Gene: Chrna7 (cholinergic receptor, nicotinic, alpha polypeptide 7) Mus musculus
Analyze
Symbol:
Chrna7
Name:
cholinergic receptor, nicotinic, alpha polypeptide 7
Description:
Exhibits acetylcholine-gated cation-selective channel activity. Predicted to contribute to acetylcholine receptor activity and extracellular ligand-gated ion channel activity. Involved in several processes, including modulation of chemical synaptic transmission; negative regulation of cytokine production; and regulation of protein metabolic process. Localizes to several cellular components, including the axolemma; cholinergic synapse; and integral component of synaptic membrane. Used to study schizophrenia. Human ortholog(s) of this gene implicated in schizophrenia. Is expressed in several structures, including hemolymphoid system; nervous system; paravertebral ganglion; retina; and tongue. Orthologous to several human genes including CHRFAM7A (CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion); PARTICIPATES IN acetylcholine signaling pathway via nicotinic acetylcholine receptor; INTERACTS WITH (S)-nicotine; all-trans-retinoic acid; carbon nanotube.
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
acetylcholine receptor alpha 7 neural; Acra7; alpha7; alpha7 nicotinic receptor; alpha7-nAChR; nAchR; neuronal acetylcholine receptor subunit alpha-7
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
CHRNA7 (cholinergic receptor nicotinic alpha 7 subunit) HGNC
EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, OMA, OrthoDB, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):
Chrna7 (cholinergic receptor nicotinic alpha 7 subunit) HGNC
EggNOG, OMA, HomoloGene, Inparanoid, Panther, PhylomeDB, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Chrna7 (cholinergic receptor nicotinic alpha 7 subunit) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
CHRNA7 (cholinergic receptor nicotinic alpha 7 subunit) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
CHRNA7 (cholinergic receptor nicotinic alpha 7 subunit) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
CHRNA7 (cholinergic receptor nicotinic alpha 7 subunit) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Other homologs 2
Homo sapiens (human):
CHRFAM7A (CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion) HGNC
Ensembl, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Alliance orthologs 3
Rattus norvegicus (Norway rat):
Chrna7 (cholinergic receptor nicotinic alpha 7 subunit)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)
Homo sapiens (human):
CHRNA7 (cholinergic receptor nicotinic alpha 7 subunit)
Alliance
DIOPT (Ensembl Compara, HGNC, OMA, OrthoFinder, OrthoInspector, PANTHER, TreeFam)
Homo sapiens (human):
CHRFAM7A (CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Danio rerio (zebrafish):
si:ch211-39a7.1
Alliance
DIOPT (OrthoFinder, PANTHER, TreeFam)
Danio rerio (zebrafish):
chrna7 (cholinergic receptor, nicotinic, alpha 7 (neuronal))
Alliance
DIOPT (Ensembl Compara, OMA, OrthoFinder, PANTHER, PhylomeDB, ZFIN)
Caenorhabditis elegans (roundworm):
acr-16
Alliance
DIOPT (Ensembl Compara, Hieranoid, OMA, OrthoFinder, OrthoInspector, PhylomeDB, Roundup, TreeFam)
Caenorhabditis elegans (roundworm):
acr-19
Alliance
DIOPT (Ensembl Compara, InParanoid, OrthoFinder, PANTHER, PhylomeDB, Roundup, TreeFam)
Drosophila melanogaster (fruit fly):
nAChRalpha7
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Caenorhabditis elegans (roundworm):
acr-10
Alliance
DIOPT (Ensembl Compara, PhylomeDB, TreeFam)
Caenorhabditis elegans (roundworm):
acr-11
Alliance
DIOPT (Ensembl Compara, OMA, OrthoFinder, OrthoInspector, PhylomeDB, Roundup, TreeFam)
Caenorhabditis elegans (roundworm):
acr-14
Alliance
DIOPT (Ensembl Compara, PhylomeDB, TreeFam)
Caenorhabditis elegans (roundworm):
acr-15
Alliance
DIOPT (Ensembl Compara, PhylomeDB, TreeFam)
Caenorhabditis elegans (roundworm):
acr-25
Alliance
DIOPT (Ensembl Compara, OrthoFinder, OrthoInspector, PhylomeDB, TreeFam)
Caenorhabditis elegans (roundworm):
acr-7
Alliance
DIOPT (Ensembl Compara, PhylomeDB, TreeFam)
Caenorhabditis elegans (roundworm):
acr-9
Alliance
DIOPT (Ensembl Compara, OMA, OrthoInspector, PhylomeDB, TreeFam)
Caenorhabditis elegans (roundworm):
eat-2
Alliance
DIOPT (Ensembl Compara, PhylomeDB, TreeFam)
Drosophila melanogaster (fruit fly):
nAChRalpha5
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Drosophila melanogaster (fruit fly):
nAChRalpha6
Alliance
DIOPT (Ensembl Compara, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, Roundup, TreeFam)
Latest Assembly:
GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm38 7 63,098,692 - 63,212,526 (-) NCBI GRCm38 GRCm38 mm10 GRCm38 MGSCv37 7 70,243,578 - 70,357,412 (-) NCBI GRCm37 mm9 NCBIm37 MGSCv36 7 62,977,642 - 63,091,468 (-) NCBI mm8 Celera 7 60,542,827 - 60,660,378 (-) NCBI Celera Cytogenetic Map 7 C NCBI cM Map 7 34.47 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Disease Annotations
Imported Annotations - ClinVar
autism spectrum disorder ISO RGD:736847 8554872 ClinVar Annotator: match by term: Autism spectrum disorders ClinVar PMID:20506139 more ... autism spectrum disorder ISO RGD:736847 8554872 ClinVar Annotator: match by term: Autism spectrum disorders ClinVar PMID:21844811 more ... autism spectrum disorder ISO RGD:736847 8554872 ClinVar Annotator: match by term: Autism spectrum disorders ClinVar PMID:19050728 more ... autism spectrum disorder ISO RGD:736847 8554872 ClinVar Annotator: match by term: Autism spectrum disorders ClinVar PMID:20506139 more ... autistic disorder ISO RGD:736847 8554872 ClinVar Annotator: match by term: Autistic disorder of childhood onset ClinVar PMID:21681106 , PMID:30208311 chromosome 15q13.3 microdeletion syndrome ISO RGD:736847 8554872 ClinVar Annotator: match by term: 15q13.3 microdeletion syndrome ClinVar idiopathic generalized epilepsy 7 ISO RGD:736847 8554872 ClinVar Annotator: match by term: Epilepsy, idiopathic generalized 7 ClinVar PMID:25326635 , PMID:25741868 Neurodevelopmental Disorders ISO RGD:736847 8554872 ClinVar Annotator: match by term: Neurodevelopmental disorder ClinVar PMID:25741868 schizophrenia ISO RGD:736847 8554872 ClinVar Annotator: match by term: Schizophrenia ClinVar PMID:21681106 , PMID:30208311
