Lipc (lipase, hepatic) - Rat Genome Database

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Gene: Lipc (lipase, hepatic) Mus musculus
Analyze
Symbol: Lipc
Name: lipase, hepatic
RGD ID: 10871
MGI Page MGI
Description: Enables lipase activity. Acts upstream of or within cholesterol homeostasis; cholesterol metabolic process; and cholesterol transport. Located in extracellular space. Is expressed in liver and liver lobe. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; familial combined hyperlipidemia; glucose metabolism disease (multiple); obesity; and peripheral vascular disease. Orthologous to human LIPC (lipase C, hepatic type); PARTICIPATES IN D-glycericacidemia pathway; familial lipoprotein lipase deficiency pathway; glycerol kinase deficiency pathway; INTERACTS WITH 1-octadecanoyl-2-[(9Z)-octadecenoyl]-sn-glycerol; 1-palmitoyl-2-oleoyl-sn-glycerol; 1-stearoyl-2-linoleoyl-sn-glycerol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI256194; H; hepatic lipase; hepatic triacylglycerol lipase; HL; Hpl; lipase member C; lysophospholipase; phospholipase A1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39970,705,410 - 70,859,503 (-)NCBIGRCm39mm39
GRCm39 Ensembl970,705,410 - 70,859,508 (-)Ensembl
GRCm38970,798,128 - 70,952,221 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl970,798,128 - 70,952,226 (-)EnsemblGRCm38mm10GRCm38
MGSCv37970,645,935 - 70,782,615 (-)NCBIGRCm37mm9NCBIm37
MGSCv36970,597,345 - 70,734,025 (-)NCBImm8
Celera968,015,071 - 68,150,792 (-)NCBICelera
Cytogenetic Map9DNCBI
cM Map939.57NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
1-naphthyl isothiocyanate  (ISO)
1-octadecanoyl-2-[(9Z)-octadecenoyl]-sn-glycerol  (EXP)
1-palmitoyl-2-oleoyl-sn-glycerol  (EXP)
1-stearoyl-2-linoleoyl-sn-glycerol  (EXP)
1-stearoyl-sn-glycero-3-phosphocholine  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (ISO)
6-propyl-2-thiouracil  (ISO)
8-Br-cAMP  (ISO)
acetamide  (ISO)
acrolein  (EXP)
aflatoxin B1  (EXP,ISO)
amiodarone  (ISO)
ammonium chloride  (ISO)
arachidonic acid  (EXP)
aristolochic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atenolol  (ISO)
bazedoxifene  (ISO)
benzbromarone  (ISO)
benzo[a]pyrene  (ISO)
bezafibrate  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buspirone  (ISO)
butanal  (ISO)
C60 fullerene  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (EXP)
chloroform  (ISO)
cholesteryl arachidonate  (EXP)
cholesteryl linoleate  (EXP)
cholesteryl linolenate  (EXP)
cholesteryl myristate  (EXP)
cholesteryl oleate  (EXP)
cholesteryl palmitate  (EXP)
ciglitazone  (ISO)
clofibrate  (ISO)
copper(II) sulfate  (ISO)
curcumin  (EXP)
cyclosporin A  (ISO)
dexamethasone  (ISO)
dichlorine  (ISO)
diclofenac  (EXP)
diosgenin  (ISO)
erythromycin estolate  (ISO)
ethanol  (EXP)
farnesol  (ISO)
fipronil  (ISO)
flutamide  (ISO)
fluvastatin  (ISO)
folic acid  (EXP)
furan  (ISO)
genistein  (ISO)
glafenine  (ISO)
GW 4064  (ISO)
GW 501516  (ISO)
hexadecanoic acid  (EXP)
high-density lipoprotein cholesterol  (ISO)
hydrazine  (ISO)
indometacin  (ISO)
isotretinoin  (ISO)
L-ethionine  (ISO)
linoleic acid  (EXP)
lipopolysaccharide  (EXP)
lovastatin  (EXP)
methapyrilene  (ISO)
methotrexate  (ISO)
