Serpina3n (serine (or cysteine) peptidase inhibitor, clade A, member 3N) - Rat Genome Database

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Gene: Serpina3n (serine (or cysteine) peptidase inhibitor, clade A, member 3N) Mus musculus
Analyze
Symbol: Serpina3n
Name: serine (or cysteine) peptidase inhibitor, clade A, member 3N
RGD ID: 731762
MGI Page MGI
Description: Predicted to enable serine-type endopeptidase inhibitor activity. Acts upstream of or within response to bacterium; response to cytokine; and response to peptide hormone. Located in extracellular region. Is expressed in nervous system; sensory organ; skeleton; thymus primordium; and urinary system. Human ortholog(s) of this gene implicated in adult respiratory distress syndrome; chronic obstructive pulmonary disease; cystic fibrosis; and vasculitis. Orthologous to human SERPINA3 (serpin family A member 3).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: alpha-1 antiproteinase; ant; antitrypsin; serine (or cysteine) proteinase inhibitor, clade A, member 3N; serine protease inhibitor 2-2; serine protease inhibitor A3N; serpin A3N; Spi; Spi2-2; Spi2.2; Spi2/e; Spi2/eb.4
RGD Orthologs
Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912104,372,967 - 104,380,588 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12104,372,988 - 104,380,588 (+)EnsemblGRCm39 Ensembl
GRCm3812104,406,646 - 104,414,334 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12104,406,729 - 104,414,329 (+)EnsemblGRCm38mm10GRCm38
MGSCv3712105,644,918 - 105,652,539 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612104,807,805 - 104,815,375 (+)NCBIMGSCv36mm8
Celera12105,637,386 - 105,645,008 (+)NCBICelera
Cytogenetic Map12ENCBI
cM Map1254.17NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(1->4)-beta-D-glucan  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP)
acetamide  (ISO)
acrylamide  (ISO)
aflatoxin B1  (EXP)
aldehydo-D-glucose  (EXP)
ammonium chloride  (ISO)
benzo[a]pyrene  (EXP,ISO)
bexarotene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
cadmium dichloride  (ISO)
carbon nanotube  (EXP)
carnosic acid  (EXP)
chloroquine  (ISO)
clofibrate  (EXP,ISO)
clothianidin  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
corticosterone  (ISO)
crocidolite asbestos  (EXP)
cyclosporin A  (ISO)
D-glucose  (EXP)
dexamethasone  (EXP)
dextran sulfate  (EXP)
diclofenac  (EXP,ISO)
dioxygen  (EXP)
diquat  (EXP)
diuron  (ISO)
doxorubicin  (EXP)
doxycycline  (EXP)
elemental selenium  (ISO)
fenofibrate  (ISO)
fenthion  (EXP)
flutamide  (ISO)
folic acid  (EXP)
fructose  (EXP)
furan  (ISO)
gentamycin  (ISO)
glafenine  (ISO)
glucose  (EXP)
glycidol  (ISO)
glycine betaine  (ISO)
glyphosate  (EXP)
graphene oxide  (EXP)
GW 4064  (EXP)
hydrazine  (ISO)
inulin  (EXP)
isoprenaline  (EXP)
methapyrilene  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
nefazodone  (ISO)
nitrofen  (ISO)
nitroglycerin  (ISO)
ozone  (EXP)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorohexanesulfonic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
phenacetin  (ISO)
phenylhydrazine  (ISO)
phosgene  (EXP)
piperonyl butoxide  (ISO)
pirinixic acid  (EXP,ISO)
potassium dichromate  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
progesterone  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
selenium atom  (ISO)
senecionine  (EXP)
silicon dioxide  (EXP)
sirolimus  (ISO)
sodium arsenite  (EXP)
sodium dichromate  (ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (EXP)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
trichloroethene  (EXP,ISO)
trimellitic anhydride  (EXP)
Triptolide  (ISO)
valproic acid  (EXP)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Protein abnormalities in adult respiratory distress syndrome, tuberculosis, and cystic fibrosis sera. Emmett M, etal., Proc Soc Exp Biol Med. 1987 Jan;184(1):74-82.
2. Alpha-1-antichymotrypsin expression in lung adenocarcinoma and its possible association with tumor progression. Higashiyama M, etal., Cancer. 1995 Oct 15;76(8):1368-76.
3. Plasma levels of alpha1-antichymotrypsin and secretory leukocyte proteinase inhibitor in healthy and chronic obstructive pulmonary disease (COPD) subjects with and without severe alpha1-antitrypsin deficiency. Hollander C, etal., BMC Pulm Med. 2007 Jan 29;7:1.
4. Association between alpha-1-antichymotrypsin polymorphism and susceptibility to chronic obstructive pulmonary disease. Ishii T, etal., Eur J Clin Invest. 2000 Jun;30(6):543-8.
5. Association of alpha(1)-antichymotrypsin deficiency with milder lung disease in patients with cystic fibrosis. Mahadeva R, etal., Thorax. 2001 Jan;56(1):53-8.
6. MGDs mouse GO annotations MGD data from the GO Consortium
7. Cardioprotection by a novel recombinant serine protease inhibitor in myocardial ischemia and reperfusion injury. Murohara T, etal., J Pharmacol Exp Ther. 1995 Sep;274(3):1246-53.
8. Alpha-1-antichymotrypsin is an effective inhibitor of pancreatitis-induced lung injury. O'Donovan DA, etal., Eur J Gastroenterol Hepatol. 1995 Sep;7(9):847-52.
9. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
10. A leucine-to-proline substitution causes a defective alpha 1-antichymotrypsin allele associated with familial obstructive lung disease. Poller W, etal., Genomics. 1993 Sep;17(3):740-3.
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. [Some acute phase proteins in children suffering from recurrent laryngeal papillomatosis]. Szydlowski J, etal., Otolaryngol Pol. 2005;59(4):505-9.
14. Expression of serine protease inhibitor 3 in ocular tissues in endotoxin-induced uveitis in rat. Takamiya A, etal., Invest Ophthalmol Vis Sci. 2001 Oct;42(11):2427-33.
15. Inflammation inhibitors were remarkably up-regulated in plasma of severe acute respiratory syndrome patients at progressive phase. Wan J, etal., Proteomics. 2006 May;6(9):2886-94.
Additional References at PubMed
PMID:1718822   PMID:12477932   PMID:12659817   PMID:15163632   PMID:15489334   PMID:15618518   PMID:15638460   PMID:15795238   PMID:16141197   PMID:17015688   PMID:18287559   PMID:21076990  
PMID:21267068   PMID:21677750   PMID:21873635   PMID:23012479   PMID:24006456   PMID:24172014   PMID:25299783   PMID:25753484   PMID:25915831   PMID:26624618   PMID:29720086   PMID:30304388  
PMID:30353127   PMID:32599075   PMID:32900484   PMID:33436521   PMID:33609775   PMID:33662018   PMID:33862275   PMID:34351428   PMID:34897996   PMID:35416570   PMID:36089165   PMID:36457151  
PMID:36625462   PMID:37422673   PMID:38175667  


