Hhex (hematopoietically expressed homeobox) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Hhex (hematopoietically expressed homeobox) Mus musculus
Analyze
Symbol: Hhex
Name: hematopoietically expressed homeobox
RGD ID: 731855
MGI Page MGI
Description: Enables several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; HMG box domain binding activity; and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including negative regulation of angiogenesis; negative regulation of transcription by RNA polymerase II; and regulation of signal transduction. Acts upstream of or within several processes, including forebrain development; hepaticobiliary system development; and leukocyte differentiation. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; early conceptus; gut; liver and biliary system; and metanephros. Orthologous to human HHEX (hematopoietically expressed homeobox).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hematopoietically expressed homeobox, related sequence 2; hematopoietically-expressed homeobox protein Hhex; Hex; Hex1; Hhex-r; Hhex-rs2; homeobox protein HEX; homeobox protein PRH; mHex; Pr; Prh; Prhx
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391937,423,289 - 37,429,179 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1937,423,258 - 37,429,179 (+)EnsemblGRCm39 Ensembl
GRCm381937,434,841 - 37,440,731 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1937,434,810 - 37,440,731 (+)EnsemblGRCm38mm10GRCm38
MGSCv371937,509,331 - 37,515,221 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361937,499,985 - 37,505,875 (+)NCBIMGSCv36mm8
Celera1938,221,629 - 38,227,525 (+)NCBICelera
Cytogenetic Map19C2NCBI
cM Map1932.28NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
17beta-estradiol  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2-palmitoylglycerol  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP)
5-azacytidine  (ISO)
acetaldehyde  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (ISO)
azathioprine  (ISO)
belinostat  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
Benzo[ghi]perylene  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
buspirone  (ISO)
buta-1,3-diene  (EXP)
cadmium atom  (EXP)
cadmium dichloride  (EXP)
carbamazepine  (EXP)
CGP 52608  (ISO)
chenodeoxycholic acid  (EXP,ISO)
chlorpyrifos  (EXP)
choline  (EXP)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
diazinon  (ISO)
diclofenac  (EXP)
dimethylarsinic acid  (EXP)
dorsomorphin  (ISO)
entinostat  (ISO)
epoxiconazole  (EXP)
ethyl methanesulfonate  (ISO)
fipronil  (ISO)
flusilazole  (EXP)
folic acid  (EXP)
furan  (ISO)
GW 4064  (EXP)
inositol  (EXP)
L-methionine  (EXP)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
lithium atom  (EXP)
lithium hydride  (EXP)
metformin  (ISO)
methotrexate  (EXP)
methylarsonic acid  (EXP)
methylmercury(1+)  (ISO)
mitomycin C  (ISO)
nefazodone  (ISO)
nickel atom  (ISO)
nimesulide  (ISO)
ozone  (EXP)
paracetamol  (EXP,ISO)
perfluorobutanesulfonic acid  (ISO)
perfluorobutyric acid  (ISO)
perfluorododecanoic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorohexanoic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
perfluoroundecanoic acid  (ISO)
phenformin  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
quercetin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
sevoflurane  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (EXP)
sodium arsenite  (EXP,ISO)
Soman  (ISO)
sulforaphane  (ISO)
testosterone  (EXP)
tetracycline  (ISO)
titanium dioxide  (EXP)
trichloroethene  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
valproic acid  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ morphogenesis  (IMP)
anterior/posterior pattern specification  (IMP)
B cell differentiation  (IMP)
cell differentiation  (IBA,ISO)
common bile duct development  (IMP)
DNA conformation change  (ISO)
embryonic heart tube development  (IMP)
embryonic organ development  (IMP)
endoderm development  (IMP)
forebrain development  (IMP)
forebrain morphogenesis  (IMP)
gallbladder development  (IMP)
hemopoiesis  (IMP)
hepatic duct development  (IMP)
hepatoblast differentiation  (IMP)
hepatocyte differentiation  (IMP)
in utero embryonic development  (IMP)
interkinetic nuclear migration  (IMP)
