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Gene: Rfx5 (regulatory factor X, 5 (influences HLA class II expression)) Mus musculus
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Symbol: Rfx5
Name: regulatory factor X, 5 (influences HLA class II expression)
Description: Predicted to have DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Predicted to localize to nucleus. Is expressed in several structures, including branchial arch; eye; genitourinary system; heart; and nervous system. Human ortholog(s) of this gene implicated in MHC class II deficiency and severe combined immunodeficiency. Orthologous to human RFX5 (regulatory factor X5); PARTICIPATES IN antigen processing and presentation pathway; primary immunodeficiency pathway; tuberculosis pathway; INTERACTS WITH 2,2',4,4',5,5'-hexachlorobiphenyl; 2,2',5,5'-tetrachlorobiphenyl; 4-hydroxyphenyl retinamide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: DNA-binding protein Rfx5; regulatory factor X 5; regulatory factor X, 5
Orthologs:
Homo sapiens (human) : RFX5 (regulatory factor X5)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Rfx5 (regulatory factor X5)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Rfx5 (regulatory factor X5)
Pan paniscus (bonobo/pygmy chimpanzee) : RFX5 (regulatory factor X5)
Canis lupus familiaris (dog) : RFX5 (regulatory factor X5)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Rfx5 (regulatory factor X5)
Sus scrofa (pig) : RFX5 (regulatory factor X5)
Chlorocebus sabaeus (African green monkey) : RFX5 (regulatory factor X5)
Heterocephalus glaber (naked mole-rat) : Rfx5 (regulatory factor X5)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl394,954,075 - 94,961,561 (+)EnsemblGRCm38mm10GRCm38
GRCm38394,950,689 - 94,961,561 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37394,758,937 - 94,765,483 (+)NCBIGRCm37mm9NCBIm37
MGSCv36395,039,585 - 95,046,965 (+)NCBImm8
Celera396,386,303 - 96,392,849 (+)NCBICelera
Cytogenetic Map3F2.1NCBI
cM Map340.74NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Rfx5
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1323260
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.