Stkld1 (serine/threonine kinase-like domain containing 1) - Rat Genome Database

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Gene: Stkld1 (serine/threonine kinase-like domain containing 1) Mus musculus
Analyze
Symbol: Stkld1
Name: serine/threonine kinase-like domain containing 1
RGD ID: 1316506
MGI Page MGI
Description: Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in protein phosphorylation. Orthologous to human STKLD1 (serine/threonine kinase like domain containing 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Gm711; likely ortholog of H. sapiens chromosome 9 open reading frame 96 (C9orf96); MGC58758; probable inactive protein kinase-like protein SgK071 homolog; probable protein kinase-like protein SgK071 homolog; RP23-414L19.8; serine/threonine kinase-like domain-containing protein 1; serine/threonine kinase-like domain-containing protein STKLD1; Sgk071; sugen kinase 071
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39226,823,533 - 26,843,508 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl226,824,059 - 26,843,508 (+)EnsemblGRCm39 Ensembl
GRCm38226,933,521 - 26,953,496 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl226,934,047 - 26,953,496 (+)EnsemblGRCm38mm10GRCm38
MGSCv37226,789,589 - 26,809,016 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36226,756,078 - 26,775,505 (+)NCBIMGSCv36mm8
Celera226,643,814 - 26,663,241 (+)NCBICelera
Cytogenetic Map2A3NCBI
cM Map219.12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:14610273   PMID:21267068   PMID:21873635  


