Acot4 Mouse 1,1-dichloroethene decreases expression EXP 6480464 vinylidene chloride results in decreased expression of ACOT4 mRNA CTD PMID:26682919 Acot4 Mouse 1,2-dimethylhydrazine decreases expression EXP 6480464 1 and 2-Dimethylhydrazine results in decreased expression of ACOT4 mRNA CTD PMID:22206623 Acot4 Mouse 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions EXP 6480464 [2 more ... CTD PMID:25510870 and PMID:28433925 Acot4 Mouse 2,2',4,4'-Tetrabromodiphenyl ether increases expression ISO Acot4 (Rattus norvegicus) 6480464 2 more ... CTD PMID:31826744 Acot4 Mouse 2,2',5,5'-tetrachlorobiphenyl multiple interactions EXP 6480464 [2 more ... CTD PMID:25510870 Acot4 Mouse 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of ACOT4 mRNA CTD PMID:20702594 Acot4 Mouse 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP 6480464 [Tetrachlorodibenzodioxin co-treated with 2 more ... CTD PMID:28433925 Acot4 Mouse 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of ACOT4 mRNA CTD PMID:26290441 and PMID:28922406 Acot4 Mouse 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO Acot4 (Rattus norvegicus) 6480464 Tetrachlorodibenzodioxin results in decreased expression of ACOT4 mRNA CTD PMID:21215274 more ... Acot4 Mouse 2,3,7,8-Tetrachlorodibenzofuran affects expression EXP 6480464 2 more ... CTD PMID:20702594 Acot4 Mouse 4,4'-sulfonyldiphenol multiple interactions ISO Acot4 (Rattus norvegicus) 6480464 [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of ACOT4 mRNA CTD PMID:36041667 Acot4 Mouse 4-hydroxyphenyl retinamide increases expression EXP 6480464 Fenretinide results in increased expression of ACOT4 mRNA CTD PMID:28973697 Acot4 Mouse 5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole affects expression ISO Acot4 (Rattus norvegicus) 6480464 Omeprazole affects the expression of ACOT4 mRNA CTD PMID:19483382 Acot4 Mouse 6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime increases expression ISO ACOT4 (Homo sapiens) 6480464 6-(4-chlorophenyl)imidazo(2 more ... CTD PMID:30611723 Acot4 Mouse 6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime multiple interactions ISO ACOT4 (Homo sapiens) 6480464 [6-(4-chlorophenyl)imidazo(2 more ... CTD PMID:30611723 Acot4 Mouse 6-propyl-2-thiouracil affects expression ISO Acot4 (Rattus norvegicus) 6480464 Propylthiouracil affects the expression of ACOT4 mRNA CTD PMID:19483382 Acot4 Mouse 6-propyl-2-thiouracil increases expression ISO Acot4 (Rattus norvegicus) 6480464 Propylthiouracil results in increased expression of ACOT4 mRNA CTD PMID:24780913 Acot4 Mouse acetamide increases expression ISO Acot4 (Rattus norvegicus) 6480464 acetamide results in increased expression of ACOT4 mRNA CTD PMID:31881176 Acot4 Mouse Acetyl tributyl citrate increases expression EXP 6480464 2-acetyltributylcitrate results in increased expression of ACOT4 mRNA CTD PMID:37055963 Acot4 Mouse acrylamide decreases expression ISO Acot4 (Rattus norvegicus) 6480464 Acrylamide results in decreased expression of ACOT4 mRNA CTD PMID:28959563 Acot4 Mouse aflatoxin B1 affects expression ISO ACOT4 (Homo sapiens) 6480464 Aflatoxin B1 affects the expression of ACOT4 protein CTD PMID:20106945 Acot4 Mouse aflatoxin B1 decreases expression ISO Acot4 (Rattus norvegicus) 6480464 Aflatoxin B1 results in decreased expression of ACOT4 mRNA CTD PMID:33354967 Acot4 Mouse aflatoxin B1 decreases expression ISO ACOT4 (Homo sapiens) 6480464 Aflatoxin B1 results in decreased expression of ACOT4 mRNA CTD PMID:22100608 Acot4 Mouse amiodarone affects expression ISO Acot4 (Rattus norvegicus) 6480464 Amiodarone affects the expression of ACOT4 mRNA CTD PMID:19483382 Acot4 Mouse arsane affects methylation ISO ACOT4 (Homo sapiens) 6480464 Arsenic affects the methylation of ACOT4 gene CTD PMID:25304211 Acot4 Mouse arsenic atom affects methylation ISO ACOT4 (Homo sapiens) 6480464 