Icos (inducible T cell co-stimulator) - Rat Genome Database

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Gene: Icos (inducible T cell co-stimulator) Mus musculus
Analyze
Symbol: Icos
Name: inducible T cell co-stimulator
RGD ID: 732863
MGI Page MGI
Description: Predicted to be involved in T cell costimulation; T cell tolerance induction; and cell-cell adhesion. Located in external side of plasma membrane. Is integral component of plasma membrane. Used to study common variable immunodeficiency. Human ortholog(s) of this gene implicated in celiac disease; common variable immunodeficiency; and immunoglobulin alpha deficiency. Orthologous to human ICOS (inducible T cell costimulator); PARTICIPATES IN primary immunodeficiency pathway; T cell receptor signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-diaminodiphenylmethane.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: activation-inducible lymphocyte immunomediatory molecule; AILIM; CCLP; CD28 and CTLA-4-like protein; CD28-related protein 1; CRP-1; H4; inducible T-cell co-stimulator; inducible T-cell costimulator; Ly115
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39160,999,909 - 61,039,481 (+)NCBIGRCm39mm39
GRCm39 Ensembl161,017,086 - 61,039,479 (+)Ensembl
GRCm38160,960,773 - 61,000,322 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl160,977,927 - 61,000,320 (+)EnsemblGRCm38mm10GRCm38
MGSCv37161,034,758 - 61,057,164 (+)NCBIGRCm37mm9NCBIm37
MGSCv36160,922,469 - 60,943,665 (+)NCBImm8
Celera161,493,037 - 61,515,464 (+)NCBICelera
Cytogenetic Map1C2NCBI
cM Map130.6NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal B cell number  (IAGP)
abnormal B cell physiology  (IAGP)
abnormal B cell selection  (IAGP)
abnormal CD4-positive, alpha-beta T cell physiology  (IAGP)
abnormal class switch recombination  (IAGP)
abnormal cytokine level  (IAGP)
abnormal cytokine secretion  (IAGP)
abnormal immune system physiology  (IAGP)
abnormal immunoglobulin level  (IAGP)
abnormal interferon level  (IAGP)
abnormal interleukin level  (IAGP)
abnormal interleukin secretion  (IAGP)
abnormal leukocyte cell number  (IAGP)
abnormal memory B cell number  (IAGP)
abnormal NK cell physiology  (IAGP)
abnormal Peyer's patch germinal center morphology  (IAGP)
abnormal response to infection  (IAGP)
abnormal small intestine morphology  (IAGP)
abnormal spleen germinal center morphology  (IAGP)
abnormal spleen morphology  (IAGP)
abnormal T cell differentiation  (IAGP)
abnormal T cell physiology  (IAGP)
abnormal T-helper 2 physiology  (IAGP)
decreased anti-insulin autoantibody level  (IAGP)
decreased autoantibody level  (IAGP)
decreased CD4-positive, alpha beta T cell number  (IAGP)
decreased circulating interferon-gamma level  (IAGP)
decreased circulating interleukin-4 level  (IAGP)
decreased germinal center B cell number  (IAGP)
decreased IgA level  (IAGP)
decreased IgE level  (IAGP)
decreased IgG level  (IAGP)
decreased IgG1 level  (IAGP)
decreased IgG2a level  (IAGP)
decreased IgG2b level  (IAGP)
decreased IgG2c level  (IAGP)
decreased interferon-gamma secretion  (IAGP)
decreased interleukin-21 secretion  (IAGP)
decreased interleukin-4 secretion  (IAGP)
decreased interleukin-5 secretion  (IAGP)
decreased lymphoma incidence  (IAGP)
decreased pancreatic islet number  (IAGP)
decreased plasma cell number  (IAGP)
decreased spleen germinal center number  (IAGP)
decreased spleen germinal center size  (IAGP)
decreased susceptibility to autoimmune diabetes  (IAGP)
decreased T cell number  (IAGP)
decreased T cell proliferation  (IAGP)
increased IgG3 level  (IAGP)
increased plasma cell number  (IAGP)
increased susceptibility to experimental autoimmune encephalomyelitis  (IAGP)
increased T cell derived lymphoma incidence  (IAGP)
insulitis  (IAGP)
short tibia  (IEA)
small lymph nodes  (IAGP)
small Peyer's patches  (IAGP)
References

Additional References at PubMed
PMID:10349636   PMID:10617205   PMID:10657606   PMID:10760791   PMID:10880526   PMID:11006126   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11238604   PMID:11247636   PMID:11343121  
