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Gene: Jph2 (junctophilin 2) Mus musculus
Symbol: Jph2
Name: junctophilin 2
Description: Exhibits DNA-binding transcription repressor activity, RNA polymerase II-specific and core promoter binding activity. Involved in negative regulation of transcription by RNA polymerase II; positive regulation of cytosolic calcium ion concentration; and regulation of cardiac muscle tissue development. Localizes to several cellular components, including the Z disc; junctional membrane complex; and sarcoplasmic reticulum. Human ortholog(s) of this gene implicated in hypertrophic cardiomyopathy 17. Is expressed in heart; lung; skeletal muscle; and stomach. Orthologous to human JPH2 (junctophilin 2); INTERACTS WITH 4,4'-diaminodiphenylmethane; 4,4'-sulfonyldiphenol; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 1110002E14Rik; JP-2; Jp2; junctophilin type 2; junctophilin-2
Homo sapiens (human) : JPH2 (junctophilin 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Jph2 (junctophilin 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Jph2 (junctophilin 2)
Pan paniscus (bonobo/pygmy chimpanzee) : JPH2 (junctophilin 2)
Canis lupus familiaris (dog) : JPH2 (junctophilin 2)
Sus scrofa (pig) : JPH2 (junctophilin 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm382163,336,242 - 163,398,049 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv372163,163,509 - 163,223,686 (-)NCBIGRCm37mm9NCBIm37
MGSCv362163,029,214 - 163,089,391 (-)NCBImm8
Celera2169,285,971 - 169,347,706 (-)NCBICelera
Cytogenetic Map2 H2-H3NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Jph2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1313082
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2019-10-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.