Fbxw15 (F-box and WD-40 domain protein 15) - Rat Genome Database
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Gene: Fbxw15 (F-box and WD-40 domain protein 15) Mus musculus
Analyze
No known orthologs.
Symbol: Fbxw15
Name: F-box and WD-40 domain protein 15
RGD ID: 1614022
MGI Page MGI
Description: Localizes to endoplasmic reticulum. Orthologous to human FBXW12 (F-box and WD repeat domain containing 12); INTERACTS WITH 1,2-dimethylhydrazine; choline; folic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: F-box/WD repeat-containing protein 15; Fbxo12; Fbxo12J; MGC117507
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399109,381,670 - 109,397,330 (-)NCBIGRCm39mm39
GRCm389109,552,602 - 109,568,262 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9109,552,602 - 109,568,262 (-)EnsemblGRCm38mm10GRCm38
MGSCv379109,455,116 - 109,470,776 (-)NCBIGRCm37mm9NCBIm37
MGSCv369109,410,017 - 109,425,668 (-)NCBImm8
MGSCv369110,635,310 - 110,651,018 (-)NCBImm8
Celera9109,269,822 - 109,384,700 (-)NCBICelera
Cytogenetic Map9F2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
1. RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:15520277   PMID:16141072   PMID:16141073   PMID:18094359   PMID:23319590  


