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Gene: Hhex (hematopoietically expressed homeobox) Mus musculus
Symbol: Hhex
Name: hematopoietically expressed homeobox
Description: Exhibits several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; HMG box domain binding activity; and RNA polymerase II regulatory region sequence-specific DNA binding activity. Involved in several processes, including animal organ development; growth; and regulation of signal transduction. Localizes to the cytoplasm and nucleus. Is expressed in several structures, including central nervous system; early conceptus; gut; liver and biliary system; and metanephros. Orthologous to human HHEX (hematopoietically expressed homeobox); PARTICIPATES IN maturity-onset diabetes of the young pathway; INTERACTS WITH 1,2-dichloroethane; 2,3',4,4',5-Pentachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: hematopoietically expressed homeobox, related sequence 2; hematopoietically-expressed homeobox protein Hhex; Hex; Hex1; Hhex-rs2; homeobox protein HEX; homeobox protein PRH; mHex; Prh; Prhx
Homo sapiens (human) : HHEX (hematopoietically expressed homeobox)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Hhex (hematopoietically expressed homeobox)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hhex (hematopoietically expressed homeobox)
Pan paniscus (bonobo/pygmy chimpanzee) : HHEX (hematopoietically expressed homeobox)
Canis lupus familiaris (dog) : HHEX (hematopoietically expressed homeobox)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hhex (hematopoietically expressed homeobox)
Sus scrofa (pig) : HHEX (hematopoietically expressed homeobox)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1937,434,810 - 37,440,731 (+)Ensembl
GRCm381937,434,841 - 37,440,731 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371937,509,331 - 37,515,221 (+)NCBIGRCm37mm9NCBIm37
MGSCv361937,499,985 - 37,505,875 (+)NCBImm8
Celera1938,221,629 - 38,227,525 (+)NCBICelera
Cytogenetic Map19 C2NCBI
cM Map1932.28NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Hhex
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 731855
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.