Rabggta (Rab geranylgeranyl transferase, a subunit) - Rat Genome Database

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Gene: Rabggta (Rab geranylgeranyl transferase, a subunit) Mus musculus
Analyze
Symbol: Rabggta
Name: Rab geranylgeranyl transferase, a subunit
RGD ID: 735604
MGI Page MGI
Description: Enables Rab geranylgeranyltransferase activity. Acts upstream of or within protein geranylgeranylation. Predicted to be located in nucleoplasm. Predicted to be part of Rab-protein geranylgeranyltransferase complex. Predicted to be active in cytoplasm. Used to study Hermansky-Pudlak syndrome. Orthologous to human RABGGTA (Rab geranylgeranyltransferase subunit alpha); INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; 4-hydroxyphenyl retinamide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: geranylgeranyl transferase type II subunit alpha; geranylgeranyl transferase type-2 subunit alpha; gm; gunmetal; rab geranyl-geranyltransferase subunit alpha; rab geranylgeranyltransferase subunit alpha; rab GG transferase alpha; rab GGTase alpha
RGD Orthologs
Human
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391455,953,321 - 55,959,720 (-)NCBIGRCm39mm39
GRCm39 Ensembl1455,952,873 - 55,959,720 (-)Ensembl
GRCm381455,715,864 - 55,722,263 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1455,715,416 - 55,722,263 (-)EnsemblGRCm38mm10GRCm38
MGSCv371456,334,714 - 56,341,013 (-)NCBIGRCm37mm9NCBIm37
MGSCv361454,669,948 - 54,676,247 (-)NCBImm8
Celera1453,520,890 - 53,527,189 (-)NCBICelera
Cytogenetic Map14C3NCBI
cM Map1428.19NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:7544156   PMID:7703484   PMID:8490171   PMID:8833241   PMID:8889548   PMID:9714600   PMID:10193444   PMID:10349636   PMID:10486237   PMID:10737774   PMID:11041359   PMID:11042159  
PMID:11076861   PMID:11266472   PMID:11972527   PMID:12122117   PMID:12445206   PMID:12477932   PMID:12907454   PMID:14610273   PMID:15188402   PMID:15782199   PMID:16141072   PMID:16141073  
PMID:18685105   PMID:18715234   PMID:18799693   PMID:21267068   PMID:21419243   PMID:21677750   PMID:21776414   PMID:21873635   PMID:27626380   PMID:32325033  


Genomics

Comparative Map Data
Rabggta
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391455,953,321 - 55,959,720 (-)NCBIGRCm39mm39
GRCm39 Ensembl1455,952,873 - 55,959,720 (-)Ensembl
GRCm381455,715,864 - 55,722,263 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1455,715,416 - 55,722,263 (-)EnsemblGRCm38mm10GRCm38
MGSCv371456,334,714 - 56,341,013 (-)NCBIGRCm37mm9NCBIm37
MGSCv361454,669,948 - 54,676,247 (-)NCBImm8
Celera1453,520,890 - 53,527,189 (-)NCBICelera
Cytogenetic Map14C3NCBI
cM Map1428.19NCBI
RABGGTA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1424,265,538 - 24,271,611 (-)EnsemblGRCh38hg38GRCh38
GRCh381424,265,538 - 24,271,627 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371424,734,744 - 24,740,833 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361423,804,584 - 23,810,643 (-)NCBINCBI36hg18NCBI36
Build 341423,804,585 - 23,810,643NCBI
Celera144,599,360 - 4,605,419 (-)NCBI
Cytogenetic Map14q12NCBI
HuRef144,849,901 - 4,855,990 (-)NCBIHuRef
CHM1_11424,733,345 - 24,739,434 (-)NCBICHM1_1
Rabggta
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21529,206,328 - 29,213,398 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1529,206,157 - 29,213,348 (-)Ensembl
Rnor_6.01534,393,419 - 34,400,466 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1534,393,233 - 34,400,449 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01538,283,389 - 38,290,429 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41533,862,275 - 33,868,619 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11533,877,146 - 33,883,992 (-)NCBI
Celera1528,783,370 - 28,789,714 (-)NCBICelera
Cytogenetic Map15p13NCBI
RABGGTA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11423,165,254 - 23,171,339 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1423,163,034 - 23,171,311 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0145,041,694 - 5,047,775 (-)NCBIMhudiblu_PPA_v0panPan3
RABGGTA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.184,244,731 - 4,250,836 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl84,244,781 - 4,250,744 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha84,166,409 - 4,172,506 (-)NCBI
ROS_Cfam_1.084,355,507 - 4,361,606 (-)NCBI
UMICH_Zoey_3.184,045,886 - 4,051,978 (-)NCBI
UNSW_CanFamBas_1.084,107,715 - 4,113,807 (-)NCBI
UU_Cfam_GSD_1.084,370,053 - 4,376,415 (-)NCBI
Rabggta
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864036,099,444 - 36,105,342 (-)NCBI
SpeTri2.0NW_004936722283,682 - 289,548 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RABGGTA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl775,021,755 - 75,028,875 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1775,021,716 - 75,028,229 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2780,292,566 - 80,298,870 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RABGGTA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1241,248,637 - 1,254,937 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl241,248,393 - 1,266,254 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603612,933,353 - 12,939,556 (-)NCBIVero_WHO_p1.0
Rabggta
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248208,230,560 - 8,236,843 (+)NCBIHetGla_female_1.0hetGla2