PMID:11343122   PMID:11343123   PMID:11429542   PMID:11489981   PMID:11707574   PMID:11723074   PMID:11735222   PMID:11801630   PMID:12039907   PMID:12044964   PMID:12097399   PMID:12145647  
PMID:12244160   PMID:12370365   PMID:12432568   PMID:12456021   PMID:12466851   PMID:12477932   PMID:12538658   PMID:12538664   PMID:12594252   PMID:12594849   PMID:12645936   PMID:12717187  
PMID:12847246   PMID:12853164   PMID:12960306   PMID:14599850   PMID:14615582   PMID:14634147   PMID:15128772   PMID:15368302   PMID:15489334   PMID:15514586   PMID:15629449   PMID:15699103  
PMID:15699127   PMID:15728513   PMID:15809349   PMID:15880041   PMID:15917267   PMID:15941568   PMID:15956289   PMID:15972646   PMID:15994233   PMID:16081804   PMID:16141072   PMID:16141073  
PMID:16200068   PMID:16212904   PMID:16227984   PMID:16300749   PMID:16301634   PMID:16301640   PMID:16380473   PMID:16428752   PMID:16500623   PMID:16616645   PMID:16635747   PMID:16724117  
PMID:16751384   PMID:16783640   PMID:16880206   PMID:16887998   PMID:16982935   PMID:16990558   PMID:17014982   PMID:17039566   PMID:17039567   PMID:17114448   PMID:17549732   PMID:17635872  
PMID:17889619   PMID:17986443   PMID:18172933   PMID:18178815   PMID:18250436   PMID:18250437   PMID:18292537   PMID:18310064   PMID:18390703   PMID:18390727   PMID:18606653   PMID:18684917  
PMID:18976292   PMID:18981236   PMID:18988696   PMID:19008373   PMID:19050242   PMID:19098919   PMID:19194830   PMID:19217324   PMID:19249753   PMID:19291374   PMID:19299705   PMID:19448155  
PMID:19570826   PMID:19603141   PMID:19608860   PMID:19646680   PMID:19888475   PMID:19889730   PMID:19914290   PMID:19915142   PMID:20022728   PMID:20544729   PMID:20624644   PMID:20691615  
PMID:21267068   PMID:21337542   PMID:21364749   PMID:21421907   PMID:21447398   PMID:21544030   PMID:21636296   PMID:21677750   PMID:21873635   PMID:21925472   PMID:22018468   PMID:22154192  
PMID:22156342   PMID:22172879   PMID:22227569   PMID:22231701   PMID:22532671   PMID:22547698   PMID:22585681   PMID:22661090   PMID:22700722   PMID:22815292   PMID:22949644   PMID:23285133  
PMID:23319295   PMID:23498793   PMID:23583643   PMID:23619696   PMID:23729441   PMID:23926322   PMID:23967339   PMID:24100657   PMID:24378539   PMID:24486724   PMID:24778280   PMID:24820310  
PMID:25088770   PMID:25347065   PMID:25436971   PMID:25464855   PMID:25576595   PMID:25646266   PMID:25692700   PMID:25754933   PMID:25769613   PMID:25884798   PMID:25918344   PMID:26049110  
PMID:26109645   PMID:26198302   PMID:26249010   PMID:26410627   PMID:26459508   PMID:26667167   PMID:26767258   PMID:27022145   PMID:27135603   PMID:27235509   PMID:27296665   PMID:27760760  
PMID:27812214   PMID:28002569   PMID:28297661   PMID:28424681   PMID:28488693   PMID:29352114   PMID:29378030   PMID:29581356   PMID:29676593   PMID:30076099   PMID:30523347   PMID:30642977  
PMID:30655308   PMID:30718297   PMID:30926234   PMID:31283790   PMID:31413107   PMID:31466995   PMID:31978191   PMID:32160524   PMID:32289155   PMID:33495237  


Genomics

Comparative Map Data
Icos
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39160,999,909 - 61,039,481 (+)NCBIGRCm39mm39
GRCm39 Ensembl161,017,086 - 61,039,479 (+)Ensembl
GRCm38160,960,773 - 61,000,322 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl160,977,927 - 61,000,320 (+)EnsemblGRCm38mm10GRCm38
MGSCv37161,034,758 - 61,057,164 (+)NCBIGRCm37mm9NCBIm37
MGSCv36160,922,469 - 60,943,665 (+)NCBImm8
Celera161,493,037 - 61,515,464 (+)NCBICelera
Cytogenetic Map1C2NCBI
cM Map130.6NCBI
ICOS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2203,936,763 - 203,961,577 (+)EnsemblGRCh38hg38GRCh38
GRCh382203,936,763 - 203,961,577 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372204,801,486 - 204,826,300 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362204,509,748 - 204,534,545 (+)NCBINCBI36hg18NCBI36
Build 342204,627,008 - 204,651,802NCBI
Celera2198,556,278 - 198,581,105 (+)NCBI
