Csf1 (colony stimulating factor 1 (macrophage)) - Rat Genome Database

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Gene: Csf1 (colony stimulating factor 1 (macrophage)) Mus musculus
Symbol: Csf1
Name: colony stimulating factor 1 (macrophage)
RGD ID: 731067
Description: Enables macrophage colony-stimulating factor receptor binding activity and protein homodimerization activity. Involved in several processes, including macrophage colony-stimulating factor signaling pathway; microglial cell proliferation; and positive regulation of gene expression. Acts upstream of or within several processes, including macrophage homeostasis; mammary gland development; and positive regulation of myeloid leukocyte differentiation. Located in extracellular space. Part of CSF1-CSF1R complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and hindlimb long bone. Used to study osteopetrosis. Human ortholog(s) of this gene implicated in interstitial cystitis. Orthologous to human CSF1 (colony stimulating factor 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: BAP025; C87615; Csf; CSF-; CSF-1; Csfm; M-CS; M-CSF; macrophage colony-stimulating factor 1; MCSF; Mhdabap25; op; osteopetrosis
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm393107,648,364 - 107,668,048 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3107,648,364 - 107,667,785 (-)EnsemblGRCm39 Ensembl
GRCm383107,741,048 - 107,760,469 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3107,741,048 - 107,760,469 (-)EnsemblGRCm38mm10GRCm38
MGSCv373107,543,966 - 107,563,387 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363107,869,116 - 107,888,525 (-)NCBIMGSCv36mm8
Celera3110,073,392 - 110,092,813 (-)NCBICelera
Cytogenetic Map3F2.3NCBI
cM Map346.83NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-amphetamine  (EXP)
1,1-dichloroethene  (EXP)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
1-octadec-9-enoylglycero-3-phosphate  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-tert-butylhydroquinone  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-acetyldeoxynivalenol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4-phenylbutyric acid  (EXP)
5-azacytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
Aflatoxin B2 alpha  (ISO)
aldehydo-D-glucosamine  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
aripiprazole  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
asbestos  (ISO)
aspartame  (EXP)
atazanavir sulfate  (ISO)
benzalkonium chloride  (EXP)
benzamide  (EXP)
benzene  (EXP,ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
benzoates  (ISO)
beta-D-glucosamine  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (EXP,ISO)
butyric acid  (ISO)
C.I. Natural Red 20  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbon nanotube  (EXP)
CGP 52608  (ISO)
chenodeoxycholic acid  (ISO)
cholesterol  (ISO)
choline  (EXP)
cisplatin  (EXP)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (EXP)
crotonaldehyde  (ISO)
curcumin  (ISO)
cycloheximide  (EXP)
cyclophosphamide  (EXP)
cyclosporin A  (EXP,ISO)
deoxycholic acid  (ISO)
dexamethasone  (EXP)
dextran sulfate  (EXP)
dibenz[a,h]anthracene  (EXP)
diclofenac  (EXP)
dioxygen  (EXP,ISO)
dorsomorphin  (ISO)
elemental selenium  (ISO)
endosulfan  (ISO)
enzyme inhibitor  (EXP,ISO)
epoxiconazole  (EXP)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
fenamidone  (EXP)
fenvalerate  (ISO)
finasteride  (ISO)
flutamide  (ISO)
folic acid  (EXP,ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
genistein  (EXP)
gentamycin  (ISO)
glafenine  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
graphite  (ISO)
GW 4064  (ISO)
histamine  (EXP)
hydrogen peroxide  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (EXP,ISO)
LY294002  (EXP)
methamphetamine  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
monosodium L-glutamate  (EXP)
Muraglitazar  (ISO)
N-acetyl-L-cysteine  (EXP)
N-nitrosodimethylamine  (ISO)
nefazodone  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
niclosamide  (EXP)
nitric oxide  (EXP,ISO)
o-anisidine  (ISO)
oxaliplatin  (ISO)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
pentachlorophenol  (EXP)
perfluorodecanoic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (ISO)
perfluoroundecanoic acid  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP)
raloxifene  (ISO)
resveratrol  (EXP,ISO)
Risedronate sodium  (EXP)
rotenone  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
SB 431542  (ISO)
selenium atom  (ISO)
Shikonin  (EXP)
silicon dioxide  (EXP,ISO)
sirolimus  (EXP)
sodium arsenite  (EXP,ISO)
Soman  (ISO)
succimer  (EXP)
sulindac  (ISO)
T-2 toxin  (ISO)
tacrolimus hydrate  (EXP)
tamoxifen  (EXP)
tartrazine  (ISO)
terameprocol  (EXP)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetracycline  (EXP)
thioacetamide  (ISO)
thymidine  (ISO)
titanium dioxide  (EXP)
topotecan  (ISO)
triadimefon  (ISO)
trichloroethene  (EXP,ISO)
triclosan  (ISO)
triptonide  (EXP)
troglitazone  (ISO)
urethane  (ISO)
zinc atom  (EXP)
zinc sulfate  (EXP)
zinc(0)  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
branching involved in mammary gland duct morphogenesis  (IMP)
cell population proliferation  (ISO)
cell population proliferation  (ISO)
cellular response to parathyroid hormone stimulus  (ISO)
developmental process involved in reproduction  (IMP)
homeostasis of number of cells within a tissue  (IMP)
immune system process  (IEA)
inflammatory response  (IEA)
innate immune response  (IEA)
macrophage colony-stimulating factor signaling pathway  (IDA)
macrophage differentiation  (IMP,ISO)
macrophage homeostasis  (IMP)
mammary duct terminal end bud growth  (IMP)
mammary gland fat development  (IMP)
microglial cell proliferation  (IGI)
monocyte differentiation  (IMP)
monocyte homeostasis  (IMP)
myeloid leukocyte migration  (IGI)
negative regulation of neuron death  (ISO)
neutrophil homeostasis  (IMP)
odontogenesis  (ISO)
odontogenesis  (ISO)
ossification  (ISO)
osteoclast differentiation  (IBA,IDA,IGI,IMP,ISO)
osteoclast proliferation  (IDA)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cell-matrix adhesion  (IGI)
positive regulation of gene expression  (IDA,ISO)
positive regulation of leukocyte migration  (IGI)
positive regulation of macrophage chemotaxis  (ISO)
positive regulation of macrophage colony-stimulating factor signaling pathway  (ISO)
positive regulation of macrophage derived foam cell differentiation  (ISO)
positive regulation of macrophage differentiation  (IBA,IMP,ISO)
positive regulation of macrophage migration  (ISO)
positive regulation of macrophage proliferation  (ISO)
positive regulation of microglial cell migration  (ISO)
positive regulation of monocyte differentiation  (IMP)
positive regulation of mononuclear cell migration  (ISO)
positive regulation of mononuclear cell proliferation  (ISO)
