Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Acot8 | Mouse | 1,2-dimethylhydrazine | multiple interactions | EXP | | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of ACOT8 mRNA | CTD | PMID:22206623 | Acot8 | Mouse | 17alpha-ethynylestradiol | increases expression | ISO | Acot8 (Rattus norvegicus) | 6480464 | Ethinyl Estradiol results in increased expression of ACOT8 mRNA | CTD | PMID:17108234 | Acot8 | Mouse | 17beta-estradiol | increases expression | ISO | Acot8 (Rattus norvegicus) | 6480464 | Estradiol results in increased expression of ACOT8 mRNA | CTD | PMID:32145629 | Acot8 | Mouse | 2,2',4,4',5,5'-hexachlorobiphenyl | multiple interactions | EXP | | 6480464 | [Tetrachlorodibenzodioxin co-treated with 2 more ... | CTD | PMID:28433925 | Acot8 | Mouse | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of ACOT8 mRNA | CTD | PMID:17942748 | Acot8 | Mouse | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Acot8 (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of ACOT8 mRNA | CTD | PMID:33387578 | Acot8 | Mouse | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | EXP | | 6480464 | [Tetrachlorodibenzodioxin co-treated with 2 more ... | CTD | PMID:28433925 | Acot8 | Mouse | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of ACOT8 mRNA | CTD | PMID:20702594 and PMID:21570461 | Acot8 | Mouse | 2,3,7,8-Tetrachlorodibenzofuran | affects expression | EXP | | 6480464 | 2 more ... | CTD | PMID:20702594 | Acot8 | Mouse | 2-hydroxypropanoic acid | decreases expression | ISO | ACOT8 (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of ACOT8 mRNA | CTD | PMID:30851411 | Acot8 | Mouse | 2-palmitoylglycerol | increases expression | ISO | ACOT8 (Homo sapiens) | 6480464 | 2-palmitoylglycerol results in increased expression of ACOT8 mRNA | CTD | PMID:37199045 | Acot8 | Mouse | 3,4-methylenedioxymethamphetamine | increases expression | EXP | | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in increased expression of ACOT8 mRNA | CTD | PMID:20188158 | Acot8 | Mouse | 4,4'-sulfonyldiphenol | decreases methylation | ISO | ACOT8 (Homo sapiens) | 6480464 | bisphenol S results in decreased methylation of ACOT8 gene | CTD | PMID:31601247 | Acot8 | Mouse | 6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime | multiple interactions | ISO | ACOT8 (Homo sapiens) | 6480464 | [6-(4-chlorophenyl)imidazo(2 more ... | CTD | PMID:30611723 | Acot8 | Mouse | amiodarone | increases expression | ISO | ACOT8 (Homo sapiens) | 6480464 | Amiodarone results in increased expression of ACOT8 mRNA | CTD | PMID:19774075 | Acot8 | Mouse | ammonium chloride | affects expression | ISO | Acot8 (Rattus norvegicus) | 6480464 | Ammonium Chloride affects the expression of ACOT8 mRNA | CTD | PMID:16483693 | Acot8 | Mouse | antirheumatic drug | decreases expression | ISO | ACOT8 (Homo sapiens) | 6480464 | Antirheumatic Agents results in decreased expression of ACOT8 mRNA | CTD | PMID:24449571 | Acot8 | Mouse | Aroclor 1254 | increases expression | EXP | | 6480464 | Chlorodiphenyl (54% Chlorine) results in increased expression of ACOT8 mRNA | CTD | PMID:23650126 | Acot8 | Mouse | atrazine | decreases expression | ISO | ACOT8 (Homo sapiens) | 6480464 | Atrazine results in decreased expression of ACOT8 mRNA | CTD | PMID:22378314 | Acot8 | Mouse | benzo[a]pyrene | increases methylation | ISO | ACOT8 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of ACOT8 promoter | CTD | PMID:27901495 | Acot8 | Mouse | bis(2-ethylhexyl) phthalate | increases expression | EXP | | 6480464 | Diethylhexyl Phthalate results in increased expression of ACOT8 mRNA | CTD | PMID:19850644 | Acot8 | Mouse | bis(2-ethylhexyl) phthalate | multiple interactions | EXP | | 6480464 | [Tetrachlorodibenzodioxin co-treated with 2 more ... | CTD | PMID:19850644 and PMID:28433925 | Acot8 | Mouse | bisphenol A | increases expression | ISO | Acot8 (Rattus norvegicus) | 6480464 | bisphenol A results