N-hexadecanoylsphingosine  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-Nitrosopyrrolidine  (ISO)
naloxone  (ISO)
nefazodone  (ISO)
nimesulide  (ISO)
O-methyleugenol  (ISO)
obeticholic acid  (ISO)
oleic acid  (EXP,ISO)
omeprazole  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorohexanesulfonic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (ISO)
phosphatidylcholine  (EXP)
pioglitazone  (EXP)
pirinixic acid  (EXP,ISO)
propiconazole  (EXP)
quercetin  (ISO)
quinidine  (ISO)
rebaudioside A  (EXP)
rimonabant  (EXP)
rotenone  (ISO)
silicon dioxide  (ISO)
sodium dichromate  (ISO)
sorafenib  (ISO)
steviol  (EXP)
stevioside  (EXP)
streptozocin  (EXP)
tamoxifen  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
theophylline  (ISO)
thioacetamide  (ISO)
trimellitic anhydride  (EXP)
triphenyl phosphate  (ISO)
valdecoxib  (ISO)
valproic acid  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to hormone stimulus  (ISO)
cholesterol homeostasis  (IGI,ISO)
cholesterol metabolic process  (IGI)
cholesterol transport  (IMP)
chylomicron remnant clearance  (ISO)
chylomicron remodeling  (ISO)
circadian rhythm  (ISO)
developmental growth  (ISO)
fatty acid biosynthetic process  (IBA,ISO)
fatty acid metabolic process  (ISO)
glycerophospholipid catabolic process  (ISO)
heparan sulfate proteoglycan biosynthetic process  (ISO)
high-density lipoprotein particle remodeling  (ISO)
lipid catabolic process  (IBA)
lipid metabolic process  (IEA)
liver development  (ISO)
low-density lipoprotein particle clearance  (ISO)
low-density lipoprotein particle remodeling  (ISO)
neutral lipid catabolic process  (ISO)
phosphatidic acid metabolic process  (ISO)
phosphatidylcholine metabolic process  (ISO)
phosphatidylethanolamine metabolic process  (ISO)
phosphatidylserine metabolic process  (ISO)
regulation of plasma lipoprotein particle levels  (ISO)
response to acetate  (ISO)
response to amino acid  (ISO)
response to calcium ion  (ISO)
response to carbohydrate  (ISO)
response to copper ion  (ISO)
response to fatty acid  (ISO)
response to glucocorticoid  (ISO)
response to hormone  (ISO)
response to hypoxia  (ISO)
response to inorganic substance  (ISO)
response to lipid  (ISO)
response to magnesium ion  (ISO)
response to nutrient levels  (ISO)
response to organic cyclic compound  (ISO)
response to peptide hormone  (ISO)
response to xenobiotic stimulus  (ISO)
triglyceride catabolic process  (IBA,ISO)
triglyceride homeostasis  (ISO)
triglyceride metabolic process  (ISO)
very-low-density lipoprotein particle remodeling  (ISO)

Cellular Component

References

References - curated
1. Agardh CD, etal., Acta Med Scand. 1983;213(2):123-8.
2. Al Majali K, etal., Diabetologia. 2006 Mar;49(3):527-37. Epub 2006 Jan 21.
3. Baum L, etal., Diabetes Care. 2005 Jul;28(7):1704-9.
4. Baynes C, etal., Eur J Clin Invest. 1992 May;22(5):341-6.
5. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
6. Black DD, etal., Metabolism. 1982 Jun;31(6):620-6.
7. Caixas A, etal., Metabolism. 1998 Apr;47(4):371-6.
8. Cenarro A, etal., Am Heart J. 2005 Dec;150(6):1154-62.
9. Costacou T, etal., Am J Epidemiol. 2006 Nov 1;164(9):862-72. Epub 2006 Aug 23.
10. de Andrade FM, etal., Clin Genet. 2004 May;65(5):390-5.
