Chrna7 (cholinergic receptor, nicotinic, alpha polypeptide 7) - Rat Genome Database

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Gene: Chrna7 (cholinergic receptor, nicotinic, alpha polypeptide 7) Mus musculus
Analyze
Symbol: Chrna7
Name: cholinergic receptor, nicotinic, alpha polypeptide 7
RGD ID: 10357
MGI Page MGI
Description: Enables acetylcholine-gated cation-selective channel activity. Involved in several processes, including plasma membrane bounded cell projection organization; positive regulation of cell communication; and regulation of protein metabolic process. Acts upstream of or within several processes, including behavioral response to ethanol; learning or memory; and negative regulation of cytokine production. Located in apical plasma membrane; axolemma; and external side of plasma membrane. Part of acetylcholine-gated channel complex. Is active in cholinergic synapse. Is integral component of postsynaptic specialization membrane and integral component of presynaptic membrane. Is expressed in several structures, including adrenal gland; alimentary system; nervous system; retina; and thymus. Used to study schizophrenia. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to several human genes including CHRFAM7A (CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Ac; acetylcholine receptor alpha 7 neural; Acra7; al; alpha7; alpha7 nicotinic receptor; alpha7-nAChR; nAchR; neuronal acetylcholine receptor subunit alpha-7
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39762,748,440 - 62,862,274 (-)NCBIGRCm39mm39
GRCm39 Ensembl762,748,440 - 62,862,317 (-)Ensembl
GRCm38763,098,692 - 63,212,526 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl763,098,692 - 63,212,569 (-)EnsemblGRCm38mm10GRCm38
MGSCv37770,243,578 - 70,357,412 (-)NCBIGRCm37mm9NCBIm37
MGSCv36762,977,642 - 63,091,468 (-)NCBImm8
Celera760,542,827 - 60,660,378 (-)NCBICelera
Cytogenetic Map7CNCBI
cM Map734.47NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-beta-thujone  (ISO)
(+)-Nornicotine  (ISO)
(-)-cotinine  (ISO)
(-)-lobeline  (ISO)
(R)-adrenaline  (ISO)
(S)-nicotine  (EXP,ISO)
1,1-dimethyl-4-phenylpiperazinium iodide  (ISO)
1,2-dichloroethane  (EXP)
13-desmethylspirolide C  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
5-hydroxyindole  (ISO)
6-propyl-2-thiouracil  (ISO)
acetamiprid  (EXP)
acetylcholine  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP)
ammonium chloride  (ISO)
Anabaseine  (ISO)
Anatoxin a  (ISO)
atracurium  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (ISO)
butanal  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
cannabidiol  (ISO)
carbachol  (ISO)
carbon nanotube  (EXP)
chlorpyrifos  (EXP,ISO)
choline  (EXP,ISO)
cisatracurium  (ISO)
cisplatin  (ISO)
Citreoviridin  (EXP)
Cuprizon  (ISO)
cytisine  (ISO)
Desformylflustrabromine  (ISO)
dextran sulfate  (EXP)
Diacetoxyscirpenol  (EXP)
diazinon  (ISO)
dieldrin  (ISO)
dihydro-beta-erythroidine  (ISO)
dinophysistoxin 1  (ISO)
dioxygen  (EXP)
doxorubicin  (ISO)
epibatidine  (ISO)
ethanol  (EXP,ISO)
galanthamine  (EXP)
galanthamine Trifluoroacetic acid  (EXP)
gentamycin  (ISO)
GW 4064  (EXP)
herbicide  (EXP)
imidacloprid  (ISO)
ivermectin  (ISO)
lead diacetate  (ISO)
Licochalcone B  (ISO)
linoleic acid  (ISO)
lovastatin  (ISO)
LY294002  (ISO)
manganese(II) chloride  (EXP)
Mecamylamine  (ISO)
melittin  (ISO)
methyllycaconitine  (EXP,ISO)
Mivacurium  (ISO)
N-butyl-N-(4-hydroxybutyl)nitrosamine  (ISO)
N-nitrosodiethylamine  (ISO)
nickel atom  (ISO)
nicotine  (EXP,ISO)
nicotinic acetylcholine receptor agonist  (ISO)
okadaic acid  (ISO)
ozone  (EXP)
