Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Hif3a | Mouse | 1,10-phenanthroline | decreases expression | ISO | HIF3A (Homo sapiens) | 6480464 | 1 and 10-phenanthroline results in decreased expression of HIF3A mRNA | CTD | PMID:19502547 | Hif3a | Mouse | 17beta-estradiol | multiple interactions | ISO | Hif3a (Rattus norvegicus) | 6480464 | [bisphenol A co-treated with Estradiol] results in increased expression of HIF3A mRNA | CTD | PMID:26496021 | Hif3a | Mouse | 17beta-estradiol | multiple interactions | ISO | HIF3A (Homo sapiens) | 6480464 | [Estradiol co-treated with TGFB1 protein] results in decreased expression of HIF3A mRNA | CTD | PMID:30165855 | Hif3a | Mouse | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of HIF3A mRNA | CTD | PMID:21570461 and PMID:24058054 | Hif3a | Mouse | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of HIF3A mRNA | CTD | PMID:19770486 | Hif3a | Mouse | 2-palmitoylglycerol | increases expression | ISO | HIF3A (Homo sapiens) | 6480464 | 2-palmitoylglycerol results in increased expression of HIF3A mRNA | CTD | PMID:37199045 | Hif3a | Mouse | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | HIF3A (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of HIF3A mRNA | CTD | PMID:28628672 | Hif3a | Mouse | 4-hydroxyphenyl retinamide | decreases expression | EXP | | 6480464 | Fenretinide results in decreased expression of HIF3A mRNA | CTD | PMID:28973697 | Hif3a | Mouse | 4-nitrophenol | decreases expression | EXP | | 6480464 | 4-nitrophenol results in decreased expression of HIF3A mRNA | CTD | PMID:34673133 | Hif3a | Mouse | 5-chloro-7-iodoquinolin-8-ol | decreases expression | ISO | HIF3A (Homo sapiens) | 6480464 | Clioquinol results in decreased expression of HIF3A mRNA | CTD | PMID:19502547 | Hif3a | Mouse | 6-propyl-2-thiouracil | decreases expression | ISO | Hif3a (Rattus norvegicus) | 6480464 | Propylthiouracil results in decreased expression of HIF3A mRNA | CTD | PMID:24780913 | Hif3a | Mouse | acrylamide | decreases expression | ISO | HIF3A (Homo sapiens) | 6480464 | Acrylamide results in decreased expression of HIF3A mRNA | CTD | PMID:32763439 | Hif3a | Mouse | aflatoxin B1 | increases methylation | ISO | HIF3A (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased methylation of HIF3A promoter | CTD | PMID:30157460 | Hif3a | Mouse | allethrin | multiple interactions | ISO | Hif3a (Rattus norvegicus) | 6480464 | [cypermethrin co-treated with decamethrin co-treated with fenvalerate co-treated with cyhalothrin co-treated with Allethrins] results in decreased expression of HIF3A protein | CTD | PMID:34896426 | Hif3a | Mouse | ammonium chloride | affects expression | ISO | Hif3a (Rattus norvegicus) | 6480464 | Ammonium Chloride affects the expression of HIF3A mRNA | CTD | PMID:16483693 | Hif3a | Mouse | benzo[a]pyrene | decreases expression | ISO | HIF3A (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of HIF3A mRNA | CTD | PMID:21871943 | Hif3a | Mouse | benzo[a]pyrene | increases methylation | ISO | HIF3A (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of HIF3A 5' UTR | CTD | PMID:27901495 | Hif3a | Mouse | benzo[a]pyrene | affects methylation | ISO | HIF3A (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of HIF3A 3' UTR and Benzo(a)pyrene affects the methylation of HIF3A promoter | CTD | PMID:27901495 | Hif3a | Mouse | benzo[a]pyrene | increases expression | EXP | | 6480464 | Benzo(a)pyrene results in increased expression of HIF3A mRNA | CTD | PMID:22228805 and PMID:27195522 | Hif3a | Mouse | bis(2-ethylhexyl) phthalate | decreases expression | ISO | HIF3A (Homo sapiens) | 6480464 | Diethylhexyl Phthalate results in decreased