Imported Annotations - CTD
Alzheimer's disease ISO RGD:736847 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:18071042 Auditory Perceptual Disorders ISO RGD:736847 11554173 CTD Direct Evidence: therapeutic CTD PMID:10578459 autistic disorder ISO RGD:736847 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:15046869 Brain Injuries ISO RGD:736847 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:23159883 chromosome 15q13.3 microdeletion syndrome ISO RGD:736847 11554173 CTD Direct Evidence: marker/mechanism CTD Generalized Epilepsy ISO RGD:736847 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:19136953 Lung Neoplasms ISO RGD:736847 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:24089524 Memory Disorders ISO RGD:736847 11554173 CTD Direct Evidence: therapeutic CTD PMID:18848931 Neoplasm Invasiveness ISO RGD:736847 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:18844224 Nerve Degeneration ISO RGD:736847 11554173 CTD Direct Evidence: therapeutic CTD PMID:21715663 Neurobehavioral Manifestations ISO RGD:736847 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:19898479 Spina Bifida Cystica ISO RGD:736847 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:22473653 sudden infant death syndrome ISO RGD:736847 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:22000980 Tobacco Use Disorder ISO RGD:736847 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:24289814 umbilical hernia ISO RGD:736847 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:22473653 visual epilepsy ISO RGD:736847 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:9495872 more ... withdrawal disorder ISO RGD:736847 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:18184829 Imported Annotations - MGI
schizophrenia IEA 13592920 OMIM:181500 MouseDO
(+)-beta-thujone multiple interactions ISO RGD:736847 6480464 beta-thujone inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein], beta-thujone inhibits the reaction [Choline results in increased activity of CHRNA7 protein] CTD PMID:28395994 (-)-cotinine increases response to substance ISO RGD:736847 6480464 CHRNA7 protein mutant form results in increased susceptibility to Cotinine CTD PMID:10082212 (-)-cotinine multiple interactions ISO RGD:736847 6480464 Cotinine binds to and results in increased activity of CHRNA7 protein CTD PMID:10082212 (-)-lobeline affects response to substance ISO RGD:736847 6480464 CHRNA7 protein mutant form affects the susceptibility to Lobeline CTD PMID:10082212 (-)-lobeline multiple interactions ISO RGD:736847 6480464 Lobeline binds to and results in decreased activity of CHRNA7 protein, Lobeline binds to and results in increased activity of CHRNA7 protein mutant form CTD PMID:10082212 (R)-adrenaline multiple interactions ISO RGD:736847 6480464 [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased abundance of Epinephrine] CTD PMID:17498763 (S)-nicotine affects response to substance EXP 6480464 CHRNA7 gene polymorphism affects the susceptibility to Nicotine, CHRNA7 protein affects the susceptibility to Nicotine CTD PMID:10942032 more ... (S)-nicotine affects activity ISO RGD:736847 6480464 Nicotine affects the activity of CHRNA7 protein CTD PMID:29248576 (S)-nicotine increases response to substance ISO RGD:736847 6480464 CHRNA7 protein mutant form results in increased susceptibility to Nicotine CTD PMID:10082212 (S)-nicotine increases activity ISO RGD:736847 6480464 Nicotine results in increased activity of CHRNA7 protein CTD PMID:10082212 more ... (S)-nicotine decreases expression ISO RGD:736847 6480464 Nicotine results in decreased expression of CHRNA7 mRNA CTD PMID:12628473 (S)-nicotine increases expression ISO RGD:736847 6480464 Nicotine results in increased expression of CHRNA7 more ... CTD PMID:10216184 more ... (S)-nicotine multiple interactions ISO RGD:736847 6480464 1 more ... CTD PMID:10216184 more ... (S)-nicotine decreases expression ISO RGD:2348 6480464 Nicotine results in decreased expression of CHRNA7 mRNA, Nicotine results in decreased expression of CHRNA7 protein CTD PMID:20060465 , PMID:27329243 (S)-nicotine increases activity ISO RGD:2348 6480464 Nicotine results in increased activity of CHRNA7 protein CTD PMID:17241116 more ... (S)-nicotine multiple interactions ISO RGD:2348 6480464 [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] which affects the susceptibility to Nicotine more ... CTD PMID:17218065 more ... (S)-nicotine increases expression EXP 6480464 Nicotine results in increased expression of CHRNA7 mRNA, Nicotine results in increased expression of CHRNA7 protein CTD PMID:14500745 more ... (S)-nicotine increases response to substance EXP 6480464 CHRNA7 protein mutant form results in increased susceptibility to Nicotine CTD PMID:11854451 (S)-nicotine multiple interactions EXP 6480464 [Bungarotoxins results in decreased activity of CHRNA7 protein] which results in decreased susceptibility to Nicotine more ... CTD PMID:11893908 , PMID:24380835 1,1-dimethyl-4-phenylpiperazinium iodide multiple interactions ISO RGD:736847 6480464 Dimethylphenylpiperazinium Iodide inhibits the reaction [Bungarotoxins binds to CHRNA7 protein] CTD PMID:10216184 1,1-dimethyl-4-phenylpiperazinium iodide increases activity ISO RGD:736847 6480464 Dimethylphenylpiperazinium Iodide results in increased activity of CHRNA7 protein CTD PMID:10082212 1,1-dimethyl-4-phenylpiperazinium iodide increases response to substance ISO RGD:736847 6480464 CHRNA7 protein mutant form results in increased susceptibility to Dimethylphenylpiperazinium Iodide CTD PMID:10082212 13-desmethylspirolide C multiple interactions ISO RGD:736847 6480464 13-desmethylspirolide C binds to and results in decreased activity of CHRNA7 protein CTD PMID:26063663 17alpha-ethynylestradiol increases