Genomics

Comparative Map Data
Stkld1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39226,823,533 - 26,843,508 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl226,824,059 - 26,843,508 (+)EnsemblGRCm39 Ensembl
GRCm38226,933,521 - 26,953,496 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl226,934,047 - 26,953,496 (+)EnsemblGRCm38mm10GRCm38
MGSCv37226,789,589 - 26,809,016 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36226,756,078 - 26,775,505 (+)NCBIMGSCv36mm8
Celera226,643,814 - 26,663,241 (+)NCBICelera
Cytogenetic Map2A3NCBI
cM Map219.12NCBI
STKLD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389133,376,366 - 133,406,096 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9133,376,366 - 133,406,096 (+)EnsemblGRCh38hg38GRCh38
GRCh379136,243,237 - 136,271,220 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369135,233,105 - 135,261,041 (+)NCBINCBI36Build 36hg18NCBI36
Build 349133,272,837 - 133,300,773NCBI
Celera9106,793,768 - 106,821,789 (+)NCBICelera
Cytogenetic Map9q34.2NCBI
HuRef9105,743,194 - 105,773,047 (+)NCBIHuRef
CHM1_19136,393,410 - 136,421,727 (+)NCBICHM1_1
T2T-CHM13v2.09145,590,326 - 145,620,528 (+)NCBIT2T-CHM13v2.0
Stkld1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8330,659,659 - 30,678,650 (+)NCBIGRCr8
mRatBN7.2310,261,583 - 10,280,850 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl310,261,828 - 10,280,566 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx313,321,826 - 13,340,565 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0321,907,227 - 21,925,966 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0320,162,528 - 20,181,267 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.035,481,524 - 5,500,568 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl35,481,522 - 5,500,583 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0310,843,542 - 10,863,228 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.435,830,687 - 5,849,484 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.135,836,030 - 5,850,402 (+)NCBI
Celera35,059,877 - 5,078,674 (+)NCBICelera
Cytogenetic Map3p13NCBI
Stkld1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555132,726,339 - 2,744,998 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555132,726,339 - 2,745,099 (+)NCBIChiLan1.0ChiLan1.0
STKLD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2115,947,714 - 5,977,020 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan195,950,050 - 5,979,360 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v09104,499,706 - 104,528,872 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19133,111,802 - 133,140,430 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9133,111,802 - 133,140,430 (+)Ensemblpanpan1.1panPan2
STKLD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1949,807,272 - 49,827,611 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl949,807,250 - 49,827,567 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha949,088,729 - 49,108,851 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0950,681,212 - 50,701,368 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl950,679,931 - 50,701,324 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1949,443,623 - 49,463,762 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0949,785,100 - 49,805,262 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0949,863,140 - 49,883,340 (+)NCBIUU_Cfam_GSD_1.0
Stkld1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947199,863,554 - 199,882,555 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366693,492,615 - 3,509,583 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366693,492,507 - 3,511,297 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
STKLD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1272,995,842 - 273,011,443 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11272,988,767 - 273,012,007 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
STKLD1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1124,732,267 - 4,763,687 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl124,732,772 - 4,759,244 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666058229,313 - 257,244 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Stkld1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247601,835,478 - 1,850,864 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247601,833,797 - 1,851,379 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:311
Count of miRNA genes:253
Interacting mature miRNAs:275
Transcripts:ENSMUST00000055406, ENSMUST00000153771
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552706Cia24_mcollagen induced arthritis QTL 24 (mouse)Not determined22467911533523172Mouse
8552707Cia23_mcollagen induced arthritis QTL 23 (mouse)Not determined21212953766556453Mouse
1300624Insq7_minsulin QTL 7 (mouse)Not determined2938444643384575Mouse
8552705Cia25_mcollagen induced arthritis 25 (mouse)Not determined22467911533523172Mouse
39128209Lwq14_mliver weight QTL 14 (mouse)220897778118894840Mouse
1558738W6q1_mweight 6 weeks QTL 1 (mouse)Not determined220897778118894840Mouse
26884438Sklq12_mskull length QTL 12, 16 week (mouse)22459001254890012Mouse
1301790Pcfm1_mperiosteal circumference and femur length 1 (mouse)Not determined2823629642236396Mouse
1302174Dssc2_mdextran sodium sulfate induced colitis QTL2 (mouse)Not determined224224632148700377Mouse
4142130Pgis2_mproteoglycan induced spondylitis 2 (mouse)Not determined22530805156971811Mouse
1301980Fcsa5_mfemoral cross-sectional area 5 (mouse)Not determined2767911541679261Mouse
1301376Etohc1_methanol consumption 1 (mouse)Not determined22112972555129871Mouse
1558915W3q1_mweight 3 weeks QTL 1 (mouse)Not determined220897778118894840Mouse
12792980Fbmd1_mfemoral bone mineral density 1, females only (mouse)22503449245034492Mouse
1301769Orgwq2_morgan weight QTL 2 (mouse)Not determined2388712693421651Mouse
1301641Sbmd2_mspinal bone mineral density 2 (mouse)Not determined21421456748214713Mouse
1357454Kidq1_mkidney weight QTL 1 (mouse)Not determined220897778118894840Mouse
10755513Amzn4_manatomical modifier of Zfp423 4 (mouse)2938444643384575Mouse
1558966W10q9_mweight 10 weeks QTL 9 (mouse)Not determined220897778118894840Mouse
12904743Carcdq3_mcardiac collagen deposition QTL 3 (mouse)2323494028179150Mouse
13463470Tubisq1_mtubulointerstitial injury severity, QTL 1 (mouse)22368914557689269Mouse
1558899Egq1_mearly growth QTL 1 (mouse)Not determined220897778118894840Mouse
1357681Hrtq1_mheart weight QTL 1 (mouse)Not determined220897778118894840Mouse
1357436Splq1_mspleen weight QTL 1 (mouse)Not determined220897778118894840Mouse
1357881Estoq1_membryo survival total QTL 1 (mouse)Not determined220897778118894840Mouse
4141708Pbwg1.2_mpostnatal body weight growth 1.2 (mouse)Not determined2112972555129871Mouse
10043876Adip22_madiposity 22 (mouse)Not determined2830805142308240Mouse
12903993Opfaq1_mopen field activity QTL 1 (mouse)2967669127022642Mouse