pancuronium  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
parathion-methyl  (ISO)
PCB138  (ISO)
potassium dichromate  (EXP)
propanal  (ISO)
resveratrol  (ISO)
rocuronium  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
spinosad  (ISO)
sterigmatocystin  (ISO)
suramin  (EXP)
testosterone  (ISO)
tetrachloroethene  (ISO)
tetrodotoxin  (ISO)
titanium dioxide  (EXP)
toluene  (ISO)
topiramate  (ISO)
trichloroethene  (ISO)
tubocurarine  (ISO)
urethane  (ISO)
varenicline  (ISO)
vecuronium bromide  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acetylcholine receptor signaling pathway  (ISO)
associative learning  (IGI,IMP)
B cell activation  (IMP)
behavioral response to ethanol  (IMP)
behavioral response to nicotine  (IGI)
calcium ion transport  (ISO)
cation transmembrane transport  (IDA)
cellular calcium ion homeostasis  (ISO)
chemical synaptic transmission  (IBA,IDA)
cognition  (ISO)
dendrite arborization  (IMP)
dendritic spine organization  (IMP)
dopamine biosynthetic process  (ISO)
endocytosis  (IMP)
establishment of localization in cell  (IMP)
excitatory postsynaptic potential  (IDA)
flagellated sperm motility  (IMP)
generation of ovulation cycle rhythm  (IMP)
ion transmembrane transport  (IBA,ISO)
ion transport  (IMP)
learning or memory  (IGI,ISO)
membrane depolarization  (IDA,ISO)
memory  (IMP,ISO)
modulation of chemical synaptic transmission  (IGI)
modulation of excitatory postsynaptic potential  (IDA,IGI)
negative regulation of amyloid-beta formation  (ISO)
negative regulation of ERK1 and ERK2 cascade  (ISO)
negative regulation of inflammatory response  (IMP)
negative regulation of interleukin-1 beta production  (IMP)
negative regulation of interleukin-6 production  (IMP)
negative regulation of protein phosphorylation  (IDA)
negative regulation of tumor necrosis factor production  (IMP,ISO)
nervous system process  (IBA)
neuronal action potential  (ISO)
ovulation cycle  (IMP)
positive regulation of acetylcholine biosynthetic process  (IC)
positive regulation of amyloid-beta formation  (IGI)
positive regulation of angiogenesis  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of CoA-transferase activity  (IGI)
positive regulation of ERK1 and ERK2 cascade  (IDA,IGI,IMP,ISO)
positive regulation of excitatory postsynaptic potential  (IGI)
positive regulation of gene expression  (ISO)
positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure  (IMP)
positive regulation of long-term synaptic potentiation  (IDA,IGI)
positive regulation of MAPK cascade  (ISO)
positive regulation of peptidyl-serine phosphorylation  (IMP)
positive regulation of protein metabolic process  (IGI)
positive regulation of protein phosphorylation  (IDA)
regulation of amyloid fibril formation  (IGI)
regulation of amyloid precursor protein catabolic process  (ISO)
regulation of inflammatory response  (IMP)
regulation of membrane potential  (IBA,IMP,ISO)
regulation of neuron death  (IGI)
regulation of nitric oxide metabolic process  (ISO)
regulation of norepinephrine secretion  (IMP)
regulation of response to drug  (ISO)
regulation of synapse structural plasticity  (IC)
regulation of synaptic transmission, cholinergic  (IC)
regulation of synaptic transmission, dopaminergic  (IMP)
regulation of synaptic vesicle exocytosis  (ISO)
response to acetylcholine  (ISO)
response to amyloid-beta  (IMP)
response to carbamate  (ISO)
response to cold  (IDA)
response to ethanol  (IMP)
response to food  (IMP)
response to hypoxia  (ISO)
response to nicotine  (IGI,IMP,ISO)
sensory processing  (IDA,ISO)
signal transduction  (IBA)
synapse organization  (IGI)
synaptic transmission, cholinergic  (IBA,IMP,ISO)