expression ISO RGD:2348 6480464 Ethinyl Estradiol results in increased expression of CHRNA7 mRNA CTD PMID:29097150 17beta-estradiol increases expression ISO RGD:2348 6480464 Estradiol results in increased expression of CHRNA7 protein CTD PMID:21092740 17beta-estradiol multiple interactions ISO RGD:2348 6480464 [bisphenol A co-treated with Estradiol] results in increased expression of CHRNA7 mRNA CTD PMID:26496021 3,4-methylenedioxymethamphetamine multiple interactions ISO RGD:736847 6480464 1-(5-chloro-2 more ... CTD PMID:20132834 3,4-methylenedioxymethamphetamine increases activity ISO RGD:736847 6480464 N-Methyl-3, 4-methylenedioxyamphetamine results in increased activity of CHRNA7 protein CTD PMID:20132834 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one increases activity ISO RGD:736847 6480464 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased activity of CHRNA7 protein CTD PMID:19027725 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one affects binding ISO RGD:736847 6480464 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone binds to CHRNA7 protein CTD PMID:16835749 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one increases expression ISO RGD:736847 6480464 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of CHRNA7 protein CTD PMID:17459420 5-hydroxyindole multiple interactions ISO RGD:2348 6480464 5-hydroxyindole binds to and results in increased activity of CHRNA7 protein more ... CTD PMID:18321476 6-propyl-2-thiouracil increases expression ISO RGD:2348 6480464 Propylthiouracil results in increased expression of CHRNA7 mRNA CTD PMID:24780913 acetylcholine increases response to substance ISO RGD:736847 6480464 CHRNA7 protein mutant form results in increased susceptibility to Acetylcholine CTD PMID:10082212 acetylcholine increases activity ISO RGD:736847 6480464 Acetylcholine results in increased activity of CHRNA7 protein CTD PMID:10082212 more ... acetylcholine increases activity ISO RGD:2348 6480464 Acetylcholine results in increased activity of CHRNA7 protein CTD PMID:15885267 more ... acetylcholine multiple interactions ISO RGD:2348 6480464 1 more ... CTD PMID:15885267 more ... acetylcholine multiple interactions ISO RGD:736847 6480464 1-(5-chloro-2 more ... CTD PMID:12626641 more ... aflatoxin B1 decreases expression ISO RGD:2348 6480464 Aflatoxin B1 results in decreased expression of CHRNA7 mRNA CTD PMID:26260870 aflatoxin B1 decreases methylation ISO RGD:736847 6480464 Aflatoxin B1 results in decreased methylation of CHRNA7 gene CTD PMID:27153756 all-trans-retinoic acid increases expression EXP 6480464 Tretinoin results in increased expression of CHRNA7 protein CTD PMID:17203487 ammonium chloride affects expression ISO RGD:2348 6480464 Ammonium Chloride affects the expression of CHRNA7 mRNA CTD PMID:16483693 Anabaseine multiple interactions ISO RGD:2348 6480464 anabaseine inhibits the reaction [iodo-alpha-bungarotoxin binds to CHRNA7 protein] CTD PMID:19448648 Anatoxin a multiple interactions ISO RGD:2348 6480464 anatoxin a inhibits the reaction [iodo-alpha-bungarotoxin binds to CHRNA7 protein] CTD PMID:19448648 atracurium multiple interactions ISO RGD:736847 6480464 Atracurium inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein] CTD PMID:16931985 bisphenol A multiple interactions ISO RGD:2348 6480464 [bisphenol A co-treated with Estradiol] results in increased expression of CHRNA7 mRNA, [bisphenol A co-treated with Testosterone] results in increased expression of CHRNA7 mRNA CTD PMID:26496021 bisphenol A decreases expression ISO RGD:2348 6480464 bisphenol A results in decreased expression of CHRNA7 mRNA CTD PMID:25181051 butanal increases expression ISO RGD:736847 6480464 butyraldehyde results in increased expression of CHRNA7 mRNA CTD PMID:26079696 calcium atom multiple interactions ISO RGD:736847 6480464 [[1-(5-chloro-2 more ... CTD PMID:17709503 more ... calcium atom multiple interactions ISO RGD:2348 6480464 [Nicotine results in increased activity of CHRNA7 protein] which results in increased transport of Calcium CTD PMID:17709503 calcium(0) multiple interactions ISO RGD:736847 6480464 [[1-(5-chloro-2 more ... CTD PMID:17709503 more ... calcium(0) multiple interactions ISO RGD:2348 6480464 [Nicotine results in increased activity of CHRNA7 protein] which results in increased transport of Calcium CTD PMID:17709503 carbachol multiple interactions ISO RGD:736847 6480464 1-(5-chloro-2 more ... CTD PMID:10216184 more ... carbachol affects activity ISO RGD:736847 6480464 Carbachol affects the activity of CHRNA7 protein CTD PMID:29248576 carbachol multiple interactions ISO RGD:2348 6480464 Carbachol affects the reaction [iodo-alpha-bungarotoxin binds to CHRNA7 protein] CTD PMID:19448648 carbon nanotube increases expression EXP 6480464 Nanotubes, Carbon analog results in increased expression of CHRNA7 mRNA, Nanotubes, Carbon results in increased expression of CHRNA7 mRNA CTD PMID:25554681 chlorpyrifos decreases expression ISO RGD:2348 6480464 Chlorpyrifos results in decreased expression of CHRNA7 mRNA CTD PMID:17452286 chlorpyrifos multiple interactions EXP 6480464 CHRNA7 protein affects the reaction [Chlorpyrifos results in increased expression of ACHE mRNA alternative form] CTD PMID:27163631 chlorpyrifos decreases expression EXP 6480464 Chlorpyrifos results in decreased expression of CHRNA7 mRNA CTD PMID:27163631 , PMID:30278244 chlorpyrifos affects expression ISO RGD:2348 6480464 Chlorpyrifos affects the expression of CHRNA7 mRNA CTD PMID:18977431 choline multiple interactions ISO RGD:736847 6480464 ACHE protein alternative form inhibits the reaction [Choline binds to CHRNA7 protein] more ... CTD PMID:12626641 more ... choline multiple interactions ISO RGD:2348 6480464 Choline affects the reaction [iodo-alpha-bungarotoxin binds to CHRNA7 protein] CTD PMID:19448648 choline increases activity ISO RGD:736847 6480464 Choline results in increased activity of CHRNA7 protein CTD PMID:10082212 , PMID:28395994 choline increases response