Aldh2 (aldehyde dehydrogenase 2, mitochondrial) - Rat Genome Database

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Gene: Aldh2 (aldehyde dehydrogenase 2, mitochondrial) Mus musculus
Analyze
Symbol: Aldh2
Name: aldehyde dehydrogenase 2, mitochondrial
RGD ID: 69218
MGI Page MGI
Description: Predicted to enable several functions, including NADH binding activity; carboxylesterase activity; and nitroglycerin reductase activity. Involved in regulation of dopamine biosynthetic process and regulation of serotonin biosynthetic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; alcohol use disorder; artery disease (multiple); diabetes mellitus (multiple); and liver disease (multiple). Orthologous to human ALDH2 (aldehyde dehydrogenase 2 family member).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Ahd; Ahd-; Ahd-5; AHD-M1; Ahd5; aldehyde dehydrogenase, mitochondrial; ALDH class 2; ALDH-E2; ALDHI
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395121,704,090 - 121,731,887 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5121,704,090 - 121,731,887 (-)EnsemblGRCm39 Ensembl
GRCm385121,566,027 - 121,593,824 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5121,566,027 - 121,593,824 (-)EnsemblGRCm38mm10GRCm38
MGSCv375122,017,696 - 122,043,833 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365121,828,319 - 121,854,203 (-)NCBIMGSCv36mm8
Celera5118,657,638 - 118,683,765 (-)NCBICelera
Cytogenetic Map5FNCBI
cM Map561.86NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (EXP)
1,2-dimethylhydrazine  (EXP)
1,3,5-trimethylbenzene  (ISO)
1,3-dinitrobenzene  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrabromodibenzodioxine  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2,5-dihydroxybenzaldehyde  (ISO)
2-ethoxyethanol  (EXP)
2-hydroxypropanoic acid  (ISO)
3',5'-cyclic GMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-dihydroxyphenylacetaldehyde  (ISO)
3,4-methylenedioxymethamphetamine  (EXP,ISO)
3-hydroxybenzaldehyde  (ISO)
3-hydroxypyruvic acid  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-(diethylamino)benzaldehyde  (ISO)
4-dimethylaminocinnamaldehyde  (ISO)
4-hydroperoxycyclophosphamide  (ISO)
4-hydroxynon-2-enal  (EXP,ISO)
4-nitrophenyl acetate  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-propyl-2-thiouracil  (ISO)
acetaldehyde  (EXP,ISO)
acetamide  (ISO)
acetophenone  (ISO)
acrolein  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinal  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
ammonium chloride  (ISO)
aniline  (ISO)
antimycin A  (ISO)
aristolochic acid A  (ISO)
atrazine  (ISO)
azoxystrobin  (ISO)
benomyl  (EXP,ISO)
benzaldehyde  (ISO)
benzaldehydes  (ISO)
benzbromarone  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzyl isothiocyanate  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bromobenzene  (ISO)
butanal  (ISO)
butane-2,3-diol  (ISO)
cadmium atom  (EXP)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
captan  (EXP)
carbamazepine  (ISO)
carbon nanotube  (EXP)
celecoxib  (ISO)
CGP 52608  (ISO)
chloral hydrate  (ISO)
chloroacetaldehyde  (ISO)
chloroethene  (ISO)
chloroprene  (EXP)
chlorpyrifos  (ISO)
choline  (EXP,ISO)
cisplatin  (ISO)
clofibrate  (EXP,ISO)
cocaine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
Cuprizon  (ISO)
cyanamide  (ISO)
cyanocob(III)alamin  (EXP)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
D-glucose  (ISO)
D-glyceraldehyde  (ISO)
daidzein 7-O-beta-D-glucoside  (ISO)
decanal  (ISO)
dexamethasone  (EXP)
dextran sulfate  (EXP)
Di-n-hexyl phthalate  (ISO)
diallyl disulfide  (EXP)
diazinon  (ISO)
dibutyl phthalate  (ISO)
Dicyclohexyl phthalate  (ISO)
diethyl maleate  (EXP,ISO)
diethylstilbestrol  (EXP)
diisobutyl phthalate  (ISO)
dimethoate  (ISO)
dimethylarsinous acid  (ISO)
disulfiram  (EXP,ISO)
diuron  (ISO)
dopamine  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
enilconazole  (ISO)
epoxiconazole  (EXP)
EPTC  (EXP)
ethanol  (EXP,ISO)
flavonoids  (ISO)
flutamide  (ISO)
folic acid  (EXP,ISO)
folpet  (EXP)
formaldehyde  (ISO)
furan  (ISO)
gentamycin  (ISO)
glafenine  (ISO)
glucose  (ISO)
glyceraldehyde  (ISO)
glycine betaine  (EXP)
glycolaldehyde  (ISO)
glyoxal  (ISO)
GW 4064  (EXP)
hemin  (ISO)
hexanal  (ISO)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (ISO)
indometacin  (ISO)
iprodione  (ISO)
isoprenaline  (EXP)
ivermectin  (ISO)
L-ascorbic acid  (EXP)
L-ethionine  (ISO)
L-methionine  (EXP,ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
m-xylene  (ISO)
magnesium atom  (ISO)
malonaldehyde  (ISO)
mancozeb  (ISO)
maneb  (ISO)
menadione  (ISO)
menthofuran  (ISO)
methamphetamine  (ISO)
methapyrilene  (ISO)
methylglyoxal  (ISO)
mitoxantrone  (ISO)
molinate  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
N,N-diethyl-m-toluamide  (ISO)
N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide  (ISO)
N-acetyl-L-cysteine  (ISO)
N-nitrosomorpholine  (ISO)
N-tosyl-L-phenylalanyl chloromethyl ketone  (ISO)
NAD zwitterion  (EXP,ISO)
NAD(+)  (EXP,ISO)
NADP zwitterion  (EXP)
NADP(+)  (EXP)
naphthalene  (EXP)
nitric oxide  (EXP)
nitroglycerin  (EXP,ISO)
norlaudanosoline  (ISO)
omeprazole  (ISO)
Oxadiazon  (ISO)
ozone  (EXP)
paracetamol  (EXP,ISO)
paraquat  (ISO)
pentaerythritol tetranitrate  (EXP,ISO)
pentrinitrol  (EXP)
perfluorododecanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (ISO)
permethrin  (ISO)
phenacyl bromide  (ISO)
phenobarbital  (EXP)
PhIP  (ISO)
phlorizin  (EXP)
phosphorothioate oligonucleotide  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (EXP,ISO)
propanal  (ISO)
propiconazole  (EXP)
prunetin  (ISO)