T cell activation  (IMP)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal abdominal wall morphology  (IAGP)
abnormal airway basal cell differentiation  (IAGP)
abnormal bone structure  (IEA)
abnormal brain interneuron morphology  (IAGP)
abnormal brain morphology  (IAGP)
abnormal cerebral cortex morphology  (IAGP)
abnormal cerebral cortex pyramidal cell morphology  (IAGP)
abnormal craniofacial morphology  (IAGP)
abnormal dorsal root ganglion morphology  (IAGP)
abnormal excitatory postsynaptic potential  (IAGP)
abnormal GABA-mediated receptor currents  (IAGP)
abnormal GABAergic neuron morphology  (IAGP)
abnormal GABAergic neuron physiology  (IAGP)
abnormal interleukin level  (IAGP)
abnormal limb bone morphology  (IAGP)
abnormal myeloblast morphology/development  (IAGP)
abnormal nicotine-mediated receptor currents  (IAGP)
abnormal retina pigment epithelium morphology  (IAGP)
abnormal rostral-caudal axis patterning  (IAGP)
abnormal seizure response to pharmacological agent  (IAGP)
abnormal somatosensory cortex morphology  (IAGP)
abnormal spatial learning  (IAGP)
abnormal spatial working memory  (IAGP)
abnormal suckling behavior  (IAGP)
abnormal tail morphology  (IAGP)
abnormal tumor necrosis factor level  (IAGP)
airway basal cell hyperplasia  (IAGP)
anemia  (IAGP)
asthenozoospermia  (IAGP)
decreased anxiety-related response  (IAGP)
decreased CNS synapse formation  (IAGP)
decreased erythroblast number  (IAGP)
decreased IgG level  (IAGP)
decreased immunoglobulin level  (IAGP)
decreased litter size  (IAGP)
decreased locomotor activity  (IAGP)
decreased neutrophil cell number  (IAGP)
delayed caudal neuropore closure  (IAGP)
dorsal root ganglion hypoplasia  (IAGP)
enhanced coordination  (IAGP)
enlarged liver  (IAGP)
enlarged pancreas  (IAGP)
enlarged salivary gland  (IAGP)
failure of neuromuscular synapse presynaptic differentiation  (IAGP)
flat head  (IAGP)
hunched posture  (IAGP)
hyperactivity  (IAGP)
impaired olfaction  (IAGP)
impaired passive avoidance behavior  (IAGP)
increased circulating cholesterol level  (IEA)
increased circulating HDL cholesterol level  (IEA)
increased lymphocyte cell number  (IAGP)
increased neuron apoptosis  (IAGP)
macrodontia  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
no abnormal phenotype detected  (IAGP)
omphalocele  (IAGP)
perinatal lethality, complete penetrance  (IAGP)
prolonged estrous cycle  (IAGP)
reduced female fertility  (IAGP)
reduced fertility  (IAGP)
short mandible  (IAGP)
spina bifida  (IAGP)
tremors  (IAGP)
References

References - curated
1. Albuquerque EX, etal., Physiol Rev. 2009 Jan;89(1):73-120. doi: 10.1152/physrev.00015.2008.
2. Baird A, etal., BBA Clin. 2016 Jan 8;5:66-71. doi: 10.1016/j.bbacli.2015.12.003. eCollection 2016 Jun.
3. Barak S, etal., Neuropsychopharmacology. 2009 Jun;34(7):1753-63. doi: 10.1038/npp.2008.232. Epub 2009 Jan 21.
4. Catassi A, etal., Eur J Cancer. 2008 Oct;44(15):2296-311. doi: 10.1016/j.ejca.2008.06.045. Epub 2008 Aug 20.
5. Chianello Nicolau M, etal., World J Gastroenterol. 2016 Aug 21;22(31):7146-56. doi: 10.3748/wjg.v22.i31.7146.
6. Freedman R, etal., Proc Natl Acad Sci U S A 1997 Jan 21;94(2):587-92.
7. Li Z, etal., Acta Histochem. 2019 Aug;121(6):742-749. doi: 10.1016/j.acthis.2019.07.001. Epub 2019 Jul 3.
8. MGD and Homologene mouse data transfer
9. MGD data from the GO Consortium
10. MGD IEA
11. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
12. Pacini A, etal., Pain. 2010 Sep;150(3):542-549. doi: 10.1016/j.pain.2010.06.014. Epub 2010 Jul 8.
13. Paleari L, etal., Am J Respir Crit Care Med. 2009 Jun 15;179(12):1141-50. doi: 10.1164/rccm.200806-908OC. Epub 2009 Jan 16.