11. Franco M, etal., Mol Cell Biochem. 2003 Apr;246(1-2):51-6.
12. Garber DW, etal., J Clin Invest. 1984 Oct;74(4):1375-83.
13. Groop PH, etal., Diabetes. 1996 Jul;45(7):974-9.
14. Hokanson JE, etal., Diabetes. 2002 Apr;51(4):1208-13.
15. Klin M, etal., J Clin Invest. 1996 May 15;97(10):2167-73.
16. Knauer TE, etal., J Lipid Res. 1982 May;23(4):631-7.
17. Komaromy MC and Schotz MC, Proc Natl Acad Sci U S A 1987 Mar;84(6):1526-30.
18. Kong C, etal., Atherosclerosis. 2001 Jun;156(2):373-8.
19. Lamri MY, etal., J Nutr. 1995 Sep;125(9):2425-34.
20. Levy E and Bendayan M, Diabete Metab. 1991 Jan-Feb;17(1):44-8.
21. Liang K and Vaziri ND, Kidney Int. 1997 Jun;51(6):1933-7.
22. Meraihi Z, etal., Infusionstherapie. 1990 Apr;17(2):104-7.
23. Merzouk H, etal., Clin Sci (Lond). 2000 Jan;98(1):21-30.
24. MGD and Homologene mouse data transfer
25. MGD data from the GO Consortium
26. MGD IEA
27. Neve BP, etal., Biochim Biophys Acta. 1997 Apr 1;1345(2):172-9.
28. Nikkila EA, etal., Diabetes. 1977 Jan;26(1):11-21.
29. Ohashi R, etal., QJM. 2005 Dec;98(12):845-56. Epub 2005 Oct 28.
30. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
31. OMIM Disease Annotation Pipeline
32. Park KW, etal., J Biochem Mol Biol. 2003 Mar 31;36(2):237-42.
33. Peinado-Onsurbe J, etal., Horm Metab Res. 2001 Aug;33(8):458-62.
34. Pipeline to import SMPDB annotations from SMPDB into RGD
35. RGD automated import pipeline
36. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
37. RGD automated import pipeline for gene-chemical interactions
38. Rivellese AA, etal., J Clin Endocrinol Metab. 2000 Nov;85(11):4188-92.
39. Sato T, etal., Kidney Int. 2003 Nov;64(5):1780-6.
40. Shearer GC, etal., Kidney Int. 2000 Jun;57(6):2268-74.
41. Shih DQ, etal., Nat Genet. 2001 Apr;27(4):375-82.
42. Sibley SD, etal., J Clin Endocrinol Metab. 2003 Jul;88(7):3379-84.
43. Sjovall S, etal., J Hepatol. 1991 Jul;13(1):33-7.
44. Sultan F, etal., Life Sci. 1995;56(1):31-7.
45. Tan KC, etal., Atherosclerosis. 2001 Jul;157(1):233-9.
46. Valdivielso P, etal., J Diabetes Complications. 2008 Jul-Aug;22(4):273-7. Epub 2008 Apr 16.
47. van Deursen D, etal., Diabetologia. 2008 Nov;51(11):2078-87. Epub 2008 Aug 30.
