Hnmt (histamine N-methyltransferase) - Rat Genome Database

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Gene: Hnmt (histamine N-methyltransferase) Mus musculus
Analyze
Symbol: Hnmt
Name: histamine N-methyltransferase
RGD ID: 733645
MGI Page MGI
Description: Enables N-methyltransferase activity. Predicted to be involved in S-adenosylmethionine metabolic process; histamine catabolic process; and methylation. Predicted to be located in centrosome; cytosol; and nucleoplasm. Human ortholog(s) of this gene implicated in Parkinson's disease; asthma; atopic dermatitis; autosomal recessive intellectual developmental disorder 51; and essential tremor. Orthologous to human HNMT (histamine N-methyltransferase).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 1500031F01Rik; AI788969; HMT
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39223,892,923 - 23,939,756 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl223,892,922 - 23,939,406 (-)EnsemblGRCm39 Ensembl
GRCm38224,002,911 - 24,049,758 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl224,002,910 - 24,049,394 (-)EnsemblGRCm38mm10GRCm38
MGSCv37223,858,431 - 23,904,899 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36223,824,929 - 23,871,385 (-)NCBIMGSCv36mm8
Celera223,732,675 - 23,779,256 (-)NCBICelera
Cytogenetic Map2A3NCBI
cM Map216.06NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (EXP)
acetylsalicylic acid  (ISO)
acrylamide  (EXP)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
AM-251  (ISO)
ammonium chloride  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (EXP,ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (ISO)
Bisphenol B  (ISO)
butanal  (ISO)
cadmium dichloride  (ISO)
caspofungin  (ISO)
CGP 52608  (ISO)
chlordecone  (EXP)
chlorpyrifos  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (EXP)
cyclosporin A  (EXP,ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (EXP)
dicrotophos  (ISO)
dioxygen  (EXP)
dorsomorphin  (ISO)
elemental selenium  (ISO)
flavonoids  (ISO)
folic acid  (EXP)
furan  (ISO)
GW 4064  (EXP)
Heliotrine  (ISO)
histamine  (ISO)
indometacin  (ISO)
inulin  (EXP)
L-methionine  (ISO)
lipopolysaccharide  (ISO)
malathion  (ISO)
maneb  (EXP)
menadione  (ISO)
mercury dibromide  (ISO)
methylmercury chloride  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-nitrosodiethylamine  (ISO)
nicardipine  (ISO)
nickel atom  (ISO)
nifedipine  (ISO)
O-methyleugenol  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
pentanal  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP,ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP)
propiconazole  (EXP)
quercetin  (ISO)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
senecionine  (ISO)
Senkirkine  (ISO)
silicon dioxide  (ISO)
sunitinib  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
tetraphene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
Triptolide  (EXP)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (EXP)
vitamin E  (ISO)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
centrosome  (ISO)
cytoplasm  (ISO)
cytosol  (ISO)
nucleoplasm  (ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Reduction of the infarct size by simultaneous administration of L-histidine and diphenhydramine in ischaemic rat brains. Adachi N, etal., Resuscitation. 2011 Feb;82(2):219-21. Epub 2010 Dec 4.
2. Nonsynonymous polymorphisms of histamine-metabolising enzymes in patients with Parkinson's disease. Agundez JA, etal., Neuromolecular Med. 2008;10(1):10-6. Epub 2007 Nov 6.
3. No association of histamine- N-methyltransferase polymorphism with asthma or bronchial hyperresponsiveness in two German pediatric populations. Deindl P, etal., Pediatr Allergy Immunol. 2005 Feb;16(1):40-2.
4. Polymorphisms of histamine-metabolizing enzymes and clinical manifestations of asthma and allergic rhinitis. Garcia-Martin E, etal., Clin Exp Allergy. 2007 Aug;37(8):1175-82.
5. Variability of the L-Histidine decarboxylase gene in allergic rhinitis. Gervasini G, etal., Allergy. 2010 Dec;65(12):1576-84. doi: 10.1111/j.1398-9995.2010.02425.x.
6. Histamine N-methyltransferase Thr105Ile is not associated with Parkinson's disease or essential tremor. Keeling BH, etal., Parkinsonism Relat Disord. 2010 Feb;16(2):112-4. Epub 2009 Sep 20.
