Chrna7 (cholinergic receptor, nicotinic, alpha polypeptide 7) - Rat Genome Database
Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Chrna7 (cholinergic receptor, nicotinic, alpha polypeptide 7) Mus musculus
Analyze
Symbol: Chrna7
Name: cholinergic receptor, nicotinic, alpha polypeptide 7
RGD ID: 10357
MGI Page MGI
Description: Exhibits acetylcholine-gated cation-selective channel activity. Predicted to contribute to acetylcholine receptor activity. Involved in several processes, including modulation of chemical synaptic transmission; negative regulation of cytokine production; and regulation of protein metabolic process. Localizes to several cellular components, including axolemma; cholinergic synapse; and integral component of synaptic membrane. Is expressed in several structures, including alimentary system; nervous system; retina; and thymus. Used to study schizophrenia. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to several human genes including CHRFAM7A (CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion); PARTICIPATES IN acetylcholine signaling pathway via nicotinic acetylcholine receptor; INTERACTS WITH (S)-nicotine; 1,2-dichloroethane; acetamiprid.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Ac; acetylcholine receptor alpha 7 neural; Acra7; al; alpha7; alpha7 nicotinic receptor; alpha7-nAChR; nAchR; neuronal acetylcholine receptor subunit alpha-7
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39762,748,440 - 62,862,274 (-)NCBIGRCm39mm39
GRCm38763,098,692 - 63,212,526 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl763,098,692 - 63,212,569 (-)EnsemblGRCm38mm10GRCm38
MGSCv37770,243,578 - 70,357,412 (-)NCBIGRCm37mm9NCBIm37
MGSCv36762,977,642 - 63,091,468 (-)NCBImm8
Celera760,542,827 - 60,660,378 (-)NCBICelera
Cytogenetic Map7CNCBI
cM Map734.47NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-beta-thujone  (ISO)
(-)-cotinine  (ISO)
(-)-lobeline  (ISO)
(R)-adrenaline  (ISO)
(S)-nicotine  (EXP,ISO)
1,1-dimethyl-4-phenylpiperazinium iodide  (ISO)
1,2-dichloroethane  (EXP)
13-desmethylspirolide C  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
5-hydroxyindole  (ISO)
6-propyl-2-thiouracil  (ISO)
acetamiprid  (EXP)
acetylcholine  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP)
ammonium chloride  (ISO)
Anabaseine  (ISO)
Anatoxin a  (ISO)
atracurium  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (ISO)
butanal  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
carbachol  (ISO)
carbon nanotube  (EXP)
chlorpyrifos  (EXP,ISO)
choline  (EXP,ISO)
cisatracurium  (ISO)
cisplatin  (ISO)
Citreoviridin  (EXP)
cytisine  (ISO)
dextran sulfate  (EXP)
Diacetoxyscirpenol  (EXP)
diazinon  (ISO)
dieldrin  (ISO)
dihydro-beta-erythroidine  (ISO)
dinophysistoxin 1  (ISO)
dioxygen  (EXP)
doxorubicin  (ISO)
epibatidine  (ISO)
ethanol  (EXP,ISO)
galanthamine  (EXP)
galanthamine Trifluoroacetic acid  (EXP)
GW 4064  (EXP)
herbicide  (EXP)
lovastatin  (ISO)
LY294002  (ISO)
manganese(II) chloride  (EXP)
Mecamylamine  (ISO)
melittin  (ISO)
methyllycaconitine  (EXP,ISO)
Mivacurium  (ISO)
N-butyl-N-(4-hydroxybutyl)nitrosamine  (ISO)
N-nitrosodiethylamine  (ISO)
nickel atom  (ISO)
nicotine  (EXP,ISO)
okadaic acid  (ISO)
ozone  (EXP)
pancuronium  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
parathion-methyl  (ISO)
PCB138  (ISO)
potassium dichromate  (EXP)
propanal  (ISO)
rocuronium  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
spinosad  (ISO)
suramin  (EXP)
testosterone  (ISO)
tetrachloroethene  (ISO)
tetrodotoxin  (ISO)
titanium dioxide  (EXP)
toluene  (ISO)
topiramate  (ISO)
tubocurarine  (ISO)
urethane  (ISO)
varenicline  (ISO)
