Tmed6 (transmembrane p24 trafficking protein 6) - Rat Genome Database
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Gene: Tmed6 (transmembrane p24 trafficking protein 6) Mus musculus
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Symbol: Tmed6
Name: transmembrane p24 trafficking protein 6
RGD ID: 1553422
Description: Predicted to be involved in Golgi organization; endoplasmic reticulum to Golgi vesicle-mediated transport; and intracellular protein transport. Predicted to localize to several cellular components, including COPII-coated ER to Golgi transport vesicle; Golgi apparatus; and endoplasmic reticulum-Golgi intermediate compartment. Is expressed in pancreas tip epithelium. Orthologous to human TMED6 (transmembrane p24 trafficking protein 6); INTERACTS WITH Benzo[ghi]perylene; genistein; GW 4064.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 1810015P03Rik; 1810018I24Rik; MGC107643; p24 family protein gamma-5; p24gamma5; transmembrane emp24 domain-containing protein 6; transmembrane emp24 protein transport domain containing 6
Orthologs:
Homo sapiens (human) : TMED6 (transmembrane p24 trafficking protein 6)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Tmed6 (transmembrane p24 trafficking protein 6)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tmed6 (transmembrane p24 trafficking protein 6)
Pan paniscus (bonobo/pygmy chimpanzee) : TMED6 (transmembrane p24 trafficking protein 6)
Canis lupus familiaris (dog) : TMED6 (transmembrane p24 trafficking protein 6)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tmed6 (transmembrane p24 trafficking protein 6)
Sus scrofa (pig) : TMED6 (transmembrane p24 trafficking protein 6)
Chlorocebus sabaeus (African green monkey) : TMED6 (transmembrane p24 trafficking protein 6)
Heterocephalus glaber (naked mole-rat) : Tmed6 (transmembrane p24 trafficking protein 6)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398107,788,116 - 107,792,276 (-)NCBI
GRCm388107,061,484 - 107,065,644 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8107,061,476 - 107,065,644 (-)EnsemblGRCm38mm10GRCm38
MGSCv378109,585,384 - 109,589,544 (-)NCBIGRCm37mm9NCBIm37
MGSCv368109,950,613 - 109,954,773 (-)NCBImm8
Celera8111,288,213 - 111,292,349 (-)NCBICelera
Cytogenetic Map8D3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:12477932   PMID:15489334   PMID:16141072   PMID:16141073   PMID:18554416   PMID:21873635   PMID:22129529  


Genomics

Comparative Map Data
Tmed6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398107,788,116 - 107,792,276 (-)NCBI
GRCm388107,061,484 - 107,065,644 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8107,061,476 - 107,065,644 (-)EnsemblGRCm38mm10GRCm38
MGSCv378109,585,384 - 109,589,544 (-)NCBIGRCm37mm9NCBIm37
MGSCv368109,950,613 - 109,954,773 (-)NCBImm8
Celera8111,288,213 - 111,292,349 (-)NCBICelera
Cytogenetic Map8D3NCBI
TMED6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1669,343,250 - 69,351,786 (-)EnsemblGRCh38hg38GRCh38
GRCh381669,343,250 - 69,351,786 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371669,377,149 - 69,385,712 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361667,934,661 - 67,943,190 (-)NCBINCBI36hg18NCBI36
Build 341667,934,660 - 67,943,190NCBI
Celera1653,891,689 - 53,900,252 (-)NCBI
Cytogenetic Map16q22.1NCBI
HuRef1655,254,923 - 55,263,485 (-)NCBIHuRef
CHM1_11670,785,165 - 70,793,728 (-)NCBICHM1_1
Tmed6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01939,261,841 - 39,267,928 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1939,261,841 - 39,267,928 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01950,125,752 - 50,132,047 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41936,919,407 - 36,925,919 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11936,924,402 - 36,930,795 (-)NCBI
Celera1934,390,446 - 34,396,533 (-)NCBICelera
Cytogenetic Map19q12NCBI
Tmed6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554847,346,942 - 7,354,695 (+)NCBIChiLan1.0ChiLan1.0
TMED6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11669,103,720 - 69,112,535 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v01649,717,583 - 49,726,836 (-)NCBIMhudiblu_PPA_v0panPan3
TMED6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1580,305,804 - 80,313,307 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Tmed6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493647519,459,873 - 19,468,747 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TMED6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1617,633,653 - 17,641,915 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2616,580,399 - 16,588,628 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TMED6
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1558,054,903 - 58,063,685 (+)NCBI
Tmed6
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474617,024,204 - 17,031,358 (+)NCBI


