CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: GW 4064
Accession: CHEBI:79997
browse the term
Definition: A stilbenoid that has formula C28H22Cl3NO4.
Synonyms: exact_synonym: GW4064
related_synonym: Formula=C28H22Cl3NO4; InChI=1S/C28H22Cl3NO4/c1-16(2)27-21(26(32-36-27)25-22(29)7-4-8-23(25)30)15-35-20-12-11-18(24(31)14-20)10-9-17-5-3-6-19(13-17)28(33)34/h3-14,16H,15H2,1-2H3,(H,33,34)/b10-9+; InChIKey=BYTNEISLBIENSA-MDZDMXLPSA-N; SMILES=CC(C)c1onc(c1COc1ccc(\\C=C\\c2cccc(c2)C(O)=O)c(Cl)c1)-c1c(Cl)cccc1Cl
xref: CAS:278779-30-9; KEGG:C15635
xref_mesh: MESH:C412815
xref: PDBeChem:064
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A1cf
APOBEC1 complementation factor
increases expression
EXP
GW 4064 results in increased expression of A1CF mRNA
CTD
PMID:26655953
NCBI chr19:31,846,156...31,929,765
Ensembl chr19:31,846,164...31,926,395
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Abca1
ATP-binding cassette, sub-family A member 1
decreases expression
ISO
GW 4064 results in decreased expression of ABCA1 mRNA
CTD
PMID:31437187
NCBI chr 4:53,030,789...53,159,988
Ensembl chr 4:53,030,787...53,159,895
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Abcb11
ATP-binding cassette, sub-family B member 11
increases expression multiple interactions
ISO EXP
GW 4064 results in increased expression of ABCB11 mRNA [pregna-4,17-diene-3,16-dione co-treated with GW 4064] results in increased expression of ABCB11 mRNA; alpha-Linolenic Acid promotes the reaction [GW 4064 results in increased expression of ABCB11 mRNA]; Arachidonic Acid promotes the reaction [GW 4064 results in increased expression of ABCB11 mRNA]; Clavulanic Acid inhibits the reaction [GW 4064 results in increased expression of ABCB11 mRNA]; Docosahexaenoic Acids promotes the reaction [GW 4064 results in increased expression of ABCB11 mRNA]; epigallocatechin gallate inhibits the reaction [GW 4064 results in increased expression of ABCB11 mRNA]; LG 100268 inhibits the reaction [GW 4064 results in increased expression of ABCB11 mRNA]; pregna-4,17-diene-3,16-dione inhibits the reaction [GW 4064 results in increased expression of ABCB11 mRNA] [GW 4064 binds to and results in increased activity of NR1H4 protein] which results in increased expression of ABCB11 mRNA; ATP7B protein affects the reaction [GW 4064 results in increased expression of ABCB11 mRNA]; epiallopregnanolone sulfate inhibits the reaction [GW 4064 results in increased expression of ABCB11 mRNA]; epiallopregnanolone sulfate inhibits the reaction [GW 4064 results in increased expression of ABCB11 protein]; GW 4064 inhibits the reaction [ATP7B gene mutant form results in decreased expression of ABCB11 mRNA]; GW 4064 inhibits the reaction [Oleanolic Acid results in decreased expression of ABCB11 mRNA]; GW 4064 inhibits the reaction [Oleanolic Acid results in decreased expression of ABCB11 protein]; NR1H4 gene mutant form inhibits the reaction [GW 4064 results in increased expression of ABCB11 mRNA]; NR1H4 protein promotes the reaction [GW 4064 results in increased expression of ABCB11 protein] GW 4064 results in increased expression of ABCB11 mRNA; GW 4064 results in increased expression of ABCB11 protein GW 4064 inhibits the reaction [Ethinyl Estradiol results in decreased expression of ABCB11 mRNA] GW 4064 increases expression of Abcb11 mRNA in primary hepatocytes GW 4064 inhibits the reaction [17alpha-ethynylestradiol decreases expression of Abcb11 mRNA in primary hepatocytes]
CTD RGD
PMID:12519787 PMID:12525500 PMID:14623915 PMID:15307955 PMID:15644430 PMID:15911693 PMID:22178739 PMID:22540009 PMID:22918042 PMID:22961653 PMID:26241054 PMID:27090119 PMID:27609522 PMID:34767876 PMID:37028458 PMID:27090119 PMID:27090119 More...
RGD:15090804 , RGD:15090804
NCBI chr 2:69,068,626...69,172,960
Ensembl chr 2:69,068,626...69,172,958
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Abcb4
ATP-binding cassette, sub-family B member 4
increases expression multiple interactions
ISO EXP
GW 4064 results in increased expression of ABCB4 mRNA [[GW 4064 binds to and results in increased activity of NR1H4 protein] which binds to ABCB4 promoter] which results in increased expression of ABCB4 mRNA
CTD
PMID:14527955 PMID:14623915 PMID:15644430 PMID:27609522
NCBI chr 5:8,943,614...9,009,226
Ensembl chr 5:8,943,717...9,009,231
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Abcc2
ATP-binding cassette, sub-family member 2
multiple interactions increases expression
ISO EXP
GW 4064 inhibits the reaction [Ethinyl Estradiol results in decreased expression of ABCC2 protein] GW 4064 results in increased expression of ABCC2 mRNA GW 4064 increases expression of Abcc2 mRNA in primary hepatocytes GW 4064 inhibits the reaction [17alpha-ethynylestradiol decreases expression of Abcc2 mRNA in primary hepatocytes] GW 4064 inhibits the reaction [Oleanolic Acid results in decreased expression of ABCC2 mRNA]; GW 4064 inhibits the reaction [Oleanolic Acid results in decreased expression of ABCC2 protein]
CTD RGD
PMID:14623915 PMID:15644430 PMID:27090119 PMID:37028458 PMID:27090119 PMID:27090119 More...
RGD:15090804 , RGD:15090804
NCBI chr19:43,770,747...43,826,771
Ensembl chr19:43,770,631...43,829,179
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Abcc3
ATP-binding cassette, sub-family C member 3
increases expression
EXP
GW 4064 results in increased expression of ABCC3 mRNA
CTD
PMID:27609522
NCBI chr11:94,234,121...94,283,843
Ensembl chr11:94,234,121...94,283,823
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Abcc6
ATP-binding cassette, sub-family C member 6
increases expression
EXP
GW 4064 results in increased expression of ABCC6 mRNA
CTD
PMID:26655953
NCBI chr 7:45,625,804...45,679,915
Ensembl chr 7:45,616,979...45,679,726
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Abcg2
ATP binding cassette subfamily G member 2 (Junior blood group)
multiple interactions decreases expression
ISO
GW 4064 inhibits the reaction [Ethanol results in increased expression of ABCG2 mRNA] GW 4064 results in decreased expression of ABCG2 mRNA
CTD
PMID:34217791
NCBI chr 6:58,561,476...58,669,436
Ensembl chr 6:58,561,508...58,672,661
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Abcg5
ATP binding cassette subfamily G member 5
multiple interactions increases expression
EXP ISO
FGF15 gene mutant form inhibits the reaction [GW 4064 results in increased expression of ABCG5 mRNA]; NR1H4 gene mutant form inhibits the reaction [GW 4064 results in increased expression of ABCG5 mRNA] Clavulanic Acid inhibits the reaction [GW 4064 results in increased expression of ABCG5 mRNA]; GW 4064 inhibits the reaction [Clavulanic Acid results in decreased expression of ABCG5 mRNA]; GW 4064 inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased expression of ABCG5 mRNA]; pregna-4,17-diene-3,16-dione inhibits the reaction [GW 4064 results in increased expression of ABCG5 mRNA]
CTD
PMID:22918042 PMID:30996006 PMID:34767876
NCBI chr17:84,965,602...84,990,439
Ensembl chr17:84,965,662...84,990,439
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Abcg8
ATP binding cassette subfamily G member 8
multiple interactions increases expression
EXP
FGF15 gene mutant form inhibits the reaction [GW 4064 results in increased expression of ABCG8 mRNA]
CTD
PMID:30996006
NCBI chr17:84,983,730...85,007,761
Ensembl chr17:84,983,730...85,007,761
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Abhd15
abhydrolase domain containing 15
increases expression
EXP
GW 4064 results in increased expression of ABHD15 mRNA
CTD
PMID:26655953
NCBI chr11:77,405,943...77,411,454
Ensembl chr11:77,405,947...77,429,433
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Abi3bp
ABI family member 3 binding protein
decreases expression
EXP
GW 4064 results in decreased expression of ABI3BP mRNA
CTD
PMID:26655953
NCBI chr16:56,298,179...56,510,498
Ensembl chr16:56,298,241...56,510,498
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Acaa2
acetyl-CoA acyltransferase 2
multiple interactions
ISO
[GW 4064 co-treated with Oleic Acid] results in decreased expression of ACAA2 mRNA
CTD
PMID:30611723
NCBI chr18:74,912,283...74,939,278
Ensembl chr18:74,912,268...74,939,279
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Acaca
acetyl-Coenzyme A carboxylase alpha
multiple interactions
ISO
[GW 4064 co-treated with Oleic Acid] results in decreased expression of ACACA mRNA
CTD
PMID:30611723
NCBI chr11:84,020,461...84,292,477
Ensembl chr11:84,020,498...84,292,477
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Acacb
acetyl-Coenzyme A carboxylase beta
multiple interactions
ISO
[GW 4064 co-treated with Oleic Acid] results in decreased expression of ACACB mRNA
CTD
PMID:30611723
NCBI chr 5:114,284,748...114,388,822
Ensembl chr 5:114,284,596...114,388,822
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Acadl
acyl-Coenzyme A dehydrogenase, long-chain
decreases expression multiple interactions
ISO
GW 4064 results in decreased expression of ACADL mRNA [GW 4064 co-treated with Oleic Acid] results in decreased expression of ACADL mRNA
CTD
PMID:30611723
NCBI chr 1:66,869,998...66,902,468
Ensembl chr 1:66,869,998...66,902,436
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Acadm
acyl-Coenzyme A dehydrogenase, medium chain
decreases expression multiple interactions
ISO
GW 4064 results in decreased expression of ACADM mRNA [GW 4064 co-treated with Oleic Acid] results in decreased expression of ACADM mRNA
CTD
PMID:30611723
NCBI chr 3:153,627,990...153,650,280
Ensembl chr 3:153,627,994...153,650,269
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Acads
acyl-Coenzyme A dehydrogenase, short chain
multiple interactions increases expression
ISO
[GW 4064 co-treated with Oleic Acid] results in decreased expression of ACADS mRNA GW 4064 results in increased expression of ACADS mRNA
CTD
PMID:30611723
NCBI chr 5:115,248,358...115,257,405
Ensembl chr 5:115,248,358...115,257,405
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Acadvl
acyl-Coenzyme A dehydrogenase, very long chain
multiple interactions
ISO
[GW 4064 co-treated with Oleic Acid] results in decreased expression of ACADVL mRNA
CTD
PMID:30611723
NCBI chr11:69,901,009...69,906,254
Ensembl chr11:69,901,009...69,906,237
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Acat1
acetyl-Coenzyme A acetyltransferase 1
decreases expression multiple interactions
ISO
GW 4064 results in decreased expression of ACAT1 mRNA [GW 4064 co-treated with Oleic Acid] results in decreased expression of ACAT1 mRNA
CTD
PMID:30611723
NCBI chr 9:53,491,822...53,521,650
Ensembl chr 9:53,491,822...53,521,682
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Acat2
acetyl-Coenzyme A acetyltransferase 2
increases expression multiple interactions
EXP ISO
GW 4064 results in increased expression of ACAT2 mRNA [GW 4064 co-treated with Oleic Acid] results in decreased expression of ACAT2 mRNA
CTD
PMID:26655953 PMID:30611723
NCBI chr17:13,161,929...13,179,612
Ensembl chr17:13,161,777...13,179,634
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Acat3
acetyl-Coenzyme A acetyltransferase 3
increases expression
EXP
GW 4064 results in increased expression of ACAT3 mRNA
CTD
PMID:26655953
NCBI chr17:13,142,720...13,159,482
Ensembl chr17:13,142,700...13,159,487
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Ace
angiotensin I converting enzyme
increases expression
EXP
GW 4064 results in increased expression of ACE mRNA
CTD
PMID:26655953
NCBI chr11:105,858,774...105,880,790
Ensembl chr11:105,858,771...105,880,790
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Ace2
angiotensin converting enzyme 2
increases expression
EXP
GW 4064 results in increased expression of ACE2 mRNA
CTD
PMID:26655953
NCBI chr X:162,922,338...162,971,414
Ensembl chr X:162,922,328...162,971,416
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Acly
ATP citrate lyase
multiple interactions
ISO
[GW 4064 co-treated with Oleic Acid] results in decreased expression of ACLY mRNA
CTD
PMID:30611723
NCBI chr11:100,367,178...100,418,826
Ensembl chr11:100,367,179...100,418,826
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Acnat2
acyl-coenzyme A amino acid N-acyltransferase 2
decreases expression
EXP
GW 4064 results in decreased expression of ACNAT2 mRNA
CTD
PMID:26655953
NCBI chr 4:49,374,458...49,408,151
Ensembl chr 4:49,379,840...49,408,151
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Acot1
acyl-CoA thioesterase 1
multiple interactions
ISO
[GW 4064 co-treated with Oleic Acid] results in decreased expression of ACOT1 mRNA
CTD
PMID:30611723
NCBI chr12:84,056,276...84,064,444
Ensembl chr12:84,056,264...84,065,145
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Acot12
acyl-CoA thioesterase 12
increases expression decreases expression multiple interactions
EXP ISO
GW 4064 results in increased expression of ACOT12 mRNA GW 4064 results in decreased expression of ACOT12 mRNA [GW 4064 co-treated with Oleic Acid] results in decreased expression of ACOT12 mRNA
CTD
PMID:26655953 PMID:30611723
NCBI chr13:91,889,635...91,934,271
Ensembl chr13:91,889,631...91,934,267
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Acot3
acyl-CoA thioesterase 3
increases expression
EXP
GW 4064 results in increased expression of ACOT3 mRNA
CTD
PMID:26655953
NCBI chr12:84,098,918...84,107,174
Ensembl chr12:84,098,918...84,107,176
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Acot4
acyl-CoA thioesterase 4
increases expression multiple interactions
EXP ISO
GW 4064 results in increased expression of ACOT4 mRNA [GW 4064 co-treated with Oleic Acid] results in decreased expression of ACOT4 mRNA
CTD
PMID:26655953 PMID:30611723
NCBI chr12:84,084,028...84,091,497
Ensembl chr12:84,085,153...84,095,375
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Acot5
acyl-CoA thioesterase 5
increases expression
EXP
GW 4064 results in increased expression of ACOT5 mRNA
CTD
PMID:26655953
NCBI chr12:84,115,908...84,122,798
Ensembl chr12:84,116,099...84,122,794
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Acot6
acyl-CoA thioesterase 6
multiple interactions decreases expression
ISO
[GW 4064 co-treated with Oleic Acid] results in decreased expression of ACOT6 mRNA GW 4064 results in decreased expression of ACOT6 mRNA
CTD
PMID:30611723
NCBI chr12:84,147,538...84,158,128
Ensembl chr12:84,147,428...84,158,123
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Acot7
acyl-CoA thioesterase 7
multiple interactions increases expression
ISO
[GW 4064 co-treated with Oleic Acid] results in decreased expression of ACOT7 mRNA GW 4064 results in increased expression of ACOT7 mRNA
CTD
PMID:30611723
NCBI chr 4:152,258,872...152,356,312
Ensembl chr 4:152,262,591...152,356,312
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Acot8
acyl-CoA thioesterase 8
multiple interactions
ISO
[GW 4064 co-treated with Oleic Acid] results in decreased expression of ACOT8 mRNA
CTD
PMID:30611723
NCBI chr 2:164,634,688...164,662,132
Ensembl chr 2:164,634,685...164,646,802
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Acox1
acyl-Coenzyme A oxidase 1, palmitoyl
multiple interactions decreases expression
ISO
[GW 4064 co-treated with Oleic Acid] results in decreased expression of ACOX1 mRNA GW 4064 results in decreased expression of ACOX1 mRNA
CTD
PMID:30611723 PMID:31437187
NCBI chr11:116,062,714...116,089,605
Ensembl chr11:116,062,714...116,089,871
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Acox2
acyl-Coenzyme A oxidase 2, branched chain
multiple interactions decreases expression
ISO
[GW 4064 co-treated with Oleic Acid] results in decreased expression of ACOX2 mRNA GW 4064 results in decreased expression of ACOX2 mRNA
CTD
PMID:30611723
NCBI chr14:14,210,406...14,244,262
Ensembl chr14:14,210,420...14,244,262
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Acsl3
acyl-CoA synthetase long-chain family member 3
multiple interactions increases expression
ISO
[GW 4064 co-treated with Oleic Acid] results in decreased expression of ACSL3 mRNA GW 4064 results in increased expression of ACSL3 mRNA
CTD
PMID:30611723
NCBI chr 1:78,635,600...78,685,462
Ensembl chr 1:78,635,542...78,685,460
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Acsl4
acyl-CoA synthetase long-chain family member 4
multiple interactions
ISO
[GW 4064 co-treated with Oleic Acid] results in decreased expression of ACSL4 mRNA
CTD
PMID:30611723
NCBI chr X:141,100,989...141,173,792
Ensembl chr X:141,100,989...141,173,531
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Acsl5
acyl-CoA synthetase long-chain family member 5
increases expression
ISO
GW 4064 results in increased expression of ACSL5 mRNA
CTD
PMID:30611723
NCBI chr19:55,240,298...55,285,060
Ensembl chr19:55,240,370...55,286,152
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Acsm1
acyl-CoA synthetase medium-chain family member 1
increases expression
EXP
GW 4064 results in increased expression of ACSM1 mRNA
CTD
PMID:26655953
NCBI chr 7:119,217,035...119,261,738
Ensembl chr 7:119,206,249...119,261,738
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Actg1
actin, gamma, cytoplasmic 1
multiple interactions
EXP
GW 4064 promotes the reaction [NR1H4 protein binds to ACTG1 gene]
CTD
PMID:20091679
NCBI chr11:120,236,513...120,239,321
Ensembl chr11:120,236,516...120,239,368
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Adamts15
ADAM metallopeptidase with thrombospondin type 1 motif 15
increases expression
EXP
GW 4064 results in increased expression of ADAMTS15 mRNA
CTD
PMID:26655953
NCBI chr 9:30,810,451...30,833,853
Ensembl chr 9:30,810,451...30,833,748
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Adamts5
ADAM metallopeptidase with thrombospondin type 1 motif 5
decreases expression
EXP
GW 4064 results in decreased expression of ADAMTS5 mRNA
CTD
PMID:26655953
NCBI chr16:85,655,045...85,698,013
Ensembl chr16:85,653,061...85,698,716
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Adgra1
adhesion G protein-coupled receptor A1
decreases expression
EXP
GW 4064 results in decreased expression of ADGRA1 mRNA
CTD
PMID:26655953
NCBI chr 7:139,414,014...139,458,004
Ensembl chr 7:139,414,090...139,458,004
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Adgre1
adhesion G protein-coupled receptor E1
decreases expression
EXP
GW 4064 results in decreased expression of ADGRE1 mRNA
CTD
PMID:23371517
NCBI chr17:57,665,650...57,790,527
Ensembl chr17:57,665,691...57,790,527
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Adgrf4
adhesion G protein-coupled receptor F4
decreases expression
EXP
GW 4064 results in decreased expression of ADGRF4 mRNA
CTD
PMID:26655953
NCBI chr17:42,967,099...43,008,460
Ensembl chr17:42,967,782...43,003,175
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Adh7
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
increases expression
EXP
GW 4064 results in increased expression of ADH7 mRNA
CTD
PMID:26655953
NCBI chr 3:137,903,828...137,937,803
Ensembl chr 3:137,923,521...137,939,143
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Adhfe1
alcohol dehydrogenase, iron containing, 1
increases expression
EXP
GW 4064 results in increased expression of ADHFE1 mRNA
CTD
PMID:26655953
NCBI chr 1:9,618,173...9,648,195
Ensembl chr 1:9,618,173...9,650,898
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Adtrp
androgen dependent TFPI regulating protein
increases expression
EXP
GW 4064 results in increased expression of ADTRP mRNA
CTD
PMID:26655953
NCBI chr13:41,916,621...42,001,092
Ensembl chr13:41,916,624...42,001,160
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Agpat1
1-acylglycerol-3-phosphate O-acyltransferase 1
increases expression multiple interactions
ISO
GW 4064 results in increased expression of AGPAT1 mRNA [GW 4064 co-treated with Oleic Acid] results in decreased expression of AGPAT1 mRNA
CTD
PMID:30611723
NCBI chr17:34,823,164...34,832,392
Ensembl chr17:34,823,236...34,832,423
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Agpat2
1-acylglycerol-3-phosphate O-acyltransferase 2
increases expression
ISO
GW 4064 results in increased expression of AGPAT2 mRNA
CTD
PMID:30611723
NCBI chr 2:26,483,069...26,494,429
Ensembl chr 2:26,483,069...26,494,429
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Ahcyl2
S-adenosylhomocysteine hydrolase-like 2
decreases expression multiple interactions
EXP
GW 4064 results in decreased expression of AHCYL2 mRNA NR0B2 protein promotes the reaction [GW 4064 results in decreased expression of AHCYL2 mRNA]
CTD
PMID:29416063
NCBI chr 6:29,768,378...29,912,309
Ensembl chr 6:29,768,010...29,912,309
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Akr1b7
aldo-keto reductase family 1, member B7
increases expression
EXP
GW 4064 results in increased expression of AKR1B7 mRNA
CTD
PMID:26655953
NCBI chr 6:34,389,297...34,400,072
Ensembl chr 6:34,389,269...34,400,077
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Aldh2
aldehyde dehydrogenase 2, mitochondrial
decreases expression
EXP
GW 4064 results in decreased expression of ALDH2 protein
CTD
PMID:23178280
NCBI chr 5:121,704,090...121,731,887
Ensembl chr 5:121,704,090...121,731,887
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Alpl
alkaline phosphatase, liver/bone/kidney
increases expression
EXP
GW 4064 results in increased expression of ALPL mRNA
CTD
PMID:26655953
NCBI chr 4:137,469,042...137,523,695
Ensembl chr 4:137,469,044...137,523,695
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Alppl2
alkaline phosphatase, placental-like 2
increases expression
EXP
GW 4064 results in increased expression of ALPPL2 mRNA
CTD
PMID:26655953
NCBI chr 1:87,014,412...87,023,656
Ensembl chr 1:87,014,416...87,017,650
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Ang
angiogenin, ribonuclease, RNase A family, 5
increases expression
EXP
GW 4064 results in increased expression of ANG mRNA
CTD
PMID:26655953
NCBI chr14:51,328,607...51,339,462
Ensembl chr14:51,328,607...51,339,466
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Ang2
angiogenin, ribonuclease A family, member 2
increases expression
EXP
GW 4064 results in increased expression of ANG2 mRNA
CTD
PMID:26655953
NCBI chr14:51,432,781...51,436,400
Ensembl chr14:51,432,781...51,436,605
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Ang3
angiogenin, ribonuclease A family, member 3
increases expression
EXP
GW 4064 results in increased expression of ANG3 mRNA
CTD
PMID:26655953
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Ang4
angiogenin, ribonuclease A family, member 4
increases expression
EXP
GW 4064 results in increased expression of ANG4 mRNA
CTD
PMID:26655953
NCBI chr14:52,001,349...52,011,047
Ensembl chr14:52,001,335...52,011,047
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Ankrd34b
ankyrin repeat domain 34B
decreases expression
EXP
GW 4064 results in decreased expression of ANKRD34B mRNA
CTD
PMID:26655953
NCBI chr13:92,562,413...92,578,166
Ensembl chr13:92,562,404...92,578,166
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Ankrd65
ankyrin repeat domain 65
increases expression
EXP
GW 4064 results in increased expression of ANKRD65 mRNA
CTD
PMID:26655953
NCBI chr 4:155,875,432...155,884,132
Ensembl chr 4:155,874,896...155,877,659
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Anpep
alanyl aminopeptidase, membrane
increases expression
EXP
GW 4064 results in increased expression of ANPEP mRNA
CTD
PMID:26655953
NCBI chr 7:79,471,551...79,497,958
Ensembl chr 7:79,471,551...79,510,807
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Aoah
acyloxyacyl hydrolase
increases expression
EXP
GW 4064 results in increased expression of AOAH mRNA
CTD
PMID:26655953
NCBI chr13:20,978,273...21,220,787
Ensembl chr13:20,978,283...21,220,787
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Apoa1
apolipoprotein A-I
decreases expression increases expression multiple interactions
ISO EXP
GW 4064 results in decreased expression of APOA1 protein GW 4064 results in increased expression of APOA1 mRNA bisphenol A inhibits the reaction [GW 4064 results in increased expression of APOA1 mRNA]; GW 4064 inhibits the reaction [bisphenol A results in increased expression of APOA1 mRNA]; NR1H4 gene mutant form inhibits the reaction [GW 4064 results in increased expression of APOA1 mRNA]; Stigmasterol promotes the reaction [GW 4064 results in increased expression of APOA1 mRNA]
CTD
PMID:19445040 PMID:30245210
NCBI chr 9:46,139,928...46,141,767
Ensembl chr 9:46,139,878...46,141,764
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Apoa5
apolipoprotein A-V
increases expression multiple interactions
ISO
GW 4064 results in increased expression of APOA5 mRNA [GW 4064 co-treated with Oleic Acid] results in increased expression of APOA5 mRNA
CTD
PMID:30611723
NCBI chr 9:46,179,906...46,183,219
Ensembl chr 9:46,179,931...46,183,217
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Apob
apolipoprotein B
increases expression multiple interactions decreases expression
EXP ISO
GW 4064 results in increased expression of APOB mRNA [GW 4064 co-treated with Oleic Acid] results in decreased expression of APOB mRNA GW 4064 results in decreased expression of APOB mRNA
CTD
PMID:26655953 PMID:30611723