14. Paleari L, etal., Int J Cancer. 2009 Jul 1;125(1):199-211. doi: 10.1002/ijc.24299.
15. RGD automated import pipeline
16. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. RGD automated import pipeline for gene-chemical interactions
18. Tatsumi R, etal., J Med Chem. 2005 Apr 7;48(7):2678-86.
19. Teaktong T, etal., J Neurol Sci 2004 Oct 15;225(1-2):39-49.
20. Toulme E, etal., Mol Pharmacol. 2006 Feb;69(2):576-87. Epub 2005 Nov 10.
21. Wang L, etal., Oncogene. 2021 Mar;40(11):1974-1987. doi: 10.1038/s41388-021-01682-z. Epub 2021 Feb 18.
22. Yang L, etal., Eur J Hum Genet. 2015 Aug;23(8):1019-24. doi: 10.1038/ejhg.2014.229. Epub 2014 Nov 19.
23. Young JW, etal., Neuropsychopharmacology. 2004 May;29(5):891-900. doi: 10.1038/sj.npp.1300393.
Additional References at PubMed
PMID:1400473   PMID:7601470   PMID:8563774   PMID:8804729   PMID:8838678   PMID:9037516   PMID:9364063   PMID:9495872   PMID:9580980   PMID:9602068   PMID:10095079   PMID:10349636  
PMID:10454356   PMID:10800961   PMID:10942027   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11222635   PMID:11404397   PMID:11409732   PMID:11790724   PMID:11790782   PMID:11834293  
PMID:11854451   PMID:11906696   PMID:11912199   PMID:12059039   PMID:12079404   PMID:12225896   PMID:12391028   PMID:12438103   PMID:12508119   PMID:12562921   PMID:12606407   PMID:12628457  
PMID:14499477   PMID:14975691   PMID:15009674   PMID:15140935   PMID:15364017   PMID:15489024   PMID:15494367   PMID:15541879   PMID:15549469   PMID:15555774   PMID:15723228   PMID:15770102  
PMID:15896732   PMID:15922075   PMID:15925141   PMID:15926916   PMID:15944242   PMID:15948184   PMID:15963492   PMID:15969741   PMID:16025111   PMID:16025117   PMID:16033766   PMID:16141072  
PMID:16141073   PMID:16253349   PMID:16280085   PMID:16313899   PMID:16319313   PMID:16545784   PMID:16602821   PMID:16650968   PMID:16772172   PMID:16785311   PMID:16873770   PMID:16901939  
PMID:16923147   PMID:17010324   PMID:17016705   PMID:17019565   PMID:17136517   PMID:17158331   PMID:17192639   PMID:17204496   PMID:17218065   PMID:17291692   PMID:17292512   PMID:17431097  
PMID:17434683   PMID:17462791   PMID:17470777   PMID:17520028   PMID:17584502   PMID:17640819   PMID:17675251   PMID:17898222   PMID:17898229   PMID:17920082   PMID:17935702   PMID:17981562  
PMID:18036335   PMID:18077004   PMID:18083057   PMID:18162309   PMID:18184829   PMID:18199426   PMID:18387948   PMID:18439427   PMID:18458158   PMID:18568021   PMID:18584048   PMID:18627272  
PMID:18799693   PMID:18831991   PMID:18848921   PMID:19079602   PMID:19100751   PMID:19111588   PMID:19116908   PMID:19118188   PMID:19170184   PMID:19228980   PMID:19230830   PMID:19246390  
PMID:19344760   PMID:19368846   PMID:19374941   PMID:19481555   PMID:19573576   PMID:19587288   PMID:19615981   PMID:19626424   PMID:19785985   PMID:19808646   PMID:19846875   PMID:19949071  
PMID:20072781   PMID:20128845   PMID:20164328   PMID:20374280   PMID:20377613   PMID:20498043   PMID:20592195   PMID:20595621   PMID:20615555   PMID:20624304   PMID:20659128   PMID:20706987  
PMID:20713028   PMID:20720594   PMID:20843956   PMID:20943921   PMID:20974182   PMID:20974225   PMID:20976039   PMID:21135238   PMID:21143250   PMID:21143907   PMID:21150899   PMID:21173343  
PMID:21239433   PMID:21267068   PMID:21293018   PMID:21339364   PMID:21368056   PMID:21406211   PMID:21436053   PMID:21437621   PMID:21485013   PMID:21491433   PMID:21501254   PMID:21584864  
PMID:21679297   PMID:21784975   PMID:21828053   PMID:21836018   PMID:21873635   PMID:21901321   PMID:21966399   PMID:22009521   PMID:22039094   PMID:22084248   PMID:22183893   PMID:22246862  
PMID:22281823   PMID:22291029   PMID:22314319   PMID:22359587   PMID:22462479   PMID:22473653   PMID:22483693   PMID:22490926   PMID:22577141   PMID:22624500   PMID:22647603   PMID:22649244  
