
Warfarin results in decreased activity of CYP2C29 protein
CYP2C19 protein affects the metabolism of Warfarin
CYP2C19 gene polymorphism affects the metabolism of and affects the susceptibility to Warfarin; Omeprazole affects the reaction [CYP2C19 protein affects the metabolism of Warfarin]		 CTD PMID:18420780 PMID:18520598 PMID:19752777 PMID:25652102 PMID:27356304 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 affects response to substance ISO CYP2C8 polymorphism affects the susceptibility to Warfarin CTD PMID:34382722
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases activity ISO Warfarin results in decreased activity of CYP2D6 protein CTD PMID:18420780 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression
affects hydroxylation
multiple interactions
decreases expression
affects metabolic processing
affects response to substance
decreases activity		 EXP
ISO		 Warfarin results in increased expression of CYP3A2 mRNA
CYP3A4 protein affects the hydroxylation of Warfarin
[Warfarin binds to and results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA
Warfarin results in decreased expression of CYP3A4 mRNA
CYP3A4 protein affects the metabolism of Warfarin
CYP3A4 SNP affects the susceptibility to Warfarin
Warfarin results in decreased activity of CYP3A4 protein
CYP3A2 mRNA affects the susceptibility to Warfarin		 CTD PMID:2271712 PMID:11531004 PMID:15280511 PMID:16035367 PMID:18420780 More... NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 affects response to substance ISO CYP3A5 gene polymorphism affects the susceptibility to Warfarin; CYP3A5 polymorphism affects the susceptibility to Warfarin; CYP3A5 protein affects the susceptibility to Warfarin CTD PMID:19752777 PMID:34382722 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422 		JBrowse link
G Dctn2 dynactin subunit 2 decreases expression ISO Warfarin results in decreased expression of DCTN2 mRNA CTD PMID:20493250 NCBI chr 7:63,092,061...63,107,560
Ensembl chr 7:63,092,057...63,108,543 		JBrowse link
G Ddhd1 DDHD domain containing 1 affects response to substance ISO DDHD1 gene SNP affects the susceptibility to Warfarin CTD PMID:27488176 NCBI chr15:18,824,389...18,891,036
Ensembl chr15:18,824,394...18,890,952 		JBrowse link
G Ddt D-dopachrome tautomerase decreases expression ISO Warfarin results in decreased expression of DDT mRNA CTD PMID:20493250 NCBI chr20:12,884,216...12,886,687
Ensembl chr20:12,884,243...12,888,482 		JBrowse link
G Dlst dihydrolipoamide S-succinyltransferase decreases expression ISO Warfarin results in decreased expression of DLST mRNA CTD PMID:20493250 NCBI chr 6:104,758,511...104,783,296
Ensembl chr 6:104,758,631...104,783,296 		JBrowse link
G Dock7 dedicator of cytokinesis 7 increases expression ISO Warfarin results in increased expression of DOCK7 mRNA CTD PMID:20493250 NCBI chr 5:113,599,371...113,782,871
Ensembl chr 5:113,600,198...113,782,813 		JBrowse link
G Dpysl2 dihydropyrimidinase-like 2 increases expression ISO Warfarin results in increased expression of DPYSL2 mRNA CTD PMID:20493250 NCBI chr15:41,005,551...41,111,724
Ensembl chr15:41,005,551...41,111,829 		JBrowse link
G Dstn destrin, actin depolymerizing factor decreases expression ISO Warfarin results in decreased expression of DSTN mRNA CTD PMID:20493250 NCBI chr 3:131,284,647...131,311,361
Ensembl chr 3:131,284,648...131,311,379 		JBrowse link
G Eef2 eukaryotic translation elongation factor 2 decreases expression ISO Warfarin results in decreased expression of EEF2 mRNA CTD PMID:20493250 NCBI chr 7:8,533,248...8,538,518
Ensembl chr 7:8,533,116...8,559,183 		JBrowse link
G Eif3i eukaryotic translation initiation factor 3, subunit I decreases expression ISO Warfarin results in decreased expression of EIF3I mRNA CTD PMID:20493250 NCBI chr 5:141,935,135...141,942,589
Ensembl chr 5:141,935,044...141,942,676 		JBrowse link
G Emcn endomucin decreases expression ISO Warfarin results in decreased expression of EMCN protein CTD PMID:26206560 NCBI chr 2:225,891,100...225,970,932
Ensembl chr 2:225,891,100...225,970,929 		JBrowse link
G Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 increases expression EXP Warfarin results in increased expression of ENPP1 mRNA; Warfarin results in increased expression of ENPP1 protein CTD PMID:22659116 NCBI chr 1:20,698,746...20,763,741
Ensembl chr 1:20,698,764...20,763,715 		JBrowse link
G Epha7 Eph receptor A7 affects response to substance ISO EPHA7 promoter SNP affects the susceptibility to Warfarin CTD PMID:30357299 NCBI chr 5:42,975,353...43,128,703
Ensembl chr 5:42,975,405...43,127,112 		JBrowse link
G Ephx1 epoxide hydrolase 1 increases response to substance
affects response to substance		 ISO EPHX1 protein results in increased susceptibility to Warfarin
EPHX1 gene polymorphism affects the susceptibility to Warfarin; EPHX1 gene SNP affects the susceptibility to Warfarin; EPHX1 intron SNP affects the susceptibility to Warfarin; EPHX1 polymorphism affects the susceptibility to Warfarin; EPHX1 SNP affects the susceptibility to Warfarin		 CTD PMID:15900282 PMID:17496169 PMID:20842355 PMID:21192345 PMID:24092646 More... NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235 		JBrowse link
G Erp29 endoplasmic reticulum protein 29 decreases expression ISO Warfarin results in decreased expression of ERP29 mRNA CTD PMID:20493250 NCBI chr12:35,089,698...35,095,952
Ensembl chr12:35,089,707...35,096,376 		JBrowse link
G F10 coagulation factor X decreases activity EXP Warfarin results in decreased activity of F10 protein CTD PMID:3490277 PMID:20371969 NCBI chr16:76,468,834...76,488,141
Ensembl chr16:76,468,838...76,488,141 		JBrowse link
G F2 coagulation factor II, thrombin multiple interactions
decreases activity
decreases expression
affects response to substance		 ISO
EXP		 Fenofibrate promotes the reaction [Warfarin results in decreased expression of F2 protein]
Warfarin results in decreased activity of F2 protein
F2 gene polymorphism affects the susceptibility to Warfarin		 CTD PMID:3490277 PMID:9681093 PMID:14656880 NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486 		JBrowse link
G F5 coagulation factor V affects response to substance
decreases activity		 ISO
EXP		 F5 gene polymorphism affects the susceptibility to Warfarin; F5 protein affects the susceptibility to Warfarin
Warfarin results in decreased activity of F5 protein		 CTD PMID:3490277 PMID:19752777 NCBI chr13:76,513,509...76,583,106
Ensembl chr13:76,513,255...76,582,317 		JBrowse link
G F7 coagulation factor VII affects response to substance
decreases activity
multiple interactions
decreases expression		 ISO
EXP		 F7 gene mutant form affects the susceptibility to Warfarin; F7 gene polymorphism affects the susceptibility to Warfarin
Warfarin results in decreased activity of F7 protein