vecuronium bromide  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acetylcholine receptor signaling pathway  (ISO)
activation of MAPK activity  (ISO)
associative learning  (IGI,IMP)
B cell activation  (IMP)
behavioral response to ethanol  (IMP)
behavioral response to nicotine  (IGI)
calcium ion transport  (ISO)
cellular calcium ion homeostasis  (ISO)
chemical synaptic transmission  (IBA)
cognition  (ISO)
dendrite arborization  (IMP)
dendritic spine organization  (IMP)
dopamine biosynthetic process  (ISO)
endocytosis  (IMP)
flagellated sperm motility  (IMP)
generation of ovulation cycle rhythm  (IMP)
ion transmembrane transport  (IBA,ISO)
ion transport  (IMP)
learning or memory  (IGI)
memory  (IMP,ISO)
modulation of chemical synaptic transmission  (IGI)
modulation of excitatory postsynaptic potential  (IDA,IGI)
negative regulation of amyloid-beta formation  (ISO)
negative regulation of ERK1 and ERK2 cascade  (ISO)
negative regulation of inflammatory response  (IMP)
negative regulation of interleukin-1 beta production  (IMP)
negative regulation of interleukin-6 production  (IMP)
negative regulation of protein phosphorylation  (IDA)
negative regulation of tumor necrosis factor production  (IMP,ISO)
nervous system process  (IBA)
neuronal action potential  (ISO)
ovulation cycle  (IMP)
positive regulation of acetylcholine biosynthetic process  (IC)
positive regulation of amyloid-beta formation  (IGI)
positive regulation of angiogenesis  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of CoA-transferase activity  (IGI)
positive regulation of ERK1 and ERK2 cascade  (IDA,IGI,IMP,ISO)
positive regulation of excitatory postsynaptic potential  (IGI)
positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure  (IMP)
positive regulation of long-term synaptic potentiation  (IDA,IGI)
positive regulation of peptidyl-serine phosphorylation  (IMP)
positive regulation of protein metabolic process  (IGI)
positive regulation of protein phosphorylation  (IDA)
regulation of amyloid fibril formation  (IGI)
regulation of amyloid precursor protein catabolic process  (ISO)
regulation of inflammatory response  (IMP)
regulation of membrane potential  (IBA,IMP,ISO)
regulation of neuron death  (IGI)
regulation of norepinephrine secretion  (IMP)
regulation of synapse structural plasticity  (IC)
regulation of synaptic transmission, cholinergic  (IC)
regulation of synaptic transmission, dopaminergic  (IMP)
regulation of synaptic vesicle exocytosis  (ISO)
response to acetylcholine  (ISO)
response to amyloid-beta  (IMP)
response to cold  (IDA)
response to ethanol  (IMP)
response to food  (IMP)
response to hypoxia  (ISO)
response to nicotine  (IGI,IMP,ISO)
sensory processing  (IDA,ISO)
signal transduction  (IBA,ISO)
synapse organization  (IGI)
synaptic transmission, cholinergic  (IBA,IMP,ISO)
T cell activation  (IMP)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal abdominal wall morphology  (IAGP)
abnormal airway basal cell differentiation  (IAGP)
abnormal bone structure  (IEA)
abnormal brain interneuron morphology  (IAGP)
abnormal brain morphology  (IAGP)
abnormal cerebral cortex morphology  (IAGP)
abnormal cerebral cortex pyramidal cell morphology  (IAGP)
abnormal circulating cholesterol level  (IEA)
abnormal circulating HDL cholesterol level  (IEA)
abnormal craniofacial morphology  (IAGP)
abnormal dorsal root ganglion morphology  (IAGP)
abnormal excitatory postsynaptic potential  (IAGP)
abnormal GABA-mediated receptor currents  (IAGP)
abnormal GABAergic neuron morphology  (IAGP)
abnormal GABAergic neuron physiology  (IAGP)
abnormal interleukin level  (IAGP)
abnormal limb bone morphology  (IAGP)