Arsenic affects the methylation of ACOT4 gene CTD PMID:25304211 Acot4 Mouse arsenous acid increases expression ISO ACOT4 (Homo sapiens) 6480464 Arsenic Trioxide results in increased expression of ACOT4 mRNA CTD PMID:34108876 Acot4 Mouse azoxystrobin multiple interactions ISO Acot4 (Rattus norvegicus) 6480464 [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of ACOT4 mRNA CTD PMID:33854195 Acot4 Mouse benzbromarone affects expression ISO Acot4 (Rattus norvegicus) 6480464 Benzbromarone affects the expression of ACOT4 mRNA CTD PMID:19483382 Acot4 Mouse benzo[a]pyrene decreases expression ISO ACOT4 (Homo sapiens) 6480464 Benzo(a)pyrene results in decreased expression of ACOT4 mRNA CTD PMID:20106945 Acot4 Mouse benzo[a]pyrene decreases methylation ISO ACOT4 (Homo sapiens) 6480464 Benzo(a)pyrene results in decreased methylation of ACOT4 promoter CTD PMID:27901495 Acot4 Mouse benzo[a]pyrene increases expression EXP 6480464 Benzo(a)pyrene results in increased expression of ACOT4 mRNA CTD PMID:19770486 Acot4 Mouse bis(2-ethylhexyl) phthalate multiple interactions EXP 6480464 [Tetrachlorodibenzodioxin co-treated with 2 more ... CTD PMID:28433925 Acot4 Mouse bisphenol A decreases expression ISO Acot4 (Rattus norvegicus) 6480464 bisphenol A results in decreased expression of ACOT4 mRNA CTD PMID:25181051 more ... Acot4 Mouse bisphenol A multiple interactions ISO Acot4 (Rattus norvegicus) 6480464 [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of ACOT4 mRNA CTD PMID:36041667 Acot4 Mouse bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of ACOT4 mRNA CTD PMID:33221593 and PMID:34585602 Acot4 Mouse bisphenol A affects expression ISO Acot4 (Rattus norvegicus) 6480464 bisphenol A affects the expression of ACOT4 mRNA CTD PMID:30903817 Acot4 Mouse bisphenol A multiple interactions EXP 6480464 [Tetrachlorodibenzodioxin co-treated with 2 more ... CTD PMID:28433925 Acot4 Mouse bisphenol F multiple interactions ISO Acot4 (Rattus norvegicus) 6480464 [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of ACOT4 mRNA CTD PMID:36041667 Acot4 Mouse bromobenzene increases expression ISO Acot4 (Rattus norvegicus) 6480464 bromobenzene results in increased expression of ACOT4 mRNA CTD PMID:32479839 Acot4 Mouse butanal increases expression ISO ACOT4 (Homo sapiens) 6480464 butyraldehyde results in increased expression of ACOT4 mRNA CTD PMID:26079696 Acot4 Mouse carbon nanotube decreases expression EXP 6480464 Nanotubes and Carbon results in decreased expression of ACOT4 mRNA CTD PMID:25620056 Acot4 Mouse CGP 52608 multiple interactions ISO ACOT4 (Homo sapiens) 6480464 CGP 52608 promotes the reaction [RORA protein binds to ACOT4 gene] CTD PMID:28238834 Acot4 Mouse chlorpyrifos multiple interactions ISO Acot4 (Rattus norvegicus) 6480464 [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of ACOT4 mRNA CTD PMID:33854195 Acot4 Mouse ciprofibrate increases expression EXP 6480464 ciprofibrate results in increased expression of ACOT4 mRNA CTD PMID:27225895 Acot4 Mouse ciprofibrate increases expression ISO Acot4 (Rattus norvegicus) 6480464 ciprofibrate results in increased expression of ACOT4 mRNA CTD PMID:27225895 Acot4 Mouse clofibrate affects expression ISO Acot4 (Rattus norvegicus) 6480464 Clofibrate affects the expression of ACOT4 mRNA CTD PMID:19483382 Acot4 Mouse clofibrate increases expression EXP 6480464 Clofibrate results in increased expression of ACOT4 mRNA CTD PMID:23811191 more ... Acot4 Mouse clofibrate increases expression ISO Acot4 (Rattus norvegicus) 6480464 Clofibrate results in increased expression of ACOT4 mRNA CTD PMID:12851107 more ... Acot4 Mouse coumarin increases expression ISO Acot4 (Rattus norvegicus) 6480464 coumarin results in increased expression of ACOT4 mRNA CTD PMID:18480146 Acot4 Mouse coumestrol multiple interactions ISO ACOT4 (Homo sapiens) 6480464 [Coumestrol co-treated