Fenofibrate promotes the reaction [Warfarin results in decreased expression of F7 protein]		 CTD PMID:3490277 PMID:9681093 PMID:14656880 PMID:20371969 PMID:20885134 NCBI chr16:76,489,775...76,500,636
Ensembl chr16:76,489,717...76,500,610 		JBrowse link
G F9 coagulation factor IX decreases activity
increases response to substance		 EXP
ISO		 Warfarin results in decreased activity of F9 protein
F9 gene alternative form results in increased susceptibility to Warfarin		 CTD PMID:3490277 PMID:29450643 NCBI chr  X:138,352,334...138,396,835
Ensembl chr  X:138,352,298...138,396,835 		JBrowse link
G Fabp1 fatty acid binding protein 1 multiple interactions EXP Warfarin inhibits the reaction [3-(p-azidobenzyl)-4-hydroxycoumarin binds to Fabp1 protein] RGD PMID:1939124 RGD:1626448 NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788 		JBrowse link
G Fgf5 fibroblast growth factor 5 affects response to substance ISO FGF5 gene affects the susceptibility to Warfarin CTD PMID:28686080 NCBI chr14:11,323,827...11,346,164
Ensembl chr14:11,325,334...11,345,997 		JBrowse link
G Fpgs folylpolyglutamate synthase affects response to substance ISO FPGS gene polymorphism affects the susceptibility to Warfarin CTD PMID:25079360 NCBI chr 3:15,972,800...15,993,592
Ensembl chr 3:15,972,800...15,993,563 		JBrowse link
G Fscn1 fascin actin-bundling protein 1 decreases expression ISO Warfarin results in decreased expression of FSCN1 mRNA CTD PMID:20493250 NCBI chr12:11,597,042...11,610,183
Ensembl chr12:11,597,048...11,610,211 		JBrowse link
G G3bp1 G3BP stress granule assembly factor 1 increases expression ISO Warfarin results in increased expression of G3BP1 mRNA CTD PMID:20493250 NCBI chr10:39,586,864...39,620,268
Ensembl chr10:39,586,864...39,620,268 		JBrowse link
G Gal3st1 galactose-3-O-sulfotransferase 1 increases expression ISO Warfarin results in increased expression of GAL3ST1 mRNA CTD PMID:27397090 NCBI chr14:78,868,049...78,886,402
Ensembl chr14:78,870,793...78,886,388 		JBrowse link
G Gale UDP-galactose-4-epimerase decreases expression ISO Warfarin results in decreased expression of GALE mRNA CTD PMID:20493250 NCBI chr 5:148,193,886...148,198,392
Ensembl chr 5:148,194,791...148,198,388 		JBrowse link
G Gas6 growth arrest specific 6 decreases expression
multiple interactions
decreases carboxylation		 EXP
ISO		 Warfarin results in decreased expression of GAS6 protein
Warfarin inhibits the reaction [GAS6 protein results in increased activity of AXL protein]
Warfarin results in decreased carboxylation of GAS6 protein
[Warfarin co-treated with Vitamin K 1] results in decreased expression of GAS6 protein; Vitamin K 2 inhibits the reaction [[Warfarin co-treated with Vitamin K 1] results in decreased expression of GAS6 protein]; Warfarin results in decreased activity of and results in decreased carboxylation of GAS6 protein		 CTD PMID:9163328 PMID:19564549 PMID:26206560 PMID:27212383 NCBI chr16:76,045,430...76,075,904
Ensembl chr16:76,045,426...76,075,904 		JBrowse link
G Gata4 GATA binding protein 4 affects response to substance ISO GATA4 gene SNP affects the susceptibility to Warfarin CTD PMID:31190750 NCBI chr15:37,459,601...37,531,291
Ensembl chr15:37,459,601...37,505,636 		JBrowse link
G Gata6 GATA binding protein 6 affects response to substance ISO GATA6 gene SNP affects the susceptibility to Warfarin CTD PMID:31190750 NCBI chr18:2,188,121...2,219,532
Ensembl chr18:2,188,121...2,219,532 		JBrowse link
G Gdi2 GDP dissociation inhibitor 2 increases expression ISO Warfarin results in increased expression of GDI2 mRNA CTD PMID:20493250 NCBI chr17:66,649,616...66,676,299
Ensembl chr17:66,649,619...66,676,366 		JBrowse link
G Gfap glial fibrillary acidic protein increases expression ISO Warfarin results in increased expression of GFAP mRNA; Warfarin results in increased expression of GFAP protein CTD PMID:27397090 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589 		JBrowse link
G Ggcx gamma-glutamyl carboxylase affects response to substance
increases activity
increases response to substance
decreases response to substance		 ISO
EXP		 GGCX gene polymorphism affects the susceptibility to Warfarin; GGCX gene SNP affects the susceptibility to Warfarin; GGCX polymorphism affects the susceptibility to Warfarin
Warfarin results in increased activity of GGCX protein
GGCX protein results in increased susceptibility to Warfarin
GGCX gene polymorphism results in decreased susceptibility to Warfarin		 CTD PMID:3490277 PMID:16676068 PMID:17049586 PMID:17496169 PMID:17764537 More... NCBI chr 4:104,469,737...104,485,631
Ensembl chr 4:104,469,765...104,487,063 		JBrowse link
G Gmps guanine monophosphate synthase increases expression ISO Warfarin results in increased expression of GMPS mRNA CTD PMID:20493250 NCBI chr 2:148,441,369...148,491,908
Ensembl chr 2:148,435,643...148,485,875 		JBrowse link
G Gprc6a G protein-coupled receptor, class C, group 6, member A multiple interactions EXP Warfarin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of GPRC6A mRNA] CTD PMID:27488359 NCBI chr20:30,922,106...30,943,412
Ensembl chr20:30,922,106...30,943,412 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions EXP [Warfarin co-treated with Vitamin K] results in increased phosphorylation of GSK3B protein; Quercetin inhibits the reaction [[Warfarin co-treated with Vitamin K] results in increased phosphorylation of GSK3B protein] CTD PMID:23117658 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Hdac1 histone deacetylase 1 increases expression ISO Warfarin results in increased expression of HDAC1 mRNA CTD PMID:20493250 NCBI chr 5:141,853,992...141,881,057
Ensembl chr 5:141,853,989...141,881,111 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO epigallocatechin gallate promotes the reaction [Warfarin inhibits the reaction [Hydrogen Peroxide results in increased expression of HIF1A protein]]; Warfarin inhibits the reaction [Hydrogen Peroxide results in increased expression of HIF1A protein] CTD PMID:36162953 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hint1 histidine triad nucleotide binding protein 1 increases expression ISO Warfarin results in increased expression of HINT1 mRNA CTD PMID:20493250 NCBI chr10:38,989,516...38,993,259
Ensembl chr 4:92,100,973...92,101,568 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions EXP Warfarin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of HMGCR mRNA] CTD PMID:27488359 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703 		JBrowse link
G Hmox1 heme oxygenase 1 affects expression EXP Warfarin affects the expression of HMOX1 mRNA CTD PMID:22954530 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hnrnpab heterogeneous nuclear ribonucleoprotein A/B increases expression ISO Warfarin results in increased expression of HNRNPAB mRNA CTD PMID:20493250 NCBI chr10:35,857,040...35,862,935
