Lpar3 (lysophosphatidic acid receptor 3) - Rat Genome Database

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Gene: Lpar3 (lysophosphatidic acid receptor 3) Mus musculus
Analyze
Symbol: Lpar3
Name: lysophosphatidic acid receptor 3
RGD ID: 734097
MGI Page MGI
Description: Predicted to enable G protein-coupled receptor activity; G-protein alpha-subunit binding activity; and phospholipid binding activity. Involved in gene expression. Acts upstream of or within several processes, including bleb assembly; positive regulation of MAPK cascade; and positive regulation of collateral sprouting. Located in axon. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system gland; and sensory organ. Orthologous to human LPAR3 (lysophosphatidic acid receptor 3).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Edg7; endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor 7; L; LPA receptor 3; LPA-3; lpA3; lysophosphatidic acid receptor Edg-7
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393145,926,716 - 145,991,969 (+)NCBIGRCm39mm39
GRCm39 Ensembl3145,926,718 - 145,991,941 (+)Ensembl
GRCm383146,220,961 - 146,286,214 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3146,220,963 - 146,286,186 (+)EnsemblGRCm38mm10GRCm38
MGSCv373145,883,925 - 145,949,178 (+)NCBIGRCm37mm9NCBIm37
MGSCv363146,158,371 - 146,223,572 (+)NCBImm8
Celera3152,671,994 - 152,737,437 (+)NCBICelera
Cytogenetic Map3H2NCBI
cM Map371.03NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11087877   PMID:11217851   PMID:11313151   PMID:12401212   PMID:12403827   PMID:12477932   PMID:12730698   PMID:15755723   PMID:15875025  
PMID:16141072   PMID:16141073   PMID:16462940   PMID:16602821   PMID:16782887   PMID:16815476   PMID:16829511   PMID:17135244   PMID:17709403   PMID:17823089   PMID:18287559   PMID:18448840  
PMID:18924241   PMID:20360252   PMID:20458606   PMID:20495828   PMID:20505096   PMID:20864640   PMID:21267068   PMID:21319224   PMID:21411082   PMID:21521824   PMID:21873635   PMID:22008794  
PMID:22222195   PMID:22465231   PMID:23451081   PMID:23843229   PMID:23909436   PMID:24429286   PMID:24602016   PMID:24829209   PMID:25406395   PMID:25411045   PMID:26447143   PMID:27760754  
PMID:27883026   PMID:28073697   PMID:28588064   PMID:29415171   PMID:29447019   PMID:30266753   PMID:30804442   PMID:31202927   PMID:31633020   PMID:33035680   PMID:33042260   PMID:33158924  
PMID:33317583   PMID:34292881   PMID:35151977  


Genomics

Comparative Map Data
Lpar3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393145,926,716 - 145,991,969 (+)NCBIGRCm39mm39
GRCm39 Ensembl3145,926,718 - 145,991,941 (+)Ensembl
GRCm383146,220,961 - 146,286,214 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3146,220,963 - 146,286,186 (+)EnsemblGRCm38mm10GRCm38
MGSCv373145,883,925 - 145,949,178 (+)NCBIGRCm37mm9NCBIm37
MGSCv363146,158,371 - 146,223,572 (+)NCBImm8
Celera3152,671,994 - 152,737,437 (+)NCBICelera
Cytogenetic Map3H2NCBI
cM Map371.03NCBI
LPAR3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38184,811,602 - 84,893,206 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl184,811,602 - 84,893,206 (-)EnsemblGRCh38hg38GRCh38
GRCh37185,277,285 - 85,358,889 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36185,052,090 - 85,104,430 (-)NCBINCBI36hg18NCBI36
Build 34184,991,521 - 85,043,863NCBI
Celera183,522,972 - 83,602,786 (-)NCBI
Cytogenetic Map1p22.3NCBI
HuRef183,389,042 - 83,468,839 (-)NCBIHuRef
CHM1_1185,393,947 - 85,473,763 (-)NCBICHM1_1
T2T-CHM13v2.0184,652,193 - 84,733,814 (-)NCBI
Lpar3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22235,125,234 - 235,193,916 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl2235,149,065 - 235,193,357 (+)Ensembl
Rnor_6.02252,090,634 - 252,159,221 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2252,090,669 - 252,159,903 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02270,610,856 - 270,679,592 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42244,431,789 - 244,510,815 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12244,418,528 - 244,497,555 (+)NCBI
Celera2227,128,872 - 227,173,700 (+)NCBICelera
Cytogenetic Map2q44NCBI
Lpar3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554239,063,804 - 9,133,230 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554239,063,804 - 9,133,203 (+)NCBIChiLan1.0ChiLan1.0
LPAR3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1186,219,789 - 86,274,228 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl186,222,008 - 86,274,228 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01117,359,661 - 117,441,297 (-)NCBIMhudiblu_PPA_v0panPan3
LPAR3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1663,035,332 - 63,114,697 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl663,035,746 - 63,113,251 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha665,683,188 - 65,761,599 (+)NCBI
ROS_Cfam_1.0663,572,971 - 63,651,406 (+)NCBI
ROS_Cfam_1.0 Ensembl663,596,424 - 63,651,257 (+)Ensembl
UMICH_Zoey_3.1663,102,662 - 63,181,018 (+)NCBI
UNSW_CanFamBas_1.0663,070,490 - 63,149,065 (+)NCBI
UU_Cfam_GSD_1.0663,578,995 - 63,657,390 (+)NCBI
Lpar3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505895,460,869 - 95,534,416 (-)NCBI
SpeTri2.0NW_004936608771,618 - 845,176 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LPAR3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6128,860,210 - 128,937,763 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16128,860,210 - 128,937,769 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26119,296,648 - 119,374,246 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap6q2.6-3.2NCBI
LPAR3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12048,457,903 - 48,538,754 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2048,485,708 - 48,540,513 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603369,229,208 - 69,311,934 (-)NCBIVero_WHO_p1.0
Lpar3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474212,616,910 - 12,691,496 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_00462474212,616,954 - 12,691,226 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
Edg7  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map3H2UniSTS
cM Map370.5UniSTS
cM Map370.5UniSTS
Edg7  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map3H2UniSTS
cM Map370.5UniSTS
Edg7  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map3H2UniSTS
cM Map370.5UniSTS