abnormal myeloblast morphology/development  (IAGP)
abnormal nicotine-mediated receptor currents  (IAGP)
abnormal retinal pigment epithelium morphology  (IAGP)
abnormal rostral-caudal axis patterning  (IAGP)
abnormal seizure response to pharmacological agent  (IAGP)
abnormal somatosensory cortex morphology  (IAGP)
abnormal spatial learning  (IAGP)
abnormal spatial working memory  (IAGP)
abnormal suckling behavior  (IAGP)
abnormal tail morphology  (IAGP)
abnormal tumor necrosis factor level  (IAGP)
airway basal cell hyperplasia  (IAGP)
anemia  (IAGP)
asthenozoospermia  (IAGP)
decreased anxiety-related response  (IAGP)
decreased CNS synapse formation  (IAGP)
decreased erythroblast number  (IAGP)
decreased IgG level  (IAGP)
decreased immunoglobulin level  (IAGP)
decreased litter size  (IAGP)
decreased neutrophil cell number  (IAGP)
delayed caudal neuropore closure  (IAGP)
dorsal root ganglion hypoplasia  (IAGP)
enhanced coordination  (IAGP)
enlarged liver  (IAGP)
enlarged pancreas  (IAGP)
enlarged salivary gland  (IAGP)
failure of neuromuscular synapse presynaptic differentiation  (IAGP)
flat head  (IAGP)
hunched posture  (IAGP)
hyperactivity  (IAGP)
hypoactivity  (IAGP)
impaired olfaction  (IAGP)
impaired passive avoidance behavior  (IAGP)
increased lymphocyte cell number  (IAGP)
increased neuron apoptosis  (IAGP)
macrodontia  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
no abnormal phenotype detected  (IAGP)
omphalocele  (IAGP)
perinatal lethality, complete penetrance  (IAGP)
prolonged estrous cycle  (IAGP)
reduced female fertility  (IAGP)
reduced fertility  (IAGP)
short mandible  (IAGP)
spina bifida  (IAGP)
tremors  (IAGP)
References

Additional References at PubMed
PMID:1400473   PMID:7601470   PMID:8563774   PMID:8804729   PMID:8838678   PMID:9037516   PMID:9364063   PMID:9495872   PMID:9580980   PMID:9602068   PMID:10095079   PMID:10349636  
PMID:10454356   PMID:10800961   PMID:10942027   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11222635   PMID:11404397   PMID:11409732   PMID:11790724   PMID:11790782   PMID:11834293  
PMID:11854451   PMID:11906696   PMID:11912199   PMID:12059039   PMID:12079404   PMID:12225896   PMID:12391028   PMID:12438103   PMID:12508119   PMID:12562921   PMID:12606407   PMID:12628457  
PMID:14499477   PMID:14970827   PMID:14975691   PMID:15009674   PMID:15140935   PMID:15364017   PMID:15489024   PMID:15494367   PMID:15541879   PMID:15549469   PMID:15555774   PMID:15723228  
PMID:15770102   PMID:15896732   PMID:15922075   PMID:15925141   PMID:15926916   PMID:15944242   PMID:15948184   PMID:15963492   PMID:15969741   PMID:16025111   PMID:16025117   PMID:16033766  
PMID:16141072   PMID:16141073   PMID:16253349   PMID:16280085   PMID:16313899   PMID:16319313   PMID:16545784   PMID:16602821   PMID:16650968   PMID:16772172   PMID:16785311   PMID:16873770  
PMID:16901939   PMID:16923147   PMID:17010324   PMID:17016705   PMID:17019565   PMID:17136517   PMID:17158331   PMID:17192639   PMID:17204496   PMID:17218065   PMID:17291692   PMID:17292512  
PMID:17431097   PMID:17434683   PMID:17462791   PMID:17470777   PMID:17520028   PMID:17584502   PMID:17640819   PMID:17675251   PMID:17898222   PMID:17898229   PMID:17920082   PMID:17935702  
PMID:17981562   PMID:18036335   PMID:18077004   PMID:18083057   PMID:18162309   PMID:18184829   PMID:18199426   PMID:18387948   PMID:18439427   PMID:18458158   PMID:18568021   PMID:18584048  
PMID:18627272   PMID:18799693   PMID:18831991   PMID:18848921   PMID:19079602   PMID:19100751   PMID:19111588   PMID:19116908   PMID:19118188   PMID:19170184   PMID:19228980   PMID:19230830  