NCBI chr12:8,027,629...8,066,839
Ensembl chr12:8,027,648...8,066,835
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Apobec2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2
increases expression
EXP
GW 4064 results in increased expression of APOBEC2 mRNA
CTD
PMID:26655953
NCBI chr17:48,726,259...48,739,756
Ensembl chr17:48,726,259...48,739,958
G
Apoc4
apolipoprotein C-IV
increases expression multiple interactions
ISO
GW 4064 results in increased expression of APOC4 mRNA [GW 4064 co-treated with Oleic Acid] results in decreased expression of APOC4 mRNA
CTD
PMID:30611723
NCBI chr 7:19,412,009...19,415,385
Ensembl chr 7:19,412,008...19,415,404
G
Apoe
apolipoprotein E
multiple interactions increases expression
EXP ISO
GW 4064 promotes the reaction [NR1H4 protein binds to APOE gene] GW 4064 results in increased expression of APOE mRNA [GW 4064 co-treated with Oleic Acid] results in decreased expression of APOE mRNA
CTD
PMID:20091679 PMID:26655953 PMID:30611723
NCBI chr 7:19,430,169...19,434,326
Ensembl chr 7:19,430,034...19,433,113
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Apol9a
apolipoprotein L 9a
decreases expression
EXP
GW 4064 results in decreased expression of APOL9A mRNA
CTD
PMID:26655953
NCBI chr15:77,287,989...77,295,280
Ensembl chr15:77,287,989...77,295,335
G
Apom
apolipoprotein M
increases expression
EXP
GW 4064 results in increased expression of APOM mRNA
CTD
PMID:26655953
NCBI chr17:35,347,973...35,350,777
Ensembl chr17:35,347,973...35,351,026
G
Aqp1
aquaporin 1
increases expression
EXP
GW 4064 results in increased expression of AQP1 mRNA
CTD
PMID:26655953
NCBI chr 6:55,313,284...55,325,540
Ensembl chr 6:55,313,417...55,325,540
G
Arg2
arginase type II
decreases expression
EXP
GW 4064 results in decreased expression of ARG2 mRNA
CTD
PMID:26655953
NCBI chr12:79,177,562...79,203,075
Ensembl chr12:79,177,551...79,203,075
G
Asb2
ankyrin repeat and SOCS box-containing 2
increases expression
EXP
GW 4064 results in increased expression of ASB2 mRNA
CTD
PMID:26655953
NCBI chr12:103,287,401...103,322,260
Ensembl chr12:103,287,401...103,322,260
G
Asgr1
asialoglycoprotein receptor 1
decreases expression
ISO
GW 4064 results in decreased expression of ASGR1 mRNA
CTD
PMID:31437187
NCBI chr11:69,939,735...69,948,721
Ensembl chr11:69,944,911...69,948,720
G
Ass1
argininosuccinate synthetase 1
increases expression
EXP
GW 4064 results in increased expression of ASS1 mRNA
CTD
PMID:26655953
NCBI chr 2:31,360,282...31,410,682
Ensembl chr 2:31,360,219...31,410,684
G
Astn1
astrotactin 1
increases expression
EXP
GW 4064 results in increased expression of ASTN1 mRNA
CTD
PMID:26655953
NCBI chr 1:158,189,647...158,519,351
Ensembl chr 1:158,189,843...158,519,351
G
Atf6
activating transcription factor 6
multiple interactions
EXP
GW 4064 inhibits the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of ATF6 mRNA]
CTD
PMID:28223344
NCBI chr 1:170,532,026...170,696,414
Ensembl chr 1:170,532,243...170,695,340
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Atp1a4
ATPase, Na+/K+ transporting, alpha 4 polypeptide
increases expression
EXP
GW 4064 results in increased expression of ATP1A4 mRNA
CTD
PMID:26655953
NCBI chr 1:172,051,075...172,085,991
Ensembl chr 1:172,051,080...172,085,981
G
Atp6v0d2
ATPase, H+ transporting, lysosomal V0 subunit D2
decreases expression
EXP
GW 4064 results in decreased expression of ATP6V0D2 mRNA
CTD
PMID:26655953
NCBI chr 4:19,876,838...19,922,566
Ensembl chr 4:19,876,841...19,922,605
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Atp7b
ATPase, Cu++ transporting, beta polypeptide
multiple interactions
EXP
ATP7B protein affects the reaction [GW 4064 results in increased expression of ABCB11 mRNA]; ATP7B protein affects the reaction [GW 4064 results in increased expression of NR0B2 mRNA]; GW 4064 inhibits the reaction [ATP7B gene mutant form results in decreased expression of ABCB11 mRNA]; GW 4064 inhibits the reaction [ATP7B gene mutant form results in decreased expression of NR0B2 mRNA]
CTD
PMID:26241054
NCBI chr 8:22,482,799...22,550,347
Ensembl chr 8:22,482,801...22,550,321
G
B3gat2
beta-1,3-glucuronyltransferase 2
increases expression
EXP
GW 4064 results in increased expression of B3GAT2 mRNA
CTD
PMID:26655953
NCBI chr 1:23,801,007...23,886,946
Ensembl chr 1:23,800,834...23,888,239
G
Baat
bile acid-Coenzyme A: amino acid N-acyltransferase
increases expression
EXP
GW 4064 results in increased expression of BAAT mRNA
CTD
PMID:26655953
NCBI chr 4:49,489,416...49,507,915
Ensembl chr 4:49,489,422...49,506,557
G
Bccip
BRCA2 and CDKN1A interacting protein
multiple interactions
EXP
GW 4064 promotes the reaction [NR1H4 protein binds to BCCIP gene]
CTD
PMID:20091679
NCBI chr 7:133,311,045...133,322,874
Ensembl chr 7:133,311,062...133,322,874
G
Bub1
BUB1, mitotic checkpoint serine/threonine kinase
increases expression
ISO
GW 4064 results in increased expression of BUB1 mRNA
CTD
PMID:31437187
NCBI chr 2:127,642,117...127,673,790
Ensembl chr 2:127,643,036...127,673,785
G
Bub1b
BUB1B, mitotic checkpoint serine/threonine kinase
increases expression
ISO
GW 4064 results in increased expression of BUB1B mRNA
CTD
PMID:31437187
NCBI chr 2:118,428,684...118,472,073
Ensembl chr 2:118,428,692...118,472,072
G
C1qtnf3
C1q and tumor necrosis factor related protein 3
increases expression
EXP
GW 4064 results in increased expression of C1QTNF3 mRNA
CTD
PMID:26655953
NCBI chr15:10,952,418...10,980,248
Ensembl chr15:10,952,418...10,980,236
G
C3
complement component 3
increases expression
EXP
GW 4064 results in increased expression of C3 mRNA
CTD
PMID:26655953
NCBI chr17:57,510,967...57,535,136
Ensembl chr17:57,510,970...57,535,136
G
C4bp
complement component 4 binding protein
decreases expression
EXP
GW 4064 results in decreased expression of C4BP mRNA
CTD
PMID:26655953
NCBI chr 1:130,562,510...130,589,365
Ensembl chr 1:130,562,510...130,589,369
G
Cabp4
calcium binding protein 4
increases expression
EXP
GW 4064 results in increased expression of CABP4 mRNA
CTD
PMID:26655953
NCBI chr19:4,185,422...4,189,608
Ensembl chr19:4,185,422...4,194,032
G
Cadps2
Ca2+-dependent activator protein for secretion 2
increases expression
EXP
GW 4064 results in increased expression of CADPS2 mRNA
CTD
PMID:26655953
NCBI chr 6:23,262,765...23,840,662
Ensembl chr 6:23,262,772...23,839,420
G
Calcr
calcitonin receptor
decreases expression
EXP
GW 4064 results in decreased expression of CALCR mRNA
CTD
PMID:26655953
NCBI chr 6:3,685,678...3,764,713
Ensembl chr 6:3,685,680...3,764,714
G
Camk1g
calcium/calmodulin-dependent protein kinase I gamma
increases expression
EXP
GW 4064 results in increased expression of CAMK1G mRNA
CTD
PMID:26655953
NCBI chr 1:193,028,654...193,052,636
Ensembl chr 1:193,028,654...193,052,606
G
Caprin1
cell cycle associated protein 1
multiple interactions
EXP
GW 4064 promotes the reaction [NR1H4 protein binds to CAPRIN1 gene]
CTD
PMID:20091679
NCBI chr 2:103,593,292...103,627,946
Ensembl chr 2:103,593,286...103,627,994
G
Casp1
caspase 1
multiple interactions
EXP
GW 4064 inhibits the reaction [[triptolide co-treated with TNF protein] results in increased cleavage of CASP1 protein]
CTD
PMID:36328986
NCBI chr 9:5,298,517...5,307,281
Ensembl chr 9:5,298,508...5,307,290
G
Casp12
caspase 12
decreases expression
EXP
GW 4064 results in decreased expression of CASP12 mRNA
CTD
PMID:26655953
NCBI chr 9:5,345,419...5,373,034
Ensembl chr 9:5,345,430...5,373,032
G
Casp4
caspase 4, apoptosis-related cysteine peptidase
multiple interactions
EXP
GW 4064 inhibits the reaction [[triptolide co-treated with Lipopolysaccharides] results in increased cleavage of CASP4 protein]
CTD
PMID:36328986
NCBI chr 9:5,308,816...5,336,791
Ensembl chr 9:5,308,828...5,336,783
G
Cckar
cholecystokinin A receptor
increases expression
EXP
GW 4064 results in increased expression of CCKAR mRNA
CTD
PMID:26655953
NCBI chr 5:53,855,827...53,865,046
Ensembl chr 5:53,855,118...53,865,047
G
Ccl2
C-C motif chemokine ligand 2
decreases expression increases expression
EXP
GW 4064 results in decreased expression of CCL2 mRNA GW 4064 results in increased expression of CCL2 mRNA
CTD
PMID:23371517 PMID:26655953
NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279
G
Ccl7
C-C motif chemokine ligand 7
increases expression
EXP
GW 4064 results in increased expression of CCL7 mRNA
CTD
PMID:26655953
NCBI chr11:81,936,538...81,938,351
Ensembl chr11:81,936,538...81,938,351
G
Ccna2
cyclin A2
increases expression
ISO
GW 4064 results in increased expression of CCNA2 mRNA
CTD
PMID:31437187
NCBI chr 3:36,619,014...36,627,187
Ensembl chr 3:36,619,014...36,626,299
G
Ccnb1
cyclin B1
increases expression
ISO
GW 4064 results in increased expression of CCNB1 mRNA
CTD
PMID:31437187
NCBI chr13:100,915,247...100,922,994
Ensembl chr13:100,915,158...100,923,078
G
Ccnd1
cyclin D1
increases expression
ISO
GW 4064 results in increased expression of CCND1 mRNA
CTD
PMID:31437187
NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662
G
Ccne1
cyclin E1
increases expression
ISO
GW 4064 results in increased expression of CCNE1 mRNA
CTD
PMID:31437187
NCBI chr 7:37,797,409...37,806,915
Ensembl chr 7:37,797,409...37,806,959
G
Ccne2
cyclin E2
increases expression
ISO
GW 4064 results in increased expression of CCNE2 mRNA
CTD
PMID:31437187
NCBI chr 4:11,190,489...11,204,781
Ensembl chr 4:11,191,351...11,204,779
G
Cd36
CD36 molecule
multiple interactions decreases expression
EXP ISO
GW 4064 inhibits the reaction [Oleic Acid results in increased expression of CD36 protein] GW 4064 results in decreased expression of CD36 mRNA; GW 4064 results in decreased expression of CD36 protein [GW 4064 co-treated with Oleic Acid] results in increased expression of CD36 mRNA
CTD
PMID:23371517 PMID:30611723
NCBI chr 5:17,986,680...18,093,828
Ensembl chr 5:17,986,688...18,093,799
G
Cd68
CD68 antigen
decreases expression
EXP
GW 4064 results in decreased expression of CD68 mRNA
CTD
PMID:23371517
NCBI chr11:69,555,039...69,556,996
Ensembl chr11:69,555,039...69,556,979
G
Cd72
CD72 antigen
increases expression
EXP
GW 4064 results in increased expression of CD72 mRNA
CTD
PMID:26655953
NCBI chr 4:43,447,724...43,454,708
Ensembl chr 4:43,446,462...43,454,628
G
Cd83
CD83 antigen
increases expression
EXP
GW 4064 results in increased expression of CD83 mRNA
CTD
PMID:26655953
NCBI chr13:43,938,661...43,956,608
Ensembl chr13:43,938,251...43,956,608
G
Cdc20
cell division cycle 20
increases expression
ISO
GW 4064 results in increased expression of CDC20 mRNA
CTD
PMID:31437187
NCBI chr 4:118,290,098...118,294,540
Ensembl chr 4:118,290,098...118,294,549
G
Cdc25c
cell division cycle 25C
increases expression
ISO
GW 4064 results in increased expression of CDC25C mRNA
CTD
PMID:31437187
NCBI chr18:34,866,046...34,884,644
Ensembl chr18:34,866,046...34,884,586
G
Cdc45
cell division cycle 45
increases expression
ISO
GW 4064 results in increased expression of CDC45 mRNA
CTD
PMID:31437187
NCBI chr16:18,599,202...18,632,371
Ensembl chr16:18,599,197...18,630,737
G
Cdc6
cell division cycle 6
increases expression
ISO
GW 4064 results in increased expression of CDC6 mRNA
CTD
PMID:31437187
NCBI chr11:98,798,627...98,814,768
Ensembl chr11:98,798,627...98,814,766
G
Cdc7
cell division cycle 7
increases expression
ISO
GW 4064 results in increased expression of CDC7 mRNA
CTD
PMID:31437187
NCBI chr 5:107,112,201...107,132,298
Ensembl chr 5:107,112,188...107,132,298
G
Cdh17
cadherin 17
decreases expression
EXP
GW 4064 results in decreased expression of CDH17 mRNA
CTD
PMID:26655953
NCBI chr 4:11,758,157...11,817,905
Ensembl chr 4:11,758,147...11,817,895
G
Cdhr2
cadherin-related family member 2
increases expression
EXP
GW 4064 results in increased expression of CDHR2 mRNA
CTD
PMID:26655953
NCBI chr13:54,849,276...54,884,475
Ensembl chr13:54,849,274...54,884,475
G
Cdk1
cyclin dependent kinase 1
increases expression
ISO
GW 4064 results in increased expression of CDK1 mRNA
CTD
PMID:31437187
NCBI chr10:69,170,976...69,188,742
Ensembl chr10:69,170,976...69,188,768
G
Cdk2
cyclin dependent kinase 2
increases expression
ISO
GW 4064 results in increased expression of CDK2 mRNA
CTD
PMID:31437187
NCBI chr10:128,533,807...128,540,920
Ensembl chr10:128,533,808...128,540,900
G
Cdk5rap2
CDK5 regulatory subunit associated protein 2
multiple interactions
EXP
GW 4064 promotes the reaction [NR1H4 protein binds to CDK5RAP2 gene]
CTD
PMID:20091679
NCBI chr 4:70,135,092...70,328,672
Ensembl chr 4:70,135,093...70,328,680
G
Cdkn1a
cyclin dependent kinase inhibitor 1A
decreases expression
ISO
GW 4064 results in decreased expression of CDKN1A mRNA; GW 4064 results in decreased expression of CDKN1A protein
CTD
PMID:28496032
NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701
G
Cdkn2b
cyclin dependent kinase inhibitor 2B
decreases expression
ISO
GW 4064 results in decreased expression of CDKN2B mRNA
CTD
PMID:31437187
NCBI chr 4:89,224,526...89,229,269
Ensembl chr 4:89,224,536...89,229,276
G
Cdkn2c
cyclin dependent kinase inhibitor 2C
increases expression
ISO
GW 4064 results in increased expression of CDKN2C mRNA
CTD
PMID:31437187
NCBI chr 4:109,518,073...109,523,953
Ensembl chr 4:109,518,073...109,524,386
G
Cebpb
CCAAT/enhancer binding protein beta
multiple interactions
EXP
GW 4064 promotes the reaction [NR1H4 protein binds to CEBPB gene]
CTD
PMID:20091679
NCBI chr 2:167,530,835...167,532,352
Ensembl chr 2:167,530,835...167,532,338
G
Cers2
ceramide synthase 2
multiple interactions
EXP
GW 4064 inhibits the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of CERS2 mRNA]
CTD
PMID:28223344
NCBI chr 3:95,222,077...95,230,910
Ensembl chr 3:95,222,102...95,230,910
G
Cers4
ceramide synthase 4
multiple interactions
EXP
GW 4064 inhibits the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of CERS4 mRNA]
CTD
PMID:28223344
NCBI chr 8:4,542,863...4,579,603
Ensembl chr 8:4,543,026...4,581,680
G
Ces2b
carboxyesterase 2B
increases expression
EXP
GW 4064 results in increased expression of CES2B mRNA
CTD
PMID:26655953
NCBI chr 8:105,555,130...105,566,725
Ensembl chr 8:105,558,204...105,566,725
G
Ces2c
carboxylesterase 2C
increases expression
EXP
GW 4064 results in increased expression of CES2C mRNA
CTD
PMID:26655953
NCBI chr 8:105,573,700...105,581,115
Ensembl chr 8:105,573,700...105,581,115
G
Chek1
checkpoint kinase 1
increases expression
ISO
GW 4064 results in increased expression of CHEK1 mRNA
CTD
PMID:31437187
NCBI chr 9:36,619,935...36,637,897
Ensembl chr 9:36,619,778...36,638,361
G
Chek2
checkpoint kinase 2
increases expression
ISO
GW 4064 results in increased expression of CHEK2 mRNA
CTD
PMID:31437187
NCBI chr 5:110,987,668...111,022,006
Ensembl chr 5:110,987,845...111,022,011
G
Chrna7
cholinergic receptor, nicotinic, alpha polypeptide 7
decreases expression
EXP
GW 4064 results in decreased expression of CHRNA7 mRNA
CTD
PMID:26655953
NCBI chr 7:62,748,440...62,862,274
Ensembl chr 7:62,748,440...62,862,317
G
Chst13
carbohydrate sulfotransferase 13
increases expression
EXP
GW 4064 results in increased expression of CHST13 mRNA
CTD
PMID:26655953
NCBI chr 6:90,285,333...90,302,167
Ensembl chr 6:90,285,331...90,302,167
G
Cks2
CDC28 protein kinase regulatory subunit 2
multiple interactions
EXP
GW 4064 promotes the reaction [NR1H4 protein binds to CKS2 gene]
CTD
PMID:20091679
NCBI chr13:51,799,268...51,804,698
Ensembl chr13:51,799,268...51,804,696
G
Cldn11
claudin 11
decreases expression
EXP
GW 4064 results in decreased expression of CLDN11 mRNA
CTD
PMID:26655953
NCBI chr 3:31,204,069...31,218,475
Ensembl chr 3:31,204,069...31,218,473
G
Clec7a
C-type lectin domain family 7, member a
increases expression
EXP
GW 4064 results in increased expression of CLEC7A mRNA
CTD
PMID:26655953
NCBI chr 6:129,438,554...129,449,748
Ensembl chr 6:129,438,554...129,449,742
G
Clstn2
calsyntenin 2
decreases expression
EXP
GW 4064 results in decreased expression of CLSTN2 mRNA
CTD
PMID:26655953
NCBI chr 9:97,326,448...97,915,433
Ensembl chr 9:97,326,448...97,915,234
G
Cmah
cytidine monophospho-N-acetylneuraminic acid hydroxylase
increases expression
EXP
GW 4064 results in increased expression of CMAH mRNA
CTD
PMID:26655953
NCBI chr13:24,511,387...24,661,272
Ensembl chr13:24,511,387...24,661,360
G
Cmpk2
cytidine/uridine monophosphate kinase 2
decreases expression
EXP
GW 4064 results in decreased expression of CMPK2 mRNA
CTD
PMID:26655953
NCBI chr12:26,519,121...26,529,836
Ensembl chr12:26,519,203...26,529,836
G
Cndp1
carnosine dipeptidase 1
increases expression
EXP
GW 4064 results in increased expression of CNDP1 mRNA
CTD
PMID:26655953
NCBI chr18:84,628,509...84,668,359
Ensembl chr18:84,628,634...84,668,220
G
Cnnm1
cyclin M1
increases expression
EXP
GW 4064 results in increased expression of CNNM1 mRNA
CTD
PMID:26655953
NCBI chr19:43,427,508...43,485,649
Ensembl chr19:43,428,875...43,485,649
G
Cnnm3
cyclin M3
multiple interactions
EXP
GW 4064 promotes the reaction [NR1H4 protein binds to CNNM3 gene]
CTD
PMID:20091679
NCBI chr 1:36,550,948...36,567,318
Ensembl chr 1:36,550,948...36,567,318
G
Cntfr
ciliary neurotrophic factor receptor
increases expression
EXP
GW 4064 results in increased expression of CNTFR mRNA
CTD
PMID:26655953
NCBI chr 4:41,657,498...41,697,091
Ensembl chr 4:41,657,498...41,697,089
G
Col16a1
collagen, type XVI, alpha 1
increases expression
EXP
GW 4064 results in increased expression of COL16A1 mRNA
CTD
PMID:26655953
NCBI chr 4:129,941,638...129,993,070
Ensembl chr 4:129,941,633...129,993,076
G
Col1a1
collagen, type I, alpha 1
decreases expression
ISO
GW 4064 results in decreased expression of COL1A1 mRNA
CTD
PMID:15980055
NCBI chr11:94,827,050...94,843,868
Ensembl chr11:94,827,050...94,843,868
G
Cox10
heme A:farnesyltransferase cytochrome c oxidase assembly factor 10
multiple interactions
ISO
[GW 4064 co-treated with Oleic Acid] results in decreased expression of COX10 mRNA
CTD
PMID:30611723
NCBI chr11:63,853,453...63,970,298
Ensembl chr11:63,853,453...63,970,294
G
Cpt1a
carnitine palmitoyltransferase 1a, liver
multiple interactions
ISO
[GW 4064 co-treated with Oleic Acid] results in decreased expression of CPT1A mRNA
CTD
PMID:30611723
NCBI chr19:3,372,328...3,435,735
Ensembl chr19:3,372,334...3,435,733
G
Cpt2
carnitine palmitoyltransferase 2
multiple interactions
ISO
[GW 4064 co-treated with Oleic Acid] results in decreased expression of CPT2 mRNA
CTD
PMID:30611723
NCBI chr 4:107,761,179...107,780,786
Ensembl chr 4:107,761,178...107,780,807
G
Crabp1
cellular retinoic acid binding protein I
increases expression
EXP
GW 4064 results in increased expression of CRABP1 mRNA
CTD
PMID:26655953
NCBI chr 9:54,672,032...54,680,394
Ensembl chr 9:54,672,032...54,680,394
G
Crct1
cysteine-rich C-terminal 1
decreases expression
EXP
GW 4064 results in decreased expression of CRCT1 mRNA
CTD
PMID:26655953
NCBI chr 3:92,921,512...92,922,993
Ensembl chr 3:92,921,512...92,922,994
G
Crispld2
cysteine-rich secretory protein LCCL domain containing 2
decreases expression
EXP
GW 4064 results in decreased expression of CRISPLD2 mRNA
CTD
PMID:26655953
NCBI chr 8:120,719,177...120,779,533
Ensembl chr 8:120,719,177...120,779,532
G
Crygs
crystallin, gamma S
increases expression
EXP
GW 4064 results in increased expression of CRYGS mRNA
CTD
PMID:26655953
NCBI chr16:22,623,953...22,630,160
Ensembl chr16:22,623,953...22,630,327
G
Csf1
colony stimulating factor 1 (macrophage)
increases expression
ISO
GW 4064 results in increased expression of CSF1 mRNA
CTD
PMID:31437187
NCBI chr 3:107,648,364...107,668,048
Ensembl chr 3:107,648,364...107,667,785
G
Csf1r
colony stimulating factor 1 receptor
increases expression
EXP
GW 4064 results in increased expression of CSF1R mRNA
CTD
PMID:26655953
NCBI chr18:61,238,644...61,264,211
Ensembl chr18:61,233,670...61,265,221
G
Csf2
colony stimulating factor 2 (granulocyte-macrophage)
increases expression
EXP ISO
GW 4064 results in increased expression of CSF2 mRNA
CTD
PMID:26655953 PMID:31437187
NCBI chr11:54,138,096...54,140,725
Ensembl chr11:54,138,097...54,140,493
G
Cst13
cystatin 13
increases expression
EXP
GW 4064 results in increased expression of CST13 mRNA
CTD
PMID:26655953
NCBI chr 2:148,661,989...148,672,328
Ensembl chr 2:148,662,001...148,672,330
G
Cubn
cubilin
increases expression
EXP
GW 4064 results in increased expression of CUBN mRNA
CTD
PMID:26655953
NCBI chr 2:13,281,149...13,496,687
Ensembl chr 2:13,281,149...13,496,624
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Cxcl15
C-X-C motif chemokine ligand 15
increases expression
EXP
GW 4064 results in increased expression of CXCL5 mRNA
CTD
PMID:26655953
NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926
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Cyp24a1
cytochrome P450, family 24, subfamily a, polypeptide 1
increases expression
EXP
GW 4064 results in increased expression of CYP24A1 mRNA
CTD
PMID:26655953
NCBI chr 2:170,324,877...170,339,065
Ensembl chr 2:170,324,628...170,339,065
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Cyp27a1
cytochrome P450, family 27, subfamily a, polypeptide 1
increases expression
EXP
GW 4064 results in increased expression of CYP27A1 mRNA
CTD
PMID:27609522
NCBI chr 1:74,752,311...74,777,056
Ensembl chr 1:74,752,733...74,777,051
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Cyp2b10
cytochrome P450, family 2, subfamily b, polypeptide 10
decreases expression multiple interactions
ISO
GW 4064 results in decreased expression of CYP2B6 mRNA [GW 4064 co-treated with Oleic Acid] results in decreased expression of CYP2B6 mRNA
CTD
PMID:30611723
NCBI chr 7:25,597,083...25,626,049
Ensembl chr 7:25,597,045...25,626,049
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Cyp2d26
cytochrome P450, family 2, subfamily d, polypeptide 26
increases expression
EXP
GW 4064 results in increased expression of CYP2D26 mRNA
CTD
PMID:26655953
NCBI chr15:82,674,308...82,678,653
Ensembl chr15:82,674,302...82,678,495
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Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
multiple interactions decreases expression
ISO
[GW 4064 co-treated with Oleic Acid] results in decreased expression of CYP2E1 mRNA GW 4064 results in decreased expression of CYP2E1 mRNA
CTD
PMID:30611723
NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900
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Cyp2j11
cytochrome P450, family 2, subfamily j, polypeptide 11
increases expression
EXP
GW 4064 results in increased expression of CYP2J11 mRNA
CTD
PMID:26655953
NCBI chr 4:96,182,745...96,236,930
Ensembl chr 4:96,182,745...96,236,899
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Cyp2j13
cytochrome P450, family 2, subfamily j, polypeptide 13
decreases expression
EXP
GW 4064 results in decreased expression of CYP2J13 mRNA
CTD
PMID:26655953
NCBI chr 4:95,930,897...95,965,803
Ensembl chr 4:95,915,771...95,965,783
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Cyp2j5
cytochrome P450, family 2, subfamily j, polypeptide 5
increases expression
EXP
GW 4064 results in increased expression of CYP2J5 mRNA
CTD
PMID:26655953
NCBI chr 4:96,517,010...96,552,391
Ensembl chr 4:96,517,010...96,552,391
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Cyp4a10
cytochrome P450, family 4, subfamily a, polypeptide 10
increases expression
EXP
GW 4064 results in increased expression of CYP4A10 mRNA
CTD
PMID:26655953
NCBI chr 4:115,375,484...115,390,846
Ensembl chr 4:115,375,461...115,390,846
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Cyp4a12a
cytochrome P450, family 4, subfamily a, polypeptide 12a
increases expression
EXP
GW 4064 results in increased expression of CYP4A12A mRNA
CTD
PMID:26655953
NCBI chr 4:115,156,243...115,190,012
Ensembl chr 4:115,156,243...115,190,012
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Cyp4a12b
cytochrome P450, family 4, subfamily a, polypeptide 12B
increases expression
EXP
GW 4064 results in increased expression of CYP4A12B mRNA
CTD
PMID:26655953
NCBI chr 4:115,268,821...115,296,231
Ensembl chr 4:115,268,821...115,296,231
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Cyp4a31
cytochrome P450, family 4, subfamily a, polypeptide 31
increases expression
EXP
GW 4064 results in increased expression of CYP4A31 mRNA
CTD
PMID:26655953
NCBI chr 4:115,420,824...115,436,212
Ensembl chr 4:115,420,846...115,436,212
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Cyp7a1
cytochrome P450, family 7, subfamily a, polypeptide 1
multiple interactions decreases expression
EXP ISO
[GW 4064 binds to and results in increased activity of NR1H4 protein] which results in decreased expression of CYP7A1 mRNA; [GW 4064 results in increased activity of NR1H4 protein] which results in decreased expression of CYP7A1 mRNA; FGFR4 protein affects the reaction [[GW 4064 results in increased activity of NR1H4 protein] which results in decreased expression of CYP7A1 mRNA]; GW 4064 inhibits the reaction [Oleanolic Acid results in decreased expression of CYP7A1 mRNA]; GW 4064 inhibits the reaction [Oleanolic Acid results in decreased expression of CYP7A1 protein]; systhane inhibits the reaction [GW 4064 results in decreased expression of CYP7A1 mRNA]
CTD
PMID:14623915 PMID:15644430 PMID:22467244 PMID:22540009 PMID:27609522 PMID:31437187 PMID:36511616 PMID:37028458 More...