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1302056Orgwq4_morgan weight QTL 4 (mouse)Not determined330067588147304689Mouse
27226732Tibmd3_mtibia midshaft diameter 3, 10 week (mouse)396607316147805636Mouse
1300752Ap6q_malcohol preference 6 QTL (mouse)Not determined3100372912147045722Mouse
27226733Tibmd6_mtibia midshaft diameter 6, 16 week (mouse)3101307316149805637Mouse
1302093Orgwq5_morgan weight QTL 5 (mouse)Not determined3107376936147304689Mouse
1301100Bdt2_mbone density traits 2 (mouse)Not determined3114736617148736784Mouse
10043919Afpq8_mabdominal fat percent QTL 8 (mouse)Not determined3119057332153057456Mouse
1558868Ses9_msalmonella enteritidis susceptibility 9 (mouse)Not determined3119057332153057456Mouse
4141935Tgq15_mtriglyceride QTL 15 (mouse)Not determined119318586153318586Mouse
4142449Tgq14_mtriglyceride QTL 14 (mouse)Not determined119318586153318586Mouse
1302151Lprm2_mlymphoproliferation modifier 2 (mouse)Not determined3119778857153779044Mouse
10412240Alpq6_malcohol preference QTL 6 (mouse)Not determined3120772078154772078Mouse
4142245Pstc1_mperiosteal circumference 1 (mouse)Not determined3126270248159745316Mouse
1301218Letohc1_mlow ethanol consumption 1 (mouse)Not determined3126352986159745316Mouse
1301347Fpli_mfasting plasma insulin (mouse)Not determined3126460514159745316Mouse
1301563Alcp3_malcohol preference locus 3 (mouse)Not determined3130736935159745316Mouse
11039523Tbbr1_mTrypanosoma brucei brucei response 1 (mouse)3130849375159745316Mouse
1300753Eae10_msusceptibility to experimental allergic encephalomyelitis 10 (mouse)Not determined3131736617148451178Mouse
10412120Ccs3_mcolon cancer susceptibility 3 (mouse)Not determined3131754536146017669Mouse
1301528Loco1_mlocomotor activity 1 (mouse)Not determined3133461893159745316Mouse
1301221Hrtfm2_mheart failure modifier 2 (mouse)Not determined3143270248147045722Mouse
1301222Scc7_mcolon tumor susceptibility 7 (mouse)Not determined3143352986156364108Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:389
Count of miRNA genes:289
Interacting mature miRNAs:328
Transcripts:ENSMUST00000039164
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000039164   ⟹   ENSMUSP00000037712
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3145,926,718 - 145,991,941 (+)Ensembl
GRCm38.p6 Ensembl3146,220,963 - 146,286,186 (+)Ensembl
RefSeq Acc Id: NM_022983   ⟹   NP_075359
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393145,926,716 - 145,991,969 (+)NCBI
GRCm383146,220,961 - 146,286,214 (+)ENTREZGENE
MGSCv373145,883,925 - 145,949,178 (+)RGD
Celera3152,671,994 - 152,737,437 (+)RGD
cM Map3 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_075359   ⟸   NM_022983
- UniProtKB: Q9EQ31 (UniProtKB/Swiss-Prot),   Q544B4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000037712   ⟸   ENSMUST00000039164
Protein Domains
G_PROTEIN_RECEP_F1_2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9EQ31-F1-model_v2 AlphaFold Q9EQ31 1-354 view protein structure

Promoters
RGD ID:6834038
Promoter ID:MM_KWN:36356
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney
Transcripts:NM_022983
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv363145,883,721 - 145,884,221 (+)MPROMDB
RGD ID:6882594
Promoter ID:EPDNEW_M4748
Type:initiation region
Name:Lpar3_1
Description:Mus musculus lysophosphatidic acid receptor 3 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm383146,221,024 - 146,221,084EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1929469 AgrOrtholog
Ensembl Genes ENSMUSG00000036832 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000037712 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000039164 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LPA_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LPA_rcpt_EDG7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:65086 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1929469 ENTREZGENE
NCBI Gene 65086 ENTREZGENE
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Lpar3 PhenoGen
PRINTS EDG7RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LPARECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt LPAR3_MOUSE UniProtKB/Swiss-Prot
  Q544B4 ENTREZGENE, UniProtKB/TrEMBL
  Q9EQ31 ENTREZGENE