ACOT8 (acyl-CoA thioesterase 8) - Rat Genome Database

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Gene: ACOT8 (acyl-CoA thioesterase 8) Sus scrofa
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Symbol: ACOT8
Name: acyl-CoA thioesterase 8
RGD ID: 13854624
Description: ENCODES a protein that exhibits choloyl-CoA hydrolase activity (ortholog); long-chain fatty acyl-CoA hydrolase activity (ortholog); INVOLVED IN acyl-CoA metabolic process (ortholog); ASSOCIATED WITH adenosine deaminase deficiency (ortholog); focal epilepsy (ortholog); T-Cell Immunodeficiency, Recurrent Infections, and Autoimmunity with or without Cardiac Malformations (ortholog); FOUND IN peroxisomal matrix (inferred); peroxisome (inferred); INTERACTS WITH deoxynivalenol
Type: protein-coding
RefSeq Status: MODEL
Previously known as: acyl-coenzyme A thioesterase 8
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1748,039,628 - 48,054,335 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11748,039,627 - 48,054,335 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21753,685,696 - 53,700,414 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
peroxisomal matrix  (IBA,IEA)
peroxisome  (IEA)

References
Additional References at PubMed
PMID:14681463   PMID:17145712   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
ACOT8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1748,039,628 - 48,054,335 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11748,039,627 - 48,054,335 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21753,685,696 - 53,700,414 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ACOT8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382045,841,721 - 45,857,392 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2045,841,721 - 45,857,405 (-)EnsemblGRCh38hg38GRCh38
GRCh372044,470,360 - 44,486,031 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362043,903,768 - 43,919,442 (-)NCBINCBI36Build 36hg18NCBI36
Build 342043,903,767 - 43,919,442NCBI
Celera2041,180,856 - 41,196,530 (-)NCBICelera
Cytogenetic Map20q13.12NCBI
HuRef2041,212,129 - 41,227,770 (-)NCBIHuRef
CHM1_12044,373,492 - 44,389,180 (-)NCBICHM1_1
T2T-CHM13v2.02047,578,222 - 47,593,911 (-)NCBIT2T-CHM13v2.0
Acot8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392164,634,688 - 164,662,132 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2164,634,685 - 164,646,802 (-)EnsemblGRCm39 Ensembl
GRCm382164,792,768 - 164,820,219 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2164,792,765 - 164,804,882 (-)EnsemblGRCm38mm10GRCm38
MGSCv372164,618,268 - 164,630,381 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362164,483,973 - 164,496,077 (-)NCBIMGSCv36mm8
Celera2170,730,175 - 170,742,288 (-)NCBICelera
Cytogenetic Map2H3NCBI
cM Map285.27NCBI
Acot8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83173,950,530 - 173,962,188 (-)NCBIGRCr8
mRatBN7.23153,531,192 - 153,542,851 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3153,531,193 - 153,542,851 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3157,339,669 - 157,351,337 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03165,838,639 - 165,850,307 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03163,582,412 - 163,594,081 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03161,260,837 - 161,272,495 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3161,259,735 - 161,272,460 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03167,446,048 - 167,457,779 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43155,828,209 - 155,839,862 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13155,734,245 - 155,745,898 (-)NCBI
Celera3152,138,819 - 152,150,462 (-)NCBICelera
Cytogenetic Map3q42NCBI
Acot8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544511,434,082 - 11,454,806 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544511,434,649 - 11,454,806 (+)NCBIChiLan1.0ChiLan1.0
ACOT8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22151,583,277 - 51,599,011 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12051,576,385 - 51,592,109 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02042,180,734 - 42,196,466 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12043,268,264 - 43,283,989 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2043,268,264 - 43,283,989 (-)Ensemblpanpan1.1panPan2
ACOT8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12433,149,415 - 33,163,086 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2433,128,290 - 33,163,050 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2432,676,438 - 32,690,112 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02433,859,698 - 33,873,388 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2433,859,700 - 33,873,380 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12433,118,251 - 33,131,923 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02433,233,332 - 33,246,997 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02433,772,459 - 33,786,134 (-)NCBIUU_Cfam_GSD_1.0
Acot8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640191,713,172 - 191,726,893 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365147,166,818 - 7,180,537 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365147,166,392 - 7,180,537 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACOT8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1218,026,927 - 18,043,940 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl218,027,016 - 18,043,823 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605066,666,666 - 66,683,894 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in ACOT8
551 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
10 4 23 3 2 5 14 12 23 3 6 3