positive regulation of multicellular organism growth  (IMP)
positive regulation of odontogenesis of dentin-containing tooth  (IMP)
positive regulation of osteoclast differentiation  (IDA,IGI,IMP,ISO)
positive regulation of protein kinase activity  (IGI)
positive regulation of protein metabolic process  (ISO)
positive regulation of Ras protein signal transduction  (IDA)
Ras protein signal transduction  (IDA)
regulation of ossification  (IMP)
response to ischemia  (ISO)
response to lipopolysaccharide  (ISO)
response to mechanical stimulus  (ISO)
response to organic cyclic compound  (ISO)
transmembrane receptor protein tyrosine kinase signaling pathway  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal auditory brainstem response  (IAGP)
abnormal auditory brainstem response waveform shape  (IAGP)
abnormal autopod morphology  (IAGP)
abnormal bone marrow cavity morphology  (IAGP)
abnormal bone marrow cell morphology/development  (IAGP)
abnormal bone marrow morphology  (IAGP)
abnormal bone remodeling  (IAGP)
abnormal bone structure  (IAGP)
abnormal branching of the mammary ductal tree  (IAGP)
abnormal circulating calcium level  (IAGP)
abnormal compact bone morphology  (IAGP)
abnormal dental follicle morphology  (IAGP)
abnormal dentin mineralization  (IAGP)
abnormal eating behavior  (IAGP)
abnormal femur morphology  (IEA)
abnormal forebrain morphology  (IAGP)
abnormal hematopoietic stem cell morphology  (IAGP)
abnormal immune system physiology  (IAGP)
abnormal Kupffer cell morphology  (IAGP)
abnormal lactation  (IAGP)
abnormal Langerhans cell morphology  (IAGP)
abnormal Langerhans cell physiology  (IAGP)
abnormal long bone hypertrophic chondrocyte zone  (IAGP)
abnormal lymph node cell ratio  (IAGP)
abnormal mammary gland alveolus morphology  (IAGP)
abnormal mammary gland development  (IAGP)
abnormal mammary gland growth during lactation  (IAGP)
abnormal mammary gland growth during pregnancy  (IAGP)
abnormal mammary gland lobule morphology  (IAGP)
abnormal masseter muscle morphology  (IEA)
abnormal mating frequency  (IAGP)
abnormal microglial cell morphology  (IAGP)
abnormal myelination  (IAGP)
abnormal myeloid leukocyte morphology  (IAGP)
abnormal neurite morphology  (IAGP)
abnormal oligodendrocyte morphology  (IAGP)
abnormal oligodendrocyte physiology  (IAGP)
abnormal osteoblast morphology  (IAGP)
abnormal osteoblast physiology  (IAGP)
abnormal osteoclast cell number  (IAGP)
abnormal osteoclast differentiation  (IAGP)
abnormal osteoclast morphology  (IAGP)
abnormal osteocyte dendritic process morphology  (IAGP)
abnormal osteocyte lacuna morphology  (IAGP)
abnormal osteocyte morphology  (IAGP)
abnormal ovarian folliculogenesis  (IAGP)
abnormal ovary morphology  (IAGP)
abnormal ovulation  (IAGP)
abnormal parietal bone morphology  (IEA)
abnormal perivascular macrophage morphology  (IAGP)
abnormal postnatal growth  (IAGP)
abnormal predentin morphology  (IAGP)
abnormal proestrus  (IAGP)
abnormal pulmonary alveolus morphology  (IAGP)
abnormal response to transplant  (IAGP)
abnormal skeleton morphology  (IAGP)
abnormal sperm number  (IAGP)
abnormal spleen red pulp morphology  (IAGP)
abnormal splenic cell ratio  (IAGP)
abnormal splenocyte physiology  (IAGP)
abnormal testis physiology  (IAGP)
abnormal thyroid parafollicular C-cell morphology  (IAGP)
abnormal tibia morphology  (IAGP)
abnormal tooth root development  (IAGP)
abnormal trabecular bone morphology  (IAGP)
abnormal uterine epithelium development  (IAGP)
abnormal vestibular system physiology  (IAGP)
abnormal visual evoked potential  (IAGP)
absent incisors  (IAGP)
absent Langerhans cell  (IAGP)
absent teeth  (IAGP)
amyloid beta deposits  (IAGP)
decreased B cell number  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased bone marrow cell number  (IAGP)
decreased bone mineralization  (IAGP)
decreased bone resorption  (IAGP)
decreased circulating alkaline phosphatase level  (IAGP)
decreased circulating phosphate level  (IAGP)
decreased circulating testosterone level  (IAGP)
decreased compact bone thickness  (IAGP)
decreased corpora lutea number  (IAGP)
decreased fertilization frequency  (IAGP)
decreased hippocampus pyramidal cell number  (IAGP)
decreased length of long bones  (IAGP)
decreased leukocyte cell number  (IAGP)
decreased litter size  (IAGP)
decreased lymphocyte cell number  (IAGP)
decreased macrophage cell number  (IAGP)
decreased mature ovarian follicle number  (IAGP)
decreased monocyte cell number  (IAGP)
decreased oligodendrocyte number  (IAGP)
decreased oligodendrocyte progenitor number  (IAGP)
decreased osteoclast cell number  (IAGP)
decreased ovulation rate  (IAGP)
decreased physiological sensitivity to xenobiotic  (IAGP)
decreased spleen weight  (IAGP)
decreased susceptibility to atherosclerosis  (IAGP)
decreased tertiary ovarian follicle number  (IAGP)
decreased trabecular bone thickness  (IAGP)
demyelination  (IAGP)
domed cranium  (IAGP)
endometrium hypoplasia  (IAGP)
extramedullary hematopoiesis  (IAGP)
failure of tooth eruption  (IAGP)
fragile skeleton  (IAGP)
hindlimb paralysis  (IAGP)
impaired embryo implantation  (IAGP)
impaired granulosa cell differentiation  (IAGP)
impaired macrophage chemotaxis  (IAGP)
impaired osteoblast differentiation  (IAGP)
increased bone mass  (IAGP)
increased bone trabecula number  (IAGP)
increased circulating cholesterol level  (IAGP)
increased circulating tumor necrosis factor level  (IAGP)
increased granulocyte number  (IAGP)
increased hemoglobin content  (IAGP)
increased long bone epiphyseal plate size  (IAGP)
increased neutrophil cell number  (IAGP)
increased osteocyte apoptosis  (IAGP)
increased T cell number  (IAGP)
increased testis weight  (IAGP)
increased trabecular bone mass  (IAGP)
increased trabecular bone volume  (IAGP)
increased width of hypertrophic chondrocyte zone  (IAGP)
interstitial pneumonia  (IAGP)
liver inflammation  (IAGP)
lung inflammation  (IAGP)
myometrium hypoplasia  (IAGP)
necrospermia  (IAGP)
oligozoospermia  (IAGP)
osteopetrosis  (IAGP)
osteoporosis  (IAGP)
osteosclerosis  (IAGP)
polycythemia  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature death  (IAGP)
prolonged estrous cycle  (IAGP)
pulmonary alveolar proteinosis  (IAGP)
reduced female fertility  (IAGP)
reduced fertility  (IAGP)
reduced male fertility  (IAGP)
reduced male mating frequency  (IAGP)
round snout  (IAGP)
short limbs  (IAGP)
short tail  (IAGP)
slow postnatal weight gain  (IAGP)
small spleen  (IAGP)
thymus cortex hypoplasia  (IAGP)
thymus medulla atrophy  (IAGP)
tremors  (IAGP)
weight loss  (IAGP)

References - curated
# Reference Title Reference Citation
1. Increased expression of macrophage colony-stimulating factor and its receptor in patients with endometriosis. Budrys NM, etal., Fertil Steril. 2012 May;97(5):1129-35.e1. doi: 10.1016/j.fertnstert.2012.02.007. Epub 2012 Feb 24.
