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Gene: Jph2 (junctophilin 2) Mus musculus
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Symbol: Jph2
Name: junctophilin 2
Description: Exhibits DNA-binding transcription repressor activity, RNA polymerase II-specific and core promoter binding activity. Involved in negative regulation of transcription by RNA polymerase II; positive regulation of cytosolic calcium ion concentration; and regulation of cardiac muscle tissue development. Localizes to several cellular components, including the Z disc; junctional membrane complex; and sarcoplasmic reticulum. Human ortholog(s) of this gene implicated in hypertrophic cardiomyopathy 17. Is expressed in heart; lung; skeletal muscle; and stomach. Orthologous to human JPH2 (junctophilin 2); INTERACTS WITH 4,4'-diaminodiphenylmethane; 4,4'-sulfonyldiphenol; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 1110002E14Rik; JP-2; Jp2; junctophilin type 2; junctophilin-2
Orthologs:
Homo sapiens (human) : JPH2 (junctophilin 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Jph2 (junctophilin 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Jph2 (junctophilin 2)
Pan paniscus (bonobo/pygmy chimpanzee) : JPH2 (junctophilin 2)
Canis lupus familiaris (dog) : JPH2 (junctophilin 2)
Sus scrofa (pig) : JPH2 (junctophilin 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm382163,336,242 - 163,398,049 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv372163,163,509 - 163,223,686 (-)NCBIGRCm37mm9NCBIm37
MGSCv362163,029,214 - 163,089,391 (-)NCBImm8
Celera2169,285,971 - 169,347,706 (-)NCBICelera
Cytogenetic Map2 H2-H3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Jph2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1313082
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.