to substance ISO RGD:736847 6480464 CHRNA7 protein mutant form results in increased susceptibility to Choline CTD PMID:10082212 choline multiple interactions EXP 6480464 Choline binds to and results in increased activity of CHRNA7 protein CTD PMID:19498423 choline affects binding ISO RGD:736847 6480464 Choline binds to CHRNA7 protein CTD PMID:19287501 cisatracurium multiple interactions ISO RGD:736847 6480464 cisatracurium inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein] CTD PMID:16931985 cisplatin increases expression ISO RGD:736847 6480464 Cisplatin results in increased expression of CHRNA7 mRNA CTD PMID:27392435 Citreoviridin decreases expression EXP 6480464 citreoviridin results in decreased expression of CHRNA7 mRNA CTD PMID:30071239 cytisine multiple interactions ISO RGD:736847 6480464 cytisine inhibits the reaction [Bungarotoxins binds to CHRNA7 protein] CTD PMID:10216184 cytisine multiple interactions ISO RGD:2348 6480464 cytisine inhibits the reaction [iodo-alpha-bungarotoxin binds to CHRNA7 protein] CTD PMID:19448648 dextran sulfate multiple interactions EXP 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of CHRNA7 mRNA CTD PMID:29950665 diazinon affects expression ISO RGD:2348 6480464 Diazinon affects the expression of CHRNA7 mRNA CTD PMID:18812211 diazinon decreases expression ISO RGD:2348 6480464 Diazinon results in decreased expression of CHRNA7 mRNA CTD PMID:17452286 dieldrin increases expression ISO RGD:2348 6480464 Dieldrin results in increased expression of CHRNA7 mRNA CTD PMID:18812211 dihydro-beta-erythroidine increases activity ISO RGD:736847 6480464 Dihydro-beta-Erythroidine results in increased activity of CHRNA7 protein mutant form CTD PMID:10082212 dihydro-beta-erythroidine multiple interactions ISO RGD:2348 6480464 Dihydro-beta-Erythroidine affects the reaction [iodo-alpha-bungarotoxin binds to CHRNA7 protein] CTD PMID:19448648 dihydro-beta-erythroidine affects response to substance ISO RGD:736847 6480464 CHRNA7 protein mutant form affects the susceptibility to Dihydro-beta-Erythroidine CTD PMID:10082212 dihydro-beta-erythroidine multiple interactions ISO RGD:736847 6480464 Dihydro-beta-Erythroidine binds to and results in decreased activity of CHRNA7 protein CTD PMID:10082212 Dinophysistoxin 1 increases expression ISO RGD:736847 6480464 dinophysistoxin 1 results in increased expression of CHRNA7 mRNA CTD PMID:28939011 dioxygen multiple interactions EXP 6480464 [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of CHRNA7 mRNA CTD PMID:30529165 doxorubicin decreases expression ISO RGD:736847 6480464 Doxorubicin results in decreased expression of CHRNA7 mRNA CTD PMID:29803840 epibatidine multiple interactions ISO RGD:2348 6480464 epibatidine inhibits the reaction [iodo-alpha-bungarotoxin binds to CHRNA7 protein] CTD PMID:19448648 epibatidine affects activity ISO RGD:736847 6480464 epibatidine affects the activity of CHRNA7 protein CTD PMID:29248576 epibatidine multiple interactions ISO RGD:736847 6480464 1-(5-chloro-2 more ... CTD PMID:21703337 , PMID:29248576 epibatidine affects binding ISO RGD:736847 6480464 epibatidine binds to CHRNA7 protein CTD PMID:21703337 ethanol decreases expression ISO RGD:2348 6480464 Ethanol results in decreased expression of CHRNA7 mRNA CTD PMID:15353170 ethanol affects expression EXP 6480464 Ethanol affects the expression of CHRNA7 mRNA CTD PMID:30319688 galanthamine multiple interactions EXP 6480464 Galantamine inhibits the reaction [APP protein modified form results in decreased expression of CHRNA7 protein], methyllycaconitine inhibits the reaction [Galantamine inhibits the reaction [APP protein modified form results in decreased expression of CHRNA7 protein]] CTD PMID:25881725 galanthamine Trifluoroacetic acid multiple interactions EXP 6480464 Galantamine inhibits the reaction [APP protein modified form results in decreased expression of CHRNA7 protein], methyllycaconitine inhibits the reaction [Galantamine inhibits the reaction [APP protein modified form results in decreased expression of CHRNA7 protein]] CTD PMID:25881725 GW 4064 decreases expression EXP 6480464 GW 4064 results in decreased expression of CHRNA7 mRNA CTD PMID:26655953 LY294002 multiple interactions ISO RGD:736847 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[PNU-282987 binds to and results in increased activity of CHRNA7 protein] which results in decreased susceptibility to Okadaic Acid] CTD PMID:21715663 manganese(II) chloride decreases expression EXP 6480464 manganese chloride results in decreased expression of CHRNA7 protein CTD PMID:25874029 Mecamylamine multiple interactions ISO RGD:736847 6480464 Mecamylamine binds to and results in decreased activity of CHRNA7 protein more ... CTD PMID:10082212 , PMID:21715663 melittin multiple interactions ISO RGD:2348 6480464 Bungarotoxins inhibits the reaction [Melitten results in increased activity of CHRNA7 protein], methyllycaconitine inhibits the reaction [Melitten results in increased activity of CHRNA7 protein] CTD PMID:19910175 melittin increases activity ISO RGD:2348 6480464 Melitten results in increased activity of CHRNA7 protein CTD PMID:19910175 methyllycaconitine multiple interactions EXP 6480464 [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] which results in decreased susceptibility to Nicotine more ... CTD PMID:11893908 more ... methyllycaconitine affects response to substance EXP 6480464 CHRNA7 protein affects the susceptibility to methyllycaconitine CTD PMID:19098233 methyllycaconitine affects binding ISO RGD:2348 6480464 methyllycaconitine analog binds to CHRNA7 protein, methyllycaconitine binds to CHRNA7 protein CTD PMID:17098430 , PMID:17218065 methyllycaconitine multiple interactions ISO RGD:736847 6480464 [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased abundance of Epinephrine] more ... CTD PMID:10082212 more ... methyllycaconitine multiple interactions ISO RGD:2348 6480464 [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] which affects the susceptibility