2. Mapping the cytokine profile of painful bladder syndrome/interstitial cystitis in human bladder and urine specimens. Corcoran AT, etal., World J Urol. 2013 Feb;31(1):241-6. doi: 10.1007/s00345-012-0852-y. Epub 2012 Mar 24.
3. Inflammation Profiling of Critically Ill Coronavirus Disease 2019 Patients. Fraser DD, etal., Crit Care Explor. 2020 Jun 22;2(6):e0144. doi: 10.1097/CCE.0000000000000144. eCollection 2020 Jun.
4. Serum level of macrophage colony-stimulating factor and atherosclerosis in hemodialysis patients. Haraguchi K, etal., Nephron Clin Pract. 2006;102(1):c14-20. Epub 2005 Sep 13.
5. Local macrophage proliferation correlates with increased renal M-CSF expression in human glomerulonephritis. Isbel NM, etal., Nephrol Dial Transplant. 2001 Aug;16(8):1638-47.
6. Preventive and therapeutic effects of imatinib in Wistar-Kyoto rats with anti-glomerular basement membrane glomerulonephritis. Iyoda M, etal., Kidney Int. 2009 May;75(10):1060-70. doi: 10.1038/ki.2009.43. Epub 2009 Feb 25.
7. Distinct in vivo roles of colony-stimulating factor-1 isoforms in renal inflammation. Jang MH, etal., J Immunol. 2006 Sep 15;177(6):4055-63.
8. Antiangiogenic drugs synergize with a membrane macrophage colony-stimulating factor-based tumor vaccine to therapeutically treat rats with an established malignant intracranial glioma. Jeffes EW, etal., J Immunol. 2005 Mar 1;174(5):2533-43.
9. Interleukin-10 deficiency aggravates kidney inflammation and fibrosis in the unilateral ureteral obstruction mouse model. Jin Y, etal., Lab Invest. 2013 Jul;93(7):801-11. doi: 10.1038/labinvest.2013.64. Epub 2013 Apr 29.
10. Immunophenotypical characterization of macrophages in rat bleomycin-induced scleroderma. Juniantito V, etal., Vet Pathol. 2013 Jan;50(1):76-85. doi: 10.1177/0300985812450718. Epub 2012 Jun 13.
11. Overexpression of the colony-stimulating factor (CSF-1) and/or its receptor c-fms in mammary glands of transgenic mice results in hyperplasia and tumor formation. Kirma N, etal., Cancer Res. 2004 Jun 15;64(12):4162-70.
12. Macrophage colony-stimulating factor expression and macrophage accumulation in renal allograft rejection. Le Meur Y, etal., Transplantation. 2002 Apr 27;73(8):1318-24.
13. Negative role of colony-stimulating factor-1 in macrophage, T cell, and B cell mediated autoimmune disease in MRL-Fas(lpr) mice. Lenda DM, etal., J Immunol. 2004 Oct 1;173(7):4744-54.
14. Fcγ Receptor I-Coupled Signaling in Peripheral Nociceptors Mediates Joint Pain in a Rat Model of Rheumatoid Arthritis. Liu F, etal., Arthritis Rheumatol. 2020 Oct;72(10):1668-1678. doi: 10.1002/art.41386. Epub 2020 Sep 6.
15. Expression of macrophage colony-stimulating factor (M-CSF) and its receptor in streptozotocin-induced diabetic rats. Liu W, etal., Curr Eye Res. 2009 Feb;34(2):123-33. doi: 10.1080/02713680802650369.
16. Autocrine CSF-1 and CSF-1 receptor coexpression promotes renal cell carcinoma growth. Menke J, etal., Cancer Res. 2012 Jan 1;72(1):187-200. doi: 10.1158/0008-5472.CAN-11-1232. Epub 2011 Nov 3.
17. Distinct roles of CSF-1 isoforms in lupus nephritis. Menke J, etal., J Am Soc Nephrol. 2011 Oct;22(10):1821-33. doi: 10.1681/ASN.2011010038. Epub 2011 Sep 1.
18. Sunlight triggers cutaneous lupus through a CSF-1-dependent mechanism in MRL-Fas(lpr) mice. Menke J, etal., J Immunol. 2008 Nov 15;181(10):7367-79.
19. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
20. MGDs mouse GO annotations MGD data from the GO Consortium
22. Up-regulation of macrophage colony-stimulating factor (M-CSF) and migration inhibitory factor (MIF) expression and monocyte recruitment during lipid-induced glomerular injury in the exogenous hypercholesterolaemic (ExHC) rat. Miyazaki K, etal., Clin Exp Immunol. 1997 May;108(2):318-23.
23. Colony-stimulating factor-1 antibody reverses chemoresistance in human MCF-7 breast cancer xenografts. Paulus P, etal., Cancer Res. 2006 Apr 15;66(8):4349-56.
24. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
25. Heterozygous osteopetrotic (op) mutation reduces atherosclerosis in LDL receptor- deficient mice. Rajavashisth T, etal., J Clin Invest 1998 Jun 15;101(12):2702-10.
26. Mouse MP Annotation Import Pipeline RGD automated import pipeline
27. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
28. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
29. The prognostic impact of M-CSF, CSF-1 receptor, CD68 and CD3 in prostatic carcinoma. Richardsen E, etal., Histopathology. 2008 May 28;.
30. Nitric oxide, enhanced by macrophage-colony stimulating factor, mediates renal damage in reflux nephropathy. Rolle U, etal., Kidney Int. 2002 Aug;62(2):507-13.
31. [Mediators of amyloidogenesis and cytokines in dialysis-related amyloidosis]. Rysava R, etal., Cas Lek Cesk. 2002 Apr 26;141(8):244-7.