7. Association of the histamine N-methyltransferase C314T (Thr105Ile) polymorphism with atopic dermatitis in Caucasian children. Kennedy MJ, etal., Pharmacotherapy. 2008 Dec;28(12):1495-501.
8. Human brain cytosolic histamine-N-methyltransferase is decreased in Down syndrome and increased in Pick's disease. Kim SH, etal., Neurosci Lett. 2002 Mar 22;321(3):169-72.
9. The nonsynonymous Thr105Ile polymorphism of the histamine N-methyltransferase is associated to the risk of developing essential tremor. Ledesma MC, etal., Neuromolecular Med. 2008;10(4):356-61. Epub 2008 Jun 10.
10. No association between histamine N-methyltransferase functional polymorphism Thr105Ile and Alzheimer's disease. Marasovic-Susnjara I, etal., Neurosci Lett. 2011 Feb 4;489(2):119-21. Epub 2010 Dec 5.
11. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
12. MGDs mouse GO annotations MGD data from the GO Consortium
13. Reduction in brain infarction by augmentation of central histaminergic activity in rats. Motoki A, etal., Brain Res. 2005 Dec 20;1066(1-2):172-8. Epub 2005 Dec 5.
14. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
15. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
16. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. From model cell line to in vivo gene expression: disease-related intestinal gene expression in IBD. Schulze HA, etal., Genes Immun. 2008 Apr;9(3):240-8. Epub 2008 Mar 13.
20. Lack of association of histamine-N-methyltransferase (HNMT) polymorphisms with asthma in the Indian population. Sharma S, etal., J Hum Genet. 2005;50(12):611-7. Epub 2005 Oct 5.
21. Polymorphisms of two histamine-metabolizing enzymes genes and childhood allergic asthma: a case control study. Szczepankiewicz A, etal., Clin Mol Allergy. 2010 Nov 1;8:14.
22. Functional increase of brain histaminergic signaling in Huntington's disease. van Wamelen DJ, etal., Brain Pathol. 2011 Jul;21(4):419-27. doi: 10.1111/j.1750-3639.2010.00465.x. Epub 2010 Dec 27.
23. Histamine N-methyltransferase functional polymorphism: lack of association with schizophrenia. Yan L, etal., Am J Med Genet. 2000 Jun 12;96(3):404-6.
24. Histamine N-methyltransferase pharmacogenetics: association of a common functional polymorphism with asthma. Yan L, etal., Pharmacogenetics. 2000 Apr;10(3):261-6.
Additional References at PubMed
PMID:8605025   PMID:8889548   PMID:9547362   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11475331   PMID:11855681   PMID:12466851   PMID:12477932   PMID:14681479  
PMID:15489334   PMID:16141072   PMID:16141073   PMID:16602821   PMID:19162242   PMID:21267068   PMID:21677750   PMID:21873635   PMID:29162912   PMID:35487272   PMID:38002333  


Genomics

Comparative Map Data
Hnmt
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39223,892,923 - 23,939,756 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl223,892,922 - 23,939,406 (-)EnsemblGRCm39 Ensembl
GRCm38224,002,911 - 24,049,758 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl224,002,910 - 24,049,394 (-)EnsemblGRCm38mm10GRCm38
MGSCv37223,858,431 - 23,904,899 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36223,824,929 - 23,871,385 (-)NCBIMGSCv36mm8
Celera223,732,675 - 23,779,256 (-)NCBICelera
Cytogenetic Map2A3NCBI
cM Map216.06NCBI
HNMT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382137,964,473 - 138,016,364 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2137,964,020 - 138,016,364 (+)EnsemblGRCh38hg38GRCh38
GRCh372138,722,043 - 138,773,934 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362138,438,278 - 138,490,404 (+)NCBINCBI36Build 36hg18NCBI36
Build 342138,555,539 - 138,605,968NCBI
Celera2132,435,248 - 132,487,397 (+)NCBICelera
Cytogenetic Map2q22.1NCBI
HuRef2130,713,418 - 130,765,454 (+)NCBIHuRef
CHM1_12138,726,296 - 138,778,405 (+)NCBICHM1_1
T2T-CHM13v2.02138,410,245 - 138,462,150 (+)NCBIT2T-CHM13v2.0
Hnmt
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8326,978,274 - 27,010,291 (-)NCBIGRCr8
mRatBN7.236,591,804 - 6,623,821 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl36,591,463 - 6,624,012 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx39,674,061 - 9,706,077 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0318,260,252 - 18,292,268 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0316,450,071 - 16,482,087 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03905,111 - 937,038 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3904,765 - 937,102 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03896,736 - 928,663 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.432,057,938 - 2,089,955 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.132,057,591 - 2,090,146 (-)NCBI
