Adgrf4 (adhesion G protein-coupled receptor F4) - Rat Genome Database

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Gene: Adgrf4 (adhesion G protein-coupled receptor F4) Mus musculus
Analyze
Symbol: Adgrf4
Name: adhesion G protein-coupled receptor F4
RGD ID: 1315497
MGI Page MGI
Description: Predicted to enable G protein-coupled receptor activity. Acts upstream of or within erythrocyte development; glomerular filtration; and pharyngeal arch artery morphogenesis. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in several structures, including genitourinary system; heart; lung; skin; and thymus. Orthologous to human ADGRF4 (adhesion G protein-coupled receptor F4); INTERACTS WITH Benzo[k]fluoranthene; GW 4064; triptonide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 4632435A09Rik; AV239010; G protein coupled receptor Gpr115; G protein-coupled receptor 115; G-protein coupled receptor 115; Gpr1; Gpr115; MGC107333; MGC175941; probable G-protein coupled receptor 115
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391742,967,099 - 43,008,460 (-)NCBIGRCm39mm39
GRCm39 Ensembl1742,967,782 - 43,003,175 (-)Ensembl
GRCm381742,656,208 - 42,697,569 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1742,656,891 - 42,692,284 (-)EnsemblGRCm38mm10GRCm38
MGSCv371742,793,840 - 42,829,233 (-)NCBIGRCm37mm9NCBIm37
MGSCv361742,120,371 - 42,155,768 (-)NCBImm8
Celera1746,077,195 - 46,113,100 (-)NCBICelera
Cytogenetic Map17B3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:12477932   PMID:16141072   PMID:16141073   PMID:21267068   PMID:21677750   PMID:22837050   PMID:24194600   PMID:25713288   PMID:28806758  
PMID:32868297  


Genomics

Comparative Map Data
Adgrf4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391742,967,099 - 43,008,460 (-)NCBIGRCm39mm39
GRCm39 Ensembl1742,967,782 - 43,003,175 (-)Ensembl
GRCm381742,656,208 - 42,697,569 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1742,656,891 - 42,692,284 (-)EnsemblGRCm38mm10GRCm38
MGSCv371742,793,840 - 42,829,233 (-)NCBIGRCm37mm9NCBIm37
MGSCv361742,120,371 - 42,155,768 (-)NCBImm8
Celera1746,077,195 - 46,113,100 (-)NCBICelera
Cytogenetic Map17B3NCBI
ADGRF4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl647,685,864 - 47,722,021 (+)EnsemblGRCh38hg38GRCh38
GRCh38647,698,580 - 47,722,014 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37647,666,316 - 47,689,750 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36647,774,248 - 47,797,716 (+)NCBINCBI36hg18NCBI36
Build 34647,761,558 - 47,794,135NCBI
Celera649,222,549 - 49,246,023 (+)NCBI
Cytogenetic Map6p12.3NCBI
HuRef647,394,206 - 47,417,677 (+)NCBIHuRef
CHM1_1647,669,245 - 47,692,709 (+)NCBICHM1_1
Adgrf4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2918,272,050 - 18,303,219 (+)NCBI
Rnor_6.0 Ensembl920,951,260 - 20,982,487 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0920,951,249 - 20,982,493 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0919,813,518 - 19,843,615 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4914,006,763 - 14,122,217 (+)NCBIRGSC3.4rn4RGSC3.4
Celera915,974,864 - 16,005,898 (+)NCBICelera
Cytogenetic Map9q13NCBI
Adgrf4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543712,127,361 - 12,147,346 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543712,127,365 - 12,147,227 (+)NCBIChiLan1.0ChiLan1.0
ADGRF4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1648,545,376 - 48,568,891 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl648,532,763 - 48,565,317 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0647,279,791 - 47,305,196 (+)NCBIMhudiblu_PPA_v0panPan3
ADGRF4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11215,740,427 - 15,771,939 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1215,741,534 - 15,771,948 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1215,771,250 - 15,779,068 (+)NCBI