Cytogenetic Map2q33.2NCBI
HuRef2196,648,626 - 196,673,332 (+)NCBIHuRef
CHM1_12204,807,968 - 204,832,793 (+)NCBICHM1_1
Icos
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2962,368,075 - 62,406,900 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl962,383,832 - 62,405,672 (+)Ensembl
Rnor_6.0967,748,157 - 67,786,808 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl967,763,897 - 67,785,580 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0967,563,758 - 67,599,683 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera959,806,431 - 59,827,774 (+)NCBICelera
Cytogenetic Map9q32NCBI
Icos
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545710,934,341 - 10,952,404 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545710,934,390 - 10,952,318 (-)NCBIChiLan1.0ChiLan1.0
ICOS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12B209,307,938 - 209,332,734 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B209,307,938 - 209,332,734 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02B91,168,998 - 91,193,808 (+)NCBIMhudiblu_PPA_v0panPan3
ICOS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13712,663,839 - 12,735,266 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3712,670,999 - 12,733,458 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3713,596,013 - 13,616,605 (+)NCBI
ROS_Cfam_1.03712,600,441 - 12,671,981 (+)NCBI
UMICH_Zoey_3.13712,606,503 - 12,627,090 (+)NCBI
UNSW_CanFamBas_1.03712,569,911 - 12,590,566 (+)NCBI
UU_Cfam_GSD_1.03712,571,149 - 12,591,783 (+)NCBI
Icos
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303160,927,573 - 160,937,186 (+)NCBI
SpeTri2.0NW_004936631562,650 - 572,263 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ICOS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15107,350,203 - 107,370,123 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115107,350,253 - 107,370,123 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215118,697,582 - 118,717,451 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ICOS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11089,706,755 - 89,732,600 (+)NCBI
ChlSab1.1 Ensembl1089,726,489 - 89,732,944 (+)Ensembl
Vero_WHO_p1.0NW_023666040109,655,109 - 109,680,201 (-)NCBI
Icos
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476512,351,695 - 12,417,847 (-)NCBI

Position Markers
AB023132  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38160,997,799 - 60,997,947UniSTSGRCm38
MGSCv37161,054,643 - 61,054,791UniSTSGRCm37
Celera161,512,943 - 61,513,091UniSTS
Cytogenetic Map1C2UniSTS
cM Map132.0UniSTS
Whitehead/MRC_RH1886.08UniSTS
Icos  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38160,993,935 - 60,994,671UniSTSGRCm38
MGSCv37161,050,779 - 61,051,515UniSTSGRCm37
Celera161,509,075 - 61,509,811UniSTS
Cytogenetic Map1C2UniSTS
cM Map132.0UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13824984Twq5_mtestis weight QTL 5 (mouse)13000000185000000Mouse
1357475w3q13_mweight 3 weeks QTL 13 (mouse)Not determined12307051073937756Mouse
11100001Col4a1m1_mcollagen, type IV, alpha 1 modifier 1 (mouse)12551111062907723Mouse
1357822Lvrq3_mliver weight QTL 3 (mouse)Not determined13472105773937756Mouse
1357759W3q12_mweight 3 weeks QTL 12 (mouse)Not determined13472105773937756Mouse
1357651Lgq5_mlate growth QTL 5 (mouse)Not determined13472105773937756Mouse
1357506W10q6_mweight 10 weeks QTL 6 (mouse)Not determined13472105773937756Mouse
1357524W6q14_mweight 6 weeks QTL 14 (mouse)Not determined13472105773937756Mouse
1357824Estoq4_membryo survival total QTL 4 (mouse)Not determined13472105773937756Mouse
39128207Lwq16_mliver weight QTL 16 (mouse)13472105773937756Mouse
1357753Kidq2_mkidney weight QTL 2 (mouse)Not determined134721057150318120Mouse
1357488Splq3_mspleen weight QTL 3 (mouse)Not determined134721057150318120Mouse
1558860W10q7_mweight 10 weeks QTL 7 (mouse)Not determined134721057150318120Mouse
1301954Lrnx11_mlearning-contextual 11 (mouse)Not determined13909372774477206Mouse
1357721Sle17_msystematic lupus erythematosus susceptibility 17 (mouse)Not determined139093727126517573Mouse