liver development  (IMP)
morphogenesis of an epithelium  (IMP)
mRNA export from nucleus  (ISO)
multicellular organism growth  (IMP)
myeloid leukocyte differentiation  (IMP)
negative regulation of angiogenesis  (IDA,ISO)
negative regulation of cyclin-dependent protein serine/threonine kinase activity  (ISO)
negative regulation of DNA-templated transcription  (IDA,ISO)
negative regulation of transcription by RNA polymerase II  (IDA,ISO)
negative regulation of vascular endothelial growth factor receptor signaling pathway  (IDA,ISO)
Notch signaling pathway  (IDA)
pancreas development  (IMP)
poly(A)+ mRNA export from nucleus  (ISO)
positive regulation of canonical Wnt signaling pathway  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of Wnt signaling pathway  (IMP)
primary lung bud formation  (IMP)
primitive streak formation  (IGI,IMP)
protein localization to nucleus  (ISO)
regulation of cell population proliferation  (IMP)
regulation of DNA-templated transcription  (IEA)
regulation of leukocyte proliferation  (ISO)
regulation of transcription by RNA polymerase II  (IBA,IMP)
response to peptide hormone  (ISO)
signal transduction  (IMP)
thyroid gland development  (IMP)
tissue morphogenesis  (IMP)
vasculogenesis  (IMP)
Wnt signaling pathway  (IEA)

Cellular Component
cytoplasm  (IDA,ISO)
nucleus  (IDA,ISO)
protein-DNA complex  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal anterior definitive endoderm morphology  (IAGP)
abnormal anterior visceral endoderm morphology  (IAGP)
abnormal atrioventricular cushion morphology  (IAGP)
abnormal atrioventricular valve morphology  (IAGP)
abnormal bile duct development  (IAGP)
abnormal blood vessel morphology  (IAGP)
abnormal cardiac epithelial to mesenchymal transition  (IAGP)
abnormal conotruncal ridge morphology  (IAGP)
abnormal egg cylinder morphology  (IAGP)
abnormal embryo development  (IAGP)
abnormal extrahepatic bile duct morphology  (IAGP)
abnormal first pharyngeal arch morphology  (IAGP)
abnormal forebrain development  (IAGP)
abnormal forebrain morphology  (IAGP)
abnormal hepatic diverticulum morphology  (IAGP)
abnormal hepatic duct morphology  (IAGP)
abnormal hepatoblast migration  (IAGP)
abnormal hepatocyte morphology  (IAGP)
abnormal intrahepatic bile duct morphology  (IAGP)
abnormal liver bud morphology  (IAGP)
abnormal liver development  (IAGP)
abnormal liver morphology  (IAGP)
abnormal medial ganglionic eminence morphology  (IAGP)
abnormal monocyte differentiation  (IAGP)
abnormal myocardial trabeculae morphology  (IAGP)
abnormal nasal placode morphology  (IAGP)
abnormal optic stalk morphology  (IAGP)
abnormal optic vesicle formation  (IAGP)
abnormal pericardial cavity morphology  (IAGP)
abnormal primitive streak morphology  (IAGP)
abnormal survival  (IAGP)
abnormal telencephalon development  (IAGP)
abnormal thyroid gland development  (IAGP)
abnormal thyroid gland morphology  (IAGP)
abnormal vasculogenesis  (IAGP)
absent embryonic telencephalon  (IAGP)
absent forebrain  (IAGP)
absent gallbladder  (IAGP)
absent liver  (IAGP)
absent nasal placodes  (IAGP)
absent Rathke's pouch  (IAGP)
anophthalmia  (IAGP)
biliary cyst  (IAGP)
conotruncal ridge hyperplasia  (IAGP)
decreased forebrain size  (IAGP)
decreased heart right ventricle size  (IAGP)
double outlet right ventricle  (IAGP)
edema  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
embryonic lethality during organogenesis, incomplete penetrance  (IAGP)
fused first pharyngeal arch  (IAGP)
heart right ventricle outflow tract stenosis  (IAGP)
impaired hematopoiesis  (IAGP)
increased atrioventricular cushion size  (IAGP)
lethality throughout fetal growth and development, complete penetrance  (IAGP)
liver cyst  (IAGP)
liver hypoplasia  (IAGP)
pericardial edema  (IAGP)
prenatal lethality, complete penetrance  (IAGP)
preweaning lethality, incomplete penetrance  (IAGP)
rostral body truncation  (IAGP)
small embryonic telencephalon  (IAGP)
thin myocardium compact layer  (IAGP)
thin ventricular wall  (IAGP)
vascular smooth muscle hypoplasia  (IAGP)
ventricular septal defect  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. Getting your head around Hex and Hesx1: forebrain formation in mouse. Martinez-Barbera JP and Beddington RS, Int J Dev Biol 2001;45(1):327-36.