Celera31,418,360 - 1,450,377 (-)NCBICelera
Cytogenetic Map3p13NCBI
Hnmt
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554405,084,081 - 5,139,348 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554405,084,198 - 5,137,577 (+)NCBIChiLan1.0ChiLan1.0
HNMT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21336,911,142 - 36,961,644 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B36,926,108 - 36,976,706 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B21,840,342 - 21,892,744 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B142,036,321 - 142,088,315 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B142,036,321 - 142,088,315 (+)Ensemblpanpan1.1panPan2
HNMT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11940,656,266 - 40,702,498 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1940,655,161 - 40,702,218 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1940,904,101 - 40,950,749 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01942,091,906 - 42,138,299 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1942,089,996 - 42,139,886 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11940,762,610 - 40,807,542 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01940,903,954 - 40,950,599 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01942,141,523 - 42,187,878 (+)NCBIUU_Cfam_GSD_1.0
Hnmt
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303103,451,547 - 103,494,746 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646938,122,454 - 38,166,398 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493646938,125,877 - 38,166,429 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HNMT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1513,732,680 - 13,768,199 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11513,733,412 - 13,768,106 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21516,061,749 - 16,096,444 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HNMT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11022,188,151 - 22,238,665 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1022,188,110 - 22,238,671 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040176,049,336 - 176,100,718 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hnmt
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473237,620,925 - 37,691,708 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473237,621,014 - 37,689,873 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Hnmt
1279 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:399
Count of miRNA genes:182
Interacting mature miRNAs:198
Transcripts:ENSMUST00000051416, ENSMUST00000114497, ENSMUST00000114498
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4141836Tgq11_mtriglyceride QTL 11 (mouse)Not determined125324559Mouse
4142333Tgq10_mtriglyceride QTL 10 (mouse)Not determined125324559Mouse
1301838Sluc16_msusceptibility to lung cancer 16 (mouse)Not determined2126529589Mouse
12904743Carcdq3_mcardiac collagen deposition QTL 3 (mouse)2323494028179150Mouse
1301769Orgwq2_morgan weight QTL 2 (mouse)Not determined2388712693421651Mouse
1301980Fcsa5_mfemoral cross-sectional area 5 (mouse)Not determined2767911541679261Mouse
1301790Pcfm1_mperiosteal circumference and femur length 1 (mouse)Not determined2823629642236396Mouse
10043876Adip22_madiposity 22 (mouse)Not determined2830805142308240Mouse
1300624Insq7_minsulin QTL 7 (mouse)Not determined2938444643384575Mouse
10755513Amzn4_manatomical modifier of Zfp423 4 (mouse)2938444643384575Mouse
12903993Opfaq1_mopen field activity QTL 1 (mouse)2967669127022642Mouse
8552707Cia23_mcollagen induced arthritis QTL 23 (mouse)Not determined21212953766556453Mouse
1301641Sbmd2_mspinal bone mineral density 2 (mouse)Not determined21421456748214713Mouse
1357881Estoq1_membryo survival total QTL 1 (mouse)Not determined220897778118894840Mouse
1357454Kidq1_mkidney weight QTL 1 (mouse)Not determined220897778118894840Mouse
1357436Splq1_mspleen weight QTL 1 (mouse)Not determined220897778118894840Mouse
39128209Lwq14_mliver weight QTL 14 (mouse)220897778118894840Mouse
1558899Egq1_mearly growth QTL 1 (mouse)Not determined220897778118894840Mouse
1558966W10q9_mweight 10 weeks QTL 9 (mouse)Not determined220897778118894840Mouse