PMID:22666322   PMID:22688057   PMID:22699919   PMID:22749860   PMID:22820264   PMID:22848433   PMID:22871384   PMID:22956824   PMID:23106973   PMID:23270857   PMID:23280428   PMID:23325242  
PMID:23396188   PMID:23431145   PMID:23431157   PMID:23469197   PMID:23521765   PMID:23583933   PMID:23613527   PMID:23616534   PMID:23637989   PMID:23739962   PMID:23769729   PMID:23795917  
PMID:23811311   PMID:23811428   PMID:23831952   PMID:23842742   PMID:23851693   PMID:23954803   PMID:24049141   PMID:24133259   PMID:24194600   PMID:24289814   PMID:24298024   PMID:24326163  
PMID:24349346   PMID:24350834   PMID:24360204   PMID:24366190   PMID:24381265   PMID:24381273   PMID:24412630   PMID:24454942   PMID:24462939   PMID:24561218   PMID:24562381   PMID:24607281  
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PMID:24952961   PMID:24983521   PMID:25049388   PMID:25071454   PMID:25093893   PMID:25157794   PMID:25296021   PMID:25324572   PMID:25345495   PMID:25352454   PMID:25352741   PMID:25365546  
PMID:25396421   PMID:25453771   PMID:25497451   PMID:25683697   PMID:25797465   PMID:25803612   PMID:25816313   PMID:25826262   PMID:25887272   PMID:25895149   PMID:25937212   PMID:25948261  
PMID:25985797   PMID:25990637   PMID:26079645   PMID:26222090   PMID:26285576   PMID:26295309   PMID:26451017   PMID:26522221   PMID:26650489   PMID:26658876   PMID:26842251   PMID:26921769  
PMID:26925951   PMID:26937017   PMID:26947072   PMID:26965141   PMID:26999808   PMID:27088805   PMID:27103432   PMID:27129882   PMID:27129924   PMID:27233215   PMID:27339462   PMID:27471776  
PMID:27522251   PMID:27572255   PMID:27626380   PMID:27676657   PMID:27729414   PMID:27752043   PMID:27821848   PMID:27834689   PMID:28112735   PMID:28202387   PMID:28241318   PMID:28243714  
PMID:28258105   PMID:28282360   PMID:28288124   PMID:28349965   PMID:28384302   PMID:28479102   PMID:28529954   PMID:28551099   PMID:28576119   PMID:28606623   PMID:28696300   PMID:28725182  
PMID:28822039   PMID:28858686   PMID:28941191   PMID:28955208   PMID:29018331   PMID:29114104   PMID:29117258   PMID:29128415   PMID:29197398   PMID:29261717   PMID:29265373   PMID:29326174  
PMID:29358666   PMID:29580318   PMID:29674665   PMID:29870540   PMID:29975102   PMID:29992246   PMID:30270436   PMID:30345917   PMID:30397183   PMID:30429582   PMID:30515567   PMID:30670317  
PMID:30806956   PMID:30862827   PMID:30947238   PMID:30967878   PMID:30971711   PMID:31127002   PMID:31202708   PMID:31236857   PMID:31780901   PMID:31904546   PMID:32003755   PMID:32018068  
PMID:32028688   PMID:32204458   PMID:32413437   PMID:32521265   PMID:32522255   PMID:32552811   PMID:32619677   PMID:32708537   PMID:32770411   PMID:32817250   PMID:32950676   PMID:32980459  
PMID:33109433   PMID:33110180   PMID:33117372   PMID:33141376   PMID:33239400   PMID:33398432   PMID:33422641   PMID:33902624   PMID:33953172   PMID:34321999   PMID:34512319   PMID:34514543  
PMID:34518365   PMID:34721415   PMID:34782794   PMID:34792616   PMID:34809734   PMID:34910920   PMID:34943798   PMID:35087060   PMID:35413868   PMID:35431807   PMID:35479080  


Genomics

Comparative Map Data
Chrna7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39762,748,440 - 62,862,274 (-)NCBIGRCm39mm39
GRCm39 Ensembl762,748,440 - 62,862,317 (-)Ensembl
GRCm38763,098,692 - 63,212,526 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl763,098,692 - 63,212,569 (-)EnsemblGRCm38mm10GRCm38
MGSCv37770,243,578 - 70,357,412 (-)NCBIGRCm37mm9NCBIm37
MGSCv36762,977,642 - 63,091,468 (-)NCBImm8
Celera760,542,827 - 60,660,378 (-)NCBICelera
Cytogenetic Map7CNCBI
cM Map734.47NCBI
CHRNA7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381532,030,483 - 32,173,018 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1531,923,438 - 32,173,018 (+)EnsemblGRCh38hg38GRCh38