in increased expression of ACOT8 mRNA | CTD | PMID:25181051 | Acot8 | Mouse | bisphenol A | affects expression | ISO | Acot8 (Rattus norvegicus) | 6480464 | bisphenol A affects the expression of ACOT8 mRNA | CTD | PMID:32145629 | Acot8 | Mouse | bisphenol A | multiple interactions | EXP | | 6480464 | [Tetrachlorodibenzodioxin co-treated with 2 more ... | CTD | PMID:28433925 | Acot8 | Mouse | cadmium atom | decreases expression | EXP | | 6480464 | Cadmium results in decreased expression of ACOT8 mRNA | CTD | PMID:24067728 | Acot8 | Mouse | cadmium dichloride | decreases expression | ISO | ACOT8 (Homo sapiens) | 6480464 | Cadmium Chloride results in decreased expression of ACOT8 mRNA | CTD | PMID:21457566 and PMID:38568856 | Acot8 | Mouse | CGP 52608 | multiple interactions | ISO | ACOT8 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to ACOT8 gene] | CTD | PMID:28238834 | Acot8 | Mouse | clofibrate | increases expression | EXP | | 6480464 | Clofibrate results in increased expression of ACOT8 mRNA | CTD | PMID:23811191 | Acot8 | Mouse | coenzyme A | affects hydrolysis | EXP | | 6480464 | ACOT8 protein affects the hydrolysis of Coenzyme A analog | CTD | PMID:16141203 | Acot8 | Mouse | copper(II) sulfate | increases expression | ISO | ACOT8 (Homo sapiens) | 6480464 | Copper Sulfate results in increased expression of ACOT8 mRNA | CTD | PMID:19549813 | Acot8 | Mouse | crocidolite asbestos | decreases expression | EXP | | 6480464 | Asbestos and Crocidolite results in decreased expression of ACOT8 mRNA | CTD | PMID:29279043 | Acot8 | Mouse | dichloroacetic acid | increases expression | EXP | | 6480464 | Dichloroacetic Acid results in increased expression of ACOT8 mRNA | CTD | PMID:28962523 | Acot8 | Mouse | diquat | increases expression | EXP | | 6480464 | Diquat results in increased expression of ACOT8 mRNA | CTD | PMID:36851058 | Acot8 | Mouse | diuron | decreases expression | ISO | ACOT8 (Homo sapiens) | 6480464 | Diuron results in decreased expression of ACOT8 mRNA | CTD | PMID:35967413 | Acot8 | Mouse | doxorubicin | decreases expression | ISO | ACOT8 (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of ACOT8 mRNA | CTD | PMID:29803840 | Acot8 | Mouse | finasteride | increases expression | ISO | Acot8 (Rattus norvegicus) | 6480464 | Finasteride results in increased expression of ACOT8 mRNA | CTD | PMID:24136188 | Acot8 | Mouse | flutamide | increases expression | ISO | Acot8 (Rattus norvegicus) | 6480464 | Flutamide results in increased expression of ACOT8 mRNA | CTD | PMID:24136188 | Acot8 | Mouse | folic acid | multiple interactions | EXP | | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of ACOT8 mRNA | CTD | PMID:22206623 | Acot8 | Mouse | gentamycin | increases expression | ISO | Acot8 (Rattus norvegicus) | 6480464 | Gentamicins results in increased expression of ACOT8 mRNA | CTD | PMID:33387578 | Acot8 | Mouse | glutaryl-CoA | affects hydrolysis | EXP | | 6480464 | ACOT8 protein affects the hydrolysis of glutaryl-coenzyme A | CTD | PMID:16141203 | Acot8 | Mouse | GW 4064 | multiple interactions | ISO | ACOT8 (Homo sapiens) | 6480464 | [GW 4064 co-treated with Oleic Acid] results in decreased expression of ACOT8 mRNA | CTD | PMID:30611723 | Acot8 | Mouse | indole-3-methanol | affects expression | ISO | Acot8 (Rattus norvegicus) | 6480464 | indole-3-carbinol affects the expression of ACOT8 mRNA | CTD | PMID:21396975 | Acot8 | Mouse | indometacin | decreases expression | ISO | Acot8 (Rattus norvegicus) | 6480464 | Indomethacin results in decreased expression of ACOT8 mRNA | CTD | PMID:36868495 | Acot8 | Mouse | ketoconazole | increases expression | ISO | Acot8 (Rattus norvegicus) | 6480464 | Ketoconazole results in increased expression of ACOT8 mRNA | CTD | PMID:37077353 | Acot8 | Mouse | methyl methanesulfonate | increases expression | ISO | ACOT8 (Homo sapiens) | 6480464 | Methyl Methanesulfonate results in increased expression