pyrimidifen  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (EXP,ISO)
rac-lactic acid  (ISO)
reactive oxygen species  (ISO)
resveratrol  (EXP,ISO)
rotenone  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (EXP)
silver(0)  (EXP)
sodium arsenate  (EXP)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
sodium fluoride  (EXP)
streptozocin  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tacrolimus hydrate  (EXP)
taraxerone  (EXP)
tert-butyl ethyl ether  (EXP)
tert-butyl hydroperoxide  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
trichostatin A  (ISO)
troglitazone  (EXP)
ubiquinones  (EXP)
valproic acid  (EXP,ISO)
vancomycin  (EXP)
vinclozolin  (ISO)
vorinostat  (ISO)
zinc atom  (EXP)
zinc sulfate  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
3-hydroxy-3-methylglutaryl-CoA lyase deficiency pathway  (ISO)
3-hydroxyisobutyric aciduria pathway  (ISO)
3-methylcrotonyl CoA carboxylase 1 deficiency pathway  (ISO)
3-methylglutaconic aciduria type 1 pathway  (ISO)
3-methylglutaconic aciduria type 3 pathway  (ISO)
arginine and proline metabolic pathway  (IEA)
ascorbate and aldarate metabolic pathway  (IEA)
beta-alanine metabolic pathway  (IEA,ISO)
carnosinemia pathway  (ISO)
dihydropyrimidine dehydrogenase deficiency pathway  (ISO)
dimethylglycine dehydrogenase deficiency pathway  (ISO)
disulfiram pharmacodynamics pathway  (ISO)
GABA aminotransferase deficiency pathway   (ISO)
gluconeogenesis pathway   (IEA)
glycolysis pathway  (IEA)
glycolysis/gluconeogenesis pathway  (IEA)
histidine metabolic pathway  (IEA,ISO)
histidinemia pathway  (ISO)
isobutyryl-CoA dehydrogenase deficiency pathway  (ISO)
isovaleric acidemia pathway  (ISO)
Leigh disease pathway  (ISO)
lysine degradation pathway  (IEA)
maple syrup urine disease pathway  (ISO)
methylmalonate semialdehyde dehydrogenase deficiency pathway  (ISO)
methylmalonic acidemia pathway  (ISO)
nonketotic hyperglycinemia pathway  (ISO)
pentose and glucuronate interconversion pathway  (IEA)
primary hyperoxaluria type 2 pathway  (ISO)
propanoate metabolic pathway  (IEA)
propionic acidemia pathway  (ISO)
pyruvate decarboxylase deficiency pathway  (ISO)
pyruvate dehydrogenase E1 deficiency pathway  (ISO)
pyruvate kinase deficiency of red cells pathway   (ISO)
pyruvate metabolic pathway  (IEA,ISO)
sarcosinemia pathway  (ISO)
tryptophan metabolic pathway  (IEA,ISO)
valine, leucine and isoleucine degradation pathway  (IEA,ISO)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal bone marrow cell morphology/development  (IAGP)
abnormal bone mineralization  (IEA)
abnormal cardiac output  (IAGP)
abnormal cellular respiration  (IAGP)
abnormal chest morphology  (IAGP)
abnormal circulating hormone level  (IAGP)
abnormal enzyme/coenzyme activity  (IAGP)
abnormal ethanol metabolism  (IAGP)
abnormal eye morphology  (IAGP)
abnormal heart rate  (IAGP)
abnormal hematopoietic stem cell physiology  (IAGP)
abnormal hippocampus morphology  (IAGP)
abnormal lens morphology  (IEA)
abnormal lymphopoiesis  (IAGP)
abnormal nociception after inflammation  (IAGP)
abnormal response to novel object  (IAGP)
abnormal response to tactile stimuli  (IEA)
abnormal spatial working memory  (IAGP)
abnormal spleen morphology  (IAGP)
abnormal startle reflex  (IEA)
abnormal thymus morphology  (IAGP)
abnormal urination  (IEA)
anemia  (IAGP)
anophthalmia  (IAGP)
cardiac hypertrophy  (IAGP)
congestive heart failure  (IAGP)
decreased alcohol consumption  (IAGP)
decreased body weight  (IAGP)
decreased bone marrow cell number  (IAGP)
decreased bone mineral density  (IEA)
decreased cardiac muscle contractility  (IAGP)
decreased CD4-positive, alpha-beta T cell number  (IEA)
decreased CD8-positive, alpha-beta T cell number  (IEA)
decreased circulating alkaline phosphatase level  (IEA)
decreased circulating cholesterol level  (IEA)
decreased circulating HDL cholesterol level  (IEA)
decreased circulating LDL cholesterol level  (IEA)
decreased circulating total protein level  (IEA)
decreased erythrocyte cell number  (IAGP)
decreased hematocrit  (IAGP)
decreased hematopoietic stem cell number  (IAGP)
decreased hemoglobin content  (IAGP)
decreased leukocyte cell number  (IAGP)
decreased litter size  (IAGP)
decreased T cell number  (IEA)
decreased tumor latency  (IAGP)
embryonic lethality during organogenesis  (IAGP)
enhanced behavioral response to alcohol  (IAGP)
enlarged spleen  (IAGP)
exencephaly  (IAGP)
extramedullary hematopoiesis  (IAGP)
hyperalgesia  (IAGP)
hyperpigmentation  (IAGP)
impaired exercise endurance  (IAGP)
impaired hematopoiesis  (IAGP)
increased acute lymphoblastic leukemia incidence  (IAGP)
increased CD8-positive, alpha-beta T cell number  (IAGP)
increased circulating free fatty acids level  (IEA)
increased double-positive T cell number  (IAGP)
increased hepatocyte apoptosis  (IAGP)
increased incidence of tumors by chemical induction  (IAGP)
increased lymphoma incidence  (IAGP)
increased mean corpuscular volume  (IAGP)
increased physiological sensitivity to xenobiotic  (IAGP)
increased sensitivity to induced cell death  (IAGP)
increased susceptibility to induced morbidity/mortality  (IAGP)
increased susceptibility to xenobiotic induced morbidity/mortality  (IAGP)
increased T cell derived lymphoma incidence  (IAGP)
kinked tail  (IAGP)
lethargy  (IAGP)
maternal effect  (IAGP)
pancytopenia  (IAGP)
premature death  (IAGP)
thrombocytopenia  (IAGP)
weight loss  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Aldehyde dehydrogenase 2 polymorphism for development to hepatocellular carcinoma in East Asian alcoholic liver cirrhosis. Abe H, etal., J Gastroenterol Hepatol. 2015 Sep;30(9):1376-83. doi: 10.1111/jgh.12948.