1558915W3q1_mweight 3 weeks QTL 1 (mouse)Not determined220897778118894840Mouse
1558738W6q1_mweight 6 weeks QTL 1 (mouse)Not determined220897778118894840Mouse
1357681Hrtq1_mheart weight QTL 1 (mouse)Not determined220897778118894840Mouse
1301376Etohc1_methanol consumption 1 (mouse)Not determined22112972555129871Mouse
4141708Pbwg1.2_mpostnatal body weight growth 1.2 (mouse)Not determined2112972555129871Mouse
13463470Tubisq1_mtubulointerstitial injury severity, QTL 1 (mouse)22368914557689269Mouse

Markers in Region
AI788969  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38224,003,088 - 24,003,190UniSTSGRCm38
MGSCv37223,858,608 - 23,858,710UniSTSGRCm37
Celera223,732,852 - 23,732,954UniSTS
Cytogenetic Map2A3UniSTS
Whitehead/MRC_RH2412.02UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000051416   ⟹   ENSMUSP00000062747
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl223,892,922 - 23,939,406 (-)Ensembl
GRCm38.p6 Ensembl224,002,910 - 24,049,394 (-)Ensembl
RefSeq Acc Id: ENSMUST00000114497   ⟹   ENSMUSP00000110141
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl223,893,541 - 23,938,878 (-)Ensembl
GRCm38.p6 Ensembl224,003,529 - 24,048,866 (-)Ensembl
RefSeq Acc Id: ENSMUST00000114498   ⟹   ENSMUSP00000110142
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl223,892,952 - 23,939,091 (-)Ensembl
GRCm38.p6 Ensembl224,002,940 - 24,049,079 (-)Ensembl
RefSeq Acc Id: NM_080462   ⟹   NP_536710
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39223,892,923 - 23,939,391 (-)NCBI
GRCm38224,002,911 - 24,049,379 (-)NCBI
MGSCv37223,858,431 - 23,904,899 (-)RGD
Celera223,732,675 - 23,779,256 (-)RGD
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006497670   ⟹   XP_006497733
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39223,892,923 - 23,939,756 (-)NCBI
GRCm38224,002,911 - 24,049,758 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006497671   ⟹   XP_006497734
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39223,892,923 - 23,939,088 (-)NCBI
GRCm38224,003,302 - 24,049,066 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_536710   ⟸   NM_080462
- UniProtKB: Q3TVH0 (UniProtKB/Swiss-Prot),   Q91VF2 (UniProtKB/Swiss-Prot),   A2AQK4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006497733   ⟸   XM_006497670
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006497734   ⟸   XM_006497671
- Peptide Label: isoform X2
- UniProtKB: Q3TVH0 (UniProtKB/Swiss-Prot),   Q91VF2 (UniProtKB/Swiss-Prot),   A2AQK4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000062747   ⟸   ENSMUST00000051416
RefSeq Acc Id: ENSMUSP00000110142   ⟸   ENSMUST00000114498
RefSeq Acc Id: ENSMUSP00000110141   ⟸   ENSMUST00000114497

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q91VF2-F1-model_v2 AlphaFold Q91VF2 1-295 view protein structure

Promoters
RGD ID:6876502
Promoter ID:EPDNEW_M1701
Type:initiation region
Name:Hnmt_1
Description:Mus musculus histamine N-methyltransferase , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M1702  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38224,048,836 - 24,048,896EPDNEW
RGD ID:6876504
Promoter ID:EPDNEW_M1702
Type:initiation region
Name:Hnmt_2
Description:Mus musculus histamine N-methyltransferase , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M1701  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38224,049,395 - 24,049,455EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2153181 AgrOrtholog
Ensembl Genes ENSMUSG00000026986 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000051416 ENTREZGENE
  ENSMUST00000051416.12 UniProtKB/Swiss-Prot
  ENSMUST00000114497.2 UniProtKB/Swiss-Prot
  ENSMUST00000114498 ENTREZGENE
  ENSMUST00000114498.8 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.150 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro HHMT-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAM-dependent_MTases UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:140483 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:2153181 ENTREZGENE
NCBI Gene 140483 ENTREZGENE
Pfam Methyltransf_23 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB HNMT RGD
PhenoGen Hnmt PhenoGen
PIRSF HHMT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE SAM_HNMT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF53335 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A2AQK4 ENTREZGENE, UniProtKB/TrEMBL
  HNMT_MOUSE UniProtKB/Swiss-Prot
  Q3TVH0 ENTREZGENE
  Q91VF2 ENTREZGENE
UniProt Secondary Q3TVH0 UniProtKB/Swiss-Prot