to Nicotine more ... CTD PMID:15523001 more ... Mivacurium multiple interactions ISO RGD:736847 6480464 mivacurium inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein] CTD PMID:16931985 N-butyl-N-(4-hydroxybutyl)nitrosamine multiple interactions ISO RGD:2348 6480464 [Nicotine co-treated with Butylhydroxybutylnitrosamine] results in increased expression of CHRNA7 protein CTD PMID:29501575 N-nitrosodiethylamine increases expression ISO RGD:2348 6480464 Diethylnitrosamine results in increased expression of CHRNA7 mRNA CTD PMID:20360939 nickel atom decreases expression ISO RGD:2348 6480464 Nickel results in decreased expression of CHRNA7 mRNA CTD PMID:18812211 nicotine affects response to substance EXP 6480464 CHRNA7 gene polymorphism affects the susceptibility to Nicotine, CHRNA7 protein affects the susceptibility to Nicotine CTD PMID:10942032 more ... nicotine affects activity ISO RGD:736847 6480464 Nicotine affects the activity of CHRNA7 protein CTD PMID:29248576 nicotine increases response to substance ISO RGD:736847 6480464 CHRNA7 protein mutant form results in increased susceptibility to Nicotine CTD PMID:10082212 nicotine increases activity ISO RGD:736847 6480464 Nicotine results in increased activity of CHRNA7 protein CTD PMID:10082212 more ... nicotine decreases expression ISO RGD:736847 6480464 Nicotine results in decreased expression of CHRNA7 mRNA CTD PMID:12628473 nicotine increases expression ISO RGD:736847 6480464 Nicotine results in increased expression of CHRNA7 more ... CTD PMID:10216184 more ... nicotine multiple interactions ISO RGD:736847 6480464 1 more ... CTD PMID:10216184 more ... nicotine increases activity ISO RGD:2348 6480464 Nicotine results in increased activity of CHRNA7 protein CTD PMID:17241116 more ... nicotine decreases expression ISO RGD:2348 6480464 Nicotine results in decreased expression of CHRNA7 mRNA, Nicotine results in decreased expression of CHRNA7 protein CTD PMID:20060465 , PMID:27329243 nicotine multiple interactions ISO RGD:2348 6480464 [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] which affects the susceptibility to Nicotine more ... CTD PMID:17218065 more ... nicotine increases expression EXP 6480464 Nicotine results in increased expression of CHRNA7 mRNA, Nicotine results in increased expression of CHRNA7 protein CTD PMID:14500745 more ... nicotine increases response to substance EXP 6480464 CHRNA7 protein mutant form results in increased susceptibility to Nicotine CTD PMID:11854451 nicotine multiple interactions EXP 6480464 [Bungarotoxins results in decreased activity of CHRNA7 protein] which results in decreased susceptibility to Nicotine more ... CTD PMID:11893908 , PMID:24380835 okadaic acid multiple interactions ISO RGD:736847 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[PNU-282987 binds to and results in increased activity of CHRNA7 protein] which results in decreased susceptibility to Okadaic Acid] more ... CTD PMID:21715663 ozone multiple interactions EXP 6480464 [NOTCH3 gene mutant form affects the susceptibility to Ozone] which affects the expression of CHRNA7 mRNA CTD PMID:25658374 pancuronium multiple interactions ISO RGD:736847 6480464 Pancuronium inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein] CTD PMID:16931985 paracetamol increases expression ISO RGD:736847 6480464 Acetaminophen results in increased expression of CHRNA7 mRNA CTD PMID:29067470 paraquat increases expression ISO RGD:2348 6480464 Paraquat results in increased expression of CHRNA7 mRNA CTD PMID:18198484 parathion-methyl affects expression ISO RGD:2348 6480464 Methyl Parathion affects the expression of CHRNA7 mRNA CTD PMID:18977431 potassium dichromate decreases expression EXP 6480464 Potassium Dichromate results in decreased expression of CHRNA7 mRNA CTD PMID:23608068 propanal increases expression ISO RGD:736847 6480464 propionaldehyde results in increased expression of CHRNA7 mRNA CTD PMID:26079696 rocuronium multiple interactions ISO RGD:736847 6480464 rocuronium inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein] CTD PMID:16931985 sodium arsenite affects methylation ISO RGD:736847 6480464 sodium arsenite affects the methylation of CHRNA7 gene CTD PMID:28589171 sodium fluoride decreases expression ISO RGD:2348 6480464 Sodium Fluoride results in decreased expression of CHRNA7 protein CTD PMID:19900517 suramin increases expression EXP 6480464 Suramin results in increased expression of CHRNA7 protein CTD PMID:23516405 testosterone multiple interactions ISO RGD:2348 6480464 [bisphenol A co-treated with Testosterone] results in increased expression of CHRNA7 mRNA CTD PMID:26496021 tetrachloroethene multiple interactions ISO RGD:736847 6480464 Tetrachloroethylene inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein] CTD PMID:15885267 tetrachloroethene multiple interactions ISO RGD:2348 6480464 Tetrachloroethylene inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein] CTD PMID:15885267 tetrodotoxin multiple interactions ISO RGD:2348 6480464 Tetrodotoxin inhibits the reaction [[3-(4-hydroxy-2-methoxybenzylidene)anabaseine co-treated with 5-hydroxyindole] results in increased activity of CHRNA7 protein] CTD PMID:18321476 titanium dioxide multiple interactions EXP 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of CHRNA7 mRNA CTD PMID:29950665 toluene multiple interactions ISO RGD:2348 6480464 Toluene inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein] CTD PMID:15885267 toluene multiple interactions ISO RGD:736847 6480464 Toluene inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein] CTD PMID:15885267 topiramate decreases expression ISO RGD:2348 6480464 topiramate results in decreased expression of CHRNA7 mRNA CTD PMID:16979414 tubocurarine multiple interactions ISO RGD:736847 6480464 Tubocurarine binds to and results in decreased activity of CHRNA7 protein more ... CTD PMID:10082212 more ... urethane increases expression ISO RGD:736847 6480464 Urethane results in increased expression of CHRNA7 mRNA CTD PMID:28818685 varenicline multiple interactions ISO RGD:2348 6480464 Varenicline binds to and results in increased activity of [CHRNA7 protein binds to CHRNA7 protein] CTD PMID:16766716 vecuronium bromide multiple interactions ISO RGD:736847 6480464 Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein] CTD PMID:16931985