32. Expansion of CD4+CD16+ blood monocytes in patients with chronic renal failure undergoing dialysis: possible involvement of macrophage colony-stimulating factor. Saionji K and Ohsaka A, Acta Haematol. 2001;105(1):21-6.
33. Renal epithelial cell-derived monocyte colony stimulating factor as a local informant of renal injury and means of monocyte activation. Singh KA, etal., Transpl Int. 2009 Jul;22(7):730-7. doi: 10.1111/j.1432-2277.2009.00840.x. Epub 2009 Jan 29.
34. Circulating colony stimulating factor-1 and breast cancer risk. Tamimi RM, etal., Cancer Res. 2008 Jan 1;68(1):18-21.
35. Urinary levels of RANTES and M-CSF are predictors of lupus nephritis flare. Tian S, etal., Inflamm Res. 2007 Jul;56(7):304-10.
36. The effect of macrophage colony-stimulating factor (M-CSF) on the progression of lipid-induced nephrotoxicity in diabetic nephropathy. Utsunomiya K, etal., J Diabetes Complications. 1995 Oct-Dec;9(4):292-5.
37. The osteopetrotic mutation toothless (tl) is a loss-of-function frameshift mutation in the rat Csf1 gene: Evidence of a crucial role for CSF-1 in osteoclastogenesis and endochondral ossification. Van Wesenbeeck L, etal., Proc Natl Acad Sci U S A 2002 Oct 29;99(22):14303-8.
38. Macrophage-colony stimulating factor as an inducer of microglial proliferation in axotomized rat facial nucleus. Yamamoto S, etal., J Neurochem. 2010 Nov;115(4):1057-67. doi: 10.1111/j.1471-4159.2010.06996.x. Epub 2010 Oct 12.
39. Plasma IP-10 and MCP-3 levels are highly associated with disease severity and predict the progression of COVID-19. Yang Y, etal., J Allergy Clin Immunol. 2020 Apr 29. pii: S0091-6749(20)30576-5. doi: 10.1016/j.jaci.2020.04.027.
40. CSF-1 signaling mediates recovery from acute kidney injury. Zhang MZ, etal., J Clin Invest. 2012 Dec 3;122(12):4519-32. doi: 10.1172/JCI60363. Epub 2012 Nov 12.
Additional References at PubMed
PMID:489953   PMID:1262696   PMID:1374350   PMID:1378025   PMID:1426147   PMID:1431208   PMID:1505635   PMID:1552482   PMID:1581229   PMID:1718333   PMID:1733926   PMID:1827757  
PMID:1834496   PMID:1840281   PMID:1840317   PMID:1874443   PMID:1887865   PMID:1912583   PMID:2146111   PMID:2188141   PMID:2191302   PMID:2408759   PMID:2457916   PMID:2554332  
PMID:2565740   PMID:2676841   PMID:2990035   PMID:3002522   PMID:3261346   PMID:3493488   PMID:3494232   PMID:3547079   PMID:3925458   PMID:4796241   PMID:5372803   PMID:7130905  
PMID:7507352   PMID:7514458   PMID:7542490   PMID:7543541   PMID:7554968   PMID:7572282   PMID:7579387   PMID:7616613   PMID:7621075   PMID:7622488   PMID:7627801   PMID:7667279  
PMID:7696959   PMID:7704903   PMID:7735981   PMID:7742081   PMID:7760840   PMID:7780134   PMID:7795257   PMID:7850025   PMID:7884321   PMID:7894173   PMID:7937762   PMID:7962166  
PMID:8003009   PMID:8018921   PMID:8034307   PMID:8040836   PMID:8045348   PMID:8050349   PMID:8137761   PMID:8148154   PMID:8148672   PMID:8149328   PMID:8150037   PMID:8158905  
PMID:8164195   PMID:8182336   PMID:8193367   PMID:8203474   PMID:8207122   PMID:8314887   PMID:8357831   PMID:8358920   PMID:8379385   PMID:8399834   PMID:8418205   PMID:8426088  
PMID:8427048   PMID:8461535   PMID:8479820   PMID:8510378   PMID:8543387   PMID:8554922   PMID:8595766   PMID:8603573   PMID:8630510   PMID:8647916   PMID:8691066   PMID:8754800  
PMID:8781564   PMID:8787741   PMID:8788202   PMID:8793557   PMID:8828834   PMID:8874489   PMID:8889548   PMID:8896402   PMID:8929623   PMID:8981357   PMID:8981359   PMID:8981362  
PMID:8981364   PMID:8981365   PMID:8981368   PMID:9002639   PMID:9039846   PMID:9116300   PMID:9137093   PMID:9145288   PMID:9160730   PMID:9167635   PMID:9168824   PMID:9176397  
PMID:9180904   PMID:9215625   PMID:9261328   PMID:9281358   PMID:9328346   PMID:9364807   PMID:9372970   PMID:9383699   PMID:9421432   PMID:9438423   PMID:9461606   PMID:9535794  
PMID:9543701   PMID:9555870   PMID:9573014   PMID:9593582   PMID:9648288   PMID:9729335   PMID:9811459   PMID:9819371   PMID:9828134   PMID:9837769   PMID:9852586   PMID:9892622  
PMID:9893162   PMID:9990422   PMID:10022968   PMID:10027413   PMID:10067173   PMID:10075153   PMID:10349636   PMID:10369734   PMID:10378148   PMID:10393854   PMID:10416154   PMID:10416155  
PMID:10441375   PMID:10548345   PMID:10575640   PMID:10626897   PMID:10725249   PMID:10731091   PMID:10802718   PMID:10804170   PMID:10805971   PMID:10828017   PMID:10914502   PMID:10919279  
PMID:10922068   PMID:10935450   PMID:11042159   PMID:11076861   PMID:11179357   PMID:11217851   PMID:11257139   PMID:11266447   PMID:11312257   PMID:11376872   PMID:11381616   PMID:11408267  
PMID:11418465   PMID:11438923   PMID:11498728   PMID:11518254   PMID:11673514   PMID:11675359   PMID:11679445   PMID:11684011   PMID:11756160   PMID:11891983   PMID:11897698   PMID:11906524  
PMID:11923298   PMID:11956177   PMID:12004339   PMID:12054176   PMID:12074549   PMID:12074592   PMID:12112025   PMID:12117983   PMID:12193691   PMID:12201247   PMID:12202638   PMID:12223521  
PMID:12466851   PMID:12477932   PMID:12517946   PMID:12614284   PMID:12626584   PMID:12694543   PMID:12705859   PMID:12714570   PMID:12865350   PMID:12874264   PMID:12929928   PMID:14516793  
PMID:14525772   PMID:14613812   PMID:14749363   PMID:14969389   PMID:15027489   PMID:15137062   PMID:15178709   PMID:15213096   PMID:15221008   PMID:15259023   PMID:15271901   PMID:15489334  
PMID:15585886   PMID:15615857   PMID:15657444   PMID:15744782   PMID:15894167   PMID:15899577   PMID:16007221   PMID:16034075   PMID:16100037   PMID:16125055   PMID:16141072   PMID:16141073  
PMID:16157517   PMID:16172157   PMID:16172397   PMID:16210339   PMID:16237150   PMID:16250018   PMID:16267818   PMID:16294221   PMID:16444257   PMID:16514418   PMID:16600665   PMID:16684892  
PMID:16707491   PMID:16823860   PMID:16877523   PMID:16897342   PMID:16920972   PMID:16962581   PMID:17029292   PMID:17053831   PMID:17114237   PMID:17114485   PMID:17114491   PMID:17126805  
PMID:17142347   PMID:17218256   PMID:17243865   PMID:17339609   PMID:17363585   PMID:17403683   PMID:17404308   PMID:17420256   PMID:17431224   PMID:17438263   PMID:17442941   PMID:17475873  