GRCh371532,322,686 - 32,465,219 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361530,110,018 - 30,248,541 (+)NCBINCBI36hg18NCBI36
Build 341530,110,017 - 30,248,525NCBI
Celera158,162,865 - 8,292,202 (-)NCBI
Cytogenetic Map15q13.3NCBI
HuRef159,499,328 - 9,603,273 (+)NCBIHuRef
CHM1_11532,312,897 - 32,452,812 (+)NCBICHM1_1
Chrna7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21116,715,286 - 116,837,223 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1116,714,711 - 116,837,240 (-)Ensembl
Rnor_6.01123,897,341 - 124,039,263 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1123,899,657 - 124,039,196 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01125,029,451 - 125,158,153 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41117,587,580 - 117,716,267 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11117,665,347 - 117,794,621 (-)NCBI
Celera1108,976,664 - 109,097,764 (-)NCBICelera
Cytogenetic Map1q22NCBI
Chrna7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541630,687,478 - 30,798,700 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541630,687,518 - 30,798,700 (+)NCBIChiLan1.0ChiLan1.0
CHRNA7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11529,565,885 - 29,705,194 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1529,565,885 - 29,705,194 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01510,525,535 - 10,667,227 (+)NCBIMhudiblu_PPA_v0panPan3
CHRNA7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1336,852,082 - 37,164,930 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl336,852,543 - 36,978,399 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha339,517,659 - 39,644,156 (-)NCBI
ROS_Cfam_1.0337,232,973 - 37,359,572 (-)NCBI
UMICH_Zoey_3.1336,756,424 - 36,882,829 (-)NCBI
UNSW_CanFamBas_1.0337,011,929 - 37,138,401 (-)NCBI
UU_Cfam_GSD_1.0337,222,873 - 37,349,426 (-)NCBI
Chrna7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640146,502,956 - 146,512,072 (+)NCBI
SpeTri2.0NW_00493735132,324 - 46,871 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CHRNA7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1142,803,698 - 142,937,788 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11142,803,697 - 142,937,124 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21158,717,002 - 158,849,994 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CHRNA7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12650,554,143 - 50,686,847 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2650,551,829 - 50,686,803 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604890,139,706 - 90,283,400 (+)NCBIVero_WHO_p1.0
Chrna7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624768908,907 - 1,024,953 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
L37663  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38763,099,013 - 63,099,123UniSTSGRCm38
MGSCv37770,243,899 - 70,244,009UniSTSGRCm37
Celera760,543,148 - 60,543,258UniSTS
Cytogenetic Map7CUniSTS
cM Map730.0UniSTS
Whitehead/MRC_RH7723.3UniSTS
D7Mit176  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38763,211,190 - 63,211,340UniSTSGRCm38
MGSCv37770,356,076 - 70,356,226UniSTSGRCm37
Celera760,659,046 - 60,659,192UniSTS
Cytogenetic Map7CUniSTS
cM Map727.0UniSTS
Whitehead Genetic726.2UniSTS
UniSTS:224382  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38763,098,978 - 63,099,129UniSTSGRCm38
MGSCv37770,243,864 - 70,244,015UniSTSGRCm37
Celera760,543,113 - 60,543,264UniSTS
Cytogenetic Map7CUniSTS
cM Map730.0UniSTS
Chrna7  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7CUniSTS
cM Map730.0UniSTS
fi15f09.x1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38763,145,649 - 63,147,226UniSTSGRCm38
MGSCv37770,290,535 - 70,292,112UniSTSGRCm37
Celera760,589,703 - 60,591,247UniSTS
Celera760,589,703 - 60,591,324UniSTS