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357589Kdnw2_mkidney weight 2 (mouse)Not determined1420837405121032392Mouse
1357527Epfpq1_mepididymal fat percentage QTL 1 (mouse)Not determined142101238271648361Mouse
14746973Manh76_mmandible shape 76 (mouse)142256526056565260Mouse
4142485Modor2_mmodifier of ocular retardation 2 (mouse)Not determined142492582457942312Mouse
13506929Recrq10_mrecombination rate in male meiosis QTL 10 (mouse)142820000060900000Mouse
10043886Cia49_mcollagen induced arthritis QTL 49 (mouse)Not determined142975953763759676Mouse
1300998Cia17_mcollagen induced arthritis 17 (mouse)Not determined143009779364097924Mouse
1300909Ath13_matherosclerosis 13 (mouse)Not determined143009779364097924Mouse
27226774Tibl15_mtibia length 15, 10 week (mouse)143060000087700000Mouse
27226737Metcl12_mmetatarsal-calcaneal length 12, 10 week (mouse)143350000059200000Mouse
1300625Cosz2_mcocaine seizure 2 (mouse)Not determined143532384068548287Mouse
10043887Cia50_mcollagen induced arthritis QTL 50 (mouse)Not determined143719272871192863Mouse
4142419Tgq26_mtriglyceride QTL 26 (mouse)Not determined4009986274099862Mouse
1301777Bglq15_mbody growth late QTL 15 (mouse)Not determined144272496776725144Mouse
1301424Skull21_mskull morphology 21 (mouse)Not determined144272496776725144Mouse
1300805Mors3_mmodifier of obesity related sterility 3 (mouse)Not determined144279982176799969Mouse
4141400Nilac8_mnicotine induced locomotor activity 8 (mouse)Not determined144282839876828596Mouse
1301091Bbaa21_mB.burgdorferi-associated arthritis 21 (mouse)Not determined144282839876828596Mouse
4141484Hcbip1_mhexachlorobenzene induced porphyria 1 (mouse)Not determined4709779359725144Mouse
1300605El5_mepilepsy 5 (mouse)Not determined144921797683218107Mouse
4142364Pbwg18_mpostnatal body weight growth 18 (mouse)Not determined145204453586044676Mouse
1301489Lbm10_mlean body mass 10 (mouse)Not determined145352385687524089Mouse
12880432Fgf23lq3_mFGF23 serum level QTL 3 (mouse)145370000087700000Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:598
Count of miRNA genes:273
Interacting mature miRNAs:307
Transcripts:ENSMUST00000062861, ENSMUST00000163889, ENSMUST00000169237
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001360387 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001360388 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_019519 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_153435 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF127654 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF127655 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF127656 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF127657 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF127658 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF127659 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF127660 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF127661 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF127662 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK002625 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK146917 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK181036 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC012214 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY150143 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CD776583 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466535 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CT025679 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CX213914 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000062861   ⟹   ENSMUSP00000061498
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1455,953,334 - 55,959,633 (-)Ensembl
GRCm38.p6 Ensembl1455,715,877 - 55,722,176 (-)Ensembl
RefSeq Acc Id: ENSMUST00000163889   ⟹   ENSMUSP00000128668
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1455,953,782 - 55,959,720 (-)Ensembl
GRCm38.p6 Ensembl1455,716,325 - 55,722,263 (-)Ensembl
RefSeq Acc Id: ENSMUST00000169237   ⟹   ENSMUSP00000133032
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1455,953,334 - 55,959,633 (-)Ensembl
GRCm38.p6 Ensembl1455,715,877 - 55,722,176 (-)Ensembl
RefSeq Acc Id: ENSMUST00000226209
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1455,955,012 - 55,956,603 (-)Ensembl
GRCm38.p6 Ensembl1455,717,555 - 55,719,146 (-)Ensembl
RefSeq Acc Id: ENSMUST00000227061   ⟹   ENSMUSP00000154725
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1455,952,873 - 55,959,659 (-)Ensembl
GRCm38.p6 Ensembl1455,715,416 - 55,722,202 (-)Ensembl
RefSeq Acc Id: ENSMUST00000227132
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1455,958,605 - 55,959,714 (-)Ensembl
GRCm38.p6 Ensembl1455,721,148 - 55,722,257 (-)Ensembl
RefSeq Acc Id: ENSMUST00000227617
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1455,956,608 - 55,957,590 (-)Ensembl
GRCm38.p6 Ensembl1455,719,151 - 55,720,133 (-)Ensembl
RefSeq Acc Id: ENSMUST00000228604
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1455,953,334 - 55,959,633 (-)Ensembl
GRCm38.p6 Ensembl1455,715,877 - 55,722,176 (-)Ensembl
RefSeq Acc Id: ENSMUST00000228826
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1455,953,334 - 55,959,633 (-)Ensembl
GRCm38.p6 Ensembl1455,715,877 - 55,722,176 (-)Ensembl
RefSeq Acc Id: ENSMUST00000228899
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1455,953,762 - 55,959,638 (-)Ensembl
GRCm38.p6 Ensembl1455,716,305 - 55,722,181 (-)Ensembl
RefSeq Acc Id: NM_001360387   ⟹   NP_001347316
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391455,953,321 - 55,959,720 (-)NCBI
GRCm381455,715,864 - 55,722,263 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001360388   ⟹   NP_001347317
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391455,953,321 - 55,959,659 (-)NCBI
GRCm381455,715,864 - 55,722,202 (-)NCBI
Sequence:
RefSeq Acc Id: NM_019519   ⟹   NP_062392
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391455,953,321 - 55,959,380 (-)NCBI
GRCm381455,715,864 - 55,721,923 (-)NCBI
MGSCv371456,334,714 - 56,341,013 (-)RGD
Celera1453,520,890 - 53,527,189 (-)RGD
cM Map14 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_153435
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391455,953,321 - 55,959,659 (-)NCBI
GRCm381455,715,864 - 55,722,202 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_062392   ⟸   NM_019519
- UniProtKB: Q9JHK4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001347316   ⟸   NM_001360387
RefSeq Acc Id: NP_001347317   ⟸   NM_001360388
RefSeq Acc Id: ENSMUSP00000128668   ⟸   ENSMUST00000163889
RefSeq Acc Id: ENSMUSP00000133032   ⟸   ENSMUST00000169237
RefSeq Acc Id: ENSMUSP00000154725   ⟸   ENSMUST00000227061
RefSeq Acc Id: ENSMUSP00000061498   ⟸   ENSMUST00000062861
Protein Domains
RabGGT_insert