12910780Pwgrq11_mpost-weaning growth rate QTL 11 (mouse)14082884867231097Mouse
12910786Pwgrq10_mpost-weaning growth rate QTL 10 (mouse)14082884867231097Mouse
12910788Pwgrq9_mpost-weaning growth rate QTL 9 (mouse)14082884867231097Mouse
1301166Thypr2_mthymocyte proliferative response 2 (mouse)Not determined14123396575234112Mouse
18182931Metl1_mmetabolite locus 1, pyridoxate (mouse)14123624075236240Mouse
4141032Wbcc1_mwhite blood cell count 1 (mouse)Not determined4222050876220508Mouse
1301714Vertcling_mvertical clinging (mouse)Not determined14289887276899008Mouse
12879917Shm3_msperm head morphology 3 (mouse)14414774462907723Mouse
1558855Eae30_mexperimental allergic encephalomyelitis susceptibility 30 (mouse)Not determined14537861372935898Mouse
1301722Cia9_mcollagen induced arthritis QTL 9 (mouse)Not determined145744740189571420Mouse
1301670Ssta1_msusceptibility to Salmonella typhimurium antigens 1 (mouse)Not determined14590759679907723Mouse
1301225Sle7_msystematic lupus erythematosus susceptibility 7 (mouse)Not determined14681553180815680Mouse
1301616Yaa2_mY-linked autoimmune acceleration 2 (mouse)Not determined14681553180815680Mouse
1558905Gct7_mgranulosa cell tumorigenesis 7 (mouse)Not determined14731073581310854Mouse
1558822Vas1_mautoimmune vasitis resistance 1 (mouse)Not determined14884984782850051Mouse
1301211Bbaa11_mB.burgdorferi-associated arthritis 11 (mouse)Not determined14884984782850051Mouse
1301430Cdcs2_mcytokine deficiency colitis susceptibility 2 (mouse)Not determined14885318682853326Mouse
10043965Obq24_mobesity QTL 24 (mouse)Not determined15085105784851057Mouse
4141305Tgq9_mtriglyceride QTL 9 (mouse)Not determined5138244685382446Mouse
4142307Shali1_msurvival time to hyperoxic acute lung injury 1 (mouse)Not determined5192486670367430Mouse
4142291Aec2_mautoimmune exocrinopathy 2 (mouse)Not determined52418578182423027Mouse
1357741Nidd5k_mNidd5 on KK-A<y> (mouse)Not determined15593578989935898Mouse
1357505Vtbt1_mvertebral trabecular bone trait 1 (mouse)Not determined15622705590227201Mouse
4142467Wbcq1_mwhite blood cell quantitative locus 1 (mouse)Not determined15622705590227201Mouse
1301933Insq6_minsulin QTL 6 (mouse)Not determined15668776390687918Mouse
1558717Ses1a_msalmonella enteritidis susceptibility 1a (mouse)Not determined15668776390687918Mouse
4141724Idd5.1_minsulin dependent diabetes susceptibility 5.1 (mouse)Not determined5768911762907723Mouse
14746998Mancz1_mmandible centroid size 1 (mouse)15790219291902192Mouse
14747009Manh49_mmandible shape 49 (mouse)15790219291902192Mouse
1300746Skl1_mskeletal size (tail length) 1 (mouse)Not determined15795281891952921Mouse
1357679Egrm1_mearly growth rate, maternal effect 1 (mouse)Not determined15795281891952921Mouse
1301162Skull1_mskull morphology 1 (mouse)Not determined15795281891952921Mouse
1301444Alcw5_malcohol withdrawal 5 (mouse)Not determined15857254792572799Mouse
1301667Lxw5_mlupus BXSB x NZW 5 (mouse)Not determined15857254792572799Mouse

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir101ammu-miR-101a-3pMirtarbaseexternal_infoqRT-PCRFunctional MTI (Weak)18172933

Predicted Target Of
Summary Value
Count of predictions:904
Count of miRNA genes:529
Interacting mature miRNAs:634
Transcripts:ENSMUST00000027162, ENSMUST00000102827
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_017480 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006496138 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006496139 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006496140 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB023132 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF216748 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF257230 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH010217 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI451625 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ250559 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK030827 