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Gene: Rfx5 (regulatory factor X, 5 (influences HLA class II expression)) Mus musculus
Symbol: Rfx5
Name: regulatory factor X, 5 (influences HLA class II expression)
Description: Predicted to have DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Predicted to localize to nucleus. Is expressed in several structures, including branchial arch; eye; genitourinary system; heart; and nervous system. Human ortholog(s) of this gene implicated in MHC class II deficiency and severe combined immunodeficiency. Orthologous to human RFX5 (regulatory factor X5); PARTICIPATES IN antigen processing and presentation pathway; primary immunodeficiency pathway; tuberculosis pathway; INTERACTS WITH 2,2',4,4',5,5'-hexachlorobiphenyl; 2,2',5,5'-tetrachlorobiphenyl; 4-hydroxyphenyl retinamide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: DNA-binding protein Rfx5; regulatory factor X 5; regulatory factor X, 5
Homo sapiens (human) : RFX5 (regulatory factor X5)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Rfx5 (regulatory factor X5)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Rfx5 (regulatory factor X5)
Pan paniscus (bonobo/pygmy chimpanzee) : RFX5 (regulatory factor X5)
Canis lupus familiaris (dog) : RFX5 (regulatory factor X5)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Rfx5 (regulatory factor X5)
Sus scrofa (pig) : RFX5 (regulatory factor X5)
Chlorocebus sabaeus (African green monkey) : RFX5 (regulatory factor X5)
Heterocephalus glaber (naked mole-rat) : Rfx5 (regulatory factor X5)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl394,954,075 - 94,961,561 (+)EnsemblGRCm38mm10GRCm38
GRCm38394,950,689 - 94,961,561 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37394,758,937 - 94,765,483 (+)NCBIGRCm37mm9NCBIm37
MGSCv36395,039,585 - 95,046,965 (+)NCBImm8
Celera396,386,303 - 96,392,849 (+)NCBICelera
Cytogenetic Map3F2.1NCBI
cM Map340.74NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Rfx5
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1323260
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.