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. MGD IEA MGD IEA
5. HNF3beta and Lim1 interact in the visceral endoderm to regulate primitive streak formation and anterior-posterior polarity in the mouse embryo. Perea-Gomez A, etal., Development 1999 Oct;126(20):4499-511.
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. Mouse MP Annotation Import Pipeline RGD automated import pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8096636   PMID:8099440   PMID:9389666   PMID:9598343   PMID:9599004   PMID:10349636   PMID:10421635   PMID:10501975   PMID:10535967   PMID:10597256   PMID:10610183   PMID:10662781  
PMID:10673281   PMID:10767553   PMID:10804173   PMID:10804184   PMID:10887078   PMID:10974674   PMID:10985852   PMID:11002334   PMID:11027604   PMID:11042159   PMID:11044484   PMID:11076861  
PMID:11114168   PMID:11139473   PMID:11171400   PMID:11298452   PMID:11358868   PMID:11358869   PMID:11397001   PMID:11551904   PMID:11809759   PMID:11884616   PMID:11927540   PMID:11973269  
PMID:12091315   PMID:12194849   PMID:12270938   PMID:12351178   PMID:12381664   PMID:12384562   PMID:12431380   PMID:12447384   PMID:12460189   PMID:12466851   PMID:12477932   PMID:12522149  
PMID:12581525   PMID:12588764   PMID:12588852   PMID:12791650   PMID:12842913   PMID:12925589   PMID:12952897   PMID:14511481   PMID:14555989   PMID:14648878   PMID:14657239   PMID:14668413  
PMID:14681194   PMID:14736744   PMID:14761651   PMID:15004567   PMID:15013800   PMID:15084457   PMID:15142971   PMID:15183723   PMID:15215210   PMID:15261829   PMID:15302604   PMID:15459110  
PMID:15489334   PMID:15525667   PMID:15581879   PMID:15618518   PMID:15687261   PMID:15728128   PMID:15739227   PMID:15767668   PMID:15829518   PMID:15857913   PMID:15870281   PMID:15929941  
PMID:16026781   PMID:16141072   PMID:16141073   PMID:16256739   PMID:16291788   PMID:16364283   PMID:16368929   PMID:16397896   PMID:16481355   PMID:16537572   PMID:16564040   PMID:16582099  
PMID:16602821   PMID:16678776   PMID:16728477   PMID:16764824   PMID:16831833   PMID:16839541   PMID:16854221   PMID:16887818   PMID:16936074   PMID:16971476   PMID:17133501   PMID:17143861  
PMID:17274974   PMID:17341133   PMID:17350578   PMID:17389379   PMID:17580084   PMID:17609113   PMID:17634284   PMID:17936262   PMID:18171685   PMID:18224709   PMID:18287559   PMID:18498097  
PMID:18554416   PMID:18617531   PMID:18635606   PMID:18854136   PMID:18940732   PMID:18974875   PMID:19072826   PMID:19153222   PMID:19234065   PMID:19369401   PMID:19389367   PMID:19403103  
PMID:19410550   PMID:19605690   PMID:19619492   PMID:19706528   PMID:19805295   PMID:19877283   PMID:19913509   PMID:20028982   PMID:20059953   PMID:20153842   PMID:20211142   PMID:20346354  
PMID:20412781   PMID:20450902   PMID:20472829   PMID:20508035   PMID:20708584   PMID:20876643   PMID:20887958   PMID:20932939   PMID:21149574   PMID:21267068   PMID:21386911   PMID:21445260  
PMID:21454303   PMID:21862448   PMID:21873635   PMID:22383895   PMID:22412967   PMID:22589735   PMID:22669107   PMID:22698281   PMID:22711520   PMID:22939930   PMID:22988430   PMID:23085236  
PMID:23552073   PMID:23651855   PMID:23665349   PMID:23707896   PMID:23824574   PMID:23840778   PMID:23951403   PMID:24131634   PMID:24176640   PMID:24449835   PMID:24465765   PMID:24585688  
PMID:24736842   PMID:24952961   PMID:25220416   PMID:25283843   PMID:25446530   PMID:25472970   PMID:25536399   PMID:25664857   PMID:25910836   PMID:25968920   PMID:26494787   PMID:26534984  
PMID:26728554   PMID:26752640   PMID:26784346   PMID:26975355   PMID:27026076   PMID:27217206   PMID:27521049   PMID:27736991   PMID:28174238   PMID:28189604   PMID:28467430   PMID:28538179  
PMID:28577303   PMID:28838957   PMID:29138408   PMID:29168693   PMID:30006544   PMID:30504829   PMID:30959515   PMID:31308417   PMID:31792183   PMID:32090320   PMID:32433954   PMID:32439762  