Ensembl chr10:35,857,041...35,863,344 		JBrowse link
G Hnrnpdl heterogeneous nuclear ribonucleoprotein D-like decreases expression ISO Warfarin results in decreased expression of HNRNPDL mRNA CTD PMID:20493250 NCBI chr14:9,557,430...9,563,659
Ensembl chr14:9,557,425...9,562,506 		JBrowse link
G Hnrnpf heterogeneous nuclear ribonucleoprotein F increases expression ISO Warfarin results in increased expression of HNRNPF mRNA CTD PMID:20493250 NCBI chr 4:151,083,262...151,104,464
Ensembl chr 4:151,083,062...151,109,038 		JBrowse link
G Hnrnpk heterogeneous nuclear ribonucleoprotein K increases expression
decreases expression		 ISO Warfarin results in increased expression of HNRNPK mRNA
Warfarin results in decreased expression of HNRNPK mRNA		 CTD PMID:20493250 NCBI chr17:6,262,936...6,275,001
Ensembl chr17:6,262,998...6,274,997 		JBrowse link
G Hp haptoglobin increases expression EXP Warfarin results in increased expression of HP protein CTD PMID:22342526 NCBI chr19:37,539,626...37,544,178
Ensembl chr19:37,539,627...37,544,523 		JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 decreases expression ISO Warfarin results in decreased expression of HSP90AB1 mRNA CTD PMID:20493250 NCBI chr 9:15,432,986...15,438,358
Ensembl chr 9:15,433,691...15,438,488 		JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 increases expression ISO Warfarin results in increased expression of HSPA8 mRNA CTD PMID:20493250 NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259 		JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 increases expression ISO Warfarin results in increased expression of HSPD1 mRNA CTD PMID:20493250 NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662 		JBrowse link
G Il12a interleukin 12A increases expression EXP Warfarin results in increased expression of IL12A mRNA CTD PMID:22342526 NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734 		JBrowse link
G Il12b interleukin 12B increases expression EXP Warfarin results in increased expression of IL12B mRNA CTD PMID:22342526 NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases expression		 ISO
EXP		 Warfarin inhibits the reaction [Vitamin K 2 results in decreased susceptibility to IL1B protein]
Warfarin results in decreased expression of IL1B mRNA
[Warfarin co-treated with Vitamin K] results in increased expression of IL1B mRNA		 CTD PMID:20460758 PMID:23117658 PMID:29594315 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il2 interleukin 2 multiple interactions ISO [Warfarin co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IL2 mRNA CTD PMID:29594315 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions
decreases expression
decreases secretion		 EXP
ISO		 Warfarin results in increased expression of IL6 protein
[Warfarin co-treated with Vitamin K] results in increased expression of IL6 mRNA
Warfarin results in decreased expression of IL6 mRNA
Warfarin results in decreased secretion of IL6 protein
Warfarin results in decreased expression of IL6 protein		 CTD PMID:18772604 PMID:22342526 PMID:23117658 PMID:26742017 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Ins1 insulin 1 increases secretion
multiple interactions		 EXP Warfarin results in increased secretion of INS1 protein
Warfarin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased secretion of INS1 protein]		 CTD PMID:27488359 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536 		JBrowse link
G Ipo5 importin 5 decreases expression ISO Warfarin results in decreased expression of IPO5 mRNA CTD PMID:20493250 NCBI chr15:97,990,755...98,041,074
Ensembl chr15:98,005,299...98,041,126 		JBrowse link
G Isyna1 inositol-3-phosphate synthase 1 increases expression ISO Warfarin results in increased expression of ISYNA1 mRNA CTD PMID:20493250 NCBI chr16:18,839,143...18,841,979
Ensembl chr16:18,839,145...18,841,979 		JBrowse link
G Krt18 keratin 18 decreases expression ISO Warfarin results in decreased expression of KRT18 mRNA CTD PMID:20493250 NCBI chr 7:133,157,486...133,161,162
Ensembl chr 7:133,157,475...133,161,166 		JBrowse link
G Lasp1 LIM and SH3 protein 1 decreases expression ISO Warfarin results in decreased expression of LASP1 mRNA CTD PMID:20493250 NCBI chr10:82,795,177...82,835,659
Ensembl chr10:82,795,137...82,943,292 		JBrowse link
G Lrp1 LDL receptor related protein 1 affects response to substance ISO LRP1 gene SNP affects the susceptibility to Warfarin CTD PMID:32282500 NCBI chr 7:63,380,325...63,461,029
Ensembl chr 7:63,380,356...63,460,910 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO epigallocatechin gallate promotes the reaction [Warfarin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein]]; Warfarin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein] CTD PMID:36162953 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO epigallocatechin gallate promotes the reaction [Warfarin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein]]; Warfarin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein] CTD PMID:36162953 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mgp matrix Gla protein multiple interactions
decreases carboxylation		 ISO
EXP		 [[Warfarin co-treated with Vitamin K 1] results in decreased carboxylation of MGP protein] which results in decreased activity of MGP protein; [Warfarin co-treated with Vitamin K 1] results in decreased activity of MGP protein; [Warfarin co-treated with Vitamin K 1] results in decreased carboxylation of MGP protein; [Warfarin co-treated with Vitamin K 1] results in decreased expression of MGP mRNA
Warfarin results in decreased carboxylation of MGP protein
[Quercetin co-treated with Warfarin] results in decreased carboxylation of MGP protein; [Vitamin K co-treated with Warfarin] results in increased carboxylation of MGP protein; Warfarin inhibits the reaction [Vitamin K 1 results in increased expression of and results in increased secretion of MGP protein modified form]; Warfarin results in decreased expression of and results in decreased secretion of MGP protein; Warfarin results in decreased expression of and results in decreased secretion of MGP protein modified form		 CTD PMID:21705322 PMID:23223575 PMID:23990204 NCBI chr 4:169,766,290...169,769,612
Ensembl chr 4:169,766,279...169,769,667 		JBrowse link
G Mir3582 microRNA 3582 affects response to substance ISO MIR133A2 gene SNP affects the susceptibility to Warfarin CTD PMID:26113018 NCBI chr18:1,885,063...1,885,180
Ensembl chr18:1,885,063...1,885,180 		JBrowse link
G Mpo myeloperoxidase increases activity EXP Warfarin results in increased activity of MPO protein CTD PMID:26742017 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Myh1 myosin heavy chain 1 multiple interactions EXP [Warfarin co-treated with Vitamin K co-treated with Quercetin] results in increased expression of MYH1 mRNA CTD PMID:23117658 NCBI chr10:51,885,913...51,909,699