Cytogenetic Map7CUniSTS
cM Map730.0UniSTS
Chrna7  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7CUniSTS


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300722Sle3_msystemic lupus erythmatosus susceptibility 3 (mouse)Not determined7351172887142720Mouse
38501068Tip1_mtuberculosis immunophenotype 1, spleen CFU (mouse)7360299972549748Mouse
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76502999133501729Mouse
12792978Fbmd3_mfemoral bone mineral density 3, females only (mouse)77050288142367832Mouse
10412199Sst2_msusceptibility to tuberculosis 2 (mouse)Not determined718728794119485380Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719147398141919804Mouse
4141805Sle19_msystematic lupus erythematosus susceptibility 19 (mouse)Not determined3003248581135653Mouse
26884404Huml1_mhumerus length 1, 5 week (mouse)730199425108999207Mouse
1301175Ap7q_malcohol preference 7 QTL (mouse)Not determined73171484565715077Mouse
1300996Aorls2_maortic lesion size 2 (mouse)Not determined73239453266394681Mouse
1559000Ossc1_mosteosarcoma susceptibility 1 (mouse)Not determined73405302568053223Mouse
10045622Heal20_mwound healing/regeneration 20 (mouse)Not determined73431688768317043Mouse
1357586Mdmsc3_mmodifier of muscularity 3 (mouse)Not determined73444786968448018Mouse
1301514Rigs1_mradiation induced gastroschisis 1 (mouse)Not determined73628001592394346Mouse
1301082Bbaa16_mB.burgdorferi-associated arthritis 16 (mouse)Not determined736280015116416877Mouse
25314301Vmm3_mvariable multisystem mineralization 3, lung (mouse)73729942572049748Mouse
25314303Vmm4_mvariable multisystem mineralization 4, kidney (mouse)73729942587049208Mouse
1300878Skts1_mskin tumor susceptibility 1 (mouse)Not determined73789138671891582Mouse
10402488Dipa2_mdrug induced psychomotor activation 2 (mouse)Not determined73842154872421684Mouse
1300791Abbp3_mA/J and C57BL/6 blood pressure 3 (mouse)Not determined739673887103510010Mouse
11252140Fdr1_mfat response to dietary restriction 1 (mouse)74114882075148965Mouse
4141929Chlq18_mcirculating hormone level QTL 18 (mouse)Not determined74114882075148965Mouse
10043926Bw1n_mbody weight 1 in NSY (mouse)Not determined745161966118693530Mouse
12880417V125Dq5_mvitamin D active form serum level QTL 5 (mouse)74524974879249748Mouse
25314302Vmm2_mvariable multisystem mineralization 2, heart (mouse)74714974874149748Mouse
12738423Lfibq6_mliver fibrosis QTL 6 (mouse)74769437866704862Mouse
1302141Fcsa6_mfemoral cross-sectional area 6 (mouse)Not determined74838446182384607Mouse
11532741Tbrs5_mtuberculosis resistance 5 (mouse)74915922783235415Mouse
1357752Tabw_mtally ho asscoiated body weight (mouse)Not determined74919327883193390Mouse
10053685Eae43_mexperimental allergic encephalomyelitis susceptibility 43 (mouse)Not determined75112495485125093Mouse
10054064Bwq11_mbody weight QTL 11 (mouse)Not determined75112495485125093Mouse
13208555Lgth10_mbody length 10 (mouse)751649748125599172Mouse
12880418V125Dq6_mvitamin D active form serum level QTL 6 (mouse)75214974886149748Mouse
27226751Femd5_mfemur midshaft diameter 5, 10 week (mouse)753249748143153737Mouse
25823170Hrsq7_mhost response to SARS QTL 7, log titer (mouse)754819589116822815Mouse
11565101Tsve1_mvariable short tail (Tsv) enhancer 1 (mouse)75588950887142720Mouse
27226778Femd11_mfemur midshaft diameter 11, 16 week (mouse)756949748134001729Mouse
1300952Hcs1_mhepatocarcinogenesis susceptibility 1 (mouse)Not determined75732612191326352Mouse
1301465Egrm3_mearly growth rate (mouse)Not determined75732612191326352Mouse
1301663Skull9_mskull morphology 9 (mouse)Not determined75732612191326352Mouse
13432171Rosd1_mrotarod saline difference 1 (mouse)75919437869004862Mouse
26884408Bzwq13_mbi-zygomatic width QTL 13, 16 week (mouse)761749748121399223Mouse
27095916Scvln15_msacral vertebrae length 2, 16 week (mouse)761749748123699223Mouse