Genomics

Comparative Map Data
Serpina3n
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912104,372,967 - 104,380,588 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12104,372,988 - 104,380,588 (+)EnsemblGRCm39 Ensembl
GRCm3812104,406,646 - 104,414,334 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12104,406,729 - 104,414,329 (+)EnsemblGRCm38mm10GRCm38
MGSCv3712105,644,918 - 105,652,539 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612104,807,805 - 104,815,375 (+)NCBIMGSCv36mm8
Celera12105,637,386 - 105,645,008 (+)NCBICelera
Cytogenetic Map12ENCBI
cM Map1254.17NCBI
Serpina3n
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86129,088,392 - 129,095,950 (+)NCBIGRCr8
mRatBN7.26123,323,623 - 123,331,181 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6123,323,629 - 123,332,433 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6123,454,436 - 123,462,011 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06123,749,728 - 123,757,302 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06123,120,847 - 123,128,422 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06128,073,344 - 128,080,878 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6127,941,526 - 128,080,889 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06137,283,367 - 137,290,901 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46128,461,775 - 128,469,309 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16128,465,521 - 128,473,056 (+)NCBI
Celera6120,800,865 - 120,808,399 (+)NCBICelera
Cytogenetic Map6q32NCBI

Variants

.
Variants in Serpina3n
220 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:311
Count of miRNA genes:249
Interacting mature miRNAs:265
Transcripts:ENSMUST00000021506
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142002Tbqt3_mtibia bone quality traits 3 (mouse)Not determined1235285496109936243Mouse
27226793Feml10_mfemur length 10, 5 week (mouse)1268346774113363620Mouse
4141738Tgq23_mtriglyceride QTL 23 (mouse)Not determined72112877106112877Mouse
1301926Adip6_madiposity 6 (mouse)Not determined1273887422107887526Mouse
1301689Skull18_mskull morphology 18 (mouse)Not determined1273887422107887526Mouse
13524842Ppiq10a_mprepulse inhibition QTL 10a (mouse)1277512220111512220Mouse
4141610Tailaq1_mtail length adjusted QTL 1 (mouse)Not determined80956708113383533Mouse
4142401Egq10_mearly growth QTL 10 (mouse)Not determined80956708113383533Mouse
4141335W6q10_mweight 6 weeks QTL 10 (mouse)Not determined80956708113383533Mouse
39128213Lwq23_mliver weight QTL 10 (mouse)1280956708113383533Mouse
13524849Ppiq11a_mprepulse inhibition QTL 11a (mouse)1280989143114989143Mouse
25823169Hrsq8_mhost response to SARS QTL 8, log titer (mouse)1281696245108495368Mouse
13524846Ppiq11_mprepulse inhibition QTL 11 (mouse)1282666396116666396Mouse
1301492Dbsty3_mdiabesity 3 (mouse)Not determined1283532075117532224Mouse
1301879Insq10_minsulin QTL 10 (mouse)Not determined1283532075117532224Mouse
1300883Ath21_matherosclerosis 21 (mouse)Not determined1285961579119961683Mouse
10412156Nociq3_mnociceptive sensitivity inflammatory QTL 3 (mouse)Not determined1286396075114831653Mouse
4142007Chlq17_mcirculating hormone level QTL 17 (mouse)Not determined1288052874120092757Mouse
1300545Lifespan3_mlife span 3 (mouse)Not determined1288052874120092757Mouse
1301308Prdt4_mprion disease incubation time 4 (mouse)Not determined1288308354120092757Mouse
5491194Mobq3_mmultigenic obesity QTL 3 (mouse)Not determined1289664071120092757Mouse
1301836Heal5_mwound healing/regeneration 5 (mouse)Not determined1289939031120092757Mouse
1301922Bbaa6_mB.burgdorferi-associated arthritis 6 (mouse)Not determined1290308268120092757Mouse
12910790Pwgrq7_mpre-weaning growth rate QTL 7 (mouse)1290937367108645308Mouse
10402491Dipa4_mdrug induced psychomotor activation 4 (mouse)Not determined1291222515120092757Mouse
10412192Bbaa27_mB.burgdorferi-associated arthritis 27 (mouse)Not determined1291254220107308393Mouse