Biological Process acetylcholine receptor signaling pathway ISO RGD:2348 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 activation of MAPK activity ISO UniProtKB:P36544 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 associative learning IGI MGI:MGI:87891 2290270 (MGI:MGI:3513661, PMID:15541879) MGI MGI:MGI:3513661 , PMID:15541879 associative learning IMP MGI:MGI:1888407 2290270 (MGI:MGI:3580035, PMID:15922075) MGI MGI:MGI:3580035 , PMID:15922075 B cell activation IMP MGI:MGI:1888407 2290270 (MGI:MGI:3610855 more ... MGI MGI:MGI:3610855 more ... behavioral response to ethanol IMP MGI:MGI:1888407 2290270 (MGI:MGI:3511640, PMID:15489024) MGI MGI:MGI:3511640 , PMID:15489024 behavioral response to nicotine IGI MGI:MGI:87891 2290270 (MGI:MGI:3710706, PMID:17470777) MGI MGI:MGI:3710706 , PMID:17470777 calcium ion transport ISO UniProtKB:Q05941 2290270 MGI GO_REF:0000008, MGI:MGI:2154458 calcium ion transport ISO UniProtKB:P36544 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 cellular calcium ion homeostasis ISO UniProtKB:P36544 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 chemical synaptic transmission IBA FB:FBgn0003011 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 cognition ISO UniProtKB:P36544 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 dendrite arborization IMP 2290270 (MGI:MGI:5487905, PMID:23270857) ARUK-UCL MGI:MGI:5487905 , PMID:23270857 dendritic spine organization IMP 2290270 (MGI:MGI:5487905, PMID:23270857) ARUK-UCL MGI:MGI:5487905 , PMID:23270857 endocytosis IMP 2290270 (MGI:MGI:3604036, PMID:16025111) MGI MGI:MGI:3604036 , PMID:16025111 flagellated sperm motility IMP MGI:MGI:1888407 2290270 (MGI:MGI:3691713, PMID:15944242) MGI MGI:MGI:3691713 , PMID:15944242 generation of ovulation cycle rhythm IMP MGI:MGI:1888407 2290270 (MGI:MGI:3053480, PMID:15364017) MGI MGI:MGI:3053480 , PMID:15364017 ion transmembrane transport ISO UniProtKB:P36544 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 ion transmembrane transport IBA PANTHER:PTN000434994 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 ion transport IMP MGI:MGI:1888407 2290270 (MGI:MGI:1099674, PMID:9364063) MGI MGI:MGI:1099674 , PMID:9364063 ion transport IMP MGI:MGI:2155604 2290270 (MGI:MGI:1355142, PMID:10800961) MGI MGI:MGI:1355142 , PMID:10800961 learning or memory IGI UniProtKB:P05067 2290270 (MGI:MGI:4352762 more ... ARUK-UCL MGI:MGI:4352762 more ... learning or memory IGI ComplexPortal:CPX-1134, UniProtKB:P05067:PRO_0000000092 2290270 (MGI:MGI:5825427, PMID:19118188) ARUK-UCL MGI:MGI:5825427 , PMID:19118188 memory IMP MGI:MGI:1888407 2290270 (MGI:MGI:3718964, PMID:16923147) MGI MGI:MGI:3718964 , PMID:16923147 memory ISO RGD:2348 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 modulation of chemical synaptic transmission IGI UniProtKB:P56818 2290270 (MGI:MGI:5819343, PMID:20943921) ARUK-UCL MGI:MGI:5819343 , PMID:20943921 modulation of excitatory postsynaptic potential IDA 2290270 (MGI:MGI:4889154, PMID:20974225) ARUK-UCL MGI:MGI:4889154 , PMID:20974225 modulation of excitatory postsynaptic potential IGI UniProtKB:P05067 2290270 (MGI:MGI:4889154, PMID:20974225) ARUK-UCL MGI:MGI:4889154 , PMID:20974225 negative regulation of amyloid-beta formation ISO UniProtKB:P36544 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 negative regulation of ERK1 and ERK2 cascade ISO RGD:2348 2290270 MGI GO_REF:0000096, MGI:MGI:4417868 negative regulation of inflammatory response IMP MGI:MGI:1888407 2290270 (MGI:MGI:3721478, PMID:16785311) MGI MGI:MGI:3721478 , PMID:16785311 negative regulation of interleukin-1 beta production IMP MGI:MGI:1888407 2290270 (MGI:MGI:3040787, PMID:12508119) MGI MGI:MGI:3040787 , PMID:12508119 negative regulation of interleukin-6 production IMP MGI:MGI:1888407 2290270 (MGI:MGI:3040787, PMID:12508119) MGI MGI:MGI:3040787 , PMID:12508119 negative regulation of protein phosphorylation IDA 2290270 (MGI:MGI:3843740, PMID:19230830) ARUK-UCL MGI:MGI:3843740 , PMID:19230830 negative regulation of tumor necrosis factor production ISO UniProtKB:P36544 2290270 MGI GO_REF:0000008, MGI:MGI:2154458 negative regulation of tumor necrosis factor production IMP MGI:MGI:1888407 2290270 (MGI:MGI:3040787 more ... MGI MGI:MGI:3040787 more ... nervous system process IBA MGI:MGI:87888 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 neuronal action potential ISO RGD:2348 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 ovulation cycle IMP MGI:MGI:1888407 2290270 (MGI:MGI:3052645, PMID:1400473) MGI MGI:MGI:3052645 , PMID:1400473 positive regulation of acetylcholine biosynthetic process IC GO:0051247, GO:1905920 2290270 (MGI:MGI:4437154, PMID:20164328) ARUK-UCL MGI:MGI:4437154 , PMID:20164328 positive regulation of amyloid-beta formation IGI UniProtKB:P05067 2290270 (MGI:MGI:4437154, PMID:20164328) ARUK-UCL MGI:MGI:4437154 , PMID:20164328 positive regulation of angiogenesis ISO UniProtKB:P36544 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 positive regulation of cell population proliferation ISO UniProtKB:P36544 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 positive regulation of CoA-transferase activity IGI UniProtKB:P05067 2290270 (MGI:MGI:4437154, PMID:20164328) ARUK-UCL MGI:MGI:4437154 , PMID:20164328 positive regulation of ERK1 and ERK2 cascade IGI UniProtKB:P05067 2290270 (MGI:MGI:4437154, PMID:20164328) ARUK-UCL MGI:MGI:4437154 , PMID:20164328 positive regulation of ERK1 and ERK2 cascade IMP 2290270 (MGI:MGI:5825438, PMID:11404397) ARUK-UCL MGI:MGI:5825438 , PMID:11404397 positive regulation of ERK1 and ERK2 cascade ISO RGD:2348 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 positive regulation of ERK1 and ERK2 