PMID:19246390   PMID:19344760   PMID:19368846   PMID:19374941   PMID:19481555   PMID:19573576   PMID:19587288   PMID:19615981   PMID:19626424   PMID:19785985   PMID:19808646   PMID:19846875  
PMID:19949071   PMID:20072781   PMID:20128845   PMID:20164328   PMID:20374280   PMID:20377613   PMID:20498043   PMID:20592195   PMID:20595621   PMID:20615555   PMID:20624304   PMID:20659128  
PMID:20706987   PMID:20713028   PMID:20720594   PMID:20843956   PMID:20943921   PMID:20974182   PMID:20974225   PMID:20976039   PMID:21135238   PMID:21143250   PMID:21143907   PMID:21150899  
PMID:21173343   PMID:21239433   PMID:21267068   PMID:21293018   PMID:21339364   PMID:21368056   PMID:21406211   PMID:21436053   PMID:21437621   PMID:21485013   PMID:21491433   PMID:21501254  
PMID:21584864   PMID:21679297   PMID:21784975   PMID:21828053   PMID:21836018   PMID:21873635   PMID:21901321   PMID:21966399   PMID:22009521   PMID:22084248   PMID:22183893   PMID:22246862  
PMID:22281823   PMID:22291029   PMID:22314319   PMID:22359587   PMID:22462479   PMID:22473653   PMID:22483693   PMID:22490926   PMID:22577141   PMID:22624500   PMID:22647603   PMID:22649244  
PMID:22666322   PMID:22688057   PMID:22699919   PMID:22749860   PMID:22820264   PMID:22848433   PMID:22871384   PMID:22956824   PMID:23106973   PMID:23270857   PMID:23280428   PMID:23325242  
PMID:23396188   PMID:23431145   PMID:23431157   PMID:23469197   PMID:23521765   PMID:23583933   PMID:23613527   PMID:23616534   PMID:23637989   PMID:23739962   PMID:23769729   PMID:23795917  
PMID:23811311   PMID:23811428   PMID:23831952   PMID:23842742   PMID:23851693   PMID:23954803   PMID:24049141   PMID:24133259   PMID:24289814   PMID:24298024   PMID:24326163   PMID:24349346  
PMID:24350834   PMID:24360204   PMID:24366190   PMID:24381265   PMID:24381273   PMID:24412630   PMID:24454942   PMID:24462939   PMID:24561218   PMID:24562381   PMID:24607281   PMID:24631336  
PMID:24685552   PMID:24744866   PMID:24747746   PMID:24757672   PMID:24769321   PMID:24811002   PMID:24833065   PMID:24836856   PMID:24837029   PMID:24849809   PMID:24879866   PMID:24952961  
PMID:24983521   PMID:25049388   PMID:25071454   PMID:25093893   PMID:25157794   PMID:25296021   PMID:25324572   PMID:25345495   PMID:25352454   PMID:25352741   PMID:25365546   PMID:25396421  
PMID:25453771   PMID:25497451   PMID:25683697   PMID:25797465   PMID:25803612   PMID:25816313   PMID:25826262   PMID:25887272   PMID:25895149   PMID:25937212   PMID:25948261   PMID:25985797  
PMID:25990637   PMID:26079645   PMID:26222090   PMID:26285576   PMID:26295309   PMID:26451017   PMID:26522221   PMID:26650489   PMID:26658876   PMID:26842251   PMID:26921769   PMID:26925951  
PMID:26937017   PMID:26947072   PMID:26965141   PMID:26999808   PMID:27088805   PMID:27103432   PMID:27129882   PMID:27129924   PMID:27233215   PMID:27339462   PMID:27471776   PMID:27522251  
PMID:27572255   PMID:27626380   PMID:27676657   PMID:27729414   PMID:27752043   PMID:27821848   PMID:27834689   PMID:28112735   PMID:28202387   PMID:28241318   PMID:28243714   PMID:28258105  
PMID:28282360   PMID:28288124   PMID:28349965   PMID:28384302   PMID:28479102   PMID:28529954   PMID:28551099   PMID:28576119   PMID:28606623   PMID:28696300   PMID:28822039   PMID:28858686  
PMID:28941191   PMID:28955208   PMID:29018331   PMID:29114104   PMID:29117258   PMID:29128415   PMID:29197398   PMID:29261717   PMID:29265373   PMID:29326174   PMID:29358666   PMID:29580318  
PMID:29674665   PMID:29870540   PMID:29975102   PMID:29992246   PMID:30270436   PMID:30345917   PMID:30397183   PMID:30429582   PMID:30515567   PMID:30670317   PMID:30806956   PMID:30862827  
