Plpp6 (phospholipid phosphatase 6) - Rat Genome Database

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Gene: Plpp6 (phospholipid phosphatase 6) Mus musculus
Analyze
Symbol: Plpp6
Name: phospholipid phosphatase 6
RGD ID: 1621485
MGI Page MGI
Description: Predicted to enable isoprenoid diphosphate phosphatase activity and phosphatase activity. Predicted to be involved in phospholipid dephosphorylation; phospholipid metabolic process; and positive regulation of neutrophil activation. Predicted to act upstream of or within innate immune response and lipid metabolic process. Predicted to be located in endoplasmic reticulum membrane and nuclear membrane. Predicted to be active in membrane. Is expressed in several structures, including eye; genitourinary system; gut; nervous system; and skin. Orthologous to human PLPP6 (phospholipid phosphatase 6).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 4932443D16Rik; phosphatidic acid phosphatase type 2 domain containing 2; phosphatidic acid phosphatase type 2 domain-containing protein 2; polyisoprenoid diphosphate/phosphate phosphohydrolase PLPP6; Ppa; Ppapdc2; presqualene diphosphate phosphatase
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391928,941,320 - 28,944,201 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1928,941,353 - 28,944,211 (+)EnsemblGRCm39 Ensembl
GRCm381928,963,920 - 28,966,801 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1928,963,953 - 28,966,811 (+)EnsemblGRCm38mm10GRCm38
MGSCv371929,038,410 - 29,041,291 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361929,029,917 - 29,032,791 (+)NCBIMGSCv36mm8
Celera1929,739,158 - 29,742,039 (+)NCBICelera
Cytogenetic Map19C1NCBI
cM Map1923.61NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Mouse MP Annotation Import Pipeline RGD automated import pipeline
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:15489334   PMID:15782199   PMID:16141072   PMID:16141073   PMID:17114649  
PMID:21267068   PMID:21873635   PMID:24194600   PMID:26839965   PMID:27626380   PMID:31138677   PMID:36238896   PMID:38355793  


Genomics

Comparative Map Data
Plpp6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391928,941,320 - 28,944,201 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1928,941,353 - 28,944,211 (+)EnsemblGRCm39 Ensembl
GRCm381928,963,920 - 28,966,801 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1928,963,953 - 28,966,811 (+)EnsemblGRCm38mm10GRCm38
MGSCv371929,038,410 - 29,041,291 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361929,029,917 - 29,032,791 (+)NCBIMGSCv36mm8
Celera1929,739,158 - 29,742,039 (+)NCBICelera
Cytogenetic Map19C1NCBI
cM Map1923.61NCBI
PLPP6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3894,662,294 - 4,665,258 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl94,662,294 - 4,665,258 (+)EnsemblGRCh38hg38GRCh38
GRCh3794,662,294 - 4,665,258 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3694,652,298 - 4,655,262 (+)NCBINCBI36Build 36hg18NCBI36
Celera94,584,804 - 4,587,764 (+)NCBICelera
Cytogenetic Map9p24.1NCBI
HuRef94,617,624 - 4,620,604 (+)NCBIHuRef
CHM1_194,662,354 - 4,665,334 (+)NCBICHM1_1
T2T-CHM13v2.094,665,968 - 4,668,932 (+)NCBIT2T-CHM13v2.0
Plpp6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81236,092,642 - 236,095,494 (+)NCBIGRCr8
mRatBN7.21226,679,100 - 226,681,952 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1226,679,100 - 226,681,949 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1235,082,556 - 235,085,408 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01242,012,220 - 242,015,072 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01234,837,588 - 234,840,440 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01247,084,228 - 247,087,080 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1247,084,228 - 247,087,077 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01254,323,970 - 254,326,822 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41232,598,621 - 232,601,473 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1223,831,932 - 223,834,784 (+)NCBICelera
Cytogenetic Map1q52NCBI
Plpp6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554348,953,152 - 8,954,033 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554348,953,069 - 8,955,866 (+)NCBIChiLan1.0ChiLan1.0
PLPP6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v211119,894,184 - 119,897,191 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan19119,900,131 - 119,903,215 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v094,494,408 - 4,497,405 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.194,682,531 - 4,685,484 (+)NCBIpanpan1.1PanPan1.1panPan2
PLPP6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1193,037,252 - 93,040,150 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl193,037,252 - 93,038,181 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha193,509,864 - 93,512,765 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0193,591,480 - 93,594,398 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1193,223,377 - 93,226,282 (+)NCBIUMICH_Zoey_3.1
UU_Cfam_GSD_1.0193,711,645 - 93,714,539 (+)NCBIUU_Cfam_GSD_1.0
Plpp6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947140,613,701 - 140,616,809 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936503558,219 - 559,103 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936503556,185 - 559,420 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLPP6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11274,878,131 - 74,881,106 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1274,880,128 - 74,881,015 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603863,207,038 - 63,210,004 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Plpp6
73 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:616
Count of miRNA genes:398
Interacting mature miRNAs:465
Transcripts:ENSMUST00000045674
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301271Datd_mdopamine transporter density (mouse)Not determined19132340234Mouse
13506250Renmq1_mrenal mercury accumulation QTL 1 (mouse)192738559461385705Mouse
10412251Mnp_mmodifier of Niemann Pick type C1 (mouse)Not determined192023431454234461Mouse
1357596Tgct3_mtesticular germ cell tumor 3 (mouse)Not determined192198409132912719Mouse
11039522Tbbr4_mTrypanosoma brucei brucei response 4 (mouse)19531332639313470Mouse
1301336Alcp23_malcohol preference locus 23 (mouse)Not determined191591260749912719Mouse
1558876W3q14_mweight 3 weeks QTL 14 (mouse)Not determined192231332653911504Mouse
1302019Pgia23_mproteoglycan induced arthritis 23 (mouse)Not determined19978745343787602Mouse
1301633Alcp24_malcohol preference locus 24 (mouse)Not determined191591260749912719Mouse
14928311Manh85_mmandible shape 85 (mouse)191191478945914789Mouse
1357568Tgct4_mtesticular germ cell tumor 4 (mouse)Not determined192777198535295381Mouse
1301451Ath16_matherosclerosis 16 (mouse)Not determined192542691759427005Mouse
4141659Pbwg20_mpostnatal body weight growth 20 (mouse)Not determined192137870555378928Mouse
10413881Moe2_mmodifier of epilepsy 2 (mouse)191492301648923138Mouse
1302004Lfp2_mlong free running period 2 (mouse)Not determined191829516252295381Mouse
1300923Bits4_mbitterness sensitivity 4 (mouse)Not determined19332321637323348Mouse
12790634Ebm1_mEpidermolysis Bullosa modifier 1 (mouse)192498843958988439Mouse
4141138Femwf11_mfemur work to failure 11 (mouse)Not determined2814034861420004Mouse
4142343Moen2_mmodifier of engrailed QTL 2 (mouse)Not determined192023431454234461Mouse
1302123Tlsr8_mthymic lymphoma suppressor region 8 (mouse)Not determined192513600242388916Mouse
4142406Pbctlp1_mperipheral blood cytotoxic T lymphocyte percentage 1 (mouse)Not determined132875174Mouse
1300904Chab5_mcholesterol absorption 5 (mouse)Not determined19165376435653927Mouse
26884385Skwq14_mskull length QTL 14, 16 week (mouse)19325000035877400Mouse
1301800Faq10_mfluctuating asymmetry QTL 10 (mouse)Not determined19332321637323348Mouse
1300591Pas3_mpulmonary adenoma susceptibility 3 (mouse)Not determined19332321637323348Mouse
1302063Eae19_mexperimental allergic encephalomyelitis 19 (mouse)Not determined191829516252295381Mouse
1302126Skull26_mskull morphology 26 (mouse)Not determined19332321637323348Mouse
1301228Iba4_minduction of brown adipocytes 4 (mouse)Not determined19930571543305821Mouse