cascade IDA 2290270 (MGI:MGI:5819349, PMID:17898229) ARUK-UCL MGI:MGI:5819349 , PMID:17898229 positive regulation of excitatory postsynaptic potential IGI ComplexPortal:CPX-1134, UniProtKB:P05067:PRO_0000000092 2290270 (MGI:MGI:5825427, PMID:19118188) ARUK-UCL MGI:MGI:5825427 , PMID:19118188 positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure IMP MGI:MGI:1888407 2290270 (MGI:MGI:3531222, PMID:10942027) MGI MGI:MGI:3531222 , PMID:10942027 positive regulation of long-term synaptic potentiation IDA 2290270 (MGI:MGI:4889154, PMID:20974225) ARUK-UCL MGI:MGI:4889154 , PMID:20974225 positive regulation of long-term synaptic potentiation IGI ComplexPortal:CPX-1134, UniProtKB:P05067:PRO_0000000092 2290270 (MGI:MGI:5825427, PMID:19118188) ARUK-UCL MGI:MGI:5825427 , PMID:19118188 positive regulation of long-term synaptic potentiation IGI UniProtKB:P05067 2290270 (MGI:MGI:4889154, PMID:20974225) ARUK-UCL MGI:MGI:4889154 , PMID:20974225 positive regulation of peptidyl-serine phosphorylation IMP 2290270 (MGI:MGI:3843740, PMID:19230830) ARUK-UCL MGI:MGI:3843740 , PMID:19230830 positive regulation of protein metabolic process IGI UniProtKB:P05067 2290270 (MGI:MGI:4437154, PMID:20164328) ARUK-UCL MGI:MGI:4437154 , PMID:20164328 positive regulation of protein phosphorylation IDA 2290270 (MGI:MGI:5819349, PMID:17898229) ARUK-UCL MGI:MGI:5819349 , PMID:17898229 regulation of amyloid fibril formation IGI UniProtKB:P05067 2290270 (MGI:MGI:4437154, PMID:20164328) ARUK-UCL MGI:MGI:4437154 , PMID:20164328 regulation of amyloid precursor protein catabolic process ISO UniProtKB:P36544 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 regulation of inflammatory response IMP MGI:MGI:1888407 2290270 (MGI:MGI:3040787, PMID:12508119) MGI MGI:MGI:3040787 , PMID:12508119 regulation of membrane potential IMP MGI:MGI:1888407 2290270 (MGI:MGI:1099674, PMID:9364063) MGI MGI:MGI:1099674 , PMID:9364063 regulation of membrane potential IBA MGI:MGI:87885 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 regulation of membrane potential ISO UniProtKB:Q05941 2290270 MGI GO_REF:0000008, MGI:MGI:2154458 regulation of membrane potential IMP MGI:MGI:2155604 2290270 (MGI:MGI:1355142, PMID:10800961) MGI MGI:MGI:1355142 , PMID:10800961 regulation of neuron death IGI UniProtKB:P05067 2290270 (MGI:MGI:4437154, PMID:20164328) ARUK-UCL MGI:MGI:4437154 , PMID:20164328 regulation of norepinephrine secretion IMP MGI:MGI:1888407 2290270 (MGI:MGI:3531222, PMID:10942027) MGI MGI:MGI:3531222 , PMID:10942027 regulation of synapse structural plasticity IC GO:0051247 2290270 (MGI:MGI:4437154, PMID:20164328) ARUK-UCL MGI:MGI:4437154 , PMID:20164328 regulation of synaptic transmission, cholinergic IC GO:0051247 2290270 (MGI:MGI:4437154, PMID:20164328) ARUK-UCL MGI:MGI:4437154 , PMID:20164328 regulation of synaptic transmission, dopaminergic IMP MGI:MGI:1888407 2290270 (MGI:MGI:3716008, PMID:16772172) MGI MGI:MGI:3716008 , PMID:16772172 regulation of synaptic vesicle exocytosis ISO RGD:2348 2290270 MGI GO_REF:0000096, MGI:MGI:4417868 response to acetylcholine ISO RGD:2348 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 response to acetylcholine ISO UniProtKB:P36544 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 response to amyloid-beta IMP 2290270 (MGI:MGI:5825427, PMID:19118188) ARUK-UCL MGI:MGI:5825427 , PMID:19118188 response to cold IDA 2290270 (MGI:MGI:3843740, PMID:19230830) ARUK-UCL MGI:MGI:3843740 , PMID:19230830 response to ethanol IMP MGI:MGI:1888407 2290270 (MGI:MGI:3612839, PMID:15555774) MGI MGI:MGI:3612839 , PMID:15555774 response to food IMP MGI:MGI:1888407 2290270 (MGI:MGI:3580035, PMID:15922075) MGI MGI:MGI:3580035 , PMID:15922075 response to hypoxia ISO UniProtKB:P36544 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 response to nicotine IMP 2290270 (MGI:MGI:1202051, PMID:9495872) MGI MGI:MGI:1202051 , PMID:9495872 response to nicotine IGI UniProtKB:P63085 2290270 (MGI:MGI:5825438, PMID:11404397) ARUK-UCL MGI:MGI:5825438 , PMID:11404397 response to nicotine ISO RGD:2348 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 response to nicotine ISO UniProtKB:P36544 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 response to nicotine IMP MGI:MGI:1888407 2290270 (MGI:MGI:3710894, PMID:17291692) MGI MGI:MGI:3710894 , PMID:17291692 sensory processing IDA 2290270 (MGI:MGI:5819349, PMID:17898229) ARUK-UCL MGI:MGI:5819349 , PMID:17898229 sensory processing ISO RGD:2348 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 signal transduction ISO UniProtKB:P36544 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 signal transduction IBA PANTHER:PTN000434994 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 synapse organization IGI UniProtKB:P05067 2290270 (MGI:MGI:4352762, PMID:19587288) ARUK-UCL MGI:MGI:4352762 , PMID:19587288 synaptic transmission, cholinergic IMP MGI:MGI:1888407 2290270 (MGI:MGI:1099674, PMID:9364063) MGI MGI:MGI:1099674 , PMID:9364063 synaptic transmission, cholinergic IBA MGI:MGI:99779 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 synaptic transmission, cholinergic ISO RGD:2348 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 T cell activation IMP MGI:MGI:1888407 2290270 (MGI:MGI:3663537, PMID:16253349) MGI MGI:MGI:3663537 , PMID:16253349 Cellular Component acetylcholine-gated channel complex ISO RGD:2348 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 acetylcholine-gated channel complex IBA PANTHER:PTN001450553 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 acetylcholine-gated channel complex ISO UniProtKB:P36544 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 apical plasma membrane IDA 2290270 (MGI:MGI:3603731, PMID:16033766) MGI MGI:MGI:3603731 , PMID:16033766 asymmetric synapse ISO RGD:2348 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 axolemma IDA 2290270 (MGI:MGI:3796800, PMID:18458158) MGI MGI:MGI:3796800 , PMID:18458158 axon ISO RGD:2348 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 cell junction IEA UniProtKB-KW:KW-0965 