expression of HIF3A mRNA | CTD | PMID:31163220 | Hif3a | Mouse | bisphenol A | multiple interactions | ISO | Hif3a (Rattus norvegicus) | 6480464 | [bisphenol A co-treated with Estradiol] results in increased expression of HIF3A mRNA | CTD | PMID:26496021 | Hif3a | Mouse | bisphenol A | multiple interactions | ISO | HIF3A (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of HIF3A mRNA | CTD | PMID:28628672 | Hif3a | Mouse | bisphenol A | affects methylation | EXP | | 6480464 | bisphenol A affects the methylation of HIF3A promoter | CTD | PMID:27334623 | Hif3a | Mouse | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of HIF3A mRNA | CTD | PMID:25594700 | Hif3a | Mouse | bisphenol A | decreases expression | ISO | Hif3a (Rattus norvegicus) | 6480464 | bisphenol A results in decreased expression of HIF3A mRNA | CTD | PMID:25181051 | Hif3a | Mouse | bisphenol F | decreases expression | EXP | | 6480464 | bisphenol F results in decreased expression of HIF3A mRNA | CTD | PMID:38685157 | Hif3a | Mouse | bromobenzene | increases expression | ISO | Hif3a (Rattus norvegicus) | 6480464 | bromobenzene results in increased expression of HIF3A mRNA | CTD | PMID:32479839 | Hif3a | Mouse | buta-1,3-diene | increases expression | EXP | | 6480464 | 1 and 3-butadiene results in increased expression of HIF3A mRNA | CTD | PMID:29038090 | Hif3a | Mouse | C60 fullerene | decreases expression | ISO | Hif3a (Rattus norvegicus) | 6480464 | fullerene C60 results in decreased expression of HIF3A mRNA | CTD | PMID:19167457 | Hif3a | Mouse | carbon nanotube | affects expression | EXP | | 6480464 | Nanotubes more ... | CTD | PMID:25554681 | Hif3a | Mouse | chloroprene | increases expression | EXP | | 6480464 | Chloroprene results in increased expression of HIF3A mRNA | CTD | PMID:23125180 | Hif3a | Mouse | chlorpyrifos | increases expression | EXP | | 6480464 | Chlorpyrifos results in increased expression of HIF3A mRNA | CTD | PMID:32715474 and PMID:37019170 | Hif3a | Mouse | choline | multiple interactions | EXP | | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of HIF3A gene | CTD | PMID:20938992 | Hif3a | Mouse | clofibrate | decreases expression | EXP | | 6480464 | Clofibrate results in decreased expression of HIF3A mRNA | CTD | PMID:17585979 | Hif3a | Mouse | cobalt dichloride | increases expression | ISO | HIF3A (Homo sapiens) | 6480464 | cobaltous chloride results in increased expression of HIF3A mRNA and cobaltous chloride results in increased expression of HIF3A protein | CTD | PMID:16775626 | Hif3a | Mouse | cobalt dichloride | increases expression | ISO | Hif3a (Rattus norvegicus) | 6480464 | cobaltous chloride results in increased expression of HIF3A protein | CTD | PMID:21546903 | Hif3a | Mouse | cobalt dichloride | decreases expression | ISO | HIF3A (Homo sapiens) | 6480464 | cobaltous chloride results in decreased expression of HIF3A mRNA | CTD | PMID:19502547 | Hif3a | Mouse | cobalt(2+) sulfate | decreases expression | ISO | HIF3A (Homo sapiens) | 6480464 | cobalt sulfate results in decreased expression of HIF3A mRNA | CTD | PMID:19502547 | Hif3a | Mouse | copper atom | increases expression | ISO | Hif3a (Rattus norvegicus) | 6480464 | Copper deficiency results in increased expression of HIF3A mRNA | CTD | PMID:26033743 | Hif3a | Mouse | copper(0) | increases expression | ISO | Hif3a (Rattus norvegicus) | 6480464 | Copper deficiency results in increased expression of HIF3A mRNA | CTD | PMID:26033743 | Hif3a | Mouse | cyhalothrin | multiple interactions | ISO | Hif3a (Rattus norvegicus) | 6480464 | [cypermethrin co-treated with decamethrin co-treated with fenvalerate co-treated with cyhalothrin co-treated