Ensembl chr10:51,885,913...51,946,295 		JBrowse link
G Myh6 myosin heavy chain 6 affects response to substance ISO MYH6 polymorphism affects the susceptibility to Warfarin CTD PMID:34515533 NCBI chr15:28,418,120...28,442,316
Ensembl chr15:28,417,616...28,441,720 		JBrowse link
G Nedd4 NEDD4 E3 ubiquitin protein ligase affects response to substance ISO NEDD4 gene SNP affects the susceptibility to Warfarin CTD PMID:27488176 NCBI chr 8:73,384,095...73,468,951
Ensembl chr 8:73,383,695...73,468,951 		JBrowse link
G Nmral1 NmrA like redox sensor 1 increases expression ISO Warfarin results in increased expression of NMRAL1 mRNA CTD PMID:20493250 NCBI chr10:10,841,693...10,850,199
Ensembl chr10:10,841,799...10,850,192 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 affects response to substance ISO NQO1 gene SNP affects the susceptibility to Warfarin; NQO1 polymorphism affects the susceptibility to Warfarin CTD PMID:23215885 PMID:26257249 PMID:27581200 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
decreases expression		 ISO [Warfarin binds to and results in increased activity of NR1I2 protein] which results in increased expression of CYP2C9 mRNA; [Warfarin binds to and results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; Warfarin binds to and results in increased activity of NR1I2 protein
Warfarin results in decreased expression of NR1I2 mRNA		 CTD PMID:20735727 PMID:30963258 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Nucb1 nucleobindin 1 increases expression ISO Warfarin results in increased expression of NUCB1 mRNA CTD PMID:20493250 NCBI chr 1:95,968,325...95,999,183
Ensembl chr 1:95,968,326...96,003,220 		JBrowse link
G Numb NUMB, endocytic adaptor protein multiple interactions EXP [Warfarin co-treated with Vitamin K] results in increased expression of NUMB mRNA; Quercetin inhibits the reaction [[Warfarin co-treated with Vitamin K] results in increased expression of NUMB mRNA] CTD PMID:23117658 NCBI chr 6:103,431,400...103,553,422
Ensembl chr 6:103,431,400...103,553,354 		JBrowse link
G Oat ornithine aminotransferase decreases expression ISO Warfarin results in decreased expression of OAT mRNA CTD PMID:20493250 NCBI chr 1:187,347,862...187,367,644
Ensembl chr 1:187,347,865...187,367,682 		JBrowse link
G Orm1 orosomucoid 1 multiple interactions
affects binding
increases response to substance
affects response to substance		 ISO Chlorpromazine inhibits the reaction [Warfarin binds to ORM1 protein alternative form]; Dipyridamole inhibits the reaction [Warfarin binds to ORM1 protein alternative form]; Lidocaine inhibits the reaction [Warfarin binds to ORM1 protein alternative form]; Progesterone inhibits the reaction [Warfarin binds to ORM1 protein alternative form]
ORM1 protein results in increased susceptibility to Warfarin
ORM1 gene polymorphism affects the susceptibility to Warfarin; ORM1 polymorphism affects the susceptibility to Warfarin		 CTD PMID:8946472 PMID:17496169 PMID:23208322 PMID:26644206 NCBI chr 5:76,766,637...76,776,149
Ensembl chr 5:76,772,941...76,776,154 		JBrowse link
G Pa2g4 proliferation-associated 2G4 increases expression ISO Warfarin results in increased expression of PA2G4 mRNA CTD PMID:20493250 NCBI chr 7:984,795...992,264
Ensembl chr 7:983,971...992,331 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases expression ISO Warfarin results in increased expression of PARP1 protein modified form CTD PMID:26206560 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pdgfb platelet derived growth factor subunit B decreases expression EXP Warfarin results in decreased expression of PDGFB mRNA; Warfarin results in decreased expression of PDGFB protein CTD PMID:11290560 NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984 		JBrowse link
G Pdia3 protein disulfide isomerase family A, member 3 increases expression
decreases expression		 ISO Warfarin results in increased expression of PDIA3 mRNA
Warfarin results in decreased expression of PDIA3 mRNA		 CTD PMID:20493250 NCBI chr 3:108,388,189...108,412,013
Ensembl chr 3:108,388,245...108,413,236 		JBrowse link
G Pdia4 protein disulfide isomerase family A, member 4 decreases expression ISO Warfarin results in decreased expression of PDIA4 mRNA CTD PMID:20493250 NCBI chr 4:76,803,198...76,822,245
Ensembl chr 4:76,803,198...76,822,107 		JBrowse link
G Pgam1 phosphoglycerate mutase 1 decreases expression
increases expression		 ISO Warfarin results in decreased expression of PGAM1 mRNA
Warfarin results in increased expression of PGAM1 mRNA		 CTD PMID:20493250 NCBI chr 1:240,723,832...240,731,443
Ensembl chr 1:240,723,920...240,738,452 		JBrowse link
G Pkm pyruvate kinase M1/2 decreases expression ISO Warfarin results in decreased expression of PKM mRNA CTD PMID:20493250 NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599 		JBrowse link
G Plp1 proteolipid protein 1 increases expression ISO Warfarin results in increased expression of PLP1 mRNA CTD PMID:27397090 NCBI chr  X:100,184,039...100,201,035
Ensembl chr  X:100,185,767...100,201,032 		JBrowse link
G Por cytochrome p450 oxidoreductase affects response to substance ISO POR gene SNP affects the susceptibility to Warfarin CTD PMID:27488389 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245 		JBrowse link
G Ppp1ca protein phosphatase 1 catalytic subunit alpha decreases expression ISO Warfarin results in decreased expression of PPP1CA mRNA CTD PMID:20493250 NCBI chr 1:201,485,117...201,488,734
Ensembl chr 1:201,485,085...201,497,327 		JBrowse link
G Ppp2r1a protein phosphatase 2 scaffold subunit A alpha increases expression ISO Warfarin results in increased expression of PPP2R1A mRNA CTD PMID:20493250 NCBI chr 1:60,540,223...60,559,467
Ensembl chr 1:60,540,194...60,560,129 		JBrowse link
G Proc protein C, inactivator of coagulation factors Va and VIIIa increases response to substance
affects response to substance		 ISO PROC protein results in increased susceptibility to Warfarin
PROC gene polymorphism affects the susceptibility to Warfarin		 CTD PMID:17048007 PMID:17496169 NCBI chr18:23,764,367...23,774,816
Ensembl chr18:23,764,368...23,775,133 		JBrowse link
G Pros1 protein S affects response to substance ISO PROS1 gene polymorphism affects the susceptibility to Warfarin; PROS1 protein affects the susceptibility to Warfarin CTD PMID:19752777 NCBI chr11:230,597...311,288
Ensembl chr11:230,696...311,286 		JBrowse link
G Prss53 serine protease 53 affects response to substance ISO PRSS53 gene SNP affects the susceptibility to Warfarin CTD PMID:21590310 NCBI chr 1:182,494,944...182,501,607
Ensembl chr 1:182,494,955...182,500,115 		JBrowse link
