Il17b (interleukin 17B) - Rat Genome Database

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Gene: Il17b (interleukin 17B) Mus musculus
Analyze
Symbol: Il17b
Name: interleukin 17B
RGD ID: 1553356
MGI Page MGI
Description: Enables cytokine activity. Acts upstream of or within positive regulation of cytokine production involved in inflammatory response. Predicted to be located in extracellular space. Is expressed in several structures, including central nervous system; dorsal root ganglion; limb; limb bud; and trunk. Orthologous to human IL17B (interleukin 17B).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 1110006O16Rik; 1700006N07Rik; cytokine CX1; cytokine-like protein ZCYTO7; gene for cytokine-like protein; IL-17B; interleukin-17B; neuronal interleukin-17-related factor; Zcyto; Zcyto7
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391861,821,006 - 61,825,609 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1861,817,958 - 61,825,609 (+)EnsemblGRCm39 Ensembl
GRCm381861,687,935 - 61,692,538 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1861,684,887 - 61,692,538 (+)EnsemblGRCm38mm10GRCm38
MGSCv371861,847,589 - 61,852,191 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361861,813,304 - 61,817,906 (+)NCBIMGSCv36mm8
Celera1862,970,900 - 62,975,972 (+)NCBICelera
Cytogenetic Map18E1NCBI
cM Map1834.67NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4. Mouse MP Annotation Import Pipeline RGD automated import pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:10749887   PMID:11042159   PMID:11076861   PMID:11738356   PMID:12477932   PMID:14610273   PMID:15489334   PMID:15596145   PMID:16081819   PMID:16141072   PMID:16141073  
PMID:16602821   PMID:16698929   PMID:17982105   PMID:20562862   PMID:21677750   PMID:23851503   PMID:25888259   PMID:30824326   PMID:36046722   PMID:36814913  