NCBI chr 4:6,265,612...6,275,632
Ensembl chr 4:6,265,612...6,275,633
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Cyp8b1
cytochrome P450, family 8, subfamily b, polypeptide 1
decreases expression multiple interactions
ISO EXP
GW 4064 results in decreased expression of CYP8B1 mRNA GW 4064 inhibits the reaction [Oleanolic Acid results in decreased expression of CYP8B1 mRNA]; GW 4064 inhibits the reaction [Oleanolic Acid results in decreased expression of CYP8B1 protein]
CTD
PMID:14623915 PMID:15644430 PMID:37028458
NCBI chr 9:121,743,422...121,745,371
Ensembl chr 9:121,743,422...121,745,371
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Cysltr1
cysteinyl leukotriene receptor 1
decreases expression
EXP
GW 4064 results in decreased expression of CYSLTR1 mRNA
CTD
PMID:26655953
NCBI chr X:105,617,952...105,647,329
Ensembl chr X:105,617,952...105,647,285
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Dbf4
DBF4 zinc finger
increases expression
ISO
GW 4064 results in increased expression of DBF4 mRNA
CTD
PMID:31437187
NCBI chr 5:8,446,969...8,472,789
Ensembl chr 5:8,446,973...8,472,716
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Ddit3
DNA-damage inducible transcript 3
multiple interactions
EXP
GW 4064 inhibits the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of DDIT3 mRNA]
CTD
PMID:28223344
NCBI chr10:127,126,662...127,132,160
Ensembl chr10:127,126,643...127,132,157 Ensembl chr10:127,126,643...127,132,157
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Ddx43
DEAD box helicase 43
decreases expression
EXP
GW 4064 results in decreased expression of DDX43 mRNA
CTD
PMID:26655953
NCBI chr 9:78,303,059...78,330,871
Ensembl chr 9:78,303,059...78,330,869
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Decr1
2,4-dienoyl CoA reductase 1, mitochondrial
multiple interactions
ISO
[GW 4064 co-treated with Oleic Acid] results in decreased expression of DECR1 mRNA
CTD
PMID:30611723
NCBI chr 4:15,917,240...15,945,377
Ensembl chr 4:15,917,240...15,945,507
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Degs2
delta 4-desaturase, sphingolipid 2
multiple interactions
EXP
GW 4064 inhibits the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of DEGS2 mRNA]
CTD
PMID:28223344
NCBI chr12:108,653,051...108,668,561
Ensembl chr12:108,644,970...108,668,570
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Dgat1
diacylglycerol O-acyltransferase 1
multiple interactions decreases expression
ISO
[GW 4064 co-treated with Oleic Acid] results in decreased expression of DGAT1 mRNA GW 4064 results in decreased expression of DGAT1 mRNA
CTD
PMID:30611723
NCBI chr15:76,386,215...76,396,167
Ensembl chr15:76,386,215...76,396,153
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Dgat2
diacylglycerol O-acyltransferase 2
multiple interactions decreases expression
ISO
[GW 4064 co-treated with Oleic Acid] results in decreased expression of DGAT2 mRNA GW 4064 results in decreased expression of DGAT2 mRNA
CTD
PMID:30611723
NCBI chr 7:98,802,870...98,831,920
Ensembl chr 7:98,802,865...98,831,926
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Dhdds
dehydrodolichyl diphosphate synthase
multiple interactions increases expression
ISO
[GW 4064 co-treated with Oleic Acid] results in decreased expression of DHDDS mRNA GW 4064 results in increased expression of DHDDS mRNA
CTD
PMID:30611723
NCBI chr 4:133,696,339...133,728,267
Ensembl chr 4:133,696,339...133,728,229
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Dio1
deiodinase, iodothyronine, type I
decreases expression
EXP
GW 4064 results in decreased expression of DIO1 mRNA
CTD
PMID:26655953
NCBI chr 4:107,148,662...107,164,365
Ensembl chr 4:107,148,662...107,164,366
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Dlgap3
DLG associated protein 3
increases expression
EXP
GW 4064 results in increased expression of DLGAP3 mRNA
CTD
PMID:26655953
NCBI chr 4:127,062,090...127,130,815
Ensembl chr 4:127,062,997...127,130,815
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Dmc1
DNA meiotic recombinase 1
increases expression
EXP
GW 4064 results in increased expression of DMC1 mRNA
CTD
PMID:26655953
NCBI chr15:79,445,698...79,489,362
Ensembl chr15:79,445,698...79,489,310
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Dnaaf6
dynein axonemal assembly factor 6
increases expression
EXP
GW 4064 results in increased expression of DNAAF6 mRNA
CTD
PMID:26655953
NCBI chr X:138,963,628...139,007,546
Ensembl chr X:138,963,628...139,007,546
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Dnah1
dynein, axonemal, heavy chain 1
increases expression
EXP
GW 4064 results in increased expression of DNAH1 mRNA
CTD
PMID:26655953
NCBI chr14:30,982,332...31,045,926
Ensembl chr14:30,982,332...31,045,853
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Dnase1
deoxyribonuclease I
increases expression
EXP
GW 4064 results in increased expression of DNASE1 mRNA
CTD
PMID:26655953
NCBI chr16:3,855,007...3,857,888
Ensembl chr16:3,854,806...3,857,888
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Dnph1
2'-deoxynucleoside 5'-phosphate N-hydrolase 1
increases expression
EXP
GW 4064 results in increased expression of DNPH1 mRNA
CTD
PMID:26655953
NCBI chr17:46,807,715...46,810,544
Ensembl chr17:46,807,637...46,810,550
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Dock2
dedicator of cyto-kinesis 2
decreases expression
EXP
GW 4064 results in decreased expression of DOCK2 mRNA
CTD
PMID:26655953
NCBI chr11:34,176,815...34,674,732
Ensembl chr11:34,176,815...34,674,719
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Dusp26
dual specificity phosphatase 26
increases expression
EXP
GW 4064 results in increased expression of DUSP26 mRNA
CTD
PMID:26655953
NCBI chr 8:31,579,555...31,587,074
Ensembl chr 8:31,579,499...31,587,075
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Duxbl1
double homeobox B-like 1
decreases expression
EXP
GW 4064 results in decreased expression of DUXBL1 mRNA
CTD
PMID:26655953
NCBI chr14:25,979,011...25,990,590
Ensembl chr14:25,979,001...25,990,512
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Ech1
enoyl coenzyme A hydratase 1, peroxisomal
multiple interactions
ISO
[GW 4064 co-treated with Oleic Acid] results in decreased expression of ECH1 mRNA
CTD
PMID:30611723
NCBI chr 7:28,524,763...28,531,664
Ensembl chr 7:28,524,642...28,531,672
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Echs1
enoyl Coenzyme A hydratase, short chain, 1, mitochondrial
multiple interactions
ISO
[GW 4064 co-treated with Oleic Acid] results in decreased expression of ECHS1 mRNA
CTD
PMID:30611723
NCBI chr 7:139,685,623...139,696,334
Ensembl chr 7:139,685,623...139,696,389
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Edn1
endothelin 1
decreases expression
ISO
GW 4064 results in decreased expression of EDN1 mRNA
CTD
PMID:16357303
NCBI chr13:42,454,952...42,461,466
Ensembl chr13:42,454,952...42,461,466
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Efcab10
EF-hand calcium binding domain 10
increases expression
EXP
GW 4064 results in increased expression of EFCAB10 mRNA
CTD
PMID:26655953
NCBI chr12:33,444,824...33,451,268
Ensembl chr12:33,444,853...33,451,266
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Egln3
egl-9 family hypoxia-inducible factor 3
decreases expression
EXP
GW 4064 results in decreased expression of EGLN3 mRNA
CTD
PMID:26655953
NCBI chr12:54,225,767...54,250,660
Ensembl chr12:54,225,767...54,250,646
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Ehhadh
enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase
multiple interactions
ISO
[GW 4064 co-treated with Oleic Acid] results in decreased expression of EHHADH mRNA
CTD
PMID:30611723
NCBI chr16:21,580,035...21,606,589
Ensembl chr16:21,580,037...21,606,557
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Elf5
E74-like factor 5
decreases expression
EXP
GW 4064 results in decreased expression of ELF5 mRNA
CTD
PMID:26655953
NCBI chr 2:103,242,443...103,281,334
Ensembl chr 2:103,242,033...103,281,334
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Ell2
elongation factor for RNA polymerase II 2
multiple interactions
EXP
GW 4064 promotes the reaction [NR1H4 protein binds to ELL2 gene]
CTD
PMID:20091679
NCBI chr13:75,855,603...75,920,480
Ensembl chr13:75,854,876...75,920,483
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Elovl1
ELOVL fatty acid elongase 1
increases expression
ISO
GW 4064 results in increased expression of ELOVL1 mRNA
CTD
PMID:30611723
NCBI chr 4:118,285,321...118,290,150
Ensembl chr 4:118,285,290...118,290,150
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Elovl5
ELOVL fatty acid elongase 5
multiple interactions
ISO
[GW 4064 co-treated with Oleic Acid] results in decreased expression of ELOVL5 mRNA
CTD
PMID:30611723
NCBI chr 9:77,824,647...77,891,801
Ensembl chr 9:77,824,646...77,891,801
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Elovl6
ELOVL fatty acid elongase 6
multiple interactions
ISO
[GW 4064 co-treated with Oleic Acid] results in decreased expression of ELOVL6 mRNA
CTD
PMID:30611723
NCBI chr 3:129,326,035...129,432,144
Ensembl chr 3:129,326,004...129,432,144
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Emid1
EMI domain containing 1
increases expression
EXP
GW 4064 results in increased expression of EMID1 mRNA
CTD
PMID:26655953
NCBI chr11:5,056,265...5,102,322
Ensembl chr11:5,056,265...5,102,257
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Eno1
enolase 1, alpha non-neuron
decreases expression
EXP
GW 4064 results in decreased expression of ENO1 protein
CTD
PMID:23178280
NCBI chr 4:150,321,165...150,333,336
Ensembl chr 4:150,321,178...150,333,336
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Enpp2
ectonucleotide pyrophosphatase/phosphodiesterase 2
decreases expression
EXP
GW 4064 results in decreased expression of ENPP2 mRNA
CTD
PMID:26655953
NCBI chr15:54,702,297...54,816,284
Ensembl chr15:54,702,297...54,816,288
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Enpp6
ectonucleotide pyrophosphatase/phosphodiesterase 6
increases expression
EXP
GW 4064 results in increased expression of ENPP6 mRNA
CTD
PMID:26655953
NCBI chr 8:47,439,920...47,549,797
Ensembl chr 8:47,439,922...47,549,797
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Epgn
epithelial mitogen
decreases expression
EXP
GW 4064 results in decreased expression of EPGN mRNA
CTD
PMID:26655953
NCBI chr 5:91,175,376...91,183,071
Ensembl chr 5:91,175,323...91,183,074
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Epha7
Eph receptor A7
increases expression
EXP
GW 4064 results in increased expression of EPHA7 mRNA
CTD
PMID:26655953
NCBI chr 4:28,811,840...28,969,391
Ensembl chr 4:28,813,131...28,967,499
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Eps8l3
EPS8-like 3
increases expression
EXP
GW 4064 results in increased expression of EPS8L3 mRNA
CTD
PMID:26655953
NCBI chr 3:107,781,177...107,800,216
Ensembl chr 3:107,784,545...107,800,216
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Erbb4
erb-b2 receptor tyrosine kinase 4
decreases expression
EXP
GW 4064 results in decreased expression of ERBB4 mRNA
CTD
PMID:26655953
NCBI chr 1:68,071,063...69,147,756
Ensembl chr 1:68,071,345...69,147,218
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Esam
endothelial cell-specific adhesion molecule
increases expression
EXP
GW 4064 results in increased expression of ESAM mRNA
CTD
PMID:26655953
NCBI chr 9:37,439,385...37,449,615
Ensembl chr 9:37,439,374...37,449,615
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Espl1
extra spindle pole bodies 1, separase
increases expression
ISO
GW 4064 results in increased expression of ESPL1 mRNA
CTD
PMID:31437187
NCBI chr15:102,204,688...102,232,792
Ensembl chr15:102,204,701...102,232,792
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Etnppl
ethanolamine phosphate phospholyase
increases expression
EXP
GW 4064 results in increased expression of ETNPPL mRNA
CTD
PMID:26655953
NCBI chr 3:130,411,097...130,429,399
Ensembl chr 3:130,411,097...130,431,170
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Fa2h
fatty acid 2-hydroxylase
decreases expression
EXP
GW 4064 results in decreased expression of FA2H mRNA
CTD
PMID:26655953
NCBI chr 8:112,071,770...112,120,453
Ensembl chr 8:112,071,767...112,120,456
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Fabp1
fatty acid binding protein 1, liver
decreases expression multiple interactions
ISO
GW 4064 results in decreased expression of FABP1 mRNA [GW 4064 co-treated with Oleic Acid] results in decreased expression of FABP1 mRNA
CTD
PMID:30611723
NCBI chr 6:71,176,863...71,182,018
Ensembl chr 6:71,176,811...71,182,007
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Fabp6
fatty acid binding protein 6
multiple interactions increases expression
EXP ISO
NR1H4 gene mutant form inhibits the reaction [GW 4064 results in increased expression of FABP6 mRNA]
CTD
PMID:22918042 PMID:26655953 PMID:35224661
NCBI chr11:43,486,867...43,492,389
Ensembl chr11:43,486,876...43,492,367
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Fam163a
family with sequence similarity 163, member A
decreases expression
EXP
GW 4064 results in decreased expression of FAM163A mRNA
CTD
PMID:26655953
NCBI chr 1:155,951,702...156,033,027
Ensembl chr 1:155,951,712...156,032,596
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Fam171a2
family with sequence similarity 171, member A2
decreases expression
EXP
GW 4064 results in decreased expression of FAM171A2 mRNA
CTD
PMID:26655953
NCBI chr11:102,327,807...102,338,551
Ensembl chr11:102,327,807...102,338,508
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Fas
Fas cell surface death receptor
decreases expression
ISO
GW 4064 results in decreased expression of FAS mRNA
CTD
PMID:14623915
NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172
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Fasn
fatty acid synthase
multiple interactions
ISO
[GW 4064 co-treated with Oleic Acid] results in decreased expression of FASN mRNA
CTD
PMID:30611723
NCBI chr11:120,696,784...120,715,992
Ensembl chr11:120,696,672...120,715,373
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Fbp2
fructose bisphosphatase 2
increases expression
EXP
GW 4064 results in increased expression of FBP2 mRNA
CTD
PMID:26655953
NCBI chr13:62,984,698...63,006,214
Ensembl chr13:62,984,691...63,006,236
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Fbxo40
F-box protein 40
increases expression
EXP
GW 4064 results in increased expression of FBXO40 mRNA
CTD
PMID:26655953
NCBI chr16:36,783,823...36,811,321
Ensembl chr16:36,783,822...36,810,829
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Fbxw15
F-box and WD-40 domain protein 15
decreases expression
EXP
GW 4064 results in decreased expression of FBXW15 mRNA
CTD
PMID:26655953
NCBI chr 9:109,381,670...109,397,330
Ensembl chr 9:109,381,670...109,397,330
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Fcna
ficolin A
multiple interactions
EXP
GW 4064 promotes the reaction [NR1H4 protein binds to FCNA gene]
CTD
PMID:20091679
NCBI chr 2:25,514,677...25,525,448
Ensembl chr 2:25,514,678...25,518,042
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Fdft1
farnesyl diphosphate farnesyl transferase 1
multiple interactions
ISO
[GW 4064 co-treated with Oleic Acid] results in decreased expression of FDFT1 mRNA
CTD
PMID:30611723
NCBI chr14:63,382,599...63,419,136
Ensembl chr14:63,382,599...63,417,027
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Fga
fibrinogen alpha chain
multiple interactions increases expression
EXP
GW 4064 promotes the reaction [NR1H4 protein binds to FGA gene] GW 4064 results in increased expression of FGA mRNA
CTD
PMID:20091679 PMID:26655953
NCBI chr 3:82,933,460...82,940,934
Ensembl chr 3:82,933,383...82,940,934
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Fgf15
fibroblast growth factor 15
increases expression multiple interactions
EXP ISO
GW 4064 results in increased expression of FGF15 mRNA; GW 4064 results in increased expression of FGF15 protein; GW 4064 results in increased expression of FGF19 mRNA; GW 4064 results in increased expression of FGF19 protein [GW 4064 co-treated with Dietary Fats] results in decreased expression of FGF15 mRNA; epiallopregnanolone sulfate inhibits the reaction [GW 4064 results in increased expression of FGF19 mRNA]; epiallopregnanolone sulfate inhibits the reaction [GW 4064 results in increased expression of FGF19 protein]; FGF15 gene mutant form inhibits the reaction [GW 4064 results in increased expression of ABCG5 mRNA]; FGF15 gene mutant form inhibits the reaction [GW 4064 results in increased expression of ABCG8 mRNA]; FGF15 gene mutant form inhibits the reaction [GW 4064 results in increased expression of SCARB1 mRNA]; GW 4064 inhibits the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of FGF15 mRNA]; GW 4064 promotes the reaction [NR1H4 protein binds to FGF15 gene]; NR1H4 gene mutant form inhibits the reaction [GW 4064 results in increased expression of FGF15 mRNA]; systhane inhibits the reaction [GW 4064 results in increased expression of FGF15 mRNA] [[GW 4064 results in increased activity of NR1H4 protein] which binds to FGF19 promoter] which results in increased expression of FGF19 mRNA; [GW 4064 results in increased activity of NR1H4 protein] which binds to FGF19 promoter
CTD
PMID:16269825 PMID:20091679 PMID:22561792 PMID:22918042 PMID:22961653 PMID:27609522 PMID:28223344 PMID:30996006 PMID:36511616 More...