PMID:32601467   PMID:33086067   PMID:33677034   PMID:34824237   PMID:35248949   PMID:35434453   PMID:35440748   PMID:35641029   PMID:35726782   PMID:35729116   PMID:35831318   PMID:38750011  
PMID:39055950  


Genomics

Comparative Map Data
Hhex
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391937,423,289 - 37,429,179 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1937,423,258 - 37,429,179 (+)EnsemblGRCm39 Ensembl
GRCm381937,434,841 - 37,440,731 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1937,434,810 - 37,440,731 (+)EnsemblGRCm38mm10GRCm38
MGSCv371937,509,331 - 37,515,221 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361937,499,985 - 37,505,875 (+)NCBIMGSCv36mm8
Celera1938,221,629 - 38,227,525 (+)NCBICelera
Cytogenetic Map19C2NCBI
cM Map1932.28NCBI
HHEX
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381092,689,955 - 92,695,647 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1092,689,955 - 92,695,647 (+)EnsemblGRCh38hg38GRCh38
GRCh371094,449,712 - 94,455,404 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361094,439,661 - 94,445,388 (+)NCBINCBI36Build 36hg18NCBI36
Build 341094,439,691 - 94,445,383NCBI
Celera1088,191,085 - 88,196,812 (+)NCBICelera
Cytogenetic Map10q23.33NCBI
HuRef1088,076,253 - 88,081,980 (+)NCBIHuRef
CHM1_11094,732,137 - 94,737,863 (+)NCBICHM1_1
T2T-CHM13v2.01093,569,602 - 93,575,294 (+)NCBIT2T-CHM13v2.0
Hhex
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81244,602,945 - 244,608,532 (+)NCBIGRCr8
mRatBN7.21235,190,455 - 235,196,042 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1235,190,455 - 235,196,042 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1243,576,013 - 243,581,585 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01250,507,808 - 250,513,395 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01243,345,997 - 243,351,584 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01256,101,994 - 256,107,581 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1256,101,903 - 256,107,649 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01263,583,988 - 263,589,575 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41241,736,542 - 241,742,129 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11241,926,133 - 241,931,721 (+)NCBI
Celera1232,281,249 - 232,286,836 (+)NCBICelera
Cytogenetic Map1q53NCBI
Hhex
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955425735,378 - 742,775 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955425737,506 - 742,775 (-)NCBIChiLan1.0ChiLan1.0
HHEX
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28104,725,043 - 104,730,830 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110104,730,394 - 104,736,144 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01089,433,402 - 89,439,137 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11092,947,373 - 92,952,992 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1092,947,373 - 92,952,992 (+)Ensemblpanpan1.1panPan2
HHEX
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1287,057,379 - 7,063,326 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl287,057,283 - 7,063,330 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha287,233,996 - 7,239,896 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0287,317,251 - 7,323,151 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl287,317,203 - 7,323,145 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1287,037,744 - 7,043,641 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0287,072,416 - 7,078,310 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0287,236,847 - 7,242,744 (+)NCBIUU_Cfam_GSD_1.0
Hhex
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721340,504,266 - 40,511,263 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366012,136,873 - 2,143,857 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366012,137,490 - 2,143,797 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HHEX
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14104,194,343 - 104,200,219 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114104,194,424 - 104,199,684 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214113,794,343 - 113,799,603 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HHEX