Genomics

Comparative Map Data
Il17b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391861,821,006 - 61,825,609 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1861,817,958 - 61,825,609 (+)EnsemblGRCm39 Ensembl
GRCm381861,687,935 - 61,692,538 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1861,684,887 - 61,692,538 (+)EnsemblGRCm38mm10GRCm38
MGSCv371861,847,589 - 61,852,191 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361861,813,304 - 61,817,906 (+)NCBIMGSCv36mm8
Celera1862,970,900 - 62,975,972 (+)NCBICelera
Cytogenetic Map18E1NCBI
cM Map1834.67NCBI
IL17B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385149,374,267 - 149,404,202 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5149,371,324 - 149,404,202 (-)EnsemblGRCh38hg38GRCh38
GRCh375148,753,830 - 148,783,765 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365148,734,023 - 148,739,031 (-)NCBINCBI36Build 36hg18NCBI36
Build 345148,734,024 - 148,739,031NCBI
Celera5144,835,805 - 144,840,813 (-)NCBICelera
Cytogenetic Map5q32NCBI
HuRef5143,900,155 - 143,905,163 (-)NCBIHuRef
CHM1_15148,186,259 - 148,191,267 (-)NCBICHM1_1
T2T-CHM13v2.05149,909,114 - 149,939,047 (-)NCBIT2T-CHM13v2.0
Il17b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81857,411,532 - 57,415,903 (+)NCBIGRCr8
mRatBN7.21855,141,194 - 55,145,565 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1855,141,194 - 55,145,565 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1857,234,781 - 57,239,079 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01857,949,431 - 57,953,743 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01855,765,055 - 55,769,426 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01857,011,575 - 57,016,009 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1857,011,575 - 57,016,009 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01856,240,488 - 56,244,922 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41857,665,293 - 57,669,668 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11857,739,647 - 57,741,775 (+)NCBI
Celera1853,290,941 - 53,295,289 (+)NCBICelera
Cytogenetic Map18q12.1NCBI
Il17b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554155,041,375 - 5,047,449 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554155,037,270 - 5,047,405 (+)NCBIChiLan1.0ChiLan1.0
IL17B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24144,604,299 - 144,607,629 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15142,743,848 - 142,763,536 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05144,800,664 - 144,842,788 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15150,811,055 - 150,840,085 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5150,811,055 - 150,815,930 (-)Ensemblpanpan1.1panPan2
IL17B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1459,578,568 - 59,584,069 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl459,543,080 - 59,583,968 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha459,341,309 - 59,352,992 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0460,058,822 - 60,070,520 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl460,060,397 - 60,066,539 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1459,845,455 - 59,857,144 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0459,960,072 - 59,971,763 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0460,490,476 - 60,502,167 (+)NCBIUU_Cfam_GSD_1.0
Il17b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213143,908,738 - 143,915,822 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365045,482,972 - 5,489,899 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365045,485,009 - 5,489,788 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL17B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2150,541,180 - 150,545,367 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12150,513,611 - 150,583,640 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22157,279,046 - 157,349,566 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IL17B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12351,992,877 - 52,001,280 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2351,993,258 - 51,998,043 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603425,748,904 - 25,753,870 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Il17b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247748,732,471 - 8,739,331 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247748,733,264 - 8,763,150 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Il17b
136 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:155
Count of miRNA genes:146
Interacting mature miRNAs:152
Transcripts:ENSMUST00000025471
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357603Mom3_mmodifier of Min 3 (mouse)Not determined181403002367098962Mouse
25823173Hrsq12_mhost response to SARS QTL 12, hemorrhage (mouse)182489588178339555Mouse
1301400Lmr13_mleishmaniasis resistance 13 (mouse)Not determined182810938062109518Mouse
4141857Mhysq5_mmale hybrid sterility QTL 5 (mouse)Not determined2813060462130739Mouse
1302163Bmd16_mbone mineral density 16 (mouse)Not determined182966791463668060Mouse
12880412V125Dq12_mvitamin D active form serum level QTL 12 (mouse)183023306764233067Mouse
1300685Scc5_mcolon tumor susceptibility 5 (mouse)Not determined183198848065988629Mouse
1357690Vtbt19_mvertebral trabecular bone trait 19 (mouse)Not determined183309104367091221Mouse
1301771Pcyts6_mplasmacytoma susceptibility 6 (mouse)Not determined183565863269658851Mouse
4142366Chlq10_mcirculating hormone level QTL 10 (mouse)Not determined183629102270291180Mouse
15039381Ltgq8_mliver triglyceride QTL 8 (mouse)183820656972206569Mouse
15039383Mvlq5_mmicrovesicular liver lesion QTL 5 (mouse)183820656972206569Mouse
15039384Liviq1_mliver inflammation QTL 1 (mouse)183820656972206569Mouse
15039386Mvlq4_mmacrovesicular liver lesion QTL 4 (mouse)183820656972206569Mouse
12050070Nabq2_mnasal bone morphology QTL 2 (mouse)183910367773103793Mouse
1357639Obsty4_mobesity 4 (mouse)Not determined183961991484638778Mouse
1301902Hrtfm4_mheart failure modifier 4 (mouse)Not determined184331112077311343Mouse
1301215Thcr_mT helper cell response (mouse)Not determined184513060468778777Mouse
12904745Carcdq2_mcardiac collagen deposition QTL 2 (mouse)184642328780423287Mouse
11039493Ltpr8d_mLeishmania tropica response 8d (mouse)184687490380875042Mouse
11039494Ltpr8b_mLeishmania tropica response 8b (mouse)184687490380875042Mouse
27226720Tibw5_mtibia width 5, proximal, 10 week (mouse)185043306762633071Mouse
1357630Tgq1_mtriglyceride QTL 1 (mouse)Not determined185105215685052311Mouse
11252137Modvl5_mmodifier of vacuolated lens 5 (mouse)185105215685052311Mouse
10412244Par5_mpulmonary adenoma resistance 5 (mouse)Not determined185166830085668468Mouse
1302099Hdlq30_mHDL QTL 30 (mouse)Not determined185166830085668468Mouse
1301853Heal9_mwound healing/regeneration 9 (mouse)Not determined185280527686805416Mouse
1302050Radpf4_mradiation pulmonary fibrosis 4 (mouse)Not determined185296615668778777Mouse
4142443Pgis1_mproteoglycan induced spondylitis 1 (mouse)Not determined185329102276914293Mouse
1301500Szs4_mseizure susceptibility 4 (mouse)Not determined185497587385514143Mouse
12880410V125Dq13_mvitamin D active form serum level QTL 13 (mouse)185643307190433071Mouse
12880430Fgf23lq4_mFGF23 serum level QTL 4 (mouse)185643307190433071Mouse
10412183Sstapa2_mSuseptibility to Staphylococus aureus infection 2 (mouse)Not determined185679463066952485Mouse
12880428V125Dq14_mvitamin D active form serum level QTL 14 (mouse)185743307190720763Mouse
1301353Lbw6_mlupus NZB x NZW 6 (mouse)Not determined185756233890720763Mouse
4141132Eae18_mexperimental allergic encephalomyelitis susceptibility 18 (mouse)Not determined5759055982604728Mouse
4140971Mbmq1_mmale body mass QTL 1 (mouse)Not determined5799028190720763Mouse
12910791Pwgrq8_mpre-weaning growth rate QTL 8 (mouse)185802139969349142Mouse
11049564Lmr29_mleishmaniasis resistance 29 (mouse)185918009290720763Mouse
11039495Ltpr8c_mLeishmania tropica response 8c (mouse)185918009290720763Mouse
11039492Ltpr8a_mLeishmania tropica response 8a (mouse)185918009290720763Mouse
1301103Pgia11_mproteoglycan induced arthritis 11 (mouse)Not determined185991418490720763Mouse
1302109Sluc28_msusceptibility to lung cancer 28 (mouse)Not determined185993532190720763Mouse
38455998Cdtm1_mCD62L+ CD8 TM cells 1 (mouse)186013307280043215Mouse
4142239Idd21.2_minsulin dependent diabetes susceptibility 21.2 (mouse)Not determined186127244874562414Mouse
1558803W3q16_mweight 3 weeks QTL 16 (mouse)Not determined186127244881491831Mouse
1558782Orgwq9_morgan weight QTL 9 (mouse)Not determined186127244882604728Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000025471   ⟹   ENSMUSP00000025471
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1861,821,006 - 61,825,609 (+)Ensembl
GRCm38.p6 Ensembl1861,687,935 - 61,692,538 (+)Ensembl
RefSeq Acc Id: ENSMUST00000235713   ⟹   ENSMUSP00000157496
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1861,820,986 - 61,825,607 (+)Ensembl
GRCm38.p6 Ensembl1861,687,915 - 61,692,536 (+)Ensembl
RefSeq Acc Id: ENSMUST00000237575
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1861,817,958 - 61,825,609 (+)Ensembl
GRCm38.p6 Ensembl1861,684,887 - 61,692,538 (+)Ensembl
RefSeq Acc Id: NM_019508   ⟹   NP_062381
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391861,821,006 - 61,825,608 (+)NCBI
GRCm381861,687,935 - 61,692,537 (+)NCBI
MGSCv371861,847,589 - 61,852,191 (+)RGD
Celera1862,970,900 - 62,975,972 (+)RGD
cM Map18 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006526106   ⟹   XP_006526169
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391861,822,298 - 61,825,609 (+)NCBI
GRCm381861,689,086 - 61,692,538 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006526108   ⟹   XP_006526171
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391861,822,681 - 61,825,609 (+)NCBI
GRCm381861,689,609 - 61,692,538 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030250543   ⟹   XP_030106403
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391861,821,560 - 61,825,609 (+)NCBI
GRCm381861,688,488 - 61,692,538 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_062381   ⟸   NM_019508
- Peptide Label: precursor
- UniProtKB: Q99MY3 (UniProtKB/Swiss-Prot),   Q9CTI4 (UniProtKB/Swiss-Prot),   Q9QXT6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006526169   ⟸   XM_006526106
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006526171   ⟸   XM_006526108
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_030106403   ⟸   XM_030250543
- Peptide Label: isoform X2
RefSeq Acc Id: ENSMUSP00000157496   ⟸   ENSMUST00000235713
RefSeq Acc Id: ENSMUSP00000025471   ⟸   ENSMUST00000025471