PMID:30947238   PMID:30967878   PMID:30971711   PMID:31127002   PMID:31202708   PMID:31236857   PMID:32552811   PMID:32817250  


Genomics

Comparative Map Data
Chrna7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39762,748,440 - 62,862,274 (-)NCBIGRCm39mm39
GRCm38763,098,692 - 63,212,526 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl763,098,692 - 63,212,569 (-)EnsemblGRCm38mm10GRCm38
MGSCv37770,243,578 - 70,357,412 (-)NCBIGRCm37mm9NCBIm37
MGSCv36762,977,642 - 63,091,468 (-)NCBImm8
Celera760,542,827 - 60,660,378 (-)NCBICelera
Cytogenetic Map7CNCBI
cM Map734.47NCBI
CHRNA7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1531,923,438 - 32,173,018 (+)EnsemblGRCh38hg38GRCh38
GRCh381532,030,462 - 32,173,018 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371532,322,686 - 32,462,384 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361530,110,018 - 30,248,541 (+)NCBINCBI36hg18NCBI36
Build 341530,110,017 - 30,248,525NCBI
Celera158,162,865 - 8,292,202 (-)NCBI
Cytogenetic Map15q13.3NCBI
HuRef159,499,328 - 9,603,273 (+)NCBIHuRef
CHM1_11532,312,897 - 32,452,812 (+)NCBICHM1_1
Chrna7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01123,897,341 - 124,039,263 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1123,899,657 - 124,039,196 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01125,029,451 - 125,158,153 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41117,587,580 - 117,716,267 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11117,665,347 - 117,794,621 (-)NCBI
Celera1108,976,664 - 109,097,764 (-)NCBICelera
Cytogenetic Map1q22NCBI
Chrna7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541630,687,478 - 30,798,700 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541630,687,518 - 30,798,700 (+)NCBIChiLan1.0ChiLan1.0
CHRNA7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11529,565,885 - 29,705,194 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1529,565,885 - 29,705,194 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01510,525,535 - 10,667,227 (+)NCBIMhudiblu_PPA_v0panPan3
CHRNA7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl336,852,543 - 36,978,399 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1336,852,082 - 37,164,930 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CHRNA7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1142,803,698 - 142,937,788 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11142,803,697 - 142,937,124 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21158,717,002 - 158,849,994 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CHRNA7
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12650,554,143 - 50,686,847 (-)NCBI
ChlSab1.1 Ensembl2650,551,829 - 50,686,803 (-)Ensembl
Chrna7
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624768908,907 - 1,024,953 (-)NCBI

Position Markers
L37663  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38763,099,013 - 63,099,123UniSTSGRCm38
MGSCv37770,243,899 - 70,244,009UniSTSGRCm37
Celera760,543,148 - 60,543,258UniSTS
Cytogenetic Map7CUniSTS
cM Map730.0UniSTS
Whitehead/MRC_RH7723.3UniSTS
D7Mit176  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38763,211,190 - 63,211,340UniSTSGRCm38
MGSCv37770,356,076 - 70,356,226UniSTSGRCm37
Celera760,659,046 - 60,659,192UniSTS
Cytogenetic Map7CUniSTS
cM Map727.0UniSTS
Whitehead Genetic726.2UniSTS
UniSTS:224382  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38763,098,978 - 63,099,129UniSTSGRCm38
MGSCv37770,243,864 - 70,244,015UniSTSGRCm37
Celera760,543,113 - 60,543,264UniSTS
Cytogenetic Map7CUniSTS
cM Map730.0UniSTS
Chrna7  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7CUniSTS
cM Map730.0UniSTS