ROS_Cfam_1.01216,242,995 - 16,274,295 (+)NCBI
UMICH_Zoey_3.11215,752,448 - 15,783,737 (+)NCBI
UNSW_CanFamBas_1.01215,844,924 - 15,876,192 (+)NCBI
UU_Cfam_GSD_1.01215,992,597 - 16,023,878 (+)NCBI
Adgrf4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494651,123,890 - 51,147,260 (+)NCBI
SpeTri2.0NW_00493647612,814,919 - 12,827,974 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADGRF4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl742,373,211 - 42,430,700 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1742,404,522 - 42,430,271 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2392,062,828 - 92,088,464 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ADGRF4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11724,546,272 - 24,594,430 (-)NCBI
ChlSab1.1 Ensembl1724,570,790 - 24,582,638 (-)Ensembl
Vero_WHO_p1.0NW_02366604447,703,864 - 47,757,035 (+)NCBI
Adgrf4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475413,363,968 - 13,382,630 (-)NCBI

Position Markers
D18369  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381742,656,929 - 42,657,115UniSTSGRCm38
MGSCv371742,793,878 - 42,794,064UniSTSGRCm37
Celera1746,077,233 - 46,077,419UniSTS
Celera1746,072,556 - 46,072,741UniSTS
Cytogenetic Map17B3UniSTS
Whitehead_YAC17 UniSTS
AV239010  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381742,656,998 - 42,657,115UniSTSGRCm38
MGSCv371742,793,947 - 42,794,064UniSTSGRCm37
Celera1746,077,302 - 46,077,419UniSTS
Cytogenetic Map17B3UniSTS
Whitehead/MRC_RH17547.08UniSTS
Gpr115  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map17B3UniSTS
cM Map1719.65UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300890Bhr3_mbronchial hyperresponsiveness 3 (mouse)Not determined17392461548559063Mouse
4141215Mnic1_mmacronutrient intake, carbohydrate 1 (mouse)Not determined480447745359340Mouse
1300706Alan1_malloantigen response 1 (mouse)Not determined17480447746158776Mouse
1357789Kdnw3_mkidney weight 3 (mouse)Not determined17480447747574740Mouse
4141272Tfv1_mtotal food volume 1 (mouse)Not determined480447765330362Mouse
1301338Lmr1_mleishmaniasis resistance 1 (mouse)Not determined17986241186688972Mouse
1302028Asbb3_mautoimmune susceptibility in C57BL/6J and BALB/c 3 (mouse)Not determined171065914544659245Mouse
4141067Hbnr2_mHeligmosomoides bakeri nematode resistance 2 (mouse)Not determined1166699745667145Mouse
14747010Mancz14_mmandible centroid size 14 (mouse)171177921045779210Mouse
4142150Stheal11_msoft tissue heal 11 (mouse)Not determined171206732483054339Mouse
12904946Tammq8_mtibialis anterior muscle mass QTL 8 (mouse)171223281346232813Mouse
13524847Asrq8a_macoustic startle response 8a (mouse)171242798746427987Mouse
11081168Tir7_mtrypanosome infection response 7 (mouse)171390439847904522Mouse
1300914Pcir4_mperiosteal circumference 4 (mouse)Not determined171484267848842786Mouse
1558886Lgth9_mbody length 9 (mouse)Not determined171484267848842786Mouse
1302070Tbbmd7_mtotal body bone mineral density 7 (mouse)Not determined171484267848842786Mouse
1300995Fembrs4_mfemur breaking strength 4 (mouse)Not determined171484267848842786Mouse
1302140Wta4_mweight adult 4 (mouse)Not determined171660074750600869Mouse
1302152Skull25_mskull morphology 25 (mouse)Not determined171660074750600869Mouse
1301505Tir1_mtrypanosome infection response 1 (mouse)Not determined171660074750600869Mouse
10412083Sm2_msusceptibility to Schistosoma mansoni infection 2 (mouse)Not determined171681096950811104Mouse
1302042Acsns3_mAngiostrongylus costaricensis nematode susceptibility 3 (mouse)Not determined171724323451243371Mouse
1300535Char3_mP. chabaudi malaria resistance QTL 3 (mouse)Not determined171724323451243371Mouse
10412214Sxbq3_mSGC/Knj cross B6 QTL 3 (mouse)Not determined171724323451243371Mouse