PMID:17485799   PMID:17652450   PMID:17673544   PMID:17712116   PMID:17971207   PMID:17982061   PMID:18006080   PMID:18056041   PMID:18093340   PMID:18097035   PMID:18198176   PMID:18202111  
PMID:18322228   PMID:18328744   PMID:18337452   PMID:18354213   PMID:18422785   PMID:18436538   PMID:18488036   PMID:18509509   PMID:18511911   PMID:18566389   PMID:18632616   PMID:18682602  
PMID:18710945   PMID:18724005   PMID:18768880   PMID:18852237   PMID:18990370   PMID:19017797   PMID:19033389   PMID:19109221   PMID:19109434   PMID:19120972   PMID:19130475   PMID:19141689  
PMID:19270176   PMID:19303020   PMID:19376223   PMID:19396881   PMID:19398755   PMID:19427849   PMID:19587381   PMID:19587445   PMID:19632180   PMID:19668347   PMID:19711348   PMID:19758725  
PMID:19808890   PMID:19819976   PMID:19819979   PMID:19846874   PMID:19906951   PMID:19926892   PMID:20001844   PMID:20031174   PMID:20037154   PMID:20142327   PMID:20189586   PMID:20194110  
PMID:20230796   PMID:20388773   PMID:20404134   PMID:20489731   PMID:20504948   PMID:20572009   PMID:20625428   PMID:20647543   PMID:21048959   PMID:21203444   PMID:21239712   PMID:21257824  
PMID:21356377   PMID:21389217   PMID:21411758   PMID:21614016   PMID:21677750   PMID:21703406   PMID:21791433   PMID:21822305   PMID:21825019   PMID:21873635   PMID:21876121   PMID:21909098  
PMID:21922246   PMID:21958845   PMID:22006978   PMID:22046273   PMID:22078798   PMID:22105655   PMID:22110092   PMID:22153499   PMID:22159280   PMID:22294205   PMID:22385964   PMID:22451653  
PMID:22457635   PMID:22467656   PMID:22479646   PMID:22527485   PMID:22542597   PMID:22547697   PMID:22565823   PMID:22579672   PMID:22670054   PMID:22682244   PMID:22902366   PMID:23117661  
PMID:23201131   PMID:23260168   PMID:23296467   PMID:23372702   PMID:23392676   PMID:23426679   PMID:23451116   PMID:23520016   PMID:23525041   PMID:23648053   PMID:23725022   PMID:23988615  
PMID:24006456   PMID:24019961   PMID:24101381   PMID:24197832   PMID:24238961   PMID:24394418   PMID:24400092   PMID:24468794   PMID:24633240   PMID:24652541   PMID:24743235   PMID:24859337  
PMID:24866235   PMID:24906644   PMID:24948010   PMID:24952961   PMID:25036630   PMID:25042473   PMID:25131634   PMID:25157821   PMID:25192716   PMID:25282358   PMID:25331958   PMID:25373902  
PMID:25420919   PMID:25423036   PMID:25561180   PMID:25628221   PMID:25788575   PMID:25897174   PMID:26019271   PMID:26091486   PMID:26094741   PMID:26229149   PMID:26253821   PMID:26336156  
PMID:26529564   PMID:26634935   PMID:26642091   PMID:26642357   PMID:26865613   PMID:27009605   PMID:27013192   PMID:27183631   PMID:27581357   PMID:27634833   PMID:27723723   PMID:27941021  
PMID:28052488   PMID:28159742   PMID:28329690   PMID:28348107   PMID:28426964   PMID:28431249   PMID:28606987   PMID:28627369   PMID:28634350   PMID:28655719   PMID:28697890   PMID:28780306  
PMID:28978329   PMID:29180574   PMID:29398113   PMID:29416028   PMID:29422647   PMID:29666241   PMID:29757143   PMID:29861285   PMID:29891514   PMID:29968565   PMID:30054206   PMID:30096434  
PMID:30120124   PMID:30142160   PMID:30144320   PMID:30258231   PMID:30290143   PMID:30352428   PMID:30504915   PMID:30538245   PMID:30664659   PMID:30687013   PMID:30760925   PMID:30767584  
PMID:30936475   PMID:31053503   PMID:31204558   PMID:31251389   PMID:31350310   PMID:31356686   PMID:31375314   PMID:31421080   PMID:31515941   PMID:31541001   PMID:31552020   PMID:31616414  
PMID:31732166   PMID:31824413   PMID:32005697   PMID:32097462   PMID:32188632   PMID:32493987   PMID:32562599   PMID:32565279   PMID:32641386   PMID:32756440   PMID:32777109   PMID:32873797  
PMID:32895539   PMID:32959911   PMID:32999463   PMID:33086870   PMID:33097708   PMID:33142674   PMID:33253203   PMID:33568812   PMID:33652607   PMID:33662369   PMID:34056970   PMID:34183017  
PMID:34231109   PMID:34281564   PMID:34652270   PMID:34742624   PMID:35075211   PMID:35315360   PMID:35353625   PMID:35508166   PMID:35737933   PMID:35930670   PMID:35970974   PMID:36692312  


Comparative Map Data
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm393107,648,364 - 107,668,048 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3107,648,364 - 107,667,785 (-)EnsemblGRCm39 Ensembl
GRCm383107,741,048 - 107,760,469 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3107,741,048 - 107,760,469 (-)EnsemblGRCm38mm10GRCm38
MGSCv373107,543,966 - 107,563,387 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363107,869,116 - 107,888,525 (-)NCBIMGSCv36mm8
Celera3110,073,392 - 110,092,813 (-)NCBICelera
Cytogenetic Map3F2.3NCBI
cM Map346.83NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381109,910,506 - 109,930,992 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1109,910,242 - 109,930,992 (+)EnsemblGRCh38hg38GRCh38
GRCh371110,453,471 - 110,473,614 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361110,254,980 - 110,273,878 (+)NCBINCBI36Build 36hg18NCBI36
Build 341110,165,498 - 110,184,397NCBI
Celera1108,699,836 - 108,719,046 (+)NCBICelera
Cytogenetic Map1p13.3NCBI
HuRef1108,322,980 - 108,343,084 (+)NCBIHuRef
CHM1_11110,568,036 - 110,588,399 (+)NCBICHM1_1
T2T-CHM13v2.01109,920,986 - 109,941,109 (+)NCBIT2T-CHM13v2.0
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.22195,377,215 - 195,396,608 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2195,377,215 - 195,411,704 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2203,018,890 - 203,037,935 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02200,901,047 - 200,920,075 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02195,717,984 - 195,737,022 (-)NCBIRnor_WKY
Rnor_6.02210,522,370 - 210,550,546 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2210,522,375 - 210,550,560 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02229,989,430 - 230,017,945 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42203,292,765 - 203,307,968 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12203,255,518 - 203,270,701 (-)NCBI
Celera2188,024,644 - 188,043,645 (-)NCBICelera