Sequence


Ensembl Acc Id: ENSSSCT00000025270   ⟹   ENSSSCP00000020956
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1748,039,628 - 48,054,335 (-)Ensembl
RefSeq Acc Id: XM_001928889   ⟹   XP_001928924
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11748,039,627 - 48,054,335 (-)NCBI
Sequence:
RefSeq Acc Id: XP_001928924   ⟸   XM_001928889
- UniProtKB: I3LA89 (UniProtKB/TrEMBL),   A0A4X1U116 (UniProtKB/TrEMBL),   A0A8D1V6H0 (UniProtKB/TrEMBL),   A0A8D1QJC4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000020956   ⟸   ENSSSCT00000025270

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000007426 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005020576 UniProtKB/TrEMBL
  ENSSSCG00015055059 UniProtKB/TrEMBL
  ENSSSCG00025065425 UniProtKB/TrEMBL
  ENSSSCG00030057313 UniProtKB/TrEMBL
  ENSSSCG00035074812 UniProtKB/TrEMBL
  ENSSSCG00040024953 UniProtKB/TrEMBL
  ENSSSCG00045003709 UniProtKB/TrEMBL
  ENSSSCG00050070704 UniProtKB/TrEMBL
  ENSSSCG00055013902 UniProtKB/TrEMBL
  ENSSSCG00060033558 UniProtKB/TrEMBL
  ENSSSCG00065001455 UniProtKB/TrEMBL
  ENSSSCG00070013273 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000025270 ENTREZGENE
  ENSSSCT00000025270.3 UniProtKB/TrEMBL
  ENSSSCT00005032424.1 UniProtKB/TrEMBL
  ENSSSCT00015073366.1 UniProtKB/TrEMBL
  ENSSSCT00025089781.1 UniProtKB/TrEMBL
  ENSSSCT00025089852.1 UniProtKB/TrEMBL
  ENSSSCT00030079911.1 UniProtKB/TrEMBL
  ENSSSCT00035101659.1 UniProtKB/TrEMBL
  ENSSSCT00035101672.1 UniProtKB/TrEMBL
  ENSSSCT00040033406.1 UniProtKB/TrEMBL
  ENSSSCT00045006129.1 UniProtKB/TrEMBL
  ENSSSCT00045006136.1 UniProtKB/TrEMBL
  ENSSSCT00050096414.1 UniProtKB/TrEMBL
  ENSSSCT00055027424.1 UniProtKB/TrEMBL
  ENSSSCT00055027461.1 UniProtKB/TrEMBL
  ENSSSCT00060045505.1 UniProtKB/TrEMBL
  ENSSSCT00065001799.1 UniProtKB/TrEMBL
  ENSSSCT00065001810.1 UniProtKB/TrEMBL
  ENSSSCT00070025881.1 UniProtKB/TrEMBL
  ENSSSCT00070025884.1 UniProtKB/TrEMBL
Gene3D-CATH 2.40.160.210 UniProtKB/TrEMBL
  Hotdog Thioesterase UniProtKB/TrEMBL
InterPro ACOT8-like_C UniProtKB/TrEMBL
  Acyl-CoA_hotdog UniProtKB/TrEMBL
  Acyl_CoA_thio UniProtKB/TrEMBL
  HotDog_dom_sf UniProtKB/TrEMBL
  TesB_ACOT8-like_N UniProtKB/TrEMBL
KEGG Report ssc:100157173 UniProtKB/TrEMBL
NCBI Gene ACOT8 ENTREZGENE
PANTHER ACYL-COENZYME A THIOESTERASE 8 UniProtKB/TrEMBL
  PTHR11066 UniProtKB/TrEMBL
Pfam 4HBT_3 UniProtKB/TrEMBL
  4HBT_3C UniProtKB/TrEMBL
Superfamily-SCOP SSF54637 UniProtKB/TrEMBL
UniProt A0A4X1U0S2_PIG UniProtKB/TrEMBL
  A0A4X1U116 ENTREZGENE
  A0A8D1QJC4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1V6H0 ENTREZGENE, UniProtKB/TrEMBL
  I3LA89 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A0A4X1U116 UniProtKB/TrEMBL
VGNC ID VGNC:95707 ENTREZGENE