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9QXT6-F1-model_v2 AlphaFold Q9QXT6 1-180 view protein structure

Promoters
RGD ID:13677960
Promoter ID:EPDNEW_M23129
Type:multiple initiation site
Name:Il17b_1
Description:Mus musculus interleukin 17B , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381861,687,915 - 61,687,975EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1928397 AgrOrtholog
Ensembl Genes ENSMUSG00000024578 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000025471 ENTREZGENE
  ENSMUST00000025471.4 UniProtKB/Swiss-Prot
  ENSMUST00000235713.2 UniProtKB/TrEMBL
Gene3D-CATH 2.10.90.10 UniProtKB/Swiss-Prot
InterPro Cystine-knot_cytokine UniProtKB/Swiss-Prot
  IL-17_chr UniProtKB/Swiss-Prot
  IL-17_fam UniProtKB/Swiss-Prot
KEGG Report mmu:56069 UniProtKB/Swiss-Prot
MGD MGI:1928397 ENTREZGENE
NCBI Gene 56069 ENTREZGENE
Pfam IL17 UniProtKB/Swiss-Prot
PhenoGen Il17b PhenoGen
PRINTS INTRLEUKIN17 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF57501 UniProtKB/Swiss-Prot
UniProt A0A494B960_MOUSE UniProtKB/TrEMBL
  IL17B_MOUSE UniProtKB/Swiss-Prot
  Q99MY3 ENTREZGENE
  Q9CTI4 ENTREZGENE
  Q9QXT6 ENTREZGENE
UniProt Secondary Q99MY3 UniProtKB/Swiss-Prot
  Q9CTI4 UniProtKB/Swiss-Prot