Cytogenetic Map2q34NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495543513,404,508 - 13,424,247 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543513,404,236 - 13,423,059 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.11127,764,916 - 127,864,188 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1127,764,916 - 127,781,943 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01112,555,755 - 112,575,894 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1642,028,454 - 42,047,028 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl642,034,149 - 42,049,371 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha644,804,295 - 44,823,439 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0642,360,013 - 42,379,162 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl642,360,330 - 42,379,600 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1642,092,785 - 42,111,910 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0642,050,361 - 42,070,486 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0642,485,555 - 42,505,704 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440505818,720,989 - 18,742,009 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367041,378,103 - 1,393,542 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049367041,372,137 - 1,393,355 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl4110,178,475 - 110,197,900 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14110,178,466 - 110,198,232 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24120,592,959 - 120,605,764 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.12023,615,107 - 23,635,399 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603834,824,127 - 34,844,440 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046247725,663,070 - 5,707,753 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247725,663,374 - 5,705,965 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID

Predicted Target Of
Summary Value
Count of predictions:2446
Count of miRNA genes:696
Interacting mature miRNAs:871
Transcripts:ENSMUST00000014743, ENSMUST00000118593, ENSMUST00000120243, ENSMUST00000120654, ENSMUST00000153114, ENSMUST00000155557, ENSMUST00000156820
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884436Zlq3_mzygomatic length QTL 3, 10 week (mouse)33265060142405761Mouse
26884427Cvht4_mcranial vault height 4, 10 week (mouse)316054164109707316Mouse
13207570Tcq12_mtotal cholesterol QTL 12 (mouse)316504164130163649Mouse
26884422Cvht7_mcranial vault height 7, 16 week (mouse)328954149118893649Mouse
1302056Orgwq4_morgan weight QTL 4 (mouse)Not determined330067588147304689Mouse
1301705Sles3_msystemic lupus erythmatosus suppressor 3 (mouse)Not determined337174862143353183Mouse
13208566Bmiq5_mbody mass index QTL 5 (mouse)340954435115793649Mouse
26884382Bzwq1_mbi-zygomatic width QTL 1, 5 week (mouse)352207421137205761Mouse
25314313Syncl1_msynaptonemal complex length 1 (mouse)367907333128393649Mouse
1300595Tmevd2_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 2 (mouse)Not determined375463302109463549Mouse
1301392Eae3_msusceptibility to experimental allergic encephalomyelitis 3 (mouse)Not determined379548730113548837Mouse
1301947Pcfm3_mperiosteal circumference and femur length 3 (mouse)Not determined381084652115084797Mouse
1301904Iba2_minduction of brown adipocytes 2 (mouse)Not determined382147043116147184Mouse
11041900Lmr11a_mleishmaniasis resistance 11a (mouse)383463991117464137Mouse
11039510Ltpr3d_mLeishmania tropica response 3d (mouse)383463991117464137Mouse
11039511Ltpr3c_mLeishmania tropica response 3c (mouse)383463991117464137Mouse
11039507Ltpr3g_mLeishmania tropica response 3g (mouse)383463991117464137Mouse
11039508Ltpr3f_mLeishmania tropica response 3f (mouse)383463991117464137Mouse
11039509Ltpr3e_mLeishmania tropica response 3e (mouse)383463991117464137Mouse
11039512Ltpr3b_mLeishmania tropica response 3b (mouse)383463991117464137Mouse
1301272Cfsw1_mcystic fibrosis survival to weaning 1 (mouse)Not determined383882912117883044Mouse
4142099Cq3_mcholesterol QTL 3 (mouse)Not determined384888918118889067Mouse
14746984Manh54_mmandible shape 54 (mouse)385289152119289152Mouse
1357583Sle18_msystematic lupus erythematosus susceptibility 18 (mouse)Not determined387208904125316236Mouse
12738440Twq3_mtestis weight QTL 3 (mouse)387228015121228015Mouse
4142178Ctrq2_mC. trachomatis resistance QTL 2 (mouse)Not determined389139967137453008Mouse
10766455Sle22_msystematic lupus erythematosus susceptibility 22 (mouse)390376936124377072Mouse
14747001Mancz4_mmandible centroid size 4 (mouse)390378017124378017Mouse
1302052Etohcta4_methanol conditioned taste aversion 4 (mouse)Not determined391000105125008748Mouse
1301349Pgia26_mproteoglycan induced arthritis 26 (mouse)Not determined392251533126251650Mouse
27226732Tibmd3_mtibia midshaft diameter 3, 10 week (mouse)396607316147805636Mouse
10043955Wt10q4_mbody weight, 10 weeks, QTL 4 (mouse)Not determined398624041132624197Mouse
11533920Mvb3_mmodifier of vibrator 3 (mouse)398635284132635383Mouse
12792984Modn1_mmodifier of Dstn neovascularization 1 (mouse)398635284132635383Mouse
1302114Tbs1_mtuberculosis severity 1 (mouse)Not determined398924105132924250Mouse
1300752Ap6q_malcohol preference 6 QTL (mouse)Not determined3100372912147045722Mouse
26884419Bzwq6_mbi-zygomatic width QTL 6, 10 week (mouse)3100607316137205761Mouse
27226733Tibmd6_mtibia midshaft diameter 6, 16 week (mouse)3101307316149805637Mouse
1301805Mors2_mmodifier of obesity related sterility 2 (mouse)Not determined3103482659137482783Mouse
1357599msrvh1_mmodifier of susceptibility to renal vascular hypertrophy/hyperplasia 1 (mouse)Not determined3107376936115624197Mouse
8655599Cia5c_mcollagen induced arthritis QTL 5c (mouse)Not determined3107376936125316237Mouse
1302093Orgwq5_morgan weight QTL 5 (mouse)Not determined3107376936147304689Mouse

Markers in Region
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm383107,741,769 - 107,741,977UniSTSGRCm38
MGSCv373107,544,687 - 107,544,895UniSTSGRCm37
Celera3110,074,113 - 110,074,321UniSTS
Cytogenetic Map3F3UniSTS
cM Map351.0UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm383107,742,656 - 107,742,821UniSTSGRCm38
MGSCv373107,545,574 - 107,545,739UniSTSGRCm37