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000055406   ⟹   ENSMUSP00000062967
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl226,824,081 - 26,843,508 (+)Ensembl
GRCm38.p6 Ensembl226,934,069 - 26,953,496 (+)Ensembl
Ensembl Acc Id: ENSMUST00000153771   ⟹   ENSMUSP00000121332
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl226,824,059 - 26,833,164 (+)Ensembl
GRCm38.p6 Ensembl226,934,047 - 26,943,152 (+)Ensembl
RefSeq Acc Id: NM_001379463   ⟹   NP_001366392
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39226,824,068 - 26,843,508 (+)NCBI
GRCm38226,934,056 - 26,953,496 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001379464   ⟹   NP_001366393
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39226,824,068 - 26,843,508 (+)NCBI
GRCm38226,934,056 - 26,953,496 (+)NCBI
Sequence:
RefSeq Acc Id: NM_198628   ⟹   NP_941030
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39226,824,068 - 26,843,508 (+)NCBI
GRCm38226,934,056 - 26,953,496 (+)NCBI
MGSCv37226,789,589 - 26,809,016 (+)RGD
Celera226,643,814 - 26,663,241 (+)RGD
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006498107   ⟹   XP_006498170
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39226,824,151 - 26,843,508 (+)NCBI
GRCm38226,934,139 - 26,953,496 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006498108   ⟹   XP_006498171
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39226,824,153 - 26,843,508 (+)NCBI
GRCm38226,934,140 - 26,953,496 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006498109   ⟹   XP_006498172
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39226,824,003 - 26,843,508 (+)NCBI
GRCm38226,933,790 - 26,953,496 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006498110   ⟹   XP_006498173
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39226,823,533 - 26,843,508 (+)NCBI
GRCm38226,933,521 - 26,953,496 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006498111   ⟹   XP_006498174
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39226,824,154 - 26,843,508 (+)NCBI
GRCm38226,934,141 - 26,953,496 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006498112   ⟹   XP_006498175
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39226,824,151 - 26,843,508 (+)NCBI
GRCm38226,934,138 - 26,953,496 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006498113   ⟹   XP_006498176
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39226,824,156 - 26,843,508 (+)NCBI
GRCm38226,934,143 - 26,953,496 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006498114   ⟹   XP_006498177
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39226,833,171 - 26,843,508 (+)NCBI
GRCm38226,943,159 - 26,953,496 (+)NCBI
Sequence:
RefSeq Acc Id: NP_941030   ⟸   NM_198628
- Peptide Label: isoform 2
- UniProtKB: A2ALB0 (UniProtKB/Swiss-Prot),   Q80YS9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006498173   ⟸   XM_006498110
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006498172   ⟸   XM_006498109
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_006498170   ⟸   XM_006498107
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006498175   ⟸   XM_006498112
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_006498174   ⟸   XM_006498111
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_006498171   ⟸   XM_006498108
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006498176   ⟸   XM_006498113
- Peptide Label: isoform X6
- UniProtKB: A2ALB0 (UniProtKB/Swiss-Prot),   Q80YS9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006498177   ⟸   XM_006498114
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: NP_001366392   ⟸   NM_001379463
- Peptide Label: isoform 1
RefSeq Acc Id: NP_001366393   ⟸   NM_001379464
- Peptide Label: isoform 3
Ensembl Acc Id: ENSMUSP00000121332   ⟸   ENSMUST00000153771
Ensembl Acc Id: ENSMUSP00000062967   ⟸   ENSMUST00000055406
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q80YS9-F1-model_v2 AlphaFold Q80YS9 1-662 view protein structure

Promoters
RGD ID:6832549
Promoter ID:MM_KWN:28318
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_198628,   OTTMUST00000027530,   OTTMUST00000027531,   OTTMUST00000078118,   UC008IWL.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36226,788,821 - 26,789,562 (+)MPROMDB
RGD ID:6876736
Promoter ID:EPDNEW_M1819
Type:initiation region
Name:Stkld1_1
Description:Mus musculus serine/threonine kinase-like domain containing 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38226,934,066 - 26,934,126EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2685557 AgrOrtholog
Ensembl Genes ENSMUSG00000049897 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000055406 ENTREZGENE
  ENSMUST00000055406.9 UniProtKB/Swiss-Prot
  ENSMUST00000153771.8 UniProtKB/TrEMBL
Gene3D-CATH 1.25.10.10 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ARM-like UniProtKB/Swiss-Prot
  ARM-type_fold UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:279029 UniProtKB/Swiss-Prot
MGD MGI:2685557 ENTREZGENE
NCBI Gene 279029 ENTREZGENE
PANTHER SERINE/THREONINE KINASE-LIKE DOMAIN-CONTAINING PROTEIN STKLD1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SERINE/THREONINE PROTEIN KINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/Swiss-Prot
PhenoGen Stkld1 PhenoGen
PROSITE PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48371 UniProtKB/Swiss-Prot
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A2ALB0 ENTREZGENE
  B0R044_MOUSE UniProtKB/TrEMBL
  Q80YS9 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary A2ALB0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-07-01 Stkld1  serine/threonine kinase-like domain containing 1  Gm711  predicted gene 711  Symbol and/or name change 5135510 APPROVED