48. Warden CH, etal., Genomics 1993 Nov;18(2):295-307.
49. Wasan KM, etal., J Pharm Pharm Sci. 2003 May-Aug;6(2):189-97.
50. Zacharova J, etal., J Intern Med. 2005 Feb;257(2):185-93.
51. Zambon A, etal., Curr Opin Lipidol. 2003 Apr;14(2):179-89.
52. Zhang C, etal., Am J Clin Nutr. 2005 Jun;81(6):1429-35.
53. Zhang C, etal., Diabetologia. 2006 Jul;49(7):1552-9. Epub 2006 Mar 29.
54. Zhu H, etal., Neurobiol Aging. 2006 Dec 15;.
Additional References at PubMed
PMID:1840530   PMID:2025643   PMID:2563260   PMID:3109891   PMID:6804942   PMID:6812053   PMID:7852377   PMID:8105016   PMID:8560269   PMID:8672141   PMID:8798380   PMID:8827514  
PMID:9153204   PMID:9338114   PMID:9442022   PMID:9606417   PMID:9616220   PMID:9630674   PMID:9717727   PMID:9861024   PMID:9918035   PMID:10349636   PMID:10357838   PMID:10482304  
PMID:10744773   PMID:10787427   PMID:11042159   PMID:11076861   PMID:11208732   PMID:11217851   PMID:11290828   PMID:11842132   PMID:11906928   PMID:11971936   PMID:12117557   PMID:12477932  
PMID:12700335   PMID:12897204   PMID:12939599   PMID:12975454   PMID:14610273   PMID:14679168   PMID:14681479   PMID:14974682   PMID:14981222   PMID:15181537   PMID:15205216   PMID:15304509  
PMID:15314098   PMID:15520453   PMID:15995171   PMID:16141072   PMID:16141073   PMID:16368783   PMID:16397139   PMID:16498401   PMID:17071916   PMID:17103052   PMID:17234195   PMID:17431181  
PMID:17872590   PMID:18175806   PMID:18599739   PMID:19136429   PMID:19524061   PMID:19965617   PMID:20056822   PMID:20373033   PMID:20558822   PMID:21267068   PMID:21677750   PMID:21730028  
PMID:21750705   PMID:21873635   PMID:22323595   PMID:23328279   PMID:23355893   PMID:23376223   PMID:24440515   PMID:24777581   PMID:24818611   PMID:25209997   PMID:25862097   PMID:25875831  
PMID:26423094   PMID:27172975   PMID:31202927   PMID:32325033  


Genomics

Comparative Map Data
Lipc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39970,705,410 - 70,859,503 (-)NCBIGRCm39mm39
GRCm39 Ensembl970,705,410 - 70,859,508 (-)Ensembl
GRCm38970,798,128 - 70,952,221 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl970,798,128 - 70,952,226 (-)EnsemblGRCm38mm10GRCm38
MGSCv37970,645,935 - 70,782,615 (-)NCBIGRCm37mm9NCBIm37
MGSCv36970,597,345 - 70,734,025 (-)NCBImm8
Celera968,015,071 - 68,150,792 (-)NCBICelera
Cytogenetic Map9DNCBI
cM Map939.57NCBI
LIPC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1558,410,569 - 58,569,844 (+)EnsemblGRCh38hg38GRCh38
GRCh381558,410,457 - 58,569,844 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371558,724,190 - 58,862,043 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361556,511,467 - 56,648,364 (+)NCBINCBI36hg18NCBI36
Build 341556,511,466 - 56,648,364NCBI
Celera1535,612,421 - 35,749,365 (+)NCBI
Cytogenetic Map15q21.3NCBI
HuRef1535,547,160 - 35,684,065 (+)NCBIHuRef
CHM1_11558,842,117 - 58,978,999 (+)NCBICHM1_1
Lipc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2871,509,633 - 71,635,663 (-)NCBImRatBN7.2
Rnor_6.0 Ensembl877,272,570 - 77,398,248 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0877,272,582 - 77,398,485 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0875,686,187 - 75,812,459 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4875,323,442 - 75,450,353 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1875,342,496 - 75,469,407 (-)NCBI
Celera870,101,863 - 70,227,531 (+)NCBICelera
Cytogenetic Map8q24NCBI
Lipc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545015,948,187 - 16,048,766 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545015,947,869 - 16,062,449 (-)NCBIChiLan1.0ChiLan1.0
LIPC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11555,688,414 - 55,847,005 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1555,814,017 - 55,847,005 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01537,363,507 - 37,537,723 (+)NCBIMhudiblu_PPA_v0panPan3
LIPC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13023,432,460 - 23,584,037 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3023,432,493 - 23,584,037 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3023,404,560 - 23,555,900 (+)NCBI
ROS_Cfam_1.03023,597,357 - 23,749,167 (+)NCBI
UMICH_Zoey_3.13023,523,240 - 23,674,537 (+)NCBI
UNSW_CanFamBas_1.03023,608,314 - 23,759,924 (+)NCBI
UU_Cfam_GSD_1.03023,750,266 - 23,901,905 (+)NCBI
Lipc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640101,755,855 - 101,885,658 (+)NCBI