NCBI chr 7:144,450,269...144,454,690
Ensembl chr 7:144,450,268...144,454,690
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Fgf21
fibroblast growth factor 21
increases expression
EXP
GW 4064 results in increased expression of FGF21 mRNA
CTD
PMID:26655953
NCBI chr 7:45,263,314...45,264,914
Ensembl chr 7:45,263,310...45,264,914
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Fgfr4
fibroblast growth factor receptor 4
multiple interactions
EXP
FGFR4 protein affects the reaction [[GW 4064 results in increased activity of NR1H4 protein] which results in decreased expression of CYP7A1 mRNA]
CTD
PMID:22467244
NCBI chr13:55,300,631...55,316,572
Ensembl chr13:55,300,453...55,316,572
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Flacc1
flagellum associated containing coiled-coil domains 1
increases expression
EXP
GW 4064 results in increased expression of FLACC1 mRNA
CTD
PMID:26655953
NCBI chr 1:58,696,085...58,735,167
Ensembl chr 1:58,686,062...58,735,148
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Fnta
farnesyltransferase, CAAX box, alpha
multiple interactions
ISO
[GW 4064 co-treated with Oleic Acid] results in decreased expression of FNTA mRNA
CTD
PMID:30611723
NCBI chr 8:26,488,716...26,505,638
Ensembl chr 8:26,488,750...26,505,678
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Fntb
farnesyltransferase, CAAX box, beta
multiple interactions
ISO
[GW 4064 co-treated with Oleic Acid] results in decreased expression of FNTB mRNA
CTD
PMID:30611723
NCBI chr12:76,884,014...76,968,188
Ensembl chr12:76,812,363...76,968,186
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Frzb
frizzled-related protein
decreases expression
EXP
GW 4064 results in decreased expression of FRZB mRNA
CTD
PMID:26655953
NCBI chr 2:80,242,314...80,277,740
Ensembl chr 2:80,242,314...80,277,969
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Fshr
follicle stimulating hormone receptor
multiple interactions decreases expression
EXP
bisphenol A inhibits the reaction [GW 4064 results in decreased expression of FSHR mRNA]; NR1H4 gene mutant form inhibits the reaction [GW 4064 results in decreased expression of FSHR mRNA]; Stigmasterol inhibits the reaction [GW 4064 results in decreased expression of FSHR mRNA]
CTD
PMID:30245210
NCBI chr17:89,292,380...89,508,103
Ensembl chr17:89,292,380...89,508,103
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Fst
follistatin
decreases expression
EXP
GW 4064 results in decreased expression of FST mRNA
CTD
PMID:26655953
NCBI chr13:114,588,798...114,595,522
Ensembl chr13:114,588,826...114,595,487
G
G6pc1
glucose-6-phosphatase catalytic subunit 1
decreases expression increases expression
EXP
GW 4064 results in decreased expression of G6PC1 mRNA GW 4064 results in increased expression of G6PC1 mRNA
CTD
PMID:23371517 PMID:26655953
NCBI chr11:101,258,542...101,268,729
Ensembl chr11:101,258,387...101,268,729
G
Gas7
growth arrest specific 7
increases expression
EXP
GW 4064 results in increased expression of GAS7 mRNA
CTD
PMID:26655953
NCBI chr11:67,344,083...67,579,818
Ensembl chr11:67,345,917...67,575,800
G
Gatd1
glutamine amidotransferase like class 1 domain containing 1
multiple interactions
EXP
GW 4064 promotes the reaction [NR1H4 protein binds to GATD1 gene]
CTD
PMID:20091679
NCBI chr 7:140,988,097...140,994,038
Ensembl chr 7:140,987,707...140,994,049
G
Gatm
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
increases expression
EXP
GW 4064 results in increased expression of GATM mRNA
CTD
PMID:26655953
NCBI chr 2:122,424,954...122,441,758
Ensembl chr 2:122,424,948...122,441,784
G
Gbp9
guanylate-binding protein 9
decreases expression
EXP
GW 4064 results in decreased expression of GBP6 mRNA
CTD
PMID:26655953
NCBI chr 5:105,224,331...105,258,255
Ensembl chr 5:105,225,496...105,287,405
G
Gchfr
GTP cyclohydrolase I feedback regulator
increases expression
EXP
GW 4064 results in increased expression of GCHFR mRNA
CTD
PMID:26655953
NCBI chr 2:118,998,269...119,002,870
Ensembl chr 2:118,998,254...119,002,871
G
Gclm
glutamate-cysteine ligase, modifier subunit
increases expression
EXP
GW 4064 results in increased expression of GCLM mRNA
CTD
PMID:26655953
NCBI chr 3:122,039,206...122,060,864
Ensembl chr 3:122,039,206...122,064,381
G
Gfra1
glial cell line derived neurotrophic factor family receptor alpha 1
decreases expression multiple interactions
EXP
GW 4064 results in decreased expression of GFRA1 mRNA bisphenol A inhibits the reaction [GW 4064 results in decreased expression of GFRA1 mRNA]; Stigmasterol inhibits the reaction [GW 4064 results in decreased expression of GFRA1 mRNA]
CTD
PMID:30245210
NCBI chr19:58,224,013...58,444,387
Ensembl chr19:58,224,036...58,444,341
G
Ggps1
geranylgeranyl diphosphate synthase 1
multiple interactions
ISO
[GW 4064 co-treated with Oleic Acid] results in decreased expression of GGPS1 mRNA
CTD
PMID:30611723
NCBI chr13:14,224,375...14,238,319
Ensembl chr13:14,225,244...14,238,073
G
Ggt1
gamma-glutamyltransferase 1
increases expression
EXP
GW 4064 results in increased expression of GGT1 mRNA
CTD
PMID:26655953
NCBI chr10:75,396,910...75,422,027
Ensembl chr10:75,397,438...75,422,034
G
Gimap1
GTPase, IMAP family member 1
increases expression
EXP
GW 4064 results in increased expression of GIMAP1 mRNA
CTD
PMID:26655953
NCBI chr 6:48,715,981...48,720,729
Ensembl chr 6:48,715,988...48,720,729
G
Gimap8
GTPase, IMAP family member 8
increases expression
EXP
GW 4064 results in increased expression of GIMAP8 mRNA
CTD
PMID:26655953
NCBI chr 6:48,624,120...48,637,809
Ensembl chr 6:48,624,168...48,637,809
G
Gimap9
GTPase, IMAP family member 9
increases expression
EXP
GW 4064 results in increased expression of GIMAP9 mRNA
CTD
PMID:26655953
NCBI chr 6:48,653,084...48,656,050
Ensembl chr 6:48,653,063...48,656,048
G
Gldc
glycine decarboxylase
increases expression
EXP
GW 4064 results in increased expression of GLDC mRNA
CTD
PMID:26655953
NCBI chr19:30,075,847...30,152,829
Ensembl chr19:30,075,847...30,152,829
G
Glipr2
GLI pathogenesis-related 2
increases expression
EXP
GW 4064 results in increased expression of GLIPR2 mRNA
CTD
PMID:26655953
NCBI chr 4:43,957,702...43,979,118
Ensembl chr 4:43,957,401...43,979,118
G
Glyctk
glycerate kinase
increases expression
EXP
GW 4064 results in increased expression of GLYCTK mRNA
CTD
PMID:26655953
NCBI chr 9:106,030,058...106,037,353
Ensembl chr 9:106,030,056...106,035,337
G
Gna14
guanine nucleotide binding protein, alpha 14
increases expression
EXP
GW 4064 results in increased expression of GNA14 mRNA
CTD
PMID:26655953
NCBI chr19:16,413,031...16,590,706
Ensembl chr19:16,413,126...16,588,184
G
Gnmt
glycine N-methyltransferase
multiple interactions decreases expression
EXP
NR0B2 protein promotes the reaction [GW 4064 results in decreased expression of GNMT mRNA]
CTD
PMID:29416063
NCBI chr17:47,036,590...47,040,091
Ensembl chr17:47,036,590...47,040,094
G
Gpat3
glycerol-3-phosphate acyltransferase 3
multiple interactions increases expression
ISO
[GW 4064 co-treated with Oleic Acid] results in decreased expression of GPAT3 mRNA GW 4064 results in increased expression of GPAT3 mRNA
CTD
PMID:30611723
NCBI chr 5:100,994,095...101,046,968
Ensembl chr 5:100,993,579...101,046,968
G
Gpat4
glycerol-3-phosphate acyltransferase 4
multiple interactions
ISO
[GW 4064 co-treated with Oleic Acid] results in decreased expression of GPAT4 mRNA
CTD
PMID:30611723
NCBI chr 8:23,661,281...23,698,469
Ensembl chr 8:23,661,281...23,698,362
G
Gpbp1
GC-rich promoter binding protein 1
multiple interactions
EXP
GW 4064 promotes the reaction [NR1H4 protein binds to GPBP1 gene]
CTD
PMID:20091679
NCBI chr13:111,562,214...111,626,658
Ensembl chr13:111,562,214...111,626,645
G
Gpr50
G-protein-coupled receptor 50
increases expression
EXP
GW 4064 results in increased expression of GPR50 mRNA
CTD
PMID:26655953
NCBI chr X:70,707,273...70,712,863
Ensembl chr X:70,707,273...70,712,863
G
Gpt
glutamic pyruvic transaminase, soluble
decreases activity multiple interactions
ISO EXP
GW 4064 results in decreased activity of GPT protein GW 4064 inhibits the reaction [Oleanolic Acid results in increased activity of GPT protein]
CTD
PMID:14623915 PMID:37028458
NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886
G
Gpx1
glutathione peroxidase 1
increases expression
EXP
GW 4064 results in increased expression of GPX1 mRNA
CTD
PMID:26655953
NCBI chr 9:108,216,279...108,217,541
Ensembl chr 9:108,216,102...108,217,542
G
Gsdmd
gasdermin D
multiple interactions
EXP
GW 4064 inhibits the reaction [[triptolide co-treated with TNF protein] results in increased cleavage of GSDMD protein]
CTD
PMID:36328986
NCBI chr15:75,733,990...75,739,257
Ensembl chr15:75,734,176...75,739,257
G
Gsn
gelsolin
increases expression
EXP
GW 4064 results in increased expression of GSN mRNA
CTD
PMID:26655953
NCBI chr 2:35,146,371...35,197,914
Ensembl chr 2:35,146,392...35,197,904
G
Gsr
glutathione reductase
increases expression
EXP
GW 4064 results in increased expression of GSR mRNA
CTD
PMID:26655953
NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191
G
Gsta3
glutathione S-transferase, alpha 3
increases expression
EXP
GW 4064 results in increased expression of GSTA1 mRNA
CTD
PMID:26655953
NCBI chr 1:21,310,837...21,335,885
Ensembl chr 1:21,310,813...21,335,885
G
Gsta5
glutathione S-transferase alpha 5
increases expression
EXP
GW 4064 results in increased expression of GSTA2 mRNA
CTD
PMID:26655953
NCBI chr 9:78,197,210...78,212,807
Ensembl chr 9:78,197,205...78,212,807
G
Gstm1
glutathione S-transferase, mu 1
increases expression
EXP
GW 4064 results in increased expression of GSTM1 mRNA
CTD
PMID:26655953
NCBI chr 3:107,919,566...107,925,289
Ensembl chr 3:107,919,571...107,925,289
G
Gstm5
glutathione S-transferase, mu 5
increases expression
EXP
GW 4064 results in increased expression of GSTM3 mRNA
CTD
PMID:26655953
NCBI chr 3:107,803,240...107,806,002
Ensembl chr 3:107,803,137...107,806,002
G
Gtf2a2
general transcription factor II A, 2
multiple interactions
EXP
GW 4064 promotes the reaction [NR1H4 protein binds to GTF2A2 gene]
CTD
PMID:20091679
NCBI chr 9:69,919,830...69,930,148
Ensembl chr 9:69,919,832...69,930,148
G
Gtsf1
gametocyte specific factor 1
decreases expression
EXP
GW 4064 results in decreased expression of GTSF1 mRNA
CTD
PMID:26655953
NCBI chr15:103,310,885...103,338,872
Ensembl chr15:103,310,832...103,338,897
G
H19
H19, imprinted maternally expressed transcript
decreases expression
EXP
GW 4064 results in decreased expression of H19 mRNA
CTD
PMID:26655953
NCBI chr 7:142,129,267...142,131,883
Ensembl chr 7:142,129,262...142,131,917
G
H2-Q10
histocompatibility 2, Q region locus 10
increases expression
EXP
GW 4064 results in increased expression of H2-Q10 mRNA
CTD
PMID:26655953
NCBI chr17:35,780,986...35,785,460
Ensembl chr17:35,780,986...35,785,460
G
Haao
3-hydroxyanthranilate 3,4-dioxygenase
decreases expression increases expression
EXP
GW 4064 results in decreased expression of HAAO protein GW 4064 results in increased expression of HAAO mRNA
CTD
PMID:23178280 PMID:26655953
NCBI chr17:84,138,777...84,157,589
Ensembl chr17:84,138,585...84,155,392
G
Hadh
hydroxyacyl-Coenzyme A dehydrogenase
multiple interactions
ISO
[GW 4064 co-treated with Oleic Acid] results in decreased expression of HADH mRNA
CTD
PMID:30611723
NCBI chr 3:131,027,068...131,065,750
Ensembl chr 3:131,027,068...131,065,750
G
Hadha
hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha
multiple interactions
ISO
[GW 4064 co-treated with Oleic Acid] results in decreased expression of HADHA mRNA
CTD
PMID:30611723
NCBI chr 5:30,324,421...30,359,978
Ensembl chr 5:30,323,302...30,360,160
G
Hes2
hes family bHLH transcription factor 2
decreases expression
EXP
GW 4064 results in decreased expression of HES2 mRNA
CTD
PMID:26655953
NCBI chr 4:152,243,324...152,246,926
Ensembl chr 4:152,243,324...152,246,926
G
Heyl
hairy/enhancer-of-split related with YRPW motif-like
increases expression
EXP
GW 4064 results in increased expression of HEYL mRNA
CTD
PMID:26655953
NCBI chr 4:123,127,349...123,143,663
Ensembl chr 4:123,127,349...123,143,668
G
Hgd
homogentisate 1, 2-dioxygenase
increases expression
EXP
GW 4064 results in increased expression of HGD mRNA
CTD
PMID:26655953
NCBI chr16:37,400,104...37,452,388
Ensembl chr16:37,400,515...37,452,382
G
Hhex
hematopoietically expressed homeobox
multiple interactions increases expression
EXP
NR1H4 mutant form inhibits the reaction [GW 4064 results in increased expression of HHEX mRNA]
CTD
PMID:19072826
NCBI chr19:37,423,289...37,429,179
Ensembl chr19:37,423,258...37,429,179
G
Hif1a
hypoxia inducible factor 1, alpha subunit
decreases expression
EXP
GW 4064 results in decreased expression of HIF1A mRNA
CTD
PMID:26655953
NCBI chr12:73,948,186...73,994,304
Ensembl chr12:73,948,149...73,994,304
G
Hif3a
hypoxia inducible factor 3, alpha subunit
decreases expression
EXP
GW 4064 results in decreased expression of HIF3A mRNA
CTD
PMID:26655953
NCBI chr 7:16,764,918...16,796,352
Ensembl chr 7:16,765,432...16,796,352
G
Hivep3
human immunodeficiency virus type I enhancer binding protein 3
increases expression
EXP
GW 4064 results in increased expression of HIVEP3 mRNA
CTD
PMID:26655953
NCBI chr 4:119,590,982...119,992,608
Ensembl chr 4:119,590,981...119,995,242
G
Hkdc1
hexokinase domain containing 1
decreases expression
EXP
GW 4064 results in decreased expression of HKDC1 mRNA
CTD
PMID:26655953
NCBI chr10:62,218,916...62,259,490
Ensembl chr10:62,218,916...62,258,270
G
Hmga1
high mobility group AT-hook 1
multiple interactions
EXP
GW 4064 promotes the reaction [NR1H4 protein binds to HMGA1 gene]
CTD
PMID:20091679
NCBI chr17:27,774,798...27,782,649
Ensembl chr17:27,775,471...27,782,648
G
Hmgcr
3-hydroxy-3-methylglutaryl-Coenzyme A reductase
increases expression
ISO
GW 4064 results in increased expression of HMGCR mRNA
CTD
PMID:30611723
NCBI chr13:96,785,470...96,807,444
Ensembl chr13:96,785,475...96,807,444
G
Hmgcs2
3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2
decreases expression
ISO
GW 4064 results in decreased expression of HMGCS2 mRNA
CTD
PMID:31437187
NCBI chr 3:98,187,747...98,218,054
Ensembl chr 3:98,187,751...98,218,054
G
Hnf4a
hepatic nuclear factor 4, alpha
increases expression decreases expression affects expression
EXP ISO
GW 4064 results in increased expression of HNF4A mRNA GW 4064 results in decreased expression of HNF4A mRNA GW 4064 affects the expression of HNF4A mRNA
CTD
PMID:26655953 PMID:31437187
NCBI chr 2:163,348,731...163,414,827
Ensembl chr 2:163,348,728...163,414,830
G
Hnf4aos
hepatic nuclear factor 4 alpha, opposite strand
increases expression
EXP
GW 4064 results in increased expression of HNF4AOS mRNA
CTD
PMID:26655953
NCBI chr 2:163,335,724...163,383,641
Ensembl chr 2:163,335,721...163,383,641
G
Hnmt
histamine N-methyltransferase
decreases expression
EXP
GW 4064 results in decreased expression of HNMT mRNA
CTD
PMID:26655953
NCBI chr 2:23,892,923...23,939,756
Ensembl chr 2:23,892,922...23,939,406
G
Homer2
homer scaffolding protein 2
increases expression
EXP
GW 4064 results in increased expression of HOMER2 mRNA
CTD
PMID:26655953
NCBI chr 7:81,250,229...81,356,673
Ensembl chr 7:81,250,229...81,357,275
G
Hrg
histidine-rich glycoprotein
decreases expression
EXP
GW 4064 results in decreased expression of HRG mRNA
CTD
PMID:26655953
NCBI chr16:22,769,822...22,780,409
Ensembl chr16:22,769,822...22,780,406
G
Hsd3b1
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
decreases expression
EXP
GW 4064 results in decreased expression of HSD3B2 mRNA
CTD
PMID:26655953
NCBI chr 3:98,749,672...98,767,110
Ensembl chr 3:98,759,510...98,767,110
G
Hsd3b3
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 3
increases expression
EXP
GW 4064 results in increased expression of HSD3B3 mRNA
CTD
PMID:26655953
NCBI chr 3:98,648,792...98,672,465
Ensembl chr 3:98,648,839...98,670,443
G
Hsd3b4
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 4
decreases expression
EXP
GW 4064 results in decreased expression of HSD3B4 mRNA
CTD
PMID:26655953
NCBI chr 3:98,406,387...98,417,895
Ensembl chr 3:98,406,387...98,417,830
G
Hspa5
heat shock protein 5
multiple interactions
EXP
GW 4064 inhibits the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of HSPA5 mRNA]
CTD
PMID:28223344
NCBI chr 2:34,662,102...34,666,541
Ensembl chr 2:34,661,982...34,667,559
G
Hyou1
hypoxia up-regulated 1
increases expression
EXP
GW 4064 results in increased expression of HYOU1 protein
CTD
PMID:23178280
NCBI chr 9:44,290,840...44,303,662
Ensembl chr 9:44,290,787...44,303,666
G
Icam1
intercellular adhesion molecule 1
increases expression
ISO
GW 4064 results in increased expression of ICAM1 mRNA
CTD
PMID:16582018
NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113
G
Icam5
intercellular adhesion molecule 5, telencephalin
increases expression
EXP
GW 4064 results in increased expression of ICAM5 mRNA
CTD
PMID:26655953
NCBI chr 9:20,943,372...20,950,331
Ensembl chr 9:20,943,369...20,950,332
G
Icos
inducible T cell co-stimulator
decreases expression
EXP
GW 4064 results in decreased expression of ICOS mRNA
CTD
PMID:26655953
NCBI chr 1:60,999,909...61,039,481
Ensembl chr 1:61,017,086...61,039,479
G
Id4
inhibitor of DNA binding 4
decreases expression
EXP
GW 4064 results in decreased expression of ID4 mRNA
CTD
PMID:26655953
NCBI chr13:48,414,592...48,419,504
Ensembl chr13:48,414,704...48,419,502
G
Ifi27l2b
interferon, alpha-inducible protein 27 like 2B
increases expression
EXP
GW 4064 results in increased expression of IFI27L2B mRNA
CTD
PMID:26655953
NCBI chr12:103,417,157...103,423,482
Ensembl chr12:103,417,157...103,423,482
G
Ifit1
interferon-induced protein with tetratricopeptide repeats 1
decreases expression
EXP
GW 4064 results in decreased expression of IFIT1 mRNA
CTD
PMID:26655953
NCBI chr19:34,618,289...34,627,409
Ensembl chr19:34,618,271...34,627,409
G
Ifit1bl1
interferon induced protein with tetratricpeptide repeats 1B like 1
decreases expression
EXP
GW 4064 results in decreased expression of IFIT1BL1 mRNA
CTD
PMID:26655953
NCBI chr19:34,570,288...34,640,382
Ensembl chr19:34,570,291...34,579,356
G
Igf2bp3
insulin-like growth factor 2 mRNA binding protein 3
increases expression
EXP
GW 4064 results in increased expression of IGF2BP3 mRNA
CTD
PMID:26655953
NCBI chr 6:49,062,152...49,200,225
Ensembl chr 6:49,062,157...49,191,891
G
Igfals
insulin-like growth factor binding protein, acid labile subunit
multiple interactions
EXP
GW 4064 promotes the reaction [NR1H4 protein binds to IGFALS gene]
CTD
PMID:20091679
NCBI chr17:25,096,818...25,100,985
Ensembl chr17:25,084,971...25,100,984
G
Igfbp1
insulin-like growth factor binding protein 1
increases expression
EXP
GW 4064 results in increased expression of IGFBP1 mRNA
CTD
PMID:26655953
NCBI chr11:7,147,787...7,152,546
Ensembl chr11:7,147,782...7,152,546
G
Ighv2-9
immunoglobulin heavy variable 2-9
increases expression
EXP
GW 4064 results in increased expression of IGHV2-9 mRNA
CTD
PMID:26655953
NCBI chr12:113,842,717...113,843,008
Ensembl chr12:113,842,716...113,843,161
G
Ighv6-3
immunoglobulin heavy variable 6-3
decreases expression
EXP
GW 4064 results in decreased expression of IGHV6-3 mRNA
CTD
PMID:26655953
NCBI chr12:114,355,332...114,355,630
Ensembl chr12:114,355,332...114,355,789
G
Iigp1
interferon inducible GTPase 1
decreases expression
EXP
GW 4064 results in decreased expression of IIGP1 mRNA
CTD
PMID:26655953
NCBI chr18:60,506,688...60,525,706
Ensembl chr18:60,509,099...60,525,706
G
Il11
interleukin 11
increases expression
EXP
GW 4064 results in increased expression of IL11 mRNA
CTD
PMID:26655953
NCBI chr 7:4,775,372...4,785,877
Ensembl chr 7:4,775,372...4,785,858
G
Il17b
interleukin 17B
multiple interactions
EXP
GW 4064 promotes the reaction [NR1H4 protein binds to IL17B gene]
CTD
PMID:20091679
NCBI chr18:61,821,006...61,825,609
Ensembl chr18:61,817,958...61,825,609
G
Il1b
interleukin 1 beta
multiple interactions decreases expression increases expression
ISO EXP
GW 4064 inhibits the reaction [TNF protein results in increased expression of IL1B mRNA] GW 4064 results in decreased expression of IL1B mRNA GW 4064 results in increased expression of IL1B mRNA GW 4064 inhibits the reaction [[triptolide co-treated with TNF protein] results in increased expression of IL1B mRNA]
CTD
PMID:21242261 PMID:23371517 PMID:31437187 PMID:36328986
NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
G
Il4ra
interleukin 4 receptor, alpha
increases expression
ISO
GW 4064 results in increased expression of IL4R mRNA
CTD
PMID:31437187
NCBI chr 7:125,151,443...125,178,646
Ensembl chr 7:125,151,292...125,178,646
G
Il6
interleukin 6
multiple interactions increases expression
ISO
[GW 4064 co-treated with Oleic Acid] results in decreased expression of IL6 mRNA GW 4064 results in increased expression of IL6 mRNA
CTD
PMID:30611723 PMID:31437187
NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
G
Inmt
indolethylamine N-methyltransferase
increases expression
EXP
GW 4064 results in increased expression of INMT mRNA
CTD
PMID:26655953
NCBI chr 6:55,147,612...55,151,975
Ensembl chr 6:55,147,611...55,152,028
G
Ip6k3
inositol hexaphosphate kinase 3
decreases expression
EXP
GW 4064 results in decreased expression of IP6K3 mRNA
CTD
PMID:26655953
NCBI chr17:27,362,945...27,386,738
Ensembl chr17:27,362,939...27,386,769
G
Isg15
ISG15 ubiquitin-like modifier
decreases expression
EXP
GW 4064 results in decreased expression of ISG15 mRNA
CTD
PMID:26655953
NCBI chr 4:156,283,881...156,285,275
Ensembl chr 4:156,283,912...156,285,253
G
Itgam
integrin alpha M
decreases expression
EXP
GW 4064 results in decreased expression of ITGAM mRNA
CTD
PMID:23371517
NCBI chr 7:127,661,812...127,717,663
Ensembl chr 7:127,661,812...127,717,663
G
Itgax
integrin alpha X
decreases expression increases expression
EXP
GW 4064 results in decreased expression of ITGAX mRNA GW 4064 results in increased expression of ITGAX mRNA
CTD
PMID:23371517 PMID:26655953
NCBI chr 7:127,728,697...127,749,829
Ensembl chr 7:127,728,719...127,749,829
G
Itih3
inter-alpha trypsin inhibitor, heavy chain 3
increases expression
EXP
GW 4064 results in increased expression of ITIH3 mRNA
CTD
PMID:26655953
NCBI chr14:30,630,529...30,645,748
Ensembl chr14:30,630,529...30,645,717
G
Itpr1
inositol 1,4,5-trisphosphate receptor 1
multiple interactions
EXP
GW 4064 inhibits the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of ITPR1 mRNA]
CTD
PMID:28223344
NCBI chr 6:108,190,044...108,528,077
Ensembl chr 6:108,190,057...108,528,070
G
Jakmip1
janus kinase and microtubule interacting protein 1
decreases expression
EXP
GW 4064 results in decreased expression of JAKMIP1 mRNA
CTD
PMID:26655953
NCBI chr 5:37,182,424...37,307,958
Ensembl chr 5:37,185,679...37,307,951 Ensembl chr 5:37,185,679...37,307,951
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Jph2
junctophilin 2
increases expression
EXP
GW 4064 results in increased expression of JPH2 mRNA
CTD
PMID:26655953
NCBI chr 2:163,178,162...163,239,969
Ensembl chr 2:163,178,162...163,239,913
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Kbtbd11
kelch repeat and BTB (POZ) domain containing 11
decreases expression
EXP
GW 4064 results in decreased expression of KBTBD11 mRNA
CTD
PMID:26655953
NCBI chr 8:15,059,408...15,083,333
Ensembl chr 8:15,061,025...15,083,333
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Kbtbd13
kelch repeat and BTB (POZ) domain containing 13
increases expression
EXP
GW 4064 results in increased expression of KBTBD13 mRNA
CTD
PMID:26655953
NCBI chr 9:65,295,965...65,299,000
Ensembl chr 9:65,295,966...65,298,934
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Kcne4
potassium voltage-gated channel, Isk-related subfamily, gene 4
increases expression
EXP
GW 4064 results in increased expression of KCNE4 mRNA
CTD
PMID:26655953
NCBI chr 1:78,794,628...78,797,749
Ensembl chr 1:78,794,475...78,797,745
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Kcne5
potassium voltage-gated channel subfamily E regulatory subunit 5
decreases expression
EXP
GW 4064 results in decreased expression of KCNE5 mRNA
CTD
PMID:26655953
NCBI chr X:141,087,749...141,089,194
Ensembl chr X:141,087,748...141,089,290
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Kcnh8
potassium voltage-gated channel, subfamily H (eag-related), member 8
decreases expression
EXP
GW 4064 results in decreased expression of KCNH8 mRNA
CTD
PMID:26655953
NCBI chr17:52,909,535...53,286,892
Ensembl chr17:52,909,737...53,286,222