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1985,957,684 - 85,963,414 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl985,957,779 - 85,963,404 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604846,697,779 - 46,703,530 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hhex
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247373,897,871 - 3,904,083 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247373,897,907 - 3,903,828 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Hhex
211 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:817
Count of miRNA genes:447
Interacting mature miRNAs:528
Transcripts:ENSMUST00000025944, ENSMUST00000128184
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13506250Renmq1_mrenal mercury accumulation QTL 1 (mouse)192738559461385705Mouse
10412251Mnp_mmodifier of Niemann Pick type C1 (mouse)Not determined192023431454234461Mouse
1302170Tanidd1_mtally ho associated non-insulin dependednt diabetes mellitus 1 (mouse)Not determined193675259761420004Mouse
11039522Tbbr4_mTrypanosoma brucei brucei response 4 (mouse)19531332639313470Mouse
1301336Alcp23_malcohol preference locus 23 (mouse)Not determined191591260749912719Mouse
1558876W3q14_mweight 3 weeks QTL 14 (mouse)Not determined192231332653911504Mouse
1302019Pgia23_mproteoglycan induced arthritis 23 (mouse)Not determined19978745343787602Mouse
1301633Alcp24_malcohol preference locus 24 (mouse)Not determined191591260749912719Mouse
14928311Manh85_mmandible shape 85 (mouse)191191478945914789Mouse
1301639Stnn_mstriatal neuron number (mouse)Not determined193395195261420004Mouse
1301451Ath16_matherosclerosis 16 (mouse)Not determined192542691759427005Mouse
1300683Fembm7_mfemoral bone morphometry 7 (mouse)Not determined193014122461420004Mouse
4141659Pbwg20_mpostnatal body weight growth 20 (mouse)Not determined192137870555378928Mouse
4141019Tgq29_mtriglyceride QTL 29 (mouse)Not determined3459678661420004Mouse
1301942Pas13_mpulmonary adenoma susceptibility 13 (mouse)Not determined193014123161420004Mouse
10413881Moe2_mmodifier of epilepsy 2 (mouse)191492301648923138Mouse
1302004Lfp2_mlong free running period 2 (mouse)Not determined191829516252295381Mouse
12790634Ebm1_mEpidermolysis Bullosa modifier 1 (mouse)192498843958988439Mouse
1300856Nobq2_mNew Zealand obese QTL 2 (mouse)Not determined193089788061420004Mouse
4141138Femwf11_mfemur work to failure 11 (mouse)Not determined2814034861420004Mouse
13504736Ifvrq6_minfluenza virus resistance QTL 6 (mouse)193690291044913949Mouse
1301410Cd8mts6_mCD8 memory T cell subset 6 (mouse)Not determined193014123161420004Mouse
1301479Sluc1_msusceptibility to lung cancer 1 (mouse)Not determined193601694446761521Mouse
4142343Moen2_mmodifier of engrailed QTL 2 (mouse)Not determined192023431454234461Mouse
1302123Tlsr8_mthymic lymphoma suppressor region 8 (mouse)Not determined192513600242388916Mouse
1302063Eae19_mexperimental allergic encephalomyelitis 19 (mouse)Not determined191829516252295381Mouse
1301741Lith2_mlithogenic gene 2 (mouse)Not determined193299215861420004Mouse
1301228Iba4_minduction of brown adipocytes 4 (mouse)Not determined19930571543305821Mouse

Markers in Region
UniSTS:237933  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381937,439,809 - 37,439,996UniSTSGRCm38
MGSCv371937,514,299 - 37,514,486UniSTSGRCm37
Celera1938,226,587 - 38,226,790UniSTS
Cytogenetic Map19D1UniSTS
cM Map1947.5UniSTS
PMC141034P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381937,436,093 - 37,436,415UniSTSGRCm38
MGSCv371937,510,583 - 37,510,905UniSTSGRCm37
Celera1938,222,880 - 38,223,202UniSTS
Cytogenetic Map19D1UniSTS
cM Map1947.5UniSTS
AB017132  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381937,440,342 - 37,440,469UniSTSGRCm38
MGSCv371937,514,832 - 37,514,959UniSTSGRCm37
Celera1938,227,136 - 38,227,263UniSTS
Cytogenetic Map19D1UniSTS
