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Gene: Pou5f1 (POU domain, class 5, transcription factor 1) Mus musculus
Symbol: Pou5f1
Name: POU domain, class 5, transcription factor 1
Description: Exhibits several functions, including DNA binding activity; DNA-binding transcription activator activity, RNA polymerase II-specific; and ubiquitin protein ligase binding activity. Involved in several processes, including blastocyst development; cell fate commitment involved in formation of primary germ layer; and regulation of protein kinase B signaling. Localizes to the cytoplasm; nucleus; and transcriptional repressor complex. Human ortholog(s) of this gene implicated in embryonal carcinoma and seminoma. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; gonad; and mesoderm. Orthologous to several human genes including POU5F1 (POU class 5 homeobox 1).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: NF-A3; Oct-3; Oct-3/4; Oct-4; Oct3; Oct3/4; Oct4; octamer-binding protein 3; octamer-binding protein 4; octamer-binding transcription factor 3; octamer-binding transcription factor 4 alternative; Otf-3; Otf-4; Otf3; Otf3-rs7; Otf3g; Otf4; POU domain class 5 transcription factor 1 transcript variant 2 oct4b'; POU domain class 5 transcription factor 1 transcript variant 3 oct4b
Homo sapiens (human) : POU5F1 (POU class 5 homeobox 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Pou5f1 (POU class 5 homeobox 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pou5f1 (POU class 5 homeobox 1)
Pan paniscus (bonobo/pygmy chimpanzee) : POU5F1 (POU class 5 homeobox 1)
Canis lupus familiaris (dog) : POU5F1 (POU class 5 homeobox 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pou5f1 (POU class 5 homeobox 1)
Sus scrofa (pig) : POU5F1 (POU class 5 homeobox 1)
more info ...
Related Pseudogenes: Gm15049   Gm18893   Gm18926   Gm18931   Pou5f1-rs1   Pou5f1-rs2   Pou5f1-rs3   Pou5f1-rs4   Pou5f1-rs5   Pou5f1-rs6   Pou5f1-rs8   Pou5f1-rs9  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm381735,506,032 - 35,510,777 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371735,642,984 - 35,647,722 (+)NCBIGRCm37mm9NCBIm37
MGSCv361735,114,104 - 35,118,822 (+)NCBImm8
Celera1739,020,977 - 39,025,724 (+)NCBICelera
Cytogenetic Map17 B1NCBI
cM Map1718.69NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Pou5f1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1552733
Created: 2005-09-30
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.