2. Epidemiologic study of the association of low-Km mitochondrial acetaldehyde dehydrogenase genotypes with blood pressure level and the prevalence of hypertension in a general population. Amamoto K, etal., Hypertens Res. 2002 Nov;25(6):857-64.
3. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
4. Association Between Aldehyde Dehydrogenase 2 Glu504Lys Polymorphism and Alcoholic Liver Disease. Chang B, etal., Am J Med Sci. 2018 Jul;356(1):10-14. doi: 10.1016/j.amjms.2018.03.012. Epub 2018 Mar 20.
5. Chinese alcoholic patients with esophageal cancer are genetically different from alcoholics with acute pancreatitis and liver cirrhosis. Chao YC, etal., Am J Gastroenterol. 2000 Oct;95(10):2958-64. doi: 10.1111/j.1572-0241.2000.02328.x.
6. ALDH2 Deficiency Promotes Ethanol-Induced Gut Barrier Dysfunction and Fatty Liver in Mice. Chaudhry KK, etal., Alcohol Clin Exp Res. 2015 Aug;39(8):1465-75. doi: 10.1111/acer.12777. Epub 2015 Jul 14.
7. Activation of aldehyde dehydrogenase-2 reduces ischemic damage to the heart. Chen CH, etal., Science. 2008 Sep 12;321(5895):1493-5. doi: 10.1126/science.1158554.
8. Proteomic alteration of mitochondrial aldehyde dehydrogenase 2 in sepsis regulated by heat shock response. Chen HW, etal., Shock. 2007 Dec;28(6):710-6. doi: 10.1097/shk.0b013e318050c8c2.
9. Vinyl chloride-induced interaction of nonalcoholic and toxicant-associated steatohepatitis: Protection by the ALDH2 activator Alda-1. Chen L, etal., Redox Biol. 2019 Jun;24:101205. doi: 10.1016/j.redox.2019.101205. Epub 2019 Apr 19.
10. Alcohol dehydrogenase-2 and aldehyde dehydrogenase-2 genotypes, alcohol drinking and the risk of primary hepatocellular carcinoma in a Chinese population. Ding J, etal., Asian Pac J Cancer Prev. 2008 Jan-Mar;9(1):31-5.
11. Genotyping of the aldehyde dehydrogenase 2 (ALDH2) gene using the polymerase chain reaction: evidence for single point mutation in the ALDH2 gene of ALDH2-deficiency. Enomoto N, etal., Gastroenterol Jpn. 1991 Aug;26(4):440-7.
12. Alcohol inhibits T-cell glucose metabolism and hepatitis in ALDH2-deficient mice and humans: roles of acetaldehyde and glucocorticoids. Gao Y, etal., Gut. 2019 Jul;68(7):1311-1322. doi: 10.1136/gutjnl-2018-316221. Epub 2018 Aug 18.
13. Eliciting the low-activity aldehyde dehydrogenase Asian phenotype by an antisense mechanism results in an aversion to ethanol. Garver E, etal., J Exp Med. 2001 Sep 3;194(5):571-80. doi: 10.1084/jem.194.5.571.
14. Aldehyde dedydrogenase-2 plays a beneficial role in ameliorating chronic alcohol-induced hepatic steatosis and inflammation through regulation of autophagy. Guo R, etal., J Hepatol. 2015 Mar;62(3):647-56. doi: 10.1016/j.jhep.2014.10.009. Epub 2014 Oct 20.
15. Mitochondria-targeted ubiquinone (MitoQ) enhances acetaldehyde clearance by reversing alcohol-induced posttranslational modification of aldehyde dehydrogenase 2: A molecular mechanism of protection against alcoholic liver disease. Hao L, etal., Redox Biol. 2018 Apr;14:626-636. doi: 10.1016/j.redox.2017.11.005. Epub 2017 Nov 11.
16. Aldehyde dehydrogenase-2 (ALDH2) opposes hepatocellular carcinoma progression by regulating AMP-activated protein kinase signaling in mice. Hou G, etal., Hepatology. 2017 May;65(5):1628-1644. doi: 10.1002/hep.29006. Epub 2017 Mar 31.
17. Genes associated with immunoglobulin V(D)J recombination are linked on mouse chromosome 2 and human chromosome 11. Huppi K, etal., Immunogenetics 1993;37(4):288-91.
18. Change of components of the metabolic syndrome in a workers' health checkup after five years--relation with elevated liver enzymes, gene polymorphisms for ALDH 2, beta3-AR and lifestyle. Ishikawa N, etal., Nippon Koshu Eisei Zasshi. 2005 Nov;52(11):979-86.
19. ALDH2(E487K) mutation increases protein turnover and promotes murine hepatocarcinogenesis. Jin S, etal., Proc Natl Acad Sci U S A. 2015 Jul 21;112(29):9088-93. doi: 10.1073/pnas.1510757112. Epub 2015 Jul 6.
20. Impact of alcohol consumption with polymorphisms in alcohol-metabolizing enzymes on pancreatic cancer risk in Japanese. Kanda J, etal., Cancer Sci. 2008 Dec 4.
