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Gene: Aldh2 (aldehyde dehydrogenase 2, mitochondrial) Mus musculus
Symbol: Aldh2
Name: aldehyde dehydrogenase 2, mitochondrial
RGD ID: 69218
Description: Predicted to have NADH binding activity; aldehyde dehydrogenase (NAD+) activity; and identical protein binding activity. Predicted to be involved in several processes, including behavioral response to ethanol; cellular detoxification of aldehyde; and intrinsic apoptotic signaling pathway in response to oxidative stress. Localizes to mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; artery disease (multiple); diabetes mellitus (multiple); diabetic neuropathy; and liver disease (multiple). Orthologous to human ALDH2 (aldehyde dehydrogenase 2 family member); PARTICIPATES IN 3-hydroxy-3-methylglutaryl-CoA lyase deficiency pathway; 3-hydroxyisobutyric aciduria pathway; 3-methylcrotonyl CoA carboxylase 1 deficiency pathway; INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrabromodibenzodioxine; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Ahd; Ahd-; Ahd-5; AHD-M1; Ahd5; aldehyde dehydrogenase, mitochondrial; ALDH class 2; ALDH-E2; ALDHI
Homo sapiens (human) : ALDH2 (aldehyde dehydrogenase 2 family member)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Aldh2 (aldehyde dehydrogenase 2 family member)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Aldh2 (aldehyde dehydrogenase 2 family member)
Pan paniscus (bonobo/pygmy chimpanzee) : ALDH2 (aldehyde dehydrogenase 2 family member)
Canis lupus familiaris (dog) : ALDH2 (aldehyde dehydrogenase 2 family member)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Aldh2 (aldehyde dehydrogenase 2 family member)
Sus scrofa (pig) : ALDH2 (aldehyde dehydrogenase 2 family member)
Chlorocebus sabaeus (African green monkey) : ALDH2 (aldehyde dehydrogenase 2 family member)
Heterocephalus glaber (naked mole-rat) : Aldh2 (aldehyde dehydrogenase 2 family member)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm395121,704,090 - 121,731,887 (-)NCBI
GRCm385121,566,027 - 121,593,824 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5121,566,027 - 121,593,824 (-)EnsemblGRCm38mm10GRCm38
MGSCv375122,017,696 - 122,043,833 (-)NCBIGRCm37mm9NCBIm37
MGSCv365121,828,319 - 121,854,203 (-)NCBImm8
Celera5118,657,638 - 118,683,765 (-)NCBICelera
Cytogenetic Map5FNCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Aldh2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 69218
Created: 2001-11-13
Species: Mus musculus
Last Modified: 2020-10-13
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.