fi15f09.x1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38763,145,649 - 63,147,226UniSTSGRCm38
MGSCv37770,290,535 - 70,292,112UniSTSGRCm37
Celera760,589,703 - 60,591,247UniSTS
Celera760,589,703 - 60,591,324UniSTS
Cytogenetic Map7CUniSTS
cM Map730.0UniSTS
Chrna7  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7CUniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300722Sle3_msystemic lupus erythmatosus susceptibility 3 (mouse)Not determined7346321287493512Mouse
38501068Tip1_mtuberculosis immunophenotype 1, spleen CFU (mouse)7360000072900000Mouse
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76500000133900000Mouse
10412199Sst2_msusceptibility to tuberculosis 2 (mouse)Not determined718994869119886157Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719413473142366067Mouse
4141805Sle19_msystematic lupus erythematosus susceptibility 19 (mouse)Not determined3033306081485905Mouse
26884404Huml1_mhumerus length 1, 5 week (mouse)730500000109400000Mouse
1301175Ap7q_malcohol preference 7 QTL (mouse)Not determined73206509766065329Mouse
1300996Aorls2_maortic lesion size 2 (mouse)Not determined73274478466744933Mouse
1559000Ossc1_mosteosarcoma susceptibility 1 (mouse)Not determined73440327768403475Mouse
10045622Heal20_mwound healing/regeneration 20 (mouse)Not determined73466713968667295Mouse
1357586Mdmsc3_mmodifier of muscularity 3 (mouse)Not determined73479812168798270Mouse
1301514Rigs1_mradiation induced gastroschisis 1 (mouse)Not determined73658059092745138Mouse
1301082Bbaa16_mB.burgdorferi-associated arthritis 16 (mouse)Not determined736580590116817642Mouse
25314301Vmm3_mvariable multisystem mineralization 3, lung (mouse)73760000072400000Mouse
25314303Vmm4_mvariable multisystem mineralization 4, kidney (mouse)73760000087400000Mouse
1300878Skts1_mskin tumor susceptibility 1 (mouse)Not determined73824163872241834Mouse
10402488Dipa2_mdrug induced psychomotor activation 2 (mouse)Not determined73877180072771936Mouse
1300791Abbp3_mA/J and C57BL/6 blood pressure 3 (mouse)Not determined740024463103860803Mouse
4141929Chlq18_mcirculating hormone level QTL 18 (mouse)Not determined74149907275499217Mouse
11252140Fdr1_mfat response to dietary restriction 1 (mouse)74149907275499217Mouse
10043926Bw1n_mbody weight 1 in NSY (mouse)Not determined745512542119094307Mouse
12880417V125Dq5_mvitamin D active form serum level QTL 5 (mouse)74560000079600000Mouse
25314302Vmm2_mvariable multisystem mineralization 2, heart (mouse)74750000074500000Mouse
1302141Fcsa6_mfemoral cross-sectional area 6 (mouse)Not determined74873471382734859Mouse
11532741Tbrs5_mtuberculosis resistance 5 (mouse)74950947983586207Mouse
1357752Tabw_mtally ho asscoiated body weight (mouse)Not determined74954353083543642Mouse
10054064Bwq11_mbody weight QTL 11 (mouse)Not determined75147520685475345Mouse
10053685Eae43_mexperimental allergic encephalomyelitis susceptibility 43 (mouse)Not determined75147520685475345Mouse
13208555Lgth10_mbody length 10 (mouse)752000000126000000Mouse
12880418V125Dq6_mvitamin D active form serum level QTL 6 (mouse)75250000086500000Mouse
27226751Femd5_mfemur midshaft diameter 5, 10 week (mouse)753600000143600000Mouse
25823170Hrsq7_mhost response to SARS QTL 7, log titer (mouse)755169841117223580Mouse
11565101Tsve1_mvariable short tail (Tsv) enhancer 1 (mouse)75623976087493512Mouse
27226778Femd11_mfemur midshaft diameter 11, 16 week (mouse)757300000134400000Mouse
1300952Hcs1_mhepatocarcinogenesis susceptibility 1 (mouse)Not determined75767637391676604Mouse
1301465Egrm3_mearly growth rate (mouse)Not determined75767637391676604Mouse
1301663Skull9_mskull morphology 9 (mouse)Not determined75767637391676604Mouse