Promoters
RGD ID:8682464
Promoter ID:EPDNEW_M19263
Type:initiation region
Name:Rabggta_1
Description:Mus musculus Rab geranylgeranyl transferase, a subunit , transcriptvariant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381455,722,257 - 55,722,317EPDNEW
RGD ID:6847135
Promoter ID:MM_ACW:16089
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney,   Liver
Transcripts:RABGGTA.ISEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361456,338,806 - 56,340,067 (-)MPROMDB
RGD ID:6825325
Promoter ID:MM_KWN:16985
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4
Transcripts:ENSMUST00000062861,   NM_019519,   UC007UAJ.1,   UC007UAL.1,   UC007UAM.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361456,340,716 - 56,341,216 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1860443 AgrOrtholog
Ensembl Genes ENSMUSG00000040472 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000061498 UniProtKB/TrEMBL
  ENSMUSP00000128668 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000133032 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000154725 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000062861 UniProtKB/TrEMBL
  ENSMUST00000163889 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000169237 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000227061 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000228826 ENTREZGENE
Gene3D-CATH 3.80.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro LRR_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prenyl_trans_a UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RabGGT_asu_insert-dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RabGGT_asu_insert-domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RabGGTase_alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:56187 UniProtKB/Swiss-Prot
MGD MGI:1860443 ENTREZGENE
NCBI Gene 56187 ENTREZGENE
PANTHER PTHR11129:SF2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PPTA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RabGGT_insert UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Rabggta PhenoGen
PROSITE PFTA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49594 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A2K6EDL0_MOUSE UniProtKB/TrEMBL
  PGTA_MOUSE UniProtKB/Swiss-Prot
  Q3UIH7_MOUSE UniProtKB/TrEMBL
  Q921J9_MOUSE UniProtKB/TrEMBL
  Q9JHK4 ENTREZGENE
UniProt Secondary Q9JLX2 UniProtKB/Swiss-Prot