with Allethrins] results in decreased expression of HIF3A protein | CTD | PMID:34896426 | Hif3a | Mouse | cypermethrin | multiple interactions | ISO | Hif3a (Rattus norvegicus) | 6480464 | [cypermethrin co-treated with decamethrin co-treated with fenvalerate co-treated with cyhalothrin co-treated with Allethrins] results in decreased expression of HIF3A protein | CTD | PMID:34896426 | Hif3a | Mouse | delphinidin | multiple interactions | ISO | HIF3A (Homo sapiens) | 6480464 | delphinidin inhibits the reaction [Hydrogen Peroxide results in increased expression of HIF3A protein] | CTD | PMID:18603805 | Hif3a | Mouse | desferrioxamine B | increases expression | ISO | HIF3A (Homo sapiens) | 6480464 | Deferoxamine results in increased expression of HIF3A protein | CTD | PMID:16775626 | Hif3a | Mouse | dexamethasone | multiple interactions | ISO | HIF3A (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of HIF3A mRNA | CTD | PMID:28628672 | Hif3a | Mouse | dichloroacetic acid | decreases expression | EXP | | 6480464 | Dichloroacetic Acid results in decreased expression of HIF3A mRNA | CTD | PMID:28962523 | Hif3a | Mouse | dicrotophos | increases expression | ISO | HIF3A (Homo sapiens) | 6480464 | dicrotophos results in increased expression of HIF3A mRNA | CTD | PMID:28302478 | Hif3a | Mouse | dinophysistoxin 1 | affects expression | ISO | HIF3A (Homo sapiens) | 6480464 | dinophysistoxin 1 affects the expression of HIF3A mRNA | CTD | PMID:28939011 | Hif3a | Mouse | dioxygen | increases expression | ISO | HIF3A (Homo sapiens) | 6480464 | Oxygen deficiency results in increased expression of HIF3A mRNA | CTD | PMID:26516004 and PMID:34826399 | Hif3a | Mouse | dioxygen | multiple interactions | ISO | HIF3A (Homo sapiens) | 6480464 | Oxygen deficiency promotes the reaction [HIF3A protein binds to KDM3A promoter] | CTD | PMID:34826399 | Hif3a | Mouse | diquat | increases expression | EXP | | 6480464 | Diquat results in increased expression of HIF3A mRNA | CTD | PMID:36851058 | Hif3a | Mouse | dorsomorphin | multiple interactions | ISO | HIF3A (Homo sapiens) | 6480464 | [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | Hif3a | Mouse | doxorubicin | decreases expression | ISO | HIF3A (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of HIF3A mRNA | CTD | PMID:29803840 and PMID:30031762 | Hif3a | Mouse | ethanol | increases expression | EXP | | 6480464 | Ethanol results in increased expression of HIF3A mRNA | CTD | PMID:29018328 | Hif3a | Mouse | ethanol | affects expression | EXP | | 6480464 | Ethanol affects the expression of HIF3A mRNA | CTD | PMID:30319688 | Hif3a | Mouse | fenvalerate | multiple interactions | ISO | Hif3a (Rattus norvegicus) | 6480464 | [cypermethrin co-treated with decamethrin co-treated with fenvalerate co-treated with cyhalothrin co-treated with Allethrins] results in decreased expression of HIF3A protein | CTD | PMID:34896426 | Hif3a | Mouse | folic acid | multiple interactions | EXP | | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of HIF3A gene | CTD | PMID:20938992 | Hif3a | Mouse | folic acid | decreases expression | EXP | | 6480464 | Folic Acid results in decreased expression of HIF3A mRNA | CTD | PMID:25629700 | Hif3a | Mouse | graphite | affects expression | ISO | Hif3a (Rattus norvegicus) | 6480464 | Graphite affects the expression of HIF3A mRNA | CTD | PMID:29933104 | Hif3a | Mouse | GW 4064 | decreases expression | EXP | | 6480464 | GW 4064 results in decreased expression of HIF3A mRNA | CTD | PMID:26655953 | Hif3a | Mouse | hydrogen peroxide | multiple interactions | ISO | HIF3A (Homo sapiens) | 6480464 | delphinidin inhibits the reaction [Hydrogen Peroxide