Kcne4 (potassium voltage-gated channel, Isk-related subfamily, gene 4) - Rat Genome Database

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Gene: Kcne4 (potassium voltage-gated channel, Isk-related subfamily, gene 4) Mus musculus
Analyze
Symbol: Kcne4
Name: potassium voltage-gated channel, Isk-related subfamily, gene 4
RGD ID: 1552068
MGI Page MGI
Description: Predicted to enable potassium channel activity; potassium channel regulator activity; and transmembrane transporter binding activity. Predicted to contribute to delayed rectifier potassium channel activity and voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization. Predicted to be involved in several processes, including ion transmembrane transport; regulation of heart rate by cardiac conduction; and regulation of ion transmembrane transport. Predicted to act upstream of or within potassium ion transmembrane transport and regulation of ion transmembrane transport. Predicted to be located in apical plasma membrane. Predicted to be part of voltage-gated potassium channel complex. Is expressed in heart and heart ventricle. Orthologous to human KCNE4 (potassium voltage-gated channel subfamily E regulatory subunit 4); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; 4-hydroxyphenyl retinamide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AW487937; Mi; minimum potassium ion channel-related peptide 3; minK-related peptide 3; MiRP3; potassium channel subunit beta MiRP3; potassium voltage-gated channel subfamily E member 4
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39178,794,628 - 78,797,749 (+)NCBIGRCm39mm39
GRCm39 Ensembl178,794,475 - 78,797,745 (+)Ensembl
GRCm38178,816,911 - 78,820,032 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl178,816,758 - 78,820,028 (+)EnsemblGRCm38mm10GRCm38
MGSCv37178,813,524 - 78,816,600 (+)NCBIGRCm37mm9NCBIm37
MGSCv36178,695,973 - 78,699,049 (+)NCBImm8
MGSCv36179,687,642 - 79,690,718 (+)NCBImm8
Cytogenetic Map1C4NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

References

Additional References at PubMed
PMID:8889548   PMID:9468318   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11700028   PMID:12477932   PMID:12944270   PMID:15489334   PMID:15707997   PMID:16141072  
PMID:16141073   PMID:16985003   PMID:19773357   PMID:21873635   PMID:26399785   PMID:27710966   PMID:27802162   PMID:29844497   PMID:30758982   PMID:30969795  


Genomics

Comparative Map Data
Kcne4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39178,794,628 - 78,797,749 (+)NCBIGRCm39mm39
GRCm39 Ensembl178,794,475 - 78,797,745 (+)Ensembl
GRCm38178,816,911 - 78,820,032 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl178,816,758 - 78,820,028 (+)EnsemblGRCm38mm10GRCm38
MGSCv37178,813,524 - 78,816,600 (+)NCBIGRCm37mm9NCBIm37
MGSCv36178,695,973 - 78,699,049 (+)NCBImm8
MGSCv36179,687,642 - 79,690,718 (+)NCBImm8
Cytogenetic Map1C4NCBI
KCNE4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2223,051,814 - 223,198,399 (+)EnsemblGRCh38hg38GRCh38
GRCh382223,052,190 - 223,055,637 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372223,916,908 - 223,920,355 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362223,625,106 - 223,628,599 (+)NCBINCBI36hg18NCBI36
Build 342223,742,431 - 223,744,133NCBI
Celera2217,682,314 - 217,685,808 (+)NCBI
Cytogenetic Map2q36.1NCBI
HuRef2215,768,183 - 215,771,892 (+)NCBIHuRef
CHM1_12223,923,002 - 223,926,710 (+)NCBICHM1_1
Kcne4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2980,243,429 - 80,251,533 (+)NCBI
Rnor_6.0 Ensembl984,689,150 - 84,690,338 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0984,688,873 - 84,693,066 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0984,440,098 - 84,448,108 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4978,200,904 - 78,202,092 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1978,384,322 - 78,385,511 (+)NCBI
Celera977,752,308 - 77,753,496 (+)NCBICelera
Cytogenetic Map9q34NCBI
Kcne4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545310,822,977 - 10,826,191 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545310,822,977 - 10,826,191 (-)NCBIChiLan1.0ChiLan1.0
KCNE4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12B228,869,393 - 228,873,101 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B228,869,393 - 228,873,101 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02B110,291,194 - 110,294,996 (+)NCBIMhudiblu_PPA_v0panPan3
KCNE4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13728,994,797 - 28,998,596 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3728,996,105 - 28,996,990 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3729,831,026 - 29,834,649 (+)NCBI
ROS_Cfam_1.03729,020,674 - 29,024,293 (+)NCBI
UMICH_Zoey_3.13728,930,228 - 28,933,850 (+)NCBI
UNSW_CanFamBas_1.03728,864,748 - 28,868,366 (+)NCBI
UU_Cfam_GSD_1.03728,875,316 - 28,878,940 (+)NCBI
Kcne4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303178,596,335 - 178,599,723 (+)NCBI
SpeTri2.0NW_0049365694,939,477 - 4,942,096 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNE4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15124,912,405 - 124,915,780 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115124,910,708 - 124,915,787 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215138,615,216 - 138,619,085 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KCNE4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110108,970,868 - 108,973,080 (+)NCBI
Vero_WHO_p1.0NW_02366604090,393,360 - 90,397,358 (-)NCBI
Kcne4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248232,239,132 - 2,244,758 (-)NCBI