G Psma3 proteasome 20S subunit alpha 3 decreases expression ISO Warfarin results in decreased expression of PSMA3 mRNA CTD PMID:20493250 NCBI chr 6:89,483,741...89,503,775
Ensembl chr 6:89,483,727...89,504,965 		JBrowse link
G Psma6 proteasome 20S subunit alpha 6 decreases expression ISO Warfarin results in decreased expression of PSMA6 mRNA CTD PMID:20493250 NCBI chr 6:72,765,534...72,796,554
Ensembl chr 6:72,765,473...72,796,554 		JBrowse link
G Psmc2 proteasome 26S subunit, ATPase 2 decreases expression ISO Warfarin results in decreased expression of PSMC2 mRNA CTD PMID:20493250 NCBI chr 4:13,255,850...13,270,160
Ensembl chr 4:13,255,856...13,270,185 		JBrowse link
G Pth parathyroid hormone decreases activity ISO Warfarin results in decreased activity of PTH protein CTD PMID:11564701 NCBI chr 1:167,508,121...167,511,530
Ensembl chr 1:167,508,598...167,511,530 		JBrowse link
G Rab1a RAB1A, member RAS oncogene family decreases expression ISO Warfarin results in decreased expression of RAB1A mRNA CTD PMID:20493250 NCBI chr14:94,422,219...94,448,799
Ensembl chr14:94,415,275...94,448,248 		JBrowse link
G Rhoa ras homolog family member A decreases expression ISO Warfarin results in decreased expression of RHOA mRNA CTD PMID:20493250 NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746 		JBrowse link
G Rpl27 ribosomal protein L27 increases expression ISO Warfarin results in increased expression of RPL27 mRNA CTD PMID:20493250 NCBI chr10:86,375,511...86,379,210
Ensembl chr10:86,375,454...86,379,193 		JBrowse link
G Rpl9 ribosomal protein L9 increases expression ISO Warfarin results in increased expression of RPL9 mRNA CTD PMID:20493250 NCBI chr14:42,893,945...42,897,140
Ensembl chr14:42,893,942...42,897,136
Ensembl chr 3:42,893,942...42,897,136 		JBrowse link
G Rplp0 ribosomal protein lateral stalk subunit P0 increases expression ISO Warfarin results in increased expression of RPLP0 mRNA CTD PMID:20493250 NCBI chr12:41,054,363...41,057,632
Ensembl chr12:41,054,179...41,057,632 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions ISO epigallocatechin gallate promotes the reaction [Warfarin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of RPS6KB1 protein]]; Warfarin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of RPS6KB1 protein] CTD PMID:36162953 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908 		JBrowse link
G Rpsa ribosomal protein SA increases expression ISO Warfarin results in increased expression of RPSA mRNA CTD PMID:20493250 NCBI chr 8:119,851,225...119,855,103
Ensembl chr 8:119,851,225...119,855,247 		JBrowse link
G Runx1 RUNX family transcription factor 1 increases expression
multiple interactions		 EXP Warfarin results in increased expression of RUNX1 mRNA
Quercetin inhibits the reaction [Warfarin results in increased expression of RUNX1 mRNA]		 CTD PMID:23223575 NCBI chr11:31,839,880...32,074,427
Ensembl chr11:31,843,764...32,074,542 		JBrowse link
G Runx2 RUNX family transcription factor 2 multiple interactions ISO
EXP		 Warfarin inhibits the reaction [BMP2 protein results in increased activity of RUNX2 protein]; Warfarin inhibits the reaction [RUNX2 protein results in increased expression of ALPL mRNA]; Warfarin inhibits the reaction [RUNX2 protein results in increased expression of BGLAP mRNA]
[Warfarin co-treated with Vitamin K 1] affects the expression of RUNX2 mRNA; [Warfarin co-treated with Vitamin K 1] affects the expression of RUNX2 protein; [Warfarin co-treated with Vitamin K] results in increased expression of RUNX2 mRNA; Losartan affects the reaction [[Warfarin co-treated with Vitamin K 1] affects the expression of RUNX2 mRNA]; Losartan affects the reaction [[Warfarin co-treated with Vitamin K 1] affects the expression of RUNX2 protein]; Quercetin inhibits the reaction [[Warfarin co-treated with Vitamin K] results in increased expression of RUNX2 mRNA]		 CTD PMID:21910061 PMID:23117658 PMID:27412937 NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167 		JBrowse link
G Ruvbl2 RuvB-like AAA ATPase 2 decreases expression ISO Warfarin results in decreased expression of RUVBL2 mRNA CTD PMID:20493250 NCBI chr 1:95,902,014...95,915,247
Ensembl chr 1:95,901,701...95,915,342 		JBrowse link
G Sae1 SUMO1 activating enzyme subunit 1 decreases expression ISO Warfarin results in decreased expression of SAE1 mRNA CTD PMID:20493250 NCBI chr 1:77,030,961...77,086,937
Ensembl chr 1:77,030,965...77,086,986 		JBrowse link
G Sephs1 selenophosphate synthetase 1 increases expression ISO Warfarin results in increased expression of SEPHS1 mRNA CTD PMID:20493250 NCBI chr17:73,354,435...73,382,803
Ensembl chr17:73,356,530...73,382,593 		JBrowse link
G Serpinc1 serpin family C member 1 increases expression ISO Warfarin results in increased expression of SERPINC1 protein CTD PMID:73932 NCBI chr13:73,257,208...73,271,476
Ensembl chr13:73,257,179...73,284,293 		JBrowse link
G Slc15a2 solute carrier family 15 member 2 affects response to substance ISO SLC15A2 gene SNP affects the susceptibility to Warfarin CTD PMID:29234073 NCBI chr11:64,014,182...64,043,228
Ensembl chr11:64,014,182...64,043,225 		JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 affects response to substance ISO SLCO1B3 gene SNP affects the susceptibility to Warfarin CTD PMID:29234073 NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981 		JBrowse link
G Sost sclerostin affects response to substance ISO SOST affects the susceptibility to Warfarin CTD PMID:35038187 NCBI chr10:86,912,517...86,915,561
Ensembl chr10:86,911,517...86,915,561 		JBrowse link
G Sox5 SRY-box transcription factor 5 affects localization
decreases expression		 ISO Warfarin affects the localization of SOX5 protein
Warfarin results in decreased expression of SOX5 mRNA; Warfarin results in decreased expression of SOX5 protein		 CTD PMID:34520801 NCBI chr 4:176,781,375...177,736,833
Ensembl chr 4:176,785,892...177,736,852 		JBrowse link
G Sox9 SRY-box transcription factor 9 affects localization
multiple interactions		 ISO Warfarin affects the localization of SOX9 protein
leptomycin B inhibits the reaction [Warfarin affects the localization of SOX9 protein]		 CTD PMID:34520801 NCBI chr10:97,806,485...97,811,994
Ensembl chr10:97,806,485...97,811,994 		JBrowse link
G Sp7 Sp7 transcription factor multiple interactions ISO Warfarin inhibits the reaction [BMP2 protein results in increased expression of SP7 mRNA] CTD PMID:21910061 NCBI chr 7:133,484,609...133,494,788
Ensembl chr 7:133,484,609...133,494,847 		JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions ISO
EXP		 [Warfarin co-treated with Vitamin K 1] results in increased expression of SPP1 mRNA
[Quercetin co-treated with Warfarin] results in increased expression of SPP1 mRNA; [Warfarin co-treated with Vitamin K] results in increased expression of SPP1 mRNA		 CTD PMID:23117658 PMID:23223575 PMID:23990204 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162 		JBrowse link