SpeTri2.0NW_00493647119,604,083 - 19,733,721 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LIPC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1113,433,679 - 113,604,306 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11113,433,684 - 113,604,139 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21125,418,537 - 125,667,649 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LIPC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12624,946,843 - 25,109,338 (-)NCBI
ChlSab1.1 Ensembl2624,946,673 - 25,087,921 (-)Ensembl
Vero_WHO_p1.0NW_023666048116,211,906 - 116,373,902 (+)NCBI
Lipc
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462478113,342,469 - 13,468,120 (-)NCBI

Position Markers
RH136292  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38970,853,733 - 70,853,931UniSTSGRCm38
GRCm381583,116,380 - 83,116,578UniSTSGRCm38
MGSCv371582,946,810 - 82,947,008UniSTSGRCm37
MGSCv37970,701,540 - 70,701,738UniSTSGRCm37
Celera968,070,690 - 68,070,888UniSTS
Celera1585,249,722 - 85,249,920UniSTS
Cytogenetic Map9DUniSTS
Cytogenetic Map15E1UniSTS
cM Map939.0UniSTS
fb95b03.x1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv37970,742,450 - 70,742,634UniSTSGRCm37
MGSCv37970,742,450 - 70,742,620UniSTSGRCm37
Celera968,111,617 - 68,111,783UniSTS
Celera968,111,617 - 68,111,781UniSTS
Celera968,111,617 - 68,111,771UniSTS
Celera968,111,617 - 68,111,801UniSTS
Cytogenetic Map9DUniSTS
cM Map939.0UniSTS
AI256194  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38970,802,125 - 70,802,218UniSTSGRCm38
MGSCv37970,649,932 - 70,650,025UniSTSGRCm37
Celera968,019,066 - 68,019,159UniSTS
Cytogenetic Map9DUniSTS
cM Map939.0UniSTS
Whitehead/MRC_RH9686.22UniSTS
RH94786  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38970,798,222 - 70,798,299UniSTSGRCm38
MGSCv37970,646,029 - 70,646,106UniSTSGRCm37
Celera968,015,165 - 68,015,242UniSTS
Cytogenetic Map9DUniSTS
cM Map939.0UniSTS
RH125770  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381583,116,374 - 83,116,594UniSTSGRCm38
GRCm38970,853,717 - 70,853,937UniSTSGRCm38
MGSCv371582,946,804 - 82,947,024UniSTSGRCm37
MGSCv37970,701,524 - 70,701,744UniSTSGRCm37
Celera968,070,674 - 68,070,894UniSTS
Celera1585,249,716 - 85,249,936UniSTS
Cytogenetic Map9DUniSTS
Cytogenetic Map15E1UniSTS
cM Map939.0UniSTS
UniSTS:237704  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38970,852,674 - 70,852,844UniSTSGRCm38
MGSCv37970,700,481 - 70,700,651UniSTSGRCm37
Celera968,069,631 - 68,069,801UniSTS
Cytogenetic Map15E1UniSTS
Cytogenetic Map9DUniSTS
cM Map939.0UniSTS
Lipc  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9DUniSTS
cM Map939.57UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558872Ibdq1_minflammatory bowel disease QTL 1 (mouse)Not determined93406754473531973Mouse
4142042Alpq3_malcohol preference QTL 3 (mouse)Not determined93739490198819654Mouse
10043971Obq32_mobesity QTL 32 (mouse)Not determined93791224471912244Mouse
12791002Arlsq2_maortic root lesion size QTL 2 (mouse)93819229172192291Mouse
12790986Pcho9_mplasma cholesterol 9 (mouse)93819229172192291Mouse
12790992Arlsq1_maortic root lesion size QTL 1 (mouse)93819229172192291Mouse
12738449Spcq2_msperm count QTL 2 (mouse)93949260173492601Mouse
4141071Ath29_matherosclerosis 29 (mouse)Not determined94050829874700643Mouse
1301702Brm1_mbrachyury modifier 1 (mouse)Not determined94089776474897921Mouse
1301558Stheal8_msoft tissue heal 8 (mouse)Not determined94357343177573577Mouse
10045639Heal28_mwound healing/regeneration 28 (mouse)Not determined94357343177573577Mouse
1301435Trigq1_mtriglyceride QTL 1 (mouse)Not determined94452089278520980Mouse
1300716Cd4ts4_mCD4 T cell subset 4 (mouse)Not determined94892377482923895Mouse
1300563Pgia5_mproteoglycan induced arthritis 5 (mouse)Not determined94892377482923895Mouse
4141224Dxmod_mdoxorubicin nephropathy modifier (mouse)Not determined49541121101528921Mouse
14746993Manh66_mmandible shape 66 (mouse)94990676683906766Mouse
1301184Bdln4_mbody length 4 (mouse)Not determined95024403884244166Mouse
1301241Renf1_mrenal failure 1 (mouse)Not determined95212317899910428Mouse
12790990Tgl7_mtriglyceride 7 (mouse)95465267888652678Mouse
10043877Adip21_madiposity 21 (mouse)Not determined95653182690531973Mouse
1301549Bbaa9_mB.burgdorferi-associated arthritis 9 (mouse)Not determined95789776471574472Mouse
4141676Neogq1_mneonatal growth QTL 1 (mouse)Not determined95789776486239920Mouse
1301172Fembrs6_mfemur breaking strength 6 (mouse)Not determined95911710593117252Mouse
1301803Stheal9_msoft tissue heal 9 (mouse)Not determined95911710593117252Mouse
5491195Mobq8_mmultigenic obesity QTL 8 (mouse)Not determined95946266493462846Mouse