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832016544117238700Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined834642776114837007Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837400000109600000Mouse
4142023W3q5_mweight 3 weeks QTL 5 (mouse)Not determined71287817123895615Mouse
1357708Orq1_movulation rate QTL 1 (mouse)Not determined871287817123895615Mouse
1300920Pitm3_mprion incubation time 3 (mouse)Not determined873202495107202598Mouse
27095912Pglq14_mpelvic girdle length QTL 14, 16 week (mouse)873400000126100000Mouse
1558890Lith18_mlithogenic gene 18 (mouse)Not determined875675517109675623Mouse
1357470Obq16_mobesity QTL 16 (mouse)Not determined875685348109685497Mouse
1301808Nhdlq1_mnon-HDL QTL 1 (mouse)Not determined875685348109685497Mouse
1301874Hdlq16_mHDL QTL 16 (mouse)Not determined875685348109685497Mouse
10412234Nhdlq14_mnon-HDL QTL 14 (mouse)Not determined875685348109685497Mouse
1301099Cbm2_mcerebellum weight 2 (mouse)Not determined878518613112518703Mouse
1301581Char2_mP. chabaudi malaria resistance QTL 2 (mouse)Not determined879082178113082403Mouse
10755530Wbc2_mwhite blood cell count 2 (mouse)881092664115092664Mouse
10755519Wbc1_mwhite blood cell count 1 (mouse)881619151115619151Mouse
1301766Desp1_mdespair 1 (mouse)Not determined884759576118759741Mouse
1302049Heal1_mwound healing/regeneration 1 (mouse)Not determined885716921119717069Mouse
1301253Skmw2_mskeletal muscle weight 2 (mouse)Not determined885716921119717069Mouse
10045619Heal14_mwound healing/regeneration 14 (mouse)Not determined885716921119717069Mouse
27226796Scvln16_msacral vertebrae length 2, 16 week (mouse)889000000130800000Mouse
1357494Obsty2_mobesity 2 (mouse)Not determined895518613129018580Mouse
12880431Fgf23lq2_mFGF23 serum level QTL 2 (mouse)896900000129401213Mouse
11252141Fdr2_mfat response to dietary restriction 2 (mouse)897663894129401213Mouse
1301481Lith11_mlithogenic gene 11 (mouse)Not determined897836895129401213Mouse
1301080Sluc9_msusceptibility to lung cancer 9 (mouse)Not determined899101792129401213Mouse
1302105Im1_mImmunoregulatory 1 (mouse)Not determined899101792129401213Mouse
4141435Fbtq3_mfemoral bone trait QTL 3 (mouse)Not determined8100238570129401213Mouse
1300560Tgl1_mtriglyceride level 1 (mouse)Not determined8101759576110923404Mouse
1300681Pgia22_mproteoglycan induced arthritis 22 (mouse)Not determined8101759576115298718Mouse
1301316Dntcs1_mdental caries susceptibility 1 (mouse)Not determined8102716921127055036Mouse
11532691Sluc38_msusceptibility to lung cancer 38 (mouse)8104307238129401213Mouse
11532692Sluc38a_msusceptibility to lung cancer 38a (mouse)8104307238129401213Mouse
14746994Manh65_mmandible shape 65 (mouse)8105762890129401213Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:130
Count of miRNA genes:117
Interacting mature miRNAs:129
Transcripts:ENSMUST00000034393
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000034393   ⟹   ENSMUSP00000034393
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl8107,061,476 - 107,065,644 (-)Ensembl
RefSeq Acc Id: NM_025458   ⟹   NP_079734
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm398107,788,116 - 107,792,276 (-)NCBI
GRCm388107,061,484 - 107,065,644 (-)ENTREZGENE
MGSCv378109,585,384 - 109,589,544 (-)RGD
Celera8111,288,213 - 111,292,349 (-)RGD
cM Map8 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_079734   ⟸   NM_025458
- Peptide Label: precursor
- UniProtKB: Q9CQG0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000034393   ⟸   ENSMUST00000034393
Protein Domains
GOLD

Promoters
RGD ID:8668205
Promoter ID:EPDNEW_M12133
Type:multiple initiation site
Name:Tmed6_1
Description:Mus musculus transmembrane p24 trafficking protein 6 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm388107,065,639 - 107,065,699EPDNEW
RGD ID:6843812
Promoter ID:MM_KWN:55642
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   Kidney
Transcripts:NM_025458
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv368109,589,336 - 109,589,836 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1913519 AgrOrtholog
Ensembl Genes ENSMUSG00000031919 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000034393 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000034393 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro GOLD_dom UniProtKB/Swiss-Prot
  TMP21-related UniProtKB/Swiss-Prot
KEGG Report mmu:66269 UniProtKB/Swiss-Prot
MGD MGI:1913519 ENTREZGENE
NCBI Gene 66269 ENTREZGENE
PANTHER PTHR22811 UniProtKB/Swiss-Prot
Pfam EMP24_GP25L UniProtKB/Swiss-Prot
PhenoGen Tmed6 PhenoGen
PROSITE GOLD UniProtKB/Swiss-Prot
SMART EMP24_GP25L UniProtKB/Swiss-Prot
UniGene Mm.23032 ENTREZGENE
UniProt Q9CQG0 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-10-04 Tmed6  transmembrane p24 trafficking protein 6    transmembrane emp24 protein transport domain containing 6  Symbol and/or name change 5135510 APPROVED