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Kcnip3
Kv channel interacting protein 3, calsenilin
decreases expression
EXP
GW 4064 results in decreased expression of KCNIP3 mRNA
CTD
PMID:26655953
NCBI chr 2:127,298,418...127,364,014
Ensembl chr 2:127,298,418...127,364,014
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Kcnip4
Kv channel interacting protein 4
increases expression
EXP
GW 4064 results in increased expression of KCNIP4 mRNA
CTD
PMID:26655953
NCBI chr 5:48,546,845...49,682,464
Ensembl chr 5:48,546,844...49,682,249
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Kcnj4
potassium inwardly-rectifying channel, subfamily J, member 4
decreases expression
EXP
GW 4064 results in decreased expression of KCNJ4 mRNA
CTD
PMID:26655953
NCBI chr15:79,364,427...79,396,712
Ensembl chr15:79,367,915...79,389,442
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Kif5a
kinesin family member 5A
increases expression
EXP
GW 4064 results in increased expression of KIF5A mRNA
CTD
PMID:26655953
NCBI chr10:127,061,564...127,102,217
Ensembl chr10:127,061,565...127,099,217
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Klhl14
kelch-like 14
decreases expression
EXP
GW 4064 results in decreased expression of KLHL14 mRNA
CTD
PMID:26655953
NCBI chr18:21,683,436...21,805,986
Ensembl chr18:21,683,434...21,787,775
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Klk1b5
kallikrein 1-related peptidase b5
decreases expression
EXP
GW 4064 results in decreased expression of KLK1B5 mRNA
CTD
PMID:26655953
NCBI chr 7:43,865,898...43,870,127
Ensembl chr 7:43,865,369...43,870,127
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Kmo
kynurenine 3-monooxygenase
increases expression
EXP
GW 4064 results in increased expression of KMO mRNA
CTD
PMID:26655953
NCBI chr 1:175,459,759...175,488,419
Ensembl chr 1:175,447,947...175,489,682
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Kng1
kininogen 1
multiple interactions increases expression
ISO
alpha-Linolenic Acid inhibits the reaction [GW 4064 results in increased expression of KNG1 mRNA]; Arachidonic Acid inhibits the reaction [GW 4064 results in increased expression of KNG1 mRNA]; Docosahexaenoic Acids inhibits the reaction [GW 4064 results in increased expression of KNG1 mRNA]
CTD
PMID:15307955
NCBI chr16:22,876,970...22,900,828
Ensembl chr16:22,876,615...22,900,828
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Krt17
keratin 17
increases expression
EXP
GW 4064 results in increased expression of KRT17 mRNA
CTD
PMID:26655953
NCBI chr11:100,147,041...100,151,855
Ensembl chr11:100,147,043...100,151,855
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Kynu
kynureninase
increases expression
EXP
GW 4064 results in increased expression of KYNU mRNA
CTD
PMID:26655953
NCBI chr 2:43,445,270...43,572,734
Ensembl chr 2:43,445,341...43,572,734
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Lama4
laminin, alpha 4
decreases expression
EXP
GW 4064 results in decreased expression of LAMA4 mRNA
CTD
PMID:26655953
NCBI chr10:38,841,511...38,986,184
Ensembl chr10:38,841,511...38,986,184
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Lce1f
late cornified envelope 1F
increases expression
EXP
GW 4064 results in increased expression of LCE1F mRNA
CTD
PMID:26655953
NCBI chr 3:92,626,003...92,627,657
Ensembl chr 3:92,625,992...92,627,657
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Ldha
lactate dehydrogenase A
multiple interactions
EXP
GW 4064 promotes the reaction [NR1H4 protein binds to LDHA gene]
CTD
PMID:20091679
NCBI chr 7:46,491,698...46,505,051
Ensembl chr 7:46,490,899...46,505,051
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Lgi2
leucine-rich repeat LGI family, member 2
decreases expression
EXP
GW 4064 results in decreased expression of LGI2 mRNA
CTD
PMID:26655953
NCBI chr 5:52,690,859...52,723,689
Ensembl chr 5:52,690,859...52,723,804
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Lgi3
leucine-rich repeat LGI family, member 3
decreases expression
EXP
GW 4064 results in decreased expression of LGI3 mRNA
CTD
PMID:26655953
NCBI chr14:70,765,982...70,775,764
Ensembl chr14:70,768,125...70,775,764
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Lhx9
LIM homeobox protein 9
decreases expression
EXP
GW 4064 results in decreased expression of LHX9 mRNA
CTD
PMID:26655953
NCBI chr 1:138,752,924...138,776,577
Ensembl chr 1:138,752,924...138,776,315
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Lipc
lipase, hepatic
decreases expression multiple interactions
ISO
GW 4064 results in decreased expression of LIPC mRNA [GW 4064 co-treated with Oleic Acid] results in decreased expression of LIPC mRNA
CTD
PMID:30611723
NCBI chr 9:70,705,410...70,859,503
Ensembl chr 9:70,705,410...70,859,508
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Lpar3
lysophosphatidic acid receptor 3
increases expression
EXP
GW 4064 results in increased expression of LPAR3 mRNA
CTD
PMID:26655953
NCBI chr 3:145,926,716...145,991,969
Ensembl chr 3:145,926,718...145,991,941
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Lpin1
lipin 1
decreases expression multiple interactions
ISO
GW 4064 results in decreased expression of LPIN1 mRNA [GW 4064 co-treated with Oleic Acid] results in decreased expression of LPIN1 mRNA
CTD
PMID:30611723
NCBI chr12:16,585,670...16,697,020
Ensembl chr12:16,585,670...16,696,967
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Lpin2
lipin 2
multiple interactions decreases expression
ISO
[GW 4064 co-treated with Oleic Acid] results in decreased expression of LPIN2 mRNA GW 4064 results in decreased expression of LPIN2 mRNA
CTD
PMID:30611723
NCBI chr17:71,490,527...71,556,813
Ensembl chr17:71,489,555...71,556,812
G
Lpin3
lipin 3
multiple interactions decreases expression
ISO
[GW 4064 co-treated with Oleic Acid] results in decreased expression of LPIN3 mRNA GW 4064 results in decreased expression of LPIN3 mRNA
CTD
PMID:30611723
NCBI chr 2:160,722,590...160,747,920
Ensembl chr 2:160,722,590...160,747,922
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Lrrc25
leucine rich repeat containing 25
increases expression
EXP
GW 4064 results in increased expression of LRRC25 mRNA
CTD
PMID:26655953
NCBI chr 8:71,068,810...71,073,501
Ensembl chr 8:71,068,805...71,074,133
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Lrrc43
leucine rich repeat containing 43
increases expression
EXP
GW 4064 results in increased expression of LRRC43 mRNA
CTD
PMID:26655953
NCBI chr 5:123,627,349...123,646,268
Ensembl chr 5:123,627,368...123,646,268
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Lrrn3
leucine rich repeat protein 3, neuronal
decreases expression
EXP
GW 4064 results in decreased expression of LRRN3 mRNA
CTD
PMID:26655953
NCBI chr12:41,501,667...41,536,056
Ensembl chr12:41,501,667...41,536,430
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Ltbp1
latent transforming growth factor beta binding protein 1
increases expression
EXP
GW 4064 results in increased expression of LTBP1 mRNA
CTD
PMID:26655953
NCBI chr17:75,312,475...75,699,507
Ensembl chr17:75,312,563...75,699,507
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Mad2l1
MAD2 mitotic arrest deficient-like 1
increases expression
ISO
GW 4064 results in increased expression of MAD2L1 mRNA
CTD
PMID:31437187
NCBI chr 6:66,512,205...66,518,091
Ensembl chr 6:66,512,374...66,524,204
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Mapk8
mitogen-activated protein kinase 8
multiple interactions increases expression
ISO EXP
GW 4064 inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein]; NR1H4 promotes the reaction [GW 4064 inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein]]; SOD3 promotes the reaction [GW 4064 inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein]] GW 4064 inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein]; GW 4064 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK8 protein] GW 4064 results in increased expression of MAPK8 mRNA
CTD
PMID:25496033 PMID:26655953
NCBI chr14:33,099,855...33,169,213
Ensembl chr14:33,099,855...33,169,115
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Mapk9
mitogen-activated protein kinase 9
multiple interactions
ISO EXP
GW 4064 inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK9 protein]; NR1H4 promotes the reaction [GW 4064 inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK9 protein]]; SOD3 promotes the reaction [GW 4064 inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK9 protein]] GW 4064 inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK9 protein]; GW 4064 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK9 protein]
CTD
PMID:25496033
NCBI chr11:49,737,558...49,777,248
Ensembl chr11:49,737,578...49,777,248
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Mcat
malonyl CoA:ACP acyltransferase (mitochondrial)
multiple interactions
ISO
[GW 4064 co-treated with Oleic Acid] results in decreased expression of MCAT mRNA
CTD
PMID:30611723
NCBI chr15:83,430,998...83,439,936
Ensembl chr15:83,430,998...83,447,988
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Mcm2
minichromosome maintenance complex component 2
increases expression
ISO
GW 4064 results in increased expression of MCM2 mRNA
CTD
PMID:31437187
NCBI chr 6:88,860,456...88,875,762
Ensembl chr 6:88,860,456...88,875,762
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Mcm4
minichromosome maintenance complex component 4
increases expression
ISO
GW 4064 results in increased expression of MCM4 mRNA
CTD
PMID:31437187
NCBI chr16:15,441,761...15,455,264
Ensembl chr16:15,441,761...15,455,264
G
Mcm5
minichromosome maintenance complex component 5
increases expression
ISO
GW 4064 results in increased expression of MCM5 mRNA
CTD
PMID:31437187
NCBI chr 8:75,836,096...75,855,067
Ensembl chr 8:75,836,197...75,855,067
G
Mcm6
minichromosome maintenance complex component 6
increases expression
ISO
GW 4064 results in increased expression of MCM6 mRNA
CTD
PMID:31437187
NCBI chr 1:128,259,312...128,287,442
Ensembl chr 1:128,259,327...128,287,401
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Mcm7
minichromosome maintenance complex component 7
increases expression
ISO
GW 4064 results in increased expression of MCM7 mRNA
CTD
PMID:31437187
NCBI chr 5:138,162,845...138,170,675
Ensembl chr 5:138,162,845...138,170,684
G
Me3
malic enzyme 3, NADP(+)-dependent, mitochondrial
decreases expression
EXP
GW 4064 results in decreased expression of ME3 mRNA
CTD
PMID:26655953
NCBI chr 7:89,281,492...89,503,423
Ensembl chr 7:89,281,600...89,503,567
G
Mecr
mitochondrial trans-2-enoyl-CoA reductase
multiple interactions
ISO
[GW 4064 co-treated with Oleic Acid] results in decreased expression of MECR mRNA
CTD
PMID:30611723
NCBI chr 4:131,570,755...131,595,097
Ensembl chr 4:131,570,781...131,595,097
G
Megf11
multiple EGF-like-domains 11
decreases expression
EXP
GW 4064 results in decreased expression of MEGF11 mRNA
CTD
PMID:26655953
NCBI chr 9:64,291,556...64,618,584
Ensembl chr 9:64,292,908...64,616,487
G
Megf6
multiple EGF-like-domains 6
increases expression
EXP
GW 4064 results in increased expression of MEGF6 mRNA
CTD
PMID:26655953
NCBI chr 4:154,255,156...154,360,178
Ensembl chr 4:154,255,187...154,360,170
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Meox1
mesenchyme homeobox 1
increases expression
EXP
GW 4064 results in increased expression of MEOX1 mRNA
CTD
PMID:26655953
NCBI chr11:101,768,336...101,785,309
Ensembl chr11:101,768,336...101,785,200
G
Mfn2
mitofusin 2
multiple interactions
EXP
GW 4064 inhibits the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of MFN2 mRNA]
CTD
PMID:28223344
NCBI chr 4:147,958,043...147,989,527
Ensembl chr 4:147,958,056...147,989,161
G
Mfsd2a
MFSD2 lysolipid transporter A, lysophospholipid
decreases expression
EXP
GW 4064 results in decreased expression of MFSD2A mRNA
CTD
PMID:26655953
NCBI chr 4:122,840,643...122,855,844
Ensembl chr 4:122,840,643...122,854,981
G
Mgarp
mitochondria localized glutamic acid rich protein
decreases expression
EXP
GW 4064 results in decreased expression of MGARP mRNA
CTD
PMID:26655953
NCBI chr 3:51,295,833...51,303,968
Ensembl chr 3:51,295,833...51,304,159
G
Mindy4
MINDY lysine 48 deubiquitinase 4
increases expression
EXP
GW 4064 results in increased expression of MINDY4 mRNA
CTD
PMID:26655953
NCBI chr 6:55,180,337...55,297,208
Ensembl chr 6:55,180,368...55,297,207
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Miox
myo-inositol oxygenase
increases expression
EXP
GW 4064 results in increased expression of MIOX mRNA
CTD
PMID:26655953
NCBI chr15:89,218,676...89,221,210
Ensembl chr15:89,218,601...89,221,218
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Mir126a
microRNA 126a
multiple interactions
EXP
GW 4064 promotes the reaction [NR1H4 protein binds to MIR126 gene]
CTD
PMID:20091679
NCBI chr 2:26,481,369...26,481,441
Ensembl chr 2:26,481,369...26,481,441
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Mir499
microRNA 499
multiple interactions
EXP
GW 4064 promotes the reaction [NR1H4 protein binds to MIR499 gene]
CTD
PMID:20091679
NCBI chr 2:155,464,800...155,464,878
Ensembl chr 2:155,464,800...155,464,878
G
Mlxipl
MLX interacting protein-like
decreases expression multiple interactions
ISO
GW 4064 results in decreased expression of MLXIPL mRNA [GW 4064 co-treated with Oleic Acid] results in decreased expression of MLXIPL mRNA
CTD
PMID:30611723
NCBI chr 5:135,118,744...135,168,622
Ensembl chr 5:135,118,744...135,167,236
G
Mmp7
matrix metallopeptidase 7
decreases expression
EXP
GW 4064 results in decreased expression of MMP7 mRNA
CTD
PMID:26655953
NCBI chr 9:7,692,095...7,699,587
Ensembl chr 9:7,692,091...7,699,587
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Mogat2
monoacylglycerol O-acyltransferase 2
increases expression
EXP
GW 4064 results in increased expression of MOGAT2 mRNA
CTD
PMID:26655953
NCBI chr 7:98,868,291...98,887,818
Ensembl chr 7:98,868,291...98,887,826
G
Ms4a6d
membrane-spanning 4-domains, subfamily A, member 6D
increases expression
EXP
GW 4064 results in increased expression of MS4A6D mRNA
CTD
PMID:26655953
NCBI chr19:11,563,970...11,582,150
Ensembl chr19:11,563,968...11,582,213
G
Mtfmt
mitochondrial methionyl-tRNA formyltransferase
decreases expression multiple interactions
EXP
GW 4064 results in decreased expression of MTFMT mRNA NR0B2 protein promotes the reaction [GW 4064 results in decreased expression of MTFMT mRNA]
CTD
PMID:29416063
NCBI chr 9:65,343,064...65,360,336
Ensembl chr 9:65,343,064...65,360,336
G
Mthfr
methylenetetrahydrofolate reductase
decreases expression multiple interactions
EXP
GW 4064 results in decreased expression of MTHFR mRNA NR0B2 protein promotes the reaction [GW 4064 results in decreased expression of MTHFR mRNA]
CTD
PMID:29416063
NCBI chr 4:148,123,534...148,144,019
Ensembl chr 4:148,123,534...148,144,008
G
Mttp
microsomal triglyceride transfer protein
multiple interactions decreases expression
ISO
[GW 4064 co-treated with Oleic Acid] results in decreased expression of MTTP mRNA GW 4064 results in decreased expression of MTTP mRNA
CTD
PMID:30611723
NCBI chr 3:137,795,616...137,849,179
Ensembl chr 3:137,795,615...137,850,729
G
Muc13
mucin 13, epithelial transmembrane
increases expression
EXP
GW 4064 results in increased expression of MUC13 mRNA
CTD
PMID:26655953
NCBI chr16:33,614,407...33,640,299
Ensembl chr16:33,614,407...33,640,304
G
Mx1
MX dynamin-like GTPase 1
decreases expression
EXP
GW 4064 results in decreased expression of MX1 mRNA
CTD
PMID:26655953
NCBI chr16:97,248,235...97,264,106
Ensembl chr16:97,248,235...97,264,107
G
Mybl1
myeloblastosis oncogene-like 1
increases expression
EXP
GW 4064 results in increased expression of MYBL1 mRNA
CTD
PMID:26655953
NCBI chr 1:9,737,632...9,770,664
Ensembl chr 1:9,737,640...9,770,434
G
Mybpc2
myosin binding protein C, fast-type
decreases expression
EXP
GW 4064 results in decreased expression of MYBPC2 mRNA
CTD
PMID:26655953
NCBI chr 7:44,151,123...44,174,093
Ensembl chr 7:44,151,123...44,174,080
G
Myc
myelocytomatosis oncogene
increases expression
ISO
GW 4064 results in increased expression of MYC mRNA
CTD
PMID:31437187
NCBI chr15:61,857,190...61,862,210
Ensembl chr15:61,857,240...61,862,223
G
Myh3
myosin, heavy polypeptide 3, skeletal muscle, embryonic
decreases expression
EXP
GW 4064 results in decreased expression of MYH3 mRNA
CTD
PMID:26655953
NCBI chr11:66,969,101...66,993,117
Ensembl chr11:66,969,126...66,993,112
G
Mylip
myosin regulatory light chain interacting protein
decreases expression
ISO
GW 4064 results in decreased expression of MYLIP mRNA
CTD
PMID:31437187
NCBI chr13:45,543,197...45,565,498
Ensembl chr13:45,543,218...45,565,498
G
Mylpf
myosin light chain, phosphorylatable, fast skeletal muscle
decreases expression
EXP
GW 4064 results in decreased expression of MYLPF mRNA
CTD
PMID:26655953
NCBI chr 7:126,808,071...126,813,459
Ensembl chr 7:126,808,062...126,813,470
G
Myo18b
myosin XVIIIb
increases expression
EXP
GW 4064 results in increased expression of MYO18B mRNA
CTD
PMID:26655953
NCBI chr 5:112,836,742...113,044,311
Ensembl chr 5:112,836,742...113,044,228
G
Myo1f
myosin IF
increases expression
EXP
GW 4064 results in increased expression of MYO1F mRNA
CTD
PMID:26655953
NCBI chr17:33,774,681...33,826,738
Ensembl chr17:33,774,681...33,826,738
G
Myo1h
myosin 1H
decreases expression
EXP
GW 4064 results in decreased expression of MYO1H mRNA
CTD
PMID:26655953
NCBI chr 5:114,427,314...114,502,637
Ensembl chr 5:114,427,227...114,503,418
G
Naip1
NLR family, apoptosis inhibitory protein 1
increases expression
EXP
GW 4064 results in increased expression of NAIP1 mRNA
CTD
PMID:26655953
NCBI chr13:100,544,272...100,589,372
Ensembl chr13:100,544,272...100,589,377
G
Nanog
Nanog homeobox
multiple interactions decreases expression
EXP
bisphenol A inhibits the reaction [GW 4064 results in decreased expression of NANOG mRNA]; Stigmasterol inhibits the reaction [GW 4064 results in decreased expression of NANOG mRNA]
CTD
PMID:30245210
NCBI chr 6:122,684,448...122,691,592
Ensembl chr 6:122,684,448...122,691,592
G
Nat2
N-acetyltransferase 2 (arylamine N-acetyltransferase)
multiple interactions
EXP
GW 4064 promotes the reaction [NR1H4 protein binds to NAT2 gene]
CTD
PMID:20091679
NCBI chr 8:67,947,527...67,955,296
Ensembl chr 8:67,947,510...67,955,236
G
Nat8b-ps
N-acetyltransferase 8B, pseudogene
increases expression
EXP
GW 4064 results in increased expression of NAT8B mRNA
CTD
PMID:26655953
NCBI chr 6:85,909,539...85,910,364
Ensembl chr 6:85,909,663...85,910,361
G
Ncoa1
nuclear receptor coactivator 1
multiple interactions
ISO
GW 4064 promotes the reaction [NCOA1 protein binds to NR1H4 protein]; GW 4064 promotes the reaction [NR1H4 protein binds to NCOA1 protein]
CTD
PMID:14684751 PMID:21256005
NCBI chr12:4,297,362...4,569,452
Ensembl chr12:4,297,362...4,527,182
G
Ncoa7
nuclear receptor coactivator 7
increases expression
EXP
GW 4064 results in increased expression of NCOA7 mRNA
CTD
PMID:26655953
NCBI chr10:30,521,578...30,683,401
Ensembl chr10:30,504,995...30,679,322
G
Ndufa4l2
Ndufa4, mitochondrial complex associated like 2
decreases expression
EXP
GW 4064 results in decreased expression of NDUFA4L2 mRNA
CTD
PMID:26655953
NCBI chr10:127,345,143...127,353,023
Ensembl chr10:127,350,836...127,353,023
G
Necab2
N-terminal EF-hand calcium binding protein 2
increases expression
EXP
GW 4064 results in increased expression of NECAB2 mRNA
CTD
PMID:26655953
NCBI chr 8:120,173,431...120,199,379
Ensembl chr 8:120,173,458...120,199,379
G
Necab3
N-terminal EF-hand calcium binding protein 3
increases expression
EXP
GW 4064 results in increased expression of NECAB3 mRNA
CTD
PMID:26655953
NCBI chr 2:154,386,311...154,401,326
Ensembl chr 2:154,386,319...154,400,810
G
Nherf4
NHERF family PDZ scaffold protein 4
increases expression
EXP
GW 4064 results in increased expression of NHERF4 mRNA
CTD
PMID:26655953
NCBI chr 9:44,158,609...44,162,761
Ensembl chr 9:44,158,604...44,162,768
G
Nhsl2
NHS like 2
increases expression
EXP
GW 4064 results in increased expression of NHSL2 mRNA
CTD
PMID:26655953
NCBI chr X:100,892,942...101,135,661
Ensembl chr X:100,892,991...101,135,661
G
Nlrp3
NLR family, pyrin domain containing 3
multiple interactions
EXP
GW 4064 inhibits the reaction [[triptolide co-treated with TNF protein] results in increased expression of NLRP3 protein]
CTD
PMID:36328986
NCBI chr11:59,432,395...59,457,781
Ensembl chr11:59,432,394...59,457,782
G
Nol3
nucleolar protein 3 (apoptosis repressor with CARD domain)
decreases expression
EXP
GW 4064 results in decreased expression of NOL3 mRNA
CTD
PMID:26655953
NCBI chr 8:106,002,777...106,008,571
Ensembl chr 8:106,002,772...106,008,571
G
Nos1
nitric oxide synthase 1, neuronal
increases expression
EXP
GW 4064 results in increased expression of NOS1 mRNA
CTD
PMID:26655953
NCBI chr 5:118,004,904...118,096,905
Ensembl chr 5:117,919,097...118,096,905
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Npm3
nucleoplasmin 3
increases expression
EXP
GW 4064 results in increased expression of NPM3 mRNA
CTD
PMID:26655953
NCBI chr19:45,736,173...45,738,004
Ensembl chr19:45,736,173...45,738,030
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Npy6r
neuropeptide Y receptor Y6
decreases expression
EXP
GW 4064 results in decreased expression of NPY6R mRNA
CTD
PMID:26655953
NCBI chr18:44,403,175...44,410,767
Ensembl chr18:44,403,194...44,410,767
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Nqo1
NAD(P)H dehydrogenase, quinone 1
increases expression
EXP
GW 4064 results in increased expression of NQO1 mRNA
CTD
PMID:26655953
NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838
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Nr0b1
nuclear receptor subfamily 0, group B, member 1
multiple interactions decreases expression
EXP
GW 4064 promotes the reaction [Stigmasterol results in increased expression of NR0B1 mRNA]; NR1H4 gene mutant form inhibits the reaction [GW 4064 results in decreased expression of NR0B1 mRNA]; Stigmasterol inhibits the reaction [GW 4064 results in decreased expression of NR0B1 mRNA]
CTD
PMID:30245210
NCBI chr X:85,235,381...85,239,553
Ensembl chr X:85,235,370...85,239,553
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Nr0b2
nuclear receptor subfamily 0, group B, member 2
multiple interactions increases expression
ISO EXP
[GW 4064 binds to and results in increased activity of NR1H4 protein] which results in increased expression of NR0B2 mRNA; [GW 4064 co-treated with Oleic Acid] results in increased expression of NR0B2 mRNA; epigallocatechin gallate inhibits the reaction [GW 4064 results in increased expression of NR0B2 mRNA] [GW 4064 binds to and results in increased activity of NR1H4 protein] which results in increased expression of NR0B2 mRNA; ATP7B protein affects the reaction [GW 4064 results in increased expression of NR0B2 mRNA]; GW 4064 inhibits the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of NR0B2 mRNA]; GW 4064 inhibits the reaction [[triptolide co-treated with TNF protein] results in decreased expression of NR0B2 protein]; GW 4064 inhibits the reaction [ATP7B gene mutant form results in decreased expression of NR0B2 mRNA]; GW 4064 inhibits the reaction [Oleanolic Acid results in decreased expression of NR0B2 mRNA]; GW 4064 promotes the reaction [NR1H4 protein binds to NR0B2 gene]; NR0B2 protein promotes the reaction [GW 4064 results in decreased expression of AHCYL2 mRNA]; NR0B2 protein promotes the reaction [GW 4064 results in decreased expression of GNMT mRNA]; NR0B2 protein promotes the reaction [GW 4064 results in decreased expression of MTFMT mRNA]; NR0B2 protein promotes the reaction [GW 4064 results in decreased expression of MTHFR mRNA]; NR0B2 protein promotes the reaction [GW 4064 results in decreased expression of PEMT mRNA]; NR1H4 gene mutant form inhibits the reaction [GW 4064 results in increased expression of NR0B2 mRNA]; NR1H4 mutant form inhibits the reaction [GW 4064 results in increased expression of NR0B2 mRNA]; Stigmasterol promotes the reaction [GW 4064 results in increased expression of NR0B2 mRNA]
CTD
PMID:14623915 PMID:15644430 PMID:15980055 PMID:16269825 PMID:19072826 PMID:20091679 PMID:21480330 PMID:22178739 PMID:22414727 PMID:22540009 PMID:22918042 PMID:23178280 PMID:25550158 PMID:26241054 PMID:27609522 PMID:28223344 PMID:29416063 PMID:30245210 PMID:30611723 PMID:31437187 PMID:36328986 PMID:37028458 More...