21. Genetic polymorphisms of aldehyde dehydrogenase 2, cytochrome p450 2E1 for liver cancer risk in HCV antibody-positive japanese patients and the variations of CYP2E1 mRNA expression levels in the liver due to its polymorphism. Kato S, etal., Scand J Gastroenterol. 2003 Aug;38(8):886-93.
22. Gender differences in the genetic risk for alcohol dependence--the results of a pharmacogenetic study in Korean alcoholics. Kim SG, Nihon Arukoru Yakubutsu Igakkai Zasshi. 2009 Dec;44(6):680-5.
23. Aldehyde dehydrogenase 2 deficiency ameliorates alcoholic fatty liver but worsens liver inflammation and fibrosis in mice. Kwon HJ, etal., Hepatology. 2014 Jul;60(1):146-57. doi: 10.1002/hep.27036. Epub 2014 May 28.
24. Isoflurane Preconditioning Confers Cardioprotection by Activation of ALDH2. Lang XE, etal., PLoS One. 2013;8(2):e52469. doi: 10.1371/journal.pone.0052469. Epub 2013 Feb 28.
25. Alda-1 Ameliorates Liver Ischemia-Reperfusion Injury by Activating Aldehyde Dehydrogenase 2 and Enhancing Autophagy in Mice. Li M, etal., J Immunol Res. 2018 Dec 24;2018:9807139. doi: 10.1155/2018/9807139. eCollection 2018.
26. [Activation of mitochondrial aldehyde dehydrogenase 2 and inhibition of mitochondrial permeability transition pore involved in cardioprotection of ethanol postconditioning]. Li ZH, etal., Zhejiang Da Xue Xue Bao Yi Xue Ban. 2010 Nov;39(6):566-71.
27. Alcohol Drinking Mediates the Association between Polymorphisms of ADH1B and ALDH2 and Hepatitis B-Related Hepatocellular Carcinoma. Liu J, etal., Cancer Epidemiol Biomarkers Prev. 2016 Apr;25(4):693-9. doi: 10.1158/1055-9965.EPI-15-0961. Epub 2016 Jan 31.
28. Resveratrol attenuates excessive ethanol exposure induced insulin resistance in rats via improving NAD+ /NADH ratio. Luo G, etal., Mol Nutr Food Res. 2017 Nov;61(11). doi: 10.1002/mnfr.201700087. Epub 2017 Aug 15.
29. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
30. MGDs mouse GO annotations MGD data from the GO Consortium
31. MGD IEA MGD IEA
32. Inactive aldehyde dehydrogenase-2 increased the risk of pancreatic cancer among smokers in a Japanese male population. Miyasaka K, etal., Pancreas. 2005 Mar;30(2):95-8.
33. Inactivation of oxidized and S-nitrosylated mitochondrial proteins in alcoholic fatty liver of rats. Moon KH, etal., Hepatology. 2006 Nov;44(5):1218-30.
34. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, etal., Cell 2003 Nov 26;115(5):629-40.
35. Meta-analysis of three diabetes population studies: association of inactive ALDH2 genotype with maternal inheritance of diabetes. Murata C, etal., Diabetes Res Clin Pract. 2004 Dec;66 Suppl 1:S145-7.
36. A polymorphism of the aldehyde dehydrogenase 2 gene is a risk factor for multiple lacunar infarcts in Japanese men: the Takahata Study. Nagasawa H, etal., Eur J Neurol. 2007 Apr;14(4):428-34.
37. Assessment of a difference in ALDH2 heterozygotes and alcoholic liver injury. Nagata N, etal., Alcohol Clin Exp Res. 2002 Aug;26(8 Suppl):11S-14S. doi: 10.1097/01.ALC.0000027923.82434.7F.
38. Association of mu-opioid receptor gene polymorphism A118G with alcohol dependence in a Japanese population. Nishizawa D, etal., Neuropsychobiology. 2006;53(3):137-41. doi: 10.1159/000093099. Epub 2006 May 4.
39. Mitochondrial ALDH2 deficiency as an oxidative stress. Ohta S, etal., Ann N Y Acad Sci. 2004 Apr;1011:36-44.
40. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
41. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
42. The longitudinal effect of the aldehyde dehydrogenase 2*2 allele on the risk for nonalcoholic fatty liver disease. Oniki K, etal., Nutr Diabetes. 2016 May 23;6:e210. doi: 10.1038/nutd.2016.17.
43. Aldehyde Dehydrogenase 2 (ALDH2) in Rat Fatty Liver Cold Ischemia Injury. Panisello-Roselló A, etal., Int J Mol Sci. 2018 Aug 22;19(9). pii: ijms19092479. doi: 10.3390/ijms19092479.
44. Involvement of acetaldehyde for full protection against alcoholism by homozygosity of the variant allele of mitochondrial aldehyde dehydrogenase gene in Asians. Peng GS, etal., Pharmacogenetics 1999 Aug;9(4):463-76.
45. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
46. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
47. Mouse MP Annotation Import Pipeline RGD automated import pipeline
48. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
49. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
50. Genotypes of alcohol-metabolizing enzymes in Japanese with alcohol liver diseases: a strong association of the usual Caucasian-type aldehyde dehydrogenase gene (ALDH1(2)) with the disease. Shibuya A and Yoshida A, Am J Hum Genet. 1988 Nov;43(5):744-8.
51. Mitochondrial aldehyde dehydrogenase activation by Alda-1 inhibits atherosclerosis and attenuates hepatic steatosis in apolipoprotein E-knockout mice. Stachowicz A, etal., J Am Heart Assoc. 2014 Nov 12;3(6):e001329. doi: 10.1161/JAHA.114.001329.
52. ALDH2/ADH2 polymorphism associated with vasculopathy and neuropathy in type 2 diabetes. Suzuki Y, etal., Alcohol Clin Exp Res. 2004 Aug;28(8 Suppl Proceedings):111S-116S.
53. Aldehyde dehydrogenase 2 genotype in type 1 diabetes mellitus. Suzuki Y, etal., Diabetes Res Clin Pract. 2003 May;60(2):139-41.
