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Gene: Pou5f1 (POU domain, class 5, transcription factor 1) Mus musculus
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Symbol: Pou5f1
Name: POU domain, class 5, transcription factor 1
Description: Exhibits several functions, including DNA binding activity; DNA-binding transcription activator activity, RNA polymerase II-specific; and ubiquitin protein ligase binding activity. Involved in several processes, including blastocyst development; cell fate commitment involved in formation of primary germ layer; and regulation of protein kinase B signaling. Localizes to the cytoplasm; nucleus; and transcriptional repressor complex. Human ortholog(s) of this gene implicated in embryonal carcinoma and seminoma. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; gonad; and mesoderm. Orthologous to several human genes including POU5F1 (POU class 5 homeobox 1).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: NF-A3; Oct-3; Oct-3/4; Oct-4; Oct3; Oct3/4; Oct4; octamer-binding protein 3; octamer-binding protein 4; octamer-binding transcription factor 3; octamer-binding transcription factor 4 alternative; Otf-3; Otf-4; Otf3; Otf3-rs7; Otf3g; Otf4; POU domain class 5 transcription factor 1 transcript variant 2 oct4b'; POU domain class 5 transcription factor 1 transcript variant 3 oct4b
Orthologs:
Homo sapiens (human) : POU5F1 (POU class 5 homeobox 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Pou5f1 (POU class 5 homeobox 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pou5f1 (POU class 5 homeobox 1)
Pan paniscus (bonobo/pygmy chimpanzee) : POU5F1 (POU class 5 homeobox 1)
Canis lupus familiaris (dog) : POU5F1 (POU class 5 homeobox 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pou5f1 (POU class 5 homeobox 1)
Sus scrofa (pig) : POU5F1 (POU class 5 homeobox 1)
more info ...
Related Pseudogenes: Gm15049   Gm18893   Gm18926   Gm18931   Pou5f1-rs1   Pou5f1-rs2   Pou5f1-rs3   Pou5f1-rs4   Pou5f1-rs5   Pou5f1-rs6   Pou5f1-rs8   Pou5f1-rs9  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm381735,506,032 - 35,510,777 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371735,642,984 - 35,647,722 (+)NCBIGRCm37mm9NCBIm37
MGSCv361735,114,104 - 35,118,822 (+)NCBImm8
Celera1739,020,977 - 39,025,724 (+)NCBICelera
Cytogenetic Map17 B1NCBI
cM Map1718.69NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Pou5f1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1552733
Created: 2005-09-30
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.