NCBI chr 4:133,280,687...133,283,997
Ensembl chr 4:133,280,687...133,283,847
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Nr1h4
nuclear receptor subfamily 1, group H, member 4
multiple interactions affects binding increases activity increases expression decreases response to substance decreases expression increases phosphorylation
ISO EXP
[[GW 4064 binds to and results in increased activity of NR1H4 protein] which binds to ABCB4 promoter] which results in increased expression of ABCB4 mRNA; [[GW 4064 results in increased activity of NR1H4 protein] which binds to FGF19 promoter] which results in increased expression of FGF19 mRNA; [GW 4064 binds to and results in increased activity of NR1H4 protein] which results in increased expression of NR0B2 mRNA; [GW 4064 binds to and results in increased activity of NR1H4 protein] which results in increased expression of SCARB1 mRNA; [GW 4064 co-treated with Oleic Acid] results in decreased expression of NR1H4 mRNA; [GW 4064 results in increased activity of NR1H4 protein] which binds to FGF19 promoter; [GW 4064 results in increased activity of NR1H4 protein] which results in increased expression of UGT1A3 mRNA; epigallocatechin gallate inhibits the reaction [GW 4064 results in increased activity of NR1H4 protein]; epigallocatechin gallate inhibits the reaction [GW 4064 results in increased expression of NR1H4 mRNA]; GW 4064 binds to and results in increased activity of NR1H4 protein; GW 4064 inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein]; GW 4064 inhibits the reaction [TNF protein results in increased expression of NR1H4 mRNA]; GW 4064 promotes the reaction [NCOA1 protein binds to NR1H4 protein]; GW 4064 promotes the reaction [NR1H4 protein binds to NCOA1 protein]; GW 4064 promotes the reaction [NR1H4 protein binds to SOD3 promoter]; GW 4064 promotes the reaction [NR1H4 protein results in increased export of Taurocholic Acid]; NR1H4 promotes the reaction [GW 4064 inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein]]; NR1H4 promotes the reaction [GW 4064 inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK9 protein]] GW 4064 binds to NR1H4 protein [GW 4064 binds to and results in increased activity of NR1H4 protein] which results in decreased expression of CYP7A1 mRNA; [GW 4064 binds to and results in increased activity of NR1H4 protein] which results in decreased expression of SLC10A1 mRNA; [GW 4064 binds to and results in increased activity of NR1H4 protein] which results in increased expression of ABCB11 mRNA; [GW 4064 binds to and results in increased activity of NR1H4 protein] which results in increased expression of NR0B2 mRNA; [GW 4064 binds to and results in increased activity of NR1H4 protein] which results in increased expression of SCARB1 mRNA; [GW 4064 binds to and results in increased activity of NR1H4 protein] which results in increased expression of SLC51B mRNA; [GW 4064 results in increased activity of NR1H4 protein] which results in decreased expression of CYP7A1 mRNA; FGFR4 protein affects the reaction [[GW 4064 results in increased activity of NR1H4 protein] which results in decreased expression of CYP7A1 mRNA]; GW 4064 binds to and results in increased activity of NR1H4 protein; GW 4064 inhibits the reaction [Oleanolic Acid results in decreased expression of NR1H4 mRNA]; GW 4064 inhibits the reaction [Oleanolic Acid results in decreased expression of NR1H4 protein]; GW 4064 promotes the reaction [NR1H4 protein binds to ACTG1 gene]; GW 4064 promotes the reaction [NR1H4 protein binds to APOE gene]; GW 4064 promotes the reaction [NR1H4 protein binds to BCCIP gene]; GW 4064 promotes the reaction [NR1H4 protein binds to CAPRIN1 gene]; GW 4064 promotes the reaction [NR1H4 protein binds to CDK5RAP2 gene]; GW 4064 promotes the reaction [NR1H4 protein binds to CEBPB gene]; GW 4064 promotes the reaction [NR1H4 protein binds to CKS2 gene]; GW 4064 promotes the reaction [NR1H4 protein binds to CNNM3 gene]; GW 4064 promotes the reaction [NR1H4 protein binds to ELL2 gene]; GW 4064 promotes the reaction [NR1H4 protein binds to FCNA gene]; GW 4064 promotes the reaction [NR1H4 protein binds to FGA gene]; GW 4064 promotes the reaction [NR1H4 protein binds to FGF15 gene]; GW 4064 promotes the reaction [NR1H4 protein binds to GATD1 gene]; GW 4064 promotes the reaction [NR1H4 protein binds to GPBP1 gene]; GW 4064 promotes the reaction [NR1H4 protein binds to GTF2A2 gene]; GW 4064 promotes the reaction [NR1H4 protein binds to HMGA1 gene]; GW 4064 promotes the reaction [NR1H4 protein binds to IGFALS gene]; GW 4064 promotes the reaction [NR1H4 protein binds to IL17B gene]; GW 4064 promotes the reaction [NR1H4 protein binds to LDHA gene]; GW 4064 promotes the reaction [NR1H4 protein binds to MIR126 gene]; GW 4064 promotes the reaction [NR1H4 protein binds to MIR499 gene]; GW 4064 promotes the reaction [NR1H4 protein binds to NAT2 gene]; GW 4064 promotes the reaction [NR1H4 protein binds to NR0B2 gene]; GW 4064 promotes the reaction [NR1H4 protein binds to PCX gene]; GW 4064 promotes the reaction [NR1H4 protein binds to PDGFRB gene]; GW 4064 promotes the reaction [NR1H4 protein binds to PLAT gene]; GW 4064 promotes the reaction [NR1H4 protein binds to RARRES2 gene]; GW 4064 promotes the reaction [NR1H4 protein binds to SCARB1 intron]; GW 4064 promotes the reaction [NR1H4 protein binds to SLC10A1 gene]; GW 4064 promotes the reaction [NR1H4 protein binds to SLC22A21 gene]; GW 4064 promotes the reaction [NR1H4 protein binds to SLC25A3 gene]; GW 4064 promotes the reaction [NR1H4 protein binds to SLC51A gene]; GW 4064 promotes the reaction [NR1H4 protein binds to SLC51B gene]; GW 4064 promotes the reaction [NR1H4 protein binds to SLC9A8 gene]; GW 4064 promotes the reaction [NR1H4 protein binds to STAT2 gene]; GW 4064 promotes the reaction [NR1H4 protein binds to SUMO3 gene]; GW 4064 promotes the reaction [NR1H4 protein binds to TFAP2E gene]; GW 4064 promotes the reaction [NR1H4 protein binds to TLR3 gene]; GW 4064 promotes the reaction [NR1H4 protein binds to TRPM7 gene]; GW 4064 promotes the reaction [NR1H4 protein binds to VKORC1 gene]; NR1H4 gene mutant form inhibits the reaction [GW 4064 results in decreased expression of FSHR mRNA]; NR1H4 gene mutant form inhibits the reaction [GW 4064 results in decreased expression of NR0B1 mRNA]; NR1H4 gene mutant form inhibits the reaction [GW 4064 results in decreased expression of PDK4 mRNA]; NR1H4 gene mutant form inhibits the reaction [GW 4064 results in decreased expression of STRA8 mRNA]; NR1H4 gene mutant form inhibits the reaction [GW 4064 results in decreased expression of ZBTB16 mRNA]; NR1H4 gene mutant form inhibits the reaction [GW 4064 results in increased expression of ABCB11 mRNA]; NR1H4 gene mutant form inhibits the reaction [GW 4064 results in increased expression of ABCG5 mRNA]; NR1H4 gene mutant form inhibits the reaction [GW 4064 results in increased expression of APOA1 mRNA]; NR1H4 gene mutant form inhibits the reaction [GW 4064 results in increased expression of FABP6 mRNA]; NR1H4 gene mutant form inhibits the reaction [GW 4064 results in increased expression of FGF15 mRNA]; NR1H4 gene mutant form inhibits the reaction [GW 4064 results in increased expression of NR0B2 mRNA]; NR1H4 gene mutant form inhibits the reaction [GW 4064 results in increased expression of SOD3 mRNA]; NR1H4 mutant form inhibits the reaction [GW 4064 results in increased expression of HHEX mRNA]; NR1H4 mutant form inhibits the reaction [GW 4064 results in increased expression of NR0B2 mRNA]; NR1H4 protein promotes the reaction [GW 4064 results in increased expression of ABCB11 protein]; systhane inhibits the reaction [GW 4064 results in increased activity of NR1H4 protein] NR1H4 gene mutant form results in decreased susceptibility to GW 4064 GW 4064 results in decreased expression of NR1H4 mRNA GW 4064 results in increased phosphorylation of NR1H4 protein gw4064 increases expression of nr1h4 mRNA and protein in rat embryonic liver cells GW4064 increases expression of Nr1H4 mRNA in rat hepatic stellate cells GW 4064 increases expression of Nr1h4 mRNA in primary hepatocytes GW 4064 inhibits the reaction [17alpha-ethynylestradiol decreases expression of Nr1h4 mRNA in primary hepatocytes]
CTD RGD
PMID:12519787 PMID:12525500 PMID:14527955 PMID:14623915 PMID:14684751 PMID:15980055 PMID:16582018 PMID:16946559 PMID:17567710 PMID:19072826 PMID:19445040 PMID:20091679 PMID:20189675 PMID:21242261 PMID:21256005 PMID:21291553 PMID:21480330 PMID:22178739 PMID:22414727 PMID:22467244 PMID:22540009 PMID:22561792 PMID:22918042 PMID:22961653 PMID:24812009 PMID:25257666 PMID:25496033 PMID:25689681 PMID:29968724 PMID:30245210 PMID:30611723 PMID:36511616 PMID:36542898 PMID:37028458 PMID:29235094 PMID:15980055 PMID:27090119 PMID:27090119 More...
RGD:15042872 , RGD:1625201 , RGD:15090804 , RGD:15090804
NCBI chr10:89,290,096...89,369,484
Ensembl chr10:89,290,096...89,369,447
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Nr1i2
nuclear receptor subfamily 1, group I, member 2
increases expression
EXP
GW 4064 results in increased expression of NR1I2 mRNA
CTD
PMID:26655953
NCBI chr16:38,068,711...38,115,211
Ensembl chr16:38,068,685...38,115,186
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Nr1i3
nuclear receptor subfamily 1, group I, member 3
multiple interactions decreases expression
ISO
[GW 4064 co-treated with Oleic Acid] results in decreased expression of NR1I3 mRNA GW 4064 results in decreased expression of NR1I3 mRNA
CTD
PMID:30611723
NCBI chr 1:171,041,503...171,046,414
Ensembl chr 1:171,041,539...171,048,270
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Ntsr1
neurotensin receptor 1
decreases expression
EXP
GW 4064 results in decreased expression of NTSR1 mRNA
CTD
PMID:26655953
NCBI chr 2:180,141,769...180,186,772
Ensembl chr 2:180,141,769...180,186,773
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Nwd2
NACHT and WD repeat domain containing 2
decreases expression
EXP
GW 4064 results in decreased expression of NWD2 mRNA
CTD
PMID:26655953
NCBI chr 5:63,806,446...63,967,889
Ensembl chr 5:63,806,445...63,967,889
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Oas2
2'-5' oligoadenylate synthetase 2
decreases expression
EXP
GW 4064 results in decreased expression of OAS2 mRNA
CTD
PMID:26655953
NCBI chr 5:120,868,398...120,887,949
Ensembl chr 5:120,868,398...120,887,918
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Obp2a
odorant binding protein 2A
multiple interactions
EXP
[systhane co-treated with GW 4064] results in decreased expression of OBP2A mRNA
CTD
PMID:36511616
NCBI chr 2:25,587,589...25,593,338
Ensembl chr 2:25,590,055...25,593,338
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Olfml1
olfactomedin-like 1
increases expression
EXP
GW 4064 results in increased expression of OLFML1 mRNA
CTD
PMID:26655953
NCBI chr 7:107,166,640...107,190,572
Ensembl chr 7:107,166,653...107,190,301
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Or2l13b
olfactory receptor family 2 subfamily L member 13B
increases expression
EXP
GW 4064 results in increased expression of OR2L13B mRNA
CTD
PMID:26655953
NCBI chr16:19,348,730...19,349,668
Ensembl chr16:19,348,024...19,354,305
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Or5ac24
olfactory receptor family 5 subfamily AC member 24
increases expression
EXP
GW 4064 results in increased expression of OR5AC24 mRNA
CTD
PMID:26655953
NCBI chr16:59,165,085...59,166,089
Ensembl chr16:59,165,038...59,169,609
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Or5b94
olfactory receptor family 5 subfamily B member 94
decreases expression
EXP
GW 4064 results in decreased expression of OR5B94 mRNA
CTD
PMID:26655953
NCBI chr19:12,651,543...12,652,607
Ensembl chr19:12,647,803...12,654,641
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Orc1
origin recognition complex, subunit 1
increases expression
ISO
GW 4064 results in increased expression of ORC1 mRNA
CTD
PMID:31437187
NCBI chr 4:108,436,651...108,472,030
Ensembl chr 4:108,436,620...108,472,030
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Orc6
origin recognition complex, subunit 6
increases expression
ISO
GW 4064 results in increased expression of ORC6 mRNA
CTD
PMID:31437187
NCBI chr 8:86,026,261...86,034,908
Ensembl chr 8:86,026,261...86,034,907
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Orly
oppositely-transcribed, rearranged locus on the Y
decreases expression
EXP
GW 4064 results in decreased expression of ORLY mRNA
CTD
PMID:26655953
NCBI chr Y:78,575,974...78,586,678
Ensembl chr Y:70,015,477...70,026,168
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Osgin1
oxidative stress induced growth inhibitor 1
increases expression
EXP
GW 4064 results in increased expression of OSGIN1 mRNA
CTD
PMID:26655953
NCBI chr 8:120,160,874...120,172,996
Ensembl chr 8:120,160,863...120,172,995
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Pacs2
phosphofurin acidic cluster sorting protein 2
multiple interactions
EXP
GW 4064 inhibits the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of PACS2 mRNA]
CTD
PMID:28223344
NCBI chr12:112,977,998...113,038,021
Ensembl chr12:112,978,128...113,038,021
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Padi2
peptidyl arginine deiminase, type II
increases expression
EXP
GW 4064 results in increased expression of PADI2 mRNA
CTD
PMID:26655953
NCBI chr 4:140,633,685...140,679,897
Ensembl chr 4:140,633,655...140,679,897
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Parp1
poly (ADP-ribose) polymerase family, member 1
decreases phosphorylation
EXP
GW 4064 results in decreased phosphorylation of PARP1 protein
CTD
PMID:23178280
NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819
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Pbld2
phenazine biosynthesis-like protein domain containing 2
increases expression
EXP
GW 4064 results in increased expression of PBLD2 mRNA
CTD
PMID:26655953
NCBI chr10:62,858,319...62,894,592
Ensembl chr10:62,860,094...62,894,592
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Pcdh8
protocadherin 8
increases expression
EXP
GW 4064 results in increased expression of PCDH8 mRNA
CTD
PMID:26655953
NCBI chr14:80,004,224...80,008,752
Ensembl chr14:80,004,215...80,008,752
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Pck1
phosphoenolpyruvate carboxykinase 1, cytosolic
decreases expression multiple interactions
EXP ISO
GW 4064 results in decreased expression of PCK1 mRNA [GW 4064 co-treated with Oleic Acid] results in decreased expression of PCK1 mRNA
CTD
PMID:23371517 PMID:30611723
NCBI chr 2:172,994,866...173,001,067
Ensembl chr 2:172,994,841...173,001,066
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Pcx
pyruvate carboxylase
multiple interactions increases expression
EXP
GW 4064 inhibits the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased activity of PC protein]; GW 4064 promotes the reaction [NR1H4 protein binds to PCX gene] GW 4064 results in increased expression of PCX mRNA
CTD
PMID:20091679 PMID:26655953 PMID:28223344
NCBI chr19:4,560,500...4,671,780
Ensembl chr19:4,560,500...4,671,780
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Pde6h
phosphodiesterase 6H, cGMP-specific, cone, gamma
increases expression
EXP
GW 4064 results in increased expression of PDE6H mRNA
CTD
PMID:26655953
NCBI chr 6:136,929,216...136,940,483
Ensembl chr 6:136,900,830...136,945,863
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Pdgfrb
platelet derived growth factor receptor, beta polypeptide
multiple interactions
EXP
GW 4064 promotes the reaction [NR1H4 protein binds to PDGFRB gene]
CTD
PMID:20091679
NCBI chr18:61,178,194...61,218,139
Ensembl chr18:61,178,222...61,218,133
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Pdk4
pyruvate dehydrogenase kinase, isoenzyme 4
multiple interactions decreases expression
EXP ISO
NR1H4 gene mutant form inhibits the reaction [GW 4064 results in decreased expression of PDK4 mRNA]
CTD
PMID:25689681 PMID:31437187
NCBI chr 6:5,483,351...5,496,278
Ensembl chr 6:5,483,351...5,496,309
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Pdss1
prenyl (solanesyl) diphosphate synthase, subunit 1
decreases expression multiple interactions
ISO
GW 4064 results in decreased expression of PDSS1 mRNA [GW 4064 co-treated with Oleic Acid] results in decreased expression of PDSS1 mRNA
CTD
PMID:30611723
NCBI chr 2:22,784,393...22,830,273
Ensembl chr 2:22,785,534...22,830,278
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Pdxk
pyridoxal (pyridoxine, vitamin B6) kinase
increases expression
EXP
GW 4064 results in increased expression of PDXK mRNA
CTD
PMID:26655953
NCBI chr10:78,272,581...78,300,782
Ensembl chr10:78,272,578...78,300,809
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Pdzd2
PDZ domain containing 2
increases expression
EXP
GW 4064 results in increased expression of PDZD2 mRNA
CTD
PMID:26655953
NCBI chr15:12,359,797...12,740,052
Ensembl chr15:12,359,797...12,740,010
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Pecr
peroxisomal trans-2-enoyl-CoA reductase
multiple interactions
ISO
[GW 4064 co-treated with Oleic Acid] results in decreased expression of PECR mRNA
CTD
PMID:30611723
NCBI chr 1:72,298,331...72,323,480
Ensembl chr 1:72,298,326...72,323,473
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Pemt
phosphatidylethanolamine N-methyltransferase
multiple interactions decreases expression
EXP
NR0B2 protein promotes the reaction [GW 4064 results in decreased expression of PEMT mRNA]
CTD
PMID:29416063
NCBI chr11:59,861,440...59,937,394
Ensembl chr11:59,861,440...59,937,315
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Pgpep1l
pyroglutamyl-peptidase I-like
increases expression
EXP
GW 4064 results in increased expression of PGPEP1L mRNA
CTD
PMID:26655953
NCBI chr 7:67,881,154...67,914,232
Ensembl chr 7:67,886,358...67,913,981
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Phlda2
pleckstrin homology like domain, family A, member 2
increases expression
EXP
GW 4064 results in increased expression of PHLDA2 mRNA
CTD
PMID:26655953
NCBI chr 7:143,055,282...143,056,882
Ensembl chr 7:143,055,282...143,056,887
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Pianp
PILR alpha associated neural protein
decreases expression
EXP
GW 4064 results in decreased expression of PIANP mRNA
CTD
PMID:26655953
NCBI chr 6:124,973,683...124,980,059
Ensembl chr 6:124,973,657...124,980,059
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Pid1
phosphotyrosine interaction domain containing 1
decreases expression
EXP
GW 4064 results in decreased expression of PID1 mRNA
CTD
PMID:26655953
NCBI chr 1:84,014,014...84,317,550
Ensembl chr 1:84,014,017...84,341,901
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Pik3ap1
phosphoinositide-3-kinase adaptor protein 1
increases expression
EXP
GW 4064 results in increased expression of PIK3AP1 mRNA
CTD
PMID:26655953
NCBI chr19:41,260,980...41,373,541
Ensembl chr19:41,260,816...41,373,541
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Pla1a
phospholipase A1 member A
increases expression
EXP
GW 4064 results in increased expression of PLA1A mRNA
CTD
PMID:26655953
NCBI chr16:38,214,245...38,253,553
Ensembl chr16:38,216,479...38,253,507
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Pla2g12b
phospholipase A2, group XIIB
increases expression
EXP
GW 4064 results in increased expression of PLA2G12B mRNA
CTD
PMID:26655953
NCBI chr10:59,239,242...59,257,798
Ensembl chr10:59,239,482...59,257,798
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Plat
plasminogen activator, tissue
multiple interactions
EXP
GW 4064 promotes the reaction [NR1H4 protein binds to PLAT gene]
CTD
PMID:20091679
NCBI chr 8:23,247,655...23,272,864
Ensembl chr 8:23,247,743...23,272,860
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Plin2
perilipin 2
increases expression
ISO
GW 4064 results in increased expression of PLIN2 mRNA
CTD
PMID:30611723
NCBI chr 4:86,545,147...86,588,518
Ensembl chr 4:86,566,623...86,588,297
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Pllp
plasma membrane proteolipid
decreases expression
EXP
GW 4064 results in decreased expression of PLLP mRNA
CTD
PMID:26655953
NCBI chr 8:95,401,523...95,422,870
Ensembl chr 8:95,401,522...95,422,906
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Plpp6
phospholipid phosphatase 6
multiple interactions
ISO
[GW 4064 co-treated with Oleic Acid] results in decreased expression of PLPP6 mRNA
CTD
PMID:30611723
NCBI chr19:28,941,320...28,944,201
Ensembl chr19:28,941,353...28,944,211
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Pls1
plastin 1 (I-isoform)
increases expression
EXP
GW 4064 results in increased expression of PLS1 mRNA
CTD
PMID:26655953
NCBI chr 9:95,634,695...95,727,359
Ensembl chr 9:95,634,695...95,727,364
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Plxdc1
plexin domain containing 1
decreases expression
EXP
GW 4064 results in decreased expression of PLXDC1 mRNA
CTD
PMID:26655953
NCBI chr11:97,814,063...97,879,393
Ensembl chr11:97,814,064...97,877,270
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Pnpla3
patatin-like phospholipase domain containing 3
increases expression
EXP
GW 4064 results in increased expression of PNPLA3 mRNA
CTD
PMID:26655953
NCBI chr15:84,052,017...84,073,720
Ensembl chr15:84,052,038...84,071,437
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Pon1
paraoxonase 1
multiple interactions decreases expression
ISO
pyrazolanthrone inhibits the reaction [GW 4064 results in decreased expression of PON1 mRNA]
CTD
PMID:16269825
NCBI chr 6:5,168,101...5,193,824
Ensembl chr 6:5,168,090...5,193,946
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Pou5f1
POU domain, class 5, transcription factor 1
decreases expression
ISO
GW 4064 results in decreased expression of POU5F1 protein
CTD
PMID:31932555
NCBI chr17:35,816,929...35,821,674
Ensembl chr17:35,816,915...35,821,669
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Pp2d1
protein phosphatase 2C-like domain containing 1
decreases expression
EXP
GW 4064 results in decreased expression of PP2D1 mRNA
CTD
PMID:26655953
NCBI chr17:53,814,488...53,846,479
Ensembl chr17:53,814,488...53,846,479
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Ppara
peroxisome proliferator activated receptor alpha
increases expression multiple interactions affects expression
EXP ISO
GW 4064 results in increased expression of PPARA mRNA [GW 4064 co-treated with Oleic Acid] results in decreased expression of PPARA mRNA GW 4064 affects the expression of PPARA mRNA
CTD
PMID:15980055 PMID:26655953 PMID:30611723 PMID:31437187
NCBI chr15:85,619,112...85,691,052
Ensembl chr15:85,619,184...85,687,020
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Pparg
peroxisome proliferator activated receptor gamma
increases expression multiple interactions
ISO