54. The aldehyde dehydrogenase 2 gene is a risk factor for hypertension in Japanese but does not alter the sensitivity to pressor effects of alcohol: the Suita study. Takagi S, etal., Hypertens Res. 2001 Jul;24(4):365-70.
55. Aldehyde dehydrogenase 2 gene is a risk factor for myocardial infarction in Japanese men. Takagi S, etal., Hypertens Res. 2002 Sep;25(5):677-81.
56. Relationship between alcohol drinking, ADH2 and ALDH2 genotypes, and risk for hepatocellular carcinoma in Japanese. Takeshita T, etal., Cancer Lett. 2000 Feb 28;149(1-2):69-76. doi: 10.1016/s0304-3835(99)00343-2.
57. Effects of the Nonsteroidal Anti-inflammatory Drug Celecoxib on Mitochondrial Function. Tatematsu Y, etal., Biol Pharm Bull. 2018;41(3):319-325. doi: 10.1248/bpb.b17-00527.
58. Inhibition of aldehyde dehydrogenase 2 by oxidative stress is associated with cardiac dysfunction in diabetic rats. Wang J, etal., Mol Med. 2011 Mar-Apr;17(3-4):172-9. doi: 10.2119/molmed.2010.00114. Epub 2010 Oct 15.
59. The aldehyde dehydrogenase 2 gene is associated with heroin dependence. Wang TY, etal., Drug Alcohol Depend. 2012 Jan 1;120(1-3):220-4. doi: 10.1016/j.drugalcdep.2011.06.008. Epub 2011 Jul 1.
60. Cloning of a cDNA encoding an aldehyde dehydrogenase and its expression in Escherichia coli. Recognition of retinal as substrate. Wang X, etal., J Biol Chem 1996 Jul 5;271(27):16288-93.
61. Identification of liver proteins and their roles associated with carbon tetrachloride-induced hepatotoxicity. Wong LL, etal., Hum Exp Toxicol. 2011 Sep;30(9):1369-81. doi: 10.1177/0960327110391388. Epub 2010 Dec 7.
62. Genetic variants of ALDH2-rs671 and CYP2E1-rs2031920 contributed to risk of hepatocellular carcinoma susceptibility in a Chinese population. Ye X, etal., Cancer Manag Res. 2018 May 4;10:1037-1050. doi: 10.2147/CMAR.S162105. eCollection 2018.
63. Genetic polymorphisms of alcohol dehydrogenase-1B and aldehyde dehydrogenase-2 and liver cirrhosis, chronic calcific pancreatitis, diabetes mellitus, and hypertension among Japanese alcoholic men. Yokoyama A, etal., Alcohol Clin Exp Res. 2013 Aug;37(8):1391-401. doi: 10.1111/acer.12108. Epub 2013 Mar 29.
64. Slow-metabolizing ADH1B and inactive heterozygous ALDH2 increase vulnerability to fatty liver in Japanese men with alcohol dependence. Yokoyama A, etal., J Gastroenterol. 2018 May;53(5):660-669. doi: 10.1007/s00535-017-1402-6. Epub 2017 Oct 23.
65. Preconditioning with physiological levels of ethanol protect kidney against ischemia/reperfusion injury by modulating oxidative stress. Yuan Q, etal., PLoS One. 2011;6(10):e25811. doi: 10.1371/journal.pone.0025811. Epub 2011 Oct 12.
66. Alda-1, an ALDH2 activator, protects against hepatic ischemia/reperfusion injury in rats via inhibition of oxidative stress. Zhang T, etal., Free Radic Res. 2018 Jun;52(6):629-638. doi: 10.1080/10715762.2018.1459042. Epub 2018 Apr 13.
Additional References at PubMed
PMID:1935685   PMID:7606739   PMID:7937138   PMID:7958964   PMID:8058062   PMID:8889548   PMID:9819390   PMID:10349636   PMID:10585298   PMID:10894937   PMID:10913633   PMID:10922068  
PMID:11042159   PMID:11076861   PMID:11217851   PMID:12128098   PMID:12439222   PMID:12477932   PMID:12603834   PMID:12693930   PMID:12904583   PMID:12905081   PMID:12947107   PMID:14610273  
PMID:14681479   PMID:15489334   PMID:15569633   PMID:15654606   PMID:15782199   PMID:16103363   PMID:16141072   PMID:16141073   PMID:16404140   PMID:16404141   PMID:16916647   PMID:17010132  
PMID:17010133   PMID:17452299   PMID:17980998   PMID:18157936   PMID:18550766   PMID:18596060   PMID:18614015   PMID:18704003   PMID:18799693   PMID:18971422   PMID:19101651   PMID:19215238  
PMID:19344727   PMID:19664611   PMID:19815821   PMID:19874182   PMID:19913552   PMID:20362583   PMID:20616185   PMID:20705694   PMID:21156756   PMID:21256255   PMID:21267068   PMID:21459068  
PMID:21677750   PMID:21720390   PMID:21734703   PMID:21871561   PMID:21873635   PMID:22207712   PMID:22361447   PMID:22384032   PMID:22430940   PMID:22508505   PMID:22794259   PMID:22922648  
PMID:23142317   PMID:23313283   PMID:23354068   PMID:23473983   PMID:23484127   PMID:23786406   PMID:24434637   PMID:24448831   PMID:24675227   PMID:24874076   PMID:24952961   PMID:24998256  
PMID:25084483   PMID:25086229   PMID:25155611   PMID:25163478   PMID:25237043   PMID:25263579   PMID:25467136   PMID:25713355   PMID:25807426   PMID:25910195   PMID:26315408   PMID:26374466  
PMID:26692169   PMID:26711020   PMID:26741505   PMID:27113764   PMID:27139237   PMID:27191745   PMID:27239698   PMID:27488451   PMID:27575855   PMID:27634872   PMID:27650066   PMID:27679490  
PMID:27840306   PMID:28218653   PMID:28245920   PMID:28249782   PMID:28347844   PMID:28358362   PMID:28378742   PMID:28431562   PMID:28474171   PMID:28500264   PMID:28532411   PMID:28582728  
PMID:28592637   PMID:28846100   PMID:29323295   PMID:29482068   PMID:29506687   PMID:29513653   PMID:29524404   PMID:29535452   PMID:29677191   PMID:29981795   PMID:30036570   PMID:30092566  
PMID:30196744   PMID:30315930   PMID:30371213   PMID:30375985   PMID:30474146   PMID:30550785   PMID:30733279   PMID:30853183   PMID:30946956   PMID:30973865   PMID:31071657   PMID:31074772  
PMID:31162944   PMID:31279903   PMID:31283017   PMID:31367016   PMID:31510791   PMID:31557514   PMID:31668970   PMID:31678551   PMID:31792171   PMID:31815201   PMID:31835486   PMID:32048867  
PMID:32062779   PMID:32325033   PMID:32325250   PMID:32413333   PMID:32428930   PMID:32463165   PMID:32626739   PMID:32703954   PMID:32819611   PMID:32925058   PMID:33147438   PMID:33188956  
PMID:33411685   PMID:33515676   PMID:33740503   PMID:33758417   PMID:33767380   PMID:33780653   PMID:33910156   PMID:33954430   PMID:34228649   PMID:34680107   PMID:34764958   PMID:34819667  
PMID:34944441   PMID:35012549   PMID:35188436   PMID:35315077   PMID:35318866   PMID:35354308   PMID:35770049   PMID:35815932   PMID:36114006   PMID:36229771   PMID:36256704   PMID:36528936  
PMID:36535138   PMID:36651258   PMID:36670098   PMID:36691110   PMID:36696485   PMID:36825429   PMID:36865346   PMID:36992838   PMID:37064008   PMID:37103763   PMID:37280327   PMID:37348497  
PMID:37638564   PMID:37712276   PMID:37749090   PMID:38088186   PMID:38104741   PMID:38124089   PMID:38299365  