with 2 more ... CTD PMID:19167446 Acot4 Mouse coumestrol increases expression ISO ACOT4 (Homo sapiens) 6480464 Coumestrol results in increased expression of ACOT4 mRNA CTD PMID:19167446 Acot4 Mouse cyclosporin A decreases expression ISO ACOT4 (Homo sapiens) 6480464 Cyclosporine results in decreased expression of ACOT4 mRNA CTD PMID:20106945 Acot4 Mouse cyclosporin A increases expression ISO ACOT4 (Homo sapiens) 6480464 Cyclosporine results in increased expression of ACOT4 mRNA CTD PMID:27989131 Acot4 Mouse decabromodiphenyl ether increases expression ISO Acot4 (Rattus norvegicus) 6480464 decabromobiphenyl ether results in increased expression of ACOT4 mRNA CTD PMID:23640034 Acot4 Mouse diarsenic trioxide increases expression ISO ACOT4 (Homo sapiens) 6480464 Arsenic Trioxide results in increased expression of ACOT4 mRNA CTD PMID:34108876 Acot4 Mouse Dibutyl phosphate affects expression ISO ACOT4 (Homo sapiens) 6480464 di-n-butylphosphoric acid affects the expression of ACOT4 mRNA CTD PMID:37042841 Acot4 Mouse dichloroacetic acid increases expression EXP 6480464 Dichloroacetic Acid results in increased expression of ACOT4 mRNA CTD PMID:28962523 Acot4 Mouse endosulfan decreases expression ISO Acot4 (Rattus norvegicus) 6480464 Endosulfan results in decreased expression of ACOT4 mRNA CTD PMID:29391264 Acot4 Mouse Enterolactone multiple interactions ISO ACOT4 (Homo sapiens) 6480464 [Coumestrol co-treated with 2 and 3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of ACOT4 mRNA CTD PMID:19167446 Acot4 Mouse epoxiconazole affects expression EXP 6480464 epoxiconazole affects the expression of ACOT4 mRNA CTD PMID:35436446 Acot4 Mouse ethanol increases expression EXP 6480464 Ethanol results in increased expression of ACOT4 mRNA CTD PMID:19167417 Acot4 Mouse fenofibrate increases expression ISO Acot4 (Rattus norvegicus) 6480464 Fenofibrate results in increased expression of ACOT4 mRNA CTD PMID:27665778 and PMID:32741897 Acot4 Mouse fenthion increases expression EXP 6480464 Fenthion results in increased expression of ACOT4 mRNA CTD PMID:34813904 Acot4 Mouse furan increases methylation ISO Acot4 (Rattus norvegicus) 6480464 furan results in increased methylation of ACOT4 gene CTD PMID:22079235 Acot4 Mouse gemfibrozil increases expression ISO Acot4 (Rattus norvegicus) 6480464 Gemfibrozil results in increased expression of ACOT4 mRNA CTD PMID:27665778 Acot4 Mouse genistein increases expression EXP 6480464 Genistein results in increased expression of ACOT4 mRNA CTD PMID:32186404 Acot4 Mouse glafenine decreases expression ISO Acot4 (Rattus norvegicus) 6480464 Glafenine results in decreased expression of ACOT4 mRNA CTD PMID:24136188 Acot4 Mouse glutaryl-CoA affects hydrolysis EXP 6480464 ACOT4 protein affects the hydrolysis of glutaryl-coenzyme A CTD PMID:16141203 Acot4 Mouse glyphosate multiple interactions ISO Acot4 (Rattus norvegicus) 6480464 [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of ACOT4 mRNA CTD PMID:33854195 Acot4 Mouse GW 4064 increases expression EXP 6480464 GW 4064 results in increased expression of ACOT4 mRNA CTD PMID:26655953 Acot4 Mouse GW 4064 multiple interactions ISO ACOT4 (Homo sapiens) 6480464 [GW 4064 co-treated with Oleic Acid] results in decreased expression of ACOT4 mRNA CTD PMID:30611723 Acot4 Mouse GW 7647 increases expression ISO ACOT4 (Homo sapiens) 6480464 GW 7647 results in increased expression of ACOT4 mRNA CTD PMID:30611723 Acot4 Mouse GW 7647 multiple interactions ISO ACOT4 (Homo sapiens) 6480464 [GW 7647 co-treated with Oleic Acid] results in increased expression of ACOT4 mRNA CTD PMID:30611723 Acot4 Mouse imidacloprid multiple interactions ISO Acot4 (Rattus norvegicus) 6480464 [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of ACOT4 mRNA CTD PMID:33854195 Acot4 Mouse indole-3-methanol multiple interactions ISO Acot4 (Rattus norvegicus) 6480464 [indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of ACOT4 mRNA CTD PMID:22129741 Acot4 Mouse indometacin decreases expression ISO Acot4 (Rattus norvegicus) 6480464 Indomethacin results in decreased expression of ACOT4 mRNA CTD PMID:36868495 Acot4 Mouse L-ethionine affects expression ISO Acot4 (Rattus norvegicus) 6480464 Ethionine affects the expression of ACOT4 mRNA CTD PMID:19483382 Acot4 Mouse leflunomide increases expression ISO Acot4 (Rattus norvegicus) 6480464 leflunomide results in increased expression of ACOT4 mRNA CTD PMID:24136188 Acot4 Mouse methotrexate affects expression EXP 6480464 Methotrexate affects the expression of ACOT4 mRNA CTD PMID:18502557 Acot4 Mouse monosodium L-glutamate increases expression EXP 6480464 Sodium Glutamate results in increased expression of ACOT4 mRNA CTD PMID:20111022 Acot4 Mouse monosodium L-glutamate multiple interactions EXP 6480464 [Sodium Glutamate co-treated with High Fructose Corn Syrup] results in increased expression of ACOT4 mRNA CTD PMID:20111022 Acot4 Mouse N-nitrosodiethylamine multiple interactions ISO Acot4 (Rattus norvegicus) 6480464 [indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of ACOT4 mRNA CTD PMID:22129741 Acot4 Mouse nickel atom decreases expression ISO ACOT4 (Homo sapiens) 6480464 Nickel results in decreased expression of ACOT4 mRNA CTD PMID:25583101 Acot4 Mouse nickel sulfate decreases expression ISO ACOT4 (Homo sapiens) 6480464 nickel sulfate results in decreased expression of ACOT4 mRNA CTD PMID:22714537 Acot4 Mouse oleic acid multiple interactions ISO ACOT4 (Homo sapiens) 6480464 [6-(4-chlorophenyl)imidazo(2 more ... CTD PMID:30611723 Acot4 Mouse omeprazole affects expression ISO Acot4 (Rattus norvegicus) 6480464 Omeprazole affects the expression of ACOT4 mRNA CTD PMID:19483382 Acot4 Mouse paracetamol affects expression EXP 6480464 Acetaminophen affects the expression of ACOT4 mRNA CTD PMID:17562736 Acot4 Mouse paracetamol increases expression ISO Acot4 (Rattus norvegicus) 6480464 Acetaminophen results in increased expression of ACOT4 mRNA CTD PMID:32479839 Acot4 Mouse paracetamol decreases expression ISO ACOT4 (Homo sapiens) 6480464 Acetaminophen results in decreased expression of ACOT4 mRNA CTD PMID:26690555 and PMID:29067470 Acot4 Mouse parathion increases expression EXP 6480464 Parathion results in increased expression of ACOT4 mRNA CTD PMID:34813904 Acot4 Mouse PCB138 multiple interactions EXP 6480464 [2 more ... CTD PMID:25510870 Acot4 Mouse pentachlorophenol increases expression EXP 6480464 Pentachlorophenol results in increased expression of ACOT4 mRNA CTD PMID:23892564 Acot4 Mouse perfluorooctanoic acid increases expression EXP 6480464 perfluorooctanoic acid results in increased expression of ACOT4 mRNA CTD PMID:17681415 Acot4 Mouse perfluorooctanoic acid increases expression ISO Acot4 (Rattus norvegicus) 6480464 perfluorooctanoic acid results in increased expression of ACOT4 mRNA and perfluorooctanoic acid results in increased expression of ACOT4 protein CTD PMID:28511854 and PMID:34958885 Acot4 Mouse permethrin increases expression EXP 6480464 Permethrin results in increased expression of ACOT4 mRNA CTD PMID:30629241 Acot4 Mouse phenobarbital multiple interactions EXP 6480464 NR1I3 protein affects the reaction [Phenobarbital results in increased expression of ACOT4 mRNA] CTD PMID:19482888 Acot4 Mouse phenobarbital affects expression EXP 6480464 Phenobarbital affects the expression of ACOT4 mRNA CTD PMID:23091169 Acot4 Mouse phenobarbital increases expression EXP 6480464 Phenobarbital results in increased expression of ACOT4 mRNA CTD PMID:19482888 Acot4 Mouse pirinixic acid multiple interactions EXP 6480464 [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of ACOT4 mRNA more ... CTD PMID:16141203 and PMID:19710929 Acot4 Mouse pirinixic acid increases expression EXP 6480464 pirinixic