G Stip1 stress-induced phosphoprotein 1 decreases expression ISO Warfarin results in decreased expression of STIP1 mRNA CTD PMID:20493250 NCBI chr 1:204,209,433...204,228,452
Ensembl chr 1:204,178,932...204,228,476 		JBrowse link
G Tagln transgelin multiple interactions ISO
EXP		 [Warfarin co-treated with Vitamin K 1] results in decreased expression of TAGLN mRNA
[Warfarin co-treated with Vitamin K co-treated with Quercetin] results in increased expression of TAGLN mRNA		 CTD PMID:23117658 PMID:23990204 NCBI chr 8:46,224,939...46,230,413
Ensembl chr 8:46,222,472...46,230,668 		JBrowse link
G Tcf4 transcription factor 4 increases expression
multiple interactions		 EXP Warfarin results in increased expression of TCF4 mRNA
[Warfarin co-treated with Vitamin K] results in increased expression of TCF4 mRNA; Quercetin inhibits the reaction [[Warfarin co-treated with Vitamin K] results in increased expression of TCF4 mRNA]; Quercetin inhibits the reaction [Warfarin results in increased expression of TCF4 mRNA]		 CTD PMID:23117658 NCBI chr18:62,941,739...63,288,126
Ensembl chr18:62,943,782...63,284,425 		JBrowse link
G Tcp1 t-complex 1 increases expression ISO Warfarin results in increased expression of TCP1 mRNA CTD PMID:20493250 NCBI chr 1:47,829,061...47,836,809
Ensembl chr 1:47,828,652...47,836,839 		JBrowse link
G Tgm2 transglutaminase 2 affects response to substance
multiple interactions
increases response to substance		 ISO
EXP		 [TGM2 protein affects the susceptibility to Warfarin] which affects the susceptibility to Quercetin; TGM2 protein affects the susceptibility to Warfarin
[Warfarin co-treated with Vitamin K] results in increased expression of and results in increased activity of TGM2 protein; Quercetin inhibits the reaction [[Warfarin co-treated with Vitamin K] results in increased expression of and results in increased activity of TGM2 protein]; Quercetin inhibits the reaction [Warfarin results in increased activity of TGM2 protein]; Warfarin results in increased expression of and results in increased activity of TGM2 protein
TGM2 protein results in increased susceptibility to Warfarin		 CTD PMID:23117658 NCBI chr 3:146,772,684...146,801,924
Ensembl chr 3:146,772,687...146,801,981 		JBrowse link
G Thop1 thimet oligopeptidase 1 increases expression ISO Warfarin results in increased expression of THOP1 mRNA CTD PMID:20493250 NCBI chr 7:8,632,911...8,645,339
Ensembl chr 7:8,632,916...8,645,275 		JBrowse link
G Tnf tumor necrosis factor decreases expression
increases expression
multiple interactions
decreases secretion		 EXP Warfarin results in decreased expression of TNF mRNA
Warfarin results in increased expression of TNF
[Warfarin co-treated with Vitamin K] results in increased expression of TNF mRNA
Warfarin results in decreased secretion of TNF protein		 CTD PMID:21565690 PMID:22342526 PMID:23117658 PMID:26742017 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 increases degradation
increases expression		 ISO Warfarin results in increased degradation of TP53 protein
Warfarin results in increased expression of TRP53 mRNA; Warfarin results in increased expression of TRP53 protein		 CTD PMID:14634213 PMID:29358327 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tuba1a tubulin, alpha 1A increases expression ISO Warfarin results in increased expression of TUBA1A mRNA CTD PMID:20493250 NCBI chr 7:130,113,214...130,116,880
Ensembl chr 7:130,081,032...130,196,186 		JBrowse link
G Tuba1b tubulin, alpha 1B decreases expression
increases expression		 ISO Warfarin results in decreased expression of TUBA1B mRNA
Warfarin results in increased expression of TUBA1B mRNA		 CTD PMID:20493250 NCBI chr 7:130,090,663...130,093,644
Ensembl chr 7:130,081,032...130,196,186 		JBrowse link
G Tubb5 tubulin, beta 5 class I decreases expression ISO Warfarin results in decreased expression of TUBB5 mRNA CTD PMID:20493250 NCBI chr20:2,912,779...2,916,928
Ensembl chr20:2,912,778...2,916,940 		JBrowse link
G Tufm Tu translation elongation factor, mitochondrial decreases expression ISO Warfarin results in decreased expression of TUFM mRNA CTD PMID:20493250 NCBI chr 1:181,073,788...181,077,395
Ensembl chr 1:181,073,788...181,077,395 		JBrowse link
G Tyro3 TYRO3 protein tyrosine kinase decreases expression ISO Warfarin results in decreased expression of TYRO3 mRNA CTD PMID:18772604 PMID:27397090 NCBI chr 3:106,777,686...106,797,154
Ensembl chr 3:106,777,635...106,797,142 		JBrowse link
G U2af2 U2 small nuclear RNA auxiliary factor 2 increases expression ISO Warfarin results in increased expression of U2AF2 mRNA CTD PMID:20493250 NCBI chr 1:68,760,911...68,779,730
Ensembl chr 1:68,760,924...68,778,492 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 multiple interactions
affects response to substance
increases metabolic processing		 ISO [UGT1A1 protein results in increased metabolism of Warfarin] which results in increased chemical synthesis of Glucuronides; [Warfarin binds to and results in decreased activity of UGT1A1 protein] which results in decreased glucuronidation of Estradiol; Warfarin binds to and results in decreased activity of UGT1A1 protein; Warfarin inhibits the reaction [UGT1A1 protein results in increased glucuronidation of Estradiol]
UGT1A1 gene SNP affects the susceptibility to Warfarin; UGT1A1 polymorphism affects the susceptibility to Warfarin		 CTD PMID:19408964 PMID:25312789 PMID:25393417 PMID:26223945 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 multiple interactions ISO [Warfarin binds to and results in increased activity of UGT1A3 protein] which results in increased glucuronidation of vorinostat; Warfarin binds to and results in increased activity of UGT1A3 protein; Warfarin promotes the reaction [UGT1A3 protein results in increased glucuronidation of vorinostat] CTD PMID:25393417 NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 multiple interactions ISO [Warfarin binds to and affects the activity of UGT1A9 protein] which affects the glucuronidation of Propofol; Warfarin affects the reaction [UGT1A9 protein results in increased glucuronidation of Propofol]; Warfarin binds to and affects the activity of UGT1A9 protein CTD PMID:25393417 NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt2b1 UDP glucuronosyltransferase 2 family, polypeptide B1 multiple interactions ISO [Warfarin binds to and results in decreased activity of UGT2B17 protein] which results in decreased glucuronidation of vorinostat; Warfarin binds to and results in decreased activity of UGT2B17 protein; Warfarin inhibits the reaction [UGT2B17 protein results in increased glucuronidation of vorinostat] CTD PMID:25393417 NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986 		JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 multiple interactions ISO [Warfarin binds to and results in decreased activity of UGT2B7 protein] which results in decreased glucuronidation of Zidovudine; Warfarin binds to and results in decreased activity of UGT2B7 protein; Warfarin inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Zidovudine] CTD PMID:25393417 NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604 		JBrowse link