results in increased expression of HIF3A protein] | CTD | PMID:18603805 | Hif3a | Mouse | hydrogen peroxide | increases expression | ISO | HIF3A (Homo sapiens) | 6480464 | Hydrogen Peroxide results in increased expression of HIF3A protein | CTD | PMID:18603805 | Hif3a | Mouse | indometacin | multiple interactions | ISO | HIF3A (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of HIF3A mRNA | CTD | PMID:28628672 | Hif3a | Mouse | isoprenaline | increases expression | ISO | HIF3A (Homo sapiens) | 6480464 | Isoproterenol results in increased expression of HIF3A mRNA | CTD | PMID:24286936 | Hif3a | Mouse | isoprenaline | increases expression | ISO | Hif3a (Rattus norvegicus) | 6480464 | Isoproterenol results in increased expression of HIF3A mRNA | CTD | PMID:24286936 | Hif3a | Mouse | L-methionine | multiple interactions | EXP | | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of HIF3A gene | CTD | PMID:20938992 | Hif3a | Mouse | lead diacetate | decreases expression | EXP | | 6480464 | lead acetate results in decreased expression of HIF3A mRNA | CTD | PMID:21829687 | Hif3a | Mouse | lead diacetate | increases expression | ISO | Hif3a (Rattus norvegicus) | 6480464 | lead acetate results in increased expression of HIF3A mRNA | CTD | PMID:22641619 | Hif3a | Mouse | menadione | affects expression | ISO | HIF3A (Homo sapiens) | 6480464 | Vitamin K 3 affects the expression of HIF3A mRNA | CTD | PMID:20044591 | Hif3a | Mouse | mercury atom | decreases expression | ISO | HIF3A (Homo sapiens) | 6480464 | Mercury results in decreased expression of HIF3A mRNA | CTD | PMID:19937285 | Hif3a | Mouse | mercury dibromide | multiple interactions | ISO | HIF3A (Homo sapiens) | 6480464 | [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HIF3A mRNA | CTD | PMID:27188386 | Hif3a | Mouse | mercury(0) | decreases expression | ISO | HIF3A (Homo sapiens) | 6480464 | Mercury results in decreased expression of HIF3A mRNA | CTD | PMID:19937285 | Hif3a | Mouse | methotrexate | decreases expression | ISO | HIF3A (Homo sapiens) | 6480464 | Methotrexate results in decreased expression of HIF3A mRNA | CTD | PMID:24449571 | Hif3a | Mouse | metyrapone | multiple interactions | ISO | Hif3a (Rattus norvegicus) | 6480464 | Metyrapone inhibits the reaction [Ozone results in increased expression of HIF3A mRNA] | CTD | PMID:27037194 | Hif3a | Mouse | nickel atom | decreases expression | ISO | HIF3A (Homo sapiens) | 6480464 | Nickel results in decreased expression of HIF3A mRNA | CTD | PMID:24768652 and PMID:25583101 | Hif3a | Mouse | ochratoxin A | decreases expression | ISO | Hif3a (Rattus norvegicus) | 6480464 | ochratoxin A results in decreased expression of HIF3A mRNA | CTD | PMID:37162024 | Hif3a | Mouse | ochratoxin A | increases methylation | ISO | Hif3a (Rattus norvegicus) | 6480464 | ochratoxin A results in increased methylation of HIF3A gene | CTD | PMID:37162024 | Hif3a | Mouse | ozone | multiple interactions | ISO | Hif3a (Rattus norvegicus) | 6480464 | [Ozone co-treated with Particulate Matter] results in increased expression of HIF3A mRNA and Metyrapone inhibits the reaction [Ozone results in increased expression of HIF3A mRNA] | CTD | PMID:23805001 and PMID:27037194 | Hif3a | Mouse | ozone | multiple interactions | EXP | | 6480464 | [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in decreased expression of HIF3A mRNA and [Air Pollutants results in increased abundance of Ozone] which affects the expression of HIF3A mRNA | CTD | PMID:34911549 | Hif3a | Mouse | ozone | increases expression | ISO | Hif3a (Rattus norvegicus) | 6480464 | Ozone results in increased expression of HIF3A mRNA | CTD | PMID:23805001 more ... | Hif3a | Mouse | p-chloromercuribenzoic acid | multiple interactions | ISO | HIF3A (Homo sapiens) | 6480464 | [NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HIF3A mRNA | CTD | PMID:27188386 | Hif3a | Mouse | paraquat | increases expression | EXP | | 6480464 | Paraquat results in increased expression of HIF3A mRNA | CTD | PMID:21463325 | Hif3a | Mouse | phenylmercury acetate | decreases expression | ISO | HIF3A (Homo sapiens) | 6480464 | Phenylmercuric Acetate results in decreased expression of HIF3A mRNA | CTD | PMID:26272509 | Hif3a | Mouse | phenylmercury acetate | multiple interactions | ISO | HIF3A (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HIF3A mRNA | CTD | PMID:27188386 | Hif3a | Mouse | pioglitazone | decreases expression | ISO | Hif3a (Rattus norvegicus) | 6480464 | pioglitazone results in decreased expression of HIF3A mRNA | CTD | PMID:22456468 | Hif3a | Mouse | pirinixic acid | decreases expression | EXP | | 6480464 | pirinixic acid results in decreased expression of HIF3A mRNA | CTD | PMID:23811191 | Hif3a | Mouse | pregnenolone 16alpha-carbonitrile | increases expression | EXP | | 6480464 | Pregnenolone Carbonitrile results in increased expression of HIF3A mRNA | CTD | PMID:28903501 | Hif3a | Mouse | pyrethrins | decreases expression | ISO | Hif3a (Rattus norvegicus) | 6480464 | Pyrethrins results in decreased expression of HIF3A protein | CTD | PMID:34896426 | Hif3a | Mouse | resveratrol | multiple interactions | ISO | HIF3A (Homo sapiens) | 6480464 | [Plant Extracts co-treated with Resveratrol] results in decreased expression of HIF3A mRNA | CTD | PMID:23557933 | Hif3a | Mouse | SB 431542 | multiple interactions | ISO | HIF3A (Homo sapiens) | 6480464 | [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | Hif3a | Mouse | silicon dioxide | decreases expression | ISO | HIF3A (Homo sapiens) | 6480464 | Silicon Dioxide results in decreased expression of HIF3A mRNA | CTD | PMID:22300531 | Hif3a | Mouse | sunitinib | increases expression | ISO | HIF3A (Homo sapiens) | 6480464 | Sunitinib results in increased expression of HIF3A mRNA | CTD | PMID:31533062 | Hif3a | Mouse | thimerosal | decreases expression | ISO | HIF3A (Homo sapiens) | 6480464 | Thimerosal results in decreased expression of HIF3A mRNA | CTD | PMID:27188386 | Hif3a | Mouse | trichostatin A | decreases expression | ISO | HIF3A (Homo sapiens) | 6480464 | trichostatin A results in decreased expression of HIF3A mRNA | CTD | PMID:24935251 and PMID:26272509 | Hif3a | Mouse | trichostatin A | multiple interactions | ISO | HIF3A (Homo sapiens) | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HIF3A mRNA | CTD | PMID:27188386 | Hif3a | Mouse | valproic acid | increases methylation | ISO | HIF3A (Homo sapiens) | 6480464 | Valproic Acid results in increased methylation of HIF3A gene | CTD | PMID:29154799 | Hif3a | Mouse | valproic acid | increases expression | EXP | | 6480464 | Valproic Acid results in increased expression of HIF3A mRNA | CTD | PMID:21427059 | Hif3a | Mouse | valproic acid | affects expression | ISO | HIF3A (Homo sapiens) | 6480464 | Valproic Acid affects the expression of HIF3A mRNA | CTD | PMID:25979313 | Hif3a | Mouse | valproic acid | decreases expression | ISO | HIF3A (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of HIF3A mRNA | CTD | PMID:23179753 more ... | Hif3a | Mouse | valproic acid | multiple interactions | ISO | HIF3A (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HIF3A mRNA | CTD | PMID:27188386 | Hif3a | Mouse | vorinostat | decreases expression | ISO | HIF3A (Homo sapiens) | 6480464 | vorinostat results in decreased expression of HIF3A mRNA | CTD | PMID:27188386 | |