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 cholinergic synapse ISO RGD:2348 2290270 MGI GO_REF:0000096, MGI:MGI:4417868 cholinergic synapse IDA 2290270 (MGI:MGI:6189620, PMID:12079404) SynGO MGI:MGI:6189620 , PMID:12079404 cytoplasm ISO RGD:2348 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 dendrite ISO RGD:2348 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 dendritic shaft ISO RGD:2348 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 dendritic spine ISO RGD:2348 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 external side of plasma membrane IDA 2290270 (MGI:MGI:3610855, PMID:15963492) MGI MGI:MGI:3610855 , PMID:15963492 glycinergic synapse ISO RGD:2348 2290270 MGI GO_REF:0000096, MGI:MGI:4417868 growth cone ISO RGD:2348 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 integral component of membrane IEA UniProtKB-KW:KW-0812 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 integral component of membrane IEA InterPro:IPR002394 more ... 2290270 UniProtKB GO_REF:0000002, MGI:MGI:2152098 integral component of plasma membrane IBA MGI:MGI:1861899 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 integral component of postsynaptic membrane IDA 2290270 (MGI:MGI:5577205, PMID:24607281) SynGO MGI:MGI:5577205 , PMID:24607281 integral component of postsynaptic membrane ISO RGD:2348 2290270 MGI GO_REF:0000096, MGI:MGI:4417868 integral component of postsynaptic specialization membrane IDA 2290270 (MGI:MGI:6189620, PMID:12079404) MGI MGI:MGI:6189620 , PMID:12079404 integral component of postsynaptic specialization membrane ISO RGD:2348 2290270 MGI GO_REF:0000096, MGI:MGI:4417868 integral component of presynaptic membrane IDA 2290270 (MGI:MGI:5577205, PMID:24607281) MGI MGI:MGI:5577205 , PMID:24607281 integral component of presynaptic membrane ISO RGD:2348 2290270 MGI GO_REF:0000096, MGI:MGI:4417868 integral component of spine apparatus membrane ISO RGD:2348 2290270 MGI GO_REF:0000096, MGI:MGI:4417868 membrane IDA 2290270 (MGI:MGI:2158987 more ... MGI MGI:MGI:2158987 more ... membrane raft ISO RGD:2348 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 neuron projection IBA MGI:MGI:95747 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 neuronal cell body ISO RGD:2348 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 plasma membrane ISO UniProtKB:P36544 2290270 MGI GO_REF:0000008, MGI:MGI:2154458 plasma membrane ISO RGD:2348 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 plasma membrane raft ISO RGD:2348 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 postsynaptic density ISO RGD:2348 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 postsynaptic membrane IEA InterPro:IPR002394 2290270 UniProtKB GO_REF:0000002, MGI:MGI:2152098 postsynaptic membrane IEA UniProtKB-KW:KW-0628 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 presynapse TAS 2290270 (MGI:MGI:5825427, PMID:19118188) ARUK-UCL MGI:MGI:5825427 , PMID:19118188 presynaptic membrane ISO RGD:2348 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 synapse IBA MGI:MGI:95747 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 Molecular Function acetylcholine binding ISO UniProtKB:P36544 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 acetylcholine binding IBA PANTHER:PTN001450553 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 acetylcholine binding ISO RGD:2348 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 acetylcholine receptor activity ISO UniProtKB:P36544 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 acetylcholine receptor activity contributes_to IBA PANTHER:PTN001450553 , UniProtKB:P36544 2290270 (PMID:21873635) GO_Central PMID:21873635 acetylcholine-gated cation-selective channel activity ISO RGD:2348 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 acetylcholine-gated cation-selective channel activity IMP 2290270 (MGI:MGI:85056, PMID:9037516) MGI MGI:MGI:85056 , PMID:9037516 acetylcholine-gated cation-selective channel activity IDA 2290270 (MGI:MGI:1202051, PMID:9495872) MGI MGI:MGI:1202051 , PMID:9495872 acetylcholine-gated cation-selective channel activity IMP MGI:MGI:1888407 2290270 (MGI:MGI:1099674 more ... MGI MGI:MGI:1099674 more ... acetylcholine-gated cation-selective channel activity ISO UniProtKB:P36544 2290270 MGI GO_REF:0000008, MGI:MGI:2154458 acetylcholine-gated cation-selective channel activity ISO UniProtKB:Q05941 2290270 MGI GO_REF:0000008, MGI:MGI:2154458 adenylate cyclase binding ISO RGD:2348 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 amyloid-beta binding ISO UniProtKB:P36544 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 ATPase binding ISO RGD:2348 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 chloride channel regulator activity ISO UniProtKB:P36544 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 drug binding ISO RGD:2348 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 extracellular ligand-gated ion channel activity contributes_to IBA PANTHER:PTN000434994 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 ion channel activity ISO UniProtKB:P36544 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 protein binding IPI UniProtKB:Q9WVC2 2290270 (MGI:MGI:2176631, PMID:11906696) MGI MGI:MGI:2176631 , PMID:11906696 protein binding IPI UniProtKB:Q8BLC3 2290270 (MGI:MGI:3838433, PMID:19246390) MGI MGI:MGI:3838433 , PMID:19246390 protein homodimerization activity ISO UniProtKB:P36544 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 protein kinase binding ISO RGD:2348 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 scaffold protein binding ISO RGD:2348 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 toxic substance binding ISO UniProtKB:P36544 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 transmembrane signaling receptor activity IEA InterPro:IPR006201 2290270 UniProtKB GO_REF:0000002, MGI:MGI:2152098 transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential ISO RGD:2348 2290270 MGI GO_REF:0000096, MGI:MGI:4417868
Gene-Chemical Interaction Annotations