G Usp5 ubiquitin specific peptidase 5 decreases expression ISO Warfarin results in decreased expression of USP5 mRNA CTD PMID:20493250 NCBI chr 4:157,619,663...157,634,681
Ensembl chr 4:157,619,643...157,634,711 		JBrowse link
G Vcp valosin-containing protein decreases expression
increases expression		 ISO Warfarin results in decreased expression of VCP mRNA
Warfarin results in increased expression of VCP mRNA		 CTD PMID:20493250 NCBI chr 5:57,210,167...57,229,571
Ensembl chr 5:57,210,168...57,229,571 		JBrowse link
G Vdr vitamin D receptor affects response to substance ISO VDR gene SNP affects the susceptibility to Warfarin CTD PMID:28262345 PMID:29298995 NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677 		JBrowse link
G Vegfa vascular endothelial growth factor A affects response to substance
multiple interactions		 ISO VEGFA gene SNP affects the susceptibility to Warfarin
epigallocatechin gallate promotes the reaction [Warfarin inhibits the reaction [Hydrogen Peroxide results in increased expression of VEGFA mRNA]]; epigallocatechin gallate promotes the reaction [Warfarin inhibits the reaction [Hydrogen Peroxide results in increased expression of VEGFA protein]]; Warfarin inhibits the reaction [Hydrogen Peroxide results in increased expression of VEGFA mRNA]; Warfarin inhibits the reaction [Hydrogen Peroxide results in increased expression of VEGFA protein]		 CTD PMID:31068094 PMID:36162953 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Vim vimentin decreases expression ISO Warfarin results in decreased expression of VIM protein CTD PMID:26206560 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187 		JBrowse link
G Vkorc1 vitamin K epoxide reductase complex, subunit 1 multiple interactions
decreases activity
affects abundance
decreases response to substance
affects response to substance
affects metabolic processing
increases response to substance
decreases metabolic processing		 ISO
EXP		 [CYP4F2 gene polymorphism co-treated with VKORC1 gene mutant form] affects the susceptibility to Warfarin; Warfarin binds to and results in decreased activity of VKORC1 protein; Warfarin inhibits the reaction [VKORC1 protein results in increased reduction of Vitamin K 1]; Warfarin inhibits the reaction [VKORC1 protein results in increased reduction of vitamin K1 oxide]
Warfarin results in decreased activity of VKORC1 protein
VKORC1 gene polymorphism affects the abundance of Warfarin
VKORC1 3' UTR results in decreased susceptibility to Warfarin; VKORC1 gene mutant form results in decreased susceptibility to Warfarin; VKORC1 gene polymorphism results in decreased susceptibility to Warfarin
VKORC1 3' UTR SNP affects the susceptibility to Warfarin; VKORC1 affects the susceptibility to Warfarin; VKORC1 alternative form affects the susceptibility to Warfarin; VKORC1 gene affects the susceptibility to Warfarin; VKORC1 gene mutant form affects the susceptibility to Warfarin; VKORC1 gene polymorphism affects the susceptibility to Warfarin; VKORC1 gene SNP affects the susceptibility to Warfarin; VKORC1 intron polymorphism affects the susceptibility to Warfarin; VKORC1 intron SNP affects the susceptibility to Warfarin; VKORC1 polymorphism affects the susceptibility to Warfarin; VKORC1 promoter polymorphism affects the susceptibility to Warfarin; VKORC1 promoter SNP affects the susceptibility to Warfarin; VKORC1 protein affects the susceptibility to Warfarin; VKORC1 protein polymorphism affects the susceptibility to Warfarin; VKORC1 protein SNP affects the susceptibility to Warfarin; VKORC1 SNP affects the susceptibility to Warfarin
Warfarin inhibits the reaction [VKORC1 protein affects the reduction of vitamin K1 oxide]
VKORC1 gene mutant form results in decreased susceptibility to Warfarin; VKORC1 protein polymorphism results in decreased susceptibility to Warfarin
VKORC1 protein mutant form affects the susceptibility to Warfarin
VKORC1 protein affects the metabolism of Warfarin
VKORC1 intron polymorphism results in increased susceptibility to Warfarin; VKORC1 protein results in increased susceptibility to Warfarin; VKORC1 results in increased susceptibility to Warfarin
VKORC1 gene polymorphism results in decreased metabolism of Warfarin		 CTD PMID:14765194 PMID:14765195 PMID:15358623 PMID:15578879 PMID:15630486 More... NCBI chr 1:182,502,491...182,505,012
Ensembl chr 1:182,500,844...182,505,008 		JBrowse link
G Vkorc1l1 vitamin K epoxide reductase complex, subunit 1-like 1 multiple interactions ISO
EXP		 Warfarin affects the reaction [VKORC1L1 protein results in increased reduction of vitamin K1 oxide]; Warfarin binds to and results in decreased activity of VKORC1L1 protein; Warfarin inhibits the reaction [VKORC1L1 protein results in increased metabolism of vitamin K1 oxide]; Warfarin inhibits the reaction [VKORC1L1 protein results in increased reduction of Vitamin K 1]; Warfarin inhibits the reaction [VKORC1L1 protein results in increased reduction of vitamin K1 oxide] CTD PMID:23710884 PMID:23928358 PMID:29581108 NCBI chr12:26,717,959...26,768,193
Ensembl chr12:26,623,976...26,768,225 		JBrowse link
G Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon increases expression ISO Warfarin results in increased expression of YWHAE mRNA CTD PMID:20493250 NCBI chr10:60,584,665...60,622,352
Ensembl chr10:60,584,652...60,671,589 		JBrowse link
G Zeb1 zinc finger E-box binding homeobox 1 decreases expression ISO Warfarin results in decreased expression of ZEB1 protein CTD PMID:26206560 NCBI chr17:51,948,948...52,116,018
Ensembl chr17:51,948,948...52,115,214 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19932
    chemical entity 19930
      molecular entity 19930
        polyatomic entity 19887
          molecule 19779
            cyclic compound 19572
              aromatic compound 19414
                organic aromatic compound 19414
                  phenylpropanoid 11310
                    coumarins 4147
                      hydroxycoumarin 357
                        (S)-Neomammein 0
                        11-Methylgerberinol 0
                        2-(5,7-dihydroxy-4-methyl-2-oxo-1-benzopyran-3-yl)acetic acid ethyl ester 0
                        2-hydroxy-Alternariol 0
                        3,4,7-trihydroxy-6-methylcoumarin 0
                        3,7-dihydroxy-2H-chromen-2-one 0
                        3,8-dibromo-7-hydroxy-4-methyl-1-benzopyran-2-one 0