12910532Nrq10a_mnoise-induced hearing loss resistant QTL 10a (mouse)1292750025120092757Mouse
12910533Nrq10_mnoise-induced hearing loss resistant QTL 10 (mouse)1292750025120092757Mouse
1357463Vtbt14_mvertebral trabecular bone trait 14 (mouse)Not determined1292936097120092757Mouse
1300973Abmm_mantibody mediated myocarditis (mouse)Not determined1293264461120092757Mouse
11039526Ccc1_mcolitis susceptibility in the Collaborative Cross 1 (mouse)1293528334111028223Mouse
1302177Dps2_mdelta power in slow-wave sleep 2 (mouse)Not determined1294146064120092757Mouse
1302138Im6_mimmunoregulatory 6 (mouse)Not determined1296860337120092757Mouse
1301269Sluc12_msusceptibility to lung cancer 12 (mouse)Not determined1296860337120092757Mouse
10412075Nils1_mneointima lesion size 1 (mouse)Not determined12102024665120092757Mouse
25394546Skmw76_mskeletal muscle weight 76, TA (mouse)12102593095106941888Mouse


Expression


Sequence


RefSeq Acc Id: ENSMUST00000021506   ⟹   ENSMUSP00000021506
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl12104,372,988 - 104,380,588 (+)Ensembl
GRCm38.p6 Ensembl12104,406,729 - 104,414,329 (+)Ensembl
RefSeq Acc Id: NM_009252   ⟹   NP_033278
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3912104,372,967 - 104,380,588 (+)NCBI
GRCm3812104,406,708 - 104,414,329 (+)NCBI
MGSCv3712105,644,918 - 105,652,539 (+)RGD
Celera12105,637,386 - 105,645,008 (+)RGD
cM Map12 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_033278 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA40130 (Get FASTA)   NCBI Sequence Viewer  
  AAH13651 (Get FASTA)   NCBI Sequence Viewer  
  EDL18789 (Get FASTA)   NCBI Sequence Viewer  
  EDL18790 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000021506
  ENSMUSP00000021506.6
GenBank Protein Q91WP6 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_033278   ⟸   NM_009252
- Peptide Label: precursor
- UniProtKB: Q91WP6 (UniProtKB/Swiss-Prot),   Q62258 (UniProtKB/Swiss-Prot),   G3X8T9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000021506   ⟸   ENSMUST00000021506
Protein Domains
SERPIN

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q91WP6-F1-model_v2 AlphaFold Q91WP6 1-418 view protein structure

Promoters
RGD ID:8679142
Promoter ID:EPDNEW_M17602
Type:multiple initiation site
Name:Serpina3n_1
Description:Mus musculus serine peptidase inhibitor, clade A, member 3N ,mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3812104,406,715 - 104,406,775EPDNEW
RGD ID:6823399
Promoter ID:MM_KWN:12608
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:NM_009252
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3612105,644,656 - 105,645,156 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:105045 AgrOrtholog
Ensembl Genes ENSMUSG00000021091 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000021506 ENTREZGENE
  ENSMUST00000021506.6 UniProtKB/TrEMBL
Gene3D-CATH 2.30.39.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.497.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Serpin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Serpin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Serpin_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Serpin_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Serpin_sf_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Serpin_sf_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:20716 UniProtKB/TrEMBL
MGD MGI:105045 ENTREZGENE
NCBI Gene 20716 ENTREZGENE
PANTHER PTHR11461 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SERINE PROTEASE INHIBITOR A3N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Serpin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Serpina3n PhenoGen
PROSITE SERPIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SERPIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56574 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt G3X8T9 ENTREZGENE, UniProtKB/TrEMBL
  Q62258 ENTREZGENE
  Q91WP6 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q62258 UniProtKB/Swiss-Prot