GW 4064 results in increased expression of PPARG mRNA [GW 4064 co-treated with Oleic Acid] results in decreased expression of PPARG mRNA
CTD
PMID:15980055 PMID:30611723
NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360
G
Ppp1r10
protein phosphatase 1, regulatory subunit 10
decreases expression
EXP
GW 4064 results in decreased expression of PPP1R10 mRNA
CTD
PMID:26655953
NCBI chr17:36,227,404...36,243,175
Ensembl chr17:36,227,326...36,243,175
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Ppp1r3c
protein phosphatase 1, regulatory subunit 3C
decreases expression
EXP
GW 4064 results in decreased expression of PPP1R3C mRNA
CTD
PMID:26655953
NCBI chr19:36,709,131...36,714,004
Ensembl chr19:36,709,131...36,714,053
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Ppp1r3g
protein phosphatase 1, regulatory subunit 3G
decreases expression
EXP
GW 4064 results in decreased expression of PPP1R3G mRNA
CTD
PMID:26655953
NCBI chr13:36,142,816...36,154,371
Ensembl chr13:36,142,822...36,154,371
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Ppp2r2b
protein phosphatase 2, regulatory subunit B, beta
decreases expression
EXP
GW 4064 results in decreased expression of PPP2R2B mRNA
CTD
PMID:26655953
NCBI chr18:42,777,811...43,192,827
Ensembl chr18:42,770,497...43,216,192
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Ppp4r4
protein phosphatase 4, regulatory subunit 4
decreases expression
EXP
GW 4064 results in decreased expression of PPP4R4 mRNA
CTD
PMID:26655953
NCBI chr12:103,498,509...103,580,098
Ensembl chr12:103,498,542...103,580,090
G
Prl6a1
prolactin family 6, subfamily a, member 1
decreases expression
EXP
GW 4064 results in decreased expression of PRL6A1 mRNA
CTD
PMID:26655953
NCBI chr13:27,496,598...27,503,237
Ensembl chr13:27,496,610...27,503,235
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Prodh2
proline dehydrogenase (oxidase) 2
increases expression
EXP
GW 4064 results in increased expression of PRODH2 mRNA
CTD
PMID:26655953
NCBI chr 7:30,193,011...30,212,830
Ensembl chr 7:30,193,047...30,212,827
G
Prom2
prominin 2
decreases expression
EXP
GW 4064 results in decreased expression of PROM2 mRNA
CTD
PMID:26655953
NCBI chr 2:127,368,873...127,383,337
Ensembl chr 2:127,368,393...127,383,387
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Prr15
proline rich 15
decreases expression
EXP
GW 4064 results in decreased expression of PRR15 mRNA
CTD
PMID:26655953
NCBI chr 6:54,290,442...54,320,421
Ensembl chr 6:54,302,820...54,307,186
G
Ptger3
prostaglandin E receptor 3 (subtype EP3)
decreases expression
EXP
GW 4064 results in decreased expression of PTGER3 mRNA
CTD
PMID:26655953
NCBI chr 3:157,272,459...157,350,392
Ensembl chr 3:157,272,529...157,351,525
G
Ptgfr
prostaglandin F receptor
decreases expression
EXP
GW 4064 results in decreased expression of PTGFR mRNA
CTD
PMID:26655953
NCBI chr 3:151,504,247...151,543,165
Ensembl chr 3:151,502,139...151,543,267
G
Ptprr
protein tyrosine phosphatase receptor type R
increases expression
EXP
GW 4064 results in increased expression of PTPRR mRNA
CTD
PMID:26655953
NCBI chr10:115,854,093...116,110,837
Ensembl chr10:115,854,118...116,110,837
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Rab11fip4
RAB11 family interacting protein 4 (class II)
increases expression
EXP
GW 4064 results in increased expression of RAB11FIP4 mRNA
CTD
PMID:26655953
NCBI chr11:79,481,847...79,588,842
Ensembl chr11:79,482,038...79,588,849
G
Rab38
RAB38, member RAS oncogene family
increases expression
EXP
GW 4064 results in increased expression of RAB38 mRNA
CTD
PMID:26655953
NCBI chr 7:88,079,481...88,140,780
Ensembl chr 7:88,079,481...88,140,780
G
Rabggta
Rab geranylgeranyl transferase, a subunit
multiple interactions
ISO
[GW 4064 co-treated with Oleic Acid] results in decreased expression of RABGGTA mRNA
CTD
PMID:30611723
NCBI chr14:55,953,321...55,959,720
Ensembl chr14:55,952,873...55,959,720
G
Rabggtb
Rab geranylgeranyl transferase, b subunit
multiple interactions
ISO
[GW 4064 co-treated with Oleic Acid] results in decreased expression of RABGGTB mRNA
CTD
PMID:30611723
NCBI chr 3:153,612,926...153,618,603
Ensembl chr 3:153,612,924...153,618,646
G
Rarres2
retinoic acid receptor responder (tazarotene induced) 2
increases expression multiple interactions
EXP
GW 4064 results in increased expression of RARRES2 mRNA GW 4064 promotes the reaction [NR1H4 protein binds to RARRES2 gene]
CTD
PMID:20091679 PMID:26655953
NCBI chr 6:48,546,630...48,549,778
Ensembl chr 6:48,546,630...48,549,723
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Rasgrp1
RAS guanyl releasing protein 1
decreases expression
EXP
GW 4064 results in decreased expression of RASGRP1 mRNA
CTD
PMID:26655953
NCBI chr 2:117,110,464...117,173,358
Ensembl chr 2:117,110,474...117,173,482
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Rb1
RB transcriptional corepressor 1
increases phosphorylation
ISO
GW 4064 results in increased phosphorylation of RB1 protein
CTD
PMID:31437187
NCBI chr14:73,430,298...73,563,446
Ensembl chr14:73,421,113...73,563,262
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Rbp4
retinol binding protein 4, plasma
increases expression
EXP
GW 4064 results in increased expression of RBP4 mRNA
CTD
PMID:26655953
NCBI chr19:38,105,068...38,113,769
Ensembl chr19:38,105,077...38,113,729
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Reep6
receptor accessory protein 6
increases expression
EXP
GW 4064 results in increased expression of REEP6 mRNA
CTD
PMID:26655953
NCBI chr10:80,165,831...80,172,275
Ensembl chr10:80,165,787...80,172,275
G
Rfx5
regulatory factor X, 5 (influences HLA class II expression)
increases expression
EXP
GW 4064 results in increased expression of RFX5 mRNA
CTD
PMID:26655953
NCBI chr 3:94,861,355...94,868,685
Ensembl chr 3:94,861,386...94,868,872
G
Rhcg
Rhesus blood group-associated C glycoprotein
decreases expression
EXP
GW 4064 results in decreased expression of RHCG mRNA
CTD
PMID:26655953
NCBI chr 7:79,243,111...79,267,405
Ensembl chr 7:79,243,111...79,267,405
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Rnase4
ribonuclease, RNase A family 4
increases expression
EXP
GW 4064 results in increased expression of RNASE4 mRNA
CTD
PMID:26655953
NCBI chr14:51,328,534...51,343,608
Ensembl chr14:51,328,534...51,343,608
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Rnf152
ring finger protein 152
increases expression
EXP
GW 4064 results in increased expression of RNF152 mRNA
CTD
PMID:26655953
NCBI chr 1:105,204,642...105,284,665
Ensembl chr 1:105,204,639...105,284,435
G
Rpl3l
ribosomal protein L3-like
decreases expression
EXP
GW 4064 results in decreased expression of RPL3L mRNA
CTD
PMID:26655953
NCBI chr17:24,946,800...24,955,117
Ensembl chr17:24,946,794...24,955,117
G
Rprm
reprimo, TP53 dependent G2 arrest mediator candidate
decreases expression
EXP
GW 4064 results in decreased expression of RPRM mRNA
CTD
PMID:26655953
NCBI chr 2:53,974,105...53,975,564
Ensembl chr 2:53,974,105...53,975,564
G
Rsad2
radical S-adenosyl methionine domain containing 2
decreases expression
EXP
GW 4064 results in decreased expression of RSAD2 mRNA
CTD
PMID:26655953
NCBI chr12:26,492,742...26,506,451
Ensembl chr12:26,492,745...26,506,451
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Rtl5
retrotransposon Gag like 5
increases expression
EXP
GW 4064 results in increased expression of RTL5 mRNA
CTD
PMID:26655953
NCBI chr X:101,110,148...101,114,942
Ensembl chr X:101,110,150...101,114,910
G
Runx1t1
RUNX1 translocation partner 1
increases expression
EXP
GW 4064 results in increased expression of RUNX1T1 mRNA
CTD
PMID:26655953
NCBI chr 4:13,742,628...13,895,056
Ensembl chr 4:13,743,436...13,893,649
G
Satb2
special AT-rich sequence binding protein 2
increases expression
EXP
GW 4064 results in increased expression of SATB2 mRNA
CTD
PMID:26655953
NCBI chr 1:56,833,145...57,019,350
Ensembl chr 1:56,833,140...57,017,809
G
Scarb1
scavenger receptor class B, member 1
multiple interactions increases expression
EXP ISO
[GW 4064 binds to and results in increased activity of NR1H4 protein] which results in increased expression of SCARB1 mRNA; FGF15 gene mutant form inhibits the reaction [GW 4064 results in increased expression of SCARB1 mRNA]; GW 4064 promotes the reaction [NR1H4 protein binds to SCARB1 intron]
CTD
PMID:22540009 PMID:30996006
NCBI chr 5:125,354,151...125,418,082
Ensembl chr 5:125,354,151...125,418,158
G
Scd2
stearoyl-Coenzyme A desaturase 2
multiple interactions decreases expression
ISO
[GW 4064 co-treated with Oleic Acid] results in decreased expression of SCD mRNA GW 4064 results in decreased expression of SCD mRNA
CTD
PMID:30611723
NCBI chr19:44,282,115...44,295,303
Ensembl chr19:44,282,113...44,295,303
G
Scd3
stearoyl-coenzyme A desaturase 3
multiple interactions
ISO
[GW 4064 co-treated with Oleic Acid] results in decreased expression of SCD5 mRNA
CTD
PMID:30611723
NCBI chr19:44,191,727...44,232,455
Ensembl chr19:44,191,708...44,232,455
G
Scp2
sterol carrier protein 2, liver
multiple interactions
ISO
[GW 4064 co-treated with Oleic Acid] results in decreased expression of SCP2 mRNA
CTD
PMID:30611723
NCBI chr 4:107,901,027...108,002,168
Ensembl chr 4:107,901,036...108,002,195
G
Sectm1b
secreted and transmembrane 1B
increases expression
EXP
GW 4064 results in increased expression of SECTM1B mRNA
CTD
PMID:26655953
NCBI chr11:120,944,248...120,954,377
Ensembl chr11:120,944,284...120,954,395
G
Sema3c
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
increases expression
EXP
GW 4064 results in increased expression of SEMA3C mRNA
CTD
PMID:26655953
NCBI chr 5:17,779,814...17,935,266
Ensembl chr 5:17,779,279...17,935,266
G
Sema4g
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
increases expression
EXP
GW 4064 results in increased expression of SEMA4G mRNA
CTD
PMID:26655953
NCBI chr19:44,976,838...44,991,836
Ensembl chr19:44,977,540...44,991,836
G
Sema5b
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B
increases expression
EXP
GW 4064 results in increased expression of SEMA5B mRNA
CTD
PMID:26655953
NCBI chr16:35,361,517...35,485,103
Ensembl chr16:35,361,515...35,485,102
G
Serpina1a
serine (or cysteine) peptidase inhibitor, clade A, member 1A
increases expression
EXP
GW 4064 results in increased expression of SERPINA1A mRNA
CTD
PMID:26655953
NCBI chr12:103,819,554...103,829,878
Ensembl chr12:103,819,848...103,829,821
G
Serpina1c
serine (or cysteine) peptidase inhibitor, clade A, member 1C
increases expression
EXP
GW 4064 results in increased expression of SERPINA1C mRNA
CTD
PMID:26655953
NCBI chr12:103,861,185...103,871,209
Ensembl chr12:103,861,185...103,871,146
G
Serpina1d
serine (or cysteine) peptidase inhibitor, clade A, member 1D
increases expression
EXP
GW 4064 results in increased expression of SERPINA1D mRNA
CTD
PMID:26655953
NCBI chr12:103,729,846...103,739,892
Ensembl chr12:103,729,853...103,739,851
G
Serpina1e
serine (or cysteine) peptidase inhibitor, clade A, member 1E
increases expression
EXP
GW 4064 results in increased expression of SERPINA1E mRNA
CTD
PMID:26655953
NCBI chr12:103,913,190...103,923,156
Ensembl chr12:103,913,190...103,925,234
G
Serpina3i
serine (or cysteine) peptidase inhibitor, clade A, member 3I
decreases expression
EXP
GW 4064 results in decreased expression of SERPINA3I mRNA
CTD
PMID:26655953
NCBI chr12:104,229,304...104,235,768
Ensembl chr12:104,229,381...104,235,631
G
Serpina3n
serine (or cysteine) peptidase inhibitor, clade A, member 3N
decreases expression
EXP
GW 4064 results in decreased expression of SERPINA3N mRNA
CTD
PMID:26655953
NCBI chr12:104,372,967...104,380,588
Ensembl chr12:104,372,988...104,380,588
G
Serpina4-ps1
serine (or cysteine) peptidase inhibitor, clade A, member 4, pseudogene 1
increases expression
EXP
GW 4064 results in increased expression of SERPINA4-PS1 mRNA
CTD
PMID:26655953
NCBI chr12:104,044,218...104,053,179
Ensembl chr12:104,046,908...104,052,983
G
Serpina6
serine (or cysteine) peptidase inhibitor, clade A, member 6
decreases expression
EXP
GW 4064 results in decreased expression of SERPINA6 mRNA
CTD
PMID:26655953
NCBI chr12:103,612,889...103,623,477
Ensembl chr12:103,612,889...103,623,471
G
Serpinf2
serine (or cysteine) peptidase inhibitor, clade F, member 2
increases expression
EXP
GW 4064 results in increased expression of SERPINF2 mRNA
CTD
PMID:26655953
NCBI chr11:75,322,562...75,330,327
Ensembl chr11:75,322,558...75,330,417
G
Sfn
stratifin
increases expression
ISO
GW 4064 results in increased expression of SFN mRNA
CTD
PMID:31437187
NCBI chr 4:133,327,867...133,329,163
Ensembl chr 4:133,327,867...133,329,479
G
Sgk2
serum/glucocorticoid regulated kinase 2
increases expression
EXP
GW 4064 results in increased expression of SGK2 mRNA
CTD
PMID:26655953
NCBI chr 2:162,829,249...162,856,059
Ensembl chr 2:162,829,250...162,856,047
G
Shank2
SH3 and multiple ankyrin repeat domains 2
increases expression
EXP
GW 4064 results in increased expression of SHANK2 mRNA
CTD
PMID:26655953
NCBI chr 7:143,531,819...143,979,780
Ensembl chr 7:143,555,665...143,978,231
G
Shisa9
shisa family member 9
decreases expression
EXP
GW 4064 results in decreased expression of SHISA9 mRNA
CTD
PMID:26655953
NCBI chr16:11,801,457...12,088,768
Ensembl chr16:11,801,977...12,088,766
G
Sirt1
sirtuin 1
multiple interactions
EXP
GW 4064 inhibits the reaction [Oleanolic Acid results in decreased expression of SIRT1 protein]
CTD
PMID:37028458
NCBI chr10:63,154,784...63,174,814
Ensembl chr10:63,154,784...63,217,483
G
Skp2
S-phase kinase-associated protein 2
increases expression
ISO
GW 4064 results in increased expression of SKP2 mRNA
CTD
PMID:31437187
NCBI chr15:9,112,070...9,155,512
Ensembl chr15:9,112,073...9,155,512
G
Slc10a1
solute carrier family 10 (sodium/bile acid cotransporter family), member 1
multiple interactions increases expression decreases expression
EXP ISO
[GW 4064 binds to and results in increased activity of NR1H4 protein] which results in decreased expression of SLC10A1 mRNA; GW 4064 promotes the reaction [NR1H4 protein binds to SLC10A1 gene] GW 4064 results in increased expression of SLC10A1 mRNA; GW 4064 results in increased expression of SLC10A1 protein GW 4064 results in decreased expression of SLC10A1 mRNA
CTD
PMID:14623915 PMID:15644430 PMID:20091679 PMID:22540009 PMID:27609522
NCBI chr12:80,999,959...81,015,479
Ensembl chr12:80,999,957...81,015,479
G
Slc10a2
solute carrier family 10, member 2
multiple interactions
ISO
GW 4064 inhibits the reaction [deoxynivalenol results in decreased expression of SLC10A2 mRNA]
CTD
PMID:35224661
NCBI chr 8:5,133,219...5,155,287
Ensembl chr 8:5,133,219...5,155,351
G
Slc12a3
solute carrier family 12, member 3
decreases expression
EXP
GW 4064 results in decreased expression of SLC12A3 mRNA
CTD
PMID:26655953
NCBI chr 8:95,055,737...95,092,850
Ensembl chr 8:95,055,829...95,092,842
G
Slc13a1
solute carrier family 13 (sodium/sulfate symporters), member 1
increases expression
EXP
GW 4064 results in increased expression of SLC13A1 mRNA
CTD
PMID:26655953
NCBI chr 6:24,088,282...24,168,118
Ensembl chr 6:24,088,282...24,168,091
G
Slc13a2
solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2
increases expression
EXP
GW 4064 results in increased expression of SLC13A2 mRNA
CTD
PMID:26655953
NCBI chr11:78,288,102...78,313,107
Ensembl chr11:78,287,913...78,313,043
G
Slc13a3
solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3
increases expression
EXP
GW 4064 results in increased expression of SLC13A3 mRNA
CTD
PMID:26655953
NCBI chr 2:165,247,215...165,315,117
Ensembl chr 2:165,246,948...165,315,150
G
Slc13a5
solute carrier family 13 (sodium-dependent citrate transporter), member 5
decreases expression
EXP
GW 4064 results in decreased expression of SLC13A5 mRNA
CTD
PMID:26655953
NCBI chr11:72,132,816...72,158,092
Ensembl chr11:72,132,815...72,158,048
G
Slc16a14
solute carrier family 16 (monocarboxylic acid transporters), member 14
decreases expression
EXP
GW 4064 results in decreased expression of SLC16A14 mRNA
CTD
PMID:26655953
NCBI chr 1:84,881,344...84,912,927
Ensembl chr 1:84,883,619...84,912,855
G
Slc16a3
solute carrier family 16 (monocarboxylic acid transporters), member 3
decreases expression
EXP
GW 4064 results in decreased expression of SLC16A3 mRNA
CTD
PMID:26655953
NCBI chr11:120,839,310...120,849,826
Ensembl chr11:120,839,306...120,851,694
G
Slc17a1
solute carrier family 17 (sodium phosphate), member 1
increases expression
EXP
GW 4064 results in increased expression of SLC17A1 mRNA
CTD
PMID:26655953
NCBI chr13:24,051,607...24,079,713
Ensembl chr13:24,051,733...24,079,713
G
Slc17a3
solute carrier family 17 (sodium phosphate), member 3
increases expression
EXP
GW 4064 results in increased expression of SLC17A3 mRNA
CTD
PMID:26655953
NCBI chr13:24,020,905...24,044,701
Ensembl chr13:24,023,417...24,044,699
G
Slc17a4
solute carrier family 17 (sodium phosphate), member 4
increases expression
EXP
GW 4064 results in increased expression of SLC17A4 mRNA
CTD
PMID:26655953
NCBI chr13:24,081,862...24,098,992
Ensembl chr13:24,079,873...24,098,992
G
Slc18a1
solute carrier family 18 (vesicular monoamine), member 1
increases expression
EXP
GW 4064 results in increased expression of SLC18A1 mRNA
CTD
PMID:26655953
NCBI chr 8:69,490,360...69,547,951
Ensembl chr 8:69,490,363...69,541,887
G
Slc19a3
solute carrier family 19, member 3
increases expression
EXP
GW 4064 results in increased expression of SLC19A3 mRNA
CTD
PMID:26655953
NCBI chr 1:82,990,242...83,016,541
Ensembl chr 1:82,990,244...83,016,169
G
Slc22a21
solute carrier family 22 (organic cation transporter), member 21
multiple interactions
EXP
GW 4064 promotes the reaction [NR1H4 protein binds to SLC22A21 gene]
CTD
PMID:20091679
NCBI chr11:53,840,780...53,871,159
Ensembl chr11:53,840,791...53,871,158
G
Slc22a6
solute carrier family 22 (organic anion transporter), member 6
increases expression
EXP
GW 4064 results in increased expression of SLC22A6 mRNA
CTD
PMID:26655953
NCBI chr19:8,595,360...8,605,663
Ensembl chr19:8,595,403...8,605,663
G
Slc22a8
solute carrier family 22 (organic anion transporter), member 8
increases expression
EXP
GW 4064 results in increased expression of SLC22A8 mRNA
CTD
PMID:26655953
NCBI chr19:8,568,576...8,589,199
Ensembl chr19:8,568,618...8,589,199
G
Slc25a15
solute carrier family 25 (mitochondrial carrier ornithine transporter), member 15
increases expression
EXP
GW 4064 results in increased expression of SLC25A15 mRNA
CTD
PMID:26655953
NCBI chr 8:22,865,566...22,888,637
Ensembl chr 8:22,865,567...22,888,613
G
Slc25a20
solute carrier family 25 (mitochondrial carnitine/acylcarnitine translocase), member 20
multiple interactions
ISO
[GW 4064 co-treated with Oleic Acid] results in decreased expression of SLC25A20 mRNA
CTD
PMID:30611723
NCBI chr 9:108,539,335...108,561,841
Ensembl chr 9:108,539,287...108,561,840
G
Slc25a3
solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 3
multiple interactions
EXP
GW 4064 promotes the reaction [NR1H4 protein binds to SLC25A3 gene]
CTD
PMID:20091679
NCBI chr10:90,952,436...90,959,902
Ensembl chr10:90,952,436...90,959,921
G
Slc25a43
solute carrier family 25, member 43
increases expression
EXP
GW 4064 results in increased expression of SLC25A43 mRNA
CTD
PMID:26655953
NCBI chr X:36,007,223...36,040,960
Ensembl chr X:36,007,312...36,040,855
G
Slc26a6
solute carrier family 26, member 6
increases expression
EXP
GW 4064 results in increased expression of SLC26A6 mRNA
CTD
PMID:26655953
NCBI chr 9:108,731,239...108,742,117
Ensembl chr 9:108,730,482...108,742,117
G
Slc27a1
solute carrier family 27 (fatty acid transporter), member 1
multiple interactions
ISO
[GW 4064 co-treated with Oleic Acid] results in decreased expression of SLC27A1 mRNA
CTD
PMID:30611723
NCBI chr 8:72,021,372...72,039,951
Ensembl chr 8:72,021,526...72,039,946
G
Slc27a2
solute carrier family 27 (fatty acid transporter), member 2
increases expression multiple interactions
ISO
GW 4064 results in increased expression of SLC27A2 mRNA [GW 4064 co-treated with Oleic Acid] results in decreased expression of SLC27A2 mRNA
CTD
PMID:30611723
NCBI chr 2:126,394,944...126,430,163
Ensembl chr 2:126,394,327...126,430,163
G
Slc27a5
solute carrier family 27 (fatty acid transporter), member 5
increases expression
EXP
GW 4064 results in increased expression of SLC27A5 mRNA
CTD
PMID:27609522
NCBI chr 7:12,722,273...12,732,119
Ensembl chr 7:12,722,273...12,732,119
G
Slc2a5
solute carrier family 2 (facilitated glucose transporter), member 5
increases expression
EXP
GW 4064 results in increased expression of SLC2A5 mRNA
CTD
PMID:26655953
NCBI chr 4:150,203,801...150,228,625
Ensembl chr 4:150,203,740...150,228,626
G
Slc35f3
solute carrier family 35, member F3
decreases expression
EXP
GW 4064 results in decreased expression of SLC35F3 mRNA
CTD
PMID:26655953
NCBI chr 8:126,865,155...127,122,726
Ensembl chr 8:126,865,734...127,122,717
G
Slc39a5
solute carrier family 39 (metal ion transporter), member 5
increases expression
EXP
GW 4064 results in increased expression of SLC39A5 mRNA
CTD
PMID:26655953
NCBI chr10:128,231,796...128,237,145
Ensembl chr10:128,231,800...128,237,098
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Slc3a1
solute carrier family 3, member 1
increases expression
EXP
GW 4064 results in increased expression of SLC3A1 mRNA
CTD
PMID:26655953
NCBI chr17:85,335,775...85,371,669
Ensembl chr17:85,335,804...85,371,664
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Slc51a
solute carrier family 51, alpha subunit
multiple interactions increases expression
ISO EXP
Clavulanic Acid inhibits the reaction [GW 4064 results in increased expression of SLC51A mRNA]; epigallocatechin gallate inhibits the reaction [GW 4064 results in increased expression of SLC51A mRNA] [GW 4064 co-treated with Dietary Fats] results in decreased expression of SLC51A mRNA; GW 4064 inhibits the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of SLC51A mRNA]; GW 4064 promotes the reaction [NR1H4 protein binds to SLC51A gene]
CTD
PMID:20091679 PMID:22178739 PMID:26655953 PMID:27609522 PMID:28223344 PMID:34767876 PMID:35224661 More...
NCBI chr16:32,294,396...32,306,697
Ensembl chr16:32,293,322...32,306,697
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Slc51b
solute carrier family 51, beta subunit
increases expression multiple interactions
ISO EXP
GW 4064 results in increased expression of SLC51B mRNA [GW 4064 binds to and results in increased activity of NR1H4 protein] which results in increased expression of SLC51B mRNA; [GW 4064 co-treated with Dietary Fats] results in decreased expression of SLC51B mRNA; GW 4064 inhibits the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of SLC51B mRNA]; GW 4064 promotes the reaction [NR1H4 protein binds to SLC51B gene] epigallocatechin gallate inhibits the reaction [GW 4064 results in increased expression of SLC51B mRNA]
CTD
PMID:20091679 PMID:22178739 PMID:22540009 PMID:23178280 PMID:26655953 PMID:27609522 PMID:28223344 More...