Position Markers
AW487937  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38178,819,781 - 78,819,895UniSTSGRCm38
MGSCv37178,816,356 - 78,816,470UniSTSGRCm37
Cytogenetic Map1C4UniSTS
Whitehead/MRC_RH11143.27UniSTS
UniSTS:234160  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38178,819,822 - 78,820,032UniSTSGRCm38
MGSCv37178,816,397 - 78,816,607UniSTSGRCm37
Cytogenetic Map1C4UniSTS
Kcne4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38178,850,862 - 78,851,163UniSTSGRCm38
MGSCv37178,847,437 - 78,847,738UniSTSGRCm37
Cytogenetic Map1C4UniSTS
cM Map1 UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13824984Twq5_mtestis weight QTL 5 (mouse)13000000185000000Mouse
1357753Kidq2_mkidney weight QTL 2 (mouse)Not determined134721057150318120Mouse
1357488Splq3_mspleen weight QTL 3 (mouse)Not determined134721057150318120Mouse
1558860W10q7_mweight 10 weeks QTL 7 (mouse)Not determined134721057150318120Mouse
1357721Sle17_msystematic lupus erythematosus susceptibility 17 (mouse)Not determined139093727126517573Mouse
1301722Cia9_mcollagen induced arthritis QTL 9 (mouse)Not determined145744740189571420Mouse
1301670Ssta1_msusceptibility to Salmonella typhimurium antigens 1 (mouse)Not determined14590759679907723Mouse
1301225Sle7_msystematic lupus erythematosus susceptibility 7 (mouse)Not determined14681553180815680Mouse
1301616Yaa2_mY-linked autoimmune acceleration 2 (mouse)Not determined14681553180815680Mouse
1558905Gct7_mgranulosa cell tumorigenesis 7 (mouse)Not determined14731073581310854Mouse
1558822Vas1_mautoimmune vasitis resistance 1 (mouse)Not determined14884984782850051Mouse
1301211Bbaa11_mB.burgdorferi-associated arthritis 11 (mouse)Not determined14884984782850051Mouse
1301430Cdcs2_mcytokine deficiency colitis susceptibility 2 (mouse)Not determined14885318682853326Mouse
10043965Obq24_mobesity QTL 24 (mouse)Not determined15085105784851057Mouse
4141305Tgq9_mtriglyceride QTL 9 (mouse)Not determined5138244685382446Mouse
4142291Aec2_mautoimmune exocrinopathy 2 (mouse)Not determined52418578182423027Mouse
1357741Nidd5k_mNidd5 on KK-A<y> (mouse)Not determined15593578989935898Mouse
1357505Vtbt1_mvertebral trabecular bone trait 1 (mouse)Not determined15622705590227201Mouse
4142467Wbcq1_mwhite blood cell quantitative locus 1 (mouse)Not determined15622705590227201Mouse
1301933Insq6_minsulin QTL 6 (mouse)Not determined15668776390687918Mouse
1558717Ses1a_msalmonella enteritidis susceptibility 1a (mouse)Not determined15668776390687918Mouse
14746998Mancz1_mmandible centroid size 1 (mouse)15790219291902192Mouse
14747009Manh49_mmandible shape 49 (mouse)15790219291902192Mouse
1300746Skl1_mskeletal size (tail length) 1 (mouse)Not determined15795281891952921Mouse
1357679Egrm1_mearly growth rate, maternal effect 1 (mouse)Not determined15795281891952921Mouse
1301162Skull1_mskull morphology 1 (mouse)Not determined15795281891952921Mouse
1301444Alcw5_malcohol withdrawal 5 (mouse)Not determined15857254792572799Mouse
1301667Lxw5_mlupus BXSB x NZW 5 (mouse)Not determined15857254792572799Mouse
1301748Abbp1_mA/J and C57BL/6 blood pressure 1 (mouse)Not determined162907596120601949Mouse
10412185Hcs9_mhepatocarcinogenesis susceptibility 9 (mouse)Not determined163815531189571420Mouse
1300841Ssial1_msusceptibility to sialadenitis 1 (mouse)Not determined163880843153681816Mouse
1302119Cia15_mcollagen induced arthritis 15 (mouse)Not determined16584984788568379Mouse
27095918Ulnl1_mulna length 1, 5 week (mouse)167300000129800000Mouse
4141625Emo4_memotionality 4 (mouse)Not determined6803218686307305Mouse
1302146Cocrb1_mcocaine related behavior 1 (mouse)Not determined170205811104211835Mouse
1300976Bmd19_mbone mineral density 19 (mouse)Not determined173227055108910684Mouse