Celera3110,075,000 - 110,075,165UniSTS
Cytogenetic Map3F3UniSTS
cM Map351.0UniSTS
Whitehead_YAC3 UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm383107,745,595 - 107,745,764UniSTSGRCm38
MGSCv373107,548,513 - 107,548,682UniSTSGRCm37
Celera3110,077,939 - 110,078,108UniSTS
Cytogenetic Map3F3UniSTS
cM Map351.0UniSTS
Whitehead_YAC17 UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm383107,759,435 - 107,759,527UniSTSGRCm38
MGSCv373107,562,353 - 107,562,445UniSTSGRCm37
Celera3110,091,779 - 110,091,871UniSTS
Cytogenetic Map3F3UniSTS
cM Map352.5UniSTS
Whitehead Genetic339.3UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm383107,760,371 - 107,760,614UniSTSGRCm38
MGSCv373107,563,289 - 107,563,532UniSTSGRCm37
Celera3110,092,715 - 110,092,958UniSTS
Cytogenetic Map3F3UniSTS
cM Map352.5UniSTS
cM Map3 UniSTS
Whitehead Genetic339.3UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm383107,759,522 - 107,759,678UniSTSGRCm38
MGSCv373107,562,440 - 107,562,596UniSTSGRCm37
Celera3110,091,866 - 110,092,022UniSTS
Cytogenetic Map3F3UniSTS
cM Map352.5UniSTS
cM Map3 UniSTS
Whitehead Genetic339.3UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm383107,759,348 - 107,759,457UniSTSGRCm38
MGSCv373107,562,266 - 107,562,375UniSTSGRCm37
Celera3110,091,692 - 110,091,801UniSTS
Cytogenetic Map3F3UniSTS
cM Map352.5UniSTS
cM Map3 UniSTS
Whitehead Genetic339.3UniSTS
Whitehead_YAC3 UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm383107,742,086 - 107,742,296UniSTSGRCm38
MGSCv373107,545,004 - 107,545,214UniSTSGRCm37
Celera3110,074,430 - 110,074,640UniSTS
Cytogenetic Map3F3UniSTS
cM Map351.0UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm383107,748,699 - 107,749,060UniSTSGRCm38
MGSCv373107,551,617 - 107,551,978UniSTSGRCm37
Celera3110,081,043 - 110,081,404UniSTS
Cytogenetic Map3F3UniSTS
cM Map351.0UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm383107,760,026 - 107,760,217UniSTSGRCm38
MGSCv373107,562,944 - 107,563,135UniSTSGRCm37
Celera3110,092,370 - 110,092,561UniSTS
Cytogenetic Map3F3UniSTS
cM Map351.0UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm383107,742,677 - 107,742,826UniSTSGRCm38
MGSCv373107,545,595 - 107,545,744UniSTSGRCm37
Celera3110,075,021 - 110,075,170UniSTS
Cytogenetic Map3F3UniSTS
cM Map351.0UniSTS



Nucleotide Sequences
RefSeq Transcripts NM_001113529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001113530 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_007778 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036162878 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036162879 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036162880 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC140786 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI844210 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK136808 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK138489 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK154261 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK154872 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK160995 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK166370 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK170154 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC025593 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC066187 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC066200 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC066205 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA328312 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466607 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M15692 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M21149 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M21952 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M81316 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S78392 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X05010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000014743   ⟹   ENSMUSP00000014743
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3107,648,364 - 107,667,785 (-)Ensembl
GRCm38.p6 Ensembl3107,741,048 - 107,760,469 (-)Ensembl
RefSeq Acc Id: ENSMUST00000118593   ⟹   ENSMUSP00000113136
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3107,648,364 - 107,667,552 (-)Ensembl
GRCm38.p6 Ensembl3107,741,048 - 107,760,236 (-)Ensembl
RefSeq Acc Id: ENSMUST00000120243   ⟹   ENSMUSP00000113617
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3107,652,911 - 107,667,558 (-)Ensembl
GRCm38.p6 Ensembl3107,745,595 - 107,760,242 (-)Ensembl
RefSeq Acc Id: ENSMUST00000120654   ⟹   ENSMUSP00000112832
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3107,650,330 - 107,658,295 (-)Ensembl
GRCm38.p6 Ensembl3107,743,014 - 107,750,979 (-)Ensembl
RefSeq Acc Id: ENSMUST00000153114   ⟹   ENSMUSP00000115480
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3107,657,696 - 107,667,537 (-)Ensembl
GRCm38.p6 Ensembl3107,750,380 - 107,760,221 (-)Ensembl
RefSeq Acc Id: ENSMUST00000155557
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3107,655,049 - 107,667,558 (-)Ensembl
GRCm38.p6 Ensembl3107,747,733 - 107,760,242 (-)Ensembl
RefSeq Acc Id: ENSMUST00000156820   ⟹   ENSMUSP00000119553
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3107,655,858 - 107,658,057 (-)Ensembl
GRCm38.p6 Ensembl3107,748,542 - 107,750,741 (-)Ensembl
RefSeq Acc Id: NM_001113529   ⟹   NP_001107001
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm393107,648,364 - 107,667,785 (-)NCBI
GRCm383107,741,048 - 107,760,469 (-)ENTREZGENE
MGSCv373107,543,966 - 107,563,387 (-)RGD
Celera3110,073,392 - 110,092,813 (-)RGD
RefSeq Acc Id: NM_001113530   ⟹   NP_001107002
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm393107,652,911 - 107,667,785 (-)NCBI
GRCm383107,745,595 - 107,760,469 (-)NCBI
MGSCv373107,543,966 - 107,563,387 (-)RGD
Celera3110,073,392 - 110,092,813 (-)RGD
RefSeq Acc Id: NM_007778   ⟹   NP_031804
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm393107,648,364 - 107,667,785 (-)NCBI
GRCm383107,741,048 - 107,760,469 (-)ENTREZGENE
MGSCv373107,543,966 - 107,563,387 (-)RGD
Celera3110,073,392 - 110,092,813 (-)RGD
RefSeq Acc Id: XM_036162878   ⟹   XP_036018771