NCBI chr 9:65,320,035...65,330,055
Ensembl chr 9:65,319,996...65,330,237
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Slc5a1
solute carrier family 5 (sodium/glucose cotransporter), member 1
increases expression
EXP
GW 4064 results in increased expression of SLC5A1 mRNA
CTD
PMID:26655953
NCBI chr 5:33,261,563...33,320,043
Ensembl chr 5:33,261,563...33,320,214
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Slc5a9
solute carrier family 5 (sodium/glucose cotransporter), member 9
increases expression
EXP
GW 4064 results in increased expression of SLC5A9 mRNA
CTD
PMID:26655953
NCBI chr 4:111,732,571...111,759,993
Ensembl chr 4:111,732,572...111,760,115
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Slc6a13
solute carrier family 6 (neurotransmitter transporter, GABA), member 13
increases expression
EXP
GW 4064 results in increased expression of SLC6A13 mRNA
CTD
PMID:26655953
NCBI chr 6:121,277,247...121,314,680
Ensembl chr 6:121,277,186...121,314,692
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Slc6a20b
solute carrier family 6 (neurotransmitter transporter), member 20B
increases expression
EXP
GW 4064 results in increased expression of SLC6A20B mRNA
CTD
PMID:26655953
NCBI chr 9:123,422,888...123,461,603
Ensembl chr 9:123,419,865...123,461,630
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Slc7a9
solute carrier family 7 (cationic amino acid transporter, y+ system), member 9
increases expression
EXP
GW 4064 results in increased expression of SLC7A9 mRNA
CTD
PMID:26655953
NCBI chr 7:35,148,152...35,165,459
Ensembl chr 7:35,148,221...35,165,461
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Slc9a3
solute carrier family 9 (sodium/hydrogen exchanger), member 3
decreases expression
EXP
GW 4064 results in decreased expression of SLC9A3 mRNA
CTD
PMID:26655953
NCBI chr13:74,234,374...74,317,561
Ensembl chr13:74,269,576...74,317,561
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Slc9a8
solute carrier family 9 (sodium/hydrogen exchanger), member 8
multiple interactions
EXP
GW 4064 promotes the reaction [NR1H4 protein binds to SLC9A8 gene]
CTD
PMID:20091679
NCBI chr 2:167,261,678...167,318,920
Ensembl chr 2:167,263,632...167,318,920
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Slco1a4
solute carrier organic anion transporter family, member 1a4
increases expression multiple interactions
ISO
GW 4064 increases expression of Slco1a4 mRNA in primary hepatocytes GW 4064 inhibits the reaction [17alpha-ethynylestradiol decreases expression of Slco1a4 mRNA in primary hepatocytes] GW 4064 inhibits the reaction [Ethinyl Estradiol results in decreased expression of SLCO1A2 mRNA]
CTD RGD
PMID:27090119 PMID:27090119 PMID:27090119
RGD:15090804 , RGD:15090804
NCBI chr 6:141,751,164...141,802,011
Ensembl chr 6:141,751,166...141,801,925
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Slco1b2
solute carrier organic anion transporter family, member 1b2
increases expression
EXP
GW 4064 results in increased expression of SLCO1B2 mRNA
CTD
PMID:27609522
NCBI chr 6:141,575,178...141,632,372
Ensembl chr 6:141,575,244...141,632,372
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Smad9
SMAD family member 9
decreases expression
EXP
GW 4064 results in decreased expression of SMAD9 mRNA
CTD
PMID:26655953
NCBI chr 3:54,662,873...54,709,162
Ensembl chr 3:54,663,003...54,708,678
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Smim27
small integral membrane protein 27
increases expression
EXP
GW 4064 results in increased expression of SMIM27 mRNA
CTD
PMID:26655953
NCBI chr 4:40,269,579...40,270,228
Ensembl chr 4:40,269,579...40,270,940
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Smlr1
small leucine-rich protein 1
increases expression
EXP
GW 4064 results in increased expression of SMLR1 mRNA
CTD
PMID:26655953
NCBI chr10:25,403,841...25,412,170
Ensembl chr10:25,403,841...25,412,165
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Smpd3
sphingomyelin phosphodiesterase 3, neutral
multiple interactions
EXP
GW 4064 inhibits the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of SMPD3 mRNA]
CTD
PMID:28223344
NCBI chr 8:106,979,180...107,064,597
Ensembl chr 8:106,979,180...107,064,620
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Smpd4
sphingomyelin phosphodiesterase 4
multiple interactions
EXP
GW 4064 inhibits the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of SMPD4 mRNA]
CTD
PMID:28223344
NCBI chr16:17,437,218...17,462,694
Ensembl chr16:17,437,218...17,462,692
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Snap91
synaptosomal-associated protein 91
decreases expression
EXP
GW 4064 results in decreased expression of SNAP91 mRNA
CTD
PMID:26655953
NCBI chr 9:86,647,976...86,762,766
Ensembl chr 9:86,647,976...86,762,707
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Soat2
sterol O-acyltransferase 2
increases expression
EXP
GW 4064 results in increased expression of SOAT2 mRNA
CTD
PMID:26655953
NCBI chr15:102,058,853...102,071,871
Ensembl chr15:102,058,961...102,071,904
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Sod3
superoxide dismutase 3, extracellular
multiple interactions increases expression
ISO EXP
GW 4064 promotes the reaction [NR1H4 protein binds to SOD3 promoter]; SOD3 promotes the reaction [GW 4064 inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein]]; SOD3 promotes the reaction [GW 4064 inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK9 protein]] GW 4064 results in increased expression of SOD3 mRNA NR1H4 gene mutant form inhibits the reaction [GW 4064 results in increased expression of SOD3 mRNA]
CTD
PMID:25496033
NCBI chr 5:52,521,146...52,527,080
Ensembl chr 5:52,521,133...52,528,760
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Sox18
SRY (sex determining region Y)-box 18
increases expression
EXP
GW 4064 results in increased expression of SOX18 mRNA
CTD
PMID:26655953
NCBI chr 2:181,311,630...181,313,433
Ensembl chr 2:181,311,629...181,313,433
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Sp8
trans-acting transcription factor 8
increases expression
EXP
GW 4064 results in increased expression of SP8 mRNA
CTD
PMID:26655953
NCBI chr12:118,809,968...118,816,313
Ensembl chr12:118,810,064...118,816,311
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Spp2
secreted phosphoprotein 2
increases expression
EXP
GW 4064 results in increased expression of SPP2 mRNA
CTD
PMID:26655953
NCBI chr 1:88,334,688...88,356,022
Ensembl chr 1:88,334,683...88,354,160
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Sprr2f
small proline-rich protein 2F
decreases expression
EXP
GW 4064 results in decreased expression of SPRR2F mRNA
CTD
PMID:26655953
NCBI chr 3:92,272,494...92,273,754
Ensembl chr 3:92,272,494...92,273,749
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Sprr2g
small proline-rich protein 2G
decreases expression
EXP
GW 4064 results in decreased expression of SPRR2G mRNA
CTD
PMID:26655953
NCBI chr 3:92,281,222...92,282,536
Ensembl chr 3:92,281,222...92,282,536
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Sptlc2
serine palmitoyltransferase, long chain base subunit 2
multiple interactions
EXP
GW 4064 inhibits the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of SPTLC2 mRNA]
CTD
PMID:28223344
NCBI chr12:87,351,832...87,435,129
Ensembl chr12:87,351,832...87,435,129
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Sqstm1
sequestosome 1
increases expression
EXP
GW 4064 results in increased expression of SQSTM1 mRNA; GW 4064 results in increased expression of SQSTM1 protein
CTD
PMID:22952826
NCBI chr11:50,090,979...50,105,303
Ensembl chr11:50,090,193...50,101,654
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Srebf1
sterol regulatory element binding transcription factor 1
decreases expression multiple interactions
ISO
GW 4064 results in decreased expression of SREBF1 mRNA [GW 4064 co-treated with Oleic Acid] results in decreased expression of SREBF1 mRNA
CTD
PMID:16269825 PMID:30611723
NCBI chr11:60,089,910...60,113,407
Ensembl chr11:60,089,915...60,113,407
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Srl
sarcalumenin
increases expression
EXP
GW 4064 results in increased expression of SRL mRNA
CTD
PMID:26655953
NCBI chr16:4,294,843...4,359,772
Ensembl chr16:4,298,080...4,359,680
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St3gal5
ST3 beta-galactoside alpha-2,3-sialyltransferase 5
increases expression
EXP
GW 4064 results in increased expression of ST3GAL5 mRNA
CTD
PMID:26655953
NCBI chr 6:72,074,555...72,131,555
Ensembl chr 6:72,074,576...72,131,555
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St8sia6
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6
decreases expression
EXP
GW 4064 results in decreased expression of ST8SIA6 mRNA
CTD
PMID:26655953
NCBI chr 2:13,659,745...13,798,659
Ensembl chr 2:13,655,832...13,798,875
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Stat2
signal transducer and activator of transcription 2
multiple interactions
EXP
GW 4064 promotes the reaction [NR1H4 protein binds to STAT2 gene]
CTD
PMID:20091679
NCBI chr10:128,106,367...128,128,722
Ensembl chr10:128,106,428...128,128,718
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Stc2
stanniocalcin 2
increases expression
EXP
GW 4064 results in increased expression of STC2 mRNA
CTD
PMID:26655953
NCBI chr11:31,309,441...31,320,061
Ensembl chr11:31,307,307...31,320,074
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Stk32a
serine/threonine kinase 32A
decreases expression
EXP
GW 4064 results in decreased expression of STK32A mRNA
CTD
PMID:26655953
NCBI chr18:43,340,762...43,450,546
Ensembl chr18:43,340,648...43,451,747
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Stkld1
serine/threonine kinase-like domain containing 1
increases expression
EXP
GW 4064 results in increased expression of STKLD1 mRNA
CTD
PMID:26655953
NCBI chr 2:26,823,533...26,843,508
Ensembl chr 2:26,824,059...26,843,508
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Stra6l
STRA6-like
increases expression
EXP
GW 4064 results in increased expression of STRA6L mRNA
CTD
PMID:26655953
NCBI chr 4:45,818,940...45,887,010
Ensembl chr 4:45,848,664...45,887,008
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Stra8
stimulated by retinoic acid gene 8
multiple interactions decreases expression
EXP
bisphenol A inhibits the reaction [GW 4064 results in decreased expression of STRA8 mRNA]; GW 4064 inhibits the reaction [bisphenol A results in decreased expression of STRA8 mRNA]; GW 4064 inhibits the reaction [Stigmasterol results in decreased expression of STRA8 mRNA]; NR1H4 gene mutant form inhibits the reaction [GW 4064 results in decreased expression of STRA8 mRNA]; Stigmasterol inhibits the reaction [GW 4064 results in decreased expression of STRA8 mRNA]
CTD
PMID:30245210
NCBI chr 6:34,897,098...34,916,279
Ensembl chr 6:34,897,098...34,916,279
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Sult2a1
sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
decreases expression
ISO
GW 4064 results in decreased expression of SULT2A1 mRNA
CTD
PMID:16946559
NCBI chr 7:13,530,171...13,571,335
Ensembl chr 7:13,530,171...13,571,334
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Sult5a1
sulfotransferase family 5A, member 1
increases expression
EXP
GW 4064 results in increased expression of SULT1A1 mRNA
CTD
PMID:26655953
NCBI chr 8:123,869,582...123,885,170
Ensembl chr 8:123,866,931...123,885,054
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Sumo3
small ubiquitin-like modifier 3
multiple interactions
EXP
GW 4064 promotes the reaction [NR1H4 protein binds to SUMO3 gene]
CTD
PMID:20091679
NCBI chr10:77,441,931...77,454,165
Ensembl chr10:77,441,931...77,454,165
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Sun3
Sad1 and UNC84 domain containing 3
increases expression
EXP
GW 4064 results in increased expression of SUN3 mRNA
CTD
PMID:26655953
NCBI chr11:8,962,704...8,998,991
Ensembl chr11:8,966,054...8,998,991
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Susd3
sushi domain containing 3
increases expression
EXP
GW 4064 results in increased expression of SUSD3 mRNA
CTD
PMID:26655953
NCBI chr13:49,378,993...49,402,197
Ensembl chr13:49,384,166...49,402,182
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Syna
syncytin a
increases expression
EXP
GW 4064 results in increased expression of SYNA mRNA
CTD
PMID:26655953
NCBI chr 5:134,586,108...134,605,891
Ensembl chr 5:134,587,000...134,589,025
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Synm
synemin, intermediate filament protein
increases expression
EXP
GW 4064 results in increased expression of SYNM mRNA
CTD
PMID:26655953
NCBI chr 7:67,379,909...67,409,490
Ensembl chr 7:67,379,908...67,409,490
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Syt9
synaptotagmin IX
increases expression
EXP
GW 4064 results in increased expression of SYT9 mRNA
CTD
PMID:26655953
NCBI chr 7:106,969,929...107,147,863
Ensembl chr 7:106,969,935...107,147,863
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Sytl3
synaptotagmin-like 3
increases expression
EXP
GW 4064 results in increased expression of SYTL3 mRNA
CTD
PMID:26655953
NCBI chr17:6,925,633...7,005,449
Ensembl chr17:6,926,492...7,005,443
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Tac1
tachykinin 1
increases expression
EXP
GW 4064 results in increased expression of TAC1 mRNA
CTD
PMID:26655953
NCBI chr 6:7,555,061...7,562,978
Ensembl chr 6:7,554,879...7,565,834
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Tbpl2
TATA box binding protein like 2
decreases expression
EXP
GW 4064 results in decreased expression of TBPL2 mRNA
CTD
PMID:26655953
NCBI chr 2:23,961,378...23,986,607
Ensembl chr 2:23,961,733...23,986,607
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Tbx3
T-box 3
increases expression
ISO
GW 4064 results in increased expression of TBX3 mRNA
CTD
PMID:31437187
NCBI chr 5:119,808,600...119,822,789
Ensembl chr 5:119,808,734...119,822,789
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Tcam1
testicular cell adhesion molecule 1
increases expression
EXP
GW 4064 results in increased expression of TCAM1 mRNA
CTD
PMID:26655953
NCBI chr11:106,163,856...106,179,563
Ensembl chr11:106,167,498...106,179,571
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Tecr
trans-2,3-enoyl-CoA reductase
multiple interactions
ISO
[GW 4064 co-treated with Oleic Acid] results in decreased expression of TECR mRNA
CTD
PMID:30611723
NCBI chr 8:84,298,327...84,321,120
Ensembl chr 8:84,298,327...84,334,600
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Teddm1b
transmembrane epididymal protein 1B
increases expression
EXP
GW 4064 results in increased expression of TEDDM1 mRNA
CTD
PMID:26655953
NCBI chr 1:153,750,089...153,752,622
Ensembl chr 1:153,750,091...153,752,617
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Tfap2e
transcription factor AP-2, epsilon
multiple interactions
EXP
GW 4064 promotes the reaction [NR1H4 protein binds to TFAP2E gene]
CTD
PMID:20091679
NCBI chr 4:126,609,796...126,630,062
Ensembl chr 4:126,609,799...126,630,033
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Tgfb3
transforming growth factor, beta 3
increases expression
ISO
GW 4064 results in increased expression of TGFB3 mRNA
CTD
PMID:31437187
NCBI chr12:86,103,517...86,125,815
Ensembl chr12:86,103,519...86,125,815
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Tgfbi
transforming growth factor, beta induced
increases expression
EXP
GW 4064 results in increased expression of TGFBI mRNA
CTD
PMID:26655953
NCBI chr13:56,757,399...56,787,172
Ensembl chr13:56,757,336...56,787,375
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Tgtp2
T cell specific GTPase 2
decreases expression
EXP
GW 4064 results in decreased expression of TGTP2 mRNA
CTD
PMID:26655953
NCBI chr11:48,948,023...48,955,039
Ensembl chr11:48,948,021...48,955,033
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Tkfc
triokinase, FMN cyclase
increases expression
EXP
GW 4064 results in increased expression of TKFC mRNA
CTD
PMID:26655953
NCBI chr19:10,565,153...10,583,257
Ensembl chr19:10,565,155...10,583,018
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Tlr3
toll-like receptor 3
multiple interactions
EXP
GW 4064 promotes the reaction [NR1H4 protein binds to TLR3 gene]
CTD
PMID:20091679
NCBI chr 8:45,848,702...45,864,112
Ensembl chr 8:45,848,702...45,864,117
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Tm4sf4
transmembrane 4 superfamily member 4
increases expression
EXP
GW 4064 results in increased expression of TM4SF4 mRNA
CTD
PMID:26655953
NCBI chr 3:57,332,831...57,349,098
Ensembl chr 3:57,332,735...57,349,098
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Tm6sf2
transmembrane 6 superfamily member 2
increases expression
EXP
GW 4064 results in increased expression of TM6SF2 mRNA
CTD
PMID:26655953
NCBI chr 8:70,525,574...70,532,716
Ensembl chr 8:70,525,574...70,532,716
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Tmed6
transmembrane p24 trafficking protein 6
decreases expression
EXP
GW 4064 results in decreased expression of TMED6 mRNA
CTD
PMID:26655953
NCBI chr 8:107,788,116...107,792,276
Ensembl chr 8:107,788,108...107,792,276
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Tmem174
transmembrane protein 174
increases expression
EXP
GW 4064 results in increased expression of TMEM174 mRNA
CTD
PMID:26655953
NCBI chr13:98,771,486...98,773,918
Ensembl chr13:98,771,486...98,773,918
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Tmem179
transmembrane protein 179
increases expression
EXP
GW 4064 results in increased expression of TMEM179 mRNA
CTD
PMID:26655953
NCBI chr12:112,466,618...112,477,594
Ensembl chr12:112,466,623...112,483,181
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Tmt1b
thiol methyltransferase 1B
increases expression
EXP
GW 4064 results in increased expression of TMT1B mRNA
CTD
PMID:26655953
NCBI chr10:128,794,146...128,796,857
Ensembl chr10:128,794,143...128,796,857
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Tnf
tumor necrosis factor
multiple interactions decreases expression
ISO EXP
GW 4064 inhibits the reaction [TNF protein results in increased expression of IL1B mRNA]; GW 4064 inhibits the reaction [TNF protein results in increased expression of NR1H4 mRNA] GW 4064 results in decreased expression of TNF mRNA GW 4064 inhibits the reaction [[triptolide co-treated with TNF protein] results in decreased expression of NR0B2 protein]; GW 4064 inhibits the reaction [[triptolide co-treated with TNF protein] results in increased cleavage of CASP1 protein]; GW 4064 inhibits the reaction [[triptolide co-treated with TNF protein] results in increased cleavage of GSDMD protein]; GW 4064 inhibits the reaction [[triptolide co-treated with TNF protein] results in increased expression of IL1B mRNA]; GW 4064 inhibits the reaction [[triptolide co-treated with TNF protein] results in increased expression of NLRP3 protein]
CTD
PMID:21242261 PMID:23371517 PMID:36328986
NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
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Tnfrsf22
tumor necrosis factor receptor superfamily, member 22
decreases expression
ISO
GW 4064 results in decreased expression of TNFRSF10B mRNA
CTD
PMID:14623915
NCBI chr 7:143,188,540...143,203,412
Ensembl chr 7:143,188,543...143,203,398
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Tnfrsf9
tumor necrosis factor receptor superfamily, member 9
increases expression
EXP
GW 4064 results in increased expression of TNFRSF9 mRNA
CTD
PMID:26655953
NCBI chr 4:151,004,612...151,030,561
Ensembl chr 4:150,999,019...151,030,559
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Tnfsf15
tumor necrosis factor (ligand) superfamily, member 15
increases expression
EXP
GW 4064 results in increased expression of TNFSF15 mRNA
CTD
PMID:26655953
NCBI chr 4:63,642,837...63,663,296
Ensembl chr 4:63,642,840...63,663,350
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Trf
transferrin
increases expression
EXP
GW 4064 results in increased expression of TRF mRNA
CTD
PMID:26655953
NCBI chr 9:103,086,075...103,107,485
Ensembl chr 9:103,081,200...103,107,643
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Trim54
tripartite motif-containing 54
increases expression
EXP
GW 4064 results in increased expression of TRIM54 mRNA
CTD
PMID:26655953
NCBI chr 5:31,273,956...31,294,970
Ensembl chr 5:31,274,056...31,294,974
G
Triml2
tripartite motif family-like 2
decreases expression
EXP
GW 4064 results in decreased expression of TRIML2 mRNA
CTD
PMID:26655953
NCBI chr 8:43,633,500...43,646,921
Ensembl chr 8:43,633,578...43,646,918
G
Trp53
transformation related protein 53
decreases expression
ISO
GW 4064 results in decreased expression of TP53 mRNA; GW 4064 results in decreased expression of TP53 protein
CTD
PMID:28496032
NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699
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Trpc3
transient receptor potential cation channel, subfamily C, member 3
decreases expression
EXP
GW 4064 results in decreased expression of TRPC3 mRNA
CTD
PMID:26655953
NCBI chr 3:36,674,626...36,744,276
Ensembl chr 3:36,674,631...36,744,316
G
Trpm7
transient receptor potential cation channel, subfamily M, member 7
multiple interactions
EXP
GW 4064 promotes the reaction [NR1H4 protein binds to TRPM7 gene]
CTD
PMID:20091679
NCBI chr 2:126,633,478...126,718,181
Ensembl chr 2:126,633,485...126,718,150
G
Tslp
thymic stromal lymphopoietin
decreases expression
EXP
GW 4064 results in decreased expression of TSLP mRNA
CTD
PMID:26655953
NCBI chr18:32,948,436...32,952,852
Ensembl chr18:32,948,436...32,952,850
G
Ttbk1
tau tubulin kinase 1
increases expression
EXP
GW 4064 results in increased expression of TTBK1 mRNA
CTD
PMID:26655953
NCBI chr17:46,751,577...46,798,596
Ensembl chr17:46,753,374...46,798,601
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Ttc36
tetratricopeptide repeat domain 36
increases expression
EXP
GW 4064 results in increased expression of TTC36 mRNA
CTD
PMID:26655953
NCBI chr 9:44,710,697...44,714,248
Ensembl chr 9:44,710,694...44,714,369
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Ttk
Ttk protein kinase
increases expression
ISO
GW 4064 results in increased expression of TTK mRNA
CTD
PMID:31437187
NCBI chr 9:83,716,704...83,754,442
Ensembl chr 9:83,716,742...83,754,442
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Txk
TXK tyrosine kinase
decreases expression
EXP
GW 4064 results in decreased expression of TXK mRNA
CTD
PMID:26655953
NCBI chr 5:72,853,321...72,910,337
Ensembl chr 5:72,853,321...72,910,120
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Ubd
ubiquitin D
increases expression
EXP
GW 4064 results in increased expression of UBD mRNA
CTD
PMID:26655953
NCBI chr17:37,504,783...37,506,992
Ensembl chr17:37,504,783...37,506,986
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Ube2ql1
ubiquitin-conjugating enzyme E2Q family-like 1
decreases expression
EXP
GW 4064 results in decreased expression of UBE2QL1 mRNA
CTD
PMID:26655953
NCBI chr13:69,850,951...69,888,016
Ensembl chr13:69,850,951...69,888,008
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Ugt1a2
UDP glucuronosyltransferase 1 family, polypeptide A2
multiple interactions
ISO
[GW 4064 results in increased activity of NR1H4 protein] which results in increased expression of UGT1A3 mRNA
CTD
PMID:20189675
NCBI chr 1:88,128,333...88,147,724
Ensembl chr 1:88,128,323...88,146,719
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Unc13c
unc-13 homolog C
increases expression
EXP
GW 4064 results in increased expression of UNC13C mRNA
CTD
PMID:26655953
NCBI chr 9:73,386,704...73,915,421
Ensembl chr 9:73,386,704...73,876,248
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Unc5cl
unc-5 family C-terminal like
increases expression
EXP
GW 4064 results in increased expression of UNC5CL mRNA
CTD
PMID:26655953
NCBI chr17:48,761,155...48,846,737
Ensembl chr17:48,761,929...48,846,742
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Uroc1
urocanase domain containing 1
increases expression
EXP
GW 4064 results in increased expression of UROC1 mRNA
CTD
PMID:26655953
NCBI chr 6:90,310,221...90,341,533
Ensembl chr 6:90,310,266...90,341,533
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Usp18
ubiquitin specific peptidase 18
decreases expression
EXP
GW 4064 results in decreased expression of USP18 mRNA
CTD
PMID:26655953
NCBI chr 6:121,222,865...121,247,876
Ensembl chr 6:121,222,865...121,247,876
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Vcam1
vascular cell adhesion molecule 1
increases expression
ISO
GW 4064 results in increased expression of VCAM1 mRNA
CTD
PMID:16582018
NCBI chr 3:115,903,669...115,923,337
Ensembl chr 3:115,903,598...115,923,337
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Vdac1
voltage-dependent anion channel 1
multiple interactions
EXP
GW 4064 inhibits the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of VDAC1 mRNA]
CTD
PMID:28223344
NCBI chr11:52,251,905...52,280,224
Ensembl chr11:52,251,687...52,280,224
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Vegfd
vascular endothelial growth factor D
decreases expression
EXP
GW 4064 results in decreased expression of VEGFD mRNA
CTD
PMID:26655953
NCBI chr X:163,156,282...163,185,643
Ensembl chr X:163,156,374...163,185,646
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Vipr1
vasoactive intestinal peptide receptor 1
multiple interactions increases expression
ISO
alitretinoin inhibits the reaction [GW 4064 results in increased expression of VIPR1]
CTD
PMID:16037943
NCBI chr 9:121,471,782...121,502,020
Ensembl chr 9:121,471,782...121,502,020
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Vkorc1
vitamin K epoxide reductase complex, subunit 1
multiple interactions
EXP
GW 4064 promotes the reaction [NR1H4 protein binds to VKORC1 gene]
CTD
PMID:20091679
NCBI chr 7:127,492,235...127,494,833
Ensembl chr 7:127,485,399...127,494,626 Ensembl chr 7:127,485,399...127,494,626
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Vmn1r231
vomeronasal 1 receptor 231
increases expression
EXP
GW 4064 results in increased expression of VMN1R231 mRNA
CTD
PMID:26655953
NCBI chr17:21,109,978...21,110,913
Ensembl chr17:21,109,445...21,125,353
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Vmn1r26
vomeronasal 1 receptor 26
decreases expression
EXP
GW 4064 results in decreased expression of VMN1R26 mRNA
CTD
PMID:26655953
NCBI chr 6:57,985,168...57,986,187
Ensembl chr 6:57,981,919...57,992,144
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Vnn1
vanin 1
increases expression
EXP
GW 4064 results in increased expression of VNN1 mRNA
CTD
PMID:26655953
NCBI chr10:23,770,586...23,781,242
Ensembl chr10:23,770,586...23,781,241
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Vsig4
V-set and immunoglobulin domain containing 4
decreases expression
EXP
GW 4064 results in decreased expression of VSIG4 mRNA
CTD
PMID:26655953
NCBI chr X:95,290,807...95,337,044
Ensembl chr X:95,290,809...95,337,044
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Vwce
von Willebrand factor C and EGF domains
increases expression
EXP
GW 4064 results in increased expression of VWCE mRNA
CTD
PMID:26655953
NCBI chr19:10,611,582...10,643,577
Ensembl chr19:10,611,577...10,643,577
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Wdr7
WD repeat domain 7
decreases expression
EXP
GW 4064 results in decreased expression of WDR7 mRNA
CTD
PMID:26655953
NCBI chr18:63,841,731...64,122,831
Ensembl chr18:63,841,756...64,122,847
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Wdr86
WD repeat domain 86
decreases expression
EXP
GW 4064 results in decreased expression of WDR86 mRNA
CTD
PMID:26655953
NCBI chr 5:24,901,898...24,935,696
Ensembl chr 5:24,916,736...24,935,725
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Wee1
WEE 1 homolog 1 (S. pombe)
increases expression
ISO
GW 4064 results in increased expression of WEE1 mRNA
CTD
PMID:31437187
NCBI chr 7:109,721,266...109,742,506
Ensembl chr 7:109,721,253...109,742,493
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Wscd2
WSC domain containing 2
decreases expression
EXP
GW 4064 results in decreased expression of WSCD2 mRNA
CTD
PMID:26655953
NCBI chr 5:113,636,976...113,727,786
Ensembl chr 5:113,638,199...113,727,786
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Xpnpep2
X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound
increases expression
EXP
GW 4064 results in increased expression of XPNPEP2 mRNA
CTD
PMID:26655953
NCBI chr X:47,195,790...47,225,859
Ensembl chr X:47,197,602...47,225,858
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Zbtb16
zinc finger and BTB domain containing 16
decreases expression multiple interactions
EXP
GW 4064 results in decreased expression of ZBTB16 mRNA bisphenol A inhibits the reaction [GW 4064 results in decreased expression of ZBTB16 mRNA]; NR1H4 gene mutant form inhibits the reaction [GW 4064 results in decreased expression of ZBTB16 mRNA]; Stigmasterol inhibits the reaction [GW 4064 results in decreased expression of ZBTB16 mRNA]
CTD
PMID:26655953 PMID:30245210
NCBI chr 9:48,563,097...48,747,525
Ensembl chr 9:48,565,597...48,747,522
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Zdhhc19
zinc finger, DHHC domain containing 19
increases expression
EXP
GW 4064 results in increased expression of ZDHHC19 mRNA
CTD
PMID:26655953
NCBI chr16:32,315,059...32,326,032
Ensembl chr16:32,315,083...32,380,784
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Zfp626
zinc finger protein 626
decreases expression
EXP
GW 4064 results in decreased expression of ZFP626 mRNA
CTD
PMID:26655953
NCBI chr 7:27,504,165...27,522,348
Ensembl chr 7:27,506,621...27,522,341
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