25314305Vmm6_mvariable multisystem mineralization 6, eye (mouse)761849748102749207Mouse
13506761Tbthq1_mtrabecular bone thickness QTL 1 (mouse)76234974867749748Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:154
Count of miRNA genes:141
Interacting mature miRNAs:149
Transcripts:ENSMUST00000032738
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000032738   ⟹   ENSMUSP00000032738
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl762,748,440 - 62,862,261 (-)Ensembl
GRCm38.p6 Ensembl763,098,692 - 63,212,513 (-)Ensembl
RefSeq Acc Id: ENSMUST00000208304
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl762,789,173 - 62,862,317 (-)Ensembl
GRCm38.p6 Ensembl763,139,425 - 63,212,569 (-)Ensembl
RefSeq Acc Id: NM_007390   ⟹   NP_031416
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39762,748,440 - 62,862,274 (-)NCBI
GRCm38763,098,692 - 63,212,526 (-)ENTREZGENE
MGSCv37770,243,578 - 70,357,412 (-)RGD
Celera760,542,827 - 60,660,378 (-)RGD
cM Map7 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_031416   ⟸   NM_007390
- Peptide Label: precursor
- UniProtKB: P49582 (UniProtKB/Swiss-Prot),   Q53YJ9 (UniProtKB/TrEMBL),   Q8CC01 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000032738   ⟸   ENSMUST00000032738
Protein Domains
Neur_chan_LBD   Neur_chan_memb

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P49582-F1-model_v2 AlphaFold P49582 1-502 view protein structure

Promoters
RGD ID:8664323
Promoter ID:EPDNEW_M10193
Type:multiple initiation site
Name:Chrna7_1
Description:Mus musculus cholinergic receptor, nicotinic, alpha polypeptide7 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38763,212,522 - 63,212,582EPDNEW
RGD ID:6840834
Promoter ID:MM_KWN:50891
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   ES_Cell
Transcripts:ENSMUST00000064671,   NM_007390
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36770,357,181 - 70,357,681 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:99779 AgrOrtholog
Ensembl Genes ENSMUSG00000030525 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000032738 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000032738 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.58.390 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.70.170.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Neur_chan_lig-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neur_chan_lig-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neur_channel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neuro-gated_channel_TM_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neuro_actylchol_rec UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neurotrans-gated_channel_TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neurotransmitter_ion_chnl_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nicotinic_acetylcholine_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:11441 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:99779 ENTREZGENE
NCBI Gene 11441 ENTREZGENE
PANTHER PTHR18945 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Neur_chan_LBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neur_chan_memb UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB CHRNA7 RGD
PhenoGen Chrna7 PhenoGen
PRINTS NICOTINICR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NRIONCHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE NEUROTR_ION_CHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF63712 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF90112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs LIC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt ACHA7_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q53YJ9 ENTREZGENE, UniProtKB/TrEMBL
  Q8CC01 ENTREZGENE, UniProtKB/TrEMBL
  Q8VI09_MOUSE UniProtKB/TrEMBL
  Q9JHD6_MOUSE UniProtKB/TrEMBL