1300848Skull13_mskull morphology 13 (mouse)Not determined95946266493462846Mouse
1301456Adip5_madiposity 5 (mouse)Not determined95946266493462846Mouse
13207569Tcq13_mtotal cholesterol QTL 13 (mouse)959990000109260000Mouse
1301611Lrnx3_mlearning contextual 3 (mouse)Not determined96224248596242599Mouse
4141833W10q13_mweight 10 weeks QTL 13 (mouse)Not determined63332429120362868Mouse
4141545Tailaq2_mtail length adjusted QTL 2 (mouse)Not determined63332429120362868Mouse
1357635Splq4_mspleen weight QTL 4 (mouse)Not determined963332429120362868Mouse
11081165Psl6_mpromotion susceptibility QTL 6 (mouse)96513390995640755Mouse
1301290Smgd1_msubmucosal gland distribution 1 (mouse)Not determined96592377486695914Mouse
1301636Lith5_mlithogenic gene 5 (mouse)Not determined966207024100207122Mouse
10045638Heal29_mwound healing/regeneration 29 (mouse)Not determined967124167101124167Mouse
1357610Vtbt8_mvertebral trabecular bone trait 8 (mouse)Not determined968897510102897652Mouse
1301924Bmd10_mbone mineral density 10 (mouse)Not determined968897510102897652Mouse
1301302Pas4_mpulmonary adenoma susceptibility 4 (mouse)Not determined969239845103239920Mouse
10412174Habiir4_mhyperoxic acute lung injury imprinted region 4 (mouse)Not determined96936046598819654Mouse
1301621Hpic1_mhaloperidol-induced catalepsy 1 (mouse)Not determined969546513103546645Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:56
Count of miRNA genes:55
Interacting mature miRNAs:56
Transcripts:ENSMUST00000034731
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001324472 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001324473 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_008280 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006510816 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006510817 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006510818 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030244061 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030244062 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036154612 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC137843 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK158285 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK158360 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY228765 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC021841 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC094050 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY337256 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466522 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CT025701 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M28328 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X58426 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000034731   ⟹   ENSMUSP00000034731
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl970,798,128 - 70,934,808 (-)Ensembl
RefSeq Acc Id: ENSMUST00000214995   ⟹   ENSMUSP00000149638
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl970,820,852 - 70,934,613 (-)Ensembl
RefSeq Acc Id: ENSMUST00000215814
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl970,823,524 - 70,952,221 (-)Ensembl
RefSeq Acc Id: ENSMUST00000216798   ⟹   ENSMUSP00000149185
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl970,798,172 - 70,952,226 (-)Ensembl
RefSeq Acc Id: NM_001324472   ⟹   NP_001311401
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39970,705,410 - 70,859,503 (-)NCBI
GRCm38970,798,128 - 70,952,221 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001324473   ⟹   NP_001311402
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39970,705,410 - 70,859,503 (-)NCBI
GRCm38970,798,128 - 70,952,221 (-)NCBI
Sequence:
RefSeq Acc Id: NM_008280   ⟹   NP_032306
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39970,705,410 - 70,842,090 (-)NCBI
GRCm38970,798,128 - 70,934,808 (-)NCBI
MGSCv37970,645,935 - 70,782,615 (-)RGD
Celera968,015,071 - 68,150,792 (-)RGD
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006510816   ⟹   XP_006510879
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39970,705,448 - 70,842,125 (-)NCBI
GRCm38970,798,166 - 70,934,844 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006510817   ⟹   XP_006510880
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39970,705,448 - 70,742,339 (-)NCBI
GRCm38970,798,166 - 70,835,178 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006510818   ⟹   XP_006510881
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39970,719,402 - 70,842,126 (-)NCBI