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm393107,648,371 - 107,668,048 (-)NCBI
RefSeq Acc Id: XM_036162879   ⟹   XP_036018772
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm393107,652,909 - 107,668,048 (-)NCBI
RefSeq Acc Id: XM_036162880   ⟹   XP_036018773
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm393107,648,371 - 107,668,048 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001107001 (Get FASTA)   NCBI Sequence Viewer  
  NP_001107002 (Get FASTA)   NCBI Sequence Viewer  
  NP_031804 (Get FASTA)   NCBI Sequence Viewer  
  XP_036018771 (Get FASTA)   NCBI Sequence Viewer  
  XP_036018772 (Get FASTA)   NCBI Sequence Viewer  
  XP_036018773 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA19866 (Get FASTA)   NCBI Sequence Viewer  
  AAA37480 (Get FASTA)   NCBI Sequence Viewer  
  AAA37481 (Get FASTA)   NCBI Sequence Viewer  
  AAA37482 (Get FASTA)   NCBI Sequence Viewer  
  AAB34634 (Get FASTA)   NCBI Sequence Viewer  
  AAH25593 (Get FASTA)   NCBI Sequence Viewer  
  AAH66187 (Get FASTA)   NCBI Sequence Viewer  
  AAH66200 (Get FASTA)   NCBI Sequence Viewer  
  AAH66205 (Get FASTA)   NCBI Sequence Viewer  
  BAE23681 (Get FASTA)   NCBI Sequence Viewer  
  BAE32472 (Get FASTA)   NCBI Sequence Viewer  
  BAE32893 (Get FASTA)   NCBI Sequence Viewer  
  BAE36140 (Get FASTA)   NCBI Sequence Viewer  
  BAE38736 (Get FASTA)   NCBI Sequence Viewer  
  BAE41601 (Get FASTA)   NCBI Sequence Viewer  
  CAA28660 (Get FASTA)   NCBI Sequence Viewer  
  EDL01915 (Get FASTA)   NCBI Sequence Viewer  
  EDL01916 (Get FASTA)   NCBI Sequence Viewer  
  EDL01917 (Get FASTA)   NCBI Sequence Viewer  
  EDL01918 (Get FASTA)   NCBI Sequence Viewer  
  EDL01919 (Get FASTA)   NCBI Sequence Viewer  
  P07141 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_031804   ⟸   NM_007778
- Peptide Label: isoform 1 precursor
- UniProtKB: Q8R3C8 (UniProtKB/Swiss-Prot),   P07141 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001107001   ⟸   NM_001113529
- Peptide Label: isoform 2 precursor
- UniProtKB: P07141 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001107002   ⟸   NM_001113530
- Peptide Label: isoform 1 precursor
- UniProtKB: Q8R3C8 (UniProtKB/Swiss-Prot),   P07141 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000113136   ⟸   ENSMUST00000118593
RefSeq Acc Id: ENSMUSP00000014743   ⟸   ENSMUST00000014743
RefSeq Acc Id: ENSMUSP00000112832   ⟸   ENSMUST00000120654
RefSeq Acc Id: ENSMUSP00000113617   ⟸   ENSMUST00000120243
RefSeq Acc Id: ENSMUSP00000115480   ⟸   ENSMUST00000153114
RefSeq Acc Id: ENSMUSP00000119553   ⟸   ENSMUST00000156820
RefSeq Acc Id: XP_036018773   ⟸   XM_036162880
- Peptide Label: isoform X2
RefSeq Acc Id: XP_036018771   ⟸   XM_036162878
- Peptide Label: isoform X1
RefSeq Acc Id: XP_036018772   ⟸   XM_036162879
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P07141-F1-model_v2 AlphaFold P07141 1-552 view protein structure

RGD ID:6833608
Promoter ID:MM_KWN:35726
SO ACC ID:SO:0000170
Tissues & Cell Lines:3T3L1_Day0,   BoneMarrow_2Hour,   Brain,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000120654,   OTTMUST00000065745
Mouse AssemblyChrPosition (strand)Source
MGSCv363107,553,641 - 107,554,812 (-)MPROMDB
RGD ID:6833607
Promoter ID:MM_KWN:35727
SO ACC ID:SO:0000170
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:NM_001113529,   NM_001113530,   NM_007778,   OTTMUST00000065743,   UC008QXN.1
Mouse AssemblyChrPosition (strand)Source
MGSCv363107,562,924 - 107,563,424 (-)MPROMDB
RGD ID:6850144
Promoter ID:EP37007
Type:single initiation site
Description:Colony stimulating factor-1, CSF1 or CSFM gene.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Notes:homology_group=Homology group 213; Mammalian colony stimulating factor 1
Experiment Methods:Primer extension with homologous sequence ladder; Sequencing of a full-length cDNA; experiments performed with; closely related gene
Regulation:various tissues; (induced by or strongly expressed in) proliferation
Mouse AssemblyChrPosition (strand)Source
MGSCv373107,563,163 - 107,563,223EPD
MGSCv363107,563,163 - 107,563,223EPD
RGD ID:6882030
Promoter ID:EPDNEW_M4463
Type:initiation region
Description:Mus musculus colony stimulating factor 1 , transcript variant3, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M4464  
Experiment Methods:Single-end sequencing.
Mouse AssemblyChrPosition (strand)Source
GRCm383107,760,242 - 107,760,302EPDNEW
RGD ID:6882026
Promoter ID:EPDNEW_M4464
Type:multiple initiation site
Description:Mus musculus colony stimulating factor 1 , transcript variant3, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M4463  
Experiment Methods:Single-end sequencing.
Mouse AssemblyChrPosition (strand)Source
GRCm383107,760,475 - 107,760,535EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1339753 AgrOrtholog
Ensembl Genes ENSMUSG00000014599 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000014743 ENTREZGENE
  ENSMUSP00000014743.4 UniProtKB/Swiss-Prot
  ENSMUSP00000112832.2 UniProtKB/TrEMBL
  ENSMUSP00000113136.2 UniProtKB/Swiss-Prot
  ENSMUSP00000113617.2 UniProtKB/Swiss-Prot
  ENSMUSP00000115480.2 UniProtKB/TrEMBL
  ENSMUSP00000119553.2 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000014743 ENTREZGENE
  ENSMUST00000014743.10 UniProtKB/Swiss-Prot
  ENSMUST00000118593.8 UniProtKB/Swiss-Prot
  ENSMUST00000120243.8 UniProtKB/Swiss-Prot
  ENSMUST00000120654.8 UniProtKB/TrEMBL
  ENSMUST00000153114.2 UniProtKB/TrEMBL
  ENSMUST00000156820.2 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1250.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro 4_helix_cytokine-like_core UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MCSF-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:12977 UniProtKB/Swiss-Prot
  PTHR10058 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam CSF-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Csf1 PhenoGen
PIRSF MCSF-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47266 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt CSF1_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q3U395 UniProtKB/Swiss-Prot
  Q8R3C8 UniProtKB/Swiss-Prot