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Gene: Aldh2 (aldehyde dehydrogenase 2, mitochondrial) Mus musculus
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Symbol: Aldh2
Name: aldehyde dehydrogenase 2, mitochondrial
Description: Predicted to have NADH binding activity; aldehyde dehydrogenase (NAD+) activity; and identical protein binding activity. Predicted to be involved in negative regulation of apoptotic process. Localizes to the mitochondrion. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; artery disease (multiple); diabetes mellitus (multiple); diabetic neuropathy; and liver disease (multiple). Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human ALDH2 (aldehyde dehydrogenase 2 family member); PARTICIPATES IN 3-hydroxy-3-methylglutaryl-CoA lyase deficiency pathway; 3-hydroxyisobutyric aciduria pathway; 3-methylcrotonyl CoA carboxylase 1 deficiency pathway; INTERACTS WITH 2,3,7,8-tetrabromodibenzodioxine; 2,3,7,8-tetrachlorodibenzodioxine; 2-ethoxyethanol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Ahd-5; AHD-M1; Ahd5; aldehyde dehydrogenase, mitochondrial; ALDH class 2; ALDH-E2; ALDHI
Orthologs:
Homo sapiens (human) : ALDH2 (aldehyde dehydrogenase 2 family member)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Aldh2 (aldehyde dehydrogenase 2 family member)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Aldh2 (aldehyde dehydrogenase 2 family member)
Pan paniscus (bonobo/pygmy chimpanzee) : ALDH2 (aldehyde dehydrogenase 2 family member)
Canis lupus familiaris (dog) : ALDH2 (aldehyde dehydrogenase 2 family member)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Aldh2 (aldehyde dehydrogenase 2 family member)
Sus scrofa (pig) : ALDH2 (aldehyde dehydrogenase 2 family member)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm385121,566,027 - 121,593,824 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv375122,017,696 - 122,043,833 (-)NCBIGRCm37mm9NCBIm37
MGSCv365121,828,319 - 121,854,203 (-)NCBImm8
Celera5118,657,638 - 118,683,765 (-)NCBICelera
Cytogenetic Map5 FNCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Aldh2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 69218
Created: 2001-11-13
Species: Mus musculus
Last Modified: 2019-11-13
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.