cM Map1947.5UniSTS
Whitehead/MRC_RH19354.42UniSTS
Hhex  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map19D1UniSTS
cM Map1947.5UniSTS
Hhex  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map19D1UniSTS
Hhex  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map19D1UniSTS


Expression


Sequence


Ensembl Acc Id: ENSMUST00000025944   ⟹   ENSMUSP00000025944
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1937,423,258 - 37,429,179 (+)Ensembl
GRCm38.p6 Ensembl1937,434,810 - 37,440,731 (+)Ensembl
Ensembl Acc Id: ENSMUST00000128184   ⟹   ENSMUSP00000133688
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1937,425,187 - 37,429,120 (+)Ensembl
GRCm38.p6 Ensembl1937,436,739 - 37,440,672 (+)Ensembl
Ensembl Acc Id: ENSMUST00000237452
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1937,423,258 - 37,427,165 (+)Ensembl
GRCm38.p6 Ensembl1937,434,810 - 37,438,717 (+)Ensembl
RefSeq Acc Id: NM_008245   ⟹   NP_032271
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391937,423,289 - 37,429,179 (+)NCBI
GRCm381937,434,841 - 37,440,731 (+)ENTREZGENE
MGSCv371937,509,331 - 37,515,221 (+)RGD
Celera1938,221,629 - 38,227,525 (+)RGD
cM Map19 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_032271   ⟸   NM_008245
- UniProtKB: Q9CRV1 (UniProtKB/Swiss-Prot),   Q544N6 (UniProtKB/Swiss-Prot),   Q9R1X2 (UniProtKB/Swiss-Prot),   P43120 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000025944   ⟸   ENSMUST00000025944
Ensembl Acc Id: ENSMUSP00000133688   ⟸   ENSMUST00000128184
Protein Domains
Homeobox

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P43120-F1-model_v2 AlphaFold P43120 1-271 view protein structure

Promoters
RGD ID:13679388
Promoter ID:EPDNEW_M23843
Type:initiation region
Name:Hhex_1
Description:Mus musculus hematopoietically expressed homeobox , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381937,434,841 - 37,434,901EPDNEW
RGD ID:6830116
Promoter ID:MM_KWN:26966
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   ES_Cell,   Kidney,   Liver,   Lung,   Spleen
Transcripts:NM_008245
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361937,509,209 - 37,509,709 (+)MPROMDB
RGD ID:6830121
Promoter ID:MM_KWN:26967
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   Liver
Transcripts:OTTMUST00000050147
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361937,511,126 - 37,511,702 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:96086 AgrOrtholog
Ensembl Genes ENSMUSG00000024986 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000025944 ENTREZGENE
  ENSMUST00000025944.9 UniProtKB/Swiss-Prot
  ENSMUST00000128184.3 UniProtKB/TrEMBL
Gene3D-CATH Homeodomain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Homeobox-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox_CS UniProtKB/Swiss-Prot
  Homeobox_DNA-bind_prot UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox_metazoa UniProtKB/Swiss-Prot
KEGG Report mmu:15242 UniProtKB/Swiss-Prot
MGD MGI:96086 ENTREZGENE
NCBI Gene 15242 ENTREZGENE
PANTHER HEMATOPOIETICALLY-EXPRESSED HOMEOBOX PROTEIN HHEX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HOMEOBOX PROTEIN HHEX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Homeodomain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB HHEX RGD
PhenoGen Hhex PhenoGen
PRINTS HOMEOBOX UniProtKB/Swiss-Prot
PROSITE HOMEOBOX_1 UniProtKB/Swiss-Prot
  HOMEOBOX_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART HOX UniProtKB/Swiss-Prot
Superfamily-SCOP SSF46689 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt G3UXH1_MOUSE UniProtKB/TrEMBL
  HHEX_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q544N6 ENTREZGENE
  Q9CRV1 ENTREZGENE
  Q9R1X2 ENTREZGENE
UniProt Secondary Q544N6 UniProtKB/Swiss-Prot
  Q9CRV1 UniProtKB/Swiss-Prot
  Q9R1X2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-05 Hhex  hematopoietically expressed homeobox  Hhex-rs2  hematopoietically expressed homeobox, related sequence 2  Data merged from RGD:1609344 737654 PROVISIONAL