GRCm38970,812,120 - 70,934,844 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030244061   ⟹   XP_030099921
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39970,705,448 - 70,842,125 (-)NCBI
GRCm38970,798,166 - 70,934,843 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030244062   ⟹   XP_030099922
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39970,719,402 - 70,842,125 (-)NCBI
GRCm38970,812,120 - 70,934,843 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036154612   ⟹   XP_036010505
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39970,705,448 - 70,746,346 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_032306   ⟸   NM_008280
- Peptide Label: isoform 1 precursor
- UniProtKB: P27656 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006510879   ⟸   XM_006510816
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006510880   ⟸   XM_006510817
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_006510881   ⟸   XM_006510818
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: NP_001311402   ⟸   NM_001324473
- Peptide Label: isoform 2
- UniProtKB: P27656 (UniProtKB/Swiss-Prot),   Q3TYU0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001311401   ⟸   NM_001324472
- Peptide Label: isoform 1 precursor
- UniProtKB: P27656 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_030099921   ⟸   XM_030244061
- Peptide Label: isoform X2
RefSeq Acc Id: XP_030099922   ⟸   XM_030244062
- Peptide Label: isoform X5
RefSeq Acc Id: ENSMUSP00000149185   ⟸   ENSMUST00000216798
RefSeq Acc Id: ENSMUSP00000034731   ⟸   ENSMUST00000034731
RefSeq Acc Id: ENSMUSP00000149638   ⟸   ENSMUST00000214995
RefSeq Acc Id: XP_036010505   ⟸   XM_036154612
- Peptide Label: isoform X3
Protein Domains
Lipase   PLAT

Promoters
RGD ID:6844748
Promoter ID:MM_KWN:57989
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:NM_008280
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36970,782,306 - 70,782,806 (-)MPROMDB
RGD ID:8670108
Promoter ID:EPDNEW_M13085
Type:multiple initiation site
Name:Lipc_1
Description:Mus musculus lipase, hepatic , transcript variant 3, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M13086  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38970,934,610 - 70,934,670EPDNEW
RGD ID:8670114
Promoter ID:EPDNEW_M13086
Type:multiple initiation site
Name:Lipc_2
Description:Mus musculus lipase, hepatic , transcript variant 3, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M13085  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38970,934,835 - 70,934,895EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:96216 AgrOrtholog
Ensembl Genes ENSMUSG00000032207 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000034731 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000149185 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSP00000149638 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000034731 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000214995 UniProtKB/TrEMBL
  ENSMUST00000216798 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.1820 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AB_hydrolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lipase/vitellogenin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lipase_hep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lipase_LIPH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lipase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLAT/LH2_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLAT/LH2_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TAG_lipase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:15450 UniProtKB/Swiss-Prot
MGD MGI:96216 ENTREZGENE
NCBI Gene 15450 ENTREZGENE
PANTHER PTHR11610 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11610:SF2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Lipase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB LIPC RGD
PhenoGen Lipc PhenoGen
PIRSF Lipoprotein_lipase_LIPH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS HEPLIPASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TAGLIPASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE LIPASE_SER UniProtKB/Swiss-Prot
  PLAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART LH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49723 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF53474 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A1L1SRU8_MOUSE UniProtKB/TrEMBL
  LIPC_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3TYU0 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q8VC44 UniProtKB/Swiss-Prot