Genomics

Comparative Map Data
Aldh2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395121,704,090 - 121,731,887 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5121,704,090 - 121,731,887 (-)EnsemblGRCm39 Ensembl
GRCm385121,566,027 - 121,593,824 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5121,566,027 - 121,593,824 (-)EnsemblGRCm38mm10GRCm38
MGSCv375122,017,696 - 122,043,833 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365121,828,319 - 121,854,203 (-)NCBIMGSCv36mm8
Celera5118,657,638 - 118,683,765 (-)NCBICelera
Cytogenetic Map5FNCBI
cM Map561.86NCBI
ALDH2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812111,766,933 - 111,817,532 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12111,766,887 - 111,817,532 (+)EnsemblGRCh38hg38GRCh38
GRCh3712112,204,737 - 112,255,336 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612110,688,729 - 110,732,167 (+)NCBINCBI36Build 36hg18NCBI36
Build 3412110,667,065 - 110,710,502NCBI
Celera12111,829,810 - 111,873,247 (+)NCBICelera
Cytogenetic Map12q24.12NCBI
HuRef12109,218,289 - 109,261,129 (+)NCBIHuRef
CHM1_112112,172,628 - 112,215,725 (+)NCBICHM1_1
T2T-CHM13v2.012111,743,846 - 111,794,443 (+)NCBIT2T-CHM13v2.0
Aldh2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81240,610,244 - 40,643,220 (+)NCBIGRCr8
mRatBN7.21234,949,549 - 34,982,527 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1234,901,219 - 34,982,521 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1236,122,427 - 36,155,172 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01236,733,638 - 36,766,383 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01235,786,091 - 35,818,829 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01240,466,418 - 40,498,813 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1240,466,495 - 40,498,752 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01242,334,057 - 42,366,049 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41236,081,778 - 36,116,445 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11235,945,165 - 35,979,833 (+)NCBI
Celera1236,614,188 - 36,647,218 (+)NCBICelera
Cytogenetic Map12q16NCBI
Aldh2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554828,352,569 - 8,384,899 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554828,352,569 - 8,383,097 (+)NCBIChiLan1.0ChiLan1.0
ALDH2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210119,836,914 - 119,879,015 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112119,833,358 - 119,875,410 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012109,343,020 - 109,385,060 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112112,734,243 - 112,776,471 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12112,734,243 - 112,776,471 (+)Ensemblpanpan1.1panPan2
ALDH2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1269,319,109 - 9,361,021 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha269,481,407 - 9,518,893 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0269,578,697 - 9,616,338 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1269,534,133 - 9,571,615 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0269,596,947 - 9,634,535 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0269,550,188 - 9,587,685 (+)NCBIUU_Cfam_GSD_1.0
Aldh2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118155,091,721 - 155,116,690 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365584,362,654 - 4,390,414 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365584,362,693 - 4,387,705 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ALDH2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1439,896,565 - 39,933,124 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11439,902,317 - 39,933,113 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21442,378,891 - 42,409,676 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ALDH2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111107,019,015 - 107,060,784 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11107,019,111 - 107,060,374 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037138,033,968 - 138,076,544 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Aldh2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474720,403,717 - 20,438,690 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474720,407,190 - 20,438,605 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Aldh2
639 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1159
Count of miRNA genes:641
Interacting mature miRNAs:804
Transcripts:ENSMUST00000031411, ENSMUST00000129753, ENSMUST00000133033, ENSMUST00000152945
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10402486Dipa1_mdrug induced psychomotor activation 1 (mouse)Not determined595465549129465722Mouse
13464244Ahl19_mage related hearing loss, early onset 19 (mouse)595465549129465722Mouse
13464243Ahl20_mage related hearing loss, early onset 20 (mouse)5107906299141906412Mouse
1300913Bwefm_mbody weight females and males day 10 (mouse)Not determined5109439348143439459Mouse
11528552Scram1_mspinal cord resistance to astrocytoma modifier 1 (mouse)5121455402151758149Mouse
1300827Cora1_mcorrelation in cytokine production 1 (mouse)Not determined5115156883149157015Mouse
1300940Actd3_mactivity-distance traveled 3 (mouse)Not determined596320385130320533Mouse
12904945Tammq2_mtibialis anterior muscle mass QTL 2 (mouse)5100665965134665965Mouse
13464251Ahl21_mage related hearing loss, early onset 21 (mouse)5109167240143167381Mouse
13506928Recrq8_mrecombination rate in male meiosis QTL 8 (mouse)574460661132528839Mouse
1357644Egrd1_mearly growth rate, direct effect 1 (mouse)Not determined595434580129434786Mouse
1301226Bbaa2_mB.burgdorferi-associated arthritis 2 (mouse)Not determined5115156883149157015Mouse
1300968Skts4_mskin tumor susceptibility 4 (mouse)Not determined589418876124238239Mouse
1300993Hycdc_mhypercapnic duty cycle (mouse)Not determined590561006124561151Mouse
1357662Lprq4_mlipoprotein QTL 4 (mouse)Not determined5114021753129632606Mouse
25314315Mlh1fc4_mMLH1 foci count 4 (mouse)574460661132528839Mouse
12904959Smmq1_msoleus muscle mass QTL 1 (mouse)5100665965134665965Mouse