Markers in Region
RH128654  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381928,966,450 - 28,966,641UniSTSGRCm38
MGSCv371929,040,940 - 29,041,131UniSTSGRCm37
Celera1929,741,688 - 29,741,879UniSTS
Cytogenetic Map19C1UniSTS
AW122618  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381928,966,613 - 28,966,755UniSTSGRCm38
MGSCv371929,041,103 - 29,041,245UniSTSGRCm37
Celera1929,741,851 - 29,741,993UniSTS
Cytogenetic Map19C1UniSTS
Whitehead/MRC_RH19299.9UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000045674   ⟹   ENSMUSP00000047776
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1928,941,353 - 28,944,211 (+)Ensembl
GRCm38.p6 Ensembl1928,963,953 - 28,966,811 (+)Ensembl
RefSeq Acc Id: NM_028922   ⟹   NP_083198
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391928,941,320 - 28,944,201 (+)NCBI
GRCm381928,963,920 - 28,966,801 (+)ENTREZGENE
MGSCv371929,038,410 - 29,041,291 (+)RGD
Celera1929,739,158 - 29,742,039 (+)RGD
cM Map19 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_083198 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH52412 (Get FASTA)   NCBI Sequence Viewer  
  BAB30313 (Get FASTA)   NCBI Sequence Viewer  
  EDL41663 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000047776
  ENSMUSP00000047776.3
GenBank Protein Q9D4F2 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_083198   ⟸   NM_028922
- UniProtKB: Q9D4F2 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000047776   ⟸   ENSMUST00000045674

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9D4F2-F1-model_v2 AlphaFold Q9D4F2 1-292 view protein structure

Promoters
RGD ID:13679190
Promoter ID:EPDNEW_M23744
Type:initiation region
Name:Plpp6_1
Description:Mus musculus phospholipid phosphatase 6 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381928,963,949 - 28,964,009EPDNEW
RGD ID:6830317
Promoter ID:MM_KWN:26773
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   BoneMarrow_0Hour,   BoneMarrow_4Hour,   Spleen
Transcripts:NM_028922
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361929,038,219 - 29,038,719 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1921661 AgrOrtholog
Ensembl Genes ENSMUSG00000040105 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000045674 ENTREZGENE
  ENSMUST00000045674.4 UniProtKB/Swiss-Prot
Gene3D-CATH Phosphatidic acid phosphatase type 2/haloperoxidase UniProtKB/Swiss-Prot
InterPro P_Acid_Pase_2/haloperoxi_sf UniProtKB/Swiss-Prot
  P_Acid_Pase_2/haloperoxidase UniProtKB/Swiss-Prot
KEGG Report mmu:74411 UniProtKB/Swiss-Prot
MGD MGI:1921661 ENTREZGENE
NCBI Gene 74411 ENTREZGENE
PANTHER PHOSPHOLIPID PHOSPHATASE 6 UniProtKB/Swiss-Prot
  SPHINGOSINE-1-PHOSPHATE PHOSPHOHYDROLASE UniProtKB/Swiss-Prot
Pfam PAP2 UniProtKB/Swiss-Prot
PhenoGen Plpp6 PhenoGen
SMART acidPPc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48317 UniProtKB/Swiss-Prot
UniProt PLPP6_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-17 Plpp6  phospholipid phosphatase 6  Ppapdc2  phosphatidic acid phosphatase type 2 domain containing 2  Symbol and/or name change 5135510 APPROVED