Genomics

Position Markers
D9Mit277  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm389109,558,488 - 109,558,657UniSTSGRCm38
MGSCv379109,461,002 - 109,461,171UniSTSGRCm37
Celera9109,275,710 - 109,275,881UniSTS
Cytogenetic Map9F2UniSTS
cM Map961.0UniSTS
Whitehead Genetic960.1UniSTS
Whitehead/MRC_RH91117.57UniSTS
Whitehead_YAC9 UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4141833W10q13_mweight 10 weeks QTL 13 (mouse)Not determined63332429120362868Mouse
4141545Tailaq2_mtail length adjusted QTL 2 (mouse)Not determined63332429120362868Mouse
1357635Splq4_mspleen weight QTL 4 (mouse)Not determined963332429120362868Mouse
1302065El1_mepilepsy 1 (mouse)Not determined975775364114474379Mouse
10054492El7_mepilepsy 7 (mouse)Not determined975775364114474379Mouse
1301407Rapop2_mradiation-induced apoptosis 2 (mouse)Not determined976535936110536130Mouse
1301192Skts6_mskin tumor susceptibility 6 (mouse)Not determined978640645112640755Mouse
10401247Bglu14_mblood glucose level 14 (mouse)Not determined979397810113397888Mouse
1301732Char1_mP. chabaudi malaria resistance QTL 1 (mouse)Not determined981798268115798392Mouse
1300884Sluc11_msusceptibility to lung cancer 11 (mouse)Not determined982910333116910428Mouse
1357461Idd2_minsulin dependent diabetes susceptibility 2 (mouse)Not determined982910333116910428Mouse
10766454Char10_mP. chabaudi malaria resistance QTL 10 (mouse)982910333116910428Mouse
1301487Nociq1_mnociceptive sensitivity inflammatory QTL 1 (mouse)Not determined984528818118528921Mouse
1300549Bbaa17_mB. burgdorferi-associated arthritis 17 (mouse)Not determined986230401120230530Mouse
1302103Dob2_mdietary obesity 2 (mouse)Not determined986239845120289624Mouse
11251716Siim2_mstress induced immobility 2 (mouse)986748483120748483Mouse
12880422V25Dq6_mvitamin D inactive form serum level QTL 6 (mouse)987800000121800000Mouse
10412242Alpq8_malcohol preference QTL 8 (mouse)Not determined989284925123284925Mouse
1301649Psl1_mpromotion susceptibility QTL 1 (mouse)Not determined989412277123412396Mouse
18182932Metl3_mmetabolite locus 3, N-acetylglutamate (mouse)989563342123563342Mouse
1357657Pymr_mPlasmodium yoelli malaria resistance (mouse)Not determined989977005118938021Mouse
12910770Splic1_mspleen iron content 1 (mouse)991413879124595110Mouse
12910772Lvic6_mliver iron content 6 (mouse)991413879124595110Mouse
12910773Splic3_mspleen iron content 3 (mouse)991413879124595110Mouse
1558767Skmw11_mskeletal muscle weight 11 (mouse)Not determined991641084124595110Mouse
13463474Hbbcq5_mhemoglobin concentration QTL 5 (mouse)991641084124595110Mouse
13463475Hctq7_mhematocrit QTL 7 (mouse)991641084124595110Mouse
13463477Rbc9_mred blood cell count 9 (mouse)991641084124595110Mouse
13463478Mchq18_mmean corpuscular hemoglobin QTL 18 (mouse)991641084124595110Mouse
13463480Mchcq2_mmean corpuscular hemoglobin concentration QTL 2 (mouse)991641084124595110Mouse
12904937Edlmmq9_mextensor digitorum longus muscle mass QTL 9 (mouse)991683173124595110Mouse
12904947Tammq7_mtibialis anterior muscle mass QTL 7 (mouse)991683173124595110Mouse
12904961Gmmq7_mgastrocnemius muscle mass QTL 7 (mouse)991683173124595110Mouse
1302001Bdln5_mbody length 5 (mouse)Not determined993762590124595110Mouse
1301484Bwq6_mbody weight (mouse)Not determined993762590124595110Mouse
14746992Manh67_mmandible shape 67 (mouse)994036768124595110Mouse
11081166Psl5_mpromotion susceptibility QTL 5 (mouse)994981301112872929Mouse
11537364Cnes5_mC. neoformans susceptibility locus 5 (mouse)996917590124595110Mouse
1301297Lcho1_mliver cholesterol 1 (mouse)Not determined9101060861124595110Mouse
1357627Tgq2_mtriglyceride QTL 2 (mouse)Not determined9102000187124595110Mouse
1357648Obq18_mobesity QTL 18 (mouse)Not determined9102000187124595110Mouse
1301789Pbwg4_mpostnatal body weight growth 4 (mouse)Not determined9103289445124595110Mouse
10412290Pvacm1l_mplasma vascular cell adhesion molecule 1 levels (mouse)Not determined9103289445124595110Mouse
12879896Berr3_mberghei resistance locus 3 (mouse)9103289445124595110Mouse
13515058Adip20d_madiposity 20d (mouse)9108915010118915010Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:139
Count of miRNA genes:133
Interacting mature miRNAs:139
Transcripts:ENSMUST00000056745
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000056745   ⟹   ENSMUSP00000058175
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9109,552,602 - 109,568,262 (-)Ensembl
RefSeq Acc Id: ENSMUST00000198112   ⟹   ENSMUSP00000142894
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9109,557,159 - 109,568,248 (-)Ensembl
RefSeq Acc Id: ENSMUST00000198397   ⟹   ENSMUSP00000143385
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9109,552,609 - 109,568,250 (-)Ensembl
RefSeq Acc Id: NM_199036   ⟹   NP_950201
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399109,381,670 - 109,397,330 (-)NCBI
GRCm389109,552,602 - 109,568,262 (-)NCBI
MGSCv379109,455,116 - 109,470,776 (-)RGD
Celera9109,269,822 - 109,285,515 (-)NCBI
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006512169   ⟹   XP_006512232
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399109,381,677 - 109,397,312 (-)NCBI
GRCm389109,552,609 - 109,568,244 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011242979   ⟹   XP_011241281
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399109,387,295 - 109,397,312 (-)NCBI
GRCm389109,558,227 - 109,568,244 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_950201   ⟸   NM_199036
- UniProtKB: L7N1X6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006512232   ⟸   XM_006512169
- Peptide Label: isoform X1
- UniProtKB: L7N1X6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011241281   ⟸   XM_011242979
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSMUSP00000142894   ⟸   ENSMUST00000198112
RefSeq Acc Id: ENSMUSP00000143385   ⟸   ENSMUST00000198397
RefSeq Acc Id: ENSMUSP00000058175   ⟸   ENSMUST00000056745
Protein Domains
F-box


Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3505701 AgrOrtholog
Ensembl Genes ENSMUSG00000074060 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000058175 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000142894 UniProtKB/TrEMBL
  ENSMUSP00000143385 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000056745 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000198112 UniProtKB/TrEMBL
  ENSMUST00000198397 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 2.130.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro F-box-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  F-box_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:382105 UniProtKB/Swiss-Prot
MGD MGI:3505701 ENTREZGENE
NCBI Gene 382105 ENTREZGENE
Pfam F-box-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Fbxw15 PhenoGen
PROSITE FBOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART FBOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50978 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF81383 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Mm.335468 ENTREZGENE
UniProt A0A0G2JET0_MOUSE UniProtKB/TrEMBL
  FBW15_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q4FZL6 UniProtKB/Swiss-Prot
  Q4PLJ2 UniProtKB/Swiss-Prot
  Q8BI39 UniProtKB/Swiss-Prot