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Gene: Chrna7 (cholinergic receptor, nicotinic, alpha polypeptide 7) Mus musculus
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Symbol: Chrna7
Name: cholinergic receptor, nicotinic, alpha polypeptide 7
Description: Exhibits acetylcholine-gated cation-selective channel activity. Predicted to contribute to acetylcholine receptor activity and extracellular ligand-gated ion channel activity. Involved in several processes, including modulation of chemical synaptic transmission; negative regulation of cytokine production; and regulation of protein metabolic process. Localizes to several cellular components, including the axolemma; cholinergic synapse; and integral component of synaptic membrane. Used to study schizophrenia. Human ortholog(s) of this gene implicated in schizophrenia. Is expressed in several structures, including hemolymphoid system; nervous system; paravertebral ganglion; retina; and tongue. Orthologous to several human genes including CHRFAM7A (CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion); PARTICIPATES IN acetylcholine signaling pathway via nicotinic acetylcholine receptor; INTERACTS WITH (S)-nicotine; all-trans-retinoic acid; carbon nanotube.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: acetylcholine receptor alpha 7 neural; Acra7; alpha7; alpha7 nicotinic receptor; alpha7-nAChR; nAchR; neuronal acetylcholine receptor subunit alpha-7
Orthologs:
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38763,098,692 - 63,212,526 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37770,243,578 - 70,357,412 (-)NCBIGRCm37mm9NCBIm37
MGSCv36762,977,642 - 63,091,468 (-)NCBImm8
Celera760,542,827 - 60,660,378 (-)NCBICelera
Cytogenetic Map7 CNCBI
cM Map734.47NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
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Additional Information

External Database Links
 
More on Chrna7
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 10357
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2019-11-13
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.