                        3-(1,1-Dimethylallyl)-8-hydroxy-7-methoxycoumarin 0
                        3-(1,1-Dimethylallyl)scopoletin 0
                        3-(4-azidobenzyl)-4-hydroxycoumarin 0
                        3-(dimethylamino)benzoic acid (7-hydroxy-2-oxo-1-benzopyran-4-yl)methyl ester 0
                        3-Amino-4,7-dihydroxy-8-chlorocoumarin 0
                        3-Hydroxyalternariol 5-O-methyl ether 0
                        3-O-demethylaltenuisol 0
                        3-[3-[(2,4-dinitrophenyl)hydrazinylidene]-1-phenylbutyl]-4-hydroxy-1-benzopyran-2-one 0
                        3-amino-4,7-dihydroxy-8-methylcoumarin 0
                        3-amino-4,7-dihydroxycoumarin + 0
                        3-bromo-7-hydroxy-4,8-dimethyl-1-benzopyran-2-one 0
                        3-hydroxy-1-benzopyran-2-one 0
                        3-hydroxy-2-oxo-2H-chromene-4,6-dicarboxylic acid 0
                        3-hydroxy-6-[(E)-2-methoxyethenyl]-7-methyl-2H-chromen-2-one 0
                        3-hydroxy-6-methyl-2H-chromen-2-one 0
                        4'-Hydroxy-R-phenprocoumon 0
                        4,6,7-trihydroxy-2H-chromen-2-one 0
                        4,6-dihydroxy-3,7-dimethylcoumarin 0
                        4,6-dihydroxy-7-formyl-3-methylcoumarin 0
                        4,6-dihydroxy-7-hydroxymethyl-3-methoxymethylcoumarin 0
                        4,6-dihydroxy-7-hydroxymethyl-3-methylcoumarin 0
                        4,7-Dihydroxy-2H-1-benzopyran-2-one 0
                        4,7-dihydroxy-5-methylcoumarin + 0
                        4-Hydroxyalternariol 0
                        4-ethyl-7-hydroxy-3-(p-methoxyphenyl)coumarin 0
                        4-hydroxy-3-(1-piperidinylmethyl)-1-benzopyran-2-one 0
                        4-hydroxy-3-(2-hydroxy-3-oxo-1-phenylbutyl)-2H-chromen-2-one 3
                        4-hydroxy-3-(3-hydroxy-1-phenylbutyl)-2H-chromen-2-one 0
                        4-hydroxy-3-(3-oxo-1-phenylbutyl)-1-benzopyran-2-one + 194
                        4-hydroxy-3-[1-(2-hydroxyphenyl)-3-oxobutyl]-2H-chromen-2-one 0
                        4-hydroxy-3-[1-(4-hydroxyphenyl)-3-oxobutyl]-2H-chromen-2-one 3
                        4-hydroxycoumarin 8
                        4-methylumbelliferone + 32
                        5,7-Dihydroxy-4-methylcoumarin 0
                        5,7-dihydroxy-4-methyl-3-(phenylmethyl)-1-benzopyran-2-one 0
                        5,7-dihydroxy-6-(3-methylbut-2-enyl)-8-(3-methylbutanoyl)-4-pentyl-2H-chromen-2-one 0
                        5,7-dihydroxy-8-(3-methylbut-2-enyl)-6-(3-methylbutanoyl)-4-propyl-2H-chromen-2-one 0
                        5-De-O-methyltoddanol 0
                        5-[[(4,7-Dihydroxy-2-oxo-2H-1-benzopyran-3-yl)amino]carbonyl]-4-methyl-1H-pyrrole-3-carboxylate 0
                        5-hydroxy-2H-chromen-2-one 0
                        6,7-dihydroxy-4-methylcoumarin 0
                        6,8-difluoro-7-hydroxy-4-methylcoumarin + 0
                        6-Formylumbelliferone 0
                        6-Hydroxy-7-methylesculetin 0
                        6-Hydroxy-R-acenocoumarol 0
                        6-Hydroxy-R-phenprocoumon 0
                        6-chloro-3-[2-[4-[2,3-dihydro-1,4-benzodioxin-3-yl(oxo)methyl]-1-piperazinyl]-2-oxoethyl]-7-hydroxy-4-methyl-1-benzopyran-2-one 0
                        6-chloro-4-[[(2-fluorophenyl)methyl-methylamino]methyl]-7-hydroxy-1-benzopyran-2-one 0
                        6-chloro-4-hydroxycoumarin 0
                        6-chloro-7-hydroxy-4-(4-morpholinylmethyl)-1-benzopyran-2-one 0
                        6-ethyl-7-hydroxy-4-[[4-(2-hydroxyethyl)-1-piperazinyl]methyl]-1-benzopyran-2-one 0
                        6-hydroxy-4-methyl-2-oxo-2H-chromen-7-yl acetate 0
                        7,7'-Dihydroxy-6,8'-bicoumarin 0
                        7,8-dihydroxy-4-methyl-1-benzopyran-2-one + 17
                        7,8-dihydroxycoumarin + 24
                        7-(diethylamino)-4-hydroxy-1-benzopyran-2-one 0
                        7-(gamma,gamma-dimethylallyloxy)-6-hydroxy-4-methylcoumarin 0
                        7-Hydroxy-4-(methoxymethyl)coumarin 0
                        7-Hydroxy-6-methyl-2H-1-benzopyran-2-one 0
                        7-Hydroxy-R-acenocoumarol 0
                        7-Hydroxy-R-phenprocoumon 0
                        7-Hydroxywarfarin 2
                        7-demethylsiderin 0
                        7-demethylsuberosin + 0
                        7-hydroxy-3-(2-methylbut-3-en-2-yl)-2H-chromen-2-one 0
                        7-hydroxy-3-(4-methoxyphenyl)-4-methylcoumarin 0
                        7-hydroxy-3-(4-methoxyphenyl)-4-propyl-2H-1-benzopyran-2-one 0
                        7-hydroxy-3-methoxy-2-oxo-2h-chromene-6-carboxylic acid 0
                        7-hydroxy-6-(3-oxobutyl)-2H-chromen-2-one 0
                        7-hydroxy-6-(hydroxymethyl)-2H-chromen-2-one 0
                        7-hydroxy-8-[[4-(2-hydroxyethyl)-1-piperazinyl]methyl]-4-methyl-1-benzopyran-2-one 0
                        7-hydroxy-8-methoxycoumarin 0
                        7-hydroxy-8-methyl-4-[[methyl-(phenylmethyl)amino]methyl]-1-benzopyran-2-one 0
                        8-Hydroxy-7-methoxy-2H-1-benzopyran-2-one 0
                        8-Hydroxy-R-acenocoumarol 0
                        8-Hydroxy-R-phenprocoumon 0
                        8-Methoxygravelliferone 0
                        8-[(3,3-dimethyloxiran-2-yl)methyl]-6-hydroxy-7-methoxy-2H-chromen-2-one 0
                        8-[(3,3-dimethyloxiran-2-yl)methyl]-7-hydroxy-2H-chromen-2-one 0
                        8-desmethylnovobiocic acid 0
                        8-geranylesculetin 0
                        8-geranylumbelliferone 0
                        Altertenuol 0
                        Apigravin 0
                        Aspyranochromenone A 0
                        Aspyranochromenone B 0
                        Bicoumanigrin 0
                        Celerin 0
                        Chlorobiocic acid 0
                        Coumabiocin F 0
                        Coumachlor 2
                        Coumafuryl 0
                        Coumaphos anti-dimer 0
                        Coumaphos syn-dimer 0
                        Coumatetralyl 2
                        Coumermic acid 0
                        Coumeroic acid 0
                        Cralactone A 0
                        Cralactone B 0
                        Cristaldehyde A 0
                        Dehydrowarfarin 0
                        Epicoccalone 0
                        Fraxidin 0
                        Fraxinol 0
                        Gerberinol 0
                        Gravelliferone 0