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL596283 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL645744 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL663047 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB850356 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC034852 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466548 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR936839 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GQ420691 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GQ420694 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000027162   ⟹   ENSMUSP00000027162
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl161,017,086 - 61,034,956 (+)Ensembl
GRCm38.p6 Ensembl160,977,927 - 60,995,797 (+)Ensembl
RefSeq Acc Id: ENSMUST00000102827   ⟹   ENSMUSP00000099891
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl161,017,086 - 61,039,479 (+)Ensembl
GRCm38.p6 Ensembl160,977,927 - 61,000,320 (+)Ensembl
RefSeq Acc Id: NM_017480   ⟹   NP_059508
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39161,017,073 - 61,039,479 (+)NCBI
GRCm38160,977,914 - 61,000,320 (+)NCBI
MGSCv37161,034,758 - 61,057,164 (+)RGD
Celera161,493,037 - 61,515,464 (+)RGD
cM Map1 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006496138   ⟹   XP_006496201
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39160,999,909 - 61,039,481 (+)NCBI
GRCm38160,960,773 - 61,000,320 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006496139   ⟹   XP_006496202
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39160,999,909 - 61,039,481 (+)NCBI
GRCm38160,960,773 - 61,000,320 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006496140   ⟹   XP_006496203
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39161,028,644 - 61,039,481 (+)NCBI
GRCm38160,989,485 - 61,000,322 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_059508   ⟸   NM_017480
- Peptide Label: precursor
- UniProtKB: Q9WVS0 (UniProtKB/Swiss-Prot),   Q3V3X2 (UniProtKB/TrEMBL),   Q5SUZ7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006496201   ⟸   XM_006496138
- Peptide Label: isoform X1
- UniProtKB: Q9WVS0 (UniProtKB/Swiss-Prot),   Q5SUZ7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006496202   ⟸   XM_006496139
- Peptide Label: isoform X1
- UniProtKB: Q9WVS0 (UniProtKB/Swiss-Prot),   Q5SUZ7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006496203   ⟸   XM_006496140
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSMUSP00000027162   ⟸   ENSMUST00000027162
RefSeq Acc Id: ENSMUSP00000099891   ⟸   ENSMUST00000102827
Protein Domains
Ig-like V-type   IGv

Promoters
RGD ID:6873890
Promoter ID:EPDNEW_M396
Type:initiation region
Name:Icos_1
Description:Mus musculus inducible T cell co-stimulator , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38160,977,914 - 60,977,974EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1858745 AgrOrtholog
Ensembl Genes ENSMUSG00000026009 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000027162 UniProtKB/TrEMBL
  ENSMUSP00000099891 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000027162 UniProtKB/TrEMBL
  ENSMUST00000102827 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ICOS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_V-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:54167 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1858745 ENTREZGENE
NCBI Gene 54167 ENTREZGENE
PANTHER PTHR20904 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam V-set_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Icos PhenoGen
UniProt A2A6A6_MOUSE UniProtKB/TrEMBL
  A2A6A7_MOUSE UniProtKB/TrEMBL
  D0E8G6_MOUSE UniProtKB/TrEMBL
  ICOS_MOUSE UniProtKB/Swiss-Prot
  Q3V3X2 ENTREZGENE, UniProtKB/TrEMBL
  Q5SUZ7 ENTREZGENE, UniProtKB/TrEMBL
  Q5SUZ8_MOUSE UniProtKB/TrEMBL
  Q9WVS0 ENTREZGENE
UniProt Secondary Q9JL17 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-02-07 Icos  inducible T cell co-stimulator  Icos  inducible T-cell co-stimulator  Symbol and/or name change 5135510 APPROVED