acid results in increased expression of ACOT4 mRNA and pirinixic acid results in increased expression of ACOT4 protein CTD PMID:16141203 more ... Acot4 Mouse pirinixic acid increases expression ISO Acot4 (Rattus norvegicus) 6480464 pirinixic acid results in increased expression of ACOT4 mRNA CTD PMID:22484513 more ... Acot4 Mouse pirinixic acid affects expression ISO Acot4 (Rattus norvegicus) 6480464 pirinixic acid affects the expression of ACOT4 mRNA CTD PMID:19483382 Acot4 Mouse pravastatin decreases expression EXP 6480464 Pravastatin results in decreased expression of ACOT4 mRNA CTD PMID:27225895 Acot4 Mouse pregnenolone 16alpha-carbonitrile decreases expression EXP 6480464 Pregnenolone Carbonitrile results in decreased expression of ACOT4 mRNA CTD PMID:28903501 Acot4 Mouse propanal increases expression ISO ACOT4 (Homo sapiens) 6480464 propionaldehyde results in increased expression of ACOT4 mRNA CTD PMID:26079696 Acot4 Mouse resveratrol multiple interactions ISO ACOT4 (Homo sapiens) 6480464 [Coumestrol co-treated with resveratrol] results in increased expression of ACOT4 mRNA CTD PMID:19167446 Acot4 Mouse rotenone increases expression ISO Acot4 (Rattus norvegicus) 6480464 Rotenone results in increased expression of ACOT4 mRNA CTD PMID:28374803 Acot4 Mouse senecionine increases expression EXP 6480464 senecionine results in increased expression of ACOT4 protein CTD PMID:35357534 Acot4 Mouse succinyl-CoA affects hydrolysis EXP 6480464 ACOT4 protein affects the hydrolysis of succinyl-coenzyme A CTD PMID:16141203 Acot4 Mouse sulforaphane decreases expression ISO ACOT4 (Homo sapiens) 6480464 sulforaphane results in decreased expression of ACOT4 mRNA CTD PMID:31838189 Acot4 Mouse tetrachloroethene increases expression EXP 6480464 Tetrachloroethylene results in increased expression of ACOT4 mRNA CTD PMID:28973375 Acot4 Mouse thiabendazole multiple interactions ISO Acot4 (Rattus norvegicus) 6480464 [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of ACOT4 mRNA CTD PMID:33854195 Acot4 Mouse thioacetamide affects expression ISO Acot4 (Rattus norvegicus) 6480464 Thioacetamide affects the expression of ACOT4 mRNA CTD PMID:19483382 Acot4 Mouse thioacetamide decreases expression ISO Acot4 (Rattus norvegicus) 6480464 Thioacetamide results in decreased expression of ACOT4 mRNA CTD PMID:34492290 Acot4 Mouse thioacetamide increases expression ISO Acot4 (Rattus norvegicus) 6480464 Thioacetamide results in increased expression of ACOT4 mRNA CTD PMID:23411599 Acot4 Mouse trichloroethene increases expression EXP 6480464 Trichloroethylene results in increased expression of ACOT4 mRNA CTD PMID:25549359 Acot4 Mouse trichloroethene decreases expression ISO Acot4 (Rattus norvegicus) 6480464 Trichloroethylene results in decreased expression of ACOT4 mRNA CTD PMID:33387578 Acot4 Mouse triphenyl phosphate decreases expression ISO Acot4 (Rattus norvegicus) 6480464 triphenyl phosphate results in decreased expression of ACOT4 mRNA CTD PMID:30589522 Acot4 Mouse trovafloxacin decreases expression EXP 6480464 trovafloxacin results in decreased expression of ACOT4 mRNA CTD PMID:35537566 Acot4 Mouse valdecoxib increases expression ISO Acot4 (Rattus norvegicus) 6480464 valdecoxib results in increased expression of ACOT4 mRNA CTD PMID:24136188 Acot4 Mouse valproic acid affects expression EXP 6480464 Valproic Acid affects the expression of ACOT4 mRNA CTD PMID:17292431 and PMID:17963808 Acot4 Mouse vancomycin increases expression EXP 6480464 Vancomycin results in increased expression of ACOT4 mRNA CTD PMID:18930951 Acot4 Mouse zaragozic acid A increases expression ISO Acot4 (Rattus norvegicus) 6480464 squalestatin 1 results in increased expression of ACOT4 mRNA CTD PMID:27225895 Acot4 Mouse zaragozic acid A increases expression EXP 6480464 squalestatin 1 results in increased expression of ACOT4 mRNA CTD PMID:27225895