4142394Mssq1_mmandible size and shape QTL 1 (mouse)Not determined73687970107688108Mouse
1301304Hrq3_mheart rate quantitative locus 3 (mouse)Not determined173687970107688108Mouse
1300989Lrdg1_mlight induced retinal degeneration 1 (mouse)Not determined173716016147249632Mouse
14697705Stsl3b_mSalmonella typhimurium susceptibility locus 3b (mouse)17410000081800000Mouse
4141914Gcsfis_mG-CSF induced splenomegaly (mouse)Not determined74477076148839837Mouse
1357847Jckm2_mjuvenile cystic kidney modifier 2 (mouse)Not determined174952818133363199Mouse
1300821Lore1_mloss of righting induced by ethanol 1 (mouse)Not determined17557254793013355Mouse
27095931Pglq1_mpelvic girdle length QTL 1, 5 week (mouse)176000000128600000Mouse
27095928Pglq6_mpelvic girdle length QTL 6, 10 week (mouse)176000000148900000Mouse
26884448Sklq1_mskull length QTL 1, 5 week (mouse)176000000181500000Mouse
1558928Mord2_mmodifier of retinal degeneration 2 (mouse)Not determined177146478110608345Mouse
14697706Stsl3a_mSalmonella typhimurium susceptibility locus 3a (mouse)17750000095900000Mouse
14696691Malq1_mmean attack latency QTL 1 (mouse)17800000088000000Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:544
Count of miRNA genes:390
Interacting mature miRNAs:439
Transcripts:ENSMUST00000057262
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000057262   ⟹   ENSMUSP00000055415
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl178,816,758 - 78,820,028 (+)Ensembl
RefSeq Acc Id: ENSMUST00000187432   ⟹   ENSMUSP00000140235
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl178,816,927 - 78,820,028 (+)Ensembl
RefSeq Acc Id: NM_021342   ⟹   NP_067317
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39178,794,628 - 78,797,749 (+)NCBI
GRCm38178,816,911 - 78,820,032 (+)NCBI
MGSCv37178,813,524 - 78,816,600 (+)RGD
cM Map1 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_067317 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAD28091 (Get FASTA)   NCBI Sequence Viewer  
  AAH32920 (Get FASTA)   NCBI Sequence Viewer  
  AAH34849 (Get FASTA)   NCBI Sequence Viewer  
  Q9WTW3 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_067317   ⟸   NM_021342
- UniProtKB: Q9WTW3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000140235   ⟸   ENSMUST00000187432
RefSeq Acc Id: ENSMUSP00000055415   ⟸   ENSMUST00000057262

Promoters
RGD ID:6817962
Promoter ID:MM_KWN:1290
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney
Transcripts:ENSMUST00000113517
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36178,813,061 - 78,813,561 (+)MPROMDB
RGD ID:6874200
Promoter ID:EPDNEW_M551
Type:single initiation site
Name:Kcne4_1
Description:Mus musculus potassium voltage-gated channel, Isk-related subfamily,gene 4 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38178,816,911 - 78,816,971EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1891125 AgrOrtholog
Ensembl Genes ENSMUSG00000047330 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000055415 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000140235 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000057262 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000187432 UniProtKB/TrEMBL
InterPro K_chnl_KCNE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:57814 UniProtKB/Swiss-Prot
MGD MGI:1891125 ENTREZGENE
NCBI Gene 57814 ENTREZGENE
PANTHER PTHR15282 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ISK_Channel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB KCNE4 RGD
PhenoGen Kcne4 PhenoGen
PRINTS KCNECHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A087WQK6_MOUSE UniProtKB/TrEMBL
  KCNE4_MOUSE UniProtKB/Swiss-Prot
  Q8JZQ4_MOUSE UniProtKB/TrEMBL
  Q9WTW3 ENTREZGENE