26884408Bzwq13_mbi-zygomatic width QTL 13, 16 week (mouse)762100000121800000Mouse
27095916Scvln15_msacral vertebrae length 2, 16 week (mouse)762100000124100000Mouse
25314305Vmm6_mvariable multisystem mineralization 6, eye (mouse)762200000103100000Mouse
13506761Tbthq1_mtrabecular bone thickness QTL 1 (mouse)76270000068100000Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:154
Count of miRNA genes:141
Interacting mature miRNAs:149
Transcripts:ENSMUST00000032738
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000032738   ⟹   ENSMUSP00000032738
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl763,098,692 - 63,212,513 (-)Ensembl
RefSeq Acc Id: ENSMUST00000208304
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl763,139,425 - 63,212,569 (-)Ensembl
RefSeq Acc Id: NM_007390   ⟹   NP_031416
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39762,748,440 - 62,862,274 (-)NCBI
GRCm38763,098,692 - 63,212,526 (-)ENTREZGENE
MGSCv37770,243,578 - 70,357,412 (-)RGD
Celera760,542,827 - 60,660,378 (-)RGD
cM Map7 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_031416   ⟸   NM_007390
- Peptide Label: precursor
- UniProtKB: P49582 (UniProtKB/Swiss-Prot),   Q53YJ9 (UniProtKB/TrEMBL),   Q8CC01 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000032738   ⟸   ENSMUST00000032738
Protein Domains
Neur_chan_LBD   Neur_chan_memb

Promoters
RGD ID:8664323
Promoter ID:EPDNEW_M10193
Type:multiple initiation site
Name:Chrna7_1
Description:Mus musculus cholinergic receptor, nicotinic, alpha polypeptide7 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38763,212,522 - 63,212,582EPDNEW
RGD ID:6840834
Promoter ID:MM_KWN:50891
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   ES_Cell
Transcripts:ENSMUST00000064671,   NM_007390
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36770,357,181 - 70,357,681 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:99779 AgrOrtholog
Ensembl Genes ENSMUSG00000030525 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000032738 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000032738 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 2.70.170.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Neur_chan_lig-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neur_chan_lig-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neur_channel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neuro-gated_channel_TM_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neurotrans-gated_channel_TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neurotransmitter_ion_chnl_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nicotinic_acetylcholine_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:11441 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:99779 ENTREZGENE
NCBI Gene 11441 ENTREZGENE
PANTHER PTHR18945 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Neur_chan_LBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neur_chan_memb UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB CHRNA7 RGD
PhenoGen Chrna7 PhenoGen
PRINTS NICOTINICR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NRIONCHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE NEUROTR_ION_CHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF63712 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF90112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs LIC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Mm.113464 ENTREZGENE
UniProt ACHA7_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q53YJ9 ENTREZGENE, UniProtKB/TrEMBL
  Q8CC01 ENTREZGENE, UniProtKB/TrEMBL
  Q8VI09_MOUSE UniProtKB/TrEMBL
  Q9JHD6_MOUSE UniProtKB/TrEMBL