14746986Manh58_mmandible shape 58 (mouse)5102446283136446283Mouse
10412239Alpq7_malcohol preference QTL 7 (mouse)Not determined5104705939138705939Mouse
10412191Bbaa24_mB.burgdorferi-associated arthritis 24 (mouse)Not determined5119945037141700466Mouse
11341716Rvfs3_mRift Valley fever susceptibility 3 (mouse)526441234138455402Mouse
4142064Tmc1m4_mTmc1 modifier 4 (mouse)Not determined554500177127001072Mouse
1301858Smdq1_msegregation of mitochondrial DNA QTL 1 (mouse)Not determined597021753131021986Mouse
10412202Bbaa26_mB.burgdorferi-associated arthritis 26 (mouse)Not determined5104583688138555455Mouse
1300659Pcd8ts1_mp-glycoprotein positive CD8 T cell subset 1 (mouse)Not determined597021753131021986Mouse
1301362Prnr1_mprion resistance 1 (mouse)Not determined589418876146787935Mouse
11532736Sluc33b_msusceptibility to lung cancer 33b (mouse)5102945037136945196Mouse
10043890Trigq4_mtriglyceride QTL 4 (mouse)Not determined5107906299141906412Mouse
11049562Lmr24f_mleishmaniasis resistance 24f (mouse)590320962124321041Mouse
1301457Cfsw2_mcystic fibrosis survival to weaning 2 (mouse)Not determined590561006124561151Mouse
27226719Tibw6_mtibia width 6, proximal, 16 week (mouse)572857343139985755Mouse
4141139Hmtb4_mhemostasis and thrombosis rebleeding time 4 (mouse)Not determined108762509126882944Mouse
1301543Hypch_mhypercholesterolemia (mouse)Not determined5109238624139118905Mouse
1301974Chab7_mcholesterol absorption 7 (mouse)Not determined595233214129233330Mouse
4141081Nidd7k_mNidd7 on KK-A (mouse)Not determined119945037149347326Mouse
1301986Bpq4_mblood pressure QTL 4 (mouse)Not determined5121555236151758149Mouse
4141519Hmtb5_mhemostasis and thrombosis bleeding time 5 (mouse)Not determined99949422126882944Mouse
4142473Chlq11_mcirculating hormone level QTL 11 (mouse)Not determined5107906299141906412Mouse
1301102Cia14_mcollagen induced arthritis 14 (mouse)Not determined5113320385138555455Mouse
1301857Bglq14_mbody growth late QTL 14 (mouse)Not determined5118948964151758149Mouse
26884395Humsd2_mhumerus midshaft diameter 2, 10 week (mouse)570057343132528839Mouse
9587780Afw16_mabdominal fat weight QTL 16 (mouse)Not determined592830166126830285Mouse
1558774Lith17_mlithogenic gene 17 (mouse)Not determined595465549129465722Mouse
10412197Bbaa25_mB.burgdorferi-associated arthritis 25 (mouse)Not determined5109167240143167381Mouse
12859290Criq2_mCitrobacter rodentium infection QTL 2 (mouse)5101332579135332579Mouse
1301624Aevm2_mautoimmune extremity vasculitis in MRL mice 2 (mouse)Not determined5101863832135864028Mouse

Markers in Region
U07235  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385121,567,880 - 121,568,002UniSTSGRCm38
MGSCv375122,017,889 - 122,018,011UniSTSGRCm37
Celera5118,657,831 - 118,657,953UniSTS
Cytogenetic Map5F-G1UniSTS
Whitehead/MRC_RH51478.8UniSTS
Aldh2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5F-G1UniSTS
cM Map5 UniSTS
ksks393  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385121,573,581 - 121,574,827UniSTSGRCm38
MGSCv375122,023,590 - 122,024,836UniSTSGRCm37
Celera5118,663,530 - 118,664,776UniSTS
Cytogenetic Map5F-G1UniSTS
Aldh2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5F-G1UniSTS
cM Map5 UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001308450 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_009656 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC155316 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK035145 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK042326 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK043506 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK078626 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK079602 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK128913 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK146286 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK150233 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK150250 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK150920 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK150986 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK151763 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK151826 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK153128 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK160060 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK163452 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK165032 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK178107 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK178856 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK183984 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK184586 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK188389 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK189526 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK195415 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK196319 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK199304 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK201448 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK202147 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK204164 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK205315 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK205536 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK206029 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK206041 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK207282 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK207960 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK209308 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK210785 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK210831 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK210893 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK211165 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK211406 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK212848 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK213635 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK214596 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK214889 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK214965 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK216794 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK219088 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK219951 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW050084 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CO039039 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S71509 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U07235 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z32545 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSMUST00000031411   ⟹   ENSMUSP00000031411