of ACOT8 mRNA | CTD | PMID:23649840 | Acot8 | Mouse | nefazodone | increases expression | ISO | Acot8 (Rattus norvegicus) | 6480464 | nefazodone results in increased expression of ACOT8 mRNA | CTD | PMID:24136188 | Acot8 | Mouse | oleic acid | multiple interactions | ISO | ACOT8 (Homo sapiens) | 6480464 | [6-(4-chlorophenyl)imidazo(2 more ... | CTD | PMID:30611723 | Acot8 | Mouse | orlistat | decreases expression | ISO | ACOT8 (Homo sapiens) | 6480464 | Orlistat results in decreased expression of ACOT8 protein | CTD | PMID:30667213 | Acot8 | Mouse | ozone | multiple interactions | ISO | ACOT8 (Homo sapiens) | 6480464 | [Air Pollutants results in increased abundance of Ozone] which affects the expression of ACOT8 mRNA | CTD | PMID:35430440 | Acot8 | Mouse | paclitaxel | decreases expression | ISO | ACOT8 (Homo sapiens) | 6480464 | Paclitaxel results in decreased expression of ACOT8 protein | CTD | PMID:30667213 | Acot8 | Mouse | paracetamol | increases expression | ISO | Acot8 (Rattus norvegicus) | 6480464 | Acetaminophen results in increased expression of ACOT8 mRNA | CTD | PMID:33387578 | Acot8 | Mouse | perfluorooctanoic acid | increases expression | ISO | Acot8 (Rattus norvegicus) | 6480464 | perfluorooctanoic acid results in increased expression of ACOT8 mRNA and perfluorooctanoic acid results in increased expression of ACOT8 protein | CTD | PMID:16221955 and PMID:34958885 | Acot8 | Mouse | perfluorooctanoic acid | increases expression | EXP | | 6480464 | perfluorooctanoic acid results in increased expression of ACOT8 mRNA | CTD | PMID:17681415 and PMID:23626681 | Acot8 | Mouse | perfluorooctanoic acid | multiple interactions | EXP | | 6480464 | Dietary Fats and Unsaturated promotes the reaction [perfluorooctanoic acid results in increased expression of ACOT8 mRNA] | CTD | PMID:23626681 | Acot8 | Mouse | pirinixic acid | multiple interactions | EXP | | 6480464 | PPARA protein promotes the reaction [pirinixic acid results in increased expression of ACOT8 mRNA] | CTD | PMID:17950772 | Acot8 | Mouse | pirinixic acid | increases expression | EXP | | 6480464 | pirinixic acid results in increased expression of ACOT8 mRNA | CTD | PMID:16357043 more ... | Acot8 | Mouse | pirinixic acid | increases expression | ISO | Acot8 (Rattus norvegicus) | 6480464 | pirinixic acid results in increased expression of ACOT8 mRNA | CTD | PMID:22484513 | Acot8 | Mouse | rac-lactic acid | decreases expression | ISO | ACOT8 (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of ACOT8 mRNA | CTD | PMID:30851411 | Acot8 | Mouse | resveratrol | multiple interactions | ISO | ACOT8 (Homo sapiens) | 6480464 | [Plant Extracts co-treated with Resveratrol] results in increased expression of ACOT8 mRNA | CTD | PMID:23557933 | Acot8 | Mouse | Tesaglitazar | increases expression | ISO | Acot8 (Rattus norvegicus) | 6480464 | tesaglitazar results in increased expression of ACOT8 mRNA | CTD | PMID:21515302 | Acot8 | Mouse | tetrachloromethane | increases expression | EXP | | 6480464 | Carbon Tetrachloride results in increased expression of ACOT8 mRNA | CTD | PMID:31919559 | Acot8 | Mouse | thioacetamide | increases expression | ISO | Acot8 (Rattus norvegicus) | 6480464 | Thioacetamide results in increased expression of ACOT8 mRNA | CTD | PMID:26222700 | Acot8 | Mouse | triphenyl phosphate | affects expression | ISO | ACOT8 (Homo sapiens) | 6480464 | triphenyl phosphate affects the expression of ACOT8 mRNA | CTD | PMID:37042841 | Acot8 | Mouse | triptonide | increases expression | EXP | | 6480464 | triptonide results in increased expression of ACOT8 mRNA | CTD | PMID:33045310 | Acot8 | Mouse | tungsten | increases expression | EXP | | 6480464 | Tungsten results in increased expression of ACOT8 mRNA | CTD | PMID:30912803 | Acot8 | Mouse | valproic acid | affects expression | EXP | | 6480464 | Valproic Acid affects the expression of ACOT8 mRNA | CTD | PMID:17292431 and PMID:17963808 | |