13452396Leusq3_mleucocytosis susceptibility QTL 3 (mouse)171724323451243371Mouse
13452399Leusq6_mleucocytosis susceptibility QTL 6 (mouse)171724323451243371Mouse
1301840Ssial4_msusceptibility to sialadenitiss 4 (mouse)Not determined171795643651959238Mouse
1301331Lbw1_mlupus NZB x NZW 1 (mouse)Not determined171819938152202007Mouse
1301056Pas2_mpulmonary adenoma susceptibility 2 (mouse)Not determined171820316552205351Mouse
15039354Nmrs36_mNAFLD-associated magnetic resonance shift 36 (mouse)171883413352834133Mouse
1301454Eae5_msusceptibility to experimental allergic encephalomyelitis 5 (mouse)Not determined172430185958301973Mouse
10412198Sst5_msusceptibility to tuberculosis 5 (mouse)Not determined172485760955405969Mouse
10412196Bbaa28_mB.burgdorferi-associated arthritis 28 (mouse)Not determined172536594043665344Mouse
10412204Bbaa29_mB.burgdorferi-associated arthritis 29 (mouse)Not determined172574029459740461Mouse
1558758Kcal2_mkilocalorie 2 (mouse)Not determined172618203852604676Mouse
1302005Loco2_mlocomotor activity 2 (mouse)Not determined172657408160574223Mouse
11075105Modc1_mmodifier of Odc1 (mouse)172749681845311728Mouse
15039348Nmrs37_mNAFLD-associated magnetic resonance shift 37 (mouse)172750432261504322Mouse
10045977Tir9_mtrypanosome infection response 9 (mouse)Not determined172765914543574223Mouse
1300703Uvbi2_mUVB induced immunosuppression 2 (mouse)Not determined172831148062311728Mouse
1300589Myaa2_mmodifier of Yaa 2 (mouse)Not determined172982162963821740Mouse
4140955Plgr1_mplague resistance locus 1 (mouse)Not determined3072257564722705Mouse
4141357Mrdq1_mmodifier of retinal degeneration QTL 1 (mouse)Not determined3076892947728778Mouse
26884379Skwq5_mskull length QTL 5, 5 week (mouse)173290000053800000Mouse
1300885Mbis4_mMycobacterium bovis-induced systemic lupus erythematosus 4 (mouse)Not determined173495684169858931Mouse
10755514Amzn2_manatomical modifier of Zfp423 2 (mouse)173565926669659396Mouse
12904951Smmq2_msoleus muscle mass QTL 2 (mouse)173648271570482715Mouse
1301474Hcbip2_mhexachlorobenzene induced porphyria 2 (mouse)Not determined173748216445311728Mouse
1300592Pcyts5_mplasmacytoma susceptibility 5 (mouse)Not determined173840588672405969Mouse
10755525Lymph2_mlymphocyte differential 2 (mouse)173849862572498625Mouse
10755534Lymph4_mlymphocyte differential 4 (mouse)173849862572498625Mouse
4141319Hmtb8_mhemostasis and thrombosis rebleeding time 8 (mouse)Not determined4022744774227623Mouse
15039324Nmrs48_mNAFLD-associated magnetic resonance shift 48 (mouse)174063218774632187Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:818
Count of miRNA genes:259
Interacting mature miRNAs:293
Transcripts:ENSMUST00000024711, ENSMUST00000164524, ENSMUST00000167993, ENSMUST00000170723
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000024711   ⟹   ENSMUSP00000024711
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1742,656,891 - 42,692,284 (-)Ensembl
RefSeq Acc Id: ENSMUST00000164524   ⟹   ENSMUSP00000129114
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1742,672,588 - 42,692,273 (-)Ensembl
RefSeq Acc Id: ENSMUST00000167993   ⟹   ENSMUSP00000132890
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1742,656,894 - 42,692,284 (-)Ensembl
RefSeq Acc Id: ENSMUST00000170723   ⟹   ENSMUSP00000133261
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1742,657,091 - 42,692,262 (-)Ensembl
RefSeq Acc Id: NM_001289499   ⟹   NP_001276428
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391742,967,778 - 43,003,175 (-)NCBI
GRCm381742,656,887 - 42,692,284 (-)NCBI
Celera1746,077,191 - 46,113,100 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001289500   ⟹   NP_001276429
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391742,967,778 - 43,003,175 (-)NCBI
GRCm381742,656,887 - 42,692,284 (-)NCBI
Celera1746,077,191 - 46,113,100 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001289501   ⟹   NP_001276430
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391742,967,778 - 43,003,175 (-)NCBI
GRCm381742,656,887 - 42,692,284 (-)NCBI
Celera1746,077,191 - 46,113,100 (-)NCBI
Sequence:
RefSeq Acc Id: NM_030067   ⟹   NP_084343
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391742,967,778 - 43,003,175 (-)NCBI
GRCm381742,656,887 - 42,692,284 (-)NCBI
MGSCv371742,793,840 - 42,829,233 (-)RGD
Celera1746,077,191 - 46,113,100 (-)NCBI
cM Map17 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_017317725   ⟹   XP_017173214
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391742,967,099 - 43,008,460 (-)NCBI
GRCm381742,656,208 - 42,697,569 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_084343   ⟸   NM_030067
- Peptide Label: precursor
- UniProtKB: Q9D2L6 (UniProtKB/Swiss-Prot),   A0A0D9SEG9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001276428   ⟸   NM_001289499
- Peptide Label: precursor
- UniProtKB: Q9D2L6 (UniProtKB/Swiss-Prot),   A0A0D9SEG9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001276429   ⟸   NM_001289500
- Peptide Label: precursor
- UniProtKB: Q9D2L6 (UniProtKB/Swiss-Prot),   A0A0D9SEG9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001276430   ⟸   NM_001289501
- Peptide Label: precursor
- UniProtKB: Q9D2L6 (UniProtKB/Swiss-Prot),   A0A0D9SEG9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017173214   ⟸   XM_017317725
- Peptide Label: isoform X1
- UniProtKB: Q9D2L6 (UniProtKB/Swiss-Prot),   A0A0D9SEG9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000129114   ⟸   ENSMUST00000164524
RefSeq Acc Id: ENSMUSP00000133261   ⟸   ENSMUST00000170723
RefSeq Acc Id: ENSMUSP00000132890   ⟸   ENSMUST00000167993
RefSeq Acc Id: ENSMUSP00000024711   ⟸   ENSMUST00000024711
Protein Domains
G_PROTEIN_RECEP_F2_4   GPS

Promoters
RGD ID:13676096
Promoter ID:EPDNEW_M22197
Type:initiation region
Name:Adgrf4_1
Description:Mus musculus adhesion G protein-coupled receptor F4 , transcriptvariant 4, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381742,692,259 - 42,692,319EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1925499 AgrOrtholog
Ensembl Genes ENSMUSG00000023918 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000024711 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSP00000129114 UniProtKB/TrEMBL
  ENSMUSP00000132890 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSP00000133261 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000024711 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000164524 UniProtKB/TrEMBL
  ENSMUST00000167993 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000170723 ENTREZGENE, UniProtKB/TrEMBL
InterPro GPCR_2-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2_Ig-hepta-like_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2_secretin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:78249 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1925499 ENTREZGENE
NCBI Gene 78249 ENTREZGENE
Pfam 7tm_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Adgrf4 PhenoGen
PRINTS GPCRSECRETIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IGHEPTARCPTR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F2_4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART GPS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0D9SEG9 ENTREZGENE, UniProtKB/TrEMBL
  AGRF4_MOUSE UniProtKB/Swiss-Prot
  B2RU58_MOUSE UniProtKB/TrEMBL
  E9PYI0_MOUSE UniProtKB/TrEMBL
  Q9D2L6 ENTREZGENE
UniProt Secondary Q5FW81 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-03-19 Adgrf4  adhesion G protein-coupled receptor F4  Gpr115  G protein-coupled receptor 115  Symbol and/or name change 5135510 APPROVED