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5121,704,090 - 121,731,887 (-)Ensembl
GRCm38.p6 Ensembl5121,566,027 - 121,593,824 (-)Ensembl
RefSeq Acc Id: ENSMUST00000129753   ⟹   ENSMUSP00000142906
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5121,708,379 - 121,731,643 (-)Ensembl
GRCm38.p6 Ensembl5121,570,316 - 121,593,580 (-)Ensembl
RefSeq Acc Id: ENSMUST00000133033
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5121,709,535 - 121,713,190 (-)Ensembl
GRCm38.p6 Ensembl5121,571,472 - 121,575,127 (-)Ensembl
RefSeq Acc Id: ENSMUST00000152945   ⟹   ENSMUSP00000123545
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5121,714,520 - 121,731,645 (-)Ensembl
GRCm38.p6 Ensembl5121,576,457 - 121,593,582 (-)Ensembl
RefSeq Acc Id: ENSMUST00000196694
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5121,705,941 - 121,709,250 (-)Ensembl
GRCm38.p6 Ensembl5121,567,878 - 121,571,187 (-)Ensembl
RefSeq Acc Id: ENSMUST00000199369   ⟹   ENSMUSP00000143261
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5121,705,942 - 121,717,729 (-)Ensembl
GRCm38.p6 Ensembl5121,567,879 - 121,579,666 (-)Ensembl
RefSeq Acc Id: ENSMUST00000200541   ⟹   ENSMUSP00000143034
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5121,706,020 - 121,710,901 (-)Ensembl
GRCm38.p6 Ensembl5121,567,957 - 121,572,838 (-)Ensembl
RefSeq Acc Id: NM_001308450   ⟹   NP_001295379
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395121,708,379 - 121,731,887 (-)NCBI
GRCm385121,570,316 - 121,593,824 (-)NCBI
Sequence:
RefSeq Acc Id: NM_009656   ⟹   NP_033786
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395121,704,090 - 121,731,887 (-)NCBI
GRCm385121,566,027 - 121,593,824 (-)NCBI
MGSCv375122,017,696 - 122,043,833 (-)RGD
Celera5118,657,638 - 118,683,765 (-)RGD
cM Map5 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_033786   ⟸   NM_009656
- Peptide Label: isoform 1 precursor
- UniProtKB: P47738 (UniProtKB/Swiss-Prot),   Q544B1 (UniProtKB/TrEMBL),   Q3TVM2 (UniProtKB/TrEMBL),   Q3U6I3 (UniProtKB/TrEMBL),   Q3U9J7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001295379   ⟸   NM_001308450
- Peptide Label: isoform 2 precursor
- UniProtKB: A0A0G2JEU1 (UniProtKB/TrEMBL),   Q3TVM2 (UniProtKB/TrEMBL),   Q3U6I3 (UniProtKB/TrEMBL),   Q3U9J7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000031411   ⟸   ENSMUST00000031411
RefSeq Acc Id: ENSMUSP00000123545   ⟸   ENSMUST00000152945
RefSeq Acc Id: ENSMUSP00000143261   ⟸   ENSMUST00000199369
RefSeq Acc Id: ENSMUSP00000142906   ⟸   ENSMUST00000129753
RefSeq Acc Id: ENSMUSP00000143034   ⟸   ENSMUST00000200541
Protein Domains
Aldehyde dehydrogenase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P47738-F1-model_v2 AlphaFold P47738 1-519 view protein structure

Promoters
RGD ID:6887930
Promoter ID:EPDNEW_M7416
Type:initiation region
Name:Aldh2_1
Description:Mus musculus aldehyde dehydrogenase 2, mitochondrial , transcriptvariant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm385121,593,586 - 121,593,646EPDNEW
RGD ID:6848816
Promoter ID:MM_TRO:7779
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney,   Liver,   Lung
Transcripts:MTR000895.5.2245.7
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv365122,021,911 - 122,022,517 (-)MPROMDB
RGD ID:6837062
Promoter ID:MM_KWN:43899
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver,   Lung
Transcripts:OTTMUST00000056976
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv365122,025,161 - 122,026,017 (-)MPROMDB
RGD ID:6847877
Promoter ID:MM_ACW:39300
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney,   Liver
Transcripts:ALDH2.FSEP07-UNSPLICED
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv365122,028,461 - 122,029,517 (-)MPROMDB
RGD ID:6837061
Promoter ID:MM_KWN:43900
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000056973,   OTTMUST00000056975,   UC008ZJU.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv365122,043,481 - 122,044,217 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:99600 AgrOrtholog
Ensembl Genes ENSMUSG00000029455 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000031411 ENTREZGENE
  ENSMUST00000031411.15 UniProtKB/Swiss-Prot
  ENSMUST00000129753 ENTREZGENE
  ENSMUST00000129753.8 UniProtKB/TrEMBL
  ENSMUST00000152945.3 UniProtKB/TrEMBL
  ENSMUST00000199369.5 UniProtKB/TrEMBL
  ENSMUST00000200541.5 UniProtKB/TrEMBL
InterPro Ald_DH/histidinol_DH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ald_DH_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ald_DH_CS_CYS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ald_DH_CS_GLU UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ald_DH_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aldehyde_DH_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:11669 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:99600 ENTREZGENE
NCBI Gene 11669 ENTREZGENE
PANTHER ALDEHYDE DEHYDROGENASE, MITOCHONDRIAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ALDEHYDE DEHYDROGENASE-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Aldedh UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB ALDH2 RGD
PhenoGen Aldh2 PhenoGen
PROSITE ALDEHYDE_DEHYDR_CYS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ALDEHYDE_DEHYDR_GLU UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF53720 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JEU1 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2JF60_MOUSE UniProtKB/TrEMBL
  A0A0G2JFQ0_MOUSE UniProtKB/TrEMBL
  ALDH2_MOUSE UniProtKB/Swiss-Prot
  D3YYF3_MOUSE UniProtKB/TrEMBL
  P47738 ENTREZGENE
  Q3TVM2 ENTREZGENE, UniProtKB/TrEMBL
  Q3U6I3 ENTREZGENE, UniProtKB/TrEMBL
  Q3U9J7 ENTREZGENE, UniProtKB/TrEMBL
  Q3UJW1_MOUSE UniProtKB